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Gene: Alk (ALK receptor tyrosine kinase) Chinchilla lanigera

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Symbol:

Alk

Name:

ALK receptor tyrosine kinase

RGD ID:

8705224

Description:

ENCODES a protein that exhibits heparin binding (ortholog); identical protein binding (ortholog); protein tyrosine kinase activity (ortholog); INVOLVED IN adult behavior (ortholog); brain development (ortholog); cell surface receptor protein tyrosine kinase signaling pathway (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); anaplastic large cell lymphoma (ortholog); Brain Neoplasms (ortholog); FOUND IN plasma membrane (ortholog); protein-containing complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

ALK tyrosine kinase receptor; anaplastic lymphoma receptor tyrosine kinase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955469	11,047,048 - 11,548,233 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955469	11,049,373 - 11,751,235 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alcohol dependence (ISO)

anaplastic large cell lymphoma (ISO)

Brain Neoplasms (ISO)

Breast Neoplasms (ISO)

diffuse large B-cell lymphoma (ISO)

diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype (ISO)

Familial Isolated Pituitary Adenoma (ISO)

Granuloma, Plasma Cell (ISO)

Hereditary Neoplastic Syndromes (ISO)

Inflammatory Breast Neoplasms (ISO)

lung adenocarcinoma (ISO)

lung cancer (ISO)

lung non-small cell carcinoma (ISO)

lung squamous cell carcinoma (ISO)

multiple endocrine neoplasia type 2A (ISO)

Neoplasm Metastasis (ISO)

Neoplasm Recurrence, Local (ISO)

Neoplastic Cell Transformation (ISO)

neuroblastoma (ISO)

Neuroblastoma 3 (ISO)

ovarian cancer (ISO)

pulmonary plasma cell granuloma (ISO)

renal cell carcinoma (ISO)

rhabdomyosarcoma (ISO)

tic disorder (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adult behavior (ISO)

brain development (ISO)

cell surface receptor protein tyrosine kinase signaling pathway (ISO)

energy homeostasis (ISO)

hippocampus development (ISO)

negative regulation of lipid catabolic process (ISO)

nervous system development (ISO)

peptidyl-tyrosine autophosphorylation (ISO)

phosphorylation (ISO)

positive regulation of dendrite development (ISO)

protein autophosphorylation (ISO)

regulation of cell population proliferation (ISO)

regulation of dopamine receptor signaling pathway (ISO)

response to environmental enrichment (ISO)

response to stress (ISO)

swimming behavior (ISO)

Cellular Component

plasma membrane (ISO)

protein-containing complex (ISO)

Molecular Function

heparin binding (ISO)

identical protein binding (ISO)

protein binding (ISO)

protein tyrosine kinase activity (ISO)

receptor signaling protein tyrosine kinase activator activity (ISO)

transmembrane receptor protein tyrosine kinase activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Alk
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955469	11,047,048 - 11,548,233 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955469	11,049,373 - 11,751,235 (-)	NCBI	ChiLan1.0	ChiLan1.0

ALK
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	29,192,774 - 29,921,586 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	29,192,774 - 29,921,586 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	29,415,640 - 30,144,452 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	29,269,144 - 29,997,936 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	29,327,292 - 30,056,083	NCBI
Celera	2	29,260,042 - 29,988,141 (-)	NCBI		Celera
Cytogenetic Map	2	p23.2-p23.1	NCBI
HuRef	2	29,156,646 - 29,883,927 (-)	NCBI		HuRef
CHM1_1	2	29,345,879 - 30,074,503 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	29,236,229 - 29,965,553 (-)	NCBI		T2T-CHM13v2.0

Alk
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	72,174,206 - 72,911,719 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	72,175,967 - 72,911,622 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	71,868,988 - 72,604,702 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	71,868,972 - 72,604,627 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	72,218,328 - 72,953,647 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	71,009,971 - 71,745,160 (-)	NCBI		MGSCv36	mm8
MGSCv36	17	71,773,845 - 72,508,684 (-)	NCBI		MGSCv36	mm8
Celera	17	76,136,594 - 76,877,724 (-)	NCBI		Celera
Cytogenetic Map	17	E1.3	NCBI
cM Map	17	43.77	NCBI

