Dbn1 (drebrin 1) - Rat Genome Database

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Gene: Dbn1 (drebrin 1) Mus musculus
Analyze
Symbol: Dbn1
Name: drebrin 1
RGD ID: 737436
MGI Page MGI
Description: Predicted to enable actin filament binding activity; cytoskeletal motor inhibitor activity; and profilin binding activity. Involved in several processes, including positive regulation of dendritic spine morphogenesis; positive regulation of receptor localization to synapse; and positive regulation of synaptic plasticity. Acts upstream of or within several processes, including cell communication by chemical coupling; cell communication by electrical coupling; and maintenance of protein location in cell. Located in several cellular components, including actin cytoskeleton; gap junction; and growth cone. Is active in several cellular components, including postsynaptic cytosol; postsynaptic density; and postsynaptic membrane. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and retina. Orthologous to human DBN1 (drebrin 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: developmentally-regulated brain protein; drebrin; drebrin A; drebrin E2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391355,621,241 - 55,635,959 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1355,621,242 - 55,635,924 (-)EnsemblGRCm39 Ensembl
GRCm381355,473,428 - 55,488,126 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1355,473,429 - 55,488,111 (-)EnsemblGRCm38mm10GRCm38
MGSCv371355,574,789 - 55,589,437 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361355,483,409 - 55,497,790 (-)NCBIMGSCv36mm8
Celera1356,527,471 - 56,542,117 (-)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1330.06NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-methylcholanthrene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbon nanotube  (EXP)
chlorpyrifos  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dioxygen  (EXP)
diuron  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
flavonoids  (ISO)
furan  (ISO)
gallic acid  (ISO)
gentamycin  (ISO)
glucose  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (EXP)
indole-3-methanol  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
oxaliplatin  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sarin  (ISO)
SB 415286  (ISO)
sevoflurane  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
streptozocin  (ISO)
temozolomide  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
topotecan  (ISO)
triptonide  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament organization  (IDA)
cell communication by chemical coupling  (IMP)
cell communication by electrical coupling  (IMP)
cell differentiation  (IEA)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to X-ray  (ISO)
cytoplasmic sequestering of protein  (ISO)
generation of neurons  (IEP)
in utero embryonic development  (IMP)
lung alveolus development  (ISO)
maintenance of protein location in cell  (IMP)
modulation of inhibitory postsynaptic potential  (ISO)
negative regulation of actin filament bundle assembly  (ISO)
negative regulation of locomotion involved in locomotory behavior  (ISO)
negative regulation of muscle filament sliding  (ISO)
nervous system development  (IEA,ISO)
neural precursor cell proliferation  (IEP)
neuron projection morphogenesis  (IBA)
positive regulation of axon extension  (IBA,ISO)
positive regulation of cell-substrate adhesion  (ISO)
positive regulation of dendritic spine morphogenesis  (IBA,IMP,ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of receptor localization to synapse  (IMP)
positive regulation of substrate adhesion-dependent cell spreading  (ISO)
positive regulation of synaptic plasticity  (IMP)
postsynaptic actin cytoskeleton organization  (IBA,ISO)
prepulse inhibition  (ISO)
regulation of actin filament polymerization  (IBA,ISO)
regulation of filopodium assembly  (ISO)
regulation of postsynaptic density protein 95 clustering  (ISO)
response to activity  (ISO)
response to xenobiotic stimulus  (ISO)
spermatogenesis  (ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal allantois morphology  (IEA)
abnormal brachial plexus formation  (IEA)
abnormal brain internal capsule morphology  (IEA)
abnormal brain white matter morphology  (IEA)
abnormal cervical rib  (IEA)
abnormal chorioallantoic fusion  (IEA)
