Aqp6 (aquaporin 6) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Aqp6 (aquaporin 6) Mus musculus
Analyze
Symbol: Aqp6
Name: aquaporin 6
RGD ID: 737144
MGI Page MGI
Description: Predicted to enable nitrate transmembrane transporter activity and water channel activity. Predicted to be involved in carbon dioxide transport; nitrate transmembrane transport; and renal water transport. Predicted to be located in cytoplasmic vesicle membrane. Predicted to be active in apical plasma membrane. Is expressed in cecum; early conceptus; gonad; and metanephros. Orthologous to human AQP6 (aquaporin 6).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI790337; AQP-6; aquaporin-6
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391599,495,891 - 99,503,359 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1599,499,281 - 99,503,358 (+)EnsemblGRCm39 Ensembl
GRCm381599,598,468 - 99,605,478 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1599,601,400 - 99,605,477 (+)EnsemblGRCm38mm10GRCm38
MGSCv371599,431,831 - 99,435,908 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361599,429,434 - 99,433,511 (+)NCBIMGSCv36mm8
Celera15101,756,793 - 101,760,851 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Aquaporins in the kidney. Kwon TH, etal., Handb Exp Pharmacol. 2009;(190):95-132. doi: 10.1007/978-3-540-79885-9_5.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:9757370   PMID:10232700   PMID:10337625   PMID:10349636   PMID:10788316   PMID:11042159   PMID:11066060   PMID:11076861   PMID:11217851   PMID:12031518   PMID:12477932  
PMID:16141072   PMID:16141073   PMID:17112474   PMID:17409310   PMID:19336226   PMID:19367412   PMID:19521566   PMID:20111742   PMID:20224221   PMID:20944551   PMID:21873635   PMID:24194600  
PMID:25516972   PMID:26847765   PMID:27626380   PMID:34540996   PMID:38355793  