Alk
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	28,631,431 - 29,351,321 (+)	NCBI		GRCr8
mRatBN7.2	6	22,879,653 - 23,599,636 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	22,880,625 - 23,598,034 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	23,211,130 - 23,929,220 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	23,526,957 - 24,245,096 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	23,008,575 - 23,732,971 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	22,696,415 - 23,203,791 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	22,696,397 - 23,203,775 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	33,690,337 - 33,703,521 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	6	32,580,744 - 33,082,977 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	23,009,061 - 23,730,939 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	23,700,711 - 23,727,905 (+)	NCBI
Celera	6	22,414,691 - 23,129,629 (+)	NCBI		Celera
Cytogenetic Map	6	q14	NCBI

ALK
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	96,583,820 - 97,316,156 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	96,587,794 - 97,320,129 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	29,196,195 - 29,930,062 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	29,276,041 - 30,007,687 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	29,276,041 - 30,006,735 (-)	Ensembl	panpan1.1		panPan2

ALK
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	23,010,308 - 23,688,841 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	23,010,308 - 23,688,841 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	22,797,195 - 23,482,846 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	23,570,633 - 24,250,513 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	23,572,834 - 24,250,519 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	22,869,939 - 23,549,638 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	22,932,402 - 23,612,861 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	23,038,591 - 23,719,569 (-)	NCBI		UU_Cfam_GSD_1.0

Alk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	67,167,996 - 67,810,992 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936493	3,028,608 - 3,671,874 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936493	3,624,288 - 3,671,567 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ALK
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	3	109,411,146 - 110,105,755 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	116,847,214 - 116,923,998 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ALK
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	77,632,809 - 78,408,307 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666045	33,719,552 - 34,471,342 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Alk
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	11,095,134 - 11,288,891 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624738	11,094,699 - 12,010,349 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005400546	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01052554	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01052555	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01052556	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01052557	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01052558	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01052559	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01052560	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01052561	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01052562	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01052563	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01052564	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01052565	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01052566	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCQ01044578	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000011461 ⟹ ENSCLAP00000011324

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955469	11,047,048 - 11,548,233 (-)	Ensembl

Ensembl Acc Id:

ENSCLAT00000011462 ⟹ ENSCLAP00000011325

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955469	11,047,048 - 11,548,233 (-)	Ensembl

Ensembl Acc Id:

ENSCLAT00000011463 ⟹ ENSCLAP00000011326

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955469	11,050,671 - 11,243,097 (-)	Ensembl

RefSeq Acc Id:

XM_005400546 ⟹ XP_005400603

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955469	11,049,373 - 11,751,235 (-)	NCBI

Sequence:

show sequence

CAGCGGCTCCCCGGGCGGCAGCGGCGGTAGCAGCTGGCAACCTCCTCTGCCGCTATCCCGGGGG
TCTCGGGGCACCGAGACATCTTCGCACCGCCTTCTGGCCAACAACCCGAAGCCACCCGCGCAGA
GATAGGTGAGGAGAGGGCAAGATTCCGGCTTCCCTGCCCTGAATGCTTTCACTCCGCCGCTGCC
GCCGGGGCGGCCCTGACGCCTGCGAGAGAACTCCTAGGAGCCCAGACGCGGGCGACCGCAAGGA
CGCTGCAAACTTGCGCGCCGGCGGCTGCCAGAGCGGAGGCTGTCAGAGCCTCCGCTCCGCAGGA
CCGGGGCTCGCATTCACGCCCAGAAGTTCAGAGGGCAGTGCAGTCCCAAGACTTCCTGCAGAGG
AGGGCGCTTGAGGGGGCGCTAGAAAGCAAGCCCCTCCCGCGATTCTAGCTCCAGACCCGGGGAG
AGGAGATCAGAGGAGCCGAAAGCAACCGCGGGAGGTGGCCAGGGCAGGGGGCACCTGCTTAGAG
CCACGGCTCCCAGCCTGGAAAGTTGCGGAGGATTGGAGACGGCCCGGAGAACCGACAGACCCTA
GCTCTGGCCGCGGGGGGCAGGAGGGGACGGCACCCAATTGCCACCTCCTTTTTAGCATAGTAGT
TTCTCGTTCGCCAGCGCAGCGAGCTACAAACGGGGGCGCGGCACTCGGCAGGGCGAGCTAGAGG
CACAGGGTCCAGCTGTTGAGCCCAGAGAGCTTCAGGGTCTCTGGACTCACGCCTGGCTTGCAGC
TCCGTCTCATTCAGACCGCAGCTAGGGTAAATCTAGGGAATCAAGTGCACGCGCGGTGCCCCAG
AGACAGGTGGAAGGAGCCCTTCAGGACCAAGGACCGTTTGGAGCCCCTTCCTGTTTGGGGGAAA
GCTAAGGGCGAGGCTGGGCCCGGGAGAGTTGGAGATTAGTACCGACAGCCCTCTCCTTGCGGGA
TGGCAGCCTTCGGGCTCCTGTGGCTCCTGCCACTACTGTCAGCAATAGCCTCGGGCTCCGCGGT
CGCGCCTGGCCATCGCGCGGGGTCACCGGTCATAGGGCCGCCTCTGCAGCCCCGGGAGCCGCTC
AGCTACTCGCGCCTGCAGAGGAAGAGTCTGGCGGTAGACTTCGTGGTGCCCTCGCTCTTCCGCG
TCTACGCCCGCGACCTGCTGCTGCCGCCGCCATCCCTTTCGGAGCCGAGGGCCGGCCGGCCAGA
GGCGCGTGGCTGGCTGGCCCTCGACTGCGCACCGCTGCTCAGGCTGCTGGGGCCGCCCCCTGGG
GTCTCCTGGACAGCAGGCGACACTTCGCCGTCTCCTGGCACAGTACCGACGCTGTCCAGGGTGC
TGAAGGGCGGCTCGGTGCGCAAGCTCCGGCGCGCCAAGCAGCTGGTGCTGGAGCTGGGCGAGGA
GGCGATCCTTGAGGGCTGCGTTGGGCCCCCAGAGGAGGCAGCTGTGGGACTGCTCCAGTTCAAC
CTCACCGAGCTGTTCAGCTGGTGGATTCGCCACGGCGAAGGACGGCTGAGAATCCGCCTGATGC
CCGAGAAGAAGGCATCGGAAGTGGGGAGAGAGGGAAGGCTGTCCGCCGCAATCCGCGCCTCTCA
GCCCCGCCTTCTCTTCCAGATCTACGGGACCGGTCATAGCACCTTGGAGCTACCAACAAACATG
CCTACTCCTCCTGATTATTTTTTGTGGAATCTGACCTGGATAATGAAAGATTCCTTCCCTTTCC
TGTCTCATCGCAGCCGGTATGGTTTGGAGTGCAGCTTTGACTTCCCTTGTGAGCTGGAATATTC
TCCTCCACTGCATGACCTTGGGAACCAGAGCTGGTCCTGGCGCCGTGTACCCTCTGAGGAGGCC
TCCCAGATGGATTTGTTGGATGGACCTGAAGCAGAACGTTCTAAAGAGATGCCCAGAGGCTCCT
TCCTCCTCCTGAACACCTCAGCGGACTCGAAACACACCATTCTCAGCCCGTGGATGAGGAGCAG
TAGTGAGTACTGTACACTGGCTGTCTCTGTGCACAGGCACCTGCAGCCCTCTGGGAGGTACATC
GCCCAGCTGCTACCCCACAATGAGGCTGGAAGAGAGATTCTCCTGGTACCCACGCCAGGGAAGC
ATGGCTGGACGGTACTGCAAGGAAGAATCGGGCGCCCAGAGAACCCCTTCCGAGTGGCCCTGGA
ATATATCTCCAGTGGAAACCGAAGCCTGTCTGCAGTGGACTTCTTTGCCCTGAAGAACTGCAGT
GAAGGAACATCCCCAGGCTCCAAGATGGCCCTGCAGAGTTCCTTCACTTGTTGGAATGGGACAG
TCCTCCAGCTCGGGCAGGCCTGCGACTTCCACCGGGACTGCGCCCAGGGAGAAGACGAGGGCCA
GCTGTGCAGTCAACTTCCTGCTAGTTTTTACTGCAACTTTGAGGACGGTTTCTGTGGCTGGACC
GAAGGCACCTTCTCACCCCATGTGCCCCGGTGGCAAGTCAGGACCCTGAAGGATGCCTGGTCCC
AGGACCACCAAGACCATGCCCTGTCGCTCAGTACCACTGATGTCCCCGGTCCTGAAAGTGCAAC
AGTTACCAGTGCTACATTTCCTGCACCGATGAAGAACTCTCCATGTGAGCTCAGAATGTCCTGG
CTCATCCGTGGAGTCTTAAGAGGAAATGTGTCCTTGGTGCTGGTGGAAAACAAAACCGGGAAGG
AGCAAAGCAGAATGATCTGGCATGTGGCCACCAATGAAGGCTTGAGCTTGTGGCAGTGGGCAGT
GCTTCCTCTCCTCAATGTGTCCGACAGGTTCTGGCTGCAGATGGTCGCGTGGTGGGGGCAAGGA
TCCAGAGCCACCGTGGCTTTTGACAATATCTCCATCAGTCTGGACTGCTACCTCACCATCGGTG
GGGAGGACAAGATGCCCCAGAGTGAAGAACCCAAATCAAGAAATCTATTTGAGAGGAACACAAA
CAAGGAGCCCAAATCCTTGGACAGCAGACCAAGGCATTTGCCTGTCTTCAACCCTACAGTTCAC
TGGCTGTTCACCACATGTGGGGCGAGCGGGCCCCATGGCCCCACTCAGACCCAGTGCAACAATG
CCTACCAGAACTCCAACCTGAGTGTGATAGTGGGGAGCGAAGGGCCCTTGAAGGGCGTCCAGAT
CTGGAAAGTGCCAGCCACCGACACCTACAGCATCTCATGCTACGGTGCCGCCGGCGGGAAAGGC
GGGAAGAACACCATGATACGGTCGCATGGCGTGTCTGTGCTGGGCATCTTCAACCTGGAGAAGG
ACGACATGCTATACATCCTCGTCGGGCAGCAGGGAGAAGACGCCTGCCCCAGTACAAACCAATT
AATCCAGAAAGTCTGCATTGGAGAGAGCAACGTGATAGAAGAAGAAATTCGTGTGAACAGAAGT
GTGCATGAGTGGGCAGGAGGAGGAGGAGGTGGGGGTGGAGCCACCTACGTGTTTAAGATGAAGG
ATGGAGTGCCCGTGCCCCTCATCATTGCAGCTGGCGGTGGCGGCAGGGCCTACGGGGCCAAGAC
AGACACGTTCCACTCGGAGAGACTGGAGAATAACTCCTTGGTTCTAGGGCTGAACGGCAATTCC
GGAGCCGCAGGTGGTGGAGGTGGCTGGGATGATAACACTTCCTTACTCTGGGCCGGAAAATCTT
