Cbr1l2 (carbonyl reductase 1 like 2) - Rat Genome Database

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Gene: Cbr1l2 (carbonyl reductase 1 like 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cbr1l2
Name: carbonyl reductase 1 like 2
RGD ID: 7631561
Description: Predicted to enable carbonyl reductase (NADPH) activity. Predicted to be involved in lipid metabolic process. Predicted to be located in cytoplasm. Orthologous to human CBR1 (carbonyl reductase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: carbonyl reductase [NADPH] 1; carbonyl reductase [NADPH] 1-like; carbonyl reductase isoform III; LOC102556347
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81146,378,474 - 46,381,104 (+)NCBIGRCr8
mRatBN7.21132,892,640 - 32,895,277 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1132,857,991 - 32,895,275 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01133,863,427 - 33,865,930 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1133,812,662 - 33,865,933 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01137,455,010 - 37,457,505 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Synaptotagmin 11 interacts with components of the RNA-induced silencing complex RISC in clonal pancreatic beta-cells. Milochau A, etal., FEBS Lett. 2014 Jun 27;588(14):2217-22. doi: 10.1016/j.febslet.2014.05.031. Epub 2014 May 29.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10642578   PMID:18449627   PMID:19442656   PMID:21492153  


Genomics

Variants

.
Variants in Cbr1l2
9 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11135331169Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111945620576331918Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000042283   ⟹   ENSRNOP00000043385
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1132,860,563 - 32,879,189 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000072384   ⟹   ENSRNOP00000064050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1132,860,524 - 32,895,274 (+)Ensembl
Rnor_6.0 Ensembl1133,863,500 - 33,865,930 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000075105   ⟹   ENSRNOP00000081570
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1132,876,757 - 32,895,275 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000075985   ⟹   ENSRNOP00000067964
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1132,876,757 - 32,877,965 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085961   ⟹   ENSRNOP00000073686
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1132,892,784 - 32,895,274 (+)Ensembl
Rnor_6.0 Ensembl1133,812,662 - 33,865,933 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096883   ⟹   ENSRNOP00000077145
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1132,857,991 - 32,862,978 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114595   ⟹   ENSRNOP00000082202
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1132,892,784 - 32,894,046 (+)Ensembl
RefSeq Acc Id: XM_006248109   ⟹   XP_006248171
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81146,378,474 - 46,381,104 (+)NCBI
mRatBN7.21132,892,640 - 32,895,277 (+)NCBI
Rnor_6.01133,863,427 - 33,865,930 (+)NCBI
Rnor_5.01137,455,010 - 37,457,505 (+)NCBI
Sequence:
RefSeq Acc Id: XP_006248171   ⟸   XM_006248109
- Sequence:
Ensembl Acc Id: ENSRNOP00000073686   ⟸   ENSRNOT00000085961
Ensembl Acc Id: ENSRNOP00000064050   ⟸   ENSRNOT00000072384
Ensembl Acc Id: ENSRNOP00000067964   ⟸   ENSRNOT00000075985
Ensembl Acc Id: ENSRNOP00000077145   ⟸   ENSRNOT00000096883
Ensembl Acc Id: ENSRNOP00000043385   ⟸   ENSRNOT00000042283
Ensembl Acc Id: ENSRNOP00000082202   ⟸   ENSRNOT00000114595
Ensembl Acc Id: ENSRNOP00000081570   ⟸   ENSRNOT00000075105

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K658-F1-model_v2 AlphaFold A0A0G2K658 1-329 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698074
Promoter ID:EPDNEW_R8597
Type:initiation region
Name:LOC102556347_1
Description:carbonyl reductase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01133,863,481 - 33,863,541EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:7631561 AgrOrtholog
BioCyc Gene G2FUF-21807 BioCyc
Ensembl Genes ENSRNOG00000049911 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072384.3 UniProtKB/TrEMBL
  ENSRNOT00000075105.3 UniProtKB/TrEMBL
  ENSRNOT00000075985.2 UniProtKB/TrEMBL
  ENSRNOT00000085961.2 UniProtKB/TrEMBL
  ENSRNOT00000096883.1 UniProtKB/TrEMBL
  ENSRNOT00000114595.1 UniProtKB/TrEMBL
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro CBR1-like UniProtKB/TrEMBL
  Glc/ribitol_DH UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  Sc_DH/Rdtase_CS UniProtKB/TrEMBL
NCBI Gene LOC102556347 ENTREZGENE
PANTHER CARBONYL REDUCTASE 1-RELATED UniProtKB/TrEMBL
  CARBONYL REDUCTASE [NADPH] 1 UniProtKB/TrEMBL
Pfam adh_short UniProtKB/TrEMBL
PhenoGen Cbr1l2 PhenoGen
PRINTS GDHRDH UniProtKB/TrEMBL
  SDRFAMILY UniProtKB/TrEMBL
PROSITE ADH_SHORT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000049911 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/TrEMBL
UniProt A0A096MJ24_RAT UniProtKB/TrEMBL
  A0A0G2K658_RAT UniProtKB/TrEMBL
  A0A8I5XVU2_RAT UniProtKB/TrEMBL
  A0A8I5ZT21_RAT UniProtKB/TrEMBL
  A0A8I5ZUP5 ENTREZGENE, UniProtKB/TrEMBL
  M0R3X6 ENTREZGENE, UniProtKB/TrEMBL
  O08558 ENTREZGENE
  P47727 ENTREZGENE
  Q3KR58 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-18 Cbr1l2  carbonyl reductase 1 like 2  LOC102556347  carbonyl reductase [NADPH] 1-like  Name and Symbol changed 629549 APPROVED
2013-12-18 LOC102556347  carbonyl reductase [NADPH] 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL