LOC102550446 (rho GTPase-activating protein 20-like) - Rat Genome Database

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Gene: LOC102550446 (rho GTPase-activating protein 20-like) Rattus norvegicus
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Symbol: LOC102550446
Name: rho GTPase-activating protein 20-like
RGD ID: 7642297
Description: Predicted to enable GTPase activator activity. Predicted to be involved in regulation of Rho protein signal transduction and signal transduction.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: uncharacterized protein LOC102550446
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82135,357,947 - 135,468,865 (+)NCBIGRCr8
mRatBN7.22133,296,630 - 133,407,312 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2133,370,317 - 133,407,318 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.02137,363,124 - 137,405,118 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02156,851,202 - 156,893,755 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Cytogenetic Map2q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

Genomics

Variants

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Variants in LOC102550446
681 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
7207808Bmd89Bone mineral density QTL 894.1femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)288862519133862519Rat
2300165Bmd49Bone mineral density QTL 494.80.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)288862519133862519Rat
2300170Bmd45Bone mineral density QTL 4512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
2300185Bmd46Bone mineral density QTL 468.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
1598862Glom9Glomerulus QTL 93.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)292337601137337601Rat
1598863Cm65Cardiac mass QTL 652.3heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)292337601137337601Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2112103657148076632Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1354594Despr10Despair related QTL 100.00000249locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2114654253159654253Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527143657569Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527143657569Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2118111229149559726Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2118111229157142209Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2118189491163189491Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2127447387143657569Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2129164097152195315Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat


Expression


Sequence


RefSeq Acc Id: ENSRNOT00000104036   ⟹   ENSRNOP00000076796
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2133,370,317 - 133,407,318 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115621   ⟹   ENSRNOP00000077796
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2133,370,317 - 133,407,318 (+)Ensembl
RefSeq Acc Id: XM_039103660   ⟹   XP_038959588
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82135,357,954 - 135,468,865 (+)NCBI
mRatBN7.22133,296,630 - 133,407,312 (+)NCBI
RefSeq Acc Id: XM_039103662   ⟹   XP_038959590
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82135,430,666 - 135,468,865 (+)NCBI
mRatBN7.22133,369,193 - 133,407,312 (+)NCBI
RefSeq Acc Id: XM_039103663   ⟹   XP_038959591
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82135,431,721 - 135,468,865 (+)NCBI
mRatBN7.22133,370,187 - 133,407,312 (+)NCBI
RefSeq Acc Id: XM_039103664   ⟹   XP_038959592
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82135,357,953 - 135,468,865 (+)NCBI
mRatBN7.22133,296,630 - 133,407,312 (+)NCBI
RefSeq Acc Id: XM_039103666   ⟹   XP_038959594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82135,447,615 - 135,468,865 (+)NCBI
mRatBN7.22133,386,126 - 133,407,312 (+)NCBI
RefSeq Acc Id: XM_063282882   ⟹   XP_063138952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82135,430,666 - 135,468,865 (+)NCBI
RefSeq Acc Id: XM_063282883   ⟹   XP_063138953
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82135,431,717 - 135,468,865 (+)NCBI
RefSeq Acc Id: XM_063282884   ⟹   XP_063138954
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82135,357,947 - 135,468,865 (+)NCBI
RefSeq Acc Id: XP_038959588   ⟸   XM_039103660
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y886 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959592   ⟸   XM_039103664
- Peptide Label: isoform X2
- UniProtKB: A0A8I5Y886 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959590   ⟸   XM_039103662
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y886 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959591   ⟸   XM_039103663
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y886 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959594   ⟸   XM_039103666
- Peptide Label: isoform X5
RefSeq Acc Id: ENSRNOP00000076796   ⟸   ENSRNOT00000104036
RefSeq Acc Id: ENSRNOP00000077796   ⟸   ENSRNOT00000115621
RefSeq Acc Id: XP_063138954   ⟸   XM_063282884
- Peptide Label: isoform X4
- UniProtKB: A0A8I5Y886 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138952   ⟸   XM_063282882
- Peptide Label: isoform X3
- UniProtKB: A0A8I5Y886 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138953   ⟸   XM_063282883
- Peptide Label: isoform X3
- UniProtKB: A0A8I5Y886 (UniProtKB/TrEMBL)
Protein Domains
Ras-associating   Rho-GAP

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-53153 BioCyc
Ensembl Genes ENSRNOG00000065262 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000104036.1 UniProtKB/TrEMBL
  ENSRNOT00000115621.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.555.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro ARHGAP20-like_RhoGAP UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  RA_dom UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
NCBI Gene LOC102550446 ENTREZGENE
PANTHER GENE 1527-RELATED UniProtKB/TrEMBL
  T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED UniProtKB/TrEMBL
Pfam PF00788 UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
PhenoGen LOC102550446 PhenoGen
PROSITE PS50200 UniProtKB/TrEMBL
  RHOGAP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000065262 RatGTEx
SMART RhoGAP UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF48350 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A8I5Y0S9_RAT UniProtKB/TrEMBL
  A0A8I5Y886 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-12-18 LOC102550446  rho GTPase-activating protein 20-like      Symbol and Name status set to provisional 70820 PROVISIONAL