Gpx3 (glutathione peroxidase 3) - Rat Genome Database

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Gene: Gpx3 (glutathione peroxidase 3) Mus musculus
Analyze
Symbol: Gpx3
Name: glutathione peroxidase 3
RGD ID: 737382
MGI Page MGI
Description: Enables glutathione peroxidase activity. Acts upstream of or within hydrogen peroxide catabolic process. Located in extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including Barrett's esophagus; cerebral infarction; gastrointestinal system cancer (multiple); multiple myeloma; and type 2 diabetes mellitus. Orthologous to human GPX3 (glutathione peroxidase 3).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AA960521; EGP; EGPx; extracellular GPx; GP; GPx; GPx-3; GPx-P; GSHPx-3; GSHPx-P; plasma glutathione peroxidase; plasma GPx
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391154,793,680 - 54,801,213 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1154,793,279 - 54,801,203 (+)EnsemblGRCm39 Ensembl
GRCm381154,902,854 - 54,910,387 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1154,902,453 - 54,910,377 (+)EnsemblGRCm38mm10GRCm38
MGSCv371154,716,355 - 54,723,889 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361154,746,373 - 54,753,800 (+)NCBIMGSCv36mm8
Celera1159,492,255 - 59,499,807 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1132.13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (IEP)
Acute Coronary Syndrome  (ISO)
acute kidney failure  (ISO)
acute myocardial infarction  (ISO)
adenocarcinoma  (ISO)
aortic valve disease  (ISO)
atherosclerosis  (ISO)
Barrett's adenocarcinoma  (ISO)
Barrett's esophagus  (ISO)
Binge Drinking  (ISO)
brain ischemia  (ISO)
Carbon Tetrachloride Poisoning  (ISO)
Cardiac Fibrosis  (ISO)
Cardiomegaly  (ISO)
cardiovascular system disease  (ISO)
Carotid Atherosclerosis  (ISO)
cerebral infarction  (ISO)
cerebral venous thrombosis  (ISO)
cerebrovascular disease  (ISO)
colon cancer  (IMP)
colorectal adenoma  (ISO)
colorectal carcinoma  (ISO)
congenital heart disease  (ISO)
coronary artery disease  (ISO)
depressive disorder  (ISO)
diabetes mellitus  (IDA,IEP)
Diabetic Nephropathies  (ISO)
disease of cellular proliferation  (ISO)
endometrial adenocarcinoma  (ISO)
endometriosis  (ISO)
esophageal cancer  (ISO)
esophagus adenocarcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
familial adenomatous polyposis 1  (ISO)
Fanconi syndrome  (ISO)
gallbladder carcinoma  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
hypoglycemia  (IEP)
Hypoxia  (ISO)
Insulin Resistance  (ISO)
intracranial sinus thrombosis  (ISO)
Kidney Reperfusion Injury  (ISO)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung carcinoma  (IEP)
lung disease  (ISO)
Lung Neoplasms  (ISO)
Lymphatic Metastasis  (ISO)
lymphoplasmacytic lymphoma  (ISO)
male infertility  (ISO)
meningioma  (ISO)
Mercury Poisoning  (ISO)
Metabolic Syndrome  (ISO)
mild pre-eclampsia  (ISO)
multiple myeloma  (ISO)
Myocardial Reperfusion Injury  (ISO)
nasal type extranodal NK/T-cell lymphoma  (ISO)
nephrotic syndrome  (ISO)
nephrotoxicity  (ISO)
neurodegenerative disease  (ISO)
obesity  (IEP,ISO)
Perinatal Asphyxia  (ISO)
polycystic ovary syndrome  (ISO)
Postoperative Atrial Fibrillation  (ISO)
pre-eclampsia  (ISO)
Pregnancy-Induced Hypertension  (ISO)
Primary Graft Dysfunction  (ISO)
Prostatic Neoplasms  (ISO)
Pulmonary Arterial Hypertension  (ISO)
Radiation Injuries  (ISO)
rectum cancer  (ISO)
sciatic neuropathy  (ISO)
severe pre-eclampsia  (ISO)
spermatic cord torsion  (ISO)
Spinal Cord Injuries  (ISO)
stomach cancer  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
Sudden Hearing Loss  (ISO)
systemic scleroderma  (ISO)
transient cerebral ischemia  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Vascular Calcification  (ISO)
vitamin B12 deficiency  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
(E)-cinnamyl alcohol  (ISO)
(R)-lipoic acid  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,10-phenanthroline  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,7-dihydropurine-6-thione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
7,12-dimethyltetraphene  (EXP)
acetamide  (ISO)
acrylonitrile  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
apocynin  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
astaxanthin  (EXP)
atrazine  (EXP)
azathioprine  (ISO)
Azoxymethane  (EXP)
Bandrowski's base  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bifenthrin  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
calcium dichloride  (EXP)
cannabidiol  (ISO)
captan  (EXP)
carbon nanotube  (EXP)
cerium trichloride  (ISO)
chlordecone  (EXP)
chlorobenzene  (ISO)
choline  (EXP)
chromium(6+)  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (EXP)
cinnamyl alcohol  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
cumene  (EXP)
Cuprizon  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cyfluthrin  (ISO)
cylindrospermopsin  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (EXP)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
diclofenac  (EXP)
dieldrin  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (EXP)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP,ISO)
ethanol  (EXP,ISO)
etoposide  (EXP)
eugenol  (ISO)
fenofibrate  (EXP)
flumequine  (EXP)
fluoxetine  (ISO)
flurbiprofen  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
furan  (ISO)
genistein  (EXP)
gentamycin  (ISO)
glyphosate  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
GW 7647  (ISO)
hexachlorobenzene  (ISO)
hydrogen peroxide  (EXP)
ifosfamide  (ISO)
indometacin  (ISO)
inulin  (EXP)
irinotecan  (ISO)
isoeugenol  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
L-methionine  (EXP)
lanthanum trichloride  (ISO)
lead(0)  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (EXP)
lutein  (EXP)
lycopene  (EXP)
medroxyprogesterone acetate  (ISO)
melatonin  (EXP)
mercaptopurine  (ISO)
mercury atom  (EXP)
mercury dibromide  (ISO)
mercury(0)  (EXP)
Mesaconitine  (ISO)
metam  (EXP)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
microcystin-LR  (EXP,ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-acetylsphingosine  (ISO)
N-nitrosodiethylamine  (ISO)
naphthalene  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (EXP)
nitric oxide  (EXP,ISO)
nitrogen dioxide  (ISO)
Nutlin-3  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
oltipraz  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
PhIP  (ISO)
pioglitazone  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP,ISO)
purine-6-thiol  (ISO)
Pyridostigmine bromide  (ISO)
quercetin  (EXP,ISO)
Rebamipide  (ISO)
resveratrol  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
SB 431542  (ISO)
selenium atom  (EXP,ISO)
selenium(2+)  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP)
Soman  (ISO)
streptozocin  (ISO)
sulfasalazine  (EXP)
sulindac  (ISO)
sunitinib  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP)
tetracycline  (EXP)
tetradecane  (ISO)
tetrathiomolybdate(2-)  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trans-isoeugenol  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
troglitazone  (ISO)
tunicamycin  (EXP)
undecane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular space  (HDA,IBA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Proteomic identification of novel differentiation plasma protein markers in hypobaric hypoxia-induced rat model. Ahmad Y, etal., PLoS One. 2014 May 19;9(5):e98027. doi: 10.1371/journal.pone.0098027. eCollection 2014.
