KPNB1 (karyopherin subunit beta 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: KPNB1 (karyopherin subunit beta 1) Homo sapiens
Analyze
Symbol: KPNB1
Name: karyopherin subunit beta 1
RGD ID: 737037
HGNC Page HGNC:6400
Description: Enables enzyme binding activity; nuclear import signal receptor activity; and protein domain specific binding activity. Involved in import into nucleus; microtubule cytoskeleton organization; and mitotic sister chromatid segregation. Acts upstream of or within protein import into nucleus. Located in cytosol; endoplasmic reticulum tubular network; and nucleus. Part of NLS-dependent protein nuclear import complex. Is active in cytoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: IMB1; Impnb; importin 1; importin 90; importin beta-1 subunit; importin subunit beta-1; importin-90; IPO1; IPOB; karyopherin (importin) beta 1; karyopherin subunit beta-1; MGC2155; MGC2156; MGC2157; NTF97; nuclear factor p97; pore targeting complex 97 kDa subunit; PTAC97
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: KPNB1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381747,649,919 - 47,685,505 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1747,649,476 - 47,685,505 (+)Ensemblhg38GRCh38
GRCh371745,727,285 - 45,762,871 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361743,082,274 - 43,116,003 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341743,082,273 - 43,116,003NCBI
Celera1742,179,952 - 42,213,682 (+)NCBICelera
Cytogenetic Map17q21.32NCBI
HuRef1741,096,264 - 41,130,080 (+)NCBIHuRef
CHM1_11745,792,168 - 45,825,949 (+)NCBICHM1_1
T2T-CHM13v2.01748,511,703 - 48,547,295 (+)NCBIT2T-CHM13v2.0
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
1,1-dichloroethene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dimethoxyphenol  (EXP)
2,6-dinitrotoluene  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (ISO)
acrolein  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
alpha-pinene  (EXP)
amitrole  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (EXP)
Aroclor 1254  (ISO)
beauvericin  (EXP)
belinostat  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
Bisphenol B  (EXP)
buspirone  (ISO)
butanal  (EXP)
cadmium dichloride  (ISO)
caffeine  (EXP)
calcitriol  (EXP)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP)
cocaine  (ISO)
Dibutyl phosphate  (EXP)
dimethylarsinic acid  (ISO)
doxorubicin  (EXP)
elemental selenium  (EXP)
enniatin  (EXP)
enzyme inhibitor  (EXP)
ethanol  (ISO)
fenthion  (ISO)
finasteride  (ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (EXP)
fulvestrant  (EXP)
furfural  (EXP)
gallic acid  (EXP)
gentamycin  (ISO)
hydrogen peroxide  (EXP)
ionomycin  (EXP)
ivermectin  (EXP)
ketamine  (ISO)
L-methionine  (ISO)
lead(0)  (EXP)
levofloxacin  (ISO)
menadione  (EXP)
methimazole  (ISO)
methotrexate  (EXP)
methyl methanesulfonate  (EXP)
nitrates  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (EXP)
propiconazole  (ISO)
prostaglandin F2alpha  (ISO)
raloxifene  (EXP)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
selenium atom  (EXP)
silicon dioxide  (EXP)
sodium acetate trihydrate  (EXP)
sodium chloride  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone enanthate  (EXP)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
triadimefon  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triphenyl phosphate  (EXP)
trovafloxacin  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vitamin E  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1631159   PMID:1985200   PMID:7559393   PMID:7615630   PMID:7627554   PMID:7892216   PMID:8105392   PMID:8576188   PMID:8617226   PMID:8617227   PMID:8692944   PMID:8896452  
PMID:8909533   PMID:9045717   PMID:9102465   PMID:9135132   PMID:9144189   PMID:9214382   PMID:9261175   PMID:9275187   PMID:9275210   PMID:9323134   PMID:9366553   PMID:9398662  
PMID:9405152   PMID:9430704   PMID:9435235   PMID:9436978   PMID:9463369   PMID:9562972   PMID:9582382   PMID:9621063   PMID:9670026   PMID:9687515   PMID:9817747   PMID:9891055  
PMID:9891056   PMID:9922449   PMID:10037787   PMID:10202161   PMID:10209022   PMID:10228156   PMID:10353244   PMID:10366569   PMID:10367892   PMID:10397761   PMID:10473610   PMID:10523667  
PMID:10525473   PMID:10668806   PMID:10749866   PMID:10772949   PMID:10779340   PMID:10811646   PMID:10822175   PMID:10846168   PMID:10860744   PMID:10888652   PMID:10929717   PMID:10944119  
PMID:10951564   PMID:10965137   PMID:11024021   PMID:11032817   PMID:11035935   PMID:11257130   PMID:11266456   PMID:11278458   PMID:11283257   PMID:11297531   PMID:11310559   PMID:11311162  
PMID:11323423   PMID:11389849   PMID:11401507   PMID:11751052   PMID:11891849   PMID:11971900   PMID:11984006   PMID:12011095   PMID:12062430   PMID:12095920   PMID:12135354   PMID:12176322  
PMID:12177166   PMID:12186919   PMID:12368302   PMID:12372823   PMID:12414950   PMID:12477932   PMID:12504010   PMID:12551970   PMID:12614157   PMID:12764225   PMID:12783858   PMID:12894213  
PMID:13679510   PMID:14600264   PMID:14645851   PMID:14718574   PMID:15037768   PMID:15047060   PMID:15064744   PMID:15194443   PMID:15231748   PMID:15282309   PMID:15297880   PMID:15342649  
PMID:15383276   PMID:15388255   PMID:15489334   PMID:15494309   PMID:15507604   PMID:15572412   PMID:15795315   PMID:15851029   PMID:15864302   PMID:15870280   PMID:15889150   PMID:15929992  
PMID:15964792   PMID:16115628   PMID:16189009   PMID:16196087   PMID:16226712   PMID:16314522   PMID:16344560   PMID:16354571   PMID:16380377   PMID:16552725   PMID:16704975   PMID:16982803  
PMID:17053781   PMID:17110338   PMID:17148452   PMID:17172643   PMID:17209048   PMID:17314511   PMID:17370265   PMID:17537211   PMID:17573780   PMID:17596301   PMID:17609381   PMID:17620599  
PMID:17643375   PMID:17646395   PMID:17661632   PMID:17855385   PMID:17916694   PMID:17938174   PMID:18028944   PMID:18029348   PMID:18051367   PMID:18162579   PMID:18187047   PMID:18187419  
PMID:18238777   PMID:18258596   PMID:18398821   PMID:18445273   PMID:18655775   PMID:18854154   PMID:19056867   PMID:19117056   PMID:19149558   PMID:19156129   PMID:19275582   PMID:19322201  
PMID:19454010   PMID:19650074   PMID:19668212   PMID:19680228   PMID:19738201   PMID:19765186   PMID:19786618   PMID:19801544   PMID:19884259   PMID:19925438   PMID:19946888   PMID:19961560  
PMID:20015032   PMID:20085707   PMID:20360068   PMID:20458337   PMID:20462248   PMID:20467437   PMID:20547757   PMID:20576617   PMID:20603015   PMID:20658144   PMID:20701745   PMID:20711181  
PMID:20811636   PMID:20818336   PMID:21072240   PMID:21081503   PMID:21081666   PMID:21139048   PMID:21145461   PMID:21209321   PMID:21217699   PMID:21278340   PMID:21319273   PMID:21321119  
PMID:21326825   PMID:21401918   PMID:21466675   PMID:21625522   PMID:21630149   PMID:21832065   PMID:21858095   PMID:21873635   PMID:21890473   PMID:21900206   PMID:21901101   PMID:21906983  
PMID:21963094   PMID:21965294   PMID:21987572   PMID:22020938   PMID:22053931   PMID:22084111   PMID:22125623   PMID:22145905   PMID:22174317   PMID:22178446   PMID:22190364   PMID:22222486  
PMID:22268729   PMID:22321063   PMID:22355797   PMID:22415091   PMID:22417684   PMID:22422068   PMID:22442722   PMID:22500989   PMID:22509482   PMID:22586326   PMID:22623428   PMID:22681889  
PMID:22701565   PMID:22863883   PMID:22939629   PMID:22952844   PMID:22990118   PMID:23000965   PMID:23012356   PMID:23022380   PMID:23125841   PMID:23178491   PMID:23184937   PMID:23246001  
PMID:23277564   PMID:23414517   PMID:23438482   PMID:23444224   PMID:23472066   PMID:23533145   PMID:23538446   PMID:23557333   PMID:23602568   PMID:23729730   PMID:23783028   PMID:23798571  
PMID:23874389   PMID:23906023   PMID:23956138   PMID:24132643   PMID:24169621   PMID:24398670   PMID:24457600   PMID:24625528   PMID:24654937   PMID:24699649   PMID:24711643   PMID:24712655  
PMID:24739174   PMID:24742347   PMID:24755837   PMID:24797263   PMID:24816145   PMID:24821838   PMID:24854174   PMID:24927568   PMID:24953690   PMID:25037261   PMID:25147182   PMID:25192599  
PMID:25378659   PMID:25499977   PMID:25562883   PMID:25643631   PMID:25696812   PMID:25737280   PMID:25748139   PMID:25756610   PMID:25794490   PMID:25798074   PMID:25852190   PMID:25890085  
PMID:25921289   PMID:25940091   PMID:25959826   PMID:25960398   PMID:25963833   PMID:26107903   PMID:26112410   PMID:26186194   PMID:26195665   PMID:26209609   PMID:26216267   PMID:26217791  
PMID:26242264   PMID:26319354   PMID:26344197   PMID:26414402   PMID:26438829   PMID:26468281   PMID:26472760   PMID:26491019   PMID:26496610   PMID:26498772   PMID:26511642   PMID:26514267  
PMID:26598607   PMID:26618866   PMID:26638075   PMID:26641092   PMID:26687479   PMID:26693507   PMID:26725010   PMID:26760575   PMID:26777405   PMID:26831064   PMID:26893479   PMID:26972000  
PMID:26979993   PMID:27025967   PMID:27173435   PMID:27528606   PMID:27568288   PMID:27609421   PMID:27634302   PMID:27684187   PMID:27808165   PMID:27880917   PMID:27939291   PMID:28027390  
PMID:28179136   PMID:28186131   PMID:28192407   PMID:28302793   PMID:28330616   PMID:28427184   PMID:28443643   PMID:28514442   PMID:28515276   PMID:28524877   PMID:28581483   PMID:28675297  
PMID:28685749   PMID:28698143   PMID:28712289   PMID:28718761   PMID:28835592   PMID:28864541   PMID:28877994   PMID:29017749   PMID:29128334   PMID:29180619   PMID:29229926   PMID:29251332  
PMID:29331416   PMID:29346117   PMID:29378950   PMID:29416926   PMID:29467282   PMID:29507755   PMID:29509190   PMID:29520102   PMID:29568061   PMID:29593330   PMID:29622086   PMID:29669786  
PMID:29734393   PMID:29746765   PMID:29777862   PMID:29791485   PMID:29844126   PMID:29845934   PMID:29934401   PMID:29957337   PMID:30097533   PMID:30153455   PMID:30258100   PMID:30344098  
PMID:30442662   PMID:30445944   PMID:30455355   PMID:30462309   PMID:30463901   PMID:30554943   PMID:30575818   PMID:30711629   PMID:30737378   PMID:30742095   PMID:30773093   PMID:30804502  
PMID:30809309   PMID:30833792   PMID:30884312   PMID:30887716   PMID:30890647   PMID:30948266   PMID:31073040   PMID:31091453   PMID:31180492   PMID:31239290   PMID:31267705   PMID:31319097  
