Advanced Search (OLGA)

Gene: Ppib (peptidylprolyl isomerase B) Chinchilla lanigera

Analyze

Symbol:

Ppib

Name:

peptidylprolyl isomerase B

RGD ID:

8806811

Description:

ENCODES a protein that exhibits peptidyl-prolyl cis-trans isomerase activity (ortholog); RNA polymerase binding (ortholog); INVOLVED IN bone development (ortholog); chaperone-mediated protein folding (ortholog); neutrophil chemotaxis (ortholog); PARTICIPATES IN codeine and morphine pharmacodynamics pathway; codeine and morphine pharmacokinetics pathway; etoposide pharmacodynamics pathway; ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); genetic disease (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum chaperone complex (ortholog); nucleoplasm (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

peptidyl-prolyl cis-trans isomerase B; peptidylprolyl isomerase B (cyclophilin B)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955450	11,241,279 - 11,249,056 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955450	11,241,279 - 11,246,628 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bloom syndrome (ISO)

colorectal cancer (ISO)

genetic disease (ISO)

human immunodeficiency virus infectious disease (ISO)

nemaline myopathy 6 (ISO)

osteogenesis imperfecta (ISO)

osteogenesis imperfecta type 9 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

bone development (ISO)

chaperone-mediated protein folding (ISO)

neutrophil chemotaxis (ISO)

positive regulation by host of viral genome replication (ISO)

positive regulation by host of viral process (ISO)

positive regulation of multicellular organism growth (ISO)

protein stabilization (ISO)

regulation of post-translational protein modification (ISO)

Cellular Component

endoplasmic reticulum (ISO)

endoplasmic reticulum chaperone complex (ISO)

nucleoplasm (ISO)

perinuclear region of cytoplasm (ISO)

smooth endoplasmic reticulum (ISO)

Molecular Function

peptidyl-prolyl cis-trans isomerase activity (ISO)

protein binding (ISO)

RNA polymerase binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

codeine and morphine pharmacodynamics pathway (ISO)

codeine and morphine pharmacokinetics pathway (ISO)

etoposide pharmacodynamics pathway (ISO)

etoposide pharmacokinetics pathway (ISO)

ibuprofen pharmacodynamics pathway (ISO)

ibuprofen pharmacokinetics pathway (ISO)

irinotecan pharmacodynamics pathway (ISO)

irinotecan pharmacokinetics pathway (ISO)

paracetamol pharmacokinetics pathway (ISO)

phenytoin pharmacodynamics pathway (ISO)

retinol metabolic pathway (ISO)

sorafenib pharmacokinetics pathway (ISO)

syndecan signaling pathway (ISO)

vitamin A deficiency pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Ppib
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955450	11,241,279 - 11,249,056 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955450	11,241,279 - 11,246,628 (+)	NCBI	ChiLan1.0	ChiLan1.0

PPIB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	64,155,817 - 64,163,022 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	64,155,740 - 64,163,134 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	64,448,016 - 64,455,221 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	62,235,067 - 62,242,407 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	62,235,067 - 62,242,407	NCBI
Celera	15	41,326,958 - 41,334,299 (-)	NCBI		Celera
Cytogenetic Map	15	q22.31	NCBI
HuRef	15	41,272,716 - 41,280,027 (-)	NCBI		HuRef
CHM1_1	15	64,567,543 - 64,574,883 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	15	61,962,993 - 61,970,198 (-)	NCBI		T2T-CHM13v2.0

Ppib
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	65,967,451 - 65,973,911 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	65,967,504 - 65,973,905 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	66,060,169 - 66,066,629 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	66,060,222 - 66,066,623 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	65,907,976 - 65,914,436 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	65,858,175 - 65,864,635 (+)	NCBI		MGSCv36	mm8
Celera	9	63,295,684 - 63,302,172 (+)	NCBI		Celera
Cytogenetic Map	9	C	NCBI
cM Map	9	35.69	NCBI

Ppib
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	75,498,966 - 75,504,823 (+)	NCBI		GRCr8
mRatBN7.2	8	66,603,877 - 66,609,734 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	66,603,861 - 66,630,428 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	72,116,410 - 72,122,281 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	70,389,471 - 70,395,342 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	68,259,312 - 68,265,165 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	71,719,681 - 71,725,538 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	71,719,563 - 71,725,562 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	71,388,620 - 71,394,477 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	70,343,463 - 70,349,320 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	70,362,516 - 70,368,374 (+)	NCBI
Celera	8	65,993,837 - 65,999,694 (+)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

PPIB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	53,411,365 - 53,418,816 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	57,585,689 - 57,592,998 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	43,108,139 - 43,115,470 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	61,400,275 - 61,406,758 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	61,400,272 - 61,406,758 (-)	Ensembl	panpan1.1		panPan2

PPIB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	28,654,193 - 28,660,129 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	28,654,200 - 28,788,801 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	28,573,442 - 28,579,364 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	28,830,352 - 28,836,280 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	28,830,352 - 28,836,229 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	28,764,458 - 28,770,385 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	28,826,745 - 28,832,670 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	29,065,950 - 29,071,877 (-)	NCBI		UU_Cfam_GSD_1.0

Ppib
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	106,785,707 - 106,792,093 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	24,632,311 - 24,640,316 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	24,633,769 - 24,640,246 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PPIB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	107,886,658 - 107,893,253 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	107,886,663 - 107,893,155 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	118,800,893 - 118,806,498 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PPIB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	19,380,496 - 19,399,596 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666048	122,005,937 - 122,012,943 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ppib
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624781	8,402,430 - 8,411,003 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624781	8,402,518 - 8,407,950 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005393760	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01042652	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCE01002181	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000016373 ⟹ ENSCLAP00000016209

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955450	11,241,279 - 11,249,056 (+)	Ensembl

RefSeq Acc Id:

XM_005393760 ⟹ XP_005393817

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955450	11,241,279 - 11,246,628 (+)	NCBI

Sequence:

show sequence

GCCTCCCACAGCCCCGGGGACCCCCGCGCGGTGGCGGCGCCCGGCCACGCTGCCGCGTCCCCAC
CCTTTCCGGCCTGGCCGCCCGGCCCTGCACTCCCCCGGTGTGGATGCTGCGCTTCTCCGAGCGC
AACATGAAGCTGCTCTTCGCTGCCGCCCTCATCGTGGGCTCTGTCTTCTTCCTGCTGCTCCCGG
GGCCCTCCGCGGCCGACGAGAAGAAGAAGGGGCCTAAAGTCACCGTCAAGGTGTATTTTGACCT
ACGAATTGGAGATGAAGACGTGGGCCGGGTGGTCTTTGGTCTCTTTGGGAAGACTGTTCCAAAA
ACAGTGGATAATTTTGTGGCCTTAGCTACGGGAGAGAAAGGCTTTGGCTACAAAAACAGCAAAT
TCCATCGGGTGATCAAAGACTTCATGATCCAGGGCGGAGACTTCACCAGAGGAGATGGCACCGG
AGGCAAGAGCATCTACGGTGAGCGCTTCCCGGACGAGAACTTCAAGCTGAAGCACTACGGGCCC
GGCTGGGTGAGCATGGCCAACGCTGGCAAAGACACCAACGGCTCCCAGTTCTTCATCACTACCG
TCAAGACAGCCTGGCTCGATGGCAAGCACGTGGTATTCGGCAAGGTTCTGGAGGGCATGGAGGT
GGTGCGGAAGGTGGAGAGCACCAAGACAGACAGTCGGGACAAGCCCCTGAAGGACGTGATCATC
GCAGACTGCGGCAAAATCGAGGTGGAGAAGCCCTTTGCCATCGCCAAGGAGTAGGGCGCCAGGG
ACCTCTGCCCTCCATGTGACCATCTGCGCCAGCCTCGCTGCCCTCATGAGGGCGAAGATAGCCC
GGCCCAGGGCTCCGTGCTGCACTGGCCTGGTGCTGGCACCGACTGAGTGGACCACTCACCTCAC
ATTCCGCAGGCCCAATTTTGTAACAAACTACTGGTATCACTGCTGACCAATAAAACAAGTGAGG
TTTTTTTATAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005393817	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000016209
	ENSCLAP00000016209.1

RefSeq Acc Id:

XP_005393817 ⟸ XM_005393760

- UniProtKB:

A0A8C2VQE9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLRFSERNMKLLFAAALIVGSVFFLLLPGPSAADEKKKGPKVTVKVYFDLRIGDEDVGRVVFGL
FGKTVPKTVDNFVALATGEKGFGYKNSKFHRVIKDFMIQGGDFTRGDGTGGKSIYGERFPDENF
KLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDK
PLKDVIIADCGKIEVEKPFAIAKE

hide sequence

Ensembl Acc Id:

ENSCLAP00000016209 ⟸ ENSCLAT00000016373

Protein Domains

PPIase cyclophilin-type

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000011151	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000016373	ENTREZGENE
	ENSCLAT00000016373.1	UniProtKB/TrEMBL
Gene3D-CATH	2.40.100.10	UniProtKB/TrEMBL
InterPro	Cyclophilin-like_dom_sf	UniProtKB/TrEMBL
	Cyclophilin-type_PPIase_CS	UniProtKB/TrEMBL
	Cyclophilin-type_PPIase_dom	UniProtKB/TrEMBL
NCBI Gene	Ppib	ENTREZGENE
PANTHER	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE	UniProtKB/TrEMBL
	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE B	UniProtKB/TrEMBL
Pfam	Pro_isomerase	UniProtKB/TrEMBL
PRINTS	CSAPPISMRASE	UniProtKB/TrEMBL
PROSITE	CSA_PPIASE_1	UniProtKB/TrEMBL
	CSA_PPIASE_2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50891	UniProtKB/TrEMBL
UniProt	A0A8C2VQE9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Ppib	peptidylprolyl isomerase B		peptidylprolyl isomerase B (cyclophilin B)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - PID (archival)

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - PID (archival)