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Gene: Agtr2 (angiotensin II receptor type 2) Chinchilla lanigera

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Symbol:

Agtr2

Name:

angiotensin II receptor type 2

RGD ID:

8785225

Description:

ENCODES a protein that exhibits angiotensin type II receptor activity (ortholog); transcription factor binding (ortholog); INVOLVED IN angiotensin-activated signaling pathway (ortholog); angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure (ortholog); brain renin-angiotensin system (ortholog); PARTICIPATES IN angiotensin II signaling pathway; angiotensin II signaling pathway via AT2 receptor; angiotensin III signaling pathway; ASSOCIATED WITH AIDS-Associated Nephropathy (ortholog); Alveolar Bone Loss (ortholog); asthma (ortholog); FOUND IN perinuclear region of cytoplasm (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

angiotensin II receptor, type 2; type-2 angiotensin II receptor

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955534	3,653,157 - 3,654,248 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955534	3,653,112 - 3,654,248 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

AIDS-Associated Nephropathy (ISO)

Alveolar Bone Loss (ISO)

asthma (ISO)

autistic disorder (ISO)

autosomal hemophilia A (ISO)

Brain Hypoxia-Ischemia (ISO)

breast lobular carcinoma (ISO)

chronic kidney disease (ISO)

congenital diaphragmatic hernia (ISO)

congestive heart failure (ISO)

Diabetic Cardiomyopathies (ISO)

Diabetic Nephropathies (ISO)

dilated cardiomyopathy (ISO)

end stage renal disease (ISO)

Endotoxemia (ISO)

Experimental Diabetes Mellitus (ISO)

Experimental Mammary Neoplasms (ISO)

Experimental Radiation Injuries (ISO)

factor VIII deficiency (ISO)

Fetal Growth Retardation (ISO)

Fibrosis (ISO)

focal segmental glomerulosclerosis (ISO)

glomerulonephritis (ISO)

glomerulosclerosis (ISO)

hypertension (ISO)

hypoglycemia (ISO)

IgA glomerulonephritis (ISO)

Inflammation (ISO)

Insulin Resistance (ISO)

intellectual disability (ISO)

Left Ventricular Hypertrophy (ISO)

meconium aspiration syndrome (ISO)

Neoplasm Metastasis (ISO)

non-syndromic X-linked intellectual disability 88 (ISO)

obesity (ISO)

ovarian cyst (ISO)

pancreatic cancer (ISO)

Prenatal Exposure Delayed Effects (ISO)

pulmonary fibrosis (ISO)

renal cell carcinoma (ISO)

renovascular hypertension (ISO)

Reperfusion Injury (ISO)

Stomach Neoplasms (ISO)

Stroke (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

systemic lupus erythematosus (ISO)

type 2 diabetes mellitus (ISO)

Urogenital Abnormalities (ISO)

Vascular System Injuries (ISO)

vesicoureteral reflux (ISO)

X-Linked Intellectual Developmental Disorders (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

angiotensin-activated signaling pathway (ISO)

angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure (ISO)

brain renin-angiotensin system (ISO)

cell growth involved in cardiac muscle cell development (ISO)

cell surface receptor signaling pathway (ISO)

cellular response to dexamethasone stimulus (ISO)

cerebellar cortex development (ISO)

dopamine biosynthetic process (ISO)

exploration behavior (ISO)

G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (ISO)

inflammatory response (ISO)

intracellular sodium ion homeostasis (ISO)

kidney development (ISO)

kidney morphogenesis (ISO)

negative regulation of fibroblast proliferation (ISO)

negative regulation of heart rate (ISO)

negative regulation of icosanoid secretion (ISO)

negative regulation of neuron apoptotic process (ISO)

negative regulation of neurotrophin TRK receptor signaling pathway (ISO)

negative regulation of norepinephrine secretion (ISO)

neuron apoptotic process (ISO)

nitric oxide-cGMP-mediated signaling (ISO)

positive regulation of branching involved in ureteric bud morphogenesis (ISO)

positive regulation of cell population proliferation (ISO)

positive regulation of cytokine production (ISO)

positive regulation of DNA-templated transcription (ISO)

positive regulation of extrinsic apoptotic signaling pathway (ISO)

positive regulation of metanephric glomerulus development (ISO)

regulation of metanephros size (ISO)

regulation of protein import into nucleus (ISO)

regulation of systemic arterial blood pressure by circulatory renin-angiotensin (ISO)

renin-angiotensin regulation of aldosterone production (ISO)

vasodilation (ISO)

Cellular Component

perinuclear region of cytoplasm (ISO)

Molecular Function

angiotensin type II receptor activity (ISO)

protein binding (ISO)

transcription factor binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

angiotensin II signaling pathway (ISO)

angiotensin II signaling pathway via AT2 receptor (ISO)

angiotensin III signaling pathway (ISO)

angiotensin III signaling pathway via AT2 receptor (ISO)

G protein mediated signaling pathway via Galphai family (ISO)

renin-angiotensin cascade pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Agtr2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955534	3,653,157 - 3,654,248 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955534	3,653,112 - 3,654,248 (-)	NCBI	ChiLan1.0	ChiLan1.0

AGTR2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	116,170,744 - 116,174,974 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	116,170,744 - 116,174,974 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	115,301,997 - 115,306,227 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	115,215,986 - 115,220,253 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	115,113,884 - 115,117,702	NCBI
Celera	X	115,832,555 - 115,836,822 (-)	NCBI		Celera
Cytogenetic Map	X	q23	NCBI
HuRef	X	104,838,955 - 104,843,260 (+)	NCBI		HuRef
CHM1_1	X	115,212,791 - 115,217,059 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	114,580,328 - 114,584,558 (+)	NCBI		T2T-CHM13v2.0

Agtr2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	21,350,863 - 21,355,072 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	21,350,783 - 21,355,403 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	21,484,624 - 21,488,833 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	21,484,544 - 21,489,164 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	21,061,752 - 21,065,957 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	20,641,585 - 20,646,123 (+)	NCBI		MGSCv36	mm8
Celera	X	19,607,387 - 19,611,593 (+)	NCBI		Celera
Cytogenetic Map	X	A2	NCBI
cM Map	X	16.71	NCBI

Agtr2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	116,914,320 - 116,918,504 (+)	NCBI		GRCr8
mRatBN7.2	X	112,119,876 - 112,124,060 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	112,120,228 - 112,124,057 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	114,138,672 - 114,139,763 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	117,629,475 - 117,630,566 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	115,194,251 - 115,195,342 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	119,389,480 - 119,393,845 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	119,390,013 - 119,393,842 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	119,534,483 - 119,538,667 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	X	111,375,374 - 111,376,465 (+)	NCBI		Celera
Cytogenetic Map	X	q34	NCBI

AGTR2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	115,602,235 - 115,606,464 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	115,605,843 - 115,610,072 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	105,252,903 - 105,257,171 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	115,670,022 - 115,674,287 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	115,671,594 - 115,672,685 (+)	Ensembl	panpan1.1		panPan2

AGTR2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	88,703,551 - 88,708,451 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	88,705,765 - 88,706,853 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	74,841,362 - 74,845,718 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	90,431,596 - 90,435,944 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	90,433,258 - 90,434,346 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	87,892,846 - 87,897,203 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	89,651,006 - 89,655,363 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	89,385,692 - 89,390,050 (+)	NCBI		UU_Cfam_GSD_1.0

Agtr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	87,731,904 - 87,736,189 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936479	13,252,678 - 13,255,570 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936479	13,252,678 - 13,255,570 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AGTR2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	95,269,300 - 95,270,388 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	95,267,709 - 95,272,237 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	109,822,530 - 109,826,739 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AGTR2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Vero_WHO_p1.0	NW_023666065	28,955,602 - 28,958,335 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Agtr2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624967	329,284 - 330,372 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624967	327,627 - 332,000 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013507702	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01070589	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000025773 ⟹ ENSCLAP00000025512

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955534	3,653,157 - 3,654,248 (-)	Ensembl

RefSeq Acc Id:

XM_013507702 ⟹ XP_013363156

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955534	3,653,112 - 3,654,248 (-)	NCBI

