OPRM1 (opioid receptor mu 1) - Rat Genome Database

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Gene: OPRM1 (opioid receptor mu 1) Homo sapiens
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Symbol: OPRM1
Name: opioid receptor mu 1
RGD ID: 737513
HGNC Page HGNC:8156
Description: Enables G-protein alpha-subunit binding activity and beta-endorphin receptor activity. Involved in several processes, including behavioral response to ethanol; regulation of cAMP-mediated signaling; and regulation of nitric oxide biosynthetic process. Predicted to be located in axon; dendrite; and endosome. Predicted to be active in GABA-ergic synapse; spine apparatus; and synaptic membrane. Implicated in several diseases, including alcohol dependence; alcohol use disorder; drug dependence (multiple); drug psychosis; and withdrawal disorder (multiple). Biomarker of autism spectrum disorder; cocaine dependence; heroin dependence; opiate dependence; and opioid abuse.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: hMOP; KIAA0403; LMOR; M-OR-1; micro opioid receptor isoform hMOR-1A2; MOP; MOR; MOR1; mu opiate receptor; mu opioid receptor hMOR-1a; mu opioid receptor splice variant hMOR-1b; mu opioid receptor splice variant hMOR-1S; mu opioid receptor splice variant hMOR-1Y2; mu opioid receptor splice variant hMOR-1Y3; mu opioid receptor splice variant hMOR-1Z; mu-type opioid receptor; opioid receptor, mu 1; OPRM
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386154,010,496 - 154,246,867 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6154,010,496 - 154,246,867 (+)EnsemblGRCh38hg38GRCh38
GRCh376154,331,631 - 154,568,001 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366154,402,136 - 154,609,693 (+)NCBINCBI36Build 36hg18NCBI36
Build 346154,452,556 - 154,660,114NCBI
Celera6155,066,098 - 155,302,376 (+)NCBICelera
Cytogenetic Map6q25.2NCBI
HuRef6151,895,214 - 152,131,143 (+)NCBIHuRef
CHM1_16154,595,701 - 154,831,638 (+)NCBICHM1_1
T2T-CHM13v2.06155,212,511 - 155,448,859 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(3,4-dihydroxyphenyl)acetic acid  (ISO)
(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin  (EXP,ISO)
(R)-noradrenaline  (ISO)
(R,R)-tramadol  (ISO)
(S)-amphetamine  (ISO)
(S)-nicotine  (ISO)
1,1,1-trichloroethane  (ISO)
1,2-dichloroethane  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
3',5'-cyclic AMP  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
7-Benzylidenenaltrexone  (EXP)
7-Hydroxymitragynine  (EXP,ISO)
acetylmethadol  (ISO)
aflatoxin B1  (EXP)
Aflatoxin B2 alpha  (EXP)
alcohol  (ISO)
all-trans-retinoic acid  (EXP)
all-trans-retinol  (ISO)
alvimopan  (EXP)
ammonium chloride  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
Bardoxolone methyl  (EXP)
benzamide  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-Funaltrexamine  (ISO)
bisphenol A  (ISO)
buprenorphine  (EXP,ISO)
butan-1-ol  (ISO)
butorphanol  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
Calphostin C  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
carfentanil  (EXP)
carrageenan  (ISO)
CGP 52608  (EXP)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
cocaine  (EXP,ISO)
codeine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (EXP)
dextromethorphan  (ISO)
dextropropoxyphene  (ISO)
dextrorphan  (ISO)
diisopropyl fluorophosphate  (ISO)
dizocilpine maleate  (ISO)
DPDPE  (ISO)
dynorphin A  (EXP,ISO)
Endomorphin-1  (ISO)
Endomorphin-2  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
fentanyl  (EXP,ISO)
fluoxetine  (ISO)
furan  (ISO)
gamma-aminobutyric acid  (ISO)
genistein  (ISO)
GTP  (ISO)
guanosine 5'-[gamma-thio]triphosphate  (EXP,ISO)
haloperidol  (ISO)
homovanillic acid  (ISO)
hydrocodone  (ISO)
hydromorphone  (EXP,ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
Leu-enkephalin  (EXP)
Levallorphan  (ISO)
Levorphanol  (ISO)
lipopolysaccharide  (EXP)
lithium chloride  (ISO)
magnesium atom  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methadone  (ISO)
methamphetamine  (EXP,ISO)
methotrexate  (EXP)
methoxychlor  (ISO)
methylnaltrexone  (EXP)
Mitragynine  (EXP,ISO)
Morphiceptin  (ISO)
morphine  (EXP,ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
Nalmefene  (EXP)
naloxone  (EXP,ISO)
naltrexone  (EXP,ISO)
nicotine  (ISO)
Nonylphenol  (ISO)
oxycodone  (ISO)
Oxymorphone  (ISO)
paraquat  (EXP)
PCB138  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosphatidic acid  (ISO)
picrotoxin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
serotonin  (ISO)
sodium arsenite  (EXP)
sulfasalazine  (EXP)
tamoxifen  (EXP)
tapentadol  (EXP,ISO)
thioglycolic acid  (ISO)
tianeptine  (EXP)
titanium dioxide  (ISO)
tramadol  (ISO)
trichostatin A  (ISO)
U69593  (ISO)
valproic acid  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute inflammatory response to antigenic stimulus  (ISO)
adenylate cyclase-activating dopamine receptor signaling pathway  (ISO)
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway  (ISS)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (ISO)
adenylate cyclase-inhibiting opioid receptor signaling pathway  (ISO)
behavioral response to ethanol  (IMP)
calcium ion transmembrane transport  (IEA)
cellular response to morphine  (IEA)
eating behavior  (ISO)
estrous cycle  (ISO)
excitatory postsynaptic potential  (ISO)
G protein-coupled opioid receptor signaling pathway  (IBA,IEA,ISS)
G protein-coupled receptor signaling pathway  (IEA,ISO)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  (TAS)
locomotory behavior  (ISO)
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
negative regulation of cAMP-mediated signaling  (IDA)
negative regulation of cell population proliferation  (TAS)
negative regulation of cytosolic calcium ion concentration  (IDA)
negative regulation of luteinizing hormone secretion  (ISO)
negative regulation of nitric oxide biosynthetic process  (IDA)
negative regulation of Wnt protein secretion  (IMP)
neuropeptide signaling pathway  (IBA,IEA)
phospholipase C-activating G protein-coupled receptor signaling pathway  (ISS)
positive regulation of appetite  (ISO)
positive regulation of cAMP-mediated signaling  (IDA)
positive regulation of cytosolic calcium ion concentration  (IDA)
positive regulation of ERK1 and ERK2 cascade  (ISS)
positive regulation of gluconeogenesis  (ISO)
positive regulation of neurogenesis  (ISS)
positive regulation of nitric oxide biosynthetic process  (IDA)
presynaptic modulation of chemical synaptic transmission  (ISO)
regulation of cellular response to stress  (IMP)
regulation of NMDA receptor activity  (ISS)
response to cocaine  (ISO)
response to ethanol  (ISO)
response to food  (ISO)
response to growth factor  (ISO)
response to lipopolysaccharide  (ISO)
sensory perception  (NAS)
sensory perception of pain  (IBA,ISS)
social behavior  (ISO)
sperm ejaculation  (ISO)
transmission of nerve impulse  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (EXP)
bupivacaine pharmacodynamics pathway  (EXP)
buprenorphine pharmacodynamics pathway  (EXP)
chloroprocaine pharmacodynamics pathway  (EXP)
citalopram pharmacodynamics pathway  (EXP)
cocaine pharmacodynamics pathway  (EXP)
codeine and morphine pharmacodynamics pathway  (EXP)
codeine and morphine pharmacokinetics pathway  (EXP)
desipramine pharmacodynamics pathway  (EXP)
diphenoxylate pharmacodynamics pathway  (EXP)
escitalopram pharmacodynamics pathway  (EXP)
ethylmorphine pharmacodynamics pathway  (EXP)
fentanyl pharmacodynamics pathway  (EXP)
fluoxetine pharmacodynamics pathway  (EXP)
heroin pharmacodynamics pathway  (EXP)
heroin pharmacokinetics pathway  (EXP)
hydrocodone pharmacodynamics pathway  (EXP)
hydromorphone pharmacodynamics pathway  (EXP)
imipramine pharmacodynamics pathway  (EXP)
interleukin-4 signaling pathway  (EXP)
levacetylmethadol pharmacodynamics pathway  (EXP)
levobupivacaine phgarmacodynamics pathway  (EXP)
levorphanol pharmacodynamics pathway  (EXP)
lidocaine pharmacodynamics pathway  (EXP)
mepivacaine pharmacodynamics pathway  (EXP)
methadone pharmacodynamics pathway  (EXP)
methadone pharmacokinetics pathway  (EXP)
nalbuphine pharmacodynamics pathway  (EXP)
naloxone pharmacodynamics pathway  (EXP)
naltrexone pharmacodynamics pathway  (EXP)
nicotine pharmacodynamics pathway  (EXP)
oxybuprocaine pharmacodynamics pathway  (EXP)
oxycodone pharmacodynamics pathway  (EXP)
oxymorphone pharmacodynamics pathway  (EXP)
pentazocine pharmacodynamics pathway  (EXP)
prilocaine pharmacodynamics pathway  (EXP)
procaine pharmacodynamics pathway  (EXP)
remifentanil pharmacodynamics pathway  (EXP)
ropivacaine pharmacodynamics pathway  (EXP)
tramadol pharmacodynamics pathway  (EXP)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Cholestasis induced antinociception and decreased gene expression of MOR1 in rat brain. Ahmadi S, etal., Neuroscience. 2015 Jan 22;284:78-86. doi: 10.1016/j.neuroscience.2014.08.063. Epub 2014 Oct 5.
2. Genetic susceptibility of opioid receptor genes polymorphism to drug addiction: A candidate-gene association study. Al-Eitan LN, etal., BMC Psychiatry. 2021 Jan 5;21(1):5. doi: 10.1186/s12888-020-03006-z.
3. Mu opioid receptor (OPRM1) as a predictor of treatment outcome in opiate-dependent individuals of Arab descent. Al-Eitan LN, etal., Pharmgenomics Pers Med. 2012;5:99-111. doi: 10.2147/PGPM.S33351. Epub 2012 Sep 7.
4. Opioid and Dopamine Genes Interact to Predict Naltrexone Response in a Randomized Alcohol Use Disorder Clinical Trial. Anton RF, etal., Alcohol Clin Exp Res. 2020 Oct;44(10):2084-2096. doi: 10.1111/acer.14431. Epub 2020 Sep 19.
5. An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study. Anton RF, etal., Arch Gen Psychiatry. 2008 Feb;65(2):135-44. doi: 10.1001/archpsyc.65.2.135.
6. Incubation of neural alcohol cue reactivity after withdrawal and its blockade by naltrexone. Bach P, etal., Addict Biol. 2020 Jan;25(1):e12717. doi: 10.1111/adb.12717. Epub 2019 Feb 12.
7. Association of polymorphisms in pharmacogenetic candidate genes (OPRD1, GAL, ABCB1, OPRM1) with opioid dependence in European population: a case-control study. Beer B, etal., PLoS One. 2013 Sep 25;8(9):e75359. doi: 10.1371/journal.pone.0075359. eCollection 2013.
8. Mu opioid receptor gene variants: lack of association with alcohol dependence. Bergen AW, etal., Mol Psychiatry. 1997 Oct-Nov;2(6):490-4. doi: 10.1038/sj.mp.4000331.
9. Dysregulated expression of the alternatively spliced variant mRNAs of the mu opioid receptor gene, OPRM1, in the medial prefrontal cortex of male human heroin abusers and heroin self-administering male rats. Brown TG, etal., J Neurosci Res. 2022 Jan;100(1):35-47. doi: 10.1002/jnr.24640. Epub 2020 Jun 7.
10. Expression of the mu opioid receptor in the human immunodeficiency virus type 1 transgenic rat model. Chang SL, etal., J Virol. 2007 Aug;81(16):8406-11. Epub 2007 Jun 6.
11. Acute inflammation induces segmental, bilateral, supraspinally mediated opioid release in the rat spinal cord, as measured by mu-opioid receptor internalization. Chen W and Marvizon JC, Neuroscience. 2009 Jun 16;161(1):157-72. Epub 2009 Mar 17.
12. Role of toll-like receptor 4 antagonist Lipopolysaccharide-Rhodobacter sphaeroides on acute stress-induced voluntary ethanol preference and drinking behaviour: In vivo Swiss Albino mouse model. Chuang HG, etal., Eur Neuropsychopharmacol. 2021 Apr;45:59-72. doi: 10.1016/j.euroneuro.2019.12.121. Epub 2020 Feb 1.
13. A polymorphism in the OPRM1 3'-untranslated region is associated with methadone efficacy in treating opioid dependence. Crist RC, etal., Pharmacogenomics J. 2018 Jan;18(1):173-179. doi: 10.1038/tpj.2016.89. Epub 2016 Dec 13.
14. A genetic association study of the mu opioid receptor and severe opioid dependence. Crowley JJ, etal., Psychiatr Genet. 2003 Sep;13(3):169-73. doi: 10.1097/00041444-200309000-00006.
15. Opioid system genes in alcoholism: a case-control study in Croatian population. Cupic B, etal., Neuropeptides. 2013 Oct;47(5):315-9. doi: 10.1016/j.npep.2013.08.002. Epub 2013 Aug 28.
16. Elevated levels of DNA methylation at the OPRM1 promoter region in men with opioid use disorder. Ebrahimi G, etal., Am J Drug Alcohol Abuse. 2018;44(2):193-199. doi: 10.1080/00952990.2016.1275659. Epub 2017 Jan 25.
17. Decreased immunodensities of micro-opioid receptors, receptor kinases GRK 2/6 and beta-arrestin-2 in postmortem brains of opiate addicts. Ferrer-Alcón M, etal., Brain Res Mol Brain Res. 2004 Feb 5;121(1-2):114-22. doi: 10.1016/j.molbrainres.2003.11.009.
18. Ischemic insults promote epigenetic reprogramming of mu opioid receptor expression in hippocampal neurons. Formisano L, etal., Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4170-5. Epub 2007 Feb 28.
19. Association between Opioid Receptor mu 1 (OPRM1) Gene Polymorphisms and Tobacco and Alcohol Consumption in a Spanish Population. Francès F, etal., Bosn J Basic Med Sci. 2015 Apr 25;15(2):31-6. doi: 10.17305/bjbms.2015.243.
20. Nonreplication of association between mu-opioid-receptor gene (OPRM1) A118G polymorphism and substance dependence. Franke P, etal., Am J Med Genet. 2001 Jan 8;105(1):114-9.
21. Contribution of Genetic Polymorphisms and Haplotypes in DRD2, BDNF, and Opioid Receptors to Heroin Dependence and Endophenotypes Among the Han Chinese. Gao X, etal., OMICS. 2017 Jul;21(7):404-412. doi: 10.1089/omi.2017.0057.
22.  Role of µ-Opioid Receptor Polymorphism in Patients of Rheumatoid Arthritis and their Correlation with Severity of Disease. Gauri L, etal., J Assoc Physicians India. 2019 Apr;67(4):22-25.
23. Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study. Gelernter J, etal., Alcohol Clin Exp Res. 2007 Apr;31(4):555-63. doi: 10.1111/j.1530-0277.2007.00339.x.
24. Association Study of OPRM1 Gene in a Sample of Schizophrenia Patients With Alcohol Dependence or Abuse. Gendy MNS, etal., Can J Addict. 2019 Dec;10(4):30-34. doi: 10.1097/cxa.0000000000000069.
25. The expression of opioid genes in non-classical reward areas depends on early life conditions and ethanol intake. Granholm L, etal., Brain Res. 2017 Aug 1;1668:36-45. doi: 10.1016/j.brainres.2017.05.006. Epub 2017 May 13.