Genomics

Comparative Map Data
Aqp6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391599,495,891 - 99,503,359 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1599,499,281 - 99,503,358 (+)EnsemblGRCm39 Ensembl
GRCm381599,598,468 - 99,605,478 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1599,601,400 - 99,605,477 (+)EnsemblGRCm38mm10GRCm38
MGSCv371599,431,831 - 99,435,908 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361599,429,434 - 99,433,511 (+)NCBIMGSCv36mm8
Celera15101,756,793 - 101,760,851 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.13NCBI
AQP6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381249,972,947 - 49,977,139 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1249,967,194 - 49,977,139 (+)EnsemblGRCh38hg38GRCh38
GRCh371250,366,730 - 50,370,922 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361248,652,887 - 48,657,189 (+)NCBINCBI36Build 36hg18NCBI36
Build 341248,652,891 - 48,657,189NCBI
Celera1249,162,741 - 49,167,043 (+)NCBICelera
Cytogenetic Map12q13.12NCBI
HuRef1247,398,122 - 47,402,424 (+)NCBIHuRef
CHM1_11250,332,778 - 50,337,080 (+)NCBICHM1_1
T2T-CHM13v2.01249,935,958 - 49,940,150 (+)NCBIT2T-CHM13v2.0
Aqp6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87132,611,069 - 132,614,004 (+)NCBIGRCr8
mRatBN7.27130,732,216 - 130,735,149 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7130,633,579 - 130,735,194 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl7130,633,579 - 130,735,194 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7132,535,805 - 132,538,735 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07134,761,384 - 134,764,315 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07134,673,911 - 134,676,841 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07141,258,585 - 141,261,518 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7141,258,584 - 141,261,735 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X115,763,288 - 115,766,221 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47138,347,266 - 138,350,199 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17138,423,702 - 138,426,636 (+)NCBI
Celera7127,213,574 - 127,216,507 (+)NCBICelera
Cytogenetic Map7q36NCBI
Aqp6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955547567,152 - 571,895 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955547567,152 - 570,880 (+)NCBIChiLan1.0ChiLan1.0
AQP6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21044,172,566 - 44,216,164 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11244,169,328 - 44,212,932 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01238,739,047 - 38,782,659 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11239,672,067 - 39,676,636 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1239,672,067 - 39,676,636 (-)Ensemblpanpan1.1panPan2
AQP6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1274,727,732 - 4,731,828 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl274,727,725 - 4,731,316 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2741,527,817 - 41,531,698 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0274,775,594 - 4,779,476 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl274,776,786 - 4,789,859 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1274,740,579 - 4,744,460 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0274,730,402 - 4,734,285 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02741,922,470 - 41,926,347 (+)NCBIUU_Cfam_GSD_1.0
Aqp6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494565,511,431 - 65,514,075 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365127,650,724 - 7,653,274 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365127,650,755 - 7,653,399 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AQP6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl515,887,966 - 15,890,805 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1515,888,080 - 15,892,113 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2516,068,162 - 16,071,435 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AQP6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11146,199,907 - 46,207,010 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037199,914,619 - 199,919,218 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aqp6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248162,316,668 - 2,319,650 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248162,314,660 - 2,319,649 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aqp6
228 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:497
Count of miRNA genes:283
Interacting mature miRNAs:297
Transcripts:ENSMUST00000023754
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156129481100797881Mouse
1300627Sluc26_msusceptibility to lung cancer 26 (mouse)Not determined1570345653104073951Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402203102896555Mouse
11528547Sluc34_msusceptibility to lung cancer 34 (mouse)1597884933102896555Mouse
1301918Skull22_mskull morphology 22 (mouse)Not determined1585901546104073951Mouse
14928306Manh79_mmandible shape 79 (mouse)1578847557104073951Mouse
1357894Epfpq3_mepididymal fat percentage QTL 3 (mouse)Not determined1578601103102901704Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800146102008435Mouse
4142060W3q6_mweight 3 weeks QTL 6 (mouse)Not determined78601103102901704Mouse
12791003Aath8_maortic arch atherosclerosis 8 (mouse)1573430144104073951Mouse
11530038Sluc34b_msusceptibility to lung cancer 34b (mouse)1585896437104073951Mouse
11530037Sluc34a_msusceptibility to lung cancer 34a (mouse)1585896437104073951Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578416103425899Mouse
4141921Pstc3_mperiosteal circumference 3 (mouse)Not determined1567270698101270847Mouse
12880411V125Dq11_mvitamin D active form serum level QTL 11 (mouse)1578897881104073951Mouse
1301171Brm2_mbrachyury modifier 2 (mouse)Not determined156552537699525499Mouse
1300851Heal4_mwound healing/regeneration 4 (mouse)Not determined1577527592104073951Mouse
14747011Mancz13_mmandible centroid size 13 (mouse)1572382669104073951Mouse
10402490Dipa5_mdrug induced psychomotor activation 5 (mouse)Not determined1579163411104073951Mouse
1300726Pitm4_mprion incubation time 4 (mouse)Not determined1570349271104073951Mouse
1302197Bhr2_mbronchial hyperresponsiveness 2 (mouse)Not determined1564306334103425899Mouse
1302074Bmd4_mbone mineral density 4 (mouse)Not determined1556186708103425899Mouse
4141902Cia37_mcollagen induced arthritis 37 (mouse)Not determined1580884933104073951Mouse
14700689Carg5_mCandida albicans resistance gene 5 (mouse)1597697881103008427Mouse
4141581Dshv1_mdorsal hippocampal volume 1 (mouse)Not determined92788640103425899Mouse
26884399Humsd1_mhumerus midshaft diameter 1, 5 week (mouse)1548363396101708435Mouse
4141897Imrfq2_mimmune response to Factor IX QTL 2 (mouse)Not determined79908940104073951Mouse
1301284Cosz3_mcocaine seizure 3 (mouse)Not determined1580313634104073951Mouse
4141511Gdcr1_mglycerolphosphate dehydrogenase regulator 1 (mouse)Not determined82615474104073951Mouse
1357614Bmca_mbile mucin accumulation (mouse)Not determined1585896437104073951Mouse
1300648Dbsty4_mdiabesity 4 (mouse)Not determined1570349271104073951Mouse
1300974Pgia9_mproteoglycan induced arthritis 9 (mouse)Not determined1580884933104073951Mouse

Markers in Region
Aqp6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371599,431,933 - 99,433,420UniSTSGRCm37
Celera15101,756,895 - 101,758,446UniSTS
Cytogenetic Map15F1UniSTS
cM Map1556.9UniSTS
cM Map1556.9UniSTS
AI790337  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381599,604,889 - 99,604,972UniSTSGRCm38
MGSCv371599,435,320 - 99,435,403UniSTSGRCm37
Celera15101,760,263 - 101,760,346UniSTS
Cytogenetic Map15F1UniSTS
cM Map1556.9UniSTS
Whitehead/MRC_RH15887.18UniSTS
Aqp6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381599,601,502 - 99,602,989UniSTSGRCm38
MGSCv371599,431,933 - 99,433,420UniSTSGRCm37
Celera15101,756,895 - 101,758,446UniSTS
Cytogenetic Map15F1UniSTS
cM Map1556.9UniSTS
Aqp6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15F1UniSTS
cM Map1556.9UniSTS


Sequence


Ensembl Acc Id: ENSMUST00000023754   ⟹   ENSMUSP00000023754
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1599,499,281 - 99,503,358 (+)Ensembl
GRCm38.p6 Ensembl1599,601,400 - 99,605,477 (+)Ensembl
Ensembl Acc Id: ENSMUST00000230075   ⟹   ENSMUSP00000154934
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1599,499,281 - 99,502,362 (+)Ensembl
GRCm38.p6 Ensembl1599,601,400 - 99,604,481 (+)Ensembl
RefSeq Acc Id: NM_175087   ⟹   NP_780296
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391599,499,081 - 99,503,358 (+)NCBI
GRCm381599,601,200 - 99,605,477 (+)NCBI
MGSCv371599,431,831 - 99,435,908 (+)RGD
Celera15101,756,793 - 101,760,851 (+)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006520350   ⟹   XP_006520413
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391599,495,891 - 99,503,359 (+)NCBI
GRCm381599,598,468 - 99,605,478 (+)NCBI
Sequence:
RefSeq Acc Id: NP_780296   ⟸   NM_175087
- UniProtKB: Q8C4A0 (UniProtKB/Swiss-Prot),   Q14BV5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006520413   ⟸   XM_006520350
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000154934   ⟸   ENSMUST00000230075
Ensembl Acc Id: ENSMUSP00000023754   ⟸   ENSMUST00000023754

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8C4A0-F1-model_v2 AlphaFold Q8C4A0 1-293 view protein structure

Promoters
RGD ID:6825780
Promoter ID:MM_KWN:19695
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:NM_175087,   UC007XPV.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361599,431,886 - 99,432,386 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1341204 AgrOrtholog
Ensembl Genes ENSMUSG00000043144 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000023754 ENTREZGENE
  ENSMUST00000023754.6 UniProtKB/Swiss-Prot
  ENSMUST00000230075.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1080.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aquaporin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aquaporin_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aquaporin_transptr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11831 UniProtKB/Swiss-Prot
MGD MGI:1341204 ENTREZGENE
NCBI Gene 11831 ENTREZGENE
PANTHER PTHR19139 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR19139:SF113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aqp6 PhenoGen
PRINTS AQUAPORIN6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MINTRINSICP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81338 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A4FUR0_MOUSE UniProtKB/TrEMBL
  AQP6_MOUSE UniProtKB/Swiss-Prot
  Q14BV5 ENTREZGENE, UniProtKB/TrEMBL
  Q8C4A0 ENTREZGENE