Mettl21a (methyltransferase 21A, HSPA lysine)

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Gene: Mettl21a (methyltransferase 21A, HSPA lysine) Rattus norvegicus

Analyze

Symbol:

Mettl21a

Name:

methyltransferase 21A, HSPA lysine (Ensembl:methyltransferase like 21A)

RGD ID:

7651604

Description:

Predicted to enable ATPase binding activity; Hsp70 protein binding activity; and protein-lysine N-methyltransferase activity. Predicted to be involved in peptidyl-lysine methylation. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Orthologous to human METTL21A (methyltransferase 21A, HSPA lysine); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A; gentamycin.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Fam119a; family with sequence similarity 119, member A; LOC102553119; methyltransferase like 21A; protein N-lysine methyltransferase METTL21A-like; RGD1311824

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	METTL21A (methyltransferase 21A, HSPA lysine)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, PhylomeDB, Treefam
Mus musculus (house mouse):	Mettl21a (methyltransferase 21A, HSPA lysine)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mettl21a (methyltransferase 21A, HSPA lysine)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	METTL21A (methyltransferase 21A, HSPA lysine)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	METTL21A (methyltransferase 21A, HSPA lysine)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mettl21a (methyltransferase 21A, HSPA lysine)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	METTL21A (methyltransferase 21A, HSPA lysine)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	METTL21A (methyltransferase 21A, HSPA lysine)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mettl21a (methyltransferase 21A, HSPA lysine)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CLPB (ClpB family mitochondrial disaggregase)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Mettl21a (methyltransferase 21A, HSPA lysine)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	METTL21A (methyltransferase 21A, HSPA lysine)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mettl21a (methyltransferase like 21A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	EFM6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C42C1.13	Alliance	DIOPT (InParanoid\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mettl21a	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	9	65,934,253 - 65,999,964 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	65,978,051 - 65,987,550 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	74,497,956 - 74,507,394 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	9	79,628,726 - 79,638,210 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	9	78,033,180 - 78,042,666 (-)	NCBI	Rnor_WKY
Rnor_6.0	9	71,304,138 - 71,314,015 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	71,304,427 - 71,313,940 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	71,262,537 - 71,272,027 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	9	63,384,809 - 63,394,665 (-)	NCBI		Celera
Cytogenetic Map	9	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Neurodevelopmental Disorders (ISO)

primary pulmonary hypertension (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

avobenzone (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-carotene (ISO)

bisphenol A (EXP,ISO)

bortezomib (ISO)

butanal (ISO)

caffeine (ISO)

clofibrate (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

dexamethasone (ISO)

dibutyl phthalate (ISO)

dorsomorphin (ISO)

entinostat (ISO)

ethyl methanesulfonate (ISO)

folic acid (ISO)

gentamycin (EXP)

hydrogen peroxide (ISO)

hydroquinone (ISO)

indometacin (ISO)

panobinostat (ISO)

paracetamol (EXP,ISO)

phenylmercury acetate (ISO)

quercetin (ISO)

SB 431542 (ISO)

senecionine (ISO)

silicon dioxide (ISO)

temozolomide (ISO)

thioacetamide (EXP)

trichostatin A (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

peptidyl-lysine methylation (IBA,ISO)

protein methylation (ISO)

regulation of ATP-dependent activity (ISO)

Cellular Component

cytoplasm (IBA)

cytosol (IBA)

protein-containing complex (ISO)

Molecular Function

ATPase binding (ISO)

heat shock protein binding (ISO)

Hsp70 protein binding (ISO)

protein binding (ISO)

protein methyltransferase activity (ISO)

protein-lysine N-methyltransferase activity (IBA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:22948820	PMID:23349634	PMID:23921388