abnormal coat appearance  (IEA)
abnormal dendritic spine morphology  (IAGP)
abnormal embryo size  (IEA)
abnormal embryo turning  (IEA)
abnormal eye anterior chamber depth  (IEA)
abnormal forebrain morphology  (IEA)
abnormal heart morphology  (IEA)
abnormal hippocampus morphology  (IAGP)
abnormal hypoglossal canal morphology  (IEA)
abnormal liver morphology  (IEA)
abnormal telencephalon morphology  (IEA)
abnormal vertebrae morphology  (IEA)
abnormal Wolffian duct connection  (IEA)
absent hypoglossal canal  (IEA)
absent hypoglossal nerve  (IEA)
decreased body weight  (IEA)
decreased circulating alanine transaminase level  (IEA)
decreased circulating aspartate transaminase level  (IEA)
decreased circulating calcium level  (IEA)
decreased circulating cholesterol level  (IEA)
decreased circulating free fatty acids level  (IEA)
decreased circulating fructosamine level  (IEA)
decreased circulating HDL cholesterol level  (IEA)
decreased circulating LDL cholesterol level  (IEA)
decreased circulating serum albumin level  (IEA)
decreased circulating total protein level  (IEA)
decreased grip strength  (IEA)
decreased mean corpuscular volume  (IEA)
decreased mean platelet volume  (IEA)
decreased total body fat amount  (IEA)
decreased total retina thickness  (IEA)
decreased vertical activity  (IEA)
dilated liver sinusoidal space  (IEA)
enlarged heart  (IEA)
hyperactivity  (IEA)
impaired cued conditioning behavior  (IAGP)
impaired synaptic plasticity  (IAGP)
increased bone mineral content  (IEA)
increased CD8-positive, alpha-beta T cell number  (IEA)
increased circulating alkaline phosphatase level  (IEA)
increased circulating chloride level  (IEA)
increased circulating creatinine level  (IEA)
increased circulating magnesium level  (IEA)
increased circulating phosphate level  (IEA)
increased cornea thickness  (IEA)
increased exploration in new environment  (IEA)
increased fasting circulating glucose level  (IEA)
increased lean body mass  (IEA)
increased leukocyte cell number  (IEA)
increased red blood cell distribution width  (IEA)
no spontaneous movement  (IEA)
preweaning lethality, complete penetrance  (IEA)
preweaning lethality, incomplete penetrance  (IEA)
thin hypoglossal nerve  (IEA)
unresponsive to tactile stimuli  (IEA)
References

References - curated
# Reference Title Reference Citation
1. Chemical and morphological alterations of spines within the hippocampus and entorhinal cortex precede the onset of Alzheimer's disease pathology in double knock-in mice. Aoki C, etal., J Comp Neurol. 2007 Dec 1;505(4):352-62.
2. Differential expression of synaptic proteins in the frontal and temporal cortex of elderly subjects with mild cognitive impairment. Counts SE, etal., J Neuropathol Exp Neurol. 2006 Jun;65(6):592-601.
3. Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer's disease. Harigaya Y, etal., J Neurosci Res. 1996 Jan 1;43(1):87-92.
4. Decreased drebrin mRNA expression in Alzheimer disease: correlation with tau pathology. Julien C, etal., J Neurosci Res. 2008 Aug 1;86(10):2292-302. doi: 10.1002/jnr.21667.
5. Drebrin expression is increased in spinal motoneurons of rats after axotomy. Kobayashi S, etal., Neurosci Lett. 2001 Oct 5;311(3):165-8.
6. Genetic disruption of the alternative splicing of drebrin gene impairs context-dependent fear learning in adulthood. Kojima N, etal., Neuroscience. 2010 Jan 13;165(1):138-50. doi: 10.1016/j.neuroscience.2009.10.016. Epub 2009 Oct 24.
7. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
8. MGDs mouse GO annotations MGD data from the GO Consortium
9. Drebrin immunoreactivity in the striatum of a rat model of levodopa-induced dyskinesia. Nishijima H, etal., Neuropathology. 2013 Aug;33(4):391-6. doi: 10.1111/neup.12009. Epub 2012 Dec 13.
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. [The changes of central nervous synapses after transient cerebral ischemia]. Saruki N, Masui. 1995 Dec;44(12):1639-47.
14. Drebrin A expression is altered after pilocarpine-induced seizures: time course of changes is consistent for a role in the integrity and stability of dendritic spines of hippocampal granule cells. Sbai O, etal., Hippocampus. 2012 Mar;22(3):477-93. doi: 10.1002/hipo.20914. Epub 2011 Jan 14.
15. Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome. Shim KS and Lubec G, Neurosci Lett. 2002 May 24;324(3):209-12.