26. μ-Opioid and dopamine-D2 receptor expression in the nucleus accumbens of male Sprague-Dawley rats whose sucrose consumption, but not preference, decreases after nerve injury. Hakim JD, etal., Behav Brain Res. 2020 Mar 2;381:112416. doi: 10.1016/j.bbr.2019.112416. Epub 2019 Dec 10.
27. Nicotine withdrawal sensitivity, linkage to chr6q26, and association of OPRM1 SNPs in the SMOking in FAMilies (SMOFAM) sample. Hardin J, etal., Cancer Epidemiol Biomarkers Prev. 2009 Dec;18(12):3399-406. doi: 10.1158/1055-9965.EPI-09-0960.
28. Spinal pharmacology of antinociception produced by microinjection of mu or delta opioid receptor agonists in the ventromedial medulla of the rat. Hurley RW, etal., Neuroscience. 2003;118(3):789-96.
29. Linkage disequilibrium and association with methamphetamine dependence/psychosis of mu-opioid receptor gene polymorphisms. Ide S, etal., Pharmacogenomics J. 2006 May-Jun;6(3):179-88. doi: 10.1038/sj.tpj.6500355.
30. Searching for evidence of genetic mediation of opioid withdrawal by opioid receptor gene polymorphisms. Jones JD, etal., Am J Addict. 2016 Jan;25(1):41-8. doi: 10.1111/ajad.12316. Epub 2015 Dec 21.
31. A118g polymorphism in mu opioid receptor gene (oprm1): association with opiate addiction in subjects of Indian origin. Kapur S, etal., J Integr Neurosci. 2007 Dec;6(4):511-22. doi: 10.1142/s0219635207001635.
32. OPRD1 rs569356 polymorphism has an effect on plasma norbuprenorphine levels and dose/kg-normalized norbuprenorphine values in individuals with opioid use disorder. Kaya-Akyüzlü D, etal., Environ Toxicol Pharmacol. 2023 Jun;100:104143. doi: 10.1016/j.etap.2023.104143. Epub 2023 May 3.
33. Gender differences in the genetic risk for alcohol dependence--the results of a pharmacogenetic study in Korean alcoholics. Kim SG, Nihon Arukoru Yakubutsu Igakkai Zasshi. 2009 Dec;44(6):680-5.
34. The contribution of MOR-1 exons 1-4 to morphine and heroin analgesia and dependence. Klein G, etal., Neurosci Lett. 2009 Jul 3;457(3):115-9. doi: 10.1016/j.neulet.2009.04.012. Epub 2009 Apr 9.
35. A single nucleotide polymorphism in OPRM1(rs483481) and risk for heroin use disorder. Koijam AS, etal., J Addict Dis. 2020 Apr-Jun;38(2):214-222. doi: 10.1080/10550887.2020.1740070. Epub 2020 Mar 19.
36. Morphine withdrawal precipitated by specific mu, delta or kappa opioid receptor antagonists: a c-Fos protein study in the rat central nervous system. Le Guen S, etal., Eur J Neurosci. 2003 Jun;17(11):2425-37. doi: 10.1046/j.1460-9568.2003.02678.x.
37. Morphine-6beta-glucuronide-induced hyperphagia: characterization of opioid action by selective antagonists and antisense mapping in rats. Leventhal L, etal., J Pharmacol Exp Ther. 1998 Nov;287(2):538-44.
38. The μ-opioid receptor nonsynonymous variant 118A>G is associated with prolonged abstinence from heroin without agonist treatment. Levran O, etal., Pharmacogenomics. 2017 Oct;18(15):1387-1391. doi: 10.2217/pgs-2017-0092. Epub 2017 Oct 4.
39. Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European-Americans. Luo X, etal., Am J Med Genet B Neuropsychiatr Genet. 2003 Jul 1;120B(1):97-108. doi: 10.1002/ajmg.b.20034.
40. Induction of hyperphagia and carbohydrate intake by μ-opioid receptor stimulation in circumscribed regions of frontal cortex. Mena JD, etal., J Neurosci. 2011 Mar 2;31(9):3249-60. doi: 10.1523/JNEUROSCI.2050-10.2011.
41. Ethnicity-dependent effect of rs1799971 polymorphism on OPRM1 expression in the postmortem brain and responsiveness to antipsychotics. Miyahara K, etal., J Psychiatr Res. 2023 Oct;166:10-16. doi: 10.1016/j.jpsychires.2023.08.007. Epub 2023 Aug 28.
42. OPRM1 influence on and effectiveness of an individualized treatment plan for prescription opioid use disorder patients. Muriel J, etal., Ann N Y Acad Sci. 2018 Aug;1425(1):82-93. doi: 10.1111/nyas.13735. Epub 2018 May 20.
43. Association of mu-opioid receptor gene polymorphism A118G with alcohol dependence in a Japanese population. Nishizawa D, etal., Neuropsychobiology. 2006;53(3):137-41. doi: 10.1159/000093099. Epub 2006 May 4.
44. OPRM1 and diagnosis-related posttraumatic stress disorder in binge-drinking patients living with HIV. Nugent NR, etal., AIDS Behav. 2012 Nov;16(8):2171-80. doi: 10.1007/s10461-011-0095-8.
45. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
46. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
47. Preclinical and Clinical Evidence for a Distinct Regulation of Mu Opioid and Type 1 Cannabinoid Receptor Genes Expression in Obesity. Pucci M, etal., Front Genet. 2019 Jun 14;10:523. doi: 10.3389/fgene.2019.00523. eCollection 2019.
48. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
49. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
50. Altered Global mRNA Expressions of Pain and Aggression Related Genes in the Blood of Children with Autism Spectrum Disorders. Sener EF, etal., J Mol Neurosci. 2019 Jan;67(1):89-96. doi: 10.1007/s12031-018-1213-0. Epub 2018 Dec 5.
51. Expression of the mu-opioid receptor is induced in dentate gyrus granule cells after focal cerebrocortical ischaemia and stimulation of entorhinal afferents. Stumm R, etal., Eur J Neurosci. 2005 Sep;22(5):1032-44.
52. The role of neuronal nitric oxide synthase in cocaine place preference and mu opioid receptor expression in the nucleus accumbens. Thériault RK, etal., Psychopharmacology (Berl). 2018 Sep;235(9):2675-2685. doi: 10.1007/s00213-018-4961-1. Epub 2018 Jul 10.
53. Haplotype-Based Association and In Silico Studies of OPRM1 Gene Variants with Susceptibility to Opioid Dependence Among Addicted Iranians Undergoing Methadone Treatment. Tolami HF, etal., J Mol Neurosci. 2020 Apr;70(4):504-513. doi: 10.1007/s12031-019-01443-4. Epub 2019 Dec 18.
54. Variations in opioid receptor genes in neonatal abstinence syndrome. Wachman EM, etal., Drug Alcohol Depend. 2015 Oct 1;155:253-9. doi: 10.1016/j.drugalcdep.2015.07.001. Epub 2015 Jul 8.
55. Association of OPRM1 and COMT single-nucleotide polymorphisms with hospital length of stay and treatment of neonatal abstinence syndrome. Wachman EM, etal., JAMA. 2013 May 1;309(17):1821-7. doi: 10.1001/jama.2013.3411.
56. Opioid Exposure is Associated with Aberrant DNA Methylation of OPRM1 Promoter Region in a Chinese Han Population. Xu J, etal., Biochem Genet. 2018 Oct;56(5):451-458. doi: 10.1007/s10528-018-9852-y. Epub 2018 Mar 21.
57. Methylation and expression quantitative trait loci rs1799971 in the OPRM1 gene and rs4654327 in the OPRD1 gene are associated with opioid use disorder. Yu J, etal., Neurosci Lett. 2023 Sep 25;814:137468. doi: 10.1016/j.neulet.2023.137468. Epub 2023 Sep 1.
58. Abnormal modulation of cholinergic neurotransmission by endomorphin 1 and endomorphin 2 in isolated bronchus of type 1 diabetic rats. Yu Y, etal., Peptides. 2006 Nov;27(11):2770-7. Epub 2006 Aug 9.
59. Effect of mu-opioid receptor gene polymorphisms on heroin-induced subjective responses in a Chinese population. Zhang D, etal., Biol Psychiatry. 2007 Jun 1;61(11):1244-51. doi: 10.1016/j.biopsych.2006.07.012. Epub 2006 Dec 8.
60. The mu-opioid receptor subtype is required for the anorectic effect of an opioid receptor antagonist. Zhang J, etal., Eur J Pharmacol. 2006 Sep 18;545(2-3):147-52. doi: 10.1016/j.ejphar.2006.06.069. Epub 2006 Jul 5.
61. Nerve Injury Diminishes Opioid Analgesia through Lysine Methyltransferase-mediated Transcriptional Repression of mu-Opioid Receptors in Primary Sensory Neurons. Zhang Y, etal., J Biol Chem. 2016 Apr 15;291(16):8475-85. doi: 10.1074/jbc.M115.711812. Epub 2016 Feb 25.
62. Association of OPRM1 Functional Coding Variant With Opioid Use Disorder: A Genome-Wide Association Study. Zhou H, etal., JAMA Psychiatry. 2020 Oct 1;77(10):1072-1080. doi: 10.1001/jamapsychiatry.2020.1206.
Additional References at PubMed
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PMID:10336124   PMID:10393893   PMID:10656608   PMID:10682855   PMID:10690754   PMID:10874510   PMID:11069979   PMID:11076532   PMID:11092766   PMID:11140838   PMID:11278523   PMID:11338173  
PMID:11445868   PMID:11457836   PMID:11751037   PMID:11840318   PMID:11933204   PMID:12031654   PMID:12068084   PMID:12123746   PMID:12141912   PMID:12142540   PMID:12210283   PMID:12357145  
PMID:12413885   PMID:12477932   PMID:12519790   PMID:12589820   PMID:12627468   PMID:12648891   PMID:12657887   PMID:12734358   PMID:12810704   PMID:12813472   PMID:12898579   PMID:14530949  
PMID:14532289   PMID:14573758   PMID:14623376   PMID:14744466   PMID:14745298   PMID:15007373   PMID:15037869   PMID:15086532   PMID:15167694   PMID:15194868   PMID:15252283   PMID:15322094  
PMID:15448191   PMID:15448587   PMID:15489334   PMID:15494033   PMID:15504181   PMID:15525999   PMID:15542732   PMID:15558714   PMID:15608594   PMID:15704610   PMID:15731588   PMID:15748148  
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PMID:16842630   PMID:16843022   PMID:16846840   PMID:16871067   PMID:16879459   PMID:16892066   PMID:16914208   PMID:16960700   PMID:17000822   PMID:17005904   PMID:17054695   PMID:17126529  
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PMID:19058789   PMID:19074885   PMID:19077058   PMID:19086053   PMID:19103668   PMID:19119631   PMID:19164126   PMID:19167252   PMID:19170196   PMID:19219857   PMID:19240053   PMID:19272466  
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Genomics

Comparative Map Data
OPRM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386154,010,496 - 154,246,867 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6154,010,496 - 154,246,867 (+)EnsemblGRCh38hg38GRCh38
GRCh376154,331,631 - 154,568,001 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366154,402,136 - 154,609,693 (+)NCBINCBI36Build 36hg18NCBI36
Build 346154,452,556 - 154,660,114NCBI
Celera6155,066,098 - 155,302,376 (+)NCBICelera
Cytogenetic Map6q25.2NCBI
HuRef6151,895,214 - 152,131,143 (+)NCBIHuRef
CHM1_16154,595,701 - 154,831,638 (+)NCBICHM1_1
T2T-CHM13v2.06155,212,511 - 155,448,859 (+)NCBIT2T-CHM13v2.0
Oprm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39106,708,593 - 6,988,209 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl106,708,506 - 6,988,198 (+)EnsemblGRCm39 Ensembl
GRCm38106,758,593 - 7,038,209 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl106,758,506 - 7,038,198 (+)EnsemblGRCm38mm10GRCm38
MGSCv37103,308,332 - 3,557,940 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36103,309,340 - 3,557,732 (-)NCBIMGSCv36mm8
Celera106,736,075 - 7,000,690 (+)NCBICelera
Cytogenetic Map10A1NCBI
cM Map101.85NCBI
Oprm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8145,565,371 - 45,818,722 (+)NCBIGRCr8
mRatBN7.2143,160,057 - 43,413,409 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl143,160,057 - 43,413,409 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx143,700,986 - 43,954,675 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0149,688,216 - 49,941,908 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0143,776,469 - 44,030,156 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0143,454,803 - 43,704,948 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl143,454,803 - 43,704,948 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0144,804,181 - 45,034,145 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4137,535,416 - 37,779,392 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1137,538,384 - 37,591,800 (+)NCBI
Celera138,804,246 - 39,057,359 (+)NCBICelera
RH 3.4 Map1468.6RGD
Cytogenetic Map1q11NCBI
Oprm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554397,757,569 - 7,923,817 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554397,870,563 - 7,923,817 (-)NCBIChiLan1.0ChiLan1.0
OPRM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25174,001,918 - 174,144,256 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16171,893,526 - 172,035,890 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06151,827,323 - 151,937,658 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16156,517,666 - 156,627,758 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6156,517,661 - 157,088,251 (+)Ensemblpanpan1.1panPan2
OPRM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1143,972,915 - 44,037,477 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl143,972,219 - 44,141,238 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha144,810,592 - 44,875,131 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0144,157,040 - 44,221,809 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl144,156,501 - 44,325,450 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1144,023,836 - 44,088,390 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0143,896,066 - 43,961,450 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0144,471,346 - 44,490,044 (+)NCBIUU_Cfam_GSD_1.0
Oprm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946139,253,997 - 139,325,813 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364896,506,207 - 6,548,946 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364896,506,207 - 6,567,136 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OPRM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl112,528,672 - 12,702,443 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1112,634,125 - 12,702,295 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2114,770,415 - 14,819,354 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1pNCBI
OPRM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11381,568,295 - 81,650,005 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1381,568,732 - 81,625,088 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604053,917,647 - 54,030,223 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Oprm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247854,032,689 - 4,196,186 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247854,147,079 - 4,195,712 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in OPRM1
455 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_000914.5(OPRM1):c.118A>G (p.Asn40Asp) single nucleotide variant Opioid dependence, susceptibility to, 1 [RCV000010146]|Tramadol response [RCV001029180] Chr6:154039662 [GRCh38]
Chr6:154039662..154039663 [GRCh38]
Chr6:154360797 [GRCh37]
Chr6:154360797..154360798 [GRCh37]
Chr6:6q25.2
drug response|uncertain significance
NM_001008503.2(OPRM1):c.1164+56726G>A single nucleotide variant Lung cancer [RCV000096627] Chr6:154148198 [GRCh38]
Chr6:154469333 [GRCh37]
Chr6:6q25.2
uncertain significance
GRCh38/hg38 6q24.1-27(chr6:141132990-169339571)x3 copy number gain See cases [RCV000050604] Chr6:141132990..169339571 [GRCh38]
Chr6:141454127..169739666 [GRCh37]
Chr6:141495820..169481591 [NCBI36]
Chr6:6q24.1-27
pathogenic
GRCh38/hg38 6q25.2-27(chr6:152376338-170583214)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051902]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051902]|See cases [RCV000051902] Chr6:152376338..170583214 [GRCh38]
Chr6:152697473..170892302 [GRCh37]
Chr6:152739166..170734227 [NCBI36]
Chr6:6q25.2-27
pathogenic
GRCh38/hg38 6q25.2-27(chr6:154118058-170602152)x1 copy number loss See cases [RCV000052207] Chr6:154118058..170602152 [GRCh38]
Chr6:154439193..170911240 [GRCh37]
Chr6:154480885..170753165 [NCBI36]
Chr6:6q25.2-27
pathogenic
NM_000914.4(OPRM1):c.499C>T (p.Arg167Ter) single nucleotide variant Malignant melanoma [RCV000067187] Chr6:154090034 [GRCh38]
Chr6:154411169 [GRCh37]
Chr6:154452862 [NCBI36]
Chr6:6q25.2
not provided
GRCh38/hg38 6q25.2-25.3(chr6:154178964-159020369)x1 copy number loss See cases [RCV000134896] Chr6:154178964..159020369 [GRCh38]
Chr6:154500098..159441401 [GRCh37]
Chr6:154541790..159361389 [NCBI36]
Chr6:6q25.2-25.3
likely pathogenic
GRCh38/hg38 6q23.3-25.3(chr6:135358150-155455117)x3 copy number gain See cases [RCV000136826] Chr6:135358150..155455117 [GRCh38]
Chr6:135679288..155776251 [GRCh37]
Chr6:135720981..155817943 [NCBI36]
Chr6:6q23.3-25.3
pathogenic
GRCh38/hg38 6q25.1-25.3(chr6:150381239-159553952)x1 copy number loss See cases [RCV000139578] Chr6:150381239..159553952 [GRCh38]
Chr6:150702375..159974984 [GRCh37]
Chr6:150744068..159894974 [NCBI36]
Chr6:6q25.1-25.3
pathogenic
GRCh38/hg38 6q25.2(chr6:153921611-154560027)x3 copy number gain See cases [RCV000139799] Chr6:153921611..154560027 [GRCh38]
Chr6:154242746..154881161 [GRCh37]
Chr6:154284439..154922853 [NCBI36]
Chr6:6q25.2
uncertain significance
GRCh38/hg38 6q25.2-27(chr6:152793402-170610394)x1 copy number loss See cases [RCV000141880] Chr6:152793402..170610394 [GRCh38]
Chr6:153114537..170919482 [GRCh37]
Chr6:153156230..170761407 [NCBI36]
Chr6:6q25.2-27
pathogenic
GRCh38/hg38 6q25.2-27(chr6:152376338-170612001)x3 copy number gain See cases [RCV000142594] Chr6:152376338..170612001 [GRCh38]
Chr6:152697473..170921089 [GRCh37]
Chr6:152739166..170763014 [NCBI36]
Chr6:6q25.2-27
pathogenic
GRCh38/hg38 6q23.2-27(chr6:133537271-165875545)x3 copy number gain See cases [RCV000143444] Chr6:133537271..165875545 [GRCh38]
Chr6:133858409..166289033 [GRCh37]
Chr6:133900102..166209023 [NCBI36]
Chr6:6q23.2-27
pathogenic