PMID:31324722   PMID:31409639   PMID:31413325   PMID:31434716   PMID:31586073   PMID:31594818   PMID:31629952   PMID:31642884   PMID:31653923   PMID:31685992   PMID:31732153   PMID:31839598  
PMID:31980649   PMID:31995728   PMID:32129710   PMID:32132601   PMID:32160526   PMID:32235678   PMID:32347575   PMID:32450252   PMID:32494626   PMID:32509391   PMID:32513696   PMID:32529326  
PMID:32665550   PMID:32687490   PMID:32738194   PMID:32807901   PMID:32850835   PMID:32905556   PMID:32963011   PMID:32994395   PMID:33239621   PMID:33301849   PMID:33306668   PMID:33439253  
PMID:33503405   PMID:33536335   PMID:33545068   PMID:33545070   PMID:33567341   PMID:33618749   PMID:33644029   PMID:33742100   PMID:33766124   PMID:33801927   PMID:33916271   PMID:33961781  
PMID:34079125   PMID:34189442   PMID:34244482   PMID:34349018   PMID:34373451   PMID:34428256   PMID:34591877   PMID:34662580   PMID:34901782   PMID:34917906   PMID:34921745   PMID:35021089  
PMID:35044719   PMID:35063084   PMID:35122331   PMID:35227662   PMID:35235311   PMID:35241646   PMID:35256949   PMID:35271311   PMID:35338135   PMID:35439318   PMID:35446349   PMID:35509820  
PMID:35546148   PMID:35562734   PMID:35563538   PMID:35575683   PMID:35676246   PMID:35687106   PMID:35776542   PMID:35800763   PMID:35831314   PMID:35850772   PMID:35864095   PMID:35896951  
PMID:35902727   PMID:35914814   PMID:35944360   PMID:35945192   PMID:36042349   PMID:36055981   PMID:36114006   PMID:36168627   PMID:36180527   PMID:36180891   PMID:36215168   PMID:36282215  
PMID:36339263   PMID:36373674   PMID:36376293   PMID:36418423   PMID:36424410   PMID:36490346   PMID:36517590   PMID:36526897   PMID:36574265   PMID:36584595   PMID:36658650   PMID:36690276  
PMID:36762613   PMID:36779763   PMID:36912080   PMID:36929488   PMID:36964131   PMID:37052853   PMID:37059091   PMID:37071682   PMID:37166548   PMID:37167062   PMID:37223481   PMID:37267103  
PMID:37314180   PMID:37314216   PMID:37317656   PMID:37429858   PMID:37433992   PMID:37448957   PMID:37473981   PMID:37516964   PMID:37689310   PMID:37723588   PMID:37774976   PMID:37820061  
PMID:37827155   PMID:37929963   PMID:38043095   PMID:38113892   PMID:38132118   PMID:38254206   PMID:38280479   PMID:38507240   PMID:38512451   PMID:38514841   PMID:38697112   PMID:39231216  
PMID:39501047  


Genomics

Comparative Map Data
KPNB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381747,649,919 - 47,685,505 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1747,649,476 - 47,685,505 (+)Ensemblhg38GRCh38
GRCh371745,727,285 - 45,762,871 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361743,082,274 - 43,116,003 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341743,082,273 - 43,116,003NCBI
Celera1742,179,952 - 42,213,682 (+)NCBICelera
Cytogenetic Map17q21.32NCBI
HuRef1741,096,264 - 41,130,080 (+)NCBIHuRef
CHM1_11745,792,168 - 45,825,949 (+)NCBICHM1_1
T2T-CHM13v2.01748,511,703 - 48,547,295 (+)NCBIT2T-CHM13v2.0
Kpnb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391197,050,536 - 97,078,718 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1197,050,540 - 97,078,707 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381197,159,710 - 97,187,892 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1197,159,714 - 97,187,881 (-)Ensemblmm10GRCm38
MGSCv371197,021,024 - 97,049,206 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361196,975,800 - 97,003,982 (-)NCBIMGSCv36mm8
Celera11106,812,630 - 106,840,820 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1160.95NCBI
Kpnb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81082,642,082 - 82,670,856 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1082,642,082 - 82,670,856 (-)EnsemblGRCr8
mRatBN7.21082,145,662 - 82,174,437 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1082,145,420 - 82,174,605 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1087,094,110 - 87,122,899 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01086,592,172 - 86,620,969 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01081,984,776 - 82,013,559 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01085,096,517 - 85,124,641 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1085,093,841 - 85,124,644 (-)Ensemblrn6Rnor6.0
Rnor_5.01084,886,484 - 84,914,805 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41085,882,382 - 85,910,805 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1080,906,145 - 80,931,812 (-)NCBICelera
RGSC_v3.11085,896,751 - 85,925,175 (-)NCBI
Cytogenetic Map10q31NCBI
Kpnb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545113,365,476 - 13,398,491 (-)Ensembl
ChiLan1.0NW_00495545113,365,881 - 13,398,491 (-)NCBIChiLan1.0ChiLan1.0
KPNB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21917,417,441 - 17,453,002 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11719,382,919 - 19,418,880 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0179,852,424 - 9,887,111 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11710,035,738 - 10,068,401 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1710,035,732 - 10,068,913 (-)EnsemblpanPan2panpan1.1
