Gnrhr (gonadotropin releasing hormone receptor) - Rat Genome Database

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Gene: Gnrhr (gonadotropin releasing hormone receptor) Mus musculus
Analyze
Symbol: Gnrhr
Name: gonadotropin releasing hormone receptor
RGD ID: 737340
MGI Page MGI
Description: Predicted to enable gonadotropin-releasing hormone receptor activity and growth hormone-releasing hormone receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; cellular response to hormone stimulus; and negative regulation of cell population proliferation. Predicted to be active in plasma membrane. Is expressed in several structures, including adenohypophysis; jaw; mandibular process; and ovary. Used to study hypogonadotropic hypogonadism 7 with or without anosmia. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 7 with or without anosmia. Orthologous to human GNRHR (gonadotropin releasing hormone receptor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: gnRH receptor; gnRH-R; gonadotropin-releasing hormone receptor
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39586,328,613 - 86,345,760 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl586,328,613 - 86,345,760 (-)EnsemblGRCm39 Ensembl
GRCm38586,180,754 - 86,197,901 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl586,180,754 - 86,197,901 (-)EnsemblGRCm38mm10GRCm38
MGSCv37586,611,019 - 86,626,895 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36587,256,555 - 87,272,431 (-)NCBIMGSCv36mm8
Celera583,413,347 - 83,430,921 (-)NCBICelera
Cytogenetic Map5E1NCBI
cM Map543.56NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-lipoic acid  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrophenol  (ISO)
2-hydroxypropanoic acid  (ISO)
6-propyl-2-thiouracil  (ISO)
ammonium chloride  (ISO)
ammonium hexachloroplatinate  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buserelin  (ISO)
cadmium dichloride  (ISO)
calcidiol  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chlordecone  (EXP)
chromium(6+)  (ISO)
decabromodiphenyl ether  (ISO)
Deslorelin  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (ISO)
dipentyl phthalate  (ISO)
doxorubicin  (ISO)
equol  (ISO)
ethanol  (ISO)
ethylparaben  (ISO)
flutamide  (ISO)
galaxolide  (ISO)
hexamethylene diisocyanate  (ISO)
isoflavones  (ISO)
lipoic acid  (ISO)
maleic acid  (ISO)
melatonin  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
N-ethyl-N-nitrosourea  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
pentobarbital  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picrotoxin  (ISO)
potassium dichromate  (EXP,ISO)
progesterone  (EXP)
rac-lactic acid  (ISO)
sophoraflavanone B  (ISO)
T-2 toxin  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thimerosal  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptorelin  (EXP)
tunicamycin  (EXP)
vinclozolin  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal anogenital distance  (IAGP)
abnormal circulating hormone level  (IAGP)
abnormal estrous cycle  (IAGP)
abnormal external male genitalia morphology  (IAGP)
abnormal female reproductive system morphology  (IAGP)
abnormal female reproductive system physiology  (IAGP)
abnormal gametogenesis  (IAGP)
abnormal internal female genitalia morphology  (IAGP)
abnormal internal male genitalia morphology  (IAGP)
abnormal Leydig cell morphology  (IAGP)
abnormal luteinizing hormone level  (IAGP)
abnormal male reproductive system morphology  (IAGP)
abnormal ovary morphology  (IAGP)
abnormal ovary physiology  (IAGP)
abnormal ovulation  (IAGP)
abnormal pituitary gland physiology  (IAGP)
abnormal reproductive system morphology  (IAGP)
abnormal reproductive system physiology  (IAGP)
abnormal response to injury  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal sperm flagellum morphology  (IAGP)
abnormal spermatocyte morphology  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal testis morphology  (IAGP)
abnormal testis physiology  (IAGP)
absent corpus luteum  (IAGP)
absent estrous cycle  (IAGP)
absent sperm head  (IAGP)
absent tertiary ovarian follicles  (IAGP)
arrest of male meiosis  (IAGP)
arrest of spermatogenesis  (IAGP)
asthenozoospermia  (IAGP)
constricted vagina orifice  (IAGP)
cryptorchism  (IAGP)
decreased circulating dihydrotestosterone level  (IAGP)
decreased circulating estradiol level  (IAGP)
decreased circulating follicle stimulating hormone level  (IAGP)
decreased circulating gonadotropin level  (IAGP)
decreased circulating luteinizing hormone level  (IAGP)
decreased circulating progesterone level  (IAGP)
decreased circulating testosterone level  (IAGP)
decreased corpora lutea number  (IAGP)
decreased follicle stimulating hormone level  (IAGP)
decreased litter size  (IAGP)
decreased luteinizing hormone level  (IAGP)
decreased male germ cell number  (IAGP)
decreased mature ovarian follicle number  (IAGP)
decreased ovary weight  (IAGP)
decreased ovulation rate  (IAGP)
decreased Sertoli cell number  (IAGP)
decreased tertiary ovarian follicle number  (IAGP)
decreased testis weight  (IAGP)
delayed vaginal opening  (IAGP)
female infertility  (IAGP)
immotile sperm  (IAGP)
impaired ovarian folliculogenesis  (IAGP)
increased atretic ovarian follicle number  (IAGP)
increased body weight  (IAGP)
increased circulating estradiol level  (IAGP)
increased circulating follicle stimulating hormone level  (IAGP)
increased circulating luteinizing hormone level  (IAGP)
increased follicle stimulating hormone level  (IAGP)
increased luteinizing hormone level  (IAGP)
increased ovary weight  (IAGP)
increased tertiary ovarian follicle number  (IAGP)
male infertility  (IAGP)
no abnormal phenotype detected  (IAGP)
oligozoospermia  (IAGP)
prolonged estrous cycle  (IAGP)
prolonged estrus  (IAGP)
prolonged metestrus  (IAGP)
reduced female fertility  (IAGP)
reduced male fertility  (IAGP)
small epididymis  (IAGP)
small gonad  (IAGP)
small male preputial gland  (IAGP)
small ovary  (IAGP)
small penis  (IAGP)
small seminal vesicle  (IAGP)
small seminiferous tubules  (IAGP)
small testis  (IAGP)
teratozoospermia  (IAGP)
thin uterus  (IAGP)
uterus hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Knockdown of Hepatic Gonadotropin-Releasing Hormone by Vivo-Morpholino Decreases Liver Fibrosis in Multidrug Resistance Gene 2 Knockout Mice by Down-Regulation of miR-200b. Kyritsi K, etal., Am J Pathol. 2017 Jul;187(7):1551-1565. doi: 10.1016/j.ajpath.2017.03.013. Epub 2017 May 12.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. Digenic mutations account for variable phenotypes in idiopathic hypogonadotropic hypogonadism. Pitteloud N, etal., J Clin Invest. 2007 Feb;117(2):457-63. Epub 2007 Jan 18.
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1324422   PMID:1328228   PMID:1339279   PMID:7559413   PMID:7647469   PMID:7915716   PMID:7988412   PMID:8002931   PMID:8024703   PMID:8034328   PMID:8954047   PMID:9090387  
PMID:9388186   PMID:9425890   PMID:9593910   PMID:9927328   PMID:10433200   PMID:10433230   PMID:10843805   PMID:11606438   PMID:11807026   PMID:11944940   PMID:12145309   PMID:12444048  
PMID:12477932   PMID:12586760   PMID:12943993   PMID:14654247   PMID:15226417   PMID:15388790   PMID:15625238   PMID:15637149   PMID:15705775   PMID:15886197   PMID:16371589   PMID:16602821  
PMID:16840533   PMID:17698926   PMID:17717072   PMID:17914181   PMID:17928134   PMID:17948256   PMID:18218690   PMID:18252959   PMID:18325995   PMID:18425848   PMID:18439800   PMID:18499748  
PMID:18760324   PMID:19333792   PMID:19812390   PMID:19858197   PMID:20068004   PMID:20068010   PMID:20592162   PMID:20805495   PMID:21153141   PMID:21267068   PMID:21303944   PMID:21596839  
PMID:21677750   PMID:21873635   PMID:21898395   PMID:22893721   PMID:22918878   PMID:23143598   PMID:23340250   PMID:23371388   PMID:23536856   PMID:23632635   PMID:23913446   PMID:24085822  
PMID:24308975   PMID:24324164   PMID:24739304   PMID:25089901   PMID:25105693   PMID:25343272   PMID:25583361   PMID:25915183   PMID:25942106   PMID:27029473   PMID:27569529   PMID:27994055  
PMID:28324107   PMID:28346489   PMID:28911172   PMID:29228137   PMID:29263200   PMID:29300908   PMID:29409045   PMID:29796621   PMID:29800110   PMID:29997285   PMID:30154243   PMID:30364975  
PMID:31270345   PMID:31585440   PMID:31703269   PMID:31724029   PMID:31994829   PMID:32191302   PMID:32270195   PMID:33475143   PMID:33872733   PMID:34090968   PMID:34132158   PMID:34864945  
PMID:34905605   PMID:34910520   PMID:34939930   PMID:35643321   PMID:35957608   PMID:37477898   PMID:37828510   PMID:38348415   PMID:38467682  


Genomics

Comparative Map Data
Gnrhr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39586,328,613 - 86,345,760 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl586,328,613 - 86,345,760 (-)EnsemblGRCm39 Ensembl
GRCm38586,180,754 - 86,197,901 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl586,180,754 - 86,197,901 (-)EnsemblGRCm38mm10GRCm38
MGSCv37586,611,019 - 86,626,895 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36587,256,555 - 87,272,431 (-)NCBIMGSCv36mm8
Celera583,413,347 - 83,430,921 (-)NCBICelera
Cytogenetic Map5E1NCBI
cM Map543.56NCBI
GNRHR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38467,737,118 - 67,754,388 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl467,737,118 - 67,754,388 (-)EnsemblGRCh38hg38GRCh38
GRCh37468,602,836 - 68,620,106 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36468,285,688 - 68,304,399 (-)NCBINCBI36Build 36hg18NCBI36
Build 34468,434,963 - 68,450,570NCBI
Celera466,065,459 - 66,084,171 (-)NCBICelera
Cytogenetic Map4q13.2NCBI
HuRef464,516,278 - 64,534,988 (-)NCBIHuRef
CHM1_1468,640,204 - 68,658,910 (-)NCBICHM1_1
T2T-CHM13v2.0471,180,228 - 71,197,499 (-)NCBIT2T-CHM13v2.0
Gnrhr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81422,211,666 - 22,229,654 (+)NCBIGRCr8
mRatBN7.21421,856,871 - 21,874,861 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1421,856,871 - 21,874,861 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1422,213,471 - 22,231,501 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01423,525,897 - 23,543,927 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01422,056,995 - 22,075,025 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01423,480,462 - 23,498,450 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1423,480,462 - 23,498,450 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01423,384,861 - 23,402,815 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41423,625,135 - 23,656,583 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11423,625,137 - 23,656,250 (+)NCBI
Celera1421,327,308 - 21,348,471 (+)NCBICelera
Cytogenetic Map14p21NCBI
GNRHR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2362,141,365 - 62,155,225 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1462,351,392 - 62,367,764 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0456,295,425 - 56,314,962 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1462,687,474 - 62,706,179 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl462,687,474 - 62,706,167 (+)Ensemblpanpan1.1panPan2
GNRHR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11358,253,112 - 58,266,600 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1358,253,027 - 58,266,705 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1358,168,278 - 58,181,765 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01358,865,514 - 58,878,973 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1358,865,514 - 58,878,973 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11358,590,137 - 58,603,620 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01358,080,483 - 58,093,952 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01359,090,982 - 59,104,477 (-)NCBIUU_Cfam_GSD_1.0
Gnrhr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528518,185,844 - 18,202,017 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936582749,016 - 765,189 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936582749,016 - 765,189 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNRHR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.171,205,294 - 1,225,105 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660661,294,292 - 1,311,901 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gnrhr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247611,216,556 - 1,225,994 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247611,216,501 - 1,231,229 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gnrhr
603 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:839
Count of miRNA genes:458
Interacting mature miRNAs:551
Transcripts:ENSMUST00000031172, ENSMUST00000094654, ENSMUST00000113372
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined32133234100777931Mouse
1301010ahl2_mage related hearing loss 2 (mouse)Not determined56265056896650688Mouse
12910784Pwgrq15_mpost-weaning growth rate QTL 15 (mouse)57717582397658215Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537581488112465722Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
10045972Tir5_mtrypanosome infection response 5 (mouse)Not determined563705442104387065Mouse
4141219W10q16_mweight 10 weeks QTL 16 (mouse)Not determined32133234100777931Mouse
10043962Obq27_mobesity QTL 27 (mouse)Not determined55628565590285655Mouse
12910816Ogrq2_moverall growth rate QTL 2 (mouse)57717582397658215Mouse
1301691Cdcs10_mcytokine deficiency colitis susceptibility 10 (mouse)Not determined576280786110280917Mouse
11041665Lmr24_mleishmaniasis resistance 24 (mouse)552694462107321041Mouse
12738408Lfibq5_mliver fibrosis QTL 5 (mouse)58478385389966041Mouse
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5889069387841837Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
11252124Modvl6_mmodifier of vacuolated lens 6 (mouse)56265056896650688Mouse
1301419Cypr3_mcytokine production 3 (mouse)Not determined581019649115019803Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574460661132528839Mouse
1301843Listr1_mlisteriosis resistance 1 (mouse)Not determined56024608194246203Mouse
10043993Hbnr10_mHeligmosomoides bakeri nematode resistance 10 (mouse)Not determined572418876106419011Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
10401246Bglu13_mblood glucose level 13 (mouse)Not determined579539640113539786Mouse
4141438Skmw13_mskeletal muscle weight 13 (mouse)Not determined576190263110190479Mouse
1301713Dbsty2_mdiabesity 2 (mouse)Not determined576445064110445225Mouse
11041899Lmr24a_mleishmaniasis resistance 24a (mouse)552694462107321041Mouse
10401245Bglu18_mblood glucose level 18 (mouse)Not determined582838468116838597Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
1300931Cocrb6_mcocaine related behavior 6 (mouse)Not determined576445064110445225Mouse
4142317Rgcs1_mretinal ganglion cell susceptible 1 (mouse)Not determined55388334108762627Mouse
1301829Thyls2_mthymic lymphoma susceptibility 2 (mouse)Not determined576445064110445225Mouse
12904740M1fscn2_mmodifier 1 of Fscn2 (mouse)566529661100529661Mouse
10755524Mono1_mmonocyte differential 1 (mouse)580849259114849259Mouse
4142428Modvl1_mmodifier of vacuolated lens 1 (mouse)Not determined6265056896650688Mouse
1357431Cia27_mcollagen induced arthritis 27 (mouse)Not determined575315348120018629Mouse
11040589Lmr3a_mleishmaniasis resistance 3a (mouse)55960280193602980Mouse
11040590Lmr3b_mleishmaniasis resistance 3b (mouse)55960280193602980Mouse
11040591Lmr3c_mleishmaniasis resistance 3c (mouse)55960280193602980Mouse
12904739M2fscn2_mmodifier 2 of FSCN2 (mouse)566529661100529661Mouse
1301243Bmd2_mbone mineral density 2 (mouse)Not determined555388334100455525Mouse
1300986Hdlq2_mHDL QTL 2 (mouse)Not determined576280786110280917Mouse
11049560Lmr24d_mleishmaniasis resistance 24d (mouse)56437487798374996Mouse
13464249Ahl16_mage related hearing loss, early onset 16 (mouse)576445064110445225Mouse
13464248Ahl13_mage related hearing loss, early onset 13 (mouse)55564587489645995Mouse
13464250Ahl15_mage related hearing loss, early onset 15 (mouse)56265056896650688Mouse
11040592Lmr3d_mleishmaniasis resistance 3d (mouse)55960280193602980Mouse
13464247Ahl14_mage related hearing loss, early onset 14 (mouse)56040306294403160Mouse
4141124Dshv2_mdorsal hippocampal volume 2 (mouse)Not determined57531534898019803Mouse
10044005Ahl7_mage related hearing loss 7 (mouse)Not determined55833050292330641Mouse
4141505Chlq14_mcirculating hormone level QTL 14 (mouse)Not determined576280786110280917Mouse
13464242Ahl17_mage related hearing loss, early onset 17 (mouse)582838468116838597Mouse

Markers in Region
L33789  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38586,181,961 - 86,182,115UniSTSGRCm38
MGSCv37586,610,986 - 86,611,140UniSTSGRCm37
Celera583,413,314 - 83,413,468UniSTS
Cytogenetic Map5E1UniSTS
cM Map544.0UniSTS
Whitehead_YAC5 UniSTS
L01119  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38586,182,066 - 86,182,175UniSTSGRCm38
MGSCv37586,611,091 - 86,611,200UniSTSGRCm37
Celera583,413,419 - 83,413,528UniSTS
Cytogenetic Map5E1UniSTS
cM Map544.0UniSTS
Whitehead/MRC_RH51128.29UniSTS
Gnrhr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38586,197,832 - 86,198,133UniSTSGRCm38
MGSCv37586,626,857 - 86,627,158UniSTSGRCm37
Celera583,430,883 - 83,431,184UniSTS
Cytogenetic Map5E1UniSTS
cM Map544.0UniSTS


Sequence


Ensembl Acc Id: ENSMUST00000031172   ⟹   ENSMUSP00000031172
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl586,329,853 - 86,345,729 (-)Ensembl
GRCm38.p6 Ensembl586,181,994 - 86,197,870 (-)Ensembl
Ensembl Acc Id: ENSMUST00000094654   ⟹   ENSMUSP00000092238
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl586,332,415 - 86,345,705 (-)Ensembl
GRCm38.p6 Ensembl586,184,556 - 86,197,846 (-)Ensembl
Ensembl Acc Id: ENSMUST00000113372   ⟹   ENSMUSP00000108999
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl586,328,613 - 86,345,760 (-)Ensembl
GRCm38.p6 Ensembl586,180,754 - 86,197,901 (-)Ensembl
RefSeq Acc Id: NM_001310651   ⟹   NP_001297580
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39586,328,613 - 86,345,760 (-)NCBI
GRCm38586,180,754 - 86,197,901 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001310653   ⟹   NP_001297582
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39586,332,417 - 86,345,760 (-)NCBI
GRCm38586,184,558 - 86,197,901 (-)NCBI
Sequence:
RefSeq Acc Id: NM_010323   ⟹   NP_034453
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39586,328,613 - 86,345,760 (-)NCBI
GRCm38586,180,754 - 86,197,901 (-)NCBI
MGSCv37586,611,019 - 86,626,895 (-)RGD
Celera583,413,347 - 83,430,921 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017320667   ⟹   XP_017176156
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39586,330,169 - 86,345,684 (-)NCBI
GRCm38586,182,310 - 86,197,825 (-)NCBI
Sequence:
RefSeq Acc Id: NP_034453   ⟸   NM_010323
- Peptide Label: isoform 1
- UniProtKB: Q61611 (UniProtKB/Swiss-Prot),   Q01776 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001297580   ⟸   NM_001310651
- Peptide Label: isoform 2
- UniProtKB: D3Z6P7 (UniProtKB/TrEMBL),   A0A192B0U8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017176156   ⟸   XM_017320667
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001297582   ⟸   NM_001310653
- Peptide Label: isoform 3
- UniProtKB: Q6P8H4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000031172   ⟸   ENSMUST00000031172
Ensembl Acc Id: ENSMUSP00000108999   ⟸   ENSMUST00000113372
Ensembl Acc Id: ENSMUSP00000092238   ⟸   ENSMUST00000094654
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q01776-F1-model_v2 AlphaFold Q01776 1-327 view protein structure

Promoters
RGD ID:6887010
Promoter ID:EPDNEW_M6954
Type:initiation region
Name:Gnrhr_1
Description:Mus musculus gonadotropin releasing hormone receptor , transcriptvariant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38586,197,887 - 86,197,947EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95790 AgrOrtholog
Ensembl Genes ENSMUSG00000029255 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000031172 ENTREZGENE
  ENSMUST00000031172.9 UniProtKB/Swiss-Prot
  ENSMUST00000094654 ENTREZGENE
  ENSMUST00000094654.3 UniProtKB/TrEMBL
  ENSMUST00000113372 ENTREZGENE
  ENSMUST00000113372.2 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GphnRH_fam_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14715 UniProtKB/Swiss-Prot
MGD MGI:95790 ENTREZGENE
NCBI Gene 14715 ENTREZGENE
PANTHER GONADOTROPIN-RELEASING HORMONE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gnrhr PhenoGen
PRINTS GNADOTRPHINR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A192B0U8 ENTREZGENE, UniProtKB/TrEMBL
  D3Z6P7 ENTREZGENE, UniProtKB/TrEMBL
  GNRHR_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q61611 ENTREZGENE
  Q6P8H4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q61611 UniProtKB/Swiss-Prot