Slc11a2 (solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2) - Rat Genome Database

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Gene: Slc11a2 (solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2) Mus musculus
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Symbol: Slc11a2
Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
RGD ID: 737579
MGI Page MGI
Description: Enables cobalt ion transmembrane transporter activity. Acts upstream of or within several processes, including erythrocyte development; multicellular organismal-level iron ion homeostasis; and transition metal ion transport. Located in brush border membrane; endosome; and extracellular vesicle. Is expressed in embryo; intestine; small intestine; and yolk sac. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; anemia; and hypochromic anemia. Orthologous to human SLC11A2 (solute carrier family 11 member 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DCT1; divalent cation transporter 1; divalent metal transporter 1; DMT-1; DMT1; microcytic anemia, viable anaemia; mk; natural resistance-associated macrophage protein 2; Nr; NRAMP 2; Nramp2; solute carrier family 11 member 2; van
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915100,285,779 - 100,322,090 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15100,285,779 - 100,322,953 (-)EnsemblGRCm39 Ensembl
GRCm3815100,387,898 - 100,424,209 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15100,387,898 - 100,425,072 (-)EnsemblGRCm38mm10GRCm38
MGSCv3715100,218,329 - 100,253,486 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615100,215,932 - 100,251,017 (-)NCBIMGSCv36mm8
Celera15102,539,003 - 102,574,160 (-)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.29NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP)
alcohol  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP)
amitrole  (ISO)
ammonium chloride  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
astragaloside IV  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
captan  (EXP)
chlorogenic acid  (ISO)
chlorpyrifos  (EXP)
chromium(6+)  (EXP,ISO)
clobetasol  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
deferiprone  (ISO)
deguelin  (ISO)
desferrioxamine B  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diltiazem  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
ebselen  (ISO)
elemental selenium  (ISO)
erastin  (ISO)
ethanol  (EXP)
ferric ammonium citrate  (EXP)
flutamide  (ISO)
folpet  (EXP)
gamma-hexachlorocyclohexane  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
glucose  (EXP,ISO)
hydrogen peroxide  (ISO)
iron atom  (EXP,ISO)
iron dextran  (EXP,ISO)
iron trichloride  (ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (ISO)
iron(III) nitrilotriacetate  (ISO)
isobutanol  (ISO)
isotretinoin  (ISO)
kainic acid  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
lead(II) chloride  (EXP)
lipopolysaccharide  (EXP,ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mercury atom  (EXP,ISO)
mercury(0)  (EXP,ISO)
methapyrilene  (ISO)
methidathion  (EXP)
methimazole  (ISO)
methoxychlor  (ISO)
Methylazoxymethanol acetate  (ISO)
methylmercury chloride  (ISO)
mithramycin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nimodipine  (EXP)
nitric oxide  (EXP,ISO)
nitroprusside  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (EXP)
phenobarbital  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (EXP,ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
staurosporine  (EXP)
succimer  (EXP,ISO)
sulfadimethoxine  (ISO)
tamoxifen  (EXP)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (EXP,ISO)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trovafloxacin  (EXP)
tunicamycin  (ISO)
undecane  (ISO)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vanadium atom  (ISO)
vanadium dioxide  (ISO)
vanadium(0)  (ISO)
verapamil  (EXP)
vitamin E  (EXP,ISO)
Yessotoxin  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc oxide  (EXP)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Two new human DMT1 gene mutations in a patient with microcytic anemia, low ferritinemia, and liver iron overload. Beaumont C, etal., Blood. 2006 May 15;107(10):4168-70. Epub 2006 Jan 26.
2. Association between divalent metal transport 1 encoding gene (SLC11A2) and disease duration in amyotrophic lateral sclerosis. Blasco H, etal., J Neurol Sci. 2011 Apr 15;303(1-2):124-7. Epub 2011 Jan 26.
3. Restless legs syndrome-associated MEIS1 risk variant influences iron homeostasis. Catoire H, etal., Ann Neurol. 2011 Jul;70(1):170-5. doi: 10.1002/ana.22435. Epub 2011 Jun 27.
4. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Fleming MD, etal., Nat Genet. 1997 Aug;16(4):383-6.
5. Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. Fleming MD, etal., Proc Natl Acad Sci U S A 1998 Feb 3;95(3):1148-53.
6. DMT1 polymorphism and risk of Parkinson's disease. He Q, etal., Neurosci Lett. 2011 Sep 1;501(3):128-31. Epub 2011 Jul 12.
7. Up-regulation of divalent metal transporter 1 in 6-hydroxydopamine intoxication is IRE/IRP dependent. Jiang H, etal., Cell Res. 2010 Mar;20(3):345-56. Epub 2010 Feb 2.
8. Role of iron in the pathogenesis of cysteamine-induced duodenal ulceration in rats. Khomenko T, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Jun;296(6):G1277-86. doi: 10.1152/ajpgi.90257.2008. Epub 2009 Apr 2.
9. Influence of DMT1 and iron status on inflammatory responses in the lung. Kim J, etal., Am J Physiol Lung Cell Mol Physiol. 2011 Apr;300(4):L659-65. Epub 2011 Jan 28.
10. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Lane DJ, etal., Biochim Biophys Acta. 2015 May;1853(5):1130-44. doi: 10.1016/j.bbamcr.2015.01.021. Epub 2015 Feb 4.
11. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
12. MGDs mouse GO annotations MGD data from the GO Consortium
13. MGD IEA MGD IEA
14. Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload. Mims MP, etal., Blood. 2005 Feb 1;105(3):1337-42. Epub 2004 Sep 30.
15. The significance of the mutated divalent metal transporter (DMT1) on iron transport into the Belgrade rat brain. Moos T and Morgan EH, J Neurochem. 2004 Jan;88(1):233-45.
16. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
17. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. Mouse MP Annotation Import Pipeline RGD automated import pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease. Salazar J, etal., Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18578-83. Epub 2008 Nov 14.
22. Olfactory uptake of manganese requires DMT1 and is enhanced by anemia. Thompson K, etal., FASEB J. 2007 Jan;21(1):223-30. Epub 2006 Nov 20.
23. Molecular genetic studies of DMT1 on 12q in French-Canadian restless legs syndrome patients and families. Xiong L, etal., Am J Med Genet B Neuropsychiatr Genet. 2007 Oct 5;144B(7):911-7.
24. Deficiency in the divalent metal transporter 1 increases bleomycin-induced lung injury. Yang F, etal., Biometals. 2010 Aug;23(4):657-67. Epub 2010 Mar 25.
25. Tanshinone IIA prevented brain iron dyshomeostasis in cerebral ischemic rats. Yang L, etal., Cell Physiol Biochem. 2011;27(1):23-30. Epub 2011 Feb 11.
Additional References at PubMed
PMID:658175   PMID:782924   PMID:807277   PMID:2744761   PMID:3366378   PMID:4404581   PMID:4563452   PMID:5070129   PMID:5427253   PMID:5507573   PMID:5521744   PMID:7613023  
PMID:7789986   PMID:7995373   PMID:8469289   PMID:8661115   PMID:8703126   PMID:8889548   PMID:10077651   PMID:10349636   PMID:10577506   PMID:10791995   PMID:10922068   PMID:10942769  
PMID:11042159   PMID:11076861   PMID:11090085   PMID:11159549   PMID:11175792   PMID:11217851   PMID:11739192   PMID:11741608   PMID:11964145   PMID:12081573   PMID:12209011   PMID:12239176  
PMID:12477932   PMID:12522007   PMID:12576298   PMID:12724326   PMID:12743117   PMID:12776125   PMID:14610273   PMID:14618243   PMID:14681479   PMID:15024413   PMID:15139022   PMID:15469906  
PMID:15764147   PMID:15782199   PMID:15849611   PMID:15994289   PMID:16023393   PMID:16141072   PMID:16141073   PMID:16142913   PMID:16227996   PMID:16475818   PMID:16787915   PMID:16905747  
PMID:16936804   PMID:17097837   PMID:17262811   PMID:17293870   PMID:17932044   PMID:18076961   PMID:18177727   PMID:18653481   PMID:18722041   PMID:18723004   PMID:18776082   PMID:18799693  
PMID:19211831   PMID:19252488   PMID:19596281   PMID:19621945   PMID:19679638   PMID:20394798   PMID:20558581   PMID:20959604   PMID:21267068   PMID:21436314   PMID:21873635   PMID:22534978  
PMID:22666436   PMID:23000401   PMID:23064962   PMID:23508576   PMID:24045836   PMID:24282296   PMID:24327293   PMID:25467637   PMID:25562168   PMID:25772431   PMID:25862412   PMID:26294671  