NM_001145279.3(OPRM1):c.-8245_-1+9405del deletion Gestational diabetes mellitus uncontrolled [RCV000161458] Chr6:154002774..154020423 [GRCh38]
Chr6:154323909..154341558 [GRCh37]
Chr6:6q25.2
not provided
GRCh37/hg19 6q25.1-27(chr6:151214792-170892243)x3 copy number gain See cases [RCV000449011] Chr6:151214792..170892243 [GRCh37]
Chr6:6q25.1-27
pathogenic
NM_000914.5(OPRM1):c.440C>G (p.Ser147Cys) single nucleotide variant Tramadol response [RCV001029134]|not specified [RCV000238970] Chr6:154089975 [GRCh38]
Chr6:154411110 [GRCh37]
Chr6:6q25.2
benign|drug response
GRCh37/hg19 6q25.2(chr6:154283654-154617461)x4 copy number gain See cases [RCV000449473] Chr6:154283654..154617461 [GRCh37]
Chr6:6q25.2
likely benign
GRCh37/hg19 6q25.2-25.3(chr6:153647248-158255989)x1 copy number loss See cases [RCV000446757] Chr6:153647248..158255989 [GRCh37]
Chr6:6q25.2-25.3
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
NM_000914.5(OPRM1):c.1165-11152C>T single nucleotide variant Tramadol response [RCV001029069]|not specified [RCV000455412] Chr6:154107531 [GRCh38]
Chr6:154428666 [GRCh37]
Chr6:6q25.2
benign|drug response
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
46,XX,der(6)(q25.1,q28)dn.seq[GRCh37/hg19]der(6)(6pter->6q25.2(+)(154768571)::q25.2(+)(154778901),q25.2(+)154778992::q25.2(-)(154774048),q25.2(-)(154768571)::q25.2(-)(154768571),q25.1(-)(~151443183-151443483))dn complex Coffin-Siris syndrome 1 [RCV000714957] Chr6:151443333..171115067 [GRCh37]
Chr6:6q25.1-27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6q25.1-27(chr6:150284435-170919470)x3 copy number gain not provided [RCV000746100] Chr6:150284435..170919470 [GRCh37]
Chr6:6q25.1-27
pathogenic
NM_001130700.2(IPCEF1):c.1104+1634G>A single nucleotide variant not provided [RCV001690438] Chr6:154166286 [GRCh38]
Chr6:154487421 [GRCh37]
Chr6:6q25.2
benign
NM_001130700.2(IPCEF1):c.553T>C (p.Ser185Pro) single nucleotide variant not provided [RCV000893994] Chr6:154200025 [GRCh38]
Chr6:154521159 [GRCh37]
Chr6:6q25.2
benign
NM_000914.5(OPRM1):c.21C>G (p.Pro7=) single nucleotide variant not provided [RCV000970150] Chr6:154039565 [GRCh38]
Chr6:154360700 [GRCh37]
Chr6:6q25.2
likely benign
NM_000914.5(OPRM1):c.942G>A (p.Thr314=) single nucleotide variant not provided [RCV000958889] Chr6:154091250 [GRCh38]
Chr6:154412385 [GRCh37]
Chr6:6q25.2
benign
NM_000914.5(OPRM1):c.141G>A (p.Pro47=) single nucleotide variant not provided [RCV000923431] Chr6:154039685 [GRCh38]
Chr6:154360820 [GRCh37]
Chr6:6q25.2
likely benign
NM_000914.5(OPRM1):c.778C>T (p.Arg260Cys) single nucleotide variant not specified [RCV004292455] Chr6:154091086 [GRCh38]
Chr6:154412221 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_001130700.2(IPCEF1):c.77-73C>A single nucleotide variant Tramadol response [RCV001028981] Chr6:154246833 [GRCh38]
Chr6:154567967 [GRCh37]
Chr6:6q25.2
drug response
NM_001130700.2(IPCEF1):c.77-63G>A single nucleotide variant Tramadol response [RCV001028983] Chr6:154246823 [GRCh38]
Chr6:154567957 [GRCh37]
Chr6:6q25.2
drug response
NM_001130700.2(IPCEF1):c.145C>T (p.Leu49=) single nucleotide variant Tramadol response [RCV001028986] Chr6:154246692 [GRCh38]
Chr6:154567826 [GRCh37]
Chr6:6q25.2
drug response
NM_001130700.2(IPCEF1):c.246+49C>T single nucleotide variant Tramadol response [RCV001028988] Chr6:154246542 [GRCh38]
Chr6:154567676 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*596C>A single nucleotide variant Tramadol response [RCV001028990] Chr6:154119317 [GRCh38]
Chr6:154440452 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*523T>C single nucleotide variant Tramadol response [RCV001028995] Chr6:154119244 [GRCh38]
Chr6:154440379 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*466C>T single nucleotide variant Tramadol response [RCV001029001] Chr6:154119187 [GRCh38]
Chr6:154440322 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*446T>G single nucleotide variant Tramadol response [RCV001029002] Chr6:154119167 [GRCh38]
Chr6:154440302 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*390_*391del deletion Tramadol response [RCV001029005] Chr6:154119110..154119111 [GRCh38]
Chr6:154440245..154440246 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*135C>T single nucleotide variant Tramadol response [RCV001029007] Chr6:154118856 [GRCh38]
Chr6:154439991 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*129T>A single nucleotide variant Tramadol response [RCV001029011] Chr6:154118850 [GRCh38]
Chr6:154439985 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*55G>A single nucleotide variant Tramadol response [RCV001029017] Chr6:154118776 [GRCh38]
Chr6:154439911 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1174C>T (p.Leu392=) single nucleotide variant Tramadol response [RCV001029021] Chr6:154118692 [GRCh38]
Chr6:154439827 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.644-125T>C single nucleotide variant Tramadol response [RCV001029121] Chr6:154090827 [GRCh38]
Chr6:154411962 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2031C>T single nucleotide variant Tramadol response [RCV001029147] Chr6:154087795 [GRCh38]
Chr6:154408930 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2846G>A single nucleotide variant Tramadol response [RCV001029160] Chr6:154086980 [GRCh38]
Chr6:154408115 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2900A>T single nucleotide variant Tramadol response [RCV001029163] Chr6:154086926 [GRCh38]
Chr6:154408061 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.290+121G>C single nucleotide variant Tramadol response [RCV001029171] Chr6:154039955 [GRCh38]
Chr6:154361090 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.290+107del deletion Tramadol response [RCV001029173] Chr6:154039938 [GRCh38]
Chr6:154361073 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.27C>T (p.Asn9=) single nucleotide variant Tramadol response [RCV001029184] Chr6:154039571 [GRCh38]
Chr6:154360706 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.-2C>A single nucleotide variant Tramadol response [RCV001029186] Chr6:154039543 [GRCh38]
Chr6:154360678 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.-71C>A single nucleotide variant Tramadol response [RCV001029192] Chr6:154039474 [GRCh38]
Chr6:154360609 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.-99T>A single nucleotide variant Tramadol response [RCV001029193] Chr6:154039446 [GRCh38]
Chr6:154360581 [GRCh37]
Chr6:6q25.2
drug response
NM_001145279.4(OPRM1):c.-1+51G>T single nucleotide variant Tramadol response [RCV001029205] Chr6:154011069 [GRCh38]
Chr6:154332204 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+151del deletion Tramadol response [RCV001029102] Chr6:154091621 [GRCh38]
Chr6:154412756 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*656G>T single nucleotide variant Tramadol response [RCV001028183] Chr6:154119377 [GRCh38]
Chr6:154440512 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*192T>G single nucleotide variant Tramadol response [RCV001028198] Chr6:154118913 [GRCh38]
Chr6:154440048 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*169C>T single nucleotide variant Tramadol response [RCV001028201] Chr6:154118890 [GRCh38]
Chr6:154440025 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-12C>T single nucleotide variant Tramadol response [RCV001028207] Chr6:154118671 [GRCh38]
Chr6:154439806 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10113T>G single nucleotide variant Tramadol response [RCV001028225] Chr6:154108570 [GRCh38]
Chr6:154429705 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10138A>C single nucleotide variant Tramadol response [RCV001028228] Chr6:154108545 [GRCh38]
Chr6:154429680 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10259G>A single nucleotide variant Tramadol response [RCV001028233] Chr6:154108424 [GRCh38]
Chr6:154429559 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10761C>A single nucleotide variant Tramadol response [RCV001028241] Chr6:154107922 [GRCh38]
Chr6:154429057 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+2046G>A single nucleotide variant Tramadol response [RCV001028264] Chr6:154093518 [GRCh38]
Chr6:154414653 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1768A>C single nucleotide variant Tramadol response [RCV001028268] Chr6:154093240 [GRCh38]
Chr6:154414375 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1753A>C single nucleotide variant Tramadol response [RCV001028269] Chr6:154093225 [GRCh38]
Chr6:154414360 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1748A>C single nucleotide variant Tramadol response [RCV001028271] Chr6:154093220 [GRCh38]
Chr6:154414355 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1727G>T single nucleotide variant Tramadol response [RCV001028275] Chr6:154093199 [GRCh38]
Chr6:154414334 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.757T>G (p.Cys253Gly) single nucleotide variant Tramadol response [RCV001028309] Chr6:154091065 [GRCh38]
Chr6:154412200 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.755T>G (p.Val252Gly) single nucleotide variant Tramadol response [RCV001028310] Chr6:154091063 [GRCh38]
Chr6:154412198 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.736C>T (p.Pro246Ser) single nucleotide variant Tramadol response [RCV001028314] Chr6:154091044 [GRCh38]
Chr6:154412179 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2288C>T single nucleotide variant Tramadol response [RCV001028340] Chr6:154087538 [GRCh38]
Chr6:154408673 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2441T>C single nucleotide variant Tramadol response [RCV001028346] Chr6:154087385 [GRCh38]
Chr6:154408520 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2917T>C single nucleotide variant Tramadol response [RCV001028350] Chr6:154086909 [GRCh38]
Chr6:154408044 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.224C>T (p.Ala75Val) single nucleotide variant Tramadol response [RCV001028370] Chr6:154039768 [GRCh38]
Chr6:154360903 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.-265T>A single nucleotide variant Tramadol response [RCV001028389] Chr6:154039280 [GRCh38]
Chr6:154360415 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.4(OPRM1):c.-357G>A single nucleotide variant Tramadol response [RCV001028391] Chr6:154039188 [GRCh38]
Chr6:154360323 [GRCh37]
Chr6:6q25.2
drug response
NM_001145279.4(OPRM1):c.-179A>T single nucleotide variant Tramadol response [RCV001028394] Chr6:154010840 [GRCh38]
Chr6:154331975 [GRCh37]
Chr6:6q25.2
drug response
NM_001145279.4(OPRM1):c.-384T>A single nucleotide variant Tramadol response [RCV001028404] Chr6:154010635 [GRCh38]
Chr6:154331770 [GRCh37]
Chr6:6q25.2
drug response
GRCh37/hg19 6q24.3-25.3(chr6:148195086-160127254)x3 copy number gain not provided [RCV000846496] Chr6:148195086..160127254 [GRCh37]
Chr6:6q24.3-25.3
pathogenic
NM_000914.5(OPRM1):c.291-2459A>C single nucleotide variant Tramadol response [RCV001029150] Chr6:154087367 [GRCh38]
Chr6:154408502 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2875G>T single nucleotide variant Tramadol response [RCV001029161] Chr6:154086951 [GRCh38]
Chr6:154408086 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-3445T>C single nucleotide variant Tramadol response [RCV001029169] Chr6:154086381 [GRCh38]
Chr6:154407516 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.290+87G>A single nucleotide variant Tramadol response [RCV001029174] Chr6:154039921 [GRCh38]
Chr6:154361056 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.290+72C>A single nucleotide variant Tramadol response [RCV001029175] Chr6:154039906 [GRCh38]
Chr6:154361041 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.290+18G>A single nucleotide variant Tramadol response [RCV001029177] Chr6:154039852 [GRCh38]
Chr6:154360987 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.-20C>T single nucleotide variant Tramadol response [RCV001029189] Chr6:154039525 [GRCh38]
Chr6:154360660 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.4(OPRM1):c.-394C>A single nucleotide variant Tramadol response [RCV001029194] Chr6:154039151 [GRCh38]
Chr6:154360286 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*788G>C single nucleotide variant Tramadol response [RCV001028176] Chr6:154119509 [GRCh38]
Chr6:154440644 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*720C>T single nucleotide variant Tramadol response [RCV001028178] Chr6:154119441 [GRCh38]
Chr6:154440576 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*674G>A single nucleotide variant Tramadol response [RCV001028179] Chr6:154119395 [GRCh38]
Chr6:154440530 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*375C>T single nucleotide variant Tramadol response [RCV001028188] Chr6:154119096 [GRCh38]
Chr6:154440231 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*175A>C single nucleotide variant Tramadol response [RCV001028200] Chr6:154118896 [GRCh38]
Chr6:154440031 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*148C>T single nucleotide variant Tramadol response [RCV001028202] Chr6:154118869 [GRCh38]
Chr6:154440004 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-7C>G single nucleotide variant Tramadol response [RCV001028206] Chr6:154118676 [GRCh38]
Chr6:154439811 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-8234G>A single nucleotide variant Tramadol response [RCV001028215] Chr6:154110449 [GRCh38]
Chr6:154431584 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-8253G>A single nucleotide variant Tramadol response [RCV001028216] Chr6:154110430 [GRCh38]
Chr6:154431565 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-8322G>T single nucleotide variant Tramadol response [RCV001028218] Chr6:154110361 [GRCh38]
Chr6:154431496 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-9998A>T single nucleotide variant Tramadol response [RCV001028222] Chr6:154108685 [GRCh38]
Chr6:154429820 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+275del deletion Tramadol response [RCV001028287] Chr6:154091744 [GRCh38]
Chr6:154412879 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+168T>G single nucleotide variant Tramadol response [RCV001028294] Chr6:154091640 [GRCh38]
Chr6:154412775 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1039C>T (p.Arg347Ter) single nucleotide variant Tramadol response [RCV001028299] Chr6:154091347 [GRCh38]
Chr6:154412482 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.596C>T (p.Ala199Val) single nucleotide variant Tramadol response [RCV001028321] Chr6:154090131 [GRCh38]
Chr6:154411266 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2259G>A single nucleotide variant Tramadol response [RCV001028337] Chr6:154087567 [GRCh38]
Chr6:154408702 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2910C>T single nucleotide variant Tramadol response [RCV001028348] Chr6:154086916 [GRCh38]
Chr6:154408051 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-3209T>A single nucleotide variant Tramadol response [RCV001028359] Chr6:154086617 [GRCh38]
Chr6:154407752 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.-225T>C single nucleotide variant Tramadol response [RCV001028386] Chr6:154039320 [GRCh38]
Chr6:154360455 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.-228C>T single nucleotide variant Tramadol response [RCV001028387] Chr6:154039317 [GRCh38]
Chr6:154360452 [GRCh37]
Chr6:6q25.2
drug response
NM_001145279.4(OPRM1):c.-191G>A single nucleotide variant Tramadol response [RCV001028396] Chr6:154010828 [GRCh38]
Chr6:154331963 [GRCh37]
Chr6:6q25.2
drug response
NM_001145279.4(OPRM1):c.-259A>G single nucleotide variant Tramadol response [RCV001028398] Chr6:154010760 [GRCh38]
Chr6:154331895 [GRCh37]
Chr6:6q25.2
drug response
GRCh37/hg19 6q25.2(chr6:154369847-154429434)x1 copy number loss not provided [RCV000849548] Chr6:154369847..154429434 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_001130700.2(IPCEF1):c.77-114C>A single nucleotide variant Tramadol response [RCV001028980] Chr6:154246874 [GRCh38]
Chr6:154568008 [GRCh37]
Chr6:6q25.2
drug response
NM_001130700.2(IPCEF1):c.246+45G>A single nucleotide variant Tramadol response [RCV001028987] Chr6:154246546 [GRCh38]
Chr6:154567680 [GRCh37]
Chr6:6q25.2
drug response
NM_001130700.2(IPCEF1):c.246+59A>C single nucleotide variant Tramadol response [RCV001028989] Chr6:154246532 [GRCh38]
Chr6:154567666 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*549del deletion Tramadol response [RCV001028993] Chr6:154119267 [GRCh38]
Chr6:154440402 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*513G>T single nucleotide variant Tramadol response [RCV001028997] Chr6:154119234 [GRCh38]
Chr6:154440369 [GRCh37]
Chr6:6q25.2
drug response
GRCh37/hg19 6q25.2(chr6:154240326-154902834)x3 copy number gain not provided [RCV001005860] Chr6:154240326..154902834 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_000914.5(OPRM1):c.*96C>T single nucleotide variant Tramadol response [RCV001029015] Chr6:154118817 [GRCh38]
Chr6:154439952 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*37G>C single nucleotide variant Tramadol response [RCV001029018] Chr6:154118758 [GRCh38]
