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Gene: Cct4 (chaperonin containing TCP1 subunit 4) Chinchilla lanigera

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Symbol:

Cct4

Name:

chaperonin containing TCP1 subunit 4

RGD ID:

8706848

Description:

ENCODES a protein that exhibits protein folding chaperone (ortholog); INVOLVED IN binding of sperm to zona pellucida (ortholog); chaperone mediated protein folding independent of cofactor (ortholog); chaperone-mediated protein folding (ortholog); ASSOCIATED WITH hereditary sensory neuropathy (ortholog); schizophrenia (ortholog); FOUND IN cell body (ortholog); centrosome (ortholog); chaperonin-containing T-complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

chaperonin containing TCP1, subunit 4 (delta); T-complex protein 1 subunit delta

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955424	22,088,949 - 22,108,514 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955424	22,088,949 - 22,108,514 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hereditary sensory neuropathy (ISO)

schizophrenia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

binding of sperm to zona pellucida (ISO)

chaperone mediated protein folding independent of cofactor (ISO)

chaperone-mediated protein folding (ISO)

positive regulation of protein localization to Cajal body (ISO)

positive regulation of telomerase RNA localization to Cajal body (ISO)

positive regulation of telomere maintenance via telomerase (ISO)

protein folding (ISO)

protein stabilization (ISO)

scaRNA localization to Cajal body (ISO)

Cellular Component

cell body (ISO)

centrosome (ISO)

chaperonin-containing T-complex (ISO)

cytosol (ISO)

microtubule (ISO)

nucleoplasm (ISO)

zona pellucida receptor complex (ISO)

Molecular Function

protein binding (ISO)

protein folding chaperone (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Cct4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955424	22,088,949 - 22,108,514 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955424	22,088,949 - 22,108,514 (+)	NCBI	ChiLan1.0	ChiLan1.0

CCT4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	61,868,085 - 61,888,671 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	61,868,085 - 61,888,671 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	62,095,220 - 62,115,806 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	61,948,766 - 61,969,295 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	62,006,913 - 62,027,442	NCBI
Celera	2	61,940,173 - 61,960,736 (-)	NCBI		Celera
Cytogenetic Map	2	p15	NCBI
HuRef	2	61,835,217 - 61,855,722 (-)	NCBI		HuRef
CHM1_1	2	62,025,224 - 62,045,751 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	61,874,246 - 61,894,829 (-)	NCBI		T2T-CHM13v2.0

Cct4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	22,940,593 - 22,953,336 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	22,940,519 - 22,953,780 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	22,990,593 - 23,003,336 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	22,990,519 - 23,003,780 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	22,890,593 - 22,903,336 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	22,890,593 - 22,903,336 (+)	NCBI		MGSCv36	mm8
Celera	11	25,126,226 - 25,138,969 (+)	NCBI		Celera
Cytogenetic Map	11	A3.2	NCBI
cM Map	11	14.25	NCBI

Cct4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	101,193,057 - 101,205,935 (+)	NCBI		GRCr8
mRatBN7.2	14	96,991,853 - 97,004,732 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	96,991,859 - 97,005,267 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	101,325,100 - 101,337,974 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	102,567,399 - 102,580,273 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	99,039,002 - 99,051,876 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	107,767,392 - 107,780,270 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	107,767,392 - 107,780,270 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	107,843,411 - 107,856,260 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	103,675,110 - 103,687,893 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	103,694,320 - 103,707,104 (+)	NCBI
Celera	14	95,973,133 - 95,985,983 (+)	NCBI		Celera
Cytogenetic Map	14	q22	NCBI

CCT4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	64,495,636 - 64,516,010 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	64,499,652 - 64,519,655 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	61,950,477 - 61,970,783 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	63,084,090 - 63,104,530 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	63,084,090 - 63,105,216 (-)	Ensembl	panpan1.1		panPan2

CCT4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	61,859,148 - 61,874,030 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	61,859,245 - 61,874,389 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	61,748,927 - 61,763,778 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	62,867,889 - 62,882,584 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	62,867,244 - 62,882,587 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	62,551,782 - 62,566,434 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	62,855,534 - 62,870,428 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	63,151,020 - 63,165,931 (-)	NCBI		UU_Cfam_GSD_1.0