Sequence:

show sequence

ATGAAGGGCAATTTCACTTTTGCCACCATCAGCCAAAACATTACCAACAGTCTGCACTTCAGAC
TTGTGAACATATCTGGCAGCAACGAGTCCACCTTTAACTGCTCACAAAAACCATCAGATAAGCA
TTTAGATGTGATTCCTATTCTCTACTACACTGTTTTTGTGATTGGATTTCTTGTTAATACTGTT
GTGGTTATGCTGTTTTGTTGTCAAAAGGGTCCTAAAAAGGTTTCCAGCATTTACATCTTCAACT
TGGCTGTGGCTGACTTACTCCTTTTGGCTACTCTTCCTCTCTGGGCAACCTACTATTCTCACAG
ATATGACTGGTTCTTTGGACCTATGATGTGCAAAGTTTTTGGTTCTTTTCTGACCCTAAACATG
TTTGCAAGCATTTTTTTTATTACCTGCATGAGTGTTGATAGGTATCAATCTGTCATCTCCCCCT
TTCTGTCTCAAAGAAGAAATCCATGGCAAGCATCTTACATAGTTCCCTTTGTGTGGTGTATGGC
CTGTCTCTCTTCATTGCCAACGTTTTATTTCCGAGATGTCAGAACCATTGAATACTTCGGAGTG
AATGCTTGCATTATGGCCTTCCCACCTGAGAAATACGCCCAATGGTCAGCTGGGATTGCCTTAA
TGAAAAATATCCTTGGTTTTATTATTCCTTTAATATTCATAGCAACATGCTACTTTGGTATCAG
AAAACACTTACTAAAGACCAACAGCTACGGGAAGAACAGAATAACCCGTGACCAAGTCCTGAAA
ATGGCAGCTGCTGTTGTACTGGCCTTCGTCATTTGCTGGCTTCCCTTCCACGTCCTAACTTTCT
TGGATGCTCTGGCCTGGATGGGTGTCATCCATAGCTGTGAAGTCACGGCAGTCATTGACTTGGC
ACTTCCCTTTGCCATCATTCTGGGATTCACCAACAGCTGCATTAATCCTTTTCTGTATTGTTTT
GTAGGAAACCGCTTCCAACAGAAGCTCCAAAGTATAGTTAGGGTCCCAAATACTTGGCTTCAAA
GCAAGAGAGAGACTATGTCTTGCAGAAAAAGCAGTTCTTTTAGAGAAATGGACACTTTTGTGTC
TCAAACCCAAGAGTGCAATGCCTGTTATCAAAGTGGCAACTTGTTTTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_013363156	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000025512
	ENSCLAP00000025512.1

RefSeq Acc Id:

XP_013363156 ⟸ XM_013507702

- UniProtKB:

A0A8C2WAK4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKGNFTFATISQNITNSLHFRLVNISGSNESTFNCSQKPSDKHLDVIPILYYTVFVIGFLVNTV
VVMLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSHRYDWFFGPMMCKVFGSFLTLNM
FASIFFITCMSVDRYQSVISPFLSQRRNPWQASYIVPFVWCMACLSSLPTFYFRDVRTIEYFGV
NACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLK
MAAAVVLAFVICWLPFHVLTFLDALAWMGVIHSCEVTAVIDLALPFAIILGFTNSCINPFLYCF
VGNRFQQKLQSIVRVPNTWLQSKRETMSCRKSSSFREMDTFVSQTQECNACYQSGNLF

hide sequence

Ensembl Acc Id:

ENSCLAP00000025512 ⟸ ENSCLAT00000025773

Protein Domains

G-protein coupled receptors family 1 profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000017599	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000025773	ENTREZGENE
	ENSCLAT00000025773.1	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	ATII_AT2_rcpt	UniProtKB/TrEMBL
	ATII_rcpt	UniProtKB/TrEMBL
	GPCR1	UniProtKB/TrEMBL
	GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/TrEMBL
NCBI Gene	Agtr2	ENTREZGENE
PANTHER	CELL ADHESION MOLECULE	UniProtKB/TrEMBL
	TYPE-2 ANGIOTENSIN II RECEPTOR	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
PRINTS	ANGIOTENSINR	UniProtKB/TrEMBL
	ANGIOTENSN2R	UniProtKB/TrEMBL
	GPCRRHODOPSN	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	A0A8C2WAK4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Agtr2	angiotensin II receptor type 2		angiotensin II receptor, type 2	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations