Ednra (endothelin receptor type A) - Rat Genome Database

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Gene: Ednra (endothelin receptor type A) Mus musculus
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Symbol: Ednra
Name: endothelin receptor type A
RGD ID: 737538
MGI Page MGI
Description: Enables endothelin receptor activity. Involved in several processes, including cellular response to gonadotropin stimulus; circulatory system development; and neuron differentiation. Acts upstream of or within several processes, including adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; neural crest cell development; and regulation of D-glucose transmembrane transport. Is active in plasma membrane. Is expressed in several structures, including alimentary system; branchial arch; cardiovascular system; central nervous system; and genitourinary system. Used to study mandibulofacial dysostosis with alopecia and velocardiofacial syndrome. Human ortholog(s) of this gene implicated in hypertension (multiple); lung disease; mandibulofacial dysostosis with alopecia; migraine; and obstructive sleep apnea. Orthologous to human EDNRA (endothelin receptor type A).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AEA0; AEA001; endothelin A receptor; endothelin-1 receptor; ET; ET-; ET-A; ET-AR; ETa; G-protein coupled receptor 10; Gpcr; Gpcr10; Mhdaa; Mhdaaea1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39878,389,658 - 78,451,081 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl878,389,660 - 78,451,093 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38877,663,029 - 77,724,452 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl877,663,031 - 77,724,464 (-)Ensemblmm10GRCm38
MGSCv37880,186,928 - 80,248,351 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36880,559,140 - 80,620,420 (-)NCBIMGSCv36mm8
Celera881,946,457 - 82,007,225 (-)NCBICelera
Cytogenetic Map8C1NCBI
cM Map836.63NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-noradrenaline  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
11-deoxycorticosterone  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-naphthylamine  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acadesine  (ISO)
acetamide  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
agmatine  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
ambrisentan  (ISO)
aminoguanidine  (ISO)
amitrole  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
apocynin  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
aspartame  (ISO)
atorvastatin calcium  (ISO)
atrasentan  (EXP,ISO)
atrazine  (ISO)
Azoxymethane  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bosentan  (ISO)
BQ 123  (EXP,ISO)
BQ 485  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cantharidin  (EXP)
carbon nanotube  (EXP,ISO)
carmustine  (ISO)
celecoxib  (ISO)
CGS-21680  (EXP)
chromium(6+)  (EXP)
cisplatin  (EXP,ISO)
cocaine  (ISO)
Cuprizon  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
daunorubicin  (ISO)
decabromodiphenyl ether  (ISO)
Deoxycorticosterone acetate  (ISO)
dexamethasone  (EXP)
dextran sulfate  (EXP)
dibutyl phthalate  (EXP,ISO)
diethyl malate  (EXP)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
enrasentan  (ISO)
ethanol  (EXP)
fenvalerate  (ISO)
fluvastatin  (ISO)
folic acid  (EXP)
fructose  (ISO)
fulvestrant  (ISO)
furan  (ISO)
glucose  (ISO)
hexadecanoic acid  (ISO)
hydrogen cyanide  (EXP)
inulin  (EXP)
isoprenaline  (EXP,ISO)
isoquinoline-1,5-diol  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
losartan  (EXP,ISO)
Magnolol  (ISO)
methimazole  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mifepristone  (ISO)
monocrotaline  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
nicotine  (ISO)
nitrofen  (EXP,ISO)
Nutlin-3  (ISO)
okadaic acid  (ISO)
ouabain  (ISO)
oxybenzone  (EXP)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phosphoramidon  (ISO)
pirinixic acid  (EXP)
potassium chloride  (EXP)
potassium cyanide  (EXP)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
Ptaquiloside  (EXP)
quartz  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
rebaudioside A  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium chloride  (EXP,ISO)
sparsentan  (EXP)
steviol  (ISO)
stevioside  (ISO)
sulfadimethoxine  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
superoxide  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
telmisartan  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (IGI)
angiogenesis  (IGI)
aorta development  (IMP)
artery smooth muscle contraction  (IEA,ISO)
atrial cardiac muscle tissue development  (IMP)
axon extension  (IMP)
axon guidance  (IMP)
axonogenesis involved in innervation  (IMP)
blood circulation  (IEA)
blood vessel remodeling  (IMP)
branching involved in blood vessel morphogenesis  (IGI,IMP)
calcium ion transmembrane transport  (IDA,IGI,IMP)
cAMP/PKA signal transduction  (IEA,ISO)
canonical Wnt signaling pathway  (IGI)
cardiac chamber formation  (IMP)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (IMP)
cellular response to follicle-stimulating hormone stimulus  (IDA)
cellular response to human chorionic gonadotropin stimulus  (IDA,IMP)
cellular response to hydrogen peroxide  (ISO)
cellular response to luteinizing hormone stimulus  (IDA)
cellular response to mechanical stimulus  (ISO)
cellular response to oxidative stress  (IMP)
cellular response to toxic substance  (IDA,IMP,ISO)
cranial skeletal system development  (IDA,IMP)
developmental pigmentation  (IBA)
embryonic heart tube development  (IGI,IMP)
embryonic skeletal system development  (IGI)
endothelin receptor signaling pathway  (IBA,IGI,IMP)
enteric nervous system development  (IEA)
establishment of endothelial barrier  (IDA,IEA)
face development  (IDA,IMP)
fibroblast proliferation  (ISO)
G protein-coupled receptor signaling pathway  (IEA,TAS)
gene expression  (IGI,IMP)
glomerular endothelium development  (IDA)
glomerular filtration  (IDA,ISO)
glomerulus development  (IMP)
head development  (IMP)
heart development  (IGI,IMP)
heart process  (IMP)
heparin proteoglycan metabolic process  (IEA,IGI)
histamine secretion  (ISO)
in utero embryonic development  (IMP)
intracellular calcium ion homeostasis  (IEA,IMP,ISO)
left ventricular cardiac muscle tissue morphogenesis  (IMP)
maternal process involved in parturition  (ISO)
meiotic cell cycle process involved in oocyte maturation  (IMP)
mesenchymal cell apoptotic process  (IMP)
middle ear morphogenesis  (IMP)
mitochondrion organization  (IDA)
mitotic cell cycle  (IMP)
negative regulation of apoptotic process  (ISO)
neural crest cell development  (IMP)
neural crest cell differentiation  (IGI,IMP)
neural crest cell fate commitment  (IMP)
neuromuscular process  (IMP)
neuron projection development  (IMP)
neuron remodeling  (IMP)
noradrenergic neuron differentiation  (IMP)
norepinephrine metabolic process  (IMP)
pharyngeal arch artery morphogenesis  (IMP)
phospholipase C-activating G protein-coupled receptor signaling pathway  (ISO)
podocyte apoptotic process  (IMP)
podocyte differentiation  (IDA,IEA,IGI)
positive regulation of calcium ion transport  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA)
positive regulation of cation channel activity  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of kidney development  (ISO)
positive regulation of neutrophil chemotaxis  (ISO)
positive regulation of odontogenesis  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of release of sequestered calcium ion into cytosol  (ISO)
protein phosphorylation  (IMP)
protein transmembrane transport  (IDA,IEA)
regulation of blood pressure  (IEA,IGI,IMP)
regulation of D-glucose transmembrane transport  (IDA)
regulation of epithelial cell proliferation  (ISO)
regulation of heart rate  (IGI,IMP)
regulation of protein localization to cell leading edge  (IMP)
renal albumin absorption  (IDA,IEA,IGI,IMP)
renal sodium ion absorption  (IEA,IMP)
respiratory gaseous exchange by respiratory system  (IMP)
