Cx3cl1 (C-X3-C motif chemokine ligand 1) - Rat Genome Database

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Gene: Cx3cl1 (C-X3-C motif chemokine ligand 1) Chinchilla lanigera
Analyze
Symbol: Cx3cl1
Name: C-X3-C motif chemokine ligand 1
RGD ID: 8718124
Description: ENCODES a protein that exhibits chemoattractant activity (ortholog); chemokine activity (ortholog); CX3C chemokine receptor binding (ortholog); INVOLVED IN angiogenesis involved in wound healing (ortholog); autocrine signaling (ortholog); cell adhesion (ortholog); ASSOCIATED WITH acute pancreatitis (ortholog); allergic disease (ortholog); anti-basement membrane glomerulonephritis (ortholog); FOUND IN cell body (ortholog); cell projection (ortholog); cell surface (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: chemokine (C-X3-C motif) ligand 1; fractalkine
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543315,023,050 - 15,034,711 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543315,023,272 - 15,034,650 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute pancreatitis  (ISO)
allergic disease  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
Bardet-Biedl syndrome  (ISO)
borna disease  (ISO)
Chromosome 16q12 Duplication Syndrome  (ISO)
chronic fatigue syndrome  (ISO)
Chronic Mesangial Proliferative Glomerulonephritis  (ISO)
common cold  (ISO)
Cor pulmonale  (ISO)
Cranial Nerve Injuries  (ISO)
cystitis  (ISO)
dermatomyositis  (ISO)
developmental and epileptic encephalopathy  (ISO)
early infantile epileptic encephalopathy  (ISO)
Endotoxemia  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
glomerulonephritis  (ISO)
Hearing Loss  (ISO)
hepatopulmonary syndrome  (ISO)
Hyperalgesia  (ISO)
Intervertebral Disc Displacement  (ISO)
ischemia  (ISO)
Legionnaires' disease  (ISO)
lung disease  (ISO)
Microscopic Polyangiitis  (ISO)
Myocardial Ischemia  (ISO)
myocarditis  (ISO)
nephrosis  (ISO)
Paramyxoviridae Infections  (ISO)
Parkinsonism  (ISO)
Periapical Diseases  (ISO)
pneumonia  (ISO)
polyarteritis nodosa  (ISO)
polymyositis  (ISO)
portal hypertension  (ISO)
prion disease  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary embolism  (ISO)
pulmonary emphysema  (ISO)
pulmonary hypertension  (ISO)
Reperfusion Injury  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
status epilepticus  (ISO)
systemic scleroderma  (ISO)
transient cerebral ischemia  (ISO)
uveitis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis involved in wound healing  (ISO)
autocrine signaling  (ISO)
cell adhesion  (ISO)
cell chemotaxis  (ISO)
cell-cell adhesion  (ISO)
cellular response to tumor necrosis factor  (ISO)
chemokine-mediated signaling pathway  (ISO)
chemotaxis  (ISO)
cytokine-mediated signaling pathway  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
inhibitory postsynaptic potential  (ISO)
integrin activation  (ISO)
leukocyte migration involved in inflammatory response  (ISO)
lymphocyte chemotaxis  (ISO)
microglial cell activation  (ISO)
microglial cell proliferation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
negative regulation of glutamate receptor signaling pathway  (ISO)
negative regulation of hippocampal neuron apoptotic process  (ISO)
negative regulation of interleukin-1 alpha production  (ISO)
negative regulation of microglial cell activation  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of vasoconstriction  (ISO)
neuron cellular homeostasis  (ISO)
neutrophil chemotaxis  (ISO)
positive chemotaxis  (ISO)
positive regulation of actin filament bundle assembly  (ISO)
positive regulation of calcium-independent cell-cell adhesion  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of macrophage chemotaxis  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of microglial cell migration  (ISO)
positive regulation of neuroblast proliferation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of release of sequestered calcium ion into cytosol  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transforming growth factor beta1 production  (ISO)
regulation of lipopolysaccharide-mediated signaling pathway  (ISO)
response to hypoxia  (ISO)
response to ischemia  (ISO)
wound healing  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Cx3cl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543315,023,050 - 15,034,711 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543315,023,272 - 15,034,650 (+)NCBIChiLan1.0ChiLan1.0
CX3CL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381657,372,490 - 57,385,044 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1657,372,477 - 57,385,044 (+)EnsemblGRCh38hg38GRCh38
GRCh371657,406,402 - 57,418,956 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361655,963,915 - 55,976,457 (+)NCBINCBI36Build 36hg18NCBI36
Build 341655,963,914 - 55,976,455NCBI
Celera1641,906,410 - 41,918,956 (+)NCBICelera
Cytogenetic Map16q21NCBI
HuRef1643,274,294 - 43,286,836 (+)NCBIHuRef
CHM1_11658,814,629 - 58,827,168 (+)NCBICHM1_1
T2T-CHM13v2.01663,167,607 - 63,180,165 (+)NCBIT2T-CHM13v2.0
Cx3cl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39895,498,808 - 95,509,055 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl895,498,637 - 95,509,055 (+)EnsemblGRCm39 Ensembl
GRCm38894,772,180 - 94,782,427 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl894,772,009 - 94,782,427 (+)EnsemblGRCm38mm10GRCm38
MGSCv37897,296,080 - 97,306,327 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36897,661,355 - 97,671,556 (+)NCBIMGSCv36mm8
Celera899,100,414 - 99,110,655 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map846.79NCBI
Cx3cl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81910,233,326 - 10,244,856 (-)NCBIGRCr8
mRatBN7.21910,227,337 - 10,237,826 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,227,340 - 10,236,833 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1910,190,578 - 10,200,058 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01910,957,425 - 10,966,906 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,244,371 - 10,253,854 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01910,644,267 - 10,654,861 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1910,644,244 - 10,653,800 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01910,638,466 - 10,647,951 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41910,666,940 - 10,676,424 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11910,671,765 - 10,681,250 (-)NCBI
Celera1910,113,300 - 10,122,786 (-)NCBICelera
Cytogenetic Map19p13NCBI
CX3CL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21866,840,670 - 66,853,297 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11672,761,444 - 72,774,073 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01637,646,447 - 37,659,078 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11656,779,065 - 56,791,760 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1656,779,065 - 56,791,760 (+)Ensemblpanpan1.1panPan2
CX3CL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,022,794 - 59,032,095 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,022,794 - 59,032,095 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha255,652,232 - 55,661,533 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0259,561,127 - 59,570,437 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl259,559,167 - 59,570,279 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1256,392,704 - 56,402,005 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0257,400,382 - 57,409,687 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0258,293,678 - 58,302,979 (-)NCBIUU_Cfam_GSD_1.0
Cx3cl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934950,134,360 - 50,145,250 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364759,443,733 - 9,455,062 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364759,443,851 - 9,454,715 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CX3CL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1619,312,351 - 19,324,439 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2617,304,118 - 17,315,820 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CX3CL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1543,310,711 - 43,323,533 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl543,310,753 - 43,323,529 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604732,993,345 - 33,006,077 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cx3cl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474628,677,709 - 28,689,122 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474628,677,956 - 28,688,638 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000009303   ⟹   ENSCLAP00000009174
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495543315,023,050 - 15,034,711 (+)Ensembl
RefSeq Acc Id: XM_005388386   ⟹   XP_005388443
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543315,023,272 - 15,034,650 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005388387   ⟹   XP_005388444
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543315,023,286 - 15,034,650 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005388443 (Get FASTA)   NCBI Sequence Viewer  
  XP_005388444 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000009174
  ENSCLAP00000009174.1
RefSeq Acc Id: XP_005388443   ⟸   XM_005388386
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005388444   ⟸   XM_005388387
- Peptide Label: isoform X2
- UniProtKB: A0A8C2V871 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000009174   ⟸   ENSCLAT00000009303
Protein Domains
Chemokine interleukin-8-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000006390 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000009303 ENTREZGENE
  ENSCLAT00000009303.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.40 UniProtKB/TrEMBL
InterPro Chemokine_b/g/d UniProtKB/TrEMBL
  Chemokine_IL8-like_dom UniProtKB/TrEMBL
  Interleukin_8-like_sf UniProtKB/TrEMBL
NCBI Gene LOC102025717 ENTREZGENE
PANTHER PTHR12015 UniProtKB/TrEMBL
  PTHR12015:SF92 UniProtKB/TrEMBL
Pfam IL8 UniProtKB/TrEMBL
PRINTS FRACTALKINE UniProtKB/TrEMBL
SMART SCY UniProtKB/TrEMBL
Superfamily-SCOP SSF54117 UniProtKB/TrEMBL
UniProt A0A8C2V871 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Cx3cl1  C-X3-C motif chemokine ligand 1    chemokine (C-X3-C motif) ligand 1  Symbol and/or name change 5135510 APPROVED
2015-08-25 Cx3cl1  chemokine (C-X3-C motif) ligand 1  LOC102025717  c-C motif chemokine 17-like  Symbol and/or name change 5135510 APPROVED