TGTTGGAGGGCGCTACTGGAGGACATGCCTGCCCCCAGGCCATGAAGAAGTGGGGGTGGGAGAC
AAGAGGGGGTTTCGGAGGGGGTGGCGGGGGGTGCTCCTCAGGTGGAGGAGGCGGAGGATATATA
GGTGGCAATGCAGCCTCAAACAATGACCCTGAAATTGATGGGGAAGATGGGGTTTCCTTCATCA
GTCCCCTGGGCATCCTGTACACCCCCGCTTTAAAAGTGATGGAGGGCCATGGGGAAGTGAATAT
TAAGCATTACCTAAACTGCAGTCACTGTGAGGTGGATGAATGTCACCTGGACCCTCAGAGCCAC
AAGATCATCTGCTTCTGTGACCATGGGACAGTGCTGGCTGAGGACGGCGTCTCCTGCATTGTGT
CGCCCACACCAGAACCCCACCTGCCTCTCTCGCTGATCCTCTCTGTGGTGACCTCTGCTCTGGT
GGCTGCCCTTGTCCTGGCTTTCTCTGGCATCATGATAGTGTACCGCCGGAAGCACCAGGAGCTG
CAAGCCATGCAGATGGAGCTGCAGAGCCCTGAGTATAAGCTCAGCAAGCTCCGCACCTCCACCA
TCATGACAGACTACAACCCTAACTACTCCTTTGCTGGCAAGACTTCCTCCATCAGCGACCTAAA
AGAGGTGCCACGGAAAAACATCACCCTCATTCGGGGTCTGGGCCATGGTGCATTTGGGGAGGTG
TATGAAGGCCAGGTGTCTGGGATGCCCAACGATCCGAGCCCCCTGCAAGTGGCTGTGAAGACGC
TGCCGGAAGTGTGCTCAGAACAGGACGAACTAGACTTCCTCATGGAAGCTCTGATCATCAGCAA
ATTCAACCACCAGAACATTGTGCGCTGCATCGGGGTGAGCCTGCAAGCCCTGCCCCGCTTCATC
CTGCTGGAGCTCATGACAGGAGGAGACCTCAAGTCCTTCCTCCGGGAGACGCGGCCTCGCCCAA
GTCAGCCCTCCTCCCTGGCCATGCTGGACCTTCTGCATGTGGCTCGGGACATTGCCTGTGGCTG
TCAGTATCTAGAGGAAAACCACTTCATCCACCGGGACATTGCTGCCAGGAACTGCCTCTTGACC
TGTCCTGGCAGTGGAAGAATAGCAAAGATTGGAGACTTTGGGATGGCCCGAGACATCTACAGAG
CCAGCTACTACAGAAAGGGAGGCTGTGCCATGCTCCCCGTCAAATGGATGCCTCCCGAGGCCTT
CATGGAAGGAATATTCACTTCTAAGACAGATACATGGTCCTTTGGCGTGCTGCTATGGGAGATC
TTCTCTCTGGGTTACATGCCGTACCCCAGCAAAAGCAATCAGGAGGTTCTGGAGTTCGTCACCA
GTGGAGGACGGATGGACCCACCTAAGAACTGCCCCGGGCCTGTGTACCGGATAATGACCCAGTG
CTGGCAACACCAGCCTGAAGACAGGCCAAATTTTGCCATAATTTTGGAGAGGATTGAATACTGC
ACACAGGACCCAGACGTCATCAACACCGCTCTGCCCATAGAGTACGGCCCACCTATGGAGGAGG
AGGAGAAAGTGCCCGTGCGGCCCAAAGACCCCGAGGGGATGCCGCCCCTGCTGGTGTCTCCCCA
GCAGGCTAAACCGGAGGTGGAACGTGTCCCGGCCCCAGCTGTGCCACTAGCCCTGCCCACCGCG
GCCTCCTCCGGCAAGGCTGTGAAGAAGCCCGCAGCGGGGGTCTCGGTGCAGGTCCCGCGGGGGC
CGGCCGTGGAAGGGGGACACATTAACATGGCATTCTCTCAGTCCAACCCGCCGCCCGCGCTGCA
CAGGGTCCAGGGATCCAGAAACAAGCCGACCAACTTGTGGAACCCGACTTACGGCTCATGGTTT