Cct4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	21,330,016 - 21,346,300 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936491	7,224,692 - 7,241,358 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936491	7,224,989 - 7,241,348 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CCT4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	79,924,507 - 79,946,207 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	79,924,338 - 79,941,926 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	83,760,065 - 83,777,463 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CCT4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	45,086,932 - 45,106,922 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	45,086,920 - 45,111,271 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	66,727,959 - 66,748,110 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cct4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624833	46,076 - 62,665 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624833	46,071 - 62,665 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005385733	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01024931	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01024932	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01024933	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01009053	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000021099 ⟹ ENSCLAP00000020898

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955424	22,088,949 - 22,108,514 (+)	Ensembl

Ensembl Acc Id:

ENSCLAT00000021100 ⟹ ENSCLAP00000020899

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955424	22,089,088 - 22,108,326 (+)	Ensembl

RefSeq Acc Id:

XM_005385733 ⟹ XP_005385790

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955424	22,088,949 - 22,108,514 (+)	NCBI

Sequence:

show sequence

CGCGCCTGCCTCCTCCCGGCGCCGGCGCCGCTTTCTGGAAGGTTCGAGAAGACGGTGTACGCAG
ACCGTTACAACGCGGCGAGGAGAATCTGTGTCCATCCGTGCTTGCTGAGTCCACGCAGACTTAG
TTGAACTTGCCATGCCAGAGAATTTGGCACCCCGGAGCGGGGCCCCCGCGGGTACTGCTGGCGG
CCGCGGGAAAAGCGCTTATCAGGACCGCGACAAGCCGGCCCAGATCCGCTTCAGCAACATTTCT
GCAGCCAAAGCTGTTGCTGATGCTATTAGAACAAGCCTTGGACCAAAAGGAATGGATAAAATGA
TTCAAGATGGAAAAGGTGATGTGACCATTACTAATGATGGTGCTACCATCCTGAAACAAATGCA
AGTGTTACATCCAGCAGCCAGAATGCTGGTGGAACTGTCTAAGGCTCAGGATATAGAAGCAGGA
GACGGCACCACGTCAGTGGTCATCATTGCTGGCTCTCTGTTAGATTCCTGTACCAAGCTTCTTC
AGAAAGGGATTCATCCAACCATCATTTCTGAGTCATTCCAGAAGGCTTTGGAAAAGGGTCTTGA
AATCTTGACTGGTATGTCTCGGCCGGTGGAACTGAGTGACAGAGAAACTTTGTTAAATAGTGCA
ACCACTTCATTGAACTCTAAGGTGGTCTCCCAGTATTCAAGTCTACTTTCTCCAATGAGTGTAA
ATGCGGTAATGAGAGTGATTGACCCTGCCACGGCTACTAGTGTAGATCTTAGAGATATTAAAAT
AGTTAAGAAGCTTGGTGGGACAATTGATGACTGTGAGTTGGTGGAAGGGCTAGTTCTTACCCAA
AAAGTGGCAAATTCCGGCTTAACCAGAGTTGAAAAGGCTAAGATTGGGCTCATTCAGTTTTGTT
TGTCTGCTCCCAAAACAGACATGGATAATCAAATAGTAGTTTCTGACTATGCCCAGATGGACCG
AGTACTGCGAGAAGAGAGAGCCTATATTTTAAATTTGGTGAAGCAAATTAAAAAAACGGGGTGT
AACGTCCTTCTCATACAGAAGTCTATCCTAAGAGATGCTCTTAGTGATCTTGCATTACATTTTC
TGAACAAGATGAAGATCATGGTGGTTAAGGATATTGAAAGAGAAGACATTGAATTTATTTGTAA
GACAATTGGAACCAAGCCAGTTGCTCATATTGACCAGTTCACCACTGACATGCTGGGTTCTGCT
GAGTTAGCTGAAGAGGTCAATTTAAATGGTTCTGGCAAACTGCTCAAGATCACAGGCTGTGCAA
GCACTGGAAAAACAGTTACAATTGTTGTTCGTGGCTCTAACAAACTGGTGATTGAAGAAGCTGA
ACGTTCCATTCACGATGCCCTGTGTGTTATTCGCTGCTTAGTGAAGAAGAGAGCTCTTATTGCA
GGAGGTGGCGCTCCAGAAATAGAGTTGGCCCTGAGATTGACTGAGTACTCAAGAACACTGAGTG
GCATGGAATCCTACTGTGTCCGTGCTTTCGCAGATGCTATGGAGGTAATTCCTTCTACACTAGC
TGAGAACGCCGGCCTGAGTCCCATTTCCACAGTAACAGAACTGAGAAACCGGCATGCCCACGGA
GAGAAAACTGCAGGCATTAATGTCCGAAAGGGTGGTATCTCCAACATTTTGGAGGAGATGGTTG
TCCAGCCTTTGTTGGTGTCAGTCAGTGCGCTGACCCTAGCAACTGAAACGGTCCGGAGCATTTT
GAAAATTGATGATGTGGTAAACACTCGATAATCTGAATACAGTGGCTGACTGGCAGCATTATAT
TACCAGTACTGCAATTCAAGTGGAAGAAGATCTTGGTATTCCTAGTTGTTCAAAGGGTTGTTTG
TGCTCTGAATTCCTGGACTTGGTCTTCTGGTTGGCGTTTGCTTGAAATTGTGTTGGAACAACTC
AATATTAAATACCTGATTTCAAAAGAT