KPNB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1924,004,191 - 24,031,370 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl924,003,968 - 24,028,531 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha923,470,348 - 23,497,535 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0924,796,218 - 24,823,411 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl924,795,998 - 24,821,055 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1923,566,722 - 23,593,892 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0923,827,962 - 23,855,184 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0923,954,771 - 23,981,965 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kpnb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560223,439,655 - 23,471,619 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649013,603,498 - 13,635,682 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649013,603,520 - 13,635,567 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KPNB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1223,916,164 - 23,944,588 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11223,915,783 - 23,945,407 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21223,785,821 - 23,813,399 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KPNB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11668,047,473 - 68,083,290 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1668,047,491 - 68,084,778 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607739,091,438 - 39,128,535 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kpnb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247954,371,749 - 4,403,217 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247954,372,014 - 4,403,061 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in KPNB1
22 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q21.33-24.2(chr17:36449220-68170214)x3 copy number gain See cases [RCV000050957] Chr17:36449220..68170214 [GRCh38]
Chr17:48563237..65936105 [GRCh37]
Chr17:45918236..63677950 [NCBI36]
Chr17:17q21.33-24.2		 pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3		 pathogenic
GRCh38/hg38 17q21.31-21.33(chr17:44955325-49381173)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052480]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052480]|See cases [RCV000052480] Chr17:44955325..49381173 [GRCh38]
Chr17:43032693..47458535 [GRCh37]
Chr17:40388219..44813534 [NCBI36]
Chr17:17q21.31-21.33		 pathogenic
NM_002265.5(KPNB1):c.1959C>T (p.Phe653=) single nucleotide variant Malignant melanoma [RCV000063235] Chr17:47676455 [GRCh38]
Chr17:45753821 [GRCh37]
Chr17:43108820 [NCBI36]
Chr17:17q21.32		 not provided
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1		 pathogenic
chr17:45008570..45994044 complex variant complex Breast ductal adenocarcinoma [RCV000207217] Chr17:45008570..45994044 [GRCh37]
Chr17:17q21.32		 uncertain significance
GRCh37/hg19 17q21.31-25.3(chr17:42580684-81085615)x3 copy number gain See cases [RCV000447823] Chr17:42580684..81085615 [GRCh37]
Chr17:17q21.31-25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
NM_002265.6(KPNB1):c.1983T>C (p.Tyr661=) single nucleotide variant not provided [RCV000892680] Chr17:47676479 [GRCh38]
Chr17:45753845 [GRCh37]
Chr17:17q21.32		 benign
GRCh37/hg19 17q21.32(chr17:44949883-46507482) copy number gain PNPO-related disorder [RCV003236737] Chr17:44949883..46507482 [GRCh37]
Chr17:17q21.32		 likely pathogenic
NM_002265.6(KPNB1):c.746A>G (p.Tyr249Cys) single nucleotide variant not specified [RCV004099180] Chr17:47663138 [GRCh38]
Chr17:45740504 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_002265.6(KPNB1):c.530T>C (p.Ile177Thr) single nucleotide variant not specified [RCV004169359] Chr17:47658554 [GRCh38]
Chr17:45735920 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_002265.6(KPNB1):c.1490A>C (p.Tyr497Ser) single nucleotide variant not specified [RCV004268909] Chr17:47670775 [GRCh38]
Chr17:45748141 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_002265.6(KPNB1):c.1963G>A (p.Gly655Ser) single nucleotide variant not specified [RCV004329454] Chr17:47676459 [GRCh38]
Chr17:45753825 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_002265.6(KPNB1):c.191C>T (p.Ser64Phe) single nucleotide variant not specified [RCV004412056] Chr17:47652785 [GRCh38]
Chr17:45730151 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_002265.6(KPNB1):c.428C>T (p.Thr143Ile) single nucleotide variant not specified [RCV004412057] Chr17:47657005 [GRCh38]
Chr17:45734371 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_002265.6(KPNB1):c.809G>A (p.Ser270Asn) single nucleotide variant not specified [RCV004412058] Chr17:47664181 [GRCh38]
Chr17:45741547 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_002265.6(KPNB1):c.2555G>A (p.Arg852Lys) single nucleotide variant not specified [RCV004644357] Chr17:47680594 [GRCh38]
Chr17:45757960 [GRCh37]
Chr17:17q21.32		 uncertain significance
Single allele deletion Breast-ovarian cancer, familial, susceptibility to, 1 [RCV004759420] Chr17:41231503..41277589 [GRCh37]
Chr17:17q21.31-22		 pathogenic