Chr6:154439893 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10381C>T single nucleotide variant Tramadol response [RCV001029039] Chr6:154108302 [GRCh38]
Chr6:154429437 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10420C>G single nucleotide variant Tramadol response [RCV001029044] Chr6:154108263 [GRCh38]
Chr6:154429398 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10452C>A single nucleotide variant Tramadol response [RCV001029045] Chr6:154108231 [GRCh38]
Chr6:154429366 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10924del deletion Tramadol response [RCV001029061] Chr6:154107758 [GRCh38]
Chr6:154428893 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10943G>A single nucleotide variant Tramadol response [RCV001029062] Chr6:154107740 [GRCh38]
Chr6:154428875 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+427G>A single nucleotide variant Tramadol response [RCV001029098] Chr6:154091899 [GRCh38]
Chr6:154413034 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+307del deletion Tramadol response [RCV001029101] Chr6:154091779 [GRCh38]
Chr6:154412914 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1133C>T (p.Thr378Met) single nucleotide variant Tramadol response [RCV001029115] Chr6:154091441 [GRCh38]
Chr6:154412576 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.643+154A>C single nucleotide variant Tramadol response [RCV001029124] Chr6:154090332 [GRCh38]
Chr6:154411467 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.643+88C>A single nucleotide variant Tramadol response [RCV001029129] Chr6:154090266 [GRCh38]
Chr6:154411401 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-1972G>A single nucleotide variant Tramadol response [RCV001029143] Chr6:154087854 [GRCh38]
Chr6:154408989 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*796C>T single nucleotide variant Tramadol response [RCV001028174] Chr6:154119517 [GRCh38]
Chr6:154440652 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*669G>A single nucleotide variant Tramadol response [RCV001028180] Chr6:154119390 [GRCh38]
Chr6:154440525 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*642G>A single nucleotide variant Tramadol response [RCV001028185] Chr6:154119363 [GRCh38]
Chr6:154440498 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*309T>G single nucleotide variant Tramadol response [RCV001028192] Chr6:154119030 [GRCh38]
Chr6:154440165 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*138T>C single nucleotide variant Tramadol response [RCV001028203] Chr6:154118859 [GRCh38]
Chr6:154439994 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-9971C>G single nucleotide variant Tramadol response [RCV001028220] Chr6:154108712 [GRCh38]
Chr6:154429847 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-9979C>G single nucleotide variant Tramadol response [RCV001028221] Chr6:154108704 [GRCh38]
Chr6:154429839 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10336C>T single nucleotide variant Tramadol response [RCV001028234] Chr6:154108347 [GRCh38]
Chr6:154429482 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10757A>G single nucleotide variant Tramadol response [RCV001028238] Chr6:154107926 [GRCh38]
Chr6:154429061 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-11280C>T single nucleotide variant Tramadol response [RCV001028254] Chr6:154107403 [GRCh38]
Chr6:154428538 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+2071G>A single nucleotide variant Tramadol response [RCV001028261] Chr6:154093543 [GRCh38]
Chr6:154414678 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+2027G>A single nucleotide variant Tramadol response [RCV001028266] Chr6:154093499 [GRCh38]
Chr6:154414634 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1705T>C single nucleotide variant Tramadol response [RCV001028277] Chr6:154093177 [GRCh38]
Chr6:154414312 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1670del deletion Tramadol response [RCV001028280] Chr6:154093141 [GRCh38]
Chr6:154414276 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+270G>T single nucleotide variant Tramadol response [RCV001028288] Chr6:154091742 [GRCh38]
Chr6:154412877 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+224C>T single nucleotide variant Tramadol response [RCV001028291] Chr6:154091696 [GRCh38]
Chr6:154412831 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+212C>A single nucleotide variant Tramadol response [RCV001028292] Chr6:154091684 [GRCh38]
Chr6:154412819 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+162C>A single nucleotide variant Tramadol response [RCV001028297] Chr6:154091634 [GRCh38]
Chr6:154412769 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.958T>C (p.Trp320Arg) single nucleotide variant Tramadol response [RCV001028301] Chr6:154091266 [GRCh38]
Chr6:154412401 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.643+24G>T single nucleotide variant Tramadol response [RCV001028315] Chr6:154090202 [GRCh38]
Chr6:154411337 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.468C>T (p.Ser156=) single nucleotide variant Tramadol response [RCV001028330] Chr6:154090003 [GRCh38]
Chr6:154411138 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2204T>A single nucleotide variant Tramadol response [RCV001028332] Chr6:154087622 [GRCh38]
Chr6:154408757 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*653A>G single nucleotide variant Tramadol response [RCV001028184] Chr6:154119374 [GRCh38]
Chr6:154440509 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*291del deletion Tramadol response [RCV001028193] Chr6:154119009 [GRCh38]
Chr6:154440144 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*286A>G single nucleotide variant Tramadol response [RCV001028194] Chr6:154119007 [GRCh38]
Chr6:154440142 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-127G>A single nucleotide variant Tramadol response [RCV001028213] Chr6:154118556 [GRCh38]
Chr6:154439691 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-8309del deletion Tramadol response [RCV001028217] Chr6:154110371 [GRCh38]
Chr6:154431506 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10130C>T single nucleotide variant Tramadol response [RCV001028227] Chr6:154108553 [GRCh38]
Chr6:154429688 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10726del deletion Tramadol response [RCV001028237] Chr6:154107951 [GRCh38]
Chr6:154429086 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10785C>T single nucleotide variant Tramadol response [RCV001028243] Chr6:154107898 [GRCh38]
Chr6:154429033 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.290+4del deletion Tramadol response [RCV001028364] Chr6:154039837 [GRCh38]
Chr6:154360972 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.215C>T (p.Thr72Met) single nucleotide variant Tramadol response [RCV001028372] Chr6:154039759 [GRCh38]
Chr6:154360894 [GRCh37]
Chr6:6q25.2
drug response
NM_001145279.4(OPRM1):c.-190C>T single nucleotide variant Tramadol response [RCV001028395] Chr6:154010829 [GRCh38]
Chr6:154331964 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-11334T>C single nucleotide variant Tramadol response [RCV001028256] Chr6:154107349 [GRCh38]
Chr6:154428484 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-11342T>G single nucleotide variant Tramadol response [RCV001028259] Chr6:154107341 [GRCh38]
Chr6:154428476 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1816del deletion Tramadol response [RCV001028267] Chr6:154093286 [GRCh38]
Chr6:154414421 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1709C>T single nucleotide variant Tramadol response [RCV001028276] Chr6:154093181 [GRCh38]
Chr6:154414316 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+274A>C single nucleotide variant Tramadol response [RCV001028285] Chr6:154091746 [GRCh38]
Chr6:154412881 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.853C>T (p.Leu285=) single nucleotide variant Tramadol response [RCV001028303] Chr6:154091161 [GRCh38]
Chr6:154412296 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.582G>A (p.Trp194Ter) single nucleotide variant Tramadol response [RCV001028322] Chr6:154090117 [GRCh38]
Chr6:154411252 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.529G>A (p.Ala177Thr) single nucleotide variant Tramadol response [RCV001028326] Chr6:154090064 [GRCh38]
Chr6:154411199 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.523G>A (p.Val175Ile) single nucleotide variant Tramadol response [RCV001028328] Chr6:154090058 [GRCh38]
Chr6:154411193 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2279C>T single nucleotide variant Tramadol response [RCV001028339] Chr6:154087547 [GRCh38]
Chr6:154408682 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2309C>T single nucleotide variant Tramadol response [RCV001028342] Chr6:154087517 [GRCh38]
Chr6:154408652 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2368C>A single nucleotide variant Tramadol response [RCV001028344] Chr6:154087458 [GRCh38]
Chr6:154408593 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2959del deletion Tramadol response [RCV001028352] Chr6:154086864 [GRCh38]
Chr6:154407999 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-3230C>A single nucleotide variant Tramadol response [RCV001028360] Chr6:154086596 [GRCh38]
Chr6:154407731 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.223G>C (p.Ala75Pro) single nucleotide variant Tramadol response [RCV001028371] Chr6:154039767 [GRCh38]
Chr6:154360902 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.-111del deletion Tramadol response [RCV001028379] Chr6:154039434 [GRCh38]
Chr6:154360569 [GRCh37]
Chr6:6q25.2
drug response
NM_001145279.4(OPRM1):c.-354G>A single nucleotide variant Tramadol response [RCV001028402] Chr6:154010665 [GRCh38]
Chr6:154331800 [GRCh37]
Chr6:6q25.2
drug response
NM_001130700.2(IPCEF1):c.77-64G>A single nucleotide variant Tramadol response [RCV001028982] Chr6:154246824 [GRCh38]
Chr6:154567958 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*511C>T single nucleotide variant Tramadol response [RCV001028998] Chr6:154119232 [GRCh38]
Chr6:154440367 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*424T>G single nucleotide variant Tramadol response [RCV001029003] Chr6:154119145 [GRCh38]
Chr6:154440280 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*133T>C single nucleotide variant Tramadol response [RCV001029008] Chr6:154118854 [GRCh38]
Chr6:154439989 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-8366G>A single nucleotide variant Tramadol response [RCV001029023] Chr6:154110317 [GRCh38]
Chr6:154431452 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-9741A>G single nucleotide variant Tramadol response [RCV001029028] Chr6:154108942 [GRCh38]
Chr6:154430077 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-9968A>T single nucleotide variant Tramadol response [RCV001029037] Chr6:154108715 [GRCh38]
Chr6:154429850 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10394G>C single nucleotide variant Tramadol response [RCV001029040] Chr6:154108289 [GRCh38]
Chr6:154429424 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10525G>A single nucleotide variant Tramadol response [RCV001029046] Chr6:154108158 [GRCh38]
Chr6:154429293 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10606C>T single nucleotide variant Tramadol response [RCV001029049] Chr6:154108077 [GRCh38]
Chr6:154429212 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-11121A>C single nucleotide variant Tramadol response [RCV001029068] Chr6:154107562 [GRCh38]
Chr6:154428697 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1855T>C single nucleotide variant Tramadol response [RCV001029080] Chr6:154093327 [GRCh38]
Chr6:154414462 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1585G>A single nucleotide variant Tramadol response [RCV001029089] Chr6:154093057 [GRCh38]
Chr6:154414192 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+75G>A single nucleotide variant Tramadol response [RCV001029106] Chr6:154091547 [GRCh38]
Chr6:154412682 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+36G>A single nucleotide variant Tramadol response [RCV001029107] Chr6:154091508 [GRCh38]
Chr6:154412643 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1070_1071del (p.Ser357fs) microsatellite Tramadol response [RCV001029117] Chr6:154091376..154091377 [GRCh38]
Chr6:154412511..154412512 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.644-121T>C single nucleotide variant Tramadol response [RCV001029120] Chr6:154090831 [GRCh38]
Chr6:154411966 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.643+40G>C single nucleotide variant Tramadol response [RCV001029132] Chr6:154090218 [GRCh38]
Chr6:154411353 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.388T>A (p.Tyr130Asn) single nucleotide variant Tramadol response [RCV001029136] Chr6:154089923 [GRCh38]
Chr6:154411058 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-1977del deletion Tramadol response [RCV001029145] Chr6:154087847 [GRCh38]
Chr6:154408982 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2464G>A single nucleotide variant Tramadol response [RCV001029152] Chr6:154087362 [GRCh38]
Chr6:154408497 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*131T>C single nucleotide variant Tramadol response [RCV001029009] Chr6:154118852 [GRCh38]
Chr6:154439987 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*114T>A single nucleotide variant Tramadol response [RCV001029013] Chr6:154118835 [GRCh38]
Chr6:154439970 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*94C>T single nucleotide variant Tramadol response [RCV001029016] Chr6:154118815 [GRCh38]
Chr6:154439950 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-9838del deletion Tramadol response [RCV001029033] Chr6:154108840 [GRCh38]
Chr6:154429975 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10589C>T single nucleotide variant Tramadol response [RCV001029047] Chr6:154108094 [GRCh38]
Chr6:154429229 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10619C>T single nucleotide variant Tramadol response [RCV001029050] Chr6:154108064 [GRCh38]
Chr6:154429199 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-3440A>T single nucleotide variant Tramadol response [RCV001029168] Chr6:154086386 [GRCh38]
Chr6:154407521 [GRCh37]
Chr6:6q25.2
drug response
NM_001145279.4(OPRM1):c.1-123G>A single nucleotide variant Tramadol response [RCV001029199] Chr6:154039038 [GRCh38]
Chr6:154360173 [GRCh37]
Chr6:6q25.2
drug response
NM_001145279.4(OPRM1):c.1-128T>C single nucleotide variant Tramadol response [RCV001029201] Chr6:154039033 [GRCh38]
Chr6:154360168 [GRCh37]
Chr6:6q25.2
drug response
NM_001145279.4(OPRM1):c.-1+86_-1+87del deletion Tramadol response [RCV001029203] Chr6:154011104..154011105 [GRCh38]
Chr6:154332239..154332240 [GRCh37]
Chr6:6q25.2
drug response
NM_001145279.4(OPRM1):c.-11C>T single nucleotide variant Tramadol response [RCV001029208] Chr6:154011008 [GRCh38]
Chr6:154332143 [GRCh37]
Chr6:6q25.2
drug response
NM_001145279.4(OPRM1):c.-55A>T single nucleotide variant Tramadol response [RCV001029209] Chr6:154010964 [GRCh38]
Chr6:154332099 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+2011A>G single nucleotide variant Tramadol response [RCV001029070] Chr6:154093483 [GRCh38]
Chr6:154414618 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1584A>G single nucleotide variant Tramadol response [RCV001029090] Chr6:154093056 [GRCh38]
Chr6:154414191 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+522del deletion Tramadol response [RCV001029094] Chr6:154091993 [GRCh38]
Chr6:154413128 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+448del deletion Tramadol response [RCV001029097] Chr6:154091919 [GRCh38]
Chr6:154413054 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+409T>C single nucleotide variant Tramadol response [RCV001029099] Chr6:154091881 [GRCh38]
Chr6:154413016 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+9T>A single nucleotide variant Tramadol response [RCV001029109] Chr6:154091481 [GRCh38]
Chr6:154412616 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164G>A (p.Gln388=) single nucleotide variant Tramadol response [RCV001029110] Chr6:154091472 [GRCh38]
Chr6:154412607 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.644-83G>C single nucleotide variant Tramadol response [RCV001029119] Chr6:154090869 [GRCh38]
Chr6:154412004 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-28T>C single nucleotide variant Tramadol response [RCV001029138] Chr6:154089798 [GRCh38]
Chr6:154410933 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-1971G>T single nucleotide variant Tramadol response [RCV001029142] Chr6:154087855 [GRCh38]
Chr6:154408990 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-1976A>T single nucleotide variant Tramadol response [RCV001029144] Chr6:154087850 [GRCh38]
Chr6:154408985 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2462C>T single nucleotide variant Tramadol response [RCV001029151] Chr6:154087364 [GRCh38]
Chr6:154408499 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2801A>C single nucleotide variant Tramadol response [RCV001029158] Chr6:154087025 [GRCh38]
Chr6:154408160 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.74C>A (p.Ala25Glu) single nucleotide variant Tramadol response [RCV001029182] Chr6:154039618 [GRCh38]
Chr6:154360753 [GRCh37]
Chr6:6q25.2
drug response
NM_001130700.2(IPCEF1):c.77-38G>A single nucleotide variant Tramadol response [RCV001028984] Chr6:154246798 [GRCh38]
Chr6:154567932 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-9790del deletion Tramadol response [RCV001029030] Chr6:154108893 [GRCh38]
Chr6:154430028 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10370C>T single nucleotide variant Tramadol response [RCV001029038] Chr6:154108313 [GRCh38]
Chr6:154429448 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10596C>T single nucleotide variant Tramadol response [RCV001029048] Chr6:154108087 [GRCh38]
Chr6:154429222 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10906A>G single nucleotide variant Tramadol response [RCV001029057] Chr6:154107777 [GRCh38]
Chr6:154428912 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-11116A>G single nucleotide variant Tramadol response [RCV001029066] Chr6:154107567 [GRCh38]
Chr6:154428702 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-11117C>T single nucleotide variant Tramadol response [RCV001029067] Chr6:154107566 [GRCh38]
Chr6:154428701 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+2004G>A single nucleotide variant Tramadol response [RCV001029071] Chr6:154093476 [GRCh38]
Chr6:154414611 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1995C>T single nucleotide variant Tramadol response [RCV001029072] Chr6:154093467 [GRCh38]
Chr6:154414602 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1591C>A single nucleotide variant Tramadol response [RCV001029087] Chr6:154093063 [GRCh38]
Chr6:154414198 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1587C>A single nucleotide variant Tramadol response [RCV001029088] Chr6:154093059 [GRCh38]
Chr6:154414194 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+103del deletion Tramadol response [RCV001029103] Chr6:154091574 [GRCh38]
Chr6:154412709 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1159C>A (p.His387Asn) single nucleotide variant Tramadol response [RCV001029111] Chr6:154091467 [GRCh38]
Chr6:154412602 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.643+115del deletion Tramadol response [RCV001029126] Chr6:154090290 [GRCh38]
Chr6:154411425 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.643+52G>T single nucleotide variant Tramadol response [RCV001029130] Chr6:154090230 [GRCh38]
Chr6:154411365 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.643+31G>A single nucleotide variant Tramadol response [RCV001029133] Chr6:154090209 [GRCh38]
Chr6:154411344 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.392T>G (p.Leu131Arg) single nucleotide variant Tramadol response [RCV001029135] Chr6:154089927 [GRCh38]
Chr6:154411062 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-31T>G single nucleotide variant Tramadol response [RCV001029139] Chr6:154089795 [GRCh38]
Chr6:154410930 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2016T>C single nucleotide variant Tramadol response [RCV001029146] Chr6:154087810 [GRCh38]
Chr6:154408945 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2499C>T single nucleotide variant Tramadol response [RCV001029153] Chr6:154087327 [GRCh38]
Chr6:154408462 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2509del deletion Tramadol response [RCV001029154] Chr6:154087317 [GRCh38]
Chr6:154408452 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2529C>T single nucleotide variant Tramadol response [RCV001029155] Chr6:154087297 [GRCh38]
Chr6:154408432 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-3321A>C single nucleotide variant Tramadol response [RCV001029165] Chr6:154086505 [GRCh38]
Chr6:154407640 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-3322A>C single nucleotide variant Tramadol response [RCV001029166] Chr6:154086504 [GRCh38]
Chr6:154407639 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.290+22del deletion Tramadol response [RCV001029176] Chr6:154039855 [GRCh38]
Chr6:154360990 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.7A>G (p.Ser3Gly) single nucleotide variant Tramadol response [RCV001029185] Chr6:154039551 [GRCh38]
Chr6:154360686 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.-7C>T single nucleotide variant Tramadol response [RCV001029187] Chr6:154039538 [GRCh38]
Chr6:154360673 [GRCh37]
Chr6:6q25.2
drug response
NM_001145279.4(OPRM1):c.-2G>T single nucleotide variant Tramadol response [RCV001029207] Chr6:154011017 [GRCh38]
Chr6:154332152 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*662T>C single nucleotide variant Tramadol response [RCV001028181] Chr6:154119383 [GRCh38]
Chr6:154440518 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*600G>A single nucleotide variant Tramadol response [RCV001028187] Chr6:154119321 [GRCh38]
Chr6:154440456 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*338G>T single nucleotide variant Tramadol response [RCV001028190] Chr6:154119059 [GRCh38]
Chr6:154440194 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-121T>C single nucleotide variant Tramadol response [RCV001028211] Chr6:154118562 [GRCh38]
Chr6:154439697 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-125G>A single nucleotide variant Tramadol response [RCV001028212] Chr6:154118558 [GRCh38]
Chr6:154439693 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10072G>A single nucleotide variant Tramadol response [RCV001028224] Chr6:154108611 [GRCh38]
Chr6:154429746 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10357C>T single nucleotide variant Tramadol response [RCV001028235] Chr6:154108326 [GRCh38]
Chr6:154429461 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-11189A>C single nucleotide variant Tramadol response [RCV001028252] Chr6:154107494 [GRCh38]
Chr6:154428629 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1702T>A single nucleotide variant Tramadol response [RCV001028278] Chr6:154093174 [GRCh38]
Chr6:154414309 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+291C>T single nucleotide variant Tramadol response [RCV001028283] Chr6:154091763 [GRCh38]
Chr6:154412898 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+273A>T single nucleotide variant Tramadol response [RCV001028286] Chr6:154091745 [GRCh38]
Chr6:154412880 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1027G>T (p.Glu343Ter) single nucleotide variant Tramadol response [RCV001028300] Chr6:154091335 [GRCh38]
Chr6:154412470 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.800del (p.Leu267fs) deletion Tramadol response [RCV001028305] Chr6:154091108 [GRCh38]
Chr6:154412243 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.643+18C>T single nucleotide variant Tramadol response [RCV001028316] Chr6:154090196 [GRCh38]
Chr6:154411331 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2249G>A single nucleotide variant Tramadol response [RCV001028334] Chr6:154087577 [GRCh38]
Chr6:154408712 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10248G>A single nucleotide variant Tramadol response [RCV001028232] Chr6:154108435 [GRCh38]
Chr6:154429570 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.276_277del (p.Met92fs) deletion Tramadol response [RCV001028365] Chr6:154039819..154039820 [GRCh38]
Chr6:154360954..154360955 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.-105G>A single nucleotide variant Tramadol response [RCV001028377] Chr6:154039440 [GRCh38]
Chr6:154360575 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.-196G>T single nucleotide variant Tramadol response [RCV001028384] Chr6:154039349 [GRCh38]
Chr6:154360484 [GRCh37]
Chr6:6q25.2
drug response
NM_001145279.4(OPRM1):c.-194C>T single nucleotide variant Tramadol response [RCV001028397] Chr6:154010825 [GRCh38]
Chr6:154331960 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*764C>T single nucleotide variant Tramadol response [RCV001028177] Chr6:154119485 [GRCh38]
Chr6:154440620 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*659T>G single nucleotide variant Tramadol response [RCV001028182] Chr6:154119380 [GRCh38]
Chr6:154440515 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*356C>T single nucleotide variant Tramadol response [RCV001028189] Chr6:154119077 [GRCh38]
Chr6:154440212 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-111A>G single nucleotide variant Tramadol response [RCV001028209] Chr6:154118572 [GRCh38]
Chr6:154439707 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-128T>C single nucleotide variant Tramadol response [RCV001028214] Chr6:154118555 [GRCh38]
Chr6:154439690 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-8336C>T single nucleotide variant Tramadol response [RCV001028219] Chr6:154110347 [GRCh38]
Chr6:154431482 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10019del deletion Tramadol response [RCV001028223] Chr6:154108662 [GRCh38]
Chr6:154429797 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10170A>G single nucleotide variant Tramadol response [RCV001028229] Chr6:154108513 [GRCh38]
Chr6:154429648 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10695A>T single nucleotide variant Tramadol response [RCV001028236] Chr6:154107988 [GRCh38]
Chr6:154429123 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10759A>G single nucleotide variant Tramadol response [RCV001028240] Chr6:154107924 [GRCh38]
Chr6:154429059 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10820C>T single nucleotide variant Tramadol response [RCV001028246] Chr6:154107863 [GRCh38]
Chr6:154428998 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10823C>T single nucleotide variant Tramadol response [RCV001028247] Chr6:154107860 [GRCh38]
Chr6:154428995 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10853del deletion Tramadol response [RCV001028249] Chr6:154107827 [GRCh38]
Chr6:154428962 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-11182A>C single nucleotide variant Tramadol response [RCV001028251] Chr6:154107501 [GRCh38]
Chr6:154428636 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-11239C>T single nucleotide variant Tramadol response [RCV001028253] Chr6:154107444 [GRCh38]
Chr6:154428579 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-11281G>A single nucleotide variant Tramadol response [RCV001028255] Chr6:154107402 [GRCh38]
Chr6:154428537 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-11335T>C single nucleotide variant Tramadol response [RCV001028257] Chr6:154107348 [GRCh38]
Chr6:154428483 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-11339G>A single nucleotide variant Tramadol response [RCV001028258] Chr6:154107344 [GRCh38]
Chr6:154428479 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+2049T>C single nucleotide variant Tramadol response [RCV001028262] Chr6:154093521 [GRCh38]
Chr6:154414656 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+2043T>A single nucleotide variant Tramadol response [RCV001028265] Chr6:154093515 [GRCh38]
Chr6:154414650 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1751G>A single nucleotide variant Tramadol response [RCV001028270] Chr6:154093223 [GRCh38]
Chr6:154414358 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1738A>C single nucleotide variant Tramadol response [RCV001028274] Chr6:154093210 [GRCh38]
Chr6:154414345 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1660C>T single nucleotide variant Tramadol response [RCV001028281] Chr6:154093132 [GRCh38]
Chr6:154414267 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+266C>T single nucleotide variant Tramadol response [RCV001028289] Chr6:154091738 [GRCh38]
Chr6:154412873 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+204_1164+205del deletion Tramadol response [RCV001028293] Chr6:154091675..154091676 [GRCh38]
Chr6:154412810..154412811 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+161A>C single nucleotide variant Tramadol response [RCV001028298] Chr6:154091633 [GRCh38]
Chr6:154412768 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-3C>G single nucleotide variant Tramadol response [RCV001028205] Chr6:154118680 [GRCh38]
Chr6:154439815 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.866C>A (p.Ala289Asp) single nucleotide variant Tramadol response [RCV001028302] Chr6:154091174 [GRCh38]
Chr6:154412309 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.762T>G (p.Tyr254Ter) single nucleotide variant Tramadol response [RCV001028307] Chr6:154091070 [GRCh38]
Chr6:154412205 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.742C>T (p.Leu248Phe) single nucleotide variant Tramadol response [RCV001028312] Chr6:154091050 [GRCh38]
Chr6:154412185 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.640C>T (p.Gln214Ter) single nucleotide variant Tramadol response [RCV001028318] Chr6:154090175 [GRCh38]
Chr6:154411310 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.629C>T (p.Thr210Ile) single nucleotide variant Tramadol response [RCV001028319] Chr6:154090164 [GRCh38]
Chr6:154411299 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.604C>T (p.Leu202Phe) single nucleotide variant Tramadol response [RCV001028320] Chr6:154090139 [GRCh38]
Chr6:154411274 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.575G>T (p.Cys192Phe) single nucleotide variant Tramadol response [RCV001028323]|not provided [RCV003432991] Chr6:154090110 [GRCh38]
Chr6:154411245 [GRCh37]
Chr6:6q25.2
likely benign|drug response
NM_000914.5(OPRM1):c.550C>T (p.Arg184Ter) single nucleotide variant Tramadol response [RCV001028324] Chr6:154090085 [GRCh38]
Chr6:154411220 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.549C>T (p.Pro183=) single nucleotide variant Tramadol response [RCV001028325] Chr6:154090084 [GRCh38]
Chr6:154411219 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.528G>C (p.Lys176Asn) single nucleotide variant Tramadol response [RCV001028327] Chr6:154090063 [GRCh38]
Chr6:154411198 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.506T>G (p.Ile169Ser) single nucleotide variant Tramadol response [RCV001028329] Chr6:154090041 [GRCh38]
Chr6:154411176 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2144G>A single nucleotide variant Tramadol response [RCV001028331] Chr6:154087682 [GRCh38]
Chr6:154408817 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2208A>G single nucleotide variant Tramadol response [RCV001028333] Chr6:154087618 [GRCh38]
Chr6:154408753 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2251A>G single nucleotide variant Tramadol response [RCV001028336] Chr6:154087575 [GRCh38]
Chr6:154408710 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2260C>T single nucleotide variant Tramadol response [RCV001028338] Chr6:154087566 [GRCh38]
Chr6:154408701 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2324C>T single nucleotide variant Tramadol response [RCV001028343] Chr6:154087502 [GRCh38]
Chr6:154408637 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2389G>A single nucleotide variant Tramadol response [RCV001028345] Chr6:154087437 [GRCh38]
Chr6:154408572 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-3052G>A single nucleotide variant Tramadol response [RCV001028354] Chr6:154086774 [GRCh38]
Chr6:154407909 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-3090A>G single nucleotide variant Tramadol response [RCV001028355] Chr6:154086736 [GRCh38]
Chr6:154407871 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-3237C>A single nucleotide variant Tramadol response [RCV001028361] Chr6:154086589 [GRCh38]
Chr6:154407724 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.290+16G>A single nucleotide variant Tramadol response [RCV001028362] Chr6:154039850 [GRCh38]
Chr6:154360985 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.268C>T (p.Leu90=) single nucleotide variant Tramadol response [RCV001028366] Chr6:154039812 [GRCh38]
Chr6:154360947 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.230del (p.Tyr77fs) deletion Tramadol response [RCV001028369] Chr6:154039774 [GRCh38]
Chr6:154360909 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.194C>T (p.Pro65Leu) single nucleotide variant Tramadol response [RCV001028374] Chr6:154039738 [GRCh38]
Chr6:154360873 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.-102C>T single nucleotide variant Tramadol response [RCV001028376] Chr6:154039443 [GRCh38]
Chr6:154360578 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.-172G>T single nucleotide variant Tramadol response [RCV001028382] Chr6:154039373 [GRCh38]
Chr6:154360508 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.-281C>A single nucleotide variant Tramadol response [RCV001028390] Chr6:154039264 [GRCh38]
Chr6:154360399 [GRCh37]
Chr6:6q25.2
drug response
NM_001145279.4(OPRM1):c.-59TC[1] microsatellite Tramadol response [RCV001028392] Chr6:154010959..154010960 [GRCh38]
Chr6:154332094..154332095 [GRCh37]
Chr6:6q25.2