ACAGAGAAACCTGCCAAAAAGAACAATCCTCCAGCAAACAAGGAGCCGCACCAGAAGGGCAGCG
CGGGCCGCGAGGGAAGCTGTACTGTCCCGCCCAGCGCGGCCGCCGGCAGACTGCCCGGGGCCTC
CCTGCTGCTGGAGCCCTCTTCGCTGACTGCCAGCGTGAAGGAGGTGCCTCTGTTCCGGCTGCGT
CACTTCCCCTGTGGGAATGTCAACTACGGCTACCAGCAGCAGGGCTTACCTTTAGAGGCCACCA
CTGCCCCTGGAGCTGGTCATTACGAGGACACCACTCTGAAGAACAAGAGCAGCGCCGGCCAGCC
TGGGCCCTGAACTCCACGCTGGCTCAGTTCTCTCGGAGAGAGCCCAAGCCCACAGAGGAGGGGG
CCGGGGCTCCACCACCAGAGACCAAACGTCACTTTCATGTTGTGCCAACTTGTTTTGAAGTGCC
ACATACAATGCTGTACATTCAAAATGCTTTAGAGAGGTTTTGAGCATGGGTTCACCTTATTCTT
TCAAAAGAAGAACGTACCCTACAAACAAGGGATCAATACACGGCCCGACTGGTGGCATAAGGTT
TTACGCATGGTTGTGGTCGACTTCCTTATGCTTCTTTTAAACTGCGTGTGCTCTGCTTCAGTGT
AGTAAGAACTAGCTGCTTATGTGTCTCATAGTGGAAGTCATCGTTTCCTTACCTTGCTGATGTG
GACGTGAACAATTTGAGGGGTGAGGAAATGGCAATAAAGACGTGCATTGTAATGACTAGCATGG
AGAAAGACATTCTTTACTTAGAAAAGAAAAATCATAAACTACTGAGTGAAACATCACTTTAGAT
GGGTAGATGCTTCTAATTGTACTGATTCATTGCCAATTGTAAAAAAAAAAAATGTCATGAGTGG
TTCCATAGTATAGAGAAAATGTACATACTGTATACTCACATAAATGGAATACATACATCCCAAG
TGCTTTGAGTAGGATAAAAACTAGTATAGACCCAGAATTCACCAACCCTATTAATATACCTCAT
GCCTTAAGAAAATCCCTCTACTAATAGTGAAAAACTGAGTGTGAGGTTTCCTGCTGAATTTAAA
ACTCAAGACTTAAATTACTTTCAAACTTTCCACTAATTCACATCTGATAGTTAGAAACAAAAAT
TCTAAGCAGCAGTAATACATCAGAGCATAGAAACATATCCATCTGTGGGCACATGTATCGATAT
ATCTTAAGCCAAAATTTTCTGACAGTTTCAGTCATGAACCCCACCAAATTAAGTTCCTCCTCTC
AGTGACAGACAGGGTCACAGGAGGAACAGCCCTTCAGGAGTCCTAGGAAAGTACTAACGCAGTA
TCCTTCGTTCTCCTGTCCACTTGTGTTTTCTCTCCCTCATGTGATCCTGGTACACTGGGAACAC
AAATATGATGAAATAATCATAGCGTCATTGCTGCAGCAACAAATTTACATTAAACAAAAGATTT
TCCCCTAGGCAGCAATGAAGAAAGAGGTTTAGGAGTGCTTGGAGAGTTGGGGTTCACGCTGACA
TGTGACAGAGGGGGTTCTGAACCTGGTTTTCACGGATGAAATTTATTTCTATGAAACTGAACTG
GGAACCCATTAAATTGTACATGCACCAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005400603	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000011324
	ENSCLAP00000011324.1
	ENSCLAP00000011325.1
	ENSCLAP00000011326.1

RefSeq Acc Id:

XP_005400603 ⟸ XM_005400546

- UniProtKB:

A0A8C2VCC7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAFGLLWLLPLLSAIASGSAVAPGHRAGSPVIGPPLQPREPLSYSRLQRKSLAVDFVVPSLFR
VYARDLLLPPPSLSEPRAGRPEARGWLALDCAPLLRLLGPPPGVSWTAGDTSPSPGTVPTLSRV
LKGGSVRKLRRAKQLVLELGEEAILEGCVGPPEEAAVGLLQFNLTELFSWWIRHGEGRLRIRLM
PEKKASEVGREGRLSAAIRASQPRLLFQIYGTGHSTLELPTNMPTPPDYFLWNLTWIMKDSFPF
LSHRSRYGLECSFDFPCELEYSPPLHDLGNQSWSWRRVPSEEASQMDLLDGPEAERSKEMPRGS
FLLLNTSADSKHTILSPWMRSSSEYCTLAVSVHRHLQPSGRYIAQLLPHNEAGREILLVPTPGK
HGWTVLQGRIGRPENPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGT
VLQLGQACDFHRDCAQGEDEGQLCSQLPASFYCNFEDGFCGWTEGTFSPHVPRWQVRTLKDAWS
QDHQDHALSLSTTDVPGPESATVTSATFPAPMKNSPCELRMSWLIRGVLRGNVSLVLVENKTGK
EQSRMIWHVATNEGLSLWQWAVLPLLNVSDRFWLQMVAWWGQGSRATVAFDNISISLDCYLTIG
GEDKMPQSEEPKSRNLFERNTNKEPKSLDSRPRHLPVFNPTVHWLFTTCGASGPHGPTQTQCNN
AYQNSNLSVIVGSEGPLKGVQIWKVPATDTYSISCYGAAGGKGGKNTMIRSHGVSVLGIFNLEK
DDMLYILVGQQGEDACPSTNQLIQKVCIGESNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMK
DGVPVPLIIAAGGGGRAYGAKTDTFHSERLENNSLVLGLNGNSGAAGGGGGWDDNTSLLWAGKS
LLEGATGGHACPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEIDGEDGVSFI
SPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHLDPQSHKIICFCDHGTVLAEDGVSCIV
SPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTST
IMTDYNPNYSFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKT
LPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQALPRFILLELMTGGDLKSFLRETRPRP
SQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGSGRIAKIGDFGMARDIYR
ASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVT
SGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPPMEE
EEKVPVRPKDPEGMPPLLVSPQQAKPEVERVPAPAVPLALPTAASSGKAVKKPAAGVSVQVPRG
PAVEGGHINMAFSQSNPPPALHRVQGSRNKPTNLWNPTYGSWFTEKPAKKNNPPANKEPHQKGS
AGREGSCTVPPSAAAGRLPGASLLLEPSSLTASVKEVPLFRLRHFPCGNVNYGYQQQGLPLEAT
TAPGAGHYEDTTLKNKSSAGQPGP

hide sequence

Ensembl Acc Id:

ENSCLAP00000011326 ⟸ ENSCLAT00000011463

Ensembl Acc Id:

ENSCLAP00000011325 ⟸ ENSCLAT00000011462

Ensembl Acc Id:

ENSCLAP00000011324 ⟸ ENSCLAT00000011461

Protein Domains

MAM Protein kinase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000007813	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000011461	ENTREZGENE
	ENSCLAT00000011461.1	UniProtKB/TrEMBL
	ENSCLAT00000011462.1	UniProtKB/TrEMBL
	ENSCLAT00000011463.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.120.200	UniProtKB/TrEMBL
	4.10.400.10	UniProtKB/TrEMBL
	Phosphorylase Kinase, domain 1	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	ALK/LTK-like_GRD	UniProtKB/TrEMBL
	ConA-like_dom_sf	UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/TrEMBL
	LDL_receptor-like_sf	UniProtKB/TrEMBL
	LDrepeatLR_classA_rpt	UniProtKB/TrEMBL
	MAM_dom	UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	RTK	UniProtKB/TrEMBL
	Ser-Thr/Tyr_kinase_cat_dom	UniProtKB/TrEMBL
	Tyr_kinase_AS	UniProtKB/TrEMBL
	Tyr_kinase_cat_dom	UniProtKB/TrEMBL
	Tyr_kinase_rcpt_2_CS	UniProtKB/TrEMBL
NCBI Gene	Alk	ENTREZGENE
PANTHER	PTHR24416:SF276	UniProtKB/TrEMBL
	TYROSINE-PROTEIN KINASE RECEPTOR	UniProtKB/TrEMBL
Pfam	Gly_rich	UniProtKB/TrEMBL
	MAM	UniProtKB/TrEMBL
	PK_Tyr_Ser-Thr	UniProtKB/TrEMBL
PRINTS	TYRKINASE	UniProtKB/TrEMBL
PROSITE	MAM_2	UniProtKB/TrEMBL
	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_TYR	UniProtKB/TrEMBL
	RECEPTOR_TYR_KIN_II	UniProtKB/TrEMBL
SMART	LDLa	UniProtKB/TrEMBL
	TyrKc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF49899	UniProtKB/TrEMBL
	SSF56112	UniProtKB/TrEMBL
	SSF57424	UniProtKB/TrEMBL
UniProt	A0A8C2V793_CHILA	UniProtKB/TrEMBL
	A0A8C2V795_CHILA	UniProtKB/TrEMBL
	A0A8C2VCC7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-03-08	Alk	ALK receptor tyrosine kinase		anaplastic lymphoma receptor tyrosine kinase	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

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Imported Disease Annotations - OMIM