2. Screening of the GPX3 gene identifies the "T" allele of the SNP -861A/T as a risk for ischemic stroke in young Asian Indians. Akhter MS, etal., J Stroke Cerebrovasc Dis. 2014 Sep;23(8):2060-2068. doi: 10.1016/j.jstrokecerebrovasdis.2014.03.010. Epub 2014 Aug 8.
3. Epigenetic and Glucocorticoid Receptor-Mediated Regulation of Glutathione Peroxidase 3 in Lung Cancer Cells. An BC, etal., Mol Cells. 2016 Aug 31;39(8):631-8. doi: 10.14348/molcells.2016.0164. Epub 2016 Aug 3.
4. Radioprotective effects of black seed (Nigella sativa) oil against hemopoietic damage and immunosuppression in gamma-irradiated rats. Assayed ME, Immunopharmacol Immunotoxicol. 2010 Jun;32(2):284-96. doi: 10.3109/08923970903307552.
5. Desferrioxamine effectively attenuates testicular tissue at the end of 3 h of ischemia but not in an equal period of reperfusion. Ayvaz S, etal., J Pediatr Urol. 2014 Jun;10(3):550-8. doi: 10.1016/j.jpurol.2013.11.019. Epub 2013 Dec 27.
6. Glutathione peroxidase 3 serum levels and GPX3 gene polymorphisms in subjects with metabolic syndrome. Baez-Duarte BG, etal., Arch Med Res. 2014 Jul;45(5):375-82. doi: 10.1016/j.arcmed.2014.05.001. Epub 2014 May 10.
7. Tumor suppressor function of the plasma glutathione peroxidase gpx3 in colitis-associated carcinoma. Barrett CW, etal., Cancer Res. 2013 Feb 1;73(3):1245-55. doi: 10.1158/0008-5472.CAN-12-3150. Epub 2012 Dec 5.
8. Persistent oxidative stress following renal ischemia-reperfusion injury increases ANG II hemodynamic and fibrotic activity. Basile DP, etal., Am J Physiol Renal Physiol. 2012 Jun 1;302(11):F1494-502. doi: 10.1152/ajprenal.00691.2011. Epub 2012 Mar 21.
9. Cereal based diets modulate some markers of oxidative stress and inflammation in lean and obese Zucker rats. Belobrajdic DP, etal., Nutr Metab (Lond). 2011 May 3;8:27. doi: 10.1186/1743-7075-8-27.
10. Low serum glutathione peroxidase activity is associated with increased cardiovascular mortality in individuals with low HDLc's. Buijsse B, etal., PLoS One. 2012;7(6):e38901. doi: 10.1371/journal.pone.0038901. Epub 2012 Jun 15.
11. Methylation of promoter and expression silencing of GPX3 gene in hepatocellular carcinoma tissue. Cao S, etal., Clin Res Hepatol Gastroenterol. 2015 Apr;39(2):198-204. doi: 10.1016/j.clinre.2014.09.003. Epub 2014 Oct 13.
12. Glutathione peroxidase 3 gene polymorphisms and the risk of sudden sensorineural hearing loss. Chien CY, etal., Kaohsiung J Med Sci. 2017 Jul;33(7):359-364. doi: 10.1016/j.kjms.2017.04.003. Epub 2017 May 9.
13. Glutathione peroxidase 3 mediates the antioxidant effect of peroxisome proliferator-activated receptor gamma in human skeletal muscle cells. Chung SS, etal., Mol Cell Biol. 2009 Jan;29(1):20-30. Epub 2008 Oct 20.
14. Association of combined genetic variations in SOD3, GPX3, PON1, and GSTT1 with hypertension and severity of coronary artery disease. Decharatchakul N, etal., Heart Vessels. 2020 Jul;35(7):918-929. doi: 10.1007/s00380-020-01564-6. Epub 2020 Feb 8.
15. Association of genetic polymorphisms in SOD2, SOD3, GPX3, and GSTT1 with hypertriglyceridemia and low HDL-C level in subjects with high risk of coronary artery disease. Decharatchakul N, etal., PeerJ. 2019 Aug 1;7:e7407. doi: 10.7717/peerj.7407. eCollection 2019.