Genomics

Comparative Map Data

Mettl21a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	9	65,934,253 - 65,999,964 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	65,978,051 - 65,987,550 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	74,497,956 - 74,507,394 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	9	79,628,726 - 79,638,210 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	9	78,033,180 - 78,042,666 (-)	NCBI	Rnor_WKY
Rnor_6.0	9	71,304,138 - 71,314,015 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	71,304,427 - 71,313,940 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	71,262,537 - 71,272,027 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	9	63,384,809 - 63,394,665 (-)	NCBI		Celera
Cytogenetic Map	9	q32	NCBI

METTL21A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	207,580,635 - 207,626,053 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	2	207,580,631 - 207,625,928 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	208,445,359 - 208,490,777 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	208,185,071 - 208,197,953 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	2	202,237,420 - 202,251,254 (-)	NCBI		Celera
Cytogenetic Map	2	q33.3	NCBI
HuRef	2	200,316,943 - 200,331,976 (-)	NCBI		HuRef
CHM1_1	2	208,479,659 - 208,495,798 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	208,054,650 - 208,100,120 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	76,470,923 - 76,472,979 (-)	NCBI

Mettl21a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	64,645,632 - 64,661,926 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	64,645,632 - 64,656,401 (-)	Ensembl		GRCm39 Ensembl
GRCm38	1	64,606,473 - 64,620,466 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	64,606,473 - 64,617,242 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	64,653,054 - 64,663,742 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	64,540,756 - 64,551,444 (-)	NCBI		MGSCv36	mm8
Celera	1	65,107,887 - 65,118,599 (-)	NCBI		Celera
Cytogenetic Map	1	C2	NCBI

Mettl21a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955457	7,411,218 - 7,421,832 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955457	7,411,218 - 7,421,832 (+)	NCBI	ChiLan1.0	ChiLan1.0

METTL21A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	2B	110,203,149 - 110,245,150 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	94,814,225 - 94,856,558 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	212,941,308 - 212,983,823 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	212,969,269 - 212,983,177 (-)	Ensembl	panpan1.1		panPan2

METTL21A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	37	15,935,256 - 16,002,089 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	37	15,990,763 - 16,002,256 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	37	16,819,122 - 16,887,414 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	37	15,870,812 - 15,938,784 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	37	15,871,304 - 15,937,716 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	37	15,816,578 - 15,882,999 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	37	15,789,688 - 15,857,867 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	37	15,798,900 - 15,867,034 (-)	NCBI		UU_Cfam_GSD_1.0

Mettl21a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	164,154,512 - 164,169,808 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936631	3,788,754 - 3,804,844 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936631	3,789,577 - 3,804,747 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

METTL21A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	110,763,382 - 110,789,466 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	110,777,577 - 110,789,466 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	122,362,833 - 122,374,726 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