response to acetylcholine  (IMP)
response to amphetamine  (IMP)
response to hypoxia  (IMP)
response to lipopolysaccharide  (ISO)
response to wounding  (IMP)
Rho protein signal transduction  (ISO)
semaphorin-plexin signaling pathway  (IMP)
signal transduction  (IEA)
smooth muscle cell proliferation  (ISO)
sodium ion homeostasis  (IEA,IGI)
sympathetic nervous system development  (IMP)
sympathetic neuron axon guidance  (IGI)
thyroid gland development  (IMP)
vascular associated smooth muscle cell development  (IMP)
vasoconstriction  (IBA,IEA,IMP,ISO)

Cellular Component
membrane  (IEA)
nuclear membrane  (ISO)
plasma membrane  (IBA,IDA,IEA)
T-tubule  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
aberrant origin of the right subclavian artery  (IAGP)
abnormal alisphenoid bone morphology  (IAGP)
abnormal alveolar process morphology  (IAGP)
abnormal artery morphology  (IAGP)
abnormal ascending aorta morphology  (IAGP)
abnormal basisphenoid bone morphology  (IAGP)
abnormal cardiovascular system morphology  (IAGP)
abnormal carotid artery morphology  (IAGP)
abnormal craniofacial bone morphology  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal dorsal aorta morphology  (IAGP)
abnormal ear shape  (IAGP)
abnormal facial morphology  (IEA)
abnormal facial nerve morphology  (IAGP)
abnormal first pharyngeal arch morphology  (IAGP)
abnormal fourth pharyngeal arch artery morphology  (IAGP)
abnormal gonial bone morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal hyoid bone morphology  (IAGP)
abnormal incisor morphology  (IAGP)
abnormal incudomalleolar joint morphology  (IAGP)
abnormal incus morphology  (IAGP)
abnormal inspiratory capacity  (IAGP)
abnormal jaw morphology  (IAGP)
abnormal malleus morphology  (IAGP)
abnormal mandible morphology  (IAGP)
abnormal mandibular condyloid process morphology  (IAGP)
abnormal mandibular nerve branching  (IAGP)
abnormal mandibular nerve morphology  (IAGP)
abnormal mandibular ramus morphology  (IAGP)
abnormal masseter muscle morphology  (IAGP)
abnormal maxilla morphology  (IAGP)
abnormal Meckel's cartilage morphology  (IAGP)
abnormal middle ear ossicle morphology  (IAGP)
abnormal mouth floor morphology  (IAGP)
abnormal mouth morphology  (IAGP)
abnormal muscle morphology  (IAGP)
abnormal orbit morphology  (IAGP)
abnormal outer ear helix morphology  (IAGP)
abnormal outer ear morphology  (IAGP)
abnormal palate morphology  (IAGP)
abnormal palatine bone morphology  (IAGP)
abnormal pharyngeal arch artery morphology  (IAGP)
abnormal pterygoid process morphology  (IAGP)
abnormal pulmonary ventilation  (IAGP)
abnormal respiration  (IAGP)
abnormal sixth pharyngeal arch artery morphology  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal sphenoid bone morphology  (IAGP)
abnormal stapes morphology  (IAGP)
abnormal styloid process morphology  (IAGP)
abnormal temporal bone morphology  (IAGP)
abnormal temporal bone petrous part morphology  (IAGP)
abnormal temporal bone squamous part morphology  (IAGP)
abnormal temporal bone zygomatic process morphology  (IAGP)
abnormal temporomandibular joint morphology  (IAGP)
abnormal third pharyngeal arch artery morphology  (IAGP)
abnormal trigeminal nerve morphology  (IAGP)
abnormal urine osmolality  (IAGP)
abnormal vital capacity  (IAGP)
abnormal zygomatic arch morphology  (IAGP)
abnormal zygomatic bone morphology  (IAGP)
absent gonial bone  (IAGP)
absent incus  (IAGP)
absent incus short process  (IAGP)
absent malleus  (IAGP)
absent Meckel's cartilage  (IAGP)
absent right subclavian artery  (IAGP)
absent salivary gland  (IAGP)
absent stapes  (IAGP)
absent submandibular gland  (IAGP)
absent temporal bone squamous part  (IAGP)
absent temporal bone zygomatic process  (IAGP)
absent tubotympanic recess  (IAGP)
absent tympanic membrane  (IAGP)
absent tympanic ring  (IAGP)
absent vibrissae  (IAGP)
anteriorly rotated ears  (IAGP)
aorta tubular hypoplasia  (IAGP)
cataract  (IEA)
cleft chin  (IAGP)