16. Hippocampal dysregulation of synaptic plasticity-associated proteins with age-related cognitive decline. VanGuilder HD, etal., Neurobiol Dis. 2011 Jul;43(1):201-12. doi: 10.1016/j.nbd.2011.03.012. Epub 2011 Apr 1.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10633083   PMID:10637315   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11991718   PMID:12466851   PMID:12477932   PMID:12761245  
PMID:14610273   PMID:15084279   PMID:15306695   PMID:15345747   PMID:15489334   PMID:15572359   PMID:15648052   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16780834   PMID:16944949  
PMID:17114649   PMID:17559090   PMID:19711416   PMID:20347847   PMID:20600648   PMID:20882566   PMID:21565611   PMID:21677750   PMID:21873635   PMID:22152295   PMID:22404429   PMID:22715045  
PMID:22794259   PMID:22802532   PMID:24194600   PMID:24448406   PMID:24457600   PMID:24637538   PMID:24720729   PMID:24814707   PMID:25058791   PMID:25680957   PMID:25771685   PMID:25865831  
PMID:26056254   PMID:26398943   PMID:26731339   PMID:26970584   PMID:26972007   PMID:27013612   PMID:27626380   PMID:27996060   PMID:28161364   PMID:28185240   PMID:28198431   PMID:28230156  
PMID:28378742   PMID:28398234   PMID:28416666   PMID:28597477   PMID:28634551   PMID:28671696   PMID:28700664   PMID:28706196   PMID:28833685   PMID:28865015   PMID:28865018   PMID:28865029  
PMID:28865032   PMID:29254152   PMID:29518331   PMID:29539633   PMID:29931051   PMID:30068389   PMID:30157441   PMID:30317558   PMID:30333137   PMID:30349460   PMID:30562941   PMID:30625038  
PMID:30700723   PMID:31162944   PMID:31609468   PMID:32046118   PMID:32325033   PMID:32703415   PMID:33414275   PMID:33674568   PMID:33883605   PMID:33896079   PMID:33914863   PMID:35670107  
PMID:36114006   PMID:36293380   PMID:36417873  


Genomics

Comparative Map Data
Dbn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391355,621,241 - 55,635,959 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1355,621,242 - 55,635,924 (-)EnsemblGRCm39 Ensembl
GRCm381355,473,428 - 55,488,126 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1355,473,429 - 55,488,111 (-)EnsemblGRCm38mm10GRCm38
MGSCv371355,574,789 - 55,589,437 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361355,483,409 - 55,497,790 (-)NCBIMGSCv36mm8
Celera1356,527,471 - 56,542,117 (-)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1330.06NCBI
DBN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385177,456,610 - 177,473,634 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5177,456,608 - 177,474,401 (-)EnsemblGRCh38hg38GRCh38
GRCh375176,883,611 - 176,900,635 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365176,816,220 - 176,833,271 (-)NCBINCBI36Build 36hg18NCBI36
Build 345176,816,219 - 176,832,805NCBI
Celera5171,601,010 - 171,618,030 (+)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5171,803,862 - 171,820,946 (-)NCBIHuRef
CHM1_15176,316,642 - 176,333,751 (-)NCBICHM1_1
T2T-CHM13v2.05177,999,656 - 178,023,769 (-)NCBIT2T-CHM13v2.0
Dbn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2179,150,608 - 9,164,982 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,150,659 - 9,164,984 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx179,166,818 - 9,180,807 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01710,696,845 - 10,710,841 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0179,163,206 - 9,177,195 (+)NCBIRnor_WKY
Rnor_6.0179,679,511 - 9,693,878 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,679,628 - 9,693,820 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01711,788,527 - 11,802,863 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41715,194,687 - 15,208,660 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11715,194,686 - 15,208,660 (+)NCBI
Celera179,229,222 - 9,243,194 (+)NCBICelera
Cytogenetic Map17p14NCBI
Dbn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540829,696,266 - 29,705,416 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540829,695,442 - 29,705,417 (-)NCBIChiLan1.0ChiLan1.0
DBN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan15170,680,775 - 170,697,165 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05172,758,316 - 172,774,974 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15179,820,791 - 179,833,546 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5179,820,791 - 179,836,872 (-)Ensemblpanpan1.1panPan2
DBN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1435,899,969 - 35,913,015 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl435,889,392 - 35,912,507 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha435,866,175 - 35,880,615 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0436,265,157 - 36,279,633 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl436,240,908 - 36,279,633 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1436,090,417 - 36,104,899 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0436,276,383 - 36,290,861 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0436,785,850 - 36,800,327 (+)NCBIUU_Cfam_GSD_1.0
Dbn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213122,710,677 - 122,722,558 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365971,735,380 - 1,747,569 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365971,735,589 - 1,751,628 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DBN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl280,479,460 - 80,495,796 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1280,480,603 - 80,495,797 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DBN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12379,468,010 - 79,484,603 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2379,467,647 - 79,484,592 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607510,659,367 - 10,676,337 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dbn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473312,616,423 - 12,632,133 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473312,616,537 - 12,631,967 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dbn1
535 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2093
Count of miRNA genes:598
Interacting mature miRNAs:743
Transcripts:ENSMUST00000021950, ENSMUST00000109921, ENSMUST00000109923, ENSMUST00000124480, ENSMUST00000127867, ENSMUST00000135705, ENSMUST00000139275, ENSMUST00000139516, ENSMUST00000175813
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
1301015Sysbp2_msystolic blood pressure 2 (mouse)Not determined132047761259821605Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
1357591Tesq1_mtestis weight QTL 1 (mouse)Not determined132061551255720517Mouse
4142009Pregq3_mpregnancy QTL 3 (mouse)Not determined132061551272385189Mouse
4142489Ath25_matherosclerosis 25 (mouse)Not determined2583652959836529Mouse
10401111Pgia40_mproteoglycan induced arthritis 40 (mouse)Not determined132791846961918560Mouse
1300710Pcd4ts2_mp-glycoprotein positive CD4 T cell subset 2 (mouse)Not determined132821044262210544Mouse
1357802Vtbt15_mvertebral trabecular bone trait 15 (mouse)Not determined132821737962217515Mouse
10045621Heal21_mwound healing/regeneration 21 (mouse)Not determined132821737962217515Mouse
10755533Chol18_mcholesterol 18 (mouse)133096946764969467Mouse
10755517Chol15_mcholesterol 15 (mouse)133096946764969467Mouse
12738439Twq4_mtestis weight QTL 4 (mouse)133112911065129110Mouse
14696729Kidlq2_mkidney weight, left QTL 2 (mouse)133134473665344736Mouse
1301299Sluc23_msusceptibility to lung cancer 23 (mouse)Not determined133492194368922081Mouse
10412235Scgq5_mspontaneous crescentic glomerulonephritis QTL 5 (mouse)Not determined133606090896239162Mouse
1357587Pfat3_mpredicted fat percentage 3 (mouse)Not determined133610153070101640Mouse
1301734Acsns2_mAngiostrongylus costaricensis nematode susceptibility 2 (mouse)Not determined133610153070101640Mouse
1300561Heal7_mwound healing/regeneration 7 (mouse)Not determined133614482070144904Mouse
1300862Cfbw5_mcystic fibrosis body weight 5 (mouse)Not determined133872035872720517Mouse
1300985Bmd13_mbone mineral density 13 (mouse)Not determined133962924973629397Mouse
1302157Bwem2_mbody weight day 30 males 2 (mouse)Not determined133962924973629397Mouse
1301801Cpfd5_mcerebellum pattern fissures (mouse)Not determined133962924973629397Mouse
15039353Nmrs35_mNAFLD-associated magnetic resonance shift 35 (mouse)134058825374588253Mouse
1300668Pas10_mpulmonary adenoma susceptibility 10 (mouse)Not determined134148904275489158Mouse