drug response
NM_001145279.4(OPRM1):c.-271del deletion Tramadol response [RCV001028399] Chr6:154010745 [GRCh38]
Chr6:154331880 [GRCh37]
Chr6:6q25.2
drug response
NM_001145279.4(OPRM1):c.-301T>A single nucleotide variant Tramadol response [RCV001028400] Chr6:154010718 [GRCh38]
Chr6:154331853 [GRCh37]
Chr6:6q25.2
drug response
NM_001145279.4(OPRM1):c.-358A>G single nucleotide variant Tramadol response [RCV001028403] Chr6:154010661 [GRCh38]
Chr6:154331796 [GRCh37]
Chr6:6q25.2
drug response
NC_000006.12:g.154010479C>T single nucleotide variant Tramadol response [RCV001028406] Chr6:154010479 [GRCh38]
Chr6:154331614 [GRCh37]
Chr6:6q25.2
drug response
NM_001130700.2(IPCEF1):c.77-143del deletion Tramadol response [RCV001028978] Chr6:154246903 [GRCh38]
Chr6:154568037 [GRCh37]
Chr6:6q25.2
drug response
NM_001130700.2(IPCEF1):c.77-131G>A single nucleotide variant Tramadol response [RCV001028979] Chr6:154246891 [GRCh38]
Chr6:154568025 [GRCh37]
Chr6:6q25.2
drug response
NM_001130700.2(IPCEF1):c.108G>A (p.Ser36=) single nucleotide variant Tramadol response [RCV001028985] Chr6:154246729 [GRCh38]
Chr6:154567863 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*571T>G single nucleotide variant Tramadol response [RCV001028991] Chr6:154119292 [GRCh38]
Chr6:154440427 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*515C>T single nucleotide variant Tramadol response [RCV001028996] Chr6:154119236 [GRCh38]
Chr6:154440371 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*487_*488del deletion Tramadol response [RCV001029000] Chr6:154119206..154119207 [GRCh38]
Chr6:154440341..154440342 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*124C>T single nucleotide variant Tramadol response [RCV001029012] Chr6:154118845 [GRCh38]
Chr6:154439980 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*108C>G single nucleotide variant Tramadol response [RCV001029014] Chr6:154118829 [GRCh38]
Chr6:154439964 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*19C>T single nucleotide variant Tramadol response [RCV001029019] Chr6:154118740 [GRCh38]
Chr6:154439875 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*9C>T single nucleotide variant Tramadol response [RCV001029020] Chr6:154118730 [GRCh38]
Chr6:154118730..154118731 [GRCh38]
Chr6:154439865 [GRCh37]
Chr6:154439865..154439866 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-8425C>G single nucleotide variant Tramadol response [RCV001029024] Chr6:154110258 [GRCh38]
Chr6:154431393 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-9696del deletion Tramadol response [RCV001029026] Chr6:154108987 [GRCh38]
Chr6:154430122 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-9965C>T single nucleotide variant Tramadol response [RCV001029036] Chr6:154108718 [GRCh38]
Chr6:154429853 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10409C>T single nucleotide variant Tramadol response [RCV001029041] Chr6:154108274 [GRCh38]
Chr6:154429409 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10410C>T single nucleotide variant Tramadol response [RCV001029042] Chr6:154108273 [GRCh38]
Chr6:154429408 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10411del deletion Tramadol response [RCV001029043] Chr6:154108271 [GRCh38]
Chr6:154429406 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10629T>C single nucleotide variant Tramadol response [RCV001029051] Chr6:154108054 [GRCh38]
Chr6:154429189 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10672C>T single nucleotide variant Tramadol response [RCV001029052] Chr6:154108011 [GRCh38]
Chr6:154429146 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10688T>C single nucleotide variant Tramadol response [RCV001029053] Chr6:154107995 [GRCh38]
Chr6:154429130 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10875C>T single nucleotide variant Tramadol response [RCV001029054] Chr6:154107808 [GRCh38]
Chr6:154428943 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10889G>A single nucleotide variant Tramadol response [RCV001029056] Chr6:154107794 [GRCh38]
Chr6:154428929 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-11101G>A single nucleotide variant Tramadol response [RCV001029065] Chr6:154107582 [GRCh38]
Chr6:154428717 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1978T>C single nucleotide variant Tramadol response [RCV001029073] Chr6:154093450 [GRCh38]
Chr6:154414585 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1973A>C single nucleotide variant Tramadol response [RCV001029074] Chr6:154093445 [GRCh38]
Chr6:154414580 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1966C>T single nucleotide variant Tramadol response [RCV001029075] Chr6:154093438 [GRCh38]
Chr6:154414573 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1924C>T single nucleotide variant Tramadol response [RCV001029077] Chr6:154093396 [GRCh38]
Chr6:154414531 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1906C>T single nucleotide variant Tramadol response [RCV001029078] Chr6:154093378 [GRCh38]
Chr6:154414513 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1852G>A single nucleotide variant Tramadol response [RCV001029081] Chr6:154093324 [GRCh38]
Chr6:154414459 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1844G>A single nucleotide variant Tramadol response [RCV001029082] Chr6:154093316 [GRCh38]
Chr6:154414451 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1842C>A single nucleotide variant Tramadol response [RCV001029083] Chr6:154093314 [GRCh38]
Chr6:154414449 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1834G>A single nucleotide variant Tramadol response [RCV001029085] Chr6:154093306 [GRCh38]
Chr6:154414441 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1598G>T single nucleotide variant Tramadol response [RCV001029086] Chr6:154093070 [GRCh38]
Chr6:154414205 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1583C>T single nucleotide variant Tramadol response [RCV001029091] Chr6:154093055 [GRCh38]
Chr6:154414190 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1582G>T single nucleotide variant Tramadol response [RCV001029092] Chr6:154093054 [GRCh38]
Chr6:154414189 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+556del deletion Tramadol response [RCV001029093] Chr6:154092028 [GRCh38]
Chr6:154413163 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+478A>G single nucleotide variant Tramadol response [RCV001029095] Chr6:154091950 [GRCh38]
Chr6:154413085 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+83C>A single nucleotide variant Tramadol response [RCV001029104] Chr6:154091555 [GRCh38]
Chr6:154412690 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+77T>C single nucleotide variant Tramadol response [RCV001029105] Chr6:154091549 [GRCh38]
Chr6:154412684 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+35G>A single nucleotide variant Tramadol response [RCV001029108] Chr6:154091507 [GRCh38]
Chr6:154412642 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1154C>A (p.Thr385Asn) single nucleotide variant Tramadol response [RCV001029112] Chr6:154091462 [GRCh38]
Chr6:154412597 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1149T>C (p.Asp383=) single nucleotide variant Tramadol response [RCV001029114] Chr6:154091457 [GRCh38]
Chr6:154412592 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1074C>T (p.Ser358=) single nucleotide variant Tramadol response [RCV001029116] Chr6:154091382 [GRCh38]
Chr6:154412517 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.644-25T>C single nucleotide variant Tramadol response [RCV001029118] Chr6:154090927 [GRCh38]
Chr6:154412062 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.643+109T>A single nucleotide variant Tramadol response [RCV001029127] Chr6:154090287 [GRCh38]
Chr6:154411422 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.643+106T>A single nucleotide variant Tramadol response [RCV001029128] Chr6:154090284 [GRCh38]
Chr6:154411419 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.643+47A>T single nucleotide variant Tramadol response [RCV001029131] Chr6:154090225 [GRCh38]
Chr6:154411360 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.345A>T (p.Ala115=) single nucleotide variant Tramadol response [RCV001029137] Chr6:154089880 [GRCh38]
Chr6:154411015 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-33A>T single nucleotide variant Tramadol response [RCV001029140] Chr6:154089793 [GRCh38]
Chr6:154410928 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-1967A>T single nucleotide variant Tramadol response [RCV001029141] Chr6:154087859 [GRCh38]
Chr6:154408994 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2049G>T single nucleotide variant Tramadol response [RCV001029148] Chr6:154087777 [GRCh38]
Chr6:154408912 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2722G>A single nucleotide variant Tramadol response [RCV001029157] Chr6:154087104 [GRCh38]
Chr6:154408239 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2811T>A single nucleotide variant Tramadol response [RCV001029159] Chr6:154087015 [GRCh38]
Chr6:154408150 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2876A>G single nucleotide variant Tramadol response [RCV001029162] Chr6:154086950 [GRCh38]
Chr6:154408085 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-3328T>G single nucleotide variant Tramadol response [RCV001029167] Chr6:154086498 [GRCh38]
Chr6:154407633 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.290+122G>A single nucleotide variant Tramadol response [RCV001029170] Chr6:154039956 [GRCh38]
Chr6:154361091 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.182C>T (p.Pro61Leu) single nucleotide variant Tramadol response [RCV001029178] Chr6:154039726 [GRCh38]
Chr6:154360861 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.78del (p.Ser27fs) deletion Tramadol response [RCV001029181] Chr6:154039620 [GRCh38]
Chr6:154360755 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.-14C>T single nucleotide variant Tramadol response [RCV001029188] Chr6:154039531 [GRCh38]
Chr6:154360666 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.-35C>T single nucleotide variant Tramadol response [RCV001029191] Chr6:154039510 [GRCh38]
Chr6:154360645 [GRCh37]
Chr6:6q25.2
drug response
NM_001145279.4(OPRM1):c.1-130C>A single nucleotide variant Tramadol response [RCV001029202] Chr6:154039031 [GRCh38]
Chr6:154360166 [GRCh37]
Chr6:6q25.2
drug response
NM_001145279.4(OPRM1):c.-1+70G>C single nucleotide variant Tramadol response [RCV001029204] Chr6:154011088 [GRCh38]
Chr6:154332223 [GRCh37]
Chr6:6q25.2
drug response
NM_001145279.4(OPRM1):c.-1+11G>T single nucleotide variant Tramadol response [RCV001029206] Chr6:154011029 [GRCh38]
Chr6:154332164 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*554T>A single nucleotide variant Tramadol response [RCV001028992] Chr6:154119275 [GRCh38]
Chr6:154440410 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*137C>G single nucleotide variant Tramadol response [RCV001029006] Chr6:154118858 [GRCh38]
Chr6:154439993 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-8354T>C single nucleotide variant Tramadol response [RCV001029022] Chr6:154110329 [GRCh38]
Chr6:154431464 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-9688T>C single nucleotide variant Tramadol response [RCV001029025] Chr6:154108995 [GRCh38]
Chr6:154430130 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-9792A>G single nucleotide variant Tramadol response [RCV001029031] Chr6:154108891 [GRCh38]
Chr6:154430026 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-9875G>A single nucleotide variant Tramadol response [RCV001029034] Chr6:154108808 [GRCh38]
Chr6:154429943 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10879C>T single nucleotide variant Tramadol response [RCV001029055] Chr6:154107804 [GRCh38]
Chr6:154428939 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10912T>C single nucleotide variant Tramadol response [RCV001029058] Chr6:154107771 [GRCh38]
Chr6:154428906 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10915T>G single nucleotide variant Tramadol response [RCV001029060] Chr6:154107768 [GRCh38]
Chr6:154428903 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1956A>G single nucleotide variant Tramadol response [RCV001029076] Chr6:154093428 [GRCh38]
Chr6:154414563 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1902T>C single nucleotide variant Tramadol response [RCV001029079] Chr6:154093374 [GRCh38]
Chr6:154414509 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+314A>T single nucleotide variant Tramadol response [RCV001029100] Chr6:154091786 [GRCh38]
Chr6:154412921 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1150A>G (p.Arg384Gly) single nucleotide variant Tramadol response [RCV001029113] Chr6:154091458 [GRCh38]
Chr6:154412593 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.644-129A>C single nucleotide variant Tramadol response [RCV001029122] Chr6:154090823 [GRCh38]
Chr6:154411958 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.643+173T>A single nucleotide variant Tramadol response [RCV001029123] Chr6:154090351 [GRCh38]
Chr6:154411486 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2139G>A single nucleotide variant Tramadol response [RCV001029149] Chr6:154087687 [GRCh38]
Chr6:154408822 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2628A>G single nucleotide variant Tramadol response [RCV001029156] Chr6:154087198 [GRCh38]
Chr6:154408333 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.152del (p.Asp51fs) deletion Tramadol response [RCV001029179] Chr6:154039696 [GRCh38]
Chr6:154360831 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.53C>T (p.Ala18Val) single nucleotide variant Tramadol response [RCV001029183] Chr6:154039597 [GRCh38]
Chr6:154360732 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.-25C>T single nucleotide variant Tramadol response [RCV001029190]|not provided [RCV003432992] Chr6:154039520 [GRCh38]
Chr6:154360655 [GRCh37]
Chr6:6q25.2
likely benign|drug response
NM_001145279.4(OPRM1):c.1-126C>A single nucleotide variant Tramadol response [RCV001029200] Chr6:154039035 [GRCh38]
Chr6:154360170 [GRCh37]
Chr6:6q25.2
drug response
NM_001130700.2(IPCEF1):c.246+80A>G single nucleotide variant Tramadol response [RCV001028173] Chr6:154246511 [GRCh38]
Chr6:154567645 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*789T>C single nucleotide variant Tramadol response [RCV001028175] Chr6:154119510 [GRCh38]
Chr6:154440645 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*637C>G single nucleotide variant Tramadol response [RCV001028186] Chr6:154119358 [GRCh38]
Chr6:154440493 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*262C>T single nucleotide variant Tramadol response [RCV001028195] Chr6:154118983 [GRCh38]
Chr6:154440118 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*222G>A single nucleotide variant Tramadol response [RCV001028196] Chr6:154118943 [GRCh38]
Chr6:154440078 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*217G>A single nucleotide variant Tramadol response [RCV001028197] Chr6:154118938 [GRCh38]
Chr6:154440073 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*183T>C single nucleotide variant Tramadol response [RCV001028199] Chr6:154118904 [GRCh38]
Chr6:154440039 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10182del deletion Tramadol response [RCV001028230] Chr6:154108498 [GRCh38]
Chr6:154429633 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10201C>G single nucleotide variant Tramadol response [RCV001028231] Chr6:154108482 [GRCh38]
Chr6:154429617 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10777T>C single nucleotide variant Tramadol response [RCV001028242] Chr6:154107906 [GRCh38]
Chr6:154429041 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10799A>C single nucleotide variant Tramadol response [RCV001028244] Chr6:154107884 [GRCh38]
Chr6:154429019 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10800C>T single nucleotide variant Tramadol response [RCV001028245] Chr6:154107883 [GRCh38]
Chr6:154429018 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10840C>T single nucleotide variant Tramadol response [RCV001028248] Chr6:154107843 [GRCh38]
Chr6:154428978 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+2097G>A single nucleotide variant Tramadol response [RCV001028260] Chr6:154093569 [GRCh38]
Chr6:154414704 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1742A>G single nucleotide variant Tramadol response [RCV001028272] Chr6:154093214 [GRCh38]
Chr6:154414349 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1739A>C single nucleotide variant Tramadol response [RCV001028273] Chr6:154093211 [GRCh38]
Chr6:154414346 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1701G>A single nucleotide variant Tramadol response [RCV001028279] Chr6:154093173 [GRCh38]
Chr6:154414308 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1650T>C single nucleotide variant Tramadol response [RCV001028282] Chr6:154093122 [GRCh38]
Chr6:154414257 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+286del deletion Tramadol response [RCV001028284] Chr6:154091756 [GRCh38]
