Ins (insulin) - Rat Genome Database

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Gene: Ins (insulin) Chinchilla lanigera
Analyze
Symbol: Ins
Name: insulin
RGD ID: 8746831
Description: ENCODES a protein that exhibits zinc ion binding; hormone activity (ortholog); identical protein binding (ortholog); INVOLVED IN protein hexamerization; acute-phase response (ortholog); alpha-beta T cell activation (ortholog); PARTICIPATES IN altered insulin signaling pathway; forkhead class A signaling pathway; gliclazide pharmacodynamics pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Liver Failure (ortholog); adenoma (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542213,909,407 - 13,910,419 (-)Ensembl
ChiLan1.0NW_00495542213,909,408 - 13,910,419 (-)NCBIChiLan1.0ChiLan1.0
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
adenoma  (ISO)
Albuminuria  (ISO)
Alzheimer's disease  (ISO)
Beckwith-Wiedemann syndrome  (ISO)
bipolar disorder  (ISO)
bladder disease  (ISO)
cardiac arrest  (ISO)
cholangiocarcinoma  (ISO)
cognitive disorder  (ISO)
congestive heart failure  (ISO)
cystic kidney disease  (ISO)
delta beta-thalassemia  (ISO)
developmental and epileptic encephalopathy  (ISO)
diabetes mellitus  (ISO)
Diabetic Cardiomyopathies  (ISO)
diabetic ketoacidosis  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
disease of metabolism  (ISO)
Edema  (ISO)
Experimental Liver Cirrhosis  (ISO)
generalized dystonia  (ISO)
genetic disease  (ISO)
gestational diabetes  (ISO)
glucose intolerance  (ISO)
hepatitis  (ISO)
hepatocellular carcinoma  (ISO)
hyperglycemia  (ISO)
hyperinsulinism  (ISO)
Hyperkalemia  (ISO)
Hyperproinsulinemia  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
hypertrophic cardiomyopathy  (ISO)
hyperuricemia  (ISO)
hypoglycemia  (ISO)
Hypoinsulinemia  (ISO)
hypokalemia  (ISO)
Hypotension  (ISO)
immunodeficiency 39  (ISO)
Insulin Resistance  (ISO)
insulinoma  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Lewy body dementia  (ISO)
liver disease  (ISO)
maturity-onset diabetes of the young  (ISO)
maturity-onset diabetes of the young type 1  (ISO)
maturity-onset diabetes of the young type 10  (ISO)
Memory Disorders  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
Micronuclei, Chromosome-Defective  (ISO)
MPTP Poisoning  (ISO)
muscular disease  (ISO)
neonatal diabetes mellitus  (ISO)
Neoplasm Invasiveness  (ISO)
neural tube defect  (ISO)
neuronal ceroid lipofuscinosis  (ISO)
obesity  (ISO)
osteoarthritis  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
pancreatitis  (ISO)
panic disorder  (ISO)
Paralysis  (ISO)
Paresthesia  (ISO)
Parkinson's disease  (ISO)
permanent neonatal diabetes mellitus  (ISO)
Permanent Neonatal Diabetes Mellitus 4  (ISO)
Phelan-McDermid syndrome  (ISO)
polycystic ovary syndrome  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
Rhabdomyolysis  (ISO)
Segawa Syndrome, Autosomal Recessive  (ISO)
steatotic liver disease  (ISO)
Tachycardia  (ISO)
transient neonatal diabetes mellitus  (ISO)
type 1 diabetes mellitus  (ISO)
type 1 diabetes mellitus 2  (ISO)
type 2 diabetes mellitus  (ISO)
Type 2 Diabetes Mellitus 1  (ISO)
Ventricular Dysfunction, Left  (ISO)
Ventricular Fibrillation  (ISO)
Ventricular Outflow Obstruction  (ISO)
Weight Loss  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (ISO)
alpha-beta T cell activation  (ISO)
ER overload response  (ISO)
fatty acid homeostasis  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
glucose homeostasis  (ISO)
glucose metabolic process  (ISO)
glycoprotein biosynthetic process  (ISO)
insulin processing  (ISO)
insulin receptor signaling pathway  (ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (ISO)
lactate biosynthetic process  (ISO)
lipid biosynthetic process  (ISO)
lipid catabolic process  (ISO)
lipoprotein biosynthetic process  (ISO)
myoblast fusion  (ISO)
myotube differentiation  (ISO)
negative regulation of acute inflammatory response  (ISO)
negative regulation of fatty acid metabolic process  (ISO)
negative regulation of feeding behavior  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of gluconeogenesis  (ISO)
negative regulation of glycogen catabolic process  (ISO)
negative regulation of lipid catabolic process  (ISO)
negative regulation of protein catabolic process  (ISO)
negative regulation of protein secretion  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
negative regulation of respiratory burst involved in inflammatory response  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of ubiquitin-dependent protein catabolic process  (ISO)
neuron projection maintenance  (ISO)
nitric oxide-cGMP-mediated signaling  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of D-glucose import  (ISO)
positive regulation of dendritic spine maintenance  (ISO)
positive regulation of DNA replication  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fatty acid biosynthetic process  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glucose metabolic process  (ISO)
positive regulation of glycogen biosynthetic process  (ISO)
positive regulation of glycolytic process  (ISO)
positive regulation of insulin receptor signaling pathway  (ISO)
positive regulation of lipid kinase activity  (ISO)
positive regulation of lipoprotein lipase activity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of nitric oxide mediated signal transduction  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of respiratory burst  (ISO)
positive regulation of translation  (ISO)
protein hexamerization  (IDA)
receptor internalization  (ISO)
regulation of gene expression  (ISO)
regulation of phosphorylation  (ISO)
regulation of protein localization  (ISO)
regulation of protein localization to plasma membrane  (ISO)
regulation of protein secretion  (ISO)
TORC1 signaling  (ISO)
vasodilation  (ISO)
wound healing  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. The relation of conformation and association of insulin to receptor binding; x-ray and circular-dichroism studies on bovine and hystricomorph insulins. Wood SP, etal., Eur J Biochem. 1975 Jul 15;55(3):531-42.
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ins
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542213,909,407 - 13,910,419 (-)Ensembl
ChiLan1.0NW_00495542213,909,408 - 13,910,419 (-)NCBIChiLan1.0ChiLan1.0
INS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38112,159,779 - 2,161,209 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl112,159,779 - 2,161,221 (-)Ensemblhg38GRCh38
GRCh37112,181,009 - 2,182,439 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,137,585 - 2,139,015 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34112,137,584 - 2,139,000NCBI
Celera112,217,516 - 2,218,946 (-)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef111,971,272 - 1,972,702 (-)NCBIHuRef
CHM1_1112,179,957 - 2,181,387 (-)NCBICHM1_1
T2T-CHM13v2.0112,247,427 - 2,248,857 (-)NCBIT2T-CHM13v2.0
Ins2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397142,232,393 - 142,233,463 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7142,232,393 - 142,297,118 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm387142,678,656 - 142,679,726 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7142,678,656 - 142,743,381 (-)Ensemblmm10GRCm38
MGSCv377149,864,561 - 149,865,613 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367142,488,051 - 142,489,098 (-)NCBIMGSCv36mm8
Celera7142,434,985 - 142,436,037 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.0NCBI
Ins2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81207,272,738 - 207,421,998 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1207,272,742 - 207,273,805 (-)EnsemblGRCr8
mRatBN7.21197,843,277 - 197,992,522 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1197,843,281 - 197,864,775 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1206,216,147 - 206,217,214 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01213,302,063 - 213,303,130 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01205,976,222 - 205,977,289 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01215,856,967 - 215,858,034 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1215,856,971 - 215,858,034 (-)Ensemblrn6Rnor6.0
Rnor_5.01222,751,786 - 222,756,821 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41202,935,548 - 202,936,379 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1195,461,309 - 195,462,376 (-)NCBICelera
RGSC_v3.11203,123,613 - 203,124,445 (-)NCBI
Cytogenetic Map1q41NCBI
INS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v294,586,153 - 4,587,845 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1113,797,924 - 3,799,616 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0112,200,785 - 2,202,579 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1112,230,309 - 2,231,666 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl112,218,117 - 2,231,666 (-)EnsemblpanPan2panpan1.1
INS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11846,324,047 - 46,324,933 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1846,324,041 - 46,325,122 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1844,933,843 - 44,934,720 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01847,003,520 - 47,004,406 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1847,003,520 - 47,004,411 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11846,452,280 - 46,453,156 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01846,032,597 - 46,033,483 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01846,779,045 - 46,779,926 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ins
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049471,748,017 - 1,749,237 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368161,002,137 - 1,003,357 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049368161,002,137 - 1,003,357 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl21,496,842 - 1,497,841 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.121,496,842 - 1,498,052 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
INS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111,965,128 - 1,969,090 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603899,163,059 - 99,164,540 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ins
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476714,999,088 - 15,000,035 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476714,999,088 - 15,000,035 (-)NCBIHetGla 1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000023305   ⟹   ENSCLAP00000023087
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542213,909,407 - 13,910,419 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000023306   ⟹   ENSCLAP00000023088
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542213,909,467 - 13,910,419 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000023307   ⟹   ENSCLAP00000023089
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542213,909,655 - 13,910,419 (-)Ensembl
RefSeq Acc Id: XM_005384189   ⟹   XP_005384246
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542213,909,408 - 13,910,419 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005384246 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAX33327 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000023087.1
  ENSCLAP00000023088.1
  ENSCLAP00000023089.1
RefSeq Acc Id: XP_005384246   ⟸   XM_005384189
- UniProtKB: A0A8C2W4I8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000023088   ⟸   ENSCLAT00000023306
Ensembl Acc Id: ENSCLAP00000023089   ⟸   ENSCLAT00000023307
Ensembl Acc Id: ENSCLAP00000023087   ⟸   ENSCLAT00000023305
Protein Domains
Insulin-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000015849 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000023305.1 UniProtKB/TrEMBL
  ENSCLAT00000023306.1 UniProtKB/TrEMBL
  ENSCLAT00000023307.1 UniProtKB/TrEMBL
Gene3D-CATH Insulin-like UniProtKB/TrEMBL
InterPro Insulin UniProtKB/TrEMBL
  Insulin-like UniProtKB/TrEMBL
  Insulin-like_sf UniProtKB/TrEMBL
  Insulin_CS UniProtKB/TrEMBL
  Insulin_family UniProtKB/TrEMBL
NCBI Gene Ins ENTREZGENE
PANTHER INSULIN UniProtKB/TrEMBL
  PTHR11454 UniProtKB/TrEMBL
Pfam Insulin UniProtKB/TrEMBL
PRINTS INSULIN UniProtKB/TrEMBL
  INSULINFAMLY UniProtKB/TrEMBL
PROSITE INSULIN UniProtKB/TrEMBL
SMART IlGF UniProtKB/TrEMBL
Superfamily-SCOP SSF56994 UniProtKB/TrEMBL
UniProt A0A8C2W2Q8_CHILA UniProtKB/TrEMBL
  A0A8C2W4I8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2W6V2_CHILA UniProtKB/TrEMBL