16. Acute hypoglycemia induces retinal cell death in mouse. Emery M, etal., PLoS One. 2011;6(6):e21586. doi: 10.1371/journal.pone.0021586. Epub 2011 Jun 27.
17. Microarray gene expression profiling in meningiomas: differential expression according to grade or histopathological subtype. Fèvre-Montange M, etal., Int J Oncol. 2009 Dec;35(6):1395-407. doi: 10.3892/ijo_00000457.
18. Baseline glutathione peroxidase activity affects prognosis after acute coronary syndromes. García-Pinilla JM, etal., Tex Heart Inst J. 2008;35(3):262-7.
19. Quantitative proteomics of CSF reveals potential predicted biomarkers for extranodal NK-/T-cell lymphoma of nasal-type with ethmoidal sinus metastasis. Gong Y, etal., Life Sci. 2018 Apr 1;198:94-98. doi: 10.1016/j.lfs.2018.02.035. Epub 2018 Feb 26.
20. Protective Effects of Ammannia baccifera Against CCl4-Induced Oxidative Stress in Rats. Goodla L, etal., Int J Environ Res Public Health. 2019 Apr 23;16(8):1440. doi: 10.3390/ijerph16081440.
21. Gelatinases A and B and Antioxidant Enzyme Activity in the Early Phase of Acute Myocardial Infarction. Gopcevic K, etal., Folia Biol (Praha). 2017;63(1):20-26.
22. Impaired glomerular and tubular antioxidative defense mechanisms in nephrotic syndrome. Granqvist A, etal., Am J Physiol Renal Physiol. 2010 Oct;299(4):F898-904. doi: 10.1152/ajprenal.00124.2010. Epub 2010 Aug 4.
23. Transcriptional Profiling of Normal, Stenotic, and Regurgitant Human Aortic Valves. Greene CL, etal., Genes (Basel). 2020 Jul 14;11(7):789. doi: 10.3390/genes11070789.
24. No association of the plasma glutathione peroxidase (GPx-3) gene with cerebral venous thrombosis in the German population. Grond-Ginsbach C, etal., Stroke. 2009 Feb;40(2):e24; author reply e25. doi: 10.1161/STROKEAHA.108.540062. Epub 2008 Dec 18.
25. Association of tag SNPs of GPx-3 with essential hypertension in rural Han Chinese in Fuxin, Liaoning, China. Hao Y, etal., Chin Med J (Engl). 2011 Jul;124(14):2113-6.
26. Glutathione peroxidase tagSNPs: associations with rectal cancer but not with colon cancer. Haug U, etal., Genes Chromosomes Cancer. 2012 Jun;51(6):598-605. doi: 10.1002/gcc.21946. Epub 2012 Feb 27.
27. NO2-induced acute and chronic lung injury cause imbalance of glutathione metabolism in type II pneumocytes. Hochscheid R, etal., Med Sci Monit. 2005 Aug;11(8):BR273-9. Epub 2005 Jul 25.
28. Glutathione peroxidase activity and expression levels are significantly increased in acute coronary syndromes. Holley A, etal., J Investig Med. 2017 Jun;65(5):919-925. doi: 10.1136/jim-2016-000361. Epub 2017 Mar 15.
29. Expression of Selenoprotein Genes and Association with Selenium Status in Colorectal Adenoma and Colorectal Cancer. Hughes DJ, etal., Nutrients. 2018 Nov 21;10(11). pii: nu10111812. doi: 10.3390/nu10111812.
30. Increased gene expression of glutathione peroxidase-3 in diabetic mouse heart. Iwata K, etal., Biol Pharm Bull. 2006 May;29(5):1042-5.
31. Increased glutathione utilization augments tumor cell proliferation in Waldenstrom Macroglobulinemia. Jalali S, etal., Redox Biol. 2020 Sep;36:101657. doi: 10.1016/j.redox.2020.101657. Epub 2020 Aug 1.
32. Clinical Prognosis for SAH Consistent with Redox Imbalance and Lipid Peroxidation. Jarocka-Karpowicz I, etal., Molecules. 2020 Apr 21;25(8):1921. doi: 10.3390/molecules25081921.
33. Xiaoyao Pills Ameliorate Depression-like Behaviors and Oxidative Stress Induced by Olfactory Bulbectomy in Rats via the Activation of the PIK3CA-AKT1-NFE2L2/BDNF Signaling Pathway. Ji Y, etal., Front Pharmacol. 2021 Apr 15;12:643456. doi: 10.3389/fphar.2021.643456. eCollection 2021.
34. Proteomics analysis of human placenta reveals glutathione metabolism dysfunction as the underlying pathogenesis for preeclampsia. Jin X, etal., Biochim Biophys Acta Proteins Proteom. 2017 Sep;1865(9):1207-1214. doi: 10.1016/j.bbapap.2017.07.003. Epub 2017 Jul 10.
35. High fat feeding and dietary L-arginine supplementation differentially regulate gene expression in rat white adipose tissue. Jobgen W, etal., Amino Acids. 2009 May;37(1):187-98. Epub 2009 Feb 12.
36. Global methylation analysis identifies prognostically important epigenetically inactivated tumor suppressor genes in multiple myeloma. Kaiser MF, etal., Blood. 2013 Jul 11;122(2):219-26. doi: 10.1182/blood-2013-03-487884. Epub 2013 May 22.
37. Resveratrol prevents the development of abdominal aortic aneurysm through attenuation of inflammation, oxidative stress, and neovascularization. Kaneko H, etal., Atherosclerosis. 2011 Aug;217(2):350-7. doi: 10.1016/j.atherosclerosis.2011.03.042. Epub 2011 Apr 8.
38. Gene expression profiling predicts a three-gene expression signature of endometrial adenocarcinoma in a rat model. Karlsson S, etal., Cancer Cell Int. 2009 May 8;9:12.
39. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
40. Plasma glutathione peroxidase deficiency and platelet insensitivity to nitric oxide in children with familial stroke. Kenet G, etal., Arterioscler Thromb Vasc Biol. 1999 Aug;19(8):2017-23. doi: 10.1161/01.atv.19.8.2017.
41. Glutathione Peroxidase 3 as a Biomarker of Recurrence after Lung Cancer Surgery. Kho BG, etal., J Clin Med. 2020 Nov 24;9(12). pii: jcm9123801. doi: 10.3390/jcm9123801.
42. Proteome analysis of serum from type 2 diabetics with nephropathy. Kim HJ, etal., J Proteome Res. 2007 Feb;6(2):735-43.
43. Oxidative stress in perinatal asphyxia. Kumar A, etal., Pediatr Neurol. 2008 Mar;38(3):181-5. doi: 10.1016/j.pediatrneurol.2007.10.008.
44. Biomarker Discovery by Mass Spectrometry in Cerebrospinal Fluid and Plasma after Global Hypoxia-Ischemia in Newborn Piglets. Kyng KJ, etal., Neonatology. 2018;114(4):307-314. doi: 10.1159/000490393. Epub 2018 Jul 19.
45. Cancer-induced Cardiac Atrophy Adversely Affects Myocardial Redox State and Mitochondrial Oxidative Characteristics. Lee DE, etal., JCSM Rapid Commun. 2021 Jan-Jun;4(1):3-15. doi: 10.1002/rco2.18. Epub 2020 Aug 7.
46. Hypermethylation and loss of expression of glutathione peroxidase-3 in Barrett's tumorigenesis. Lee OJ, etal., Neoplasia. 2005 Sep;7(9):854-61. doi: 10.1593/neo.05328.
47. Antioxidant and hepatoprotective activities of Cirsium setidens Nakai against CCl4-induced liver damage. Lee SH, etal., Am J Chin Med. 2008;36(1):107-14.
48. Dysregulation of adipose glutathione peroxidase 3 in obesity contributes to local and systemic oxidative stress. Lee YS, etal., Mol Endocrinol. 2008 Sep;22(9):2176-89. Epub 2008 Jun 18.
49. A Three-Way Interaction among Maternal and Fetal Variants Contributing to Congenital Heart Defects. Li M, etal., Ann Hum Genet. 2016 Jan;80(1):20-31. doi: 10.1111/ahg.12139. Epub 2015 Nov 27.
50. Regulatory effects of sulfur dioxide on the development of atherosclerotic lesions and vascular hydrogen sulfide in atherosclerotic rats. Li W, etal., Atherosclerosis. 2011 Apr;215(2):323-30. doi: 10.1016/j.atherosclerosis.2010.12.037. Epub 2011 Jan 19.
51. Identification of a DNA methylome profile of esophageal squamous cell carcinoma and potential plasma epigenetic biomarkers for early diagnosis. Li X, etal., PLoS One. 2014 Jul 22;9(7):e103162. doi: 10.1371/journal.pone.0103162. eCollection 2014.
52. Preoperative plasma biomarkers associated with atrial fibrillation after coronary artery bypass surgery. Li XY, etal., J Thorac Cardiovasc Surg. 2021 Sep;162(3):851-863.e3. doi: 10.1016/j.jtcvs.2020.01.079. Epub 2020 Feb 19.
53. Gastrodin improves cognitive dysfunction and decreases oxidative stress in vascular dementia rats induced by chronic ischemia. Li Y and Zhang Z, Int J Clin Exp Pathol. 2015 Nov 1;8(11):14099-109. eCollection 2015.
54. Association between glutathione peroxidase-3 activity and carotid atherosclerosis in patients with type 2 diabetes mellitus. Ling P, etal., Brain Behav. 2020 Oct;10(10):e01773. doi: 10.1002/brb3.1773. Epub 2020 Aug 29.
55. Biomarkers for severity of spinal cord injury in the cerebrospinal fluid of rats. Lubieniecka JM, etal., PLoS One. 2011 Apr 29;6(4):e19247. doi: 10.1371/journal.pone.0019247.
56. Selenium alters miRNA profile in an intestinal cell line: evidence that miR-185 regulates expression of GPX2 and SEPSH2. Maciel-Dominguez A, etal., Mol Nutr Food Res. 2013 Dec;57(12):2195-205. doi: 10.1002/mnfr.201300168. Epub 2013 Aug 12.
57. Effects of Heracleum persicum Hydroalcoholic Extract on Insulin, Serum Anti-Oxidant Enzymes, Glucose, and Lipid Profiles in Alloxan-Induced Diabetic Rats. Majidi Z, etal., Iran J Med Sci. 2020 May;45(3):199-206. doi: 10.30476/ijms.2019.45805.
58. Circulating Lipopolysaccharides and Impaired Antioxidant Status in Patients With Atrial Fibrillation. Data From the ATHERO-AF Study. Menichelli D, etal., Front Cardiovasc Med. 2021 Nov 17;8:779503. doi: 10.3389/fcvm.2021.779503. eCollection 2021.
59. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
60. MGDs mouse GO annotations MGD data from the GO Consortium
61. Reduced selenium concentrations and glutathione peroxidase activity in preeclamptic pregnancies. Mistry HD, etal., Hypertension. 2008 Nov;52(5):881-8. doi: 10.1161/HYPERTENSIONAHA.108.116103. Epub 2008 Oct 13.
62. Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy. Mistry HD, etal., Placenta. 2010 May;31(5):401-8. doi: 10.1016/j.placenta.2010.02.011. Epub 2010 Mar 19.
63. Continuous vs interval training on glycemic control and macro- and microvascular reactivity in type 2 diabetic patients. Mitranun W, etal., Scand J Med Sci Sports. 2014 Apr;24(2):e69-76. doi: 10.1111/sms.12112. Epub 2013 Sep 17.