hide sequence

Protein Sequences


Protein RefSeqs	XP_005385790	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000020898
	ENSCLAP00000020898.1
	ENSCLAP00000020899.1

RefSeq Acc Id:

XP_005385790 ⟸ XM_005385733

- UniProtKB:

A0A8C2YSW7 (UniProtKB/TrEMBL), A0A8C2VUU3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPENLAPRSGAPAGTAGGRGKSAYQDRDKPAQIRFSNISAAKAVADAIRTSLGPKGMDKMIQDG
KGDVTITNDGATILKQMQVLHPAARMLVELSKAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGI
HPTIISESFQKALEKGLEILTGMSRPVELSDRETLLNSATTSLNSKVVSQYSSLLSPMSVNAVM
RVIDPATATSVDLRDIKIVKKLGGTIDDCELVEGLVLTQKVANSGLTRVEKAKIGLIQFCLSAP
KTDMDNQIVVSDYAQMDRVLREERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLNKM
KIMVVKDIEREDIEFICKTIGTKPVAHIDQFTTDMLGSAELAEEVNLNGSGKLLKITGCASTGK
TVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGMES
YCVRAFADAMEVIPSTLAENAGLSPISTVTELRNRHAHGEKTAGINVRKGGISNILEEMVVQPL
LVSVSALTLATETVRSILKIDDVVNTR

hide sequence

Ensembl Acc Id:

ENSCLAP00000020898 ⟸ ENSCLAT00000021099

Ensembl Acc Id:

ENSCLAP00000020899 ⟸ ENSCLAT00000021100

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000014321	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000021099	ENTREZGENE
	ENSCLAT00000021099.1	UniProtKB/TrEMBL
	ENSCLAT00000021100.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.560.10	UniProtKB/TrEMBL
	3.30.260.10	UniProtKB/TrEMBL
	3.50.7.10	UniProtKB/TrEMBL
InterPro	Chap_CCT_delta	UniProtKB/TrEMBL
	Chaperone_TCP-1	UniProtKB/TrEMBL
	Chaperonin_TCP-1_CS	UniProtKB/TrEMBL
	Cpn60/GroEL/TCP-1	UniProtKB/TrEMBL
	GroEL-like_apical_dom_sf	UniProtKB/TrEMBL
	GROEL-like_equatorial_sf	UniProtKB/TrEMBL
	TCP-1-like_intermed_sf	UniProtKB/TrEMBL
	TCP-1_chaperonin	UniProtKB/TrEMBL
	thermosome_alpha	UniProtKB/TrEMBL
NCBI Gene	Cct4	ENTREZGENE
PANTHER	PTHR11353	UniProtKB/TrEMBL
Pfam	Cpn60_TCP1	UniProtKB/TrEMBL
PRINTS	TCOMPLEXTCP1	UniProtKB/TrEMBL
PROSITE	TCP1_1	UniProtKB/TrEMBL
	TCP1_2	UniProtKB/TrEMBL
	TCP1_3	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48592	UniProtKB/TrEMBL
	SSF52029	UniProtKB/TrEMBL
	SSF54849	UniProtKB/TrEMBL
UniProt	A0A8C2VUU3	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C2YSW7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Cct4	chaperonin containing TCP1 subunit 4		chaperonin containing TCP1, subunit 4 (delta)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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