Prg2 (proteoglycan 2, bone marrow) - Rat Genome Database

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Gene: Prg2 (proteoglycan 2, bone marrow) Mus musculus
Analyze
Symbol: Prg2
Name: proteoglycan 2, bone marrow
RGD ID: 737333
MGI Page MGI
Description: Predicted to enable carbohydrate binding activity. Predicted to be an extracellular matrix structural constituent conferring compression resistance. Acts upstream of or within defense response to nematode and regulation of cytokine production. Located in collagen-containing extracellular matrix. Is expressed in several structures, including immune system; liver; lung; and male reproductive gland or organ. Orthologous to human PRG2 (proteoglycan 2, pro eosinophil major basic protein).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BMPG; bone marrow proteoglycan; EMB; EMBP; major basic protein 1; MBP; MGC130327; mMB; mMBP; mMBP-; mMBP-1
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39284,810,805 - 84,813,977 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl284,810,805 - 84,813,976 (+)EnsemblGRCm39 Ensembl
GRCm38284,980,461 - 84,983,632 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl284,980,461 - 84,983,632 (+)EnsemblGRCm38mm10GRCm38
MGSCv37284,820,618 - 84,823,789 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36284,781,300 - 84,784,471 (+)NCBIMGSCv36mm8
Celera286,579,143 - 86,582,324 (+)NCBICelera
Cytogenetic Map2DNCBI
cM Map249.45NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Eosinophils are important for protection, immunoregulation and pathology during infection with nematode microfilariae. Cadman ET, etal., PLoS Pathog. 2014 Mar 13;10(3):e1003988. doi: 10.1371/journal.ppat.1003988. eCollection 2014 Mar.
2. Eosinophil major basic protein-1 does not contribute to allergen-induced airway pathologies in mouse models of asthma. Denzler KL, etal., J Immunol. 2000 Nov 15;165(10):5509-17.
3. Alterations in Placental Gene Expression of Pregnant Women with Chronic Chagas Disease. Juiz NA, etal., Am J Pathol. 2018 Jun;188(6):1345-1353. doi: 10.1016/j.ajpath.2018.02.011. Epub 2018 Mar 12.
4. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
5. Eosinophil degranulation is more important than eosinophilia in identifying asthma in chronic cough. Kim CK, etal., J Asthma. 2011 Dec;48(10):994-1000. doi: 10.3109/02770903.2011.623335. Epub 2011 Oct 24.
6. [Expression of eosinophil major basic protein mRNA in bronchial asthma]. Li SH, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2006 Sep;26(9):1330-3.
7. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
8. MGDs mouse GO annotations MGD data from the GO Consortium
9. MGD IEA MGD IEA
10. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. Mouse MP Annotation Import Pipeline RGD automated import pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Interferon gene expression in sputum cells correlates with the Asthma Index Score during virus-induced exacerbations. Schwantes EA, etal., Clin Exp Allergy. 2014 Jun;44(6):813-21. doi: 10.1111/cea.12269.
15. Peritoneal carcinomatosis of colorectal cancer is characterized by structural and functional reorganization of the tumor microenvironment inducing senescence and proliferation arrest in cancer cells. Seebauer CT, etal., Oncoimmunology. 2016 Oct 14;5(12):e1242543. doi: 10.1080/2162402X.2016.1242543. eCollection 2016.
Additional References at PubMed
PMID:7673718   PMID:9107694   PMID:10349636   PMID:10770291   PMID:11042159   PMID:11076861   PMID:11170744   PMID:12477932   PMID:15100311   PMID:16141072   PMID:16141073   PMID:16227527  
PMID:16299347   PMID:16537572   PMID:16926417   PMID:18430716   PMID:21267068   PMID:21482685   PMID:22131328   PMID:23736699   PMID:24194600   PMID:26147683   PMID:26743624   PMID:27480124  
PMID:27641493   PMID:28071719   PMID:28378742   PMID:28515227   PMID:30619361   PMID:31481482   PMID:31722215   PMID:34616019   PMID:37883230   PMID:38355793  


Genomics

Comparative Map Data
Prg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39284,810,805 - 84,813,977 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl284,810,805 - 84,813,976 (+)EnsemblGRCm39 Ensembl
GRCm38284,980,461 - 84,983,632 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl284,980,461 - 84,983,632 (+)EnsemblGRCm38mm10GRCm38
MGSCv37284,820,618 - 84,823,789 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36284,781,300 - 84,784,471 (+)NCBIMGSCv36mm8
Celera286,579,143 - 86,582,324 (+)NCBICelera
Cytogenetic Map2DNCBI
cM Map249.45NCBI
PRG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381157,386,780 - 57,390,650 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1157,386,780 - 57,390,650 (-)EnsemblGRCh38hg38GRCh38
GRCh371157,154,253 - 57,158,123 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361156,911,410 - 56,914,706 (-)NCBINCBI36Build 36hg18NCBI36
Build 341156,911,410 - 56,914,706NCBI
Celera1154,511,420 - 54,514,715 (-)NCBICelera
Cytogenetic Map11q12.1NCBI
HuRef1153,504,113 - 53,507,408 (-)NCBIHuRef
CHM1_11157,020,853 - 57,024,149 (-)NCBICHM1_1
T2T-CHM13v2.01157,336,805 - 57,340,674 (-)NCBIT2T-CHM13v2.0
Prg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8390,469,192 - 90,472,759 (+)NCBIGRCr8
mRatBN7.2370,062,535 - 70,066,102 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl370,062,535 - 70,066,101 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx373,444,448 - 73,448,007 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0382,043,123 - 82,046,682 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0379,801,564 - 79,805,137 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0372,385,678 - 72,389,245 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl372,385,666 - 72,389,276 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0378,895,715 - 78,899,282 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4368,209,731 - 68,213,293 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1368,106,102 - 68,109,669 (+)NCBI
Celera369,413,529 - 69,417,096 (+)NCBICelera
Cytogenetic Map3q24NCBI
PRG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2958,543,286 - 58,547,177 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11159,560,838 - 59,564,163 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01152,628,289 - 52,631,634 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13160,118,686 - 160,122,041 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3160,118,111 - 160,122,002 (-)Ensemblpanpan1.1panPan2
LOC102156778
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11838,753,269 - 38,760,730 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1838,303,196 - 38,306,317 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01839,438,926 - 39,442,046 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11839,021,552 - 39,024,671 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01838,595,057 - 38,598,175 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01839,225,795 - 39,228,916 (+)NCBIUU_Cfam_GSD_1.0
Prg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494714,987,025 - 14,989,758 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365815,100,623 - 5,102,857 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365815,101,041 - 5,103,175 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1115,850,181 - 15,854,511 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl115,850,913 - 15,854,517 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038113,195,782 - 113,199,106 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Prg2
161 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:185
Count of miRNA genes:177
Interacting mature miRNAs:180
Transcripts:ENSMUST00000028467
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13464141Hbbcq3_mhemoglobin concentration QTL 3 (mouse)25244801986448136Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)261830344136841920Mouse
1300761Lgth1_mbody length 1 (mouse)Not determined25170327685703425Mouse
11528549Sluc31_msusceptibility to lung cancer 31 (mouse)274524117129213005Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31214567105143570Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
1301405Etohr_methanol response acute (mouse)Not determined26300595497006113Mouse
1301660Iba1_minduction of brown adipocytes 1 (mouse)Not determined267647887101648142Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1301703Bomd3_mbone mineral density 3 (mouse)Not determined26300595497006113Mouse
1300875Taste1_mtaste-saccharin preference 1 (mouse)Not determined25092317584923278Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284013198148522175Mouse
1357577Trmq3_mT cell ratio modifier QTL 3 (mouse)Not determined260520612119355518Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
4141406Alpq2_malcohol preference QTL 2 (mouse)Not determined25752411791524288Mouse
10755526Lymph1_mlymphocyte differential 1 (mouse)25081931484819314Mouse
13463471Hctq6_mhematocrit QTL 6 (mouse)25244801986448136Mouse
1301873Hsl1_mhyperoxia susceptibility locus 1 (mouse)Not determined26357015497570301Mouse
1558901Skmw8_mskeletal muscle weight 8 (mouse)Not determined284008488118008593Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1300662Etohila_methanol induced locomotor activity (mouse)Not determined26300595497006113Mouse
1301109Dntcs2_mdental caries susceptibility 2 (mouse)Not determined240885493114910165Mouse
4141657Mohg1_mmodifier of hg 1 (mouse)Not determined276678758103095823Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
10053681Lith24_mlithogenic gene 24 (mouse)Not determined26300595497006113Mouse
1301882Etohc2_methanol consumption 2 (mouse)Not determined268724269102724407Mouse
1301048Actre2_mactivity response to ethanol 2 (mouse)Not determined26300595497006113Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284013198148667470Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
1301374Cplaq7_mcircadian period of locomotor activity 7 (mouse)Not determined276421483110421651Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
1301948Elsgp3_melevated serum gp70 3 (mouse)Not determined268724269102724407Mouse
10043894Bw22_mbody weight QTL 22 (mouse)Not determined280895334114895334Mouse
15092054Egrme5_mearly growth rate, maternal effect 5 (mouse)282190187118004745Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
13463482Mchq17_mmean corpuscular hemoglobin QTL 17 (mouse)267647887101648142Mouse
4142088Parms1_mpatched associated RMS 1 (mouse)Not determined74524117114123532Mouse
10044002Hdl7_mHDL level 7 (mouse)Not determined26300595497006113Mouse
12738429Lfibq18_mliver fibrosis QTL 18 (mouse)25791999191919991Mouse

Markers in Region
Prg2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38284,982,251 - 84,983,204UniSTSGRCm38
MGSCv37284,822,408 - 84,823,361UniSTSGRCm37
Celera286,580,943 - 86,581,896UniSTS
Cytogenetic Map2DUniSTS
cM Map250.0UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000028467   ⟹   ENSMUSP00000028467
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl284,810,805 - 84,813,976 (+)Ensembl
GRCm38.p6 Ensembl284,980,461 - 84,983,632 (+)Ensembl
RefSeq Acc Id: NM_008920   ⟹   NP_032946
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39284,810,805 - 84,813,976 (+)NCBI
GRCm38284,980,461 - 84,983,632 (+)ENTREZGENE
MGSCv37284,820,618 - 84,823,789 (+)RGD
Celera286,579,143 - 86,582,324 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036159620   ⟹   XP_036015513
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39284,810,917 - 84,813,977 (+)NCBI
Sequence:
RefSeq Acc Id: NP_032946   ⟸   NM_008920
- Peptide Label: precursor
- UniProtKB: Q61878 (UniProtKB/Swiss-Prot),   Q545D8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000028467   ⟸   ENSMUST00000028467
RefSeq Acc Id: XP_036015513   ⟸   XM_036159620
- Peptide Label: isoform X1
- UniProtKB: Q61878 (UniProtKB/Swiss-Prot),   Q545D8 (UniProtKB/TrEMBL)
Protein Domains
C-type lectin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61878-F1-model_v2 AlphaFold Q61878 1-223 view protein structure

Promoters
RGD ID:6877820
Promoter ID:EPDNEW_M2361
Type:single initiation site
Name:Prg2_1
Description:Mus musculus proteoglycan 2, bone marrow , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38284,980,460 - 84,980,520EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:103294 AgrOrtholog
Ensembl Genes ENSMUSG00000027073 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000028467 ENTREZGENE
  ENSMUST00000028467.6 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EMBP_CTLD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Eosinophil_major_basic UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19074 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:103294 ENTREZGENE
NCBI Gene 19074 ENTREZGENE
PANTHER BONE MARROW PROTEOGLYCAN UniProtKB/Swiss-Prot
  BONE MARROW PROTEOGLYCAN UniProtKB/Swiss-Prot
  BONE MARROW PROTEOGLYCAN UniProtKB/TrEMBL
  BONE MARROW PROTEOGLYCAN UniProtKB/TrEMBL
Pfam Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prg2 PhenoGen
PRINTS EMAJORBASICP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt PRG2_MOUSE UniProtKB/Swiss-Prot
  Q545D8 ENTREZGENE, UniProtKB/TrEMBL
  Q61878 ENTREZGENE