4142331Bxs6_mBXSB/MpJ autoimmune nephritis 6 (mouse)Not determined4521044283744746Mouse
10412109Bxs7_mBXSB/MpJ autoimmune nephritis 7 (mouse)Not determined134521044283744746Mouse
26884396Humsd4_mhumerus midshaft diameter 4, 10 week (mouse)134785347673148119Mouse
4142372Moo2_mmodifier of Odc2 (mouse)Not determinedX5031841184318559Mouse
1301666Eae13_msusceptibility to experimental allergic encephalomyelitis 13 (mouse)Not determined135031841184318559Mouse
1300573Elsgp2_melevated serum gp70 2 (mouse)Not determined135061682884617027Mouse
14746975Manh74_mmandible shape 74 (mouse)135247726986477269Mouse
1302073Pgct1_mprimordial germ cell tumor locus 1 (mouse)Not determined135382078387820897Mouse
1357563Bmch6_mbone mechanical trait 6 (mouse)Not determined135538498089385140Mouse

Markers in Region
AW550627  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381355,473,880 - 55,473,997UniSTSGRCm38
MGSCv371355,575,241 - 55,575,358UniSTSGRCm37
Celera1356,527,923 - 56,528,040UniSTS
Cytogenetic Map13B1UniSTS
cM Map1334.0UniSTS
Whitehead/MRC_RH13580.86UniSTS
UniSTS:237020  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381355,473,654 - 55,473,750UniSTSGRCm38
MGSCv371355,575,015 - 55,575,111UniSTSGRCm37
Celera1356,527,697 - 56,527,793UniSTS
Cytogenetic Map13B1UniSTS
cM Map1334.0UniSTS
Dbn1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371355,582,992 - 55,583,558UniSTSGRCm37
Celera1356,535,663 - 56,536,229UniSTS
Cytogenetic Map13B1UniSTS
cM Map1334.0UniSTS
Dbn1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13B1UniSTS
cM Map1334.0UniSTS
Dbn1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381355,481,631 - 55,482,197UniSTSGRCm38
MGSCv371355,582,992 - 55,583,558UniSTSGRCm37
Celera1356,535,663 - 56,536,229UniSTS
Cytogenetic Map13B1UniSTS
cM Map1334.0UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000021950   ⟹   ENSMUSP00000021950
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1355,621,242 - 55,635,924 (-)Ensembl
GRCm38.p6 Ensembl1355,473,429 - 55,488,111 (-)Ensembl
RefSeq Acc Id: ENSMUST00000109921   ⟹   ENSMUSP00000105547
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1355,621,757 - 55,635,874 (-)Ensembl
GRCm38.p6 Ensembl1355,473,944 - 55,488,061 (-)Ensembl
RefSeq Acc Id: ENSMUST00000109923   ⟹   ENSMUSP00000105549
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1355,621,242 - 55,635,924 (-)Ensembl
GRCm38.p6 Ensembl1355,473,429 - 55,488,111 (-)Ensembl
RefSeq Acc Id: ENSMUST00000124480
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1355,629,480 - 55,634,473 (-)Ensembl
GRCm38.p6 Ensembl1355,481,667 - 55,486,660 (-)Ensembl
RefSeq Acc Id: ENSMUST00000127867
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1355,630,093 - 55,631,782 (-)Ensembl
GRCm38.p6 Ensembl1355,482,280 - 55,483,969 (-)Ensembl
RefSeq Acc Id: ENSMUST00000135705
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1355,622,938 - 55,635,879 (-)Ensembl
GRCm38.p6 Ensembl1355,475,125 - 55,488,066 (-)Ensembl
RefSeq Acc Id: ENSMUST00000139275   ⟹   ENSMUSP00000122574
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1355,629,363 - 55,635,446 (-)Ensembl
GRCm38.p6 Ensembl1355,481,550 - 55,487,633 (-)Ensembl
RefSeq Acc Id: ENSMUST00000139516
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1355,629,191 - 55,629,957 (-)Ensembl
GRCm38.p6 Ensembl1355,481,378 - 55,482,144 (-)Ensembl
RefSeq Acc Id: ENSMUST00000175813
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1355,629,213 - 55,630,070 (-)Ensembl
GRCm38.p6 Ensembl1355,481,400 - 55,482,257 (-)Ensembl
RefSeq Acc Id: NM_001177371   ⟹   NP_001170842
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391355,621,241 - 55,635,889 (-)NCBI
GRCm381355,473,428 - 55,488,076 (-)NCBI
MGSCv371355,574,789 - 55,589,437 (-)RGD
Celera1356,527,471 - 56,542,117 (-)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001177372   ⟹   NP_001170843
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391355,621,241 - 55,635,889 (-)NCBI
GRCm381355,473,428 - 55,488,076 (-)NCBI
MGSCv371355,574,789 - 55,589,437 (-)RGD
Celera1356,527,471 - 56,542,117 (-)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_019813   ⟹   NP_062787
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391355,621,241 - 55,635,889 (-)NCBI
GRCm381355,473,428 - 55,488,076 (-)NCBI