METTL21A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	93,400,602 - 93,416,630 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	93,398,111 - 93,416,535 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	105,959,260 - 106,005,610 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mettl21a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624765	8,354,692 - 8,367,200 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624765	8,354,693 - 8,421,768 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Mettl21a
222 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	3
Count of miRNA genes:	3
Interacting mature miRNAs:	3
Transcripts:	ENSRNOT00000019670
Prediction methods:	Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10054125	Srcrt7	Stress Responsive Cort QTL 7	3.33	0.0011	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	9	1	87073594	Rat
1331757	Cdexp1	CD45RC expression in CD8 T cells QTL 1	4.3		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	9	1024537	67509080	Rat
70186	Niddm26	Non-insulin dependent diabetes mellitus QTL 26	3.87		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	9	22071169	86369743	Rat
631643	Bp120	Blood pressure QTL 120	3	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	22071200	67071200	Rat
7207814	Bmd91	Bone mineral density QTL 91	3.5		femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	9	23754144	83851531	Rat
70218	Cm28	Cardiac mass QTL 28	8.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	25268044	79271759	Rat
724544	Uae9	Urinary albumin excretion QTL 9	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	9	25268044	114175309	Rat
731164	Uae25	Urinary albumin excretion QTL 25	3.5	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	25661188	100929786	Rat
1641894	Alcrsp12	Alcohol response QTL 12			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	27468639	72468639	Rat
7411656	Foco26	Food consumption QTL 26	9.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	32535505	77535505	Rat
7411571	Bw138	Body weight QTL 138	14.3	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	9	32535505	77535505	Rat
1598834	Memor11	Memory QTL 11	2.5		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	9	36962359	77814038	Rat
8662828	Vetf6	Vascular elastic tissue fragility QTL 6	3.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	9	36962359	92058970	Rat
2290450	Scl57	Serum cholesterol level QTL 57	4.15		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	9	36962359	95410867	Rat
6903941	Pur31	Proteinuria QTL 31		0.036	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	9	40194188	85194188	Rat
11353949	Bp393	Blood pressure QTL 393			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	40194188	85194188	Rat
61352	Bp34	Blood pressure QTL 34	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	42495343	79271511	Rat
10058949	Gmadr5	Adrenal mass QTL 5	2	0.014	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	9	42791513	87976209	Rat
11353951	Bp394	Blood pressure QTL 394			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	44649921	89649921	Rat
12879506	Pur33	Proteinuria QTL 33			urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	44649921	89649921	Rat
11353957	Bmd92	Bone mineral density QTL 92		0.01	tibia mineral mass (VT:1000283)	volumetric bone mineral density (CMO:0001553)	9	46114199	91114199	Rat
631656	Bp108	Blood pressure QTL 108	5.97	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	48598251	93598251	Rat
1598849	Memor17	Memory QTL 17	2.2		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	9	49968546	71098346	Rat
2303170	Bp332	Blood pressure QTL 332	3.73	0.027	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	55847841	77026453	Rat
2303180	Bp333	Blood pressure QTL 333		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	56627713	78595166	Rat
2303180	Bp333	Blood pressure QTL 333		0.001	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	9	56627713	78595166	Rat
2303180	Bp333	Blood pressure QTL 333		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	56627713	78595166	Rat
1578760	Cm53	Cardiac mass QTL 53	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	56771635	101771635	Rat
724515	Uae16	Urinary albumin excretion QTL 16	8		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	58163035	100929646	Rat
1300134	Bp185	Blood pressure QTL 185	3.73		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	61381434	104821652	Rat
1581580	Uae34	Urinary albumin excretion QTL 34			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	62072275	96470995	Rat
1578757	Pur6	Proteinuria QTL 6	3.3	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	62072275	96470995	Rat
61385	Edpm9	Estrogen-dependent pituitary mass QTL 9	3.43	0.05	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	9	63869687	108869687	Rat
731171	Glom6	Glomerulus QTL 6	2.8	0.0003	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	9	64573531	109573531	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			4	4		4			43	14	36
Low	3	43	53	37	19	37	8	11	31	21	5	11	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001399451	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006226849	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006226850	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006245082	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006245083	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039084579	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039084580	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039084581	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039084582	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC111319	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ230736	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000214	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000019670 ⟹ ENSRNOP00000019670

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	65,978,051 - 65,987,550 (-)	Ensembl
Rnor_6.0 Ensembl	9	71,304,427 - 71,313,940 (-)	Ensembl

RefSeq Acc Id:

XM_006245082 ⟹ XP_006245144

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	9	65,978,036 - 65,987,090 (-)	NCBI
Rnor_6.0	9	71,304,138 - 71,313,524 (-)	NCBI
Rnor_5.0	9	71,262,537 - 71,272,027 (+)	NCBI

Sequence:

show sequence

CGCTTGCGCGGCGCGCGTAACCTCTCGGAACCGTGAGCATCCATATTGGTGGCGCCGCTGGCTG
GCCTGCGGGCTGTGTCGGCTCCGAGCGTCCACCCGAGGGTCCCCAAGGAGTCCCTGCGGAGTCC
TGCTTCCACCTGCTCCGGGTTCTCGGGACTCTTTCGTGGGCATCAGGAAAGCACGCACCGAGGT
CTCAGCAGAGTTAGAAGAAATGGCCCTGGTACCGTATGAGGAGAGCATGTCAATAGGGCTCCAG
AAACTCCATAAGCCTCTTGCCACCTTCTCGTTTGCAAACCACACCATCCAGATCCGTCAGGACT
GGGGGCGACTGGGAGTGGCTGCAGTGGTTTGGGATGCGGCCATTGTTCTTTCCACGTATCTGGA
GATGGGTGCCGTGGAGCTCAGGGGCTGCTCTGCCGTGGAGCTGGGAGCTGGCACAGGGCTGGTG
GGCATCGTGGCTGCGCTGCTGGGTGCTCATGTGACTATCACGGACCGAAAAGTAGCGTTAGAAT
TTCTTAAGTCAAATGTTGAGGCCAACTTACCTCCCCATATCCAACCTAAGGTGGTTGTTAAGGA
GCTGACTTGGGGACAAAATTTGGACAGTTTTTCACCTGGAGAATTTGATCTCATACTTGGAGCT
GATATCATATACTTAGAAGATACCTTCACAGACCTTCTTCAAACACTGGGACATCTCTGTAGCA
ACAACTCTGTGATTCTTCTAGCTTGCCGAATCCGCTATGAACGGGATAATAACTTCTTAACAAT
GCTGGAGAGGCAGTTCACTGTGAGTAAGGTTCACTACGATCCTGAGAAGGATGTACACATTTAC
AAAGCACAGAAGAGAAAGCAGAGGGAGGACTTGTAGTGGGCAGTATTTTCTAAGAATCGAATGC
ATCAGTTAAGGTCTTACAGCTAGAACTCTTAGCGGTGTTAATGACGTAGCAGACTGCAAGTCAT
TCCTCTCAGAGCTGCTCAAGGAACAAAGCACGTGTGTACTTTGTAGACAATGCCTTGCCTCATT
GCCGGAACTGTCAGTCAGATTGACTGTAGATGGACATGTGAAGTTTGGCTGGTGTTCTTTGCTT
TGCCCTGTGTGCTCACTTGGTAAGCAATTTCCACTGATAAAGAATGATATGAAGGTGTCCCTAA
ACTGGTGAGTCAGTCATATATTCTGGGATGTATTTTGTCTTAGTTTCCTTGTCTGTTGAGTGTA
AACAGACTTATTATATGTCTTCCCTGAAATGTTTGTACTGTTGCAGTCTCTTTTGTGTGTGTGT
GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTAGATAAAGCCTTACTCTGTAGCCCTGG
GTTGGTCTGAAACTGTAGACCAGGCTGACCTCAAGCTTGAAGTAATTCTCTTTCCTCCGCCTCC
GAGTGCTGGGATTACCAGCGTGTGCCATGCCACCTGGCTATTTGGTTCTTAAGCACCTTGAGTT
GAAGATGAGTTTTCTGGCTCTCATATCATACCTTCTTACCAGATTTCAGGGTTAAGTATATAAG
CAAAGAAATAATAAAAATAAAAGTTTACATTTGAAATTA

hide sequence

RefSeq Acc Id:

XM_006245083 ⟹ XP_006245145

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	9	65,978,036 - 65,987,987 (-)	NCBI
Rnor_6.0	9	71,304,138 - 71,314,015 (-)	NCBI
Rnor_5.0	9	71,262,537 - 71,272,027 (+)	NCBI

Sequence:

