Mettl21a (methyltransferase 21A, HSPA lysine) - Rat Genome Database

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Gene: Mettl21a (methyltransferase 21A, HSPA lysine) Rattus norvegicus
Analyze
Symbol: Mettl21a
Name: methyltransferase 21A, HSPA lysine
RGD ID: 7651604
Description: Predicted to enable ATPase binding activity; Hsp70 protein binding activity; and protein-lysine N-methyltransferase activity. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Orthologous to human METTL21A (methyltransferase 21A, HSPA lysine); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A; gentamycin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fam119a; family with sequence similarity 119, member A; LOC102553119; methyltransferase like 21A; protein N-lysine methyltransferase METTL21A-like; RGD1311824
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8973,400,223 - 73,484,677 (-)NCBIGRCr8
mRatBN7.2965,934,253 - 65,999,964 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl965,978,051 - 65,987,550 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx974,497,956 - 74,507,394 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0979,628,726 - 79,638,210 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0978,033,180 - 78,042,666 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0971,304,138 - 71,314,015 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl971,304,427 - 71,313,940 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0971,262,537 - 71,272,027 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera963,384,809 - 63,394,665 (-)NCBICelera
Cytogenetic Map9q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22948820   PMID:23349634   PMID:23921388  


Genomics

Comparative Map Data
Mettl21a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8973,400,223 - 73,484,677 (-)NCBIGRCr8
mRatBN7.2965,934,253 - 65,999,964 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl965,978,051 - 65,987,550 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx974,497,956 - 74,507,394 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0979,628,726 - 79,638,210 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0978,033,180 - 78,042,666 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0971,304,138 - 71,314,015 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl971,304,427 - 71,313,940 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0971,262,537 - 71,272,027 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera963,384,809 - 63,394,665 (-)NCBICelera
Cytogenetic Map9q32NCBI
METTL21A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382207,580,635 - 207,626,053 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2207,580,631 - 207,625,928 (-)EnsemblGRCh38hg38GRCh38
GRCh372208,445,359 - 208,490,777 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362208,185,071 - 208,197,953 (-)NCBINCBI36Build 36hg18NCBI36
Celera2202,237,420 - 202,251,254 (-)NCBICelera
Cytogenetic Map2q33.3NCBI
HuRef2200,316,943 - 200,331,976 (-)NCBIHuRef
CHM1_12208,479,659 - 208,495,798 (-)NCBICHM1_1
T2T-CHM13v2.02208,054,650 - 208,100,120 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2776,470,923 - 76,472,979 (-)NCBI
Mettl21a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39164,645,632 - 64,661,926 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl164,645,632 - 64,656,401 (-)EnsemblGRCm39 Ensembl
GRCm38164,606,473 - 64,620,466 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl164,606,473 - 64,617,242 (-)EnsemblGRCm38mm10GRCm38
MGSCv37164,653,054 - 64,663,742 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36164,540,756 - 64,551,444 (-)NCBIMGSCv36mm8
Celera165,107,887 - 65,118,599 (-)NCBICelera
Cytogenetic Map1C2NCBI
cM Map132.74NCBI
Mettl21a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554577,411,218 - 7,421,832 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554577,411,218 - 7,421,832 (+)NCBIChiLan1.0ChiLan1.0
METTL21A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213110,188,087 - 110,230,171 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B110,203,149 - 110,245,150 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B94,814,225 - 94,856,558 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B212,941,308 - 212,983,823 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B212,969,269 - 212,983,177 (-)Ensemblpanpan1.1panPan2
METTL21A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13715,935,256 - 16,002,089 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3715,990,763 - 16,002,256 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3716,819,122 - 16,887,414 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03715,870,812 - 15,938,784 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3715,871,304 - 15,937,716 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13715,816,578 - 15,882,999 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03715,789,688 - 15,857,867 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03715,798,900 - 15,867,034 (-)NCBIUU_Cfam_GSD_1.0
Mettl21a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303164,154,512 - 164,169,808 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366313,788,754 - 3,804,844 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366313,789,577 - 3,804,747 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
METTL21A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15110,763,382 - 110,789,466 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115110,777,577 - 110,789,466 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215122,362,833 - 122,374,726 (+)NCBISscrofa10.2Sscrofa10.2susScr3
METTL21A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11093,400,602 - 93,416,630 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1093,398,111 - 93,416,535 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040105,959,260 - 106,005,610 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mettl21a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247658,354,692 - 8,367,200 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247658,354,693 - 8,421,768 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mettl21a
235 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3
Count of miRNA genes:3
Interacting mature miRNAs:3
Transcripts:ENSRNOT00000019670
Prediction methods:Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)94996854671098346Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 4 4 43 14 36
Low 3 43 53 37 19 37 8 11 31 21 5 11 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000019670   ⟹   ENSRNOP00000019670
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl965,978,051 - 65,987,550 (-)Ensembl
Rnor_6.0 Ensembl971,304,427 - 71,313,940 (-)Ensembl
RefSeq Acc Id: NM_001399451   ⟹   NP_001386380
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8973,471,813 - 73,481,339 (-)NCBI
mRatBN7.2965,978,036 - 65,987,565 (-)NCBI
RefSeq Acc Id: XM_006245082   ⟹   XP_006245144
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8973,471,813 - 73,480,863 (-)NCBI
mRatBN7.2965,978,036 - 65,987,090 (-)NCBI
Rnor_6.0971,304,138 - 71,313,524 (-)NCBI
Rnor_5.0971,262,537 - 71,272,027 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039084579   ⟹   XP_038940507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8973,471,813 - 73,480,859 (-)NCBI
mRatBN7.2965,978,036 - 65,987,091 (-)NCBI
RefSeq Acc Id: XM_039084582   ⟹   XP_038940510
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8973,400,223 - 73,480,863 (-)NCBI
mRatBN7.2965,934,253 - 65,987,091 (-)NCBI
RefSeq Acc Id: XM_063266521   ⟹   XP_063122591
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8973,471,813 - 73,480,864 (-)NCBI
RefSeq Acc Id: XM_063266522   ⟹   XP_063122592
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8973,471,813 - 73,480,865 (-)NCBI
RefSeq Acc Id: XM_063266523   ⟹   XP_063122593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8973,400,223 - 73,484,677 (-)NCBI
RefSeq Acc Id: XM_063266524   ⟹   XP_063122594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8973,471,813 - 73,480,856 (-)NCBI
RefSeq Acc Id: XR_010054552
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8973,400,223 - 73,480,863 (-)NCBI
RefSeq Acc Id: XP_006245144   ⟸   XM_006245082
- Peptide Label: isoform X1
- UniProtKB: D4A8Z5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000019670   ⟸   ENSRNOT00000019670
RefSeq Acc Id: XP_038940510   ⟸   XM_039084582
- Peptide Label: isoform X4
- UniProtKB: A6IPI2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038940507   ⟸   XM_039084579
- Peptide Label: isoform X1
- UniProtKB: D4A8Z5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001386380   ⟸   NM_001399451
- UniProtKB: D4A8Z5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122593   ⟸   XM_063266523
- Peptide Label: isoform X4
- UniProtKB: A6IPI2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122592   ⟸   XM_063266522
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063122591   ⟸   XM_063266521
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063122594   ⟸   XM_063266524
- Peptide Label: isoform X5

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A8Z5-F1-model_v2 AlphaFold D4A8Z5 1-218 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:7651604 AgrOrtholog
BioCyc Gene G2FUF-27318 BioCyc
Ensembl Genes ENSRNOG00000014212 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019670.7 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.150 UniProtKB/TrEMBL
InterPro Nicotinamide_N-MeTfrase-like UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/TrEMBL
KEGG Report rno:102553119 UniProtKB/TrEMBL
NCBI Gene LOC102553119 ENTREZGENE
PANTHER PROTEIN N-LYSINE METHYLTRANSFERASE METTL21A UniProtKB/TrEMBL
  PTHR14614 UniProtKB/TrEMBL
Pfam Methyltransf_16 UniProtKB/TrEMBL
PhenoGen Mettl21a PhenoGen
RatGTEx ENSRNOG00000014212 RatGTEx
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
UniProt A6IPI2 ENTREZGENE, UniProtKB/TrEMBL
  D4A8Z5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-17 Mettl21a  methyltransferase 21A, HSPA lysine  Mettl21a  methyltransferase like 21A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-06-26 Mettl21a  methyltransferase like 21A  LOC102553119  protein N-lysine methyltransferase METTL21A-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-18 LOC102553119  protein N-lysine methyltransferase METTL21A-like      Symbol and Name status set to provisional 70820 PROVISIONAL