Chr6:154412891 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+258C>T single nucleotide variant Tramadol response [RCV001028290] Chr6:154091730 [GRCh38]
Chr6:154412865 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.739G>A (p.Val247Met) single nucleotide variant Tramadol response [RCV001028313] Chr6:154091047 [GRCh38]
Chr6:154412182 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2250G>A single nucleotide variant Tramadol response [RCV001028335] Chr6:154087576 [GRCh38]
Chr6:154408711 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2293del deletion Tramadol response [RCV001028341] Chr6:154087530 [GRCh38]
Chr6:154408665 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2905A>C single nucleotide variant Tramadol response [RCV001028347] Chr6:154086921 [GRCh38]
Chr6:154408056 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2911G>A single nucleotide variant Tramadol response [RCV001028349] Chr6:154086915 [GRCh38]
Chr6:154408050 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-3182A>G single nucleotide variant Tramadol response [RCV001028357] Chr6:154086644 [GRCh38]
Chr6:154407779 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-3191A>G single nucleotide variant Tramadol response [RCV001028358] Chr6:154086635 [GRCh38]
Chr6:154407770 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.290+6del deletion Tramadol response [RCV001028363] Chr6:154039839 [GRCh38]
Chr6:154360974 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.193C>T (p.Pro65Ser) single nucleotide variant Tramadol response [RCV001028375] Chr6:154039737 [GRCh38]
Chr6:154360872 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.-148C>T single nucleotide variant Tramadol response [RCV001028380] Chr6:154039397 [GRCh38]
Chr6:154360532 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.-191G>A single nucleotide variant Tramadol response [RCV001028383] Chr6:154039354 [GRCh38]
Chr6:154360489 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.-237G>T single nucleotide variant Tramadol response [RCV001028388] Chr6:154039308 [GRCh38]
Chr6:154360443 [GRCh37]
Chr6:6q25.2
drug response
NM_001145279.4(OPRM1):c.-98del deletion Tramadol response [RCV001028393] Chr6:154010918 [GRCh38]
Chr6:154332053 [GRCh37]
Chr6:6q25.2
drug response
NM_001145279.4(OPRM1):c.-304G>A single nucleotide variant Tramadol response [RCV001028401] Chr6:154010715 [GRCh38]
Chr6:154331850 [GRCh37]
Chr6:6q25.2
drug response
NM_001145279.4(OPRM1):c.-427A>C single nucleotide variant Tramadol response [RCV001028405] Chr6:154010592 [GRCh38]
Chr6:154331727 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*322_*323del deletion Tramadol response [RCV001028191] Chr6:154119043..154119044 [GRCh38]
Chr6:154440178..154440179 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-2A>C single nucleotide variant Tramadol response [RCV001028204] Chr6:154118681 [GRCh38]
Chr6:154439816 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-27C>T single nucleotide variant Tramadol response [RCV001028208] Chr6:154118656 [GRCh38]
Chr6:154439791 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-119C>T single nucleotide variant Tramadol response [RCV001028210] Chr6:154118564 [GRCh38]
Chr6:154439699 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10127A>C single nucleotide variant Tramadol response [RCV001028226] Chr6:154108556 [GRCh38]
Chr6:154429691 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10758A>T single nucleotide variant Tramadol response [RCV001028239] Chr6:154107925 [GRCh38]
Chr6:154429060 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10860C>G single nucleotide variant Tramadol response [RCV001028250] Chr6:154107823 [GRCh38]
Chr6:154428958 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+2048C>A single nucleotide variant Tramadol response [RCV001028263] Chr6:154093520 [GRCh38]
Chr6:154414655 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+164G>A single nucleotide variant Tramadol response [RCV001028295] Chr6:154091636 [GRCh38]
Chr6:154412771 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+163T>A single nucleotide variant Tramadol response [RCV001028296] Chr6:154091635 [GRCh38]
Chr6:154412770 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.809C>T (p.Ser270Phe) single nucleotide variant Tramadol response [RCV001028304] Chr6:154091117 [GRCh38]
Chr6:154412252 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.767T>G (p.Leu256Arg) single nucleotide variant Tramadol response [RCV001028306] Chr6:154091075 [GRCh38]
Chr6:154412210 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.760T>A (p.Tyr254Asn) single nucleotide variant Tramadol response [RCV001028308] Chr6:154091068 [GRCh38]
Chr6:154412203 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.754G>A (p.Val252Met) single nucleotide variant Tramadol response [RCV001028311] Chr6:154091062 [GRCh38]
Chr6:154412197 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.643+15C>T single nucleotide variant Tramadol response [RCV001028317] Chr6:154090193 [GRCh38]
Chr6:154411328 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2942del deletion Tramadol response [RCV001028351] Chr6:154086883 [GRCh38]
Chr6:154408018 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-2994C>T single nucleotide variant Tramadol response [RCV001028353] Chr6:154086832 [GRCh38]
Chr6:154407967 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-3097A>G single nucleotide variant Tramadol response [RCV001028356] Chr6:154086729 [GRCh38]
Chr6:154407864 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.243C>T (p.Cys81=) single nucleotide variant Tramadol response [RCV001028367] Chr6:154039787 [GRCh38]
Chr6:154360922 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.234del (p.Ile79fs) deletion Tramadol response [RCV001028368] Chr6:154039777 [GRCh38]
Chr6:154360912 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.204C>T (p.Ile68=) single nucleotide variant Tramadol response [RCV001028373] Chr6:154039748 [GRCh38]
Chr6:154360883 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.-109G>A single nucleotide variant Tramadol response [RCV001028378] Chr6:154039436 [GRCh38]
Chr6:154360571 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.-167G>A single nucleotide variant Tramadol response [RCV001028381] Chr6:154039378 [GRCh38]
Chr6:154360513 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.-209G>T single nucleotide variant Tramadol response [RCV001028385] Chr6:154039336 [GRCh38]
Chr6:154360471 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*544G>A single nucleotide variant Tramadol response [RCV001028994] Chr6:154119265 [GRCh38]
Chr6:154440400 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*494del deletion Tramadol response [RCV001028999] Chr6:154119215 [GRCh38]
Chr6:154440350 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*416A>C single nucleotide variant Tramadol response [RCV001029004] Chr6:154119137 [GRCh38]
Chr6:154440272 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.*132_*133del deletion Tramadol response [RCV001029010] Chr6:154118852..154118853 [GRCh38]
Chr6:154439987..154439988 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-9737G>A single nucleotide variant Tramadol response [RCV001029027] Chr6:154108946 [GRCh38]
Chr6:154430081 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-9783A>T single nucleotide variant Tramadol response [RCV001029029] Chr6:154108900 [GRCh38]
Chr6:154430035 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-9833G>A single nucleotide variant Tramadol response [RCV001029032] Chr6:154108850 [GRCh38]
Chr6:154429985 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-9956del deletion Tramadol response [RCV001029035] Chr6:154108727 [GRCh38]
Chr6:154429862 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10913C>T single nucleotide variant Tramadol response [RCV001029059] Chr6:154107770 [GRCh38]
Chr6:154428905 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10972G>A single nucleotide variant Tramadol response [RCV001029063] Chr6:154107711 [GRCh38]
Chr6:154428846 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1165-10999G>A single nucleotide variant Tramadol response [RCV001029064] Chr6:154107684 [GRCh38]
Chr6:154428819 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+1839A>T single nucleotide variant Tramadol response [RCV001029084] Chr6:154093311 [GRCh38]
Chr6:154414446 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.1164+469C>G single nucleotide variant Tramadol response [RCV001029096] Chr6:154091941 [GRCh38]
Chr6:154413076 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.643+138del deletion Tramadol response [RCV001029125] Chr6:154090310 [GRCh38]
Chr6:154411445 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.291-3240A>T single nucleotide variant Tramadol response [RCV001029164] Chr6:154086586 [GRCh38]
Chr6:154407721 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.5(OPRM1):c.290+118G>A single nucleotide variant Tramadol response [RCV001029172] Chr6:154039952 [GRCh38]
Chr6:154361087 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.4(OPRM1):c.-395C>T single nucleotide variant Tramadol response [RCV001029195] Chr6:154039150 [GRCh38]
Chr6:154360285 [GRCh37]
Chr6:6q25.2
drug response
NM_000914.4(OPRM1):c.-401C>A single nucleotide variant Tramadol response [RCV001029196] Chr6:154039144 [GRCh38]
Chr6:154360279 [GRCh37]
Chr6:6q25.2
drug response
NM_001145279.4(OPRM1):c.1-121T>C single nucleotide variant Tramadol response [RCV001029197] Chr6:154039040 [GRCh38]
Chr6:154360175 [GRCh37]
Chr6:6q25.2
drug response
NM_001145279.4(OPRM1):c.1-122A>G single nucleotide variant Tramadol response [RCV001029198] Chr6:154039039 [GRCh38]
Chr6:154360174 [GRCh37]
Chr6:6q25.2
drug response
GRCh37/hg19 6q25.1-25.2(chr6:151472860-154839846)x3 copy number gain not provided [RCV001258753] Chr6:151472860..154839846 [GRCh37]
Chr6:6q25.1-25.2
likely pathogenic
GRCh37/hg19 6q25.2-26(chr6:153207930-164322346) copy number loss not specified [RCV002053640] Chr6:153207930..164322346 [GRCh37]
Chr6:6q25.2-26
pathogenic
GRCh37/hg19 6q25.2-25.3(chr6:153584880-157203309)x1 copy number loss not provided [RCV001834309] Chr6:153584880..157203309 [GRCh37]
Chr6:6q25.2-25.3
pathogenic
GRCh37/hg19 6q25.2-25.3(chr6:153647248-158255989) copy number loss not specified [RCV002053641] Chr6:153647248..158255989 [GRCh37]
Chr6:6q25.2-25.3
pathogenic
GRCh37/hg19 6q25.2-25.3(chr6:153180239-156377315) copy number loss not specified [RCV002053639] Chr6:153180239..156377315 [GRCh37]
Chr6:6q25.2-25.3
uncertain significance
NM_001130700.2(IPCEF1):c.436A>T (p.Thr146Ser) single nucleotide variant not specified [RCV004237489] Chr6:154214233 [GRCh38]
Chr6:154535367 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_000914.5(OPRM1):c.764G>A (p.Gly255Glu) single nucleotide variant not specified [RCV004081219] Chr6:154091072 [GRCh38]
Chr6:154412207 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_001130700.2(IPCEF1):c.923T>G (p.Val308Gly) single nucleotide variant not specified [RCV004150850] Chr6:154168101 [GRCh38]
Chr6:154489236 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_000914.5(OPRM1):c.1029A>C (p.Glu343Asp) single nucleotide variant not specified [RCV004192945] Chr6:154091337 [GRCh38]
Chr6:154412472 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_000914.5(OPRM1):c.13G>A (p.Ala5Thr) single nucleotide variant not specified [RCV004237635] Chr6:154039557 [GRCh38]
Chr6:154360692 [GRCh37]
Chr6:6q25.2
likely benign
NM_001130700.2(IPCEF1):c.421A>C (p.Ile141Leu) single nucleotide variant not specified [RCV004231250] Chr6:154214248 [GRCh38]
Chr6:154535382 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_000914.5(OPRM1):c.823A>G (p.Arg275Gly) single nucleotide variant not specified [RCV004102969] Chr6:154091131 [GRCh38]
Chr6:154412266 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_000914.5(OPRM1):c.515G>A (p.Cys172Tyr) single nucleotide variant not specified [RCV004104048] Chr6:154090050 [GRCh38]
Chr6:154411185 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_001130700.2(IPCEF1):c.1312A>G (p.Ile438Val) single nucleotide variant not specified [RCV004206371] Chr6:154159833 [GRCh38]
Chr6:154480968 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_000914.5(OPRM1):c.27C>A (p.Asn9Lys) single nucleotide variant not specified [RCV004217195] Chr6:154039571 [GRCh38]
Chr6:154360706 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_000914.5(OPRM1):c.519C>A (p.His173Gln) single nucleotide variant not specified [RCV004167370] Chr6:154090054 [GRCh38]
Chr6:154411189 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_000914.5(OPRM1):c.401C>G (p.Thr134Arg) single nucleotide variant not specified [RCV004089584] Chr6:154089936 [GRCh38]
Chr6:154411071 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_000914.5(OPRM1):c.1126C>T (p.Pro376Ser) single nucleotide variant not specified [RCV004095701] Chr6:154091434 [GRCh38]
Chr6:154412569 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_000914.5(OPRM1):c.1115C>T (p.Thr372Ile) single nucleotide variant not specified [RCV004252976] Chr6:154091423 [GRCh38]
Chr6:154412558 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_000914.5(OPRM1):c.824G>A (p.Arg275Lys) single nucleotide variant not specified [RCV004255940] Chr6:154091132 [GRCh38]
Chr6:154412267 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_000914.5(OPRM1):c.993C>G (p.Ser331Arg) single nucleotide variant not specified [RCV004251350] Chr6:154091301 [GRCh38]
Chr6:154412436 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_000914.5(OPRM1):c.997C>T (p.Leu333Phe) single nucleotide variant not specified [RCV004269702] Chr6:154091305 [GRCh38]
Chr6:154412440 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_000914.5(OPRM1):c.557C>A (p.Ala186Asp) single nucleotide variant not specified [RCV004276046] Chr6:154090092 [GRCh38]
Chr6:154411227 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_000914.5(OPRM1):c.375C>G (p.Phe125Leu) single nucleotide variant not specified [RCV004261413] Chr6:154089910 [GRCh38]
Chr6:154411045 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_001130700.2(IPCEF1):c.413C>T (p.Ser138Leu) single nucleotide variant not specified [RCV004253555] Chr6:154214256 [GRCh38]
Chr6:154535390 [GRCh37]
Chr6:6q25.2
likely benign
GRCh38/hg38 6q25.1-25.3(chr6:150905553-158511926)x1 copy number loss Coffin-Siris syndrome 1 [RCV003327723] Chr6:150905553..158511926 [GRCh38]
Chr6:6q25.1-25.3
pathogenic
NM_000914.5(OPRM1):c.1142C>T (p.Thr381Ile) single nucleotide variant not specified [RCV004366002] Chr6:154091450 [GRCh38]
Chr6:154412585 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_000914.5(OPRM1):c.187_189dup (p.Gly63_Ser64insGly) duplication not provided [RCV003429003] Chr6:154039729..154039730 [GRCh38]
Chr6:154360864..154360865 [GRCh37]
Chr6:6q25.2
likely benign
GRCh37/hg19 6q22.31-25.3(chr6:119840686-156623091)x3 copy number gain not specified [RCV003986631] Chr6:119840686..156623091 [GRCh37]
Chr6:6q22.31-25.3
pathogenic
GRCh37/hg19 6q25.2-27(chr6:152853218-170914297)x1 copy number loss See cases [RCV004442824] Chr6:152853218..170914297 [GRCh37]
Chr6:6q25.2-27
pathogenic
NC_000006.12:g.(?_150381239)_(159553952_?)del deletion Chromosome 6q24-q25 deletion syndrome [RCV003884000] Chr6:150381239..159553952 [GRCh38]
Chr6:6q25.1-25.3
pathogenic
NM_000914.5(OPRM1):c.160G>A (p.Gly54Arg) single nucleotide variant not specified [RCV004499313] Chr6:154039704 [GRCh38]
Chr6:154360839 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_000914.5(OPRM1):c.979G>T (p.Gly327Cys) single nucleotide variant not specified [RCV004499317] Chr6:154091287 [GRCh38]
Chr6:154412422 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_000914.5(OPRM1):c.1048A>G (p.Arg350Gly) single nucleotide variant not specified [RCV004499311] Chr6:154091356 [GRCh38]
Chr6:154412491 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_000914.5(OPRM1):c.551G>A (p.Arg184Gln) single nucleotide variant not specified [RCV004499316] Chr6:154090086 [GRCh38]
Chr6:154411221 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_000914.5(OPRM1):c.311C>A (p.Ala104Asp) single nucleotide variant not specified [RCV004499314] Chr6:154089846 [GRCh38]
Chr6:154410981 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_000914.5(OPRM1):c.1063C>A (p.Pro355Thr) single nucleotide variant not specified [RCV004499312] Chr6:154091371 [GRCh38]
Chr6:154412506 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_000914.5(OPRM1):c.520C>G (p.Pro174Ala) single nucleotide variant not specified [RCV004499315] Chr6:154090055 [GRCh38]
Chr6:154411190 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_001130700.2(IPCEF1):c.509C>T (p.Pro170Leu) single nucleotide variant not specified [RCV004630912] Chr6:154212798 [GRCh38]
Chr6:154533932 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_001130700.2(IPCEF1):c.517G>A (p.Ala173Thr) single nucleotide variant not specified [RCV004626431] Chr6:154212790 [GRCh38]