64. The nephroprotection exerted by curcumin in maleate-induced renal damage is associated with decreased mitochondrial fission and autophagy. Molina-Jijón E, etal., Biofactors. 2016 Nov 12;42(6):686-702. doi: 10.1002/biof.1313. Epub 2016 Jul 13.
65. Deferoxamine pretreatment prevents Cr(VI)-induced nephrotoxicity and oxidant stress: role of Cr(VI) chelation. Molina-Jijón E, etal., Toxicology. 2012 Jan 27;291(1-3):93-101. doi: 10.1016/j.tox.2011.11.003. Epub 2011 Nov 15.
66. Mangosteen (Garcinia mangostana) flesh supplementation attenuates biochemical and morphological changes in the liver and kidney of high fat diet-induced obese rats. Muhamad Adyab NS, etal., BMC Complement Altern Med. 2019 Dec 2;19(1):344. doi: 10.1186/s12906-019-2764-5.
67. Selective antioxidant enzymes during ischemia/reperfusion in myocardial infarction. Muzáková V, etal., Physiol Res. 2000;49(3):315-22.
68. Oxidative stress and adhesion molecules in children with type 1 diabetes mellitus: a possible link. Mylona-Karayanni C, etal., Pediatr Diabetes. 2006 Feb;7(1):51-9.
69. Sulforaphane attenuates gentamicin-induced nephrotoxicity: role of mitochondrial protection. Negrette-Guzmán M, etal., Evid Based Complement Alternat Med. 2013;2013:135314. doi: 10.1155/2013/135314. Epub 2013 Apr 4.
70. Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos. Neidhardt L, etal., Mech Dev 2000 Nov;98(1-2):77-94.
71. Plasma glutathione peroxidase in pediatric stroke families. Nowak-Göttl U, etal., J Thromb Haemost. 2011 Jan;9(1):33-8. doi: 10.1111/j.1538-7836.2010.04103.x.
72. Diagnostic value of serum glutathione peroxidase 3 levels in patients with lung cancer. Oh IJ, etal., Thorac Cancer. 2014 Sep;5(5):425-30. doi: 10.1111/1759-7714.12113. Epub 2014 Aug 25.
73. Binge drinking during adolescence disrupts Se homeostasis and its main hepatic selenoprotein expression. Ojeda ML, etal., Alcohol Clin Exp Res. 2015 May;39(5):818-26. doi: 10.1111/acer.12707. Epub 2015 Apr 10.
74. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
75. Aging-Related Decline of Glutathione Peroxidase 3 and Risk of Cardiovascular Events in Patients With Atrial Fibrillation. Pastori D, etal., J Am Heart Assoc. 2016 Sep 8;5(9):e003682. doi: 10.1161/JAHA.116.003682.
76. GPX3 and GSTT1 as biomarkers related to oxidative stress during renal ischemia reperfusion injuries and their relationship with immune infiltration. Pei J, etal., Front Immunol. 2023 Mar 22;14:1136146. doi: 10.3389/fimmu.2023.1136146. eCollection 2023.
77. Does bromocriptine play a role in decreasing oxidative stress for early weaned programmed obesity? Peixoto-Silva N, etal., Life Sci. 2014 Jan 24;95(1):14-21. doi: 10.1016/j.lfs.2013.12.013. Epub 2013 Dec 17.
78. DNA hypermethylation regulates the expression of members of the Mu-class glutathione S-transferases and glutathione peroxidases in Barrett's adenocarcinoma. Peng DF, etal., Gut. 2009 Jan;58(1):5-15. doi: 10.1136/gut.2007.146290. Epub 2008 Jul 29.
79. Silencing of glutathione peroxidase 3 through DNA hypermethylation is associated with lymph node metastasis in gastric carcinomas. Peng DF, etal., PLoS One. 2012;7(10):e46214. doi: 10.1371/journal.pone.0046214. Epub 2012 Oct 10.
80. Vitamin E protection of obesity-enhanced vascular calcification in uremic rats. Peralta-Ramírez A, etal., Am J Physiol Renal Physiol. 2014 Feb 15;306(4):F422-9. doi: 10.1152/ajprenal.00355.2013. Epub 2013 Dec 26.
81. A subtractive gene expression screen suggests a role of transcription factor AP-2 alpha in control of proliferation and differentiation. Pfisterer P, etal., J Biol Chem 2002 Feb 22;277(8):6637-44. Epub 2001 Dec 10.
82. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
83. Clinical significance and therapeutic value of glutathione peroxidase 3 (GPx3) in hepatocellular carcinoma. Qi X, etal., Oncotarget. 2014 Nov 30;5(22):11103-20. doi: 10.18632/oncotarget.2549.
84. The Clinical Significance and Potential Therapeutic Role of GPx3 in Tumor Recurrence after Liver Transplantation. Qi X, etal., Theranostics. 2016 Aug 8;6(11):1934-46. doi: 10.7150/thno.16023. eCollection 2016.
85. Glutathione Peroxidase 3 Delivered by hiPSC-MSCs Ameliorated Hepatic IR Injury via Inhibition of Hepatic Senescence. Qi X, etal., Theranostics. 2018 Jan 1;8(1):212-222. doi: 10.7150/thno.21656. eCollection 2018.
86. Homocysteine and thiol metabolites in vitamin B12 deficiency. Ranganath LR, etal., Clin Sci (Lond). 2001 Jan;100(1):111-6.
87. Mouse MP Annotation Import Pipeline RGD automated import pipeline
88. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
89. Profiling and identification of cerebrospinal fluid proteins in a rat EAE model of multiple sclerosis. Rosenling T, etal., J Proteome Res. 2012 Apr 6;11(4):2048-60. Epub 2012 Feb 23.
90. Depot-specific overexpression of proinflammatory, redox, endothelial cell, and angiogenic genes in epicardial fat adjacent to severe stable coronary atherosclerosis. Sacks HS, etal., Metab Syndr Relat Disord. 2011 Dec;9(6):433-9. doi: 10.1089/met.2011.0024. Epub 2011 Jun 16.
91. The effect of leaf hydroalcoholic extract of Ephedra pachyclada infertility in male rats treated with cyclophosphamide: An experimental study. Saleh S, etal., Int J Reprod Biomed. 2023 May 8;21(4):285-294. doi: 10.18502/ijrm.v21i4.13268. eCollection 2023 May.
92. A DNA methylation-based test for esophageal cancer detection. Salta S, etal., Biomark Res. 2020 Nov 25;8(1):68. doi: 10.1186/s40364-020-00248-7.
93. Diabetes mellitus increases reactive oxygen species production in the thyroid of male rats. Santos MC, etal., Endocrinology. 2013 Mar;154(3):1361-72. doi: 10.1210/en.2012-1930. Epub 2013 Feb 13.
94. Diet-relevant phytochemical intake affects the cardiac AhR and nrf2 transcriptome and reduces heart failure in hypertensive rats. Seymour EM, etal., J Nutr Biochem. 2013 Sep;24(9):1580-6. doi: 10.1016/j.jnutbio.2013.01.008. Epub 2013 Mar 22.
95. Maternal obesity promotes a proinflammatory signature in rat uterus and blastocyst. Shankar K, etal., Endocrinology. 2011 Nov;152(11):4158-70. Epub 2011 Aug 23.
96. Selenium and Copper as Biomarkers for Pulmonary Arterial Hypertension in Systemic Sclerosis. Sun Q, etal., Nutrients. 2020 Jun 25;12(6):1894. doi: 10.3390/nu12061894.
97. Selenium, selenoenzymes, oxidative stress and risk of neoplastic progression from Barrett's esophagus: results from biomarkers and genetic variants. Takata Y, etal., PLoS One. 2012;7(6):e38612. doi: 10.1371/journal.pone.0038612. Epub 2012 Jun 8.
98. Reduced tubular cation transport in diabetes: prevented by ACE inhibition. Thomas MC, etal., Kidney Int. 2003 Jun;63(6):2152-61.
99. Pregnancy-induced hypertension is associated with changes in maternal and umbilical blood antioxidants. Uotila J, etal., Gynecol Obstet Invest. 1993;36(3):153-7. doi: 10.1159/000292616.
100. Findings on lipid peroxidation and antioxidant function in hypertensive complications of pregnancy. Uotila JT, etal., Br J Obstet Gynaecol. 1993 Mar;100(3):270-6. doi: 10.1111/j.1471-0528.1993.tb15242.x.
101. Hypericum perforatum L. supplementation protects sciatic nerve injury-induced apoptotic, inflammatory and oxidative damage to muscle, blood and brain in rats. Uslusoy F, etal., J Pharm Pharmacol. 2019 Jan;71(1):83-92. doi: 10.1111/jphp.12741. Epub 2017 May 16.
102. Decreased plasma thiol antioxidant barrier and selenoproteins as potential biomarkers for ongoing methylmercury intoxication and an individual protective capacity. Usuki F and Fujimura M, Arch Toxicol. 2016 Apr;90(4):917-26. doi: 10.1007/s00204-015-1528-3. Epub 2015 May 16.
103. Promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene: a novel risk factor for arterial ischemic stroke among young adults and children. Voetsch B, etal., Stroke. 2007 Jan;38(1):41-9. doi: 10.1161/01.STR.0000252027.53766.2b. Epub 2006 Nov 22.
104. Role of promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene as a risk factor for cerebral venous thrombosis. Voetsch B, etal., Stroke. 2008 Feb;39(2):303-7. doi: 10.1161/STROKEAHA.107.490094. Epub 2007 Dec 20.
105. Functional glutathione peroxidase 3 polymorphisms associated with increased risk of Taiwanese patients with gastric cancer. Wang JY, etal., Clin Chim Acta. 2010 Oct 9;411(19-20):1432-6. doi: 10.1016/j.cca.2010.05.026. Epub 2010 May 27.
106. Quercetin reduces oxidative stress and inhibits activation of c‑Jun N‑terminal kinase/activator protein‑1 signaling in an experimental mouse model of abdominal aortic aneurysm. Wang L, etal., Mol Med Rep. 2014 Feb;9(2):435-42. doi: 10.3892/mmr.2013.1846. Epub 2013 Dec 6.
107. Suppression subtractive hybridization identified differentially expressed genes in lung adenocarcinoma: ERGIC3 as a novel lung cancer-related gene. Wu M, etal., BMC Cancer. 2013 Feb 1;13:44. doi: 10.1186/1471-2407-13-44.
108. Vitamin D-vitamin D receptor alleviates oxidative stress in ischemic acute kidney injury via upregulating glutathione peroxidase 3. Wu X, etal., FASEB J. 2023 Feb;37(2):e22738. doi: 10.1096/fj.202201400R.
109. Positive ALDH1A3 and negative GPX3 expressions are biomarkers for poor prognosis of gallbladder cancer. Yang ZL, etal., Dis Markers. 2013;35(3):163-72. doi: 10.1155/2013/187043. Epub 2013 Aug 25.
110. Decreased antioxidant activity in hypercholesterolemic children with nephrotic syndrome. Zachwieja J, etal., Med Sci Monit. 2003 Jun;9(6):CR235-9.
111. Association of Antioxidative Enzymes Polymorphisms with Efficacy of Platin and Fluorouracil-Based Adjuvant Therapy in Gastric Cancer. Zhang H, etal., Cell Physiol Biochem. 2018;48(6):2247-2257. doi: 10.1159/000492642. Epub 2018 Aug 16.
112. Pyrroloquinoline Quinone Inhibits Oxidative Stress in Rats with Diabetic Nephropathy. Zhang M, etal., Med Sci Monit. 2020 Jun 27;26:e924372. doi: 10.12659/MSM.924372.
113. The protective effect of melatonin on brain ischemia and reperfusion in rats and humans: In vivo assessment and a randomized controlled trial. Zhao Z, etal., J Pineal Res. 2018 Nov;65(4):e12521. doi: 10.1111/jpi.12521. Epub 2018 Sep 30.
114. GPX3 hypermethylation in gastric cancer and its prognostic value in patients aged over 60. Zhou C, etal., Future Oncol. 2019 Apr;15(11):1279-1289. doi: 10.2217/fon-2018-0674. Epub 2019 Mar 29.
115. Rhamnocitrin Attenuates Ovarian Fibrosis in Rats with Letrozole-Induced Experimental Polycystic Ovary Syndrome. Zhou Y, etal., Oxid Med Cell Longev. 2022 May 26;2022:5558599. doi: 10.1155/2022/5558599. eCollection 2022.
116. GPX3 suppresses tumor migration and invasion via the FAK/AKT pathway in esophageal squamous cell carcinoma. Zhu X, etal., Am J Transl Res. 2018 Jun 15;10(6):1908-1920. eCollection 2018.
Additional References at PubMed
PMID:1339300   PMID:7667255   PMID:7929449   PMID:8566787   PMID:9508085   PMID:9843785   PMID:10349636   PMID:10645275   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11978890  
PMID:12477932   PMID:14681479   PMID:15489334   PMID:15645444   PMID:15947738   PMID:16141072   PMID:16141073   PMID:16445905   PMID:16508038   PMID:16602821   PMID:16682824   PMID:16890189  
PMID:18310450   PMID:20015939   PMID:20405008   PMID:20660060   PMID:21267068   PMID:21308776   PMID:21374652   PMID:21493731   PMID:21518981   PMID:21677750   PMID:21854231   PMID:21873635  
PMID:21948268   PMID:22326323   PMID:23651543   PMID:24006456   PMID:24194600   PMID:24434121   PMID:24631040   PMID:24952961   PMID:25068390   PMID:26816005   PMID:27149259   PMID:27435875  
PMID:27626380   PMID:27689697   PMID:27918237   PMID:28378742   PMID:28677736   PMID:29244159   PMID:29669786   PMID:30135482   PMID:32369454   PMID:32450005   PMID:34292881   PMID:35799890  
PMID:36880685   PMID:38355793  


Genomics

Comparative Map Data
Gpx3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391154,793,680 - 54,801,213 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1154,793,279 - 54,801,203 (+)EnsemblGRCm39 Ensembl
GRCm381154,902,854 - 54,910,387 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1154,902,453 - 54,910,377 (+)EnsemblGRCm38mm10GRCm38
MGSCv371154,716,355 - 54,723,889 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361154,746,373 - 54,753,800 (+)NCBIMGSCv36mm8
Celera1159,492,255 - 59,499,807 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1132.13NCBI
GPX3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385151,020,591 - 151,028,988 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5151,020,591 - 151,028,988 (+)EnsemblGRCh38hg38GRCh38
GRCh375150,400,152 - 150,408,549 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365150,380,192 - 150,388,747 (+)NCBINCBI36Build 36hg18NCBI36
Build 345150,380,111 - 150,388,741NCBI
Celera5146,481,339 - 146,489,894 (+)NCBICelera
Cytogenetic Map5q33.1NCBI
HuRef5145,545,808 - 145,554,363 (+)NCBIHuRef
CHM1_15149,832,791 - 149,841,346 (+)NCBICHM1_1
T2T-CHM13v2.05151,557,070 - 151,565,467 (+)NCBIT2T-CHM13v2.0
Gpx3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81039,529,335 - 39,537,406 (+)NCBIGRCr8
mRatBN7.21039,028,624 - 39,036,695 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1039,028,570 - 39,037,035 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1043,717,089 - 43,725,159 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01043,207,165 - 43,215,235 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01038,710,877 - 38,718,947 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01040,247,436 - 40,255,423 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1040,247,436 - 40,255,422 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01040,019,704 - 40,027,691 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41040,311,094 - 40,319,382 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11040,324,744 - 40,333,004 (+)NCBI
Celera1038,366,821 - 38,374,734 (+)NCBICelera
Cytogenetic Map10q22NCBI
Gpx3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554082,622,741 - 2,629,032 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554082,622,162 - 2,629,088 (-)NCBIChiLan1.0ChiLan1.0
GPX3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24146,252,293 - 146,260,848 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15144,391,889 - 144,400,394 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05146,447,939 - 146,456,476 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15152,450,426 - 152,458,994 (+)NCBIpanpan1.1PanPan1.1panPan2
GPX3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1458,200,671 - 58,209,010 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl458,200,672 - 58,209,010 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha457,952,390 - 57,960,731 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0458,638,793 - 58,647,136 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl458,638,795 - 58,647,137 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1458,456,392 - 58,464,733 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0458,555,078 - 58,563,407 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0459,058,428 - 59,066,768 (-)NCBIUU_Cfam_GSD_1.0
Gpx3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213116,903,260 - 116,911,461 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366473,906,113 - 3,913,498 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366473,904,787 - 3,914,223 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPX3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1671,980,475 - 71,989,026 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11671,980,467 - 71,989,011 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21678,282,309 - 78,290,916 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPX3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12353,576,950 - 53,585,321 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603424,129,632 - 24,138,173 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpx3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473340,957,999 - 40,962,993 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473340,957,895 - 40,963,469 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpx3
184 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:702
Count of miRNA genes:385
Interacting mature miRNAs:434
Transcripts:ENSMUST00000082430, ENSMUST00000125094, ENSMUST00000149324
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
4141084Spqq1_msperm quality QTL 1 (mouse)Not determined5406567063319522Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
4142475Ity2a_mimmunity to S. typhimurium 2a (mouse)Not determined113776858060402716Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
1302186Blmpf2_mbleomycin-induced pulmonary fibrosis 2 (mouse)Not determined115406567067078411Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
4141398Tgq22_mtriglyceride QTL 22 (mouse)Not determined2116340655163406Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
4142148Ckdbp2_mchronic kidney disease blood pressure locus 2 (mouse)Not determined115408094165103841Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112577262659772741Mouse

Markers in Region
AA960521  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381154,909,915 - 54,910,064UniSTSGRCm38
MGSCv371154,723,417 - 54,723,566UniSTSGRCm37
Celera1159,499,335 - 59,499,484UniSTS
Cytogenetic Map11B3-B5UniSTS
Whitehead/MRC_RH11742.3UniSTS
Gpx3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381154,909,447 - 54,909,824UniSTSGRCm38
MGSCv371154,722,949 - 54,723,326UniSTSGRCm37
Celera1159,498,867 - 59,499,244UniSTS
Cytogenetic Map11B3-B5UniSTS
cM Map11 UniSTS
UniSTS:225175  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381154,909,729 - 54,909,883UniSTSGRCm38
MGSCv371154,723,231 - 54,723,385UniSTSGRCm37
Celera1159,499,149 - 59,499,303UniSTS
Cytogenetic Map11B3-B5UniSTS
Gpx3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381154,909,553 - 54,909,625UniSTSGRCm38
MGSCv371154,723,055 - 54,723,127UniSTSGRCm37
Celera1159,498,973 - 59,499,045UniSTS
Cytogenetic Map11B3-B5UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001329860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA062309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI194448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL593846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW319411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC037027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC037134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC049235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG796554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY061328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY100863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY339672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB601893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U13705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X84742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000082430   ⟹   ENSMUSP00000081011
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1154,793,598 - 54,801,203 (+)Ensembl
GRCm38.p6 Ensembl1154,902,772 - 54,910,377 (+)Ensembl
Ensembl Acc Id: ENSMUST00000125094   ⟹   ENSMUSP00000119165
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1154,793,279 - 54,800,402 (+)Ensembl
GRCm38.p6 Ensembl1154,902,453 - 54,909,576 (+)Ensembl
Ensembl Acc Id: ENSMUST00000149324   ⟹   ENSMUSP00000119882
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1154,793,752 - 54,800,360 (+)Ensembl
GRCm38.p6 Ensembl1154,902,926 - 54,909,534 (+)Ensembl
RefSeq Acc Id: NM_001329860   ⟹   NP_001316789
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391154,793,680 - 54,801,213 (+)NCBI
GRCm381154,902,854 - 54,910,387 (+)NCBI
Sequence:
RefSeq Acc Id: NM_008161   ⟹   NP_032187
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391154,793,680 - 54,801,213 (+)NCBI
GRCm381154,902,854 - 54,910,387 (+)NCBI
MGSCv371154,716,355 - 54,723,889 (+)RGD
Celera1159,492,256 - 59,499,802 (+)NCBI
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032187   ⟸   NM_008161
- Peptide Label: isoform 1 precursor
- UniProtKB: Q5XKR0 (UniProtKB/Swiss-Prot),   P46412 (UniProtKB/Swiss-Prot),   A0A1C7ZMZ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001316789   ⟸   NM_001329860
- Peptide Label: isoform 2 precursor
- UniProtKB: A0A1C7ZMZ7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000119165   ⟸   ENSMUST00000125094
Ensembl Acc Id: ENSMUSP00000119882   ⟸   ENSMUST00000149324
Ensembl Acc Id: ENSMUSP00000081011   ⟸   ENSMUST00000082430

Promoters
RGD ID:6821016
Promoter ID:MM_KWN:7464
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Lung
Transcripts:OTTMUST00000014399,   OTTMUST00000014400,   OTTMUST00000014401
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361154,716,151 - 54,716,651 (+)MPROMDB
RGD ID:6848586
Promoter ID:MM_TRO:1501
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung
Transcripts:MTR001253.11.965.3,   MTR001253.11.965.4,   MTR001253.11.965.5,   MTR001253.11.965.6
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361154,722,729 - 54,723,229 (+)MPROMDB
RGD ID:8674676
Promoter ID:EPDNEW_M15369
Type:initiation region
Name:Gpx3_1
Description:Mus musculus glutathione peroxidase 3 , transcript variant 1,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381154,902,926 - 54,902,986EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:105102 AgrOrtholog
Ensembl Genes ENSMUSG00000018339 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000082430 ENTREZGENE
  ENSMUST00000082430.11 UniProtKB/Swiss-Prot
  ENSMUST00000125094.9 UniProtKB/TrEMBL
  ENSMUST00000149324 ENTREZGENE
  ENSMUST00000149324.3 UniProtKB/TrEMBL
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Glutathione_peroxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPX_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPX_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14778 UniProtKB/Swiss-Prot
MGD MGI:105102 ENTREZGENE
NCBI Gene 14778 ENTREZGENE
PANTHER GLUTATHIONE PEROXIDASE 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11592 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GSHPx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gpx3 PhenoGen
PIRSF Glutathion_perox UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS GLUTPROXDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLUTATHIONE_PEROXID_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUTATHIONE_PEROXID_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUTATHIONE_PEROXID_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1C7ZMZ5 ENTREZGENE, UniProtKB/TrEMBL
  A0A1C7ZMZ7 ENTREZGENE, UniProtKB/TrEMBL
  GPX3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q5XKR0 ENTREZGENE
UniProt Secondary Q5XKR0 UniProtKB/Swiss-Prot