conductive hearing loss  (IAGP)
d-loop transposition of the great arteries  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased lung compliance  (IAGP)
decreased prepulse inhibition  (IAGP)
decreased startle reflex  (IAGP)
decreased total lung capacity  (IAGP)
dilated heart atrium  (IAGP)
double aortic arch  (IAGP)
double outlet right ventricle  (IAGP)
ectopic thymus  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
eyelids open at birth  (IAGP)
facial cleft  (IAGP)
impaired hearing  (IAGP)
increased circulating antidiuretic hormone level  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
incudomalleolar fusion  (IAGP)
interrupted aorta  (IAGP)
lower jaw to upper jaw transformation  (IAGP)
lowered ear position  (IAGP)
macrophthalmia  (IAGP)
malocclusion  (IAGP)
mandible hypoplasia  (IAGP)
micrognathia  (IAGP)
no abnormal phenotype detected  (IAGP)
overriding aortic valve  (IAGP)
patent ductus arteriosus  (IAGP)
pericardial edema  (IAGP)
pericardial effusion  (IAGP)
perimembraneous ventricular septal defect  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
persistent right 6th pharyngeal arch artery  (IAGP)
persistent right dorsal aorta  (IAGP)
persistent truncus arteriosus  (IAGP)
prenatal lethality  (IAGP)
preweaning lethality, complete penetrance  (IEA)
prominent cheeks  (IAGP)
round face  (IAGP)
round orbits  (IAGP)
short mandible  (IAGP)
short mandibular coronoid process  (IAGP)
short snout  (IAGP)
short styloid process  (IAGP)
shortened head  (IAGP)
small mandibular condyloid process  (IAGP)
small second pharyngeal arch  (IAGP)
small zygomatic bone  (IAGP)
thymus hypoplasia  (IAGP)
tongue hypoplasia  (IAGP)
upper jaw to lower jaw transformation  (IAGP)
wide coronal suture  (IAGP)
wide lambdoid suture  (IAGP)
wide sagittal suture  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Inhibition of endothelin-1 receptors improves impaired nitric oxide synthase-dependent dilation of cerebral arterioles in type-1 diabetic rats. Arrick DM and Mayhan WG, Microcirculation. 2010 Aug;17(6):439-46.
2. Major role for hypoxia inducible factor-1 and the endothelin system in promoting myocardial infarction and hypertension in an animal model of obstructive sleep apnea. Belaidi E, etal., J Am Coll Cardiol. 2009 Apr 14;53(15):1309-17.
3. Association of EDNRA, but not WNK4 or FKBP1B, polymorphisms with essential hypertension. Benjafield AV, etal., Clin Genet. 2003 Nov;64(5):433-8.
4. Endothelin-1 receptor subtypes expression and binding in a perfused rat model of myocardial infarction. Bikhazi AB, etal., Comp Biochem Physiol C Toxicol Pharmacol. 2003 Jan;134(1):35-43.
5. Genetic polymorphisms in endothelin-receptor-subtype-a-gene as susceptibility factor for obstructive sleep apnea syndrome. Buck D, etal., Sleep Med. 2010 Feb;11(2):213-7. Epub 2010 Jan 18.
6. Increased ET-1 and reduced ET(B) receptor expression in uremic hypertensive rats. D'Amours M, etal., Clin Exp Hypertens. 2010 Jan;32(1):61-9.
7. EDNRA variants associate with smooth muscle mRNA levels, cell proliferation rates, and cystic fibrosis pulmonary disease severity. Darrah R, etal., Physiol Genomics. 2010 Mar 3;41(1):71-7. Epub 2009 Dec 22.
8. Increased endothelin-1 reactivity and endothelial dysfunction in carotid arteries from rats with hyperhomocysteinemia. de Andrade CR, etal., Br J Pharmacol. 2009 Jun;157(4):568-80. Epub 2009 Apr 9.
9. Enhanced expression of renal endothelin-converting enzyme-1 and endothelin-A-receptor mRNA in rats with interstitial fibrosis following ureter ligation. Feldman DL, etal., J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S255-9.
10. Ambrisentan for the treatment of pulmonary arterial hypertension: results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2. Galie N, etal., Circulation. 2008 Jun 10;117(23):3010-9. Epub 2008 May 27.
11. Polymorphisms in genes of the endothelin system and cerebral small-vessel disease. Gormley K, etal., Stroke. 2005 Aug;36(8):1656-60. Epub 2005 Jul 7.
12. A polymorphism in the endothelin-A receptor gene predicts survival in patients with idiopathic dilated cardiomyopathy. Herrmann S, etal., Eur Heart J. 2001 Oct;22(20):1948-53.
13. Regulation of endothelin-converting enzyme 1 in nephrotic syndrome in rats. Ikebe M, etal., Nephron Exp Nephrol. 2003;94(4):e137-45.
14. The role of ET(A) and ET(B) receptor antagonists in acute and allergic inflammation in mice. Kassuya CA, etal., Peptides. 2008 Aug;29(8):1329-37. Epub 2008 Mar 16.
15. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
16. Peripheral mechanisms of erectile dysfunction in a rat model of chronic cocaine use. Kendirci M, etal., Eur Urol. 2007 Aug;52(2):555-63. Epub 2007 Mar 20.
17. Involvement of NO and MEK/ERK pathway in enhancement of endothelin-1-induced mesenteric artery contraction in later-stage type 2 diabetic Goto-Kakizaki rat. Matsumoto T, etal., Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1388-97. Epub 2009 Mar 13.
18. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
19. MGDs mouse GO annotations MGD data from the GO Consortium
20. MGD IEA MGD IEA
21. Inhibitory effects of PPAR-gamma on endothelin-1-induced inflammatory pathways in vascular smooth muscle cells from normotensive and hypertensive rats. Montezano AC, etal., J Am Soc Hypertens. 2007 Mar-Apr;1(2):150-60.
22. Polymorphisms of the endothelin-A and -B receptor genes in relation to blood pressure and myocardial infarction: the Etude Cas-Temoins sur l'Infarctus du Myocarde (ECTIM) Study. Nicaud V, etal., Am J Hypertens. 1999 Mar;12(3):304-10.
23. Roles of endothelin ETA and ETB receptors in the pathogenesis of monocrotaline-induced pulmonary hypertension. Nishida M, etal., J Cardiovasc Pharmacol. 2004 Aug;44(2):187-91.
24. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
25. Endothelin-1 (ET-1) is increased in rat retina after crushing optic nerve. Oku H, etal., Curr Eye Res. 2008 Jul;33(7):611-20.
26. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
27. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
28. ETA and ETB receptor function in pancreatitis-associated microcirculatory failure, inflammation, and parenchymal injury. Plusczyk T, etal., Am J Physiol Gastrointest Liver Physiol. 2003 Jul;285(1):G145-53.
29. Mouse MP Annotation Import Pipeline RGD automated import pipeline
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Endothelin, PAF and thromboxane A2 in allergic pulmonary hyperreactivity in mice. Richter M, etal., Prostaglandins Leukot Essent Fatty Acids. 2007 May;76(5):299-308. Epub 2007 Apr 19.
32. Tumor endothelin-1 enhances metastatic colonization of the lung in mouse xenograft models of bladder cancer. Said N, etal., J Clin Invest. 2011 Jan 4;121(1):132-47. doi: 10.1172/JCI42912. Epub 2010 Dec 22.
33. Endothelin receptor A-specific stimulation of glomerular inflammation and injury in a streptozotocin-induced rat model of diabetes. Saleh MA, etal., Diabetologia. 2010 Dec 30.
34. Effects of endothelin ETA receptor antagonism on granulocyte and lymphocyte accumulation in LPS-induced inflammation. Sampaio AL, etal., J Leukoc Biol. 2004 Jul;76(1):210-6. Epub 2004 Apr 23.
35. Cooperative effect of angiotensin AT(1) and endothelin ET(A) receptor antagonism limits the brain damage after ischemic stroke in rat. Stenman E, etal., Eur J Pharmacol. 2007 Sep 10;570(1-3):142-8. Epub 2007 Jun 9.
36. BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertension. Talati M, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Sep;299(3):L363-73. Epub 2010 Jun 18.
37. Role of endogenous endothelin-1 in post-ischemic cardiac dysfunction and norepinephrine overflow in rat hearts. Tawa M, etal., Eur J Pharmacol. 2008 Sep 4;591(1-3):182-8. Epub 2008 Jun 14.