GRCh37/hg19 17q12-22(chr17:41196270-41277589) copy number loss Breast-ovarian cancer, familial, susceptibility to, 1 [RCV004759419] Chr17:41196270..41277589 [GRCh37]
Chr17:17q12-22		 pathogenic
NM_002265.6(KPNB1):c.782T>C (p.Phe261Ser) single nucleotide variant not specified [RCV004935873] Chr17:47663174 [GRCh38]
Chr17:45740540 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_002265.6(KPNB1):c.1550C>T (p.Pro517Leu) single nucleotide variant not specified [RCV005360857] Chr17:47673020 [GRCh38]
Chr17:45750386 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_002265.6(KPNB1):c.748C>G (p.Gln250Glu) single nucleotide variant not specified [RCV005360856] Chr17:47663140 [GRCh38]
Chr17:45740506 [GRCh37]
Chr17:17q21.32		 uncertain significance
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:3442
Count of miRNA genes:1166
Interacting mature miRNAs:1449
Transcripts:ENST00000290158, ENST00000535458, ENST00000537679, ENST00000540627, ENST00000577875, ENST00000577918, ENST00000578718, ENST00000579901, ENST00000580019, ENST00000580158, ENST00000580573, ENST00000582097, ENST00000582126, ENST00000583013, ENST00000583648
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
597105302GWAS1201376_Hsex hormone-binding globulin measurement QTL GWAS1201376 (human)3e-40sex hormone-binding globulin measurement174765990947659910Human
597274525GWAS1370599_Hlow density lipoprotein cholesterol measurement QTL GWAS1370599 (human)1e-10blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)174765834047658341Human
597142674GWAS1238748_Hlow density lipoprotein cholesterol measurement QTL GWAS1238748 (human)0.0000007blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)174765990947659910Human
597305119GWAS1401193_HBMI-adjusted hip circumference QTL GWAS1401193 (human)4e-14BMI-adjusted hip circumferencehip circumference (CMO:0000014)174767118647671187Human
597028999GWAS1125073_Hhigh density lipoprotein cholesterol measurement QTL GWAS1125073 (human)0.0000004blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)174765523947655240Human
597169676GWAS1265750_Hbody weight QTL GWAS1265750 (human)1e-11body mass (VT:0001259)body weight (CMO:0000012)174765834047658341Human
597025922GWAS1121996_Hhigh density lipoprotein cholesterol measurement QTL GWAS1121996 (human)2e-08low density lipoprotein cholesterol measurement174765523947655240Human
407095003GWAS743979_Hlow density lipoprotein cholesterol measurement, alcohol drinking QTL GWAS743979 (human)5e-24drinking behavior trait (VT:0001422)blood low density lipoprotein cholesterol level (CMO:0000053)174765523947655240Human
597025423GWAS1121497_Htriglyceride measurement QTL GWAS1121497 (human)0.000006triglyceride amount (VT:0000187)blood triglyceride level (CMO:0000118)174765523947655240Human
597259394GWAS1355468_Hsex hormone-binding globulin measurement QTL GWAS1355468 (human)4e-59sex hormone-binding globulin measurement174765990947659910Human
597275653GWAS1371727_Hlow density lipoprotein cholesterol measurement QTL GWAS1371727 (human)8e-88blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)174765523947655240Human
407073635GWAS722611_Halcohol drinking, high density lipoprotein cholesterol measurement QTL GWAS722611 (human)7e-08alcohol consumption measurement, high density lipoprotein cholesterol measurement174765523947655240Human
597108660GWAS1204734_HHMG CoA reductase inhibitor use measurement QTL GWAS1204734 (human)4e-09HMG CoA reductase inhibitor use measurement174767494447674945Human
597184444GWAS1280518_Hfree cholesterol in very small VLDL measurement QTL GWAS1280518 (human)6e-10blood VLDL cholesterol amount (VT:0005144)174767537247675373Human
597281589GWAS1377663_Hsex hormone-binding globulin measurement QTL GWAS1377663 (human)3e-11sex hormone-binding globulin measurement174767537247675373Human
597322039GWAS1418113_Hhigh density lipoprotein cholesterol measurement QTL GWAS1418113 (human)5e-15blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)174765990947659910Human
597142714GWAS1238788_Htotal cholesterol measurement QTL GWAS1238788 (human)4e-09blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)174765990947659910Human
407084659GWAS733635_Htriglyceride measurement QTL GWAS733635 (human)9e-08triglyceride amount (VT:0000187)blood triglyceride level (CMO:0000118)174765523947655240Human
597105700GWAS1201774_Hsex hormone-binding globulin measurement QTL GWAS1201774 (human)7e-62sex hormone-binding globulin measurement174765990947659910Human
597282351GWAS1378425_Hesterified cholesterol measurement, intermediate density lipoprotein measurement QTL GWAS1378425 (human)8e-13blood IDL cholesterol amount (VT:0010503)blood intermediate density lipoprotein cholesterol level (CMO:0001562)174765834047658341Human
597157807GWAS1253881_Hsex hormone-binding globulin measurement QTL GWAS1253881 (human)2e-21sex hormone-binding globulin measurement174765990947659910Human
407073914GWAS722890_Htriglyceride measurement, alcohol drinking QTL GWAS722890 (human)6e-09drinking behavior trait (VT:0001422)blood triglyceride level (CMO:0000118)174765523947655240Human
597027118GWAS1123192_Hlow density lipoprotein cholesterol measurement QTL GWAS1123192 (human)2e-11blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)174765523947655240Human