PMID:27048792   PMID:27325674   PMID:27462458   PMID:27546461   PMID:28672025   PMID:29799838   PMID:30190412   PMID:30309285   PMID:30352047   PMID:30423260   PMID:31676601   PMID:32542311  
PMID:33443215   PMID:34063414   PMID:34360779   PMID:34460113   PMID:35181698   PMID:35743233   PMID:36398730   PMID:38141840   PMID:38331112   PMID:38634270  


Genomics

Comparative Map Data
Slc11a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915100,285,779 - 100,322,090 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15100,285,779 - 100,322,953 (-)EnsemblGRCm39 Ensembl
GRCm3815100,387,898 - 100,424,209 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15100,387,898 - 100,425,072 (-)EnsemblGRCm38mm10GRCm38
MGSCv3715100,218,329 - 100,253,486 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615100,215,932 - 100,251,017 (-)NCBIMGSCv36mm8
Celera15102,539,003 - 102,574,160 (-)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.29NCBI
SLC11A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381250,952,263 - 51,028,886 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1250,979,401 - 51,028,566 (-)EnsemblGRCh38hg38GRCh38
GRCh371251,373,190 - 51,422,669 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361249,666,044 - 49,706,409 (-)NCBINCBI36Build 36hg18NCBI36
Build 341249,666,043 - 49,706,409NCBI
Celera1250,175,791 - 50,224,278 (-)NCBICelera
Cytogenetic Map12q13.12NCBI
HuRef1248,405,542 - 48,453,948 (-)NCBIHuRef
CHM1_11251,339,878 - 51,388,358 (-)NCBICHM1_1
T2T-CHM13v2.01250,915,621 - 50,992,224 (-)NCBIT2T-CHM13v2.0
Slc11a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87133,381,878 - 133,429,921 (-)NCBIGRCr8
mRatBN7.27131,503,076 - 131,540,246 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7131,503,081 - 131,540,145 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7133,305,973 - 133,342,852 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07135,531,551 - 135,568,430 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07135,444,055 - 135,481,251 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07142,025,812 - 142,062,892 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,025,815 - 142,063,212 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07139,833,529 - 139,870,819 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47139,094,505 - 139,127,427 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17139,170,941 - 139,203,864 (-)NCBI
Celera7127,985,198 - 128,017,825 (-)NCBICelera
Cytogenetic Map7q36NCBI
SLC11A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21043,160,550 - 43,207,136 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11243,157,312 - 43,212,817 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01237,726,158 - 37,774,554 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11238,629,576 - 38,677,377 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1238,629,686 - 38,677,377 (+)Ensemblpanpan1.1panPan2
SLC11A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,788,785 - 3,823,852 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl273,787,855 - 3,822,672 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2742,433,184 - 42,468,214 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0273,835,730 - 3,870,717 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl273,835,750 - 3,870,711 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1273,802,428 - 3,837,405 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0273,789,782 - 3,824,709 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02742,829,654 - 42,864,682 (-)NCBIUU_Cfam_GSD_1.0
Slc11a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494564,541,218 - 64,575,407 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365128,586,262 - 8,623,597 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365128,590,302 - 8,622,121 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC11A2
(Sus scrofa - pig)
No map positions available.
SLC11A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11147,190,138 - 47,238,543 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1147,197,168 - 47,235,130 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037198,862,999 - 198,915,680 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc11a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248161,345,006 - 1,384,299 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248161,345,020 - 1,389,615 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc11a2
1224 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2178
Count of miRNA genes:870
Interacting mature miRNAs:1191
Transcripts:ENSMUST00000023774, ENSMUST00000123461, ENSMUST00000124324, ENSMUST00000136168, ENSMUST00000138843, ENSMUST00000140535, ENSMUST00000154331, ENSMUST00000154676
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156129481100797881Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402203102896555Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800146102008435Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578416103425899Mouse
26884399Humsd1_mhumerus midshaft diameter 1, 5 week (mouse)1548363396101708435Mouse
1302074Bmd4_mbone mineral density 4 (mouse)Not determined1556186708103425899Mouse
1302197Bhr2_mbronchial hyperresponsiveness 2 (mouse)Not determined1564306334103425899Mouse
4141921Pstc3_mperiosteal circumference 3 (mouse)Not determined1567270698101270847Mouse
1300627Sluc26_msusceptibility to lung cancer 26 (mouse)Not determined1570345653104073951Mouse
1300648Dbsty4_mdiabesity 4 (mouse)Not determined1570349271104073951Mouse
1300726Pitm4_mprion incubation time 4 (mouse)Not determined1570349271104073951Mouse
14747011Mancz13_mmandible centroid size 13 (mouse)1572382669104073951Mouse
12791003Aath8_maortic arch atherosclerosis 8 (mouse)1573430144104073951Mouse
1300851Heal4_mwound healing/regeneration 4 (mouse)Not determined1577527592104073951Mouse
4142060W3q6_mweight 3 weeks QTL 6 (mouse)Not determined78601103102901704Mouse
1357894Epfpq3_mepididymal fat percentage QTL 3 (mouse)Not determined1578601103102901704Mouse
14928306Manh79_mmandible shape 79 (mouse)1578847557104073951Mouse
12880411V125Dq11_mvitamin D active form serum level QTL 11 (mouse)1578897881104073951Mouse
10402490Dipa5_mdrug induced psychomotor activation 5 (mouse)Not determined1579163411104073951Mouse
4141897Imrfq2_mimmune response to Factor IX QTL 2 (mouse)Not determined79908940104073951Mouse
1301284Cosz3_mcocaine seizure 3 (mouse)Not determined1580313634104073951Mouse
4141902Cia37_mcollagen induced arthritis 37 (mouse)Not determined1580884933104073951Mouse
1300974Pgia9_mproteoglycan induced arthritis 9 (mouse)Not determined1580884933104073951Mouse
4141511Gdcr1_mglycerolphosphate dehydrogenase regulator 1 (mouse)Not determined82615474104073951Mouse
11530037Sluc34a_msusceptibility to lung cancer 34a (mouse)1585896437104073951Mouse
11530038Sluc34b_msusceptibility to lung cancer 34b (mouse)1585896437104073951Mouse
1357614Bmca_mbile mucin accumulation (mouse)Not determined1585896437104073951Mouse
1301918Skull22_mskull morphology 22 (mouse)Not determined1585901546104073951Mouse
4141581Dshv1_mdorsal hippocampal volume 1 (mouse)Not determined92788640103425899Mouse
14700689Carg5_mCandida albicans resistance gene 5 (mouse)1597697881103008427Mouse
11528547Sluc34_msusceptibility to lung cancer 34 (mouse)1597884933102896555Mouse

Markers in Region
L33415  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3815100,388,910 - 100,389,010UniSTSGRCm38
MGSCv3715100,219,341 - 100,219,441UniSTSGRCm37
Celera15102,540,017 - 102,540,117UniSTS
Cytogenetic Map15F1UniSTS
cM Map1559.8UniSTS
Whitehead/MRC_RH15893.09UniSTS
Slc11a2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15F1UniSTS
cM Map1559.8UniSTS
PMC129447P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3815100,394,901 - 100,395,251UniSTSGRCm38
MGSCv3715100,225,332 - 100,225,682UniSTSGRCm37
Celera15102,546,008 - 102,546,358UniSTS
Cytogenetic Map15F1UniSTS
cM Map1559.8UniSTS
PMC129447P3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3815100,387,971 - 100,388,320UniSTSGRCm38
MGSCv3715100,218,402 - 100,218,751UniSTSGRCm37
Celera15102,539,076 - 102,539,425UniSTS
Cytogenetic Map15F1UniSTS
cM Map1559.8UniSTS
UniSTS:224854  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3815100,409,485 - 100,409,586UniSTSGRCm38
MGSCv3715100,239,916 - 100,240,017UniSTSGRCm37
Celera15102,560,571 - 102,560,672UniSTS
Cytogenetic Map15F1UniSTS
cM Map1559.8UniSTS
D15Mcg1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3815100,388,366 - 100,388,440UniSTSGRCm38
GRCm3815100,388,366 - 100,388,564UniSTSGRCm38
MGSCv3715100,218,797 - 100,218,871UniSTSGRCm37
MGSCv3715100,218,797 - 100,218,995UniSTSGRCm37
Celera15102,539,471 - 102,539,671UniSTS
Celera15102,539,471 - 102,539,545UniSTS
Cytogenetic Map15F1UniSTS
cM Map1559.8UniSTS
cM Map15 UniSTS
Slc11a2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15F1UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001146161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001356952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006520577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006520578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006520579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006520580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011245487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030248381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030248382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030248383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC139571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF029758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF241827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ493663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK049856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK083478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK188425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC019137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ057283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L33415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000023774   ⟹   ENSMUSP00000023774
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15100,285,779 - 100,320,936 (-)Ensembl
GRCm38.p6 Ensembl15100,387,898 - 100,423,055 (-)Ensembl
RefSeq Acc Id: ENSMUST00000123461   ⟹   ENSMUSP00000119056
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15100,304,187 - 100,322,953 (-)Ensembl
GRCm38.p6 Ensembl15100,406,306 - 100,425,072 (-)Ensembl
RefSeq Acc Id: ENSMUST00000124324   ⟹   ENSMUSP00000114702
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15100,295,475 - 100,301,124 (-)Ensembl
GRCm38.p6 Ensembl15100,397,594 - 100,403,243 (-)Ensembl
RefSeq Acc Id: ENSMUST00000136168   ⟹   ENSMUSP00000115283
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15100,306,021 - 100,320,850 (-)Ensembl
GRCm38.p6 Ensembl15100,408,140 - 100,422,969 (-)Ensembl
RefSeq Acc Id: ENSMUST00000138843   ⟹   ENSMUSP00000116463
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15100,290,444 - 100,320,883 (-)Ensembl
GRCm38.p6 Ensembl15100,392,563 - 100,423,002 (-)Ensembl
RefSeq Acc Id: ENSMUST00000140535
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15100,295,663 - 100,301,303 (-)Ensembl
GRCm38.p6 Ensembl15100,397,782 - 100,403,422 (-)Ensembl
RefSeq Acc Id: ENSMUST00000154331   ⟹   ENSMUSP00000115357
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15100,307,150 - 100,322,095 (-)Ensembl
GRCm38.p6 Ensembl15100,409,269 - 100,424,214 (-)Ensembl
RefSeq Acc Id: ENSMUST00000154676   ⟹   ENSMUSP00000115019
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15100,307,995 - 100,321,973 (-)Ensembl
GRCm38.p6 Ensembl15100,410,114 - 100,424,092 (-)Ensembl
RefSeq Acc Id: NM_001146161   ⟹   NP_001139633
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915100,290,539 - 100,320,936 (-)NCBI
GRCm3815100,392,658 - 100,423,055 (-)NCBI
MGSCv3715100,218,329 - 100,253,486 (-)RGD
Celera15102,539,003 - 102,574,160 (-)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001356952   ⟹   NP_001343881
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915100,290,539 - 100,320,936 (-)NCBI
GRCm3815100,392,658 - 100,423,055 (-)NCBI
Sequence:
RefSeq Acc Id: NM_008732   ⟹   NP_032758
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915100,285,779 - 100,320,936 (-)NCBI
GRCm3815100,387,898 - 100,423,055 (-)NCBI
MGSCv3715100,218,329 - 100,253,486 (-)RGD
Celera15102,539,003 - 102,574,160 (-)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006520577   ⟹   XP_006520640
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915100,285,779 - 100,313,598 (-)NCBI
GRCm3815100,387,898 - 100,415,990 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006520578   ⟹   XP_006520641
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915100,285,779 - 100,320,812 (-)NCBI
GRCm3815100,387,898 - 100,422,931 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006520579   ⟹   XP_006520642
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915100,285,779 - 100,320,910 (-)NCBI
GRCm3815100,387,898 - 100,423,068 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006520580   ⟹   XP_006520643
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915100,285,779 - 100,320,936 (-)NCBI
GRCm3815100,387,898 - 100,423,068 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011245487   ⟹   XP_011243789
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915100,285,779 - 100,322,090 (-)NCBI
GRCm3815100,387,898 - 100,424,209 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030248381   ⟹   XP_030104241
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915100,290,538 - 100,320,910 (-)NCBI
GRCm3815100,392,657 - 100,423,068 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030248382   ⟹   XP_030104242
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915100,285,779 - 100,320,904 (-)NCBI
GRCm3815100,387,898 - 100,423,068 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030248383   ⟹   XP_030104243
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915100,290,538 - 100,320,878 (-)NCBI
GRCm3815100,392,657 - 100,423,069 (-)NCBI
Sequence:
RefSeq Acc Id: NP_032758   ⟸   NM_008732
- Peptide Label: isoform 2
- UniProtKB: Q8CFA0 (UniProtKB/Swiss-Prot),   Q8BWV3 (UniProtKB/Swiss-Prot),   Q8BJL2 (UniProtKB/Swiss-Prot),   Q3UFV5 (UniProtKB/Swiss-Prot),   O54903 (UniProtKB/Swiss-Prot),   Q8VCU6 (UniProtKB/Swiss-Prot),   P49282 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001139633   ⟸   NM_001146161
- Peptide Label: isoform 1
- UniProtKB: P49282 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006520642   ⟸   XM_006520579
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006520641   ⟸   XM_006520578
- Peptide Label: isoform X2
- UniProtKB: Q8CFA0 (UniProtKB/Swiss-Prot),   Q8BWV3 (UniProtKB/Swiss-Prot),   Q8BJL2 (UniProtKB/Swiss-Prot),   Q3UFV5 (UniProtKB/Swiss-Prot),   O54903 (UniProtKB/Swiss-Prot),   Q8VCU6 (UniProtKB/Swiss-Prot),   P49282 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006520640   ⟸   XM_006520577
- Peptide Label: isoform X2
- UniProtKB: Q8CFA0 (UniProtKB/Swiss-Prot),   Q8BWV3 (UniProtKB/Swiss-Prot),   Q8BJL2 (UniProtKB/Swiss-Prot),   Q3UFV5 (UniProtKB/Swiss-Prot),   O54903 (UniProtKB/Swiss-Prot),   Q8VCU6 (UniProtKB/Swiss-Prot),   P49282 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006520643   ⟸   XM_006520580
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_011243789   ⟸   XM_011245487
- Peptide Label: isoform X1
- UniProtKB: P49282 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030104242   ⟸   XM_030248382
- Peptide Label: isoform X5
RefSeq Acc Id: XP_030104243   ⟸   XM_030248383
- Peptide Label: isoform X6
RefSeq Acc Id: XP_030104241   ⟸   XM_030248381
- Peptide Label: isoform X4
RefSeq Acc Id: NP_001343881   ⟸   NM_001356952
- Peptide Label: isoform 3
RefSeq Acc Id: ENSMUSP00000114702   ⟸   ENSMUST00000124324
RefSeq Acc Id: ENSMUSP00000116463   ⟸   ENSMUST00000138843
RefSeq Acc Id: ENSMUSP00000115357   ⟸   ENSMUST00000154331
RefSeq Acc Id: ENSMUSP00000115019   ⟸   ENSMUST00000154676
RefSeq Acc Id: ENSMUSP00000119056   ⟸   ENSMUST00000123461
RefSeq Acc Id: ENSMUSP00000115283   ⟸   ENSMUST00000136168
RefSeq Acc Id: ENSMUSP00000023774   ⟸   ENSMUST00000023774

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49282-F1-model_v2 AlphaFold P49282 1-568 view protein structure

Promoters
RGD ID:6826481
Promoter ID:MM_KWN:19734
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Lung
Transcripts:OTTMUST00000083406
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3615100,233,436 - 100,234,687 (-)MPROMDB
RGD ID:6826484
Promoter ID:MM_KWN:19735
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney
Transcripts:OTTMUST00000083405
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3615100,242,286 - 100,243,422 (-)MPROMDB
RGD ID:6826479
Promoter ID:MM_KWN:19737
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   BoneMarrow_0Hour,   Brain,   Liver,   Spleen
Transcripts:OTTMUST00000083399,   OTTMUST00000083400,   OTTMUST00000083402
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3615100,253,181 - 100,253,681 (-)MPROMDB
RGD ID:6826298
Promoter ID:MM_KWN:19738
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Lung
Transcripts:ENSMUST00000074905,   OTTMUST00000083404,   UC007XRE.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3615100,254,381 - 100,254,881 (-)MPROMDB
RGD ID:8685048
Promoter ID:EPDNEW_M20554
Type:initiation region
Name:Slc11a2_1
Description:Mus musculus solute carrier family 11 (proton-coupled divalentmetal ion transporters), member 2 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M20556  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3815100,423,000 - 100,423,060EPDNEW
RGD ID:8685050
Promoter ID:EPDNEW_M20556
Type:multiple initiation site
Name:Slc11a2_2
Description:Mus musculus solute carrier family 11 (proton-coupled divalentmetal ion transporters), member 2 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M20554  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3815100,424,171 - 100,424,231EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1345279 AgrOrtholog
Ensembl Genes ENSMUSG00000023030 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000023774 ENTREZGENE
  ENSMUST00000023774.12 UniProtKB/Swiss-Prot
  ENSMUST00000123461.8 UniProtKB/TrEMBL
  ENSMUST00000124324.2 UniProtKB/TrEMBL
  ENSMUST00000136168.2 UniProtKB/TrEMBL
  ENSMUST00000138843 ENTREZGENE
  ENSMUST00000138843.8 UniProtKB/Swiss-Prot
  ENSMUST00000154331.2 UniProtKB/TrEMBL
  ENSMUST00000154676.2 UniProtKB/TrEMBL
InterPro NRAMP_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18174 UniProtKB/Swiss-Prot
MGD MGI:1345279 ENTREZGENE
NCBI Gene 18174 ENTREZGENE
PANTHER NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11706 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Nramp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc11a2 PhenoGen
PRINTS NATRESASSCMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3YXP3_MOUSE UniProtKB/TrEMBL
  D3Z0R6_MOUSE UniProtKB/TrEMBL
  D3Z314_MOUSE UniProtKB/TrEMBL
  D6RGP0_MOUSE UniProtKB/TrEMBL
  F6ZM31_MOUSE UniProtKB/TrEMBL
  NRAM2_MOUSE UniProtKB/Swiss-Prot
  O54903 ENTREZGENE
  P49282 ENTREZGENE
  Q3UFV5 ENTREZGENE
  Q8BJL2 ENTREZGENE
  Q8BWV3 ENTREZGENE
  Q8CFA0 ENTREZGENE
  Q8VCU6 ENTREZGENE
UniProt Secondary O54903 UniProtKB/Swiss-Prot
  Q3UFV5 UniProtKB/Swiss-Prot
  Q8BJL2 UniProtKB/Swiss-Prot
  Q8BWV3 UniProtKB/Swiss-Prot
  Q8CFA0 UniProtKB/Swiss-Prot
  Q8VCU6 UniProtKB/Swiss-Prot