38. Association between migraine and endothelin type A receptor (ETA -231 A/G) gene polymorphism. Tzourio C, etal., Neurology 2001 May 22;56(10):1273-7.
39. Ischemic heart disease induces upregulation of endothelin receptor mRNA in human coronary arteries. Wackenfors A, etal., Eur J Pharmacol. 2004 Jan 19;484(1):103-9.
40. Endothelin-1 regulates proliferative responses, both alone and synergistically with PDGF, in rat tracheal smooth muscle cells. Yahiaoui L, etal., Cell Physiol Biochem. 2006;17(1-2):37-46. Epub 2006 Feb 7.
41. Inhibition of endothelin-1 and hypoxia-induced pulmonary pressor responses in the rat by a novel selective endothelin-A receptor antagonist, di-n-butylaminocarbamyl-L-leucyl-D-tryptophanyl-D-4-chloro-Phe. Yan LD, etal., J Cardiovasc Pharmacol. 2010 Sep;56(3):246-54.
42. Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene. Yanagisawa H, etal., Development 1998 Mar;125(5):825-36.
43. Role of Endothelin-1/Endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice. Yanagisawa H, etal., J Clin Invest 1998 Jul 1;102(1):22-33.
44. [Effect and mechanism of salvianolic acid B in attenuating elevated portal pressure in a rat model of portal hypertension induced by endothelin-1]. Zhou Y, etal., Zhong Xi Yi Jie He Xue Bao. 2007 Jan;5(1):61-4.
Additional References at PubMed
PMID:7904485   PMID:8288218   PMID:8548579   PMID:8587354   PMID:9012511   PMID:9449664   PMID:9495516   PMID:9826706   PMID:10194519   PMID:10198387   PMID:10349636   PMID:10479458  
PMID:10625532   PMID:10626068   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11546805   PMID:11688556   PMID:12413905   PMID:12477932   PMID:12763050   PMID:14585980   PMID:14659802  
PMID:14691545   PMID:15226263   PMID:15239958   PMID:15306564   PMID:15327783   PMID:15489334   PMID:15647918   PMID:15664398   PMID:15838254   PMID:15838300   PMID:15838311   PMID:15838332  
PMID:15838353   PMID:15928212   PMID:16141072   PMID:16141073   PMID:16399858   PMID:16602821   PMID:16868309   PMID:16962346   PMID:16984730   PMID:17294360   PMID:17607529   PMID:17616694  
PMID:17660396   PMID:18199583   PMID:18287559   PMID:18401410   PMID:18480165   PMID:18524860   PMID:18635823   PMID:18703610   PMID:18784261   PMID:19017795   PMID:19111534   PMID:19185569  
PMID:19193724   PMID:19213955   PMID:19299580   PMID:19370413   PMID:19879049   PMID:19943105   PMID:20093323   PMID:20357223   PMID:20516397   PMID:20628431   PMID:20929948   PMID:21218036  
PMID:21237142   PMID:21555149   PMID:21565284   PMID:21873635   PMID:21918182   PMID:21949113   PMID:22287612   PMID:22354888   PMID:22442497   PMID:22483687   PMID:22681550   PMID:23217151  
PMID:23592430   PMID:23698114   PMID:23933587   PMID:24043815   PMID:24194600   PMID:24371298   PMID:24412386   PMID:24722437   PMID:24756152   PMID:24875861   PMID:25050930   PMID:25181417  
PMID:25197047   PMID:25572710   PMID:25772936   PMID:25889273   PMID:25902370   PMID:26089164   PMID:26506449   PMID:26531127   PMID:26637970   PMID:27026367   PMID:27165837   PMID:27671791  
PMID:27778057   PMID:27899487   PMID:28455376   PMID:29272493   PMID:29545351   PMID:29570803   PMID:30031229   PMID:30384975   PMID:30735130   PMID:30905259   PMID:30990108   PMID:31219639  
PMID:31402170   PMID:31923844   PMID:31924792   PMID:32133772   PMID:33416142   PMID:33443158   PMID:33457411   PMID:34716275   PMID:35429992   PMID:36637912   PMID:37963542   PMID:38355793  
PMID:39556044  


Genomics

Comparative Map Data
Ednra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39878,389,658 - 78,451,081 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl878,389,660 - 78,451,093 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38877,663,029 - 77,724,452 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl877,663,031 - 77,724,464 (-)Ensemblmm10GRCm38
MGSCv37880,186,928 - 80,248,351 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36880,559,140 - 80,620,420 (-)NCBIMGSCv36mm8
Celera881,946,457 - 82,007,225 (-)NCBICelera
Cytogenetic Map8C1NCBI
cM Map836.63NCBI
EDNRA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384147,481,097 - 147,544,954 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4147,480,917 - 147,544,954 (+)Ensemblhg38GRCh38
GRCh374148,402,249 - 148,466,106 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364148,621,575 - 148,685,555 (+)NCBIBuild 36Build 36hg18NCBI36
Build 344148,759,734 - 148,823,710NCBI
Celera4145,723,204 - 145,787,202 (+)NCBICelera
Cytogenetic Map4q31.22-q31.23NCBI
HuRef4144,129,326 - 144,193,179 (+)NCBIHuRef
CHM1_14148,380,418 - 148,444,465 (+)NCBICHM1_1
T2T-CHM13v2.04150,805,228 - 150,869,037 (+)NCBIT2T-CHM13v2.0
Ednra
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81947,137,360 - 47,207,961 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1947,137,771 - 47,201,284 (+)EnsemblGRCr8
mRatBN7.21930,233,540 - 30,303,727 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1930,233,571 - 30,297,049 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1937,065,939 - 37,130,121 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01937,719,814 - 37,783,991 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01939,968,901 - 40,033,091 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01933,928,356 - 33,991,703 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1933,928,356 - 33,991,703 (+)Ensemblrn6Rnor6.0
Rnor_5.01944,812,252 - 44,874,904 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41932,042,366 - 32,108,153 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1929,719,589 - 29,778,843 (+)NCBICelera
RGSC_v3.11932,051,058 - 32,110,066 (+)NCBI
Cytogenetic Map19q11NCBI
Ednra
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554283,062,303 - 3,114,761 (+)Ensembl
ChiLan1.0NW_0049554283,062,303 - 3,114,761 (+)NCBIChiLan1.0ChiLan1.0
EDNRA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23145,349,200 - 145,415,071 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14145,714,744 - 145,780,615 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04139,815,336 - 139,879,600 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14151,476,353 - 151,536,497 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4151,476,356 - 151,536,497 (+)EnsemblpanPan2panpan1.1
EDNRA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11545,823,472 - 45,878,527 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1545,823,560 - 45,876,463 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1546,219,878 - 46,270,714 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01546,496,528 - 46,553,179 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1546,496,502 - 46,554,470 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11545,768,959 - 45,819,737 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01545,864,678 - 45,915,481 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01546,175,034 - 46,225,816 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ednra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530144,512,782 - 44,568,451 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365351,949,941 - 2,005,910 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365351,950,117 - 2,005,786 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EDNRA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl881,209,327 - 81,276,853 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1881,210,750 - 81,279,053 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2886,293,177 - 86,319,721 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EDNRA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1793,980,983 - 94,043,863 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl793,985,797 - 94,042,296 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603773,678,428 - 73,748,330 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ednra
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248536,302,751 - 6,360,089 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248536,298,406 - 6,362,353 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ednra
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11722,389,030 - 22,442,843 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ednra
5510 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:936
Count of miRNA genes:520
Interacting mature miRNAs:654
Transcripts:ENSMUST00000034029, ENSMUST00000146561
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined866326836100326976Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83663015493455280Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84809006482090180Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84924559183245673Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85892810792928107Mouse
14746987Manh64_mmandible shape 64 (mouse)85050595884505958Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined876411976110412125Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined866084397100084549Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84809006482090180Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85474046188740637Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84819016882190288Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85515925889159407Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined871032003105032123Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined876411976110412125Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871740461124622354Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6418673698186736Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86466617698666325Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85050595884505958Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85913640493136404Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85629887290298872Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined876411976110412125Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined872122809106123021Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86872247983326976Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86151347995513605Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871829531105829637Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873929123107929226Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)84016229795416226Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7158942790929226Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85233484386334843Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined871032003105032123Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)874126628126826739Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71740461124622354Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84474791478748059Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined876402145110402251Mouse

Markers in Region
UniSTS:235933  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38877,664,302 - 77,664,562UniSTSGRCm38
MGSCv37880,188,201 - 80,188,461UniSTSGRCm37
Celera881,947,729 - 81,947,989UniSTS
Cytogenetic Map8C2UniSTS
UniSTS:235935  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38877,678,370 - 77,678,583UniSTSGRCm38
MGSCv37880,202,269 - 80,202,482UniSTSGRCm37
Celera881,961,854 - 81,962,067UniSTS
Cytogenetic Map8C2UniSTS
PMC262340P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38877,667,608 - 77,668,203UniSTSGRCm38
MGSCv37880,191,507 - 80,192,102UniSTSGRCm37
Celera881,951,069 - 81,951,664UniSTS
Cytogenetic Map8C2UniSTS
Ednra  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C2UniSTS
cM MapUN UniSTS
cM Map8 UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000034029   ⟹   ENSMUSP00000034029
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl878,389,660 - 78,451,065 (-)Ensembl
GRCm38.p6 Ensembl877,663,031 - 77,724,436 (-)Ensembl
Ensembl Acc Id: ENSMUST00000146561
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl878,396,323 - 78,451,093 (-)Ensembl
GRCm38.p6 Ensembl877,669,694 - 77,724,464 (-)Ensembl
RefSeq Acc Id: NM_010332   ⟹   NP_034462
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39878,389,658 - 78,451,081 (-)NCBI
GRCm38877,663,029 - 77,724,452 (-)ENTREZGENE
MGSCv37880,186,928 - 80,248,351 (-)RGD
Celera881,946,457 - 82,007,225 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_034462   ⟸   NM_010332
- Peptide Label: precursor
- UniProtKB: Q91VV2 (UniProtKB/Swiss-Prot),   Q61614 (UniProtKB/Swiss-Prot),   O54993 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000034029   ⟸   ENSMUST00000034029

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61614-F1-model_v2 AlphaFold Q61614 1-427 view protein structure

Promoters
RGD ID:8667527
Promoter ID:EPDNEW_M11795
Type:initiation region
Name:Ednra_1
Description:Mus musculus endothelin receptor type A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38877,724,467 - 77,724,527EPDNEW
RGD ID:6843059
Promoter ID:MM_KWN:54925
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   Lung,   MEF_B4,   Spleen
Transcripts:NM_010332,   OTTMUST00000059826
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36880,247,886 - 80,248,922 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:105923 AgrOrtholog
Ensembl Genes ENSMUSG00000031616 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000034029 ENTREZGENE
  ENSMUST00000034029.8 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro Endthln_rcpt UniProtKB/Swiss-Prot
  ETA_rcpt UniProtKB/Swiss-Prot
  GPCR_endothelin_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report mmu:13617 UniProtKB/Swiss-Prot
MGD MGI:105923 ENTREZGENE
NCBI Gene Ednra ENTREZGENE
PANTHER ENDOTHELIN-1 RECEPTOR UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Ednra PhenoGen
PRINTS ENDOTHELINAR UniProtKB/Swiss-Prot
  ENDOTHELINR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt EDNRA_MOUSE UniProtKB/Swiss-Prot
  O54993 ENTREZGENE
  Q61614 ENTREZGENE
  Q8BMW4_MOUSE UniProtKB/TrEMBL
  Q91VV2 ENTREZGENE
UniProt Secondary O54993 UniProtKB/Swiss-Prot
  Q91VV2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-07-28 Ednra  endothelin receptor type A  Gpcr10  G-protein coupled receptor 10  Symbol and/or name updated 27372883 PROVISIONAL
2025-07-22 Gpcr10  G-protein coupled receptor 10  Ednra  endothelin receptor type A  Symbol and/or name change 5135510 APPROVED
2024-08-21 Ednra  endothelin receptor type A  Gpcr10  G-protein coupled receptor 10  Symbol and/or name change 5135510 APPROVED
2024-08-21 Gpcr10  G-protein coupled receptor 10  Ednra  endothelin receptor type A  Symbol and/or name change 5135510 APPROVED