597192152GWAS1288226_Hfree androgen index QTL GWAS1288226 (human)4e-35free androgen index174767323047673231Human
597025873GWAS1121947_Htriglyceride measurement QTL GWAS1121947 (human)0.0000001triglyceride amount (VT:0000187)blood triglyceride level (CMO:0000118)174765523947655240Human
597284316GWAS1380390_Htotal cholesterol in IDL QTL GWAS1380390 (human)2e-13total cholesterol in IDL174765834047658341Human
597322710GWAS1418784_Hnon-high density lipoprotein cholesterol measurement QTL GWAS1418784 (human)5e-08blood non-HDL cholesterol amount (VT:0010474)blood non-high density lipoprotein cholesterol level (CMO:0003967)174765353347653534Human
597581266GWAS1638126_Htotal cholesterol measurement QTL GWAS1638126 (human)7e-09blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)174765990947659910Human
597156442GWAS1252516_Hsex hormone-binding globulin measurement QTL GWAS1252516 (human)7e-58sex hormone-binding globulin measurement174765990947659910Human
597027291GWAS1123365_Hhigh density lipoprotein cholesterol measurement QTL GWAS1123365 (human)0.000002triglyceride amount (VT:0000187)blood triglyceride level (CMO:0000118)174765523947655240Human
597051609GWAS1147683_Hlow density lipoprotein cholesterol measurement, physical activity QTL GWAS1147683 (human)8e-20blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)174765523947655240Human
597103687GWAS1199761_Hresponse to simvastatin, myopathy QTL GWAS1199761 (human)0.000006response to simvastatin, myopathy174767130247671303Human
597280206GWAS1376280_Hsex hormone-binding globulin measurement QTL GWAS1376280 (human)6e-16sex hormone-binding globulin measurement174767537247675373Human
597068494GWAS1164568_Htotal cholesterol measurement QTL GWAS1164568 (human)2e-22blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)174765834047658341Human
597068493GWAS1164567_Htotal cholesterol measurement QTL GWAS1164567 (human)1e-19blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)174765834047658341Human
597322177GWAS1418251_Hhigh density lipoprotein cholesterol measurement QTL GWAS1418251 (human)2e-23blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)174765990947659910Human
597156299GWAS1252373_Hsex hormone-binding globulin measurement QTL GWAS1252373 (human)2e-25sex hormone-binding globulin measurement174765990947659910Human
597280710GWAS1376784_Hsex hormone-binding globulin measurement QTL GWAS1376784 (human)9e-18sex hormone-binding globulin measurement174765990947659910Human
597282169GWAS1378243_Hcholesterol:total lipids ratio, low density lipoprotein cholesterol measurement QTL GWAS1378243 (human)1e-10blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)174766365047663651Human
597156467GWAS1252541_Hfree cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement QTL GWAS1252541 (human)2e-11blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)174767323047673231Human
597023865GWAS1119939_Hlow density lipoprotein cholesterol measurement QTL GWAS1119939 (human)8e-23blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)174765834047658341Human
597023866GWAS1119940_Hlow density lipoprotein cholesterol measurement QTL GWAS1119940 (human)2e-25blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)174765834047658341Human
597311978GWAS1408052_HHMG CoA reductase inhibitor use measurement QTL GWAS1408052 (human)2e-12HMG CoA reductase inhibitor use measurement174767494447674945Human
597258856GWAS1354930_Htotal cholesterol measurement QTL GWAS1354930 (human)3e-08blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)174765834047658341Human
597192937GWAS1289011_Htestosterone measurement QTL GWAS1289011 (human)4e-26blood testosterone amount (VT:0005180)serum testosterone level (CMO:0000568)174767323047673231Human
407071159GWAS720135_Htriglyceride measurement, alcohol drinking QTL GWAS720135 (human)0.0000005drinking behavior trait (VT:0001422)blood triglyceride level (CMO:0000118)174765523947655240Human
597096546GWAS1192620_Htotal cholesterol measurement QTL GWAS1192620 (human)3e-14blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)174765990947659910Human
597282030GWAS1378104_Hfree cholesterol:total lipids ratio, intermediate density lipoprotein measurement QTL GWAS1378104 (human)7e-10blood IDL cholesterol amount (VT:0010503)blood intermediate density lipoprotein cholesterol level (CMO:0001562)174766365047663651Human
407072827GWAS721803_Hlow density lipoprotein cholesterol measurement, alcohol drinking QTL GWAS721803 (human)3e-17drinking behavior trait (VT:0001422)blood low density lipoprotein cholesterol level (CMO:0000053)174765523947655240Human
597205728GWAS1301802_Hglycine measurement QTL GWAS1301802 (human)4e-11blood glycine amount (VT:0010965)blood amino acid measurement (CMO:0003730)174765834047658341Human
597286497GWAS1382571_Hphospholipids in small LDL measurement QTL GWAS1382571 (human)2e-09phospholipids in small LDL measurement 174765834047658341Human
597159918GWAS1255992_Hglycine measurement QTL GWAS1255992 (human)2e-24blood glycine amount (VT:0010965)blood amino acid measurement (CMO:0003730)174766902047669022Human
597188193GWAS1284267_Hphospholipids:total lipids ratio QTL GWAS1284267 (human)1e-10phospholipids:total lipids ratio174767323047673231Human
597285987GWAS1382061_Hesterified cholesterol measurement QTL GWAS1382061 (human)3e-11blood chylomicron cholesterol amount (VT:0010697)174765834047658341Human
597025770GWAS1121844_Halcohol drinking, high density lipoprotein cholesterol measurement QTL GWAS1121844 (human)5e-08blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)174765523947655240Human

Markers in Region
STS-H47054  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377149,019,054 - 149,019,182UniSTSGRCh37
GRCh371745,757,434 - 45,757,935UniSTSGRCh37
Build 367148,649,987 - 148,650,115RGDNCBI36
Celera7143,688,253 - 143,688,381RGD
Celera1742,210,114 - 42,210,615UniSTS
Cytogenetic Map17q21.32UniSTS
HuRef7143,095,923 - 143,096,051UniSTS
HuRef1741,126,513 - 41,127,014UniSTS
CRA_TCAGchr7v27148,357,054 - 148,357,182UniSTS
GeneMap99-GB4 RH Map7675.32UniSTS
SHGC-2553  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371745,760,791 - 45,760,950UniSTSGRCh37
GRCh371453,466,300 - 53,466,463UniSTSGRCh37
Build 361452,536,050 - 52,536,213RGDNCBI36
Celera1433,516,040 - 33,516,203RGD
Celera1742,213,469 - 42,213,628UniSTS
Cytogenetic Map17q21.32UniSTS
HuRef1741,129,867 - 41,130,026UniSTS
HuRef1433,629,401 - 33,629,564UniSTS
RH119587  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371745,730,052 - 45,730,359UniSTSGRCh37
Build 361743,085,051 - 43,085,358RGDNCBI36
Celera1742,182,732 - 42,183,039RGD
Cytogenetic Map17q21.32UniSTS
HuRef1741,099,137 - 41,099,444UniSTS
KPNB1_2429  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377149,018,140 - 149,018,948UniSTSGRCh37
GRCh371745,759,775 - 45,760,527UniSTSGRCh37
Build 367148,649,073 - 148,649,881RGDNCBI36
Celera7143,687,342 - 143,688,147RGD
Celera1742,212,453 - 42,213,205UniSTS
HuRef7143,095,012 - 143,095,817UniSTS
HuRef1741,128,852 - 41,129,603UniSTS
CRA_TCAGchr7v27148,356,143 - 148,356,948UniSTS
D11S4360  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17q21.32UniSTS
RH68781  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17q21.32UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2251 4973 1726 2351 6 623 1951 465 2269 7303 6469 53 3734 1 852 1744 1617 175 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001276453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC015674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC025682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC244084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI076614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK299145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK316421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC024045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC036703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE046507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ009884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT009797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS531808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB083013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF456283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF570270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L38951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L39793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L39924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000290158   ⟹   ENSP00000290158
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1747,649,919 - 47,685,505 (+)Ensembl
Ensembl Acc Id: ENST00000535458   ⟹   ENSP00000438253
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1747,649,476 - 47,682,633 (+)Ensembl
Ensembl Acc Id: ENST00000540627   ⟹   ENSP00000438964
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1747,651,196 - 47,682,680 (+)Ensembl
Ensembl Acc Id: ENST00000577875   ⟹   ENSP00000464200
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1747,650,358 - 47,658,641 (+)Ensembl
Ensembl Acc Id: ENST00000577918
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1747,650,152 - 47,662,238 (+)Ensembl
Ensembl Acc Id: ENST00000578718
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1747,670,377 - 47,674,755 (+)Ensembl
Ensembl Acc Id: ENST00000579901
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1747,670,324 - 47,676,486 (+)Ensembl
Ensembl Acc Id: ENST00000580019
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1747,673,089 - 47,673,839 (+)Ensembl
Ensembl Acc Id: ENST00000580158
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1747,676,077 - 47,683,085 (+)Ensembl
Ensembl Acc Id: ENST00000580573
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1747,675,714 - 47,683,077 (+)Ensembl
Ensembl Acc Id: ENST00000582097   ⟹   ENSP00000463066
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1747,656,925 - 47,682,680 (+)Ensembl
Ensembl Acc Id: ENST00000582126   ⟹   ENSP00000462243
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1747,680,603 - 47,684,511 (+)Ensembl
Ensembl Acc Id: ENST00000583013   ⟹   ENSP00000463190
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1747,668,365 - 47,673,561 (+)Ensembl
