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Gene: Aqp6 (aquaporin 6) Chinchilla lanigera

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Symbol:

Aqp6

Name:

aquaporin 6

RGD ID:

8823246

Description:

ENCODES a protein that exhibits ammonium channel activity (ortholog); carbon dioxide transmembrane transporter activity (ortholog); monoatomic anion channel activity (ortholog); INVOLVED IN nitrate transmembrane transport (ortholog); odontogenesis (ortholog); renal water transport (ortholog); PARTICIPATES IN water transport pathway; FOUND IN cytoplasmic vesicle membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

aquaporin 6, kidney specific; aquaporin-6

RGD Orthologs

Alliance Orthologs

More Info

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More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	AQP6 (aquaporin 6)	NCBI	Ortholog
Mus musculus (house mouse):	Aqp6 (aquaporin 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Aqp6 (aquaporin 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	AQP6 (aquaporin 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	AQP6 (aquaporin 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Aqp6 (aquaporin 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	AQP6 (aquaporin 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	AQP6 (aquaporin 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Aqp6 (aquaporin 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955547	567,152 - 571,895 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955547	567,152 - 570,880 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

nitrate transmembrane transport (ISO)

odontogenesis (ISO)

renal water transport (ISO)

Cellular Component

cytoplasmic vesicle membrane (ISO)

Molecular Function

ammonium channel activity (ISO)

carbon dioxide transmembrane transporter activity (ISO)

monoatomic anion channel activity (ISO)

nitrate transmembrane transporter activity (ISO)

pH-gated chloride channel activity (ISO)

protein binding (ISO)

water channel activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

water transport pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Aqp6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955547	567,152 - 571,895 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955547	567,152 - 570,880 (+)	NCBI	ChiLan1.0	ChiLan1.0

AQP6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	49,972,947 - 49,977,139 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	49,967,194 - 49,977,139 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	50,366,730 - 50,370,922 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	48,652,887 - 48,657,189 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	48,652,891 - 48,657,189	NCBI
Celera	12	49,162,741 - 49,167,043 (+)	NCBI		Celera
Cytogenetic Map	12	q13.12	NCBI
HuRef	12	47,398,122 - 47,402,424 (+)	NCBI		HuRef
CHM1_1	12	50,332,778 - 50,337,080 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	49,935,958 - 49,940,150 (+)	NCBI		T2T-CHM13v2.0

Aqp6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	99,495,891 - 99,503,359 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	99,499,281 - 99,503,358 (+)	Ensembl		GRCm39 Ensembl
GRCm38	15	99,598,468 - 99,605,478 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	99,601,400 - 99,605,477 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	99,431,831 - 99,435,908 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	99,429,434 - 99,433,511 (+)	NCBI		MGSCv36	mm8
Celera	15	101,756,793 - 101,760,851 (+)	NCBI		Celera
Cytogenetic Map	15	F1	NCBI
cM Map	15	56.13	NCBI

Aqp6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	132,611,069 - 132,614,004 (+)	NCBI		GRCr8
mRatBN7.2	7	130,732,216 - 130,735,149 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	130,633,579 - 130,735,194 (+)	Ensembl		mRatBN7.2 Ensembl
mRatBN7.2 Ensembl	7	130,633,579 - 130,735,194 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	132,535,805 - 132,538,735 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	134,761,384 - 134,764,315 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	134,673,911 - 134,676,841 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	141,258,585 - 141,261,518 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	141,258,584 - 141,261,735 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	115,763,288 - 115,766,221 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	138,347,266 - 138,350,199 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	138,423,702 - 138,426,636 (+)	NCBI
Celera	7	127,213,574 - 127,216,507 (+)	NCBI		Celera
Cytogenetic Map	7	q36	NCBI

AQP6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	44,172,566 - 44,216,164 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	44,169,328 - 44,212,932 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	38,739,047 - 38,782,659 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	39,672,067 - 39,676,636 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	39,672,067 - 39,676,636 (-)	Ensembl	panpan1.1		panPan2

AQP6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	4,727,732 - 4,731,828 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	4,727,725 - 4,731,316 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	41,527,817 - 41,531,698 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	4,775,594 - 4,779,476 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	4,776,786 - 4,789,859 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	4,740,579 - 4,744,460 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	4,730,402 - 4,734,285 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	41,922,470 - 41,926,347 (+)	NCBI		UU_Cfam_GSD_1.0

Aqp6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	65,511,431 - 65,514,075 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936512	7,650,724 - 7,653,274 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936512	7,650,755 - 7,653,399 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AQP6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	15,887,966 - 15,890,805 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	15,888,080 - 15,892,113 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	16,068,162 - 16,071,435 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AQP6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	46,199,907 - 46,207,010 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666037	199,914,619 - 199,919,218 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Aqp6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624816	2,316,668 - 2,319,650 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624816	2,314,660 - 2,319,649 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005411858	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01072164	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDK01181608	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000001369 ⟹ ENSCLAP00000001327

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955547	567,152 - 571,895 (+)	Ensembl

RefSeq Acc Id:

XM_005411858 ⟹ XP_005411915

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955547	567,152 - 570,880 (+)	NCBI

Sequence:

show sequence

TGCACCACCACACCTAGGAAGGCATGGTCTTTGACAAAATGCCTTGATGTAATGCTGGAAGGGT
TAGGGCCAGCATAGCCACAGAAATGGTTAGGCTACCCGACTTAGCAAATAGGAATTTGGAGGGC
GCTGAGAGGGAAGTGAGCAGAGGGAGGGGTCGAGAGGGGGTGCAAGGGAAGGAAGAGGGGGAGA
AGGGCTGGCGGGAGTTCCTGAGGAGGACAGTAGCGGTACCTGGTGCCAGGTATAGCGTCCGGCA
CAGGGTGAGCAGCTCCACCGGCCCCTCCGCCCCCTCCCACGATCGCGGCCTTCGTAAAGCTGAC
ATTCACAGTTTTAGGTGGAAATGCAAGCGGGGGGCTTAATTTCATAGTTTATGGGGTACAGGAC
AGGCTCGGCCTATTTGGAGGCAGAGCTTGGAGACGGGTCAGGAGAGCTGGAGCCCTCGAAGCAG
GCCTTGGGCTCGTGAGTCTGAGGGATCTTGTCCTGTCTGCCCTGTGCCAGCAGCCCTCGGGCGA
AACCGCTGTGAGCTGCAGGAGTCAGGCCGCTCAGTCAGTCTTGGTTGTGGCATGGAAAACCTCC
TGGGAGGTTCTAGCTCAGCTCTCAAGGACGCTGCCTTATCTGCCCTCCACATCAGGTGAGCTCA
GGGGGAAGCAGGCACGTGAGCACCAGCCCTCCCAGGGTGCCCTCTGCCCACCCCCACGTGCATA
ACCCACCAGCAGGCGAGTGTCGTCCAGTGTGGCCAGCTCCTTCCTCGGCAGCAGCGCAGTAGAA
GAGCTGCAGGTGGGGTTGGTGAGGCCTCCACTCTTGGAGGCCAGAGTTAGGCAGAGACAAGAGA
CCAGGGCGGACAGGCGGAGGCCGCTCAAGGAAAGAAGGGGACAGCCAAGGCACCAGGCACGAGG
ACATGGAGCCGGGGCCGTGGAGCGGGGCCAACACGCTGCTGTGCCGGGTTTGGACGGCAGTCAG
CAAGGCACTGTTTGCTGAGTTCCTGGCCACGGGGCTGTACGTGTTCTTCGGCGTGGGCTCCGTC
CTGCGCTGGCCCTCGGCACTTCCCTCTGTGCTGCAGGTCGCCATCACCTTCAACCTGGCCACGG
CCACGGCGGTGCAGGTCACCTGGAAGACCAGCGGGGCCCACGCCAACCCCGCGGTGACGCTGGC
CTTCCTCGTAGCCTCCCACATCTCCCTGCCCCGGGCCGTGGCCTACATAGCTGCCCAGCTGGCA
GGGGCCACTGTGGGGGCTGCTCTGCTCTACGGGGTCACCCCAGGAGACGTCCGAGGGACCCTCG
GGATCAACGTGGTCCAGAACAGCACCTCGACTGGCCAGGCAGTGGCAGTGGAGCTGGTTCTGAC
CCTGCAGCTGGTGCTCTGTGTCTTTGCCTCCACGGACAGCCGTCATACACTGGGTTCCCCGGCC
GCCATGATTGGGACCTCCGTGGCGCTGGGCCACCTCATTGGGATCTACTTCACTGGCTGCTCCA
TGAATCCAGCCCGCTCCTTCGGTCCTGCAGTCATCATTGGCAAGTTCACAGTGCACTGGATCTT
CTGGGTAGGCCCCCTGACAGGGGCTGTCCTGGCTTCGCTGATCTACAACTTTATCCTGTTCCCT
GACACCAAGACTCTGGCCCAGCGACTGGCCATCCTCATGGGCACCACTGAGGTGGAGAAAGTCA
CAGAGGTGGAGGTGGAGCCTGAGAAGAAAGACTCCCAGTCCAGTTCGGGGGATACAGAAGTGAG
TGTGTGAGCCGGCATAGCCCGTGCAGGCAGGAGCCCTGAGGGTGGGCATCGGCCTGCAGGACTG
GACTCCTGGCTTTTCCGGTGAGGGGCCTGGGAGAGGGGACCGGGAGGCTCGGTTTCTTGTTCTA
ACAGTGTGGGCTGGGTTGGGAGGGCGCCAGTCCCTATCCCTGGCATTACATTTCTTTCCTCTTT
TTAAAAATGATAATGGGGATGGAATCTAGAGCCTCACACTAGGCAAGTACATCACCACTGAGCT
ACATCTAACTTCTTTTTTTATTCTGAGATAAAGTACTGCCAAGTTGTACAGGCTGGCCTCAAGC
TCACCACCCTTCTGCCTCAGCCTTCTGAGTAGTGGGGTTATAGGCATACCACATGTGCCTGTCT
TCTACAATTATAGGTAAAATAAATCTTACAGCAAGTC

hide sequence

Protein Sequences


Protein RefSeqs	XP_005411915	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000001327
	ENSCLAP00000001327.1

RefSeq Acc Id:

XP_005411915 ⟸ XM_005411858

- UniProtKB:

A0A8C2UI93 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEPGPWSGANTLLCRVWTAVSKALFAEFLATGLYVFFGVGSVLRWPSALPSVLQVAITFNLATA
TAVQVTWKTSGAHANPAVTLAFLVASHISLPRAVAYIAAQLAGATVGAALLYGVTPGDVRGTLG
INVVQNSTSTGQAVAVELVLTLQLVLCVFASTDSRHTLGSPAAMIGTSVALGHLIGIYFTGCSM
NPARSFGPAVIIGKFTVHWIFWVGPLTGAVLASLIYNFILFPDTKTLAQRLAILMGTTEVEKVT
EVEVEPEKKDSQSSSGDTEVSV

hide sequence

Ensembl Acc Id:

ENSCLAP00000001327 ⟸ ENSCLAT00000001369

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000001011	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000001369	ENTREZGENE
	ENSCLAT00000001369.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1080.10	UniProtKB/TrEMBL
InterPro	Aquaporin-like	UniProtKB/TrEMBL
	Aquaporin_6	UniProtKB/TrEMBL
	Aquaporin_transptr	UniProtKB/TrEMBL
	MIP	UniProtKB/TrEMBL
	MIP_CS	UniProtKB/TrEMBL
NCBI Gene	Aqp6	ENTREZGENE
PANTHER	PTHR19139	UniProtKB/TrEMBL
	PTHR19139:SF113	UniProtKB/TrEMBL
Pfam	MIP	UniProtKB/TrEMBL
PRINTS	AQUAPORIN6	UniProtKB/TrEMBL
	MINTRINSICP	UniProtKB/TrEMBL
PROSITE	MIP	UniProtKB/TrEMBL
Superfamily-SCOP	SSF81338	UniProtKB/TrEMBL
UniProt	A0A8C2UI93	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-16	Aqp6	aquaporin 6		aquaporin 6, kidney specific	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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