MGSCv371355,574,789 - 55,589,437 (-)RGD
Celera1356,527,471 - 56,542,117 (-)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006517305   ⟹   XP_006517368
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391355,621,241 - 55,635,959 (-)NCBI
GRCm381355,473,428 - 55,488,126 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_062787   ⟸   NM_019813
- Peptide Label: isoform 3
- UniProtKB: Q9QXS6 (UniProtKB/Swiss-Prot),   Q3TRK3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001170842   ⟸   NM_001177371
- Peptide Label: isoform 1
- UniProtKB: Q9QXS5 (UniProtKB/Swiss-Prot),   Q9QXS6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001170843   ⟸   NM_001177372
- Peptide Label: isoform 2
- UniProtKB: Q9QXS6 (UniProtKB/Swiss-Prot),   A0A0R4J1E3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006517368   ⟸   XM_006517305
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000122574   ⟸   ENSMUST00000139275
RefSeq Acc Id: ENSMUSP00000105547   ⟸   ENSMUST00000109921
RefSeq Acc Id: ENSMUSP00000105549   ⟸   ENSMUST00000109923
RefSeq Acc Id: ENSMUSP00000021950   ⟸   ENSMUST00000021950
Protein Domains
ADF-H

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QXS6-F1-model_v2 AlphaFold Q9QXS6 1-706 view protein structure

Promoters
RGD ID:8680456
Promoter ID:EPDNEW_M18258
Type:initiation region
Name:Dbn1_1
Description:Mus musculus drebrin 1 , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381355,488,061 - 55,488,121EPDNEW
RGD ID:6823808
Promoter ID:MM_KWN:14244
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   MEF_B6
Transcripts:OTTMUST00000041301
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361355,583,779 - 55,584,279 (-)MPROMDB
RGD ID:6823807
Promoter ID:MM_KWN:14245
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   MEF_B6,   Spleen
Transcripts:OTTMUST00000041300
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361355,584,856 - 55,585,802 (-)MPROMDB
RGD ID:6823803
Promoter ID:MM_KWN:14246
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:MEF_B6
Transcripts:ENSMUST00000109917,   OTTMUST00000041299
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361355,588,306 - 55,588,806 (-)MPROMDB
RGD ID:6823806
Promoter ID:MM_KWN:14247
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:MEF_B4
Transcripts:ENSMUST00000021950,   ENSMUST00000054646,   ENSMUST00000109919,   ENSMUST00000109923,   ENSMUST00000109925,   NM_019813,   OTTMUST00000041294,   OTTMUST00000041298,   UC007QRD.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361355,589,131 - 55,589,631 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1931838 AgrOrtholog
Ensembl Genes ENSMUSG00000034675 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000021950 ENTREZGENE
  ENSMUSP00000021950.9 UniProtKB/Swiss-Prot
  ENSMUSP00000105547 ENTREZGENE
  ENSMUSP00000105547.3 UniProtKB/TrEMBL
  ENSMUSP00000105549 ENTREZGENE
  ENSMUSP00000105549.3 UniProtKB/Swiss-Prot
  ENSMUSP00000122574.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000021950 ENTREZGENE
  ENSMUST00000021950.15 UniProtKB/Swiss-Prot
  ENSMUST00000109921 ENTREZGENE
  ENSMUST00000109921.9 UniProtKB/TrEMBL
  ENSMUST00000109923 ENTREZGENE
  ENSMUST00000109923.9 UniProtKB/Swiss-Prot
  ENSMUST00000139275.8 UniProtKB/TrEMBL
Gene3D-CATH 3.40.20.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ADF-H UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADF-H/Gelsolin-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:56320 UniProtKB/Swiss-Prot
MGD MGI:1931838 ENTREZGENE
NCBI Gene 56320 ENTREZGENE
PANTHER CORTACTIN AND DREBRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10829:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cofilin_ADF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dbn1 PhenoGen
PROSITE ADF_H UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ADF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Actin depolymerizing proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0R4J1E3 ENTREZGENE, UniProtKB/TrEMBL
  DREB_MOUSE UniProtKB/Swiss-Prot
  F7CPL2_MOUSE UniProtKB/TrEMBL
  Q3TRK3 ENTREZGENE, UniProtKB/TrEMBL
  Q9QXS5 ENTREZGENE
  Q9QXS6 ENTREZGENE
UniProt Secondary A2CG16 UniProtKB/Swiss-Prot
  Q3V234 UniProtKB/Swiss-Prot
  Q922X1 UniProtKB/Swiss-Prot
  Q9QXS5 UniProtKB/Swiss-Prot