Ensembl Acc Id: ENST00000583648   ⟹   ENSP00000464042
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1747,649,495 - 47,685,505 (+)Ensembl
Ensembl Acc Id: ENST00000677036
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1747,660,882 - 47,668,801 (+)Ensembl
Ensembl Acc Id: ENST00000677341
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1747,669,573 - 47,683,089 (+)Ensembl
RefSeq Acc Id: NM_001276453   ⟹   NP_001263382
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381747,651,065 - 47,685,505 (+)NCBI
HuRef1741,096,264 - 41,130,080 (+)NCBI
CHM1_11745,793,526 - 45,825,949 (+)NCBI
T2T-CHM13v2.01748,512,849 - 48,547,295 (+)NCBI
Sequence:
RefSeq Acc Id: NM_002265   ⟹   NP_002256
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381747,649,919 - 47,685,505 (+)NCBI
GRCh371745,726,861 - 45,762,037 (+)NCBI
Build 361743,082,274 - 43,116,003 (+)NCBI Archive
HuRef1741,096,264 - 41,130,080 (+)NCBI
CHM1_11745,792,168 - 45,825,949 (+)NCBI
T2T-CHM13v2.01748,511,703 - 48,547,295 (+)NCBI
Sequence:
RefSeq Acc Id: NP_002256   ⟸   NM_002265
- Peptide Label: isoform 1
- UniProtKB: Q53XN2 (UniProtKB/Swiss-Prot),   Q14637 (UniProtKB/Swiss-Prot),   D3DTT3 (UniProtKB/Swiss-Prot),   B7ZAV6 (UniProtKB/Swiss-Prot),   Q96J27 (UniProtKB/Swiss-Prot),   Q14974 (UniProtKB/Swiss-Prot),   B2RBR9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001263382   ⟸   NM_001276453
- Peptide Label: isoform 2
- UniProtKB: B7Z752 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000463066   ⟸   ENST00000582097
Ensembl Acc Id: ENSP00000462243   ⟸   ENST00000582126
Ensembl Acc Id: ENSP00000463190   ⟸   ENST00000583013
Ensembl Acc Id: ENSP00000464042   ⟸   ENST00000583648
Ensembl Acc Id: ENSP00000438253   ⟸   ENST00000535458
Ensembl Acc Id: ENSP00000464200   ⟸   ENST00000577875
Ensembl Acc Id: ENSP00000290158   ⟸   ENST00000290158
Ensembl Acc Id: ENSP00000438964   ⟸   ENST00000540627
Protein Domains
Importin N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q14974-F1-model_v2 AlphaFold Q14974 1-876 view protein structure

Promoters
RGD ID:6794263
Promoter ID:HG_KWN:26454
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_002265
Position:
Human AssemblyChrPosition (strand)Source
Build 361743,081,471 - 43,082,757 (+)MPROMDB
RGD ID:6815185
Promoter ID:HG_MRA:6844
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   K562,   Lymphoblastoid
Transcripts:AK301463
Position:
Human AssemblyChrPosition (strand)Source
Build 361743,082,759 - 43,083,259 (+)MPROMDB
RGD ID:6811231
Promoter ID:HG_ACW:35053
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:KPNB1.GAPR07,   KPNB1.HAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 361743,102,701 - 43,103,201 (+)MPROMDB
RGD ID:7235415
Promoter ID:EPDNEW_H23453
Type:initiation region
Name:KPNB1_2
Description:karyopherin subunit beta 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H23454  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381747,649,399 - 47,649,459EPDNEW
RGD ID:7235417
Promoter ID:EPDNEW_H23454
Type:initiation region
Name:KPNB1_1
Description:karyopherin subunit beta 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H23453  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381747,649,941 - 47,650,001EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6400 AgrOrtholog
COSMIC KPNB1 COSMIC
Ensembl Genes ENSG00000108424 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000290158 ENTREZGENE
  ENST00000290158.9 UniProtKB/Swiss-Prot
  ENST00000535458.6 UniProtKB/Swiss-Prot
  ENST00000540627 ENTREZGENE
  ENST00000540627.5 UniProtKB/Swiss-Prot
  ENST00000583648.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.10.10 UniProtKB/Swiss-Prot
GTEx ENSG00000108424 GTEx
HGNC ID HGNC:6400 ENTREZGENE
Human Proteome Map KPNB1 Human Proteome Map
InterPro ARM-like UniProtKB/Swiss-Prot
  ARM-type_fold UniProtKB/Swiss-Prot
  Armadillo UniProtKB/Swiss-Prot
  HEAT_type_2 UniProtKB/Swiss-Prot
  Importin-beta_N UniProtKB/Swiss-Prot
  Importin_beta UniProtKB/Swiss-Prot
KEGG Report hsa:3837 UniProtKB/Swiss-Prot
NCBI Gene 3837 ENTREZGENE
OMIM 602738 OMIM
PANTHER PTHR10527 UniProtKB/Swiss-Prot
Pfam HEAT_EZ UniProtKB/Swiss-Prot
  IBN_N UniProtKB/Swiss-Prot
PharmGKB PA30191 PharmGKB
PROSITE HEAT_REPEAT UniProtKB/Swiss-Prot
  IMPORTIN_B_NT UniProtKB/Swiss-Prot
SMART ARM UniProtKB/Swiss-Prot
  IBN_N UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot
UniProt B2RBR9 ENTREZGENE, UniProtKB/TrEMBL
  B7Z752 ENTREZGENE, UniProtKB/TrEMBL
  B7ZAV6 ENTREZGENE
  D3DTT3 ENTREZGENE
  IMB1_HUMAN UniProtKB/Swiss-Prot
  J3KS06_HUMAN UniProtKB/TrEMBL
  J3KTM9_HUMAN UniProtKB/TrEMBL
  J3QKQ5_HUMAN UniProtKB/TrEMBL
  J3QR48_HUMAN UniProtKB/TrEMBL
  J3QRG4_HUMAN UniProtKB/TrEMBL
  Q14637 ENTREZGENE
  Q14974 ENTREZGENE
  Q53XN2 ENTREZGENE
  Q96J27 ENTREZGENE
UniProt Secondary B7ZAV6 UniProtKB/Swiss-Prot
  D3DTT3 UniProtKB/Swiss-Prot
  Q14637 UniProtKB/Swiss-Prot
  Q53XN2 UniProtKB/Swiss-Prot
  Q96J27 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-10 KPNB1  karyopherin subunit beta 1  KPNB1  karyopherin (importin) beta 1  Symbol and/or name change 5135510 APPROVED