show sequence

GAAAGGTGGCCGCTTCCGCCGGCTGGGTGTGGGCGTGGAGCGACGCGAGCGCCGGAGTCGGCTG
CACGTGGTTCGGTTCAAAACCCGGCCTGGGCGCCGCACGTCTACTCCCCACCCGCGCCTTGGTT
AGAGATGCTCAGTGGTGATTTTCCCACTTCATGGCCACCGAACGCGGTGACTCCGCTTAGTACT
CTACTTTGCTCCGCATCCGTGGGAGCCAACGTTGCCGGCTAACCGCAAGATCGAACCAAGAGCT
CAGCCGGTGCAAGGCGGTGGCGTTTCTCCCTCGCAAGGCACCCACAACTCTGCGCACTCGCCCT
CCCTGGCGCCCTACAGCTGTGGGGCCCTACGTAGACAGGAACCACCTGGCGTGGGTTAGGGGGA
AGCAGCGCTTCTGGAAAAGCGGACCGGAAACCCGCGTCTCCCTTCCCGGACCAGCTTCCGCCTG
CCTTCTGCCAATCTGGCCTTTAAGCGACGAGGTCTCAGCAGAGTTAGAAGAAATGGCCCTGGTA
CCGTATGAGGAGAGCATGTCAATAGGGCTCCAGAAACTCCATAAGCCTCTTGCCACCTTCTCGT
TTGCAAACCACACCATCCAGATCCGTCAGGACTGGGGGCGACTGGGAGTGGCTGCAGTGGTTTG
GGATGCGGCCATTGTTCTTTCCACGTATCTGGAGATGGGTGCCGTGGAGCTCAGGGGCTGCTCT
GCCGTGGAGCTGGGAGCTGGCACAGGGCTGGTGGGCATCGTGGCTGCGCTGCTGGGTGCTCATG
TGACTATCACGGACCGAAAAGTAGCGTTAGAATTTCTTAAGTCAAATGTTGAGGCCAACTTACC
TCCCCATATCCAACCTAAGGTGGTTGTTAAGGAGCTGACTTGGGGACAAAATTTGGACAGTTTT
TCACCTGGAGAATTTGATCTCATACTTGGAGCTGATATCATATACTTAGAAGATACCTTCACAG
ACCTTCTTCAAACACTGGGACATCTCTGTAGCAACAACTCTGTGATTCTTCTAGCTTGCCGAAT
CCGCTATGAACGGGATAATAACTTCTTAACAATGCTGGAGAGGCAGTTCACTGTGAGTAAGGTT
CACTACGATCCTGAGAAGGATGTACACATTTACAAAGCACAGAAGAGAAAGCAGAGGGAGGACT
TGTAGTGGGCAGTATTTTCTAAGAATCGAATGCATCAGTTAAGGTCTTACAGCTAGAACTCTTA
GCGGTGTTAATGACGTAGCAGACTGCAAGTCATTCCTCTCAGAGCTGCTCAAGGAACAAAGCAC
GTGTGTACTTTGTAGACAATGCCTTGCCTCATTGCCGGAACTGTCAGTCAGATTGACTGTAGAT
GGACATGTGAAGTTTGGCTGGTGTTCTTTGCTTTGCCCTGTGTGCTCACTTGGTAAGCAATTTC
CACTGATAAAGAATGATATGAAGGTGTCCCTAAACTGGTGAGTCAGTCATATATTCTGGGATGT
ATTTTGTCTTAGTTTCCTTGTCTGTTGAGTGTAAACAGACTTATTATATGTCTTCCCTGAAATG
TTTGTACTGTTGCAGTCTCTTTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG
TGTGTTAGATAAAGCCTTACTCTGTAGCCCTGGGTTGGTCTGAAACTGTAGACCAGGCTGACCT
CAAGCTTGAAGTAATTCTCTTTCCTCCGCCTCCGAGTGCTGGGATTACCAGCGTGTGCCATGCC
ACCTGGCTATTTGGTTCTTAAGCACCTTGAGTTGAAGATGAGTTTTCTGGCTCTCATATCATAC
CTTCTTACCAGATTTCAGGGTTAAGTATATAAGCAAAGAAATAATAAAAATAAAAGTTTACATT
TGAAATTA

hide sequence

RefSeq Acc Id:

XM_039084579 ⟹ XP_038940507

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	9	65,978,036 - 65,987,091 (-)	NCBI

RefSeq Acc Id:

XM_039084580 ⟹ XP_038940508

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	9	65,978,036 - 65,999,964 (-)	NCBI

RefSeq Acc Id:

XM_039084581 ⟹ XP_038940509

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	9	65,985,115 - 65,987,091 (-)	NCBI

RefSeq Acc Id:

XM_039084582 ⟹ XP_038940510

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	9	65,934,253 - 65,987,091 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001386380	(Get FASTA)	NCBI Sequence Viewer
	XP_006245144	(Get FASTA)	NCBI Sequence Viewer
	XP_006245145	(Get FASTA)	NCBI Sequence Viewer
	XP_038940507	(Get FASTA)	NCBI Sequence Viewer
	XP_038940508	(Get FASTA)	NCBI Sequence Viewer
	XP_038940509	(Get FASTA)	NCBI Sequence Viewer
	XP_038940510	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	XP_006245145 ⟸ XM_006245083
- Peptide Label:	isoform X1
- UniProtKB:	D4A8Z5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MALVPYEESMSIGLQKLHKPLATFSFANHTIQIRQDWGRLGVAAVVWDAAIVLSTYLEMGAVEL RGCSAVELGAGTGLVGIVAALLGAHVTITDRKVALEFLKSNVEANLPPHIQPKVVVKELTWGQN LDSFSPGEFDLILGADIIYLEDTFTDLLQTLGHLCSNNSVILLACRIRYERDNNFLTMLERQFT VSKVHYDPEKDVHIYKAQKRKQREDL hide sequence

RefSeq Acc Id:	XP_006245144 ⟸ XM_006245082
- Peptide Label:	isoform X1
- UniProtKB:	D4A8Z5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MALVPYEESMSIGLQKLHKPLATFSFANHTIQIRQDWGRLGVAAVVWDAAIVLSTYLEMGAVEL RGCSAVELGAGTGLVGIVAALLGAHVTITDRKVALEFLKSNVEANLPPHIQPKVVVKELTWGQN LDSFSPGEFDLILGADIIYLEDTFTDLLQTLGHLCSNNSVILLACRIRYERDNNFLTMLERQFT VSKVHYDPEKDVHIYKAQKRKQREDL hide sequence

RefSeq Acc Id:

ENSRNOP00000019670 ⟸ ENSRNOT00000019670

RefSeq Acc Id:	XP_038940510 ⟸ XM_039084582
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038940508 ⟸ XM_039084580
- Peptide Label:	isoform X1
- UniProtKB:	D4A8Z5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038940507 ⟸ XM_039084579
- Peptide Label:	isoform X1
- UniProtKB:	D4A8Z5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038940509 ⟸ XM_039084581
- Peptide Label:	isoform X2

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A8Z5-F1-model_v2	AlphaFold	D4A8Z5	1-218	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:7651604	AgrOrtholog
BioCyc Gene	G2FUF-27318	BioCyc
Ensembl Genes	ENSRNOG00000014212	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000019670	ENTREZGENE
	ENSRNOP00000019670.3	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000019670	ENTREZGENE
	ENSRNOT00000019670.7	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.150	UniProtKB/TrEMBL
InterPro	Nicotinamide_N-MeTfrase-like	UniProtKB/TrEMBL
	SAM-dependent_MTases	UniProtKB/TrEMBL
KEGG Report	rno:102553119	UniProtKB/TrEMBL
NCBI Gene	LOC102553119	ENTREZGENE
PANTHER	PROTEIN N-LYSINE METHYLTRANSFERASE METTL21A	UniProtKB/TrEMBL
	PTHR14614	UniProtKB/TrEMBL
Pfam	Methyltransf_16	UniProtKB/TrEMBL
PhenoGen	Mettl21a	PhenoGen
Superfamily-SCOP	SSF53335	UniProtKB/TrEMBL
UniProt	D4A8Z5	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-06-17	Mettl21a	methyltransferase 21A, HSPA lysine	Mettl21a	methyltransferase like 21A	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-06-26	Mettl21a	methyltransferase like 21A	LOC102553119	protein N-lysine methyltransferase METTL21A-like	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-12-18	LOC102553119	protein N-lysine methyltransferase METTL21A-like			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar