Cacna1h (calcium voltage-gated channel subunit alpha1 H) - Rat Genome Database

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Gene: Cacna1h (calcium voltage-gated channel subunit alpha1 H) Chinchilla lanigera
Analyze
Symbol: Cacna1h
Name: calcium voltage-gated channel subunit alpha1 H
RGD ID: 8764373
Description: ENCODES a protein that exhibits low voltage-gated calcium channel activity (ortholog); scaffold protein binding (ortholog); voltage-gated calcium channel activity (ortholog); INVOLVED IN aldosterone biosynthetic process (ortholog); calcium ion import (ortholog); calcium ion transport (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH arteriovenous malformations of the brain (ortholog); autistic disorder (ortholog); beta thalassemia (ortholog); FOUND IN caveola (ortholog); dendrite (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: calcium channel, voltage-dependent, T type, alpha 1H subunit; voltage-dependent T-type calcium channel subunit alpha-1H
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544216,045,895 - 16,108,862 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544216,047,965 - 16,108,862 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway   (ISO)
calcium transport pathway   (ISO)
calcium/calcium-mediated signaling pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Cacna1h
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544216,045,895 - 16,108,862 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544216,047,965 - 16,108,862 (-)NCBIChiLan1.0ChiLan1.0
CACNA1H
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38161,153,106 - 1,221,768 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl161,153,103 - 1,224,169 (+)EnsemblGRCh38hg38GRCh38
GRCh37161,203,106 - 1,271,768 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36161,143,242 - 1,211,773 (+)NCBINCBI36Build 36hg18NCBI36
Build 34161,143,241 - 1,211,772NCBI
Celera161,418,957 - 1,487,666 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef161,111,743 - 1,204,831 (+)NCBIHuRef
CHM1_1161,179,129 - 1,271,446 (+)NCBICHM1_1
T2T-CHM13v2.0161,165,753 - 1,237,078 (+)NCBIT2T-CHM13v2.0
Cacna1h
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391725,593,259 - 25,655,308 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1725,593,259 - 25,652,759 (-)EnsemblGRCm39 Ensembl
GRCm381725,374,285 - 25,436,334 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1725,374,285 - 25,433,783 (-)EnsemblGRCm38mm10GRCm38
MGSCv371725,511,232 - 25,570,728 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361725,101,887 - 25,161,368 (-)NCBIMGSCv36mm8
Celera1725,902,087 - 25,961,468 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.53NCBI
Cacna1h
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,894,630 - 14,952,317 (-)NCBIGRCr8
mRatBN7.21014,390,104 - 14,448,204 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,390,113 - 14,448,376 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1019,130,825 - 19,188,496 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01018,619,694 - 18,677,363 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01014,118,873 - 14,176,544 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01014,730,932 - 14,789,201 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,730,941 - 14,788,617 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01014,547,456 - 14,605,627 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41014,621,372 - 14,679,051 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11014,621,371 - 14,679,051 (-)NCBI
Celera1014,061,778 - 14,119,454 (-)NCBICelera
Cytogenetic Map10q12NCBI
CACNA1H
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2181,406,005 - 1,477,547 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1165,187,949 - 5,257,891 (+)NCBINHGRI_mPanPan1
PanPan1.1161,195,991 - 1,222,917 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl161,195,364 - 1,222,917 (+)Ensemblpanpan1.1panPan2
CACNA1H
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1639,510,129 - 39,533,129 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl639,510,121 - 39,533,753 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha640,776,915 - 40,826,321 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0639,855,337 - 39,904,743 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl639,855,796 - 39,878,507 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1639,531,855 - 39,581,243 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0639,504,487 - 39,553,874 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0639,983,132 - 40,032,548 (-)NCBIUU_Cfam_GSD_1.0
Cacna1h
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344103,984,951 - 104,007,239 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366942,702,224 - 2,724,574 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CACNA1H
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl340,637,427 - 40,695,177 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1340,637,420 - 40,694,616 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CACNA1H
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.151,039,709 - 1,106,212 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl51,078,973 - 1,106,507 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606829,985,587 - 30,052,739 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cacna1h
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249131,891,156 - 1,949,633 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249131,926,405 - 1,952,426 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000020614   ⟹   ENSCLAP00000020416
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495544216,045,895 - 16,108,862 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000020615   ⟹   ENSCLAP00000020417
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495544216,048,719 - 16,108,313 (-)Ensembl
RefSeq Acc Id: XM_013517978   ⟹   XP_013373432
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544216,047,965 - 16,108,862 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013517979   ⟹   XP_013373433
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544216,047,965 - 16,108,862 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013517980   ⟹   XP_013373434
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544216,047,965 - 16,108,862 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013517981   ⟹   XP_013373435
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544216,047,965 - 16,108,862 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013517982   ⟹   XP_013373436
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544216,047,965 - 16,108,862 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013517983   ⟹   XP_013373437
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544216,047,965 - 16,108,862 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001235422
Type: NON-CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544216,049,668 - 16,108,862 (-)NCBI
Sequence:
RefSeq Acc Id: XP_013373437   ⟸   XM_013517983
- Peptide Label: isoform X6
- UniProtKB: A0A8C2YSP0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013373435   ⟸   XM_013517981
- Peptide Label: isoform X4
- UniProtKB: A0A8C2YSP0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013373433   ⟸   XM_013517979
- Peptide Label: isoform X2
- UniProtKB: A0A8C2YSP0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013373436   ⟸   XM_013517982
- Peptide Label: isoform X5
- UniProtKB: A0A8C2YSP0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013373434   ⟸   XM_013517980
- Peptide Label: isoform X3
- UniProtKB: A0A8C2YSP0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013373432   ⟸   XM_013517978
- Peptide Label: isoform X1
- UniProtKB: A0A8C2YSP0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000020416   ⟸   ENSCLAT00000020614
Ensembl Acc Id: ENSCLAP00000020417   ⟸   ENSCLAT00000020615
Protein Domains
Ion transport


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000013993 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000020614 ENTREZGENE
  ENSCLAT00000020614.1 UniProtKB/TrEMBL
  ENSCLAT00000020615 ENTREZGENE
  ENSCLAT00000020615.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/TrEMBL
InterPro Ion_trans_dom UniProtKB/TrEMBL
  VDCC_alpha-1_subunit UniProtKB/TrEMBL
  VDCC_T_a1 UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/TrEMBL
NCBI Gene Cacna1h ENTREZGENE
PANTHER VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 UniProtKB/TrEMBL
  VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1H UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/TrEMBL
PRINTS TVDCCALPHA1 UniProtKB/TrEMBL
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A8C2VTU6_CHILA UniProtKB/TrEMBL
  A0A8C2YSP0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Cacna1h  calcium voltage-gated channel subunit alpha1 H    calcium channel, voltage-dependent, T type, alpha 1H subunit  Symbol and/or name change 5135510 APPROVED