Mas1l (MAS1 proto-oncogene like, G protein-coupled receptor) - Rat Genome Database

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Gene: Mas1l (MAS1 proto-oncogene like, G protein-coupled receptor) Rattus norvegicus
Analyze
Symbol: Mas1l
Name: MAS1 proto-oncogene like, G protein-coupled receptor
RGD ID: 738049
Description: Predicted to enable angiotensin receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in plasma membrane. Orthologous to human MAS1L (MAS1 proto-oncogene like, G protein-coupled receptor); INTERACTS WITH bisphenol A; thioacetamide; trichloroethene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC308103; Mas-related G protein-coupled receptor b; mas-related G-protein coupled receptor member H; MAS-related G-protein coupled receptor, member H; MAS-related gene H; MAS-related GPR, member H; Mgrb; MrgH,GPR90; MrgHGPR90; Mrgprh
RGD Orthologs
Human
Mouse
Bonobo
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,416,178 - 50,427,730 (-)NCBIGRCr8
mRatBN7.2147,871,592 - 47,879,942 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx148,564,118 - 48,565,083 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,549,908 - 54,550,873 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,639,637 - 48,640,602 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0148,068,389 - 48,206,902 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,069,194 - 48,070,536 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,546,345 - 51,683,995 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,146,949 - 42,147,914 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1142,149,893 - 42,150,859 (-)NCBI
Celera143,672,936 - 43,673,901 (-)NCBICelera
Cytogenetic Map1q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
megacolon  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (ISO)
nucleoplasm  (ISO)
plasma membrane  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family. Zylka MJ, etal., Proc Natl Acad Sci U S A 2003 Aug 19;100(17):10043-8. Epub 2003 Aug 8.
Additional References at PubMed
PMID:24583173  


Genomics

Comparative Map Data
Mas1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,416,178 - 50,427,730 (-)NCBIGRCr8
mRatBN7.2147,871,592 - 47,879,942 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx148,564,118 - 48,565,083 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,549,908 - 54,550,873 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,639,637 - 48,640,602 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0148,068,389 - 48,206,902 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,069,194 - 48,070,536 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,546,345 - 51,683,995 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,146,949 - 42,147,914 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1142,149,893 - 42,150,859 (-)NCBI
Celera143,672,936 - 43,673,901 (-)NCBICelera
Cytogenetic Map1q11NCBI
MAS1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38629,486,697 - 29,487,956 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl629,486,697 - 29,487,956 (-)EnsemblGRCh38hg38GRCh38
GRCh37629,454,474 - 29,455,733 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36629,562,522 - 29,563,658 (-)NCBINCBI36Build 36hg18NCBI36
Build 34629,562,521 - 29,563,658NCBI
Celera631,060,587 - 31,061,723 (-)NCBICelera
Cytogenetic Map6p22.1NCBI
HuRef629,261,701 - 29,262,837 (-)NCBIHuRef
CHM1_1629,456,662 - 29,457,798 (-)NCBICHM1_1
T2T-CHM13v2.0629,361,354 - 29,362,613 (-)NCBIT2T-CHM13v2.0
Mrgprh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391713,094,921 - 13,096,729 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1713,094,921 - 13,096,864 (+)EnsemblGRCm39 Ensembl
GRCm381712,876,034 - 12,877,842 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1712,876,034 - 12,877,977 (+)EnsemblGRCm38mm10GRCm38
MGSCv371713,068,900 - 13,070,708 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361712,718,966 - 12,720,774 (+)NCBIMGSCv36mm8
Celera1712,907,930 - 12,909,738 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.7NCBI
MAS1L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2544,110,393 - 44,172,799 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1640,073,708 - 40,136,145 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0629,295,079 - 29,357,477 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1629,955,683 - 29,957,161 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl629,955,952 - 29,957,161 (-)Ensemblpanpan1.1panPan2

Variants

.
Variants in Mas1l
23 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:26
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000020070
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 11 29 57 37 33 8 14 8 6 114 66 37 26 50 25

Sequence


Ensembl Acc Id: ENSRNOT00000020070   ⟹   ENSRNOP00000020070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl148,069,194 - 48,070,536 (-)Ensembl
RefSeq Acc Id: NM_001002281   ⟹   NP_001002281
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,420,253 - 50,421,218 (-)NCBI
mRatBN7.2147,872,474 - 47,873,439 (-)NCBI
Rnor_6.0148,069,196 - 48,070,161 (-)NCBI
Rnor_5.0151,546,345 - 51,683,995 (+)NCBI
RGSC_v3.4142,146,949 - 42,147,914 (-)RGD
Celera143,672,936 - 43,673,901 (-)RGD
Sequence:
RefSeq Acc Id: XM_006227882   ⟹   XP_006227944
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,416,178 - 50,427,730 (-)NCBI
mRatBN7.2147,871,592 - 47,879,942 (-)NCBI
Rnor_6.0148,068,389 - 48,076,764 (-)NCBI
Rnor_5.0151,546,345 - 51,683,995 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001002281 (Get FASTA)   NCBI Sequence Viewer  
  XP_006227944 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAQ08321 (Get FASTA)   NCBI Sequence Viewer  
  CDG86235 (Get FASTA)   NCBI Sequence Viewer  
  Q7TN38 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001002281   ⟸   NM_001002281
- UniProtKB: Q7TN38 (UniProtKB/Swiss-Prot),   W8W3K0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006227944   ⟸   XM_006227882
- Peptide Label: isoform X1
- UniProtKB: Q7TN38 (UniProtKB/Swiss-Prot),   W8W3K0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020070   ⟸   ENSRNOT00000020070
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TN38-F1-model_v2 AlphaFold Q7TN38 1-321 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:738049 AgrOrtholog
BioCyc Gene G2FUF-61578 BioCyc
Ensembl Genes ENSRNOG00000014965 Ensembl
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:404641 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 404641 ENTREZGENE
PANTHER PTHR11334 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11334:SF60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mas1l PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014965 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt MRGRH_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  W8W3K0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-15 Mas1l  MAS1 proto-oncogene like, G protein-coupled receptor  Mrgprh  MAS-related GPR, member H  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Mrgprh  MAS-related GPR, member H  Mrgprh  MAS-related G-protein coupled receptor, member H  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-04-06 Mrgprh  MAS-related G-protein coupled receptor, member H  Mrgprh_predicted  MAS-related GPR, member H (predicted)  Data merged from RGD:1310599 737654 APPROVED
2005-09-30 Mrgprh        Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Mrgprh_predicted  MAS-related GPR, member H (predicted)      Symbol and Name status set to approved 70820 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in nociceptive sensory neurons, dorsal root ganglia, and in trigeminal ganglia 737883
gene_product member of the Mas-related gene (Mrg) family, based on the ligand which activates the receptor 737883