Chr6:154533924 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_000914.5(OPRM1):c.40A>G (p.Thr14Ala) single nucleotide variant not specified [RCV004646169] Chr6:154039584 [GRCh38]
Chr6:154360719 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_000914.5(OPRM1):c.494T>A (p.Val165Asp) single nucleotide variant not specified [RCV004655214] Chr6:154090029 [GRCh38]
Chr6:154411164 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_001130700.2(IPCEF1):c.610A>G (p.Thr204Ala) single nucleotide variant not specified [RCV004630916] Chr6:154199968 [GRCh38]
Chr6:154521102 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_001130700.2(IPCEF1):c.783C>A (p.Asn261Lys) single nucleotide variant not specified [RCV004626432] Chr6:154199795 [GRCh38]
Chr6:154520929 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_001130700.2(IPCEF1):c.719C>T (p.Thr240Met) single nucleotide variant not specified [RCV004630913] Chr6:154199859 [GRCh38]
Chr6:154520993 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_001130700.2(IPCEF1):c.1080C>G (p.Ile360Met) single nucleotide variant not specified [RCV004630917] Chr6:154167944 [GRCh38]
Chr6:154489079 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_001130700.2(IPCEF1):c.508C>G (p.Pro170Ala) single nucleotide variant not specified [RCV004630914] Chr6:154212799 [GRCh38]
Chr6:154533933 [GRCh37]
Chr6:6q25.2
uncertain significance
NM_000914.5(OPRM1):c.112G>T (p.Asp38Tyr) single nucleotide variant not specified [RCV004655213] Chr6:154039656 [GRCh38]
Chr6:154360791 [GRCh37]
Chr6:6q25.2
uncertain significance
NC_000006.11:g.(?_152949380)_(154441965_?)del deletion Autosomal recessive ataxia, Beauce type [RCV004578667] Chr6:152949380..154441965 [GRCh37]
Chr6:6q25.2
pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3761
Count of miRNA genes:1115
Interacting mature miRNAs:1365
Transcripts:ENST00000229768, ENST00000330432, ENST00000337049, ENST00000360422, ENST00000414028, ENST00000419506, ENST00000428397, ENST00000434900, ENST00000435918, ENST00000452687, ENST00000518759, ENST00000519083, ENST00000519613, ENST00000520282, ENST00000520708, ENST00000521106, ENST00000522236, ENST00000522382, ENST00000522555, ENST00000522739, ENST00000523520, ENST00000524150, ENST00000524163
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
406969921GWAS618897_Htrait in response to efavirenz, virologic response measurement QTL GWAS618897 (human)0.000005trait in response to abacavir, virologic response measurement6154131402154131403Human
406899778GWAS548754_Hopioid use disorder QTL GWAS548754 (human)7e-10conditioned place preference behavior trait (VT:0010723)6154039662154039663Human
407067654GWAS716630_Hbody mass index QTL GWAS716630 (human)1e-09body mass indexbody mass index (BMI) (CMO:0000105)6154011812154011813Human
407180352GWAS829328_Hblood protein measurement QTL GWAS829328 (human)8e-17blood protein measurementblood protein measurement (CMO:0000028)6154192279154192280Human
407413455GWAS1062431_Hdiastolic blood pressure QTL GWAS1062431 (human)1e-10diastolic blood pressurediastolic blood pressure (CMO:0000005)6154093311154093312Human
406899720GWAS548696_Hopioid use disorder QTL GWAS548696 (human)1e-10conditioned place preference behavior trait (VT:0010723)6154039662154039663Human
406896009GWAS544985_Hbody surface area QTL GWAS544985 (human)3e-10body surface area6154012048154012049Human
406896585GWAS545561_Hopioid dependence QTL GWAS545561 (human)3e-09opioid dependence6154057088154057089Human
406896586GWAS545562_Hopioid dependence QTL GWAS545562 (human)0.000002opioid dependence6154039662154039663Human
407115016GWAS763992_Hbody mass index QTL GWAS763992 (human)1e-11body mass indexbody mass index (BMI) (CMO:0000105)6154012048154012049Human
406896588GWAS545564_Hopioid dependence QTL GWAS545564 (human)8e-08opioid dependence6154059584154059585Human
406899724GWAS548700_Hopioid use disorder QTL GWAS548700 (human)9e-11conditioned place preference behavior trait (VT:0010723)6154072545154072546Human
406944717GWAS593693_Hidiopathic osteonecrosis of the femoral head QTL GWAS593693 (human)0.000002idiopathic osteonecrosis of the femoral head6154098404154098405Human
407419589GWAS1068565_Hdiastolic blood pressure QTL GWAS1068565 (human)1e-10diastolic blood pressurediastolic blood pressure (CMO:0000005)6154097624154097625Human
407301387GWAS950363_Hdiastolic blood pressure QTL GWAS950363 (human)3e-11diastolic blood pressurediastolic blood pressure (CMO:0000005)6154097624154097625Human
407416710GWAS1065686_Hsystolic blood pressure QTL GWAS1065686 (human)0.000001systolic blood pressuresystolic blood pressure (CMO:0000004)6154097624154097625Human
407163287GWAS812263_Hasthma QTL GWAS812263 (human)0.000008asthma6154156778154156779Human
407285200GWAS934176_Hbody height QTL GWAS934176 (human)3e-19body height (VT:0001253)body height (CMO:0000106)6154062523154062524Human
407199059GWAS848035_Hlipid measurement QTL GWAS848035 (human)0.000004lipid measurementblood lipid measurement (CMO:0000050)6154145997154145998Human
406967254GWAS616230_Hchronic lymphocytic leukemia QTL GWAS616230 (human)4e-08chronic lymphocytic leukemia6154150090154150091Human
406986777GWAS635753_Hbody height QTL GWAS635753 (human)4e-10body height (VT:0001253)body mass index (BMI) (CMO:0000105)6154012048154012049Human
407413779GWAS1062755_Hsystolic blood pressure QTL GWAS1062755 (human)7e-08systolic blood pressuresystolic blood pressure (CMO:0000004)6154093311154093312Human
406923226GWAS572202_Hhypertension QTL GWAS572202 (human)0.000001hypertension6154115101154115102Human
407347996GWAS996972_Htype 2 diabetes mellitus QTL GWAS996972 (human)0.000009type 2 diabetes mellitus6154233115154233116Human
407408148GWAS1057124_Hsystolic blood pressure QTL GWAS1057124 (human)2e-08diastolic blood pressurediastolic blood pressure (CMO:0000005)6154093311154093312Human
407025757GWAS674733_Hhypertension QTL GWAS674733 (human)0.000005hypertension6154093428154093429Human
407303655GWAS952631_Hfat body mass QTL GWAS952631 (human)2e-08body fat mass (VT:0010482)total body fat mass (CMO:0000305)6154012048154012049Human
407316582GWAS965558_Hopioid use disorder QTL GWAS965558 (human)5e-08conditioned place preference behavior trait (VT:0010723)6154039662154039663Human
407316581GWAS965557_Hopioid use disorder QTL GWAS965557 (human)2e-08conditioned place preference behavior trait (VT:0010723)6154057088154057089Human
407316579GWAS965555_Hopioid use disorder QTL GWAS965555 (human)5e-09conditioned place preference behavior trait (VT:0010723)6154039662154039663Human
407223009GWAS871985_Hchronic lymphocytic leukemia QTL GWAS871985 (human)2e-10chronic lymphocytic leukemia6154157305154157306Human
406994859GWAS643835_Hopioid use disorder QTL GWAS643835 (human)8e-10conditioned place preference behavior trait (VT:0010723)6154039662154039663Human
407129396GWAS778372_Hbody mass index QTL GWAS778372 (human)5e-13body mass indexbody mass index (BMI) (CMO:0000105)6154012048154012049Human
407321526GWAS970502_Hbody weight QTL GWAS970502 (human)6e-13body mass (VT:0001259)body weight (CMO:0000012)6154015757154015758Human
406926898GWAS575874_Hhigh density lipoprotein cholesterol measurement QTL GWAS575874 (human)4e-08high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)6154129854154129855Human
407012020GWAS660996_Htestosterone measurement QTL GWAS660996 (human)1e-09testosterone measurementserum testosterone level (CMO:0000568)6154061232154061233Human
407013178GWAS662154_Hbody mass index QTL GWAS662154 (human)3e-12body mass indexbody mass index (BMI) (CMO:0000105)6154012048154012049Human
407220220GWAS869196_Htrauma exposure measurement QTL GWAS869196 (human)0.000002trauma exposure measurement6154118730154118731Human
407332862GWAS981838_HIGF-1 measurement QTL GWAS981838 (human)2e-10IGF-1 measurementblood insulin-like growth factor 1 level (CMO:0001297)6154140687154140688Human
406899771GWAS548747_Hopioid use disorder QTL GWAS548747 (human)3e-13conditioned place preference behavior trait (VT:0010723)6154039662154039663Human
407047864GWAS696840_Hopioid use disorder QTL GWAS696840 (human)2e-08conditioned place preference behavior trait (VT:0010723)6154039662154039663Human
406971258GWAS620234_Hopioid use disorder QTL GWAS620234 (human)7e-09conditioned place preference behavior trait (VT:0010723)6154039662154039663Human
406934207GWAS583183_Hquality of life during menstruation measurement, Fever QTL GWAS583183 (human)2e-08quality of life during menstruation measurement, Fever6154088681154088682Human
406899839GWAS548815_Hopioid use disorder QTL GWAS548815 (human)8e-13conditioned place preference behavior trait (VT:0010723)6154039662154039663Human

Markers in Region
WI-17899  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376154,480,075 - 154,480,208UniSTSGRCh37
Build 366154,521,767 - 154,521,900RGDNCBI36
Celera6155,214,457 - 155,214,590RGD
Cytogenetic Map6q25.2UniSTS
Cytogenetic Map6q24-q25UniSTS
HuRef6152,043,318 - 152,043,451UniSTS
GeneMap99-GB4 RH Map6606.02UniSTS
Whitehead-RH Map6816.5UniSTS
NCBI RH Map61610.7UniSTS
RH46629  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376154,480,185 - 154,480,351UniSTSGRCh37
Build 366154,521,877 - 154,522,043RGDNCBI36
Celera6155,214,567 - 155,214,733RGD
Cytogenetic Map6q25.2UniSTS
Cytogenetic Map6q24-q25UniSTS
HuRef6152,043,428 - 152,043,594UniSTS
GeneMap99-GB4 RH Map6604.11UniSTS
NCBI RH Map61610.7UniSTS
WI-20576  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376154,477,057 - 154,477,319UniSTSGRCh37
Build 366154,518,749 - 154,519,011RGDNCBI36
Celera6155,211,439 - 155,211,701RGD
Cytogenetic Map6q25.2UniSTS
Cytogenetic Map6q24-q25UniSTS
HuRef6152,040,300 - 152,040,562UniSTS
GeneMap99-GB4 RH Map6605.61UniSTS
Whitehead-RH Map6816.5UniSTS
SHGC-84785  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376154,360,777 - 154,361,083UniSTSGRCh37
Build 366154,402,470 - 154,402,776RGDNCBI36
Celera6155,095,239 - 155,095,545RGD
Cytogenetic Map6q24-q25UniSTS
HuRef6151,924,360 - 151,924,666UniSTS
TNG Radiation Hybrid Map675496.0UniSTS
G62475  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376154,488,311 - 154,488,595UniSTSGRCh37
Build 366154,530,003 - 154,530,287RGDNCBI36
Celera6155,222,693 - 155,222,977RGD
Cytogenetic Map6q25.2UniSTS
Cytogenetic Map6q24-q25UniSTS
HuRef6152,051,554 - 152,051,838UniSTS
TNG Radiation Hybrid Map675425.0UniSTS
D6S2185  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376154,477,049 - 154,477,189UniSTSGRCh37
Build 366154,518,741 - 154,518,881RGDNCBI36
Celera6155,211,431 - 155,211,571RGD
Cytogenetic Map6q25.2UniSTS
Cytogenetic Map6q24-q25UniSTS
HuRef6152,040,292 - 152,040,432UniSTS
GeneMap99-GB4 RH Map6604.11UniSTS
OPRM1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376154,412,495 - 154,412,554UniSTSGRCh37
GRCh371439,651,188 - 39,651,358UniSTSGRCh37
Build 361438,720,939 - 38,721,109RGDNCBI36
Celera1419,515,805 - 19,515,975RGD
Celera6155,146,957 - 155,147,016UniSTS
HuRef6151,976,169 - 151,976,228UniSTS
HuRef1419,765,392 - 19,765,562UniSTS
D6S1836  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376154,439,865 - 154,439,965UniSTSGRCh37
Build 366154,481,557 - 154,481,657RGDNCBI36
Celera6155,174,576 - 155,174,676RGD
Cytogenetic Map6q24-q25UniSTS
HuRef6152,003,421 - 152,003,521UniSTS
Stanford-G3 RH Map66134.0UniSTS
GeneMap99-GB4 RH Map6605.82UniSTS
NCBI RH Map61615.9UniSTS
GeneMap99-G3 RH Map66437.0UniSTS
OPRM1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376154,412,495 - 154,412,554UniSTSGRCh37
GRCh371439,651,188 - 39,651,358UniSTSGRCh37
Build 361438,720,939 - 38,721,109RGDNCBI36
Celera1419,515,805 - 19,515,975RGD
Celera6155,146,957 - 155,147,016UniSTS
HuRef6151,976,169 - 151,976,228UniSTS
HuRef1419,765,392 - 19,765,562UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
191 1067 362 280 2852 484 338 49 219 31 302 1217 1052 3 2626 92 757 262 23

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_021208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001008503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001008504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001008505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001145279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001145280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001145281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001145282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001145283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001145284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001145285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001145286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001145287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001285522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001285523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001285524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001285526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001285527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001285528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_104348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_104349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_104350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_104351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011535851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011535853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011535856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011535862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017010903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017010904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017010905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017010906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017010907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047418837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF153500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF547997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH006705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK309655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL132774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL136444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL359850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL445220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY036622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY036623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY195733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY225404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY292290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY292291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY299483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY309001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY309005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY309006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY309007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY309008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY309009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY364230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY364890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY521028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY587764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ680044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF666090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU340241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU340242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU340243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU360599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU362990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU826059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU826060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU826061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU826062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ041290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ041291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ041292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ041293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ041294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ258059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ478709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ478710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ699462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JX914655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC248111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC248112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC248113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC248114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC248115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC248116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles