Lhx3 (LIM homeobox protein 3) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Lhx3 (LIM homeobox protein 3) Mus musculus
Analyze
Symbol: Lhx3
Name: LIM homeobox protein 3
RGD ID: 736998
MGI Page MGI
Description: Enables transcription cis-regulatory region binding activity and transcription coactivator binding activity. Involved in positive regulation of DNA-templated transcription. Acts upstream of or within several processes, including nervous system development; placenta development; and positive regulation of transcription by RNA polymerase II. Located in chromatin. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Used to study hypopituitarism. Human ortholog(s) of this gene implicated in combined pituitary hormone deficiency. Orthologous to human LHX3 (LIM homeobox 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: homeobox protein LIM-3; homeobox protein P-LIM; Li; LIM homeo box protein 3; LIM/homeobox protein Lhx3; Lim3; mLim; mLim-3; mLIM3; P-; P-LIM
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39226,090,224 - 26,098,261 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl226,090,224 - 26,098,301 (-)EnsemblGRCm39 Ensembl
GRCm38226,200,212 - 26,208,249 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl226,200,212 - 26,208,289 (-)EnsemblGRCm38mm10GRCm38
MGSCv37226,055,732 - 26,062,076 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36226,022,956 - 26,030,258 (-)NCBIMGSCv36mm8
Celera225,922,727 - 25,929,069 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map218.44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal abducens nerve morphology  (IAGP)
abnormal corticotroph morphology  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal fertility/fecundity  (IAGP)
abnormal hypoglossal nerve morphology  (IAGP)
abnormal internal male genitalia morphology  (IAGP)
abnormal motor neuron morphology  (IAGP)
abnormal pituitary gland development  (IAGP)
abnormal pituitary gland morphology  (IAGP)
abnormal pituitary hormone level  (IAGP)
abnormal Rathke's pouch apoptosis  (IAGP)
abnormal Rathke's pouch development  (IAGP)
abnormal sex gland secretion  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal spinal nerve morphology  (IAGP)
abnormal thyroid follicle morphology  (IAGP)
abnormal uterus development  (IAGP)
abnormal uterus morphology  (IAGP)
abnormal ventral spinal root morphology  (IAGP)
absent adenohypophysis  (IAGP)
absent lactotrophs  (IAGP)
absent pituitary intermediate lobe  (IAGP)
absent somatotrophs  (IAGP)
absent thyrotrophs  (IAGP)
adenohypophysis hypoplasia  (IAGP)
adrenal cortical hyperplasia  (IAGP)
azoospermia  (IAGP)
cachexia  (IAGP)
decreased activity of thyroid gland  (IAGP)
decreased adrenocorticotropin level  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased circulating insulin-like growth factor I level  (IAGP)
decreased circulating prolactin level  (IAGP)
decreased circulating thyroxine level  (IAGP)
decreased follicle stimulating hormone level  (IAGP)
decreased gonadotroph cell number  (IAGP)
decreased growth hormone level  (IAGP)
decreased lactotroph cell number  (IAGP)
decreased luteinizing hormone level  (IAGP)
decreased motor neuron number  (IAGP)
decreased prolactin level  (IAGP)
decreased survivor rate  (IAGP)
decreased thyroid-stimulating hormone level  (IAGP)
decreased uterus weight  (IAGP)
delayed sexual maturation  (IAGP)
female infertility  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
reduced male fertility  (IAGP)
small pituitary intermediate lobe  (IAGP)
small prostate gland  (IAGP)
small seminal vesicle  (IAGP)
small testis  (IAGP)
small uterus  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. Lu QR, etal., Cell 2002 Apr 5;109(1):75-86.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. An isoform-specific inhibitory domain regulates the LHX3 LIM homeodomain factor holoprotein and the production of a functional alternate translation form. Sloop KW, etal., J Biol Chem 2001 Sep 28;276(39):36311-9.
Additional References at PubMed
PMID:7626792   PMID:7665181   PMID:7708713   PMID:7811383   PMID:8565076   PMID:8597642   PMID:8638120   PMID:8755540   PMID:8756299   PMID:8799160   PMID:8812059   PMID:8817562  
PMID:8889548   PMID:8934515   PMID:9136764   PMID:9192866   PMID:9207461   PMID:9230312   PMID:9388186   PMID:9463347   PMID:9514159   PMID:9736723   PMID:9806931   PMID:9828088  
PMID:9865699   PMID:9988216   PMID:10049363   PMID:10217145   PMID:10349636   PMID:10406041   PMID:10431247   PMID:10477289   PMID:10482234   PMID:10482235   PMID:10498698   PMID:10499586  
PMID:10593900   PMID:10598593   PMID:10677261   PMID:10717474   PMID:10835633   PMID:10934027   PMID:11042159   PMID:11071765   PMID:11076861   PMID:11152636   PMID:11217851   PMID:11420609  
PMID:11449277   PMID:11502253   PMID:11566099   PMID:11567614   PMID:11707329   PMID:11731482   PMID:11807026   PMID:11882901   PMID:12086327   PMID:12150931   PMID:12183375   PMID:12466851  
PMID:12477932   PMID:12571110   PMID:12684778   PMID:12797958   PMID:14645517   PMID:14681479   PMID:14766174   PMID:15037319   PMID:15053981   PMID:15240886   PMID:15363417   PMID:15607939  
PMID:15618518   PMID:15653467   PMID:15691703   PMID:15705775   PMID:15761027   PMID:15930098   PMID:16020526   PMID:16055717   PMID:16061793   PMID:16129397   PMID:16141072   PMID:16141073  
PMID:16326147   PMID:16364899   PMID:16527264   PMID:16602821   PMID:16678101   PMID:16772167   PMID:16781703   PMID:16840539   PMID:16859901   PMID:17119020   PMID:17123502   PMID:17303810  
PMID:17311285   PMID:17331196   PMID:17359917   PMID:17359964   PMID:17367776   PMID:17392792   PMID:17488627   PMID:17492640   PMID:17604700   PMID:17605791   PMID:17616267   PMID:17728344  
PMID:17919533   PMID:18028107   PMID:18028108   PMID:18037398   PMID:18054242   PMID:18065432   PMID:18215620   PMID:18272476   PMID:18287559   PMID:18351662   PMID:18400164   PMID:18425848  
PMID:18534921   PMID:18539116   PMID:18583962   PMID:18586225   PMID:18662545   PMID:18775421   PMID:18927156   PMID:18940589   PMID:18942141   PMID:18996108   PMID:19004860   PMID:19093031  
PMID:19229337   PMID:19285468   PMID:19304889   PMID:19323994   PMID:19442735   PMID:19463901   PMID:19524524   PMID:19666821   PMID:19797899   PMID:19800948   PMID:19806666   PMID:19900438  
PMID:20008041   PMID:20463215   PMID:20826310   PMID:20932939   PMID:20934421   PMID:21040847   PMID:21068056   PMID:21149718   PMID:21215373   PMID:21247964   PMID:21248112   PMID:21267068  
PMID:21320481   PMID:21337666   PMID:21338882   PMID:21533046   PMID:21569850   PMID:21636786   PMID:21761479   PMID:21858141   PMID:21873635   PMID:21943603   PMID:22025611   PMID:22036570  
PMID:22159122   PMID:22343290   PMID:22421044   PMID:22542185   PMID:22629237   PMID:22649409   PMID:22833130   PMID:22836272   PMID:22844247   PMID:22848397   PMID:22945632   PMID:23103965  
PMID:23193182   PMID:23284914   PMID:23288907   PMID:23329048   PMID:23359544   PMID:23673330   PMID:23674600   PMID:23750000   PMID:23861948   PMID:23988635   PMID:24027269   PMID:24183897  
PMID:24227653   PMID:24267650   PMID:24333658   PMID:24485459   PMID:24496616   PMID:24948600   PMID:24952961   PMID:24995796   PMID:25179941   PMID:25392491   PMID:25543457   PMID:25668206  
PMID:25826454   PMID:25843547   PMID:25868900   PMID:25907274   PMID:25936505   PMID:25943695   PMID:26187199   PMID:26260513   PMID:26335645   PMID:26447474   PMID:26651607   PMID:26680198  
PMID:26764381   PMID:27184910   PMID:27210758   PMID:27226320   PMID:27477290   PMID:27568519   PMID:27939581   PMID:28082864   PMID:28139974   PMID:28451636   PMID:28579317   PMID:28807898  
PMID:28938441   PMID:29379870   PMID:29444423   PMID:29508544   PMID:29796621   PMID:29950673   PMID:30085028   PMID:30177510   PMID:30311912   PMID:30658714   PMID:30811539   PMID:30917309  
PMID:31077553   PMID:31305241   PMID:31427287   PMID:31822965   PMID:31968244   PMID:31969659   PMID:32325033   PMID:32453714   PMID:32937136   PMID:33787491   PMID:33795686   PMID:33869166  
PMID:34994686   PMID:35177643   PMID:35315772   PMID:35951005   PMID:36596814   PMID:36800350   PMID:37794731   PMID:37869988   PMID:38433925   PMID:38721990   PMID:38927675   PMID:38970652  
PMID:39001875   PMID:39289460  


Genomics

Comparative Map Data
Lhx3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39226,090,224 - 26,098,261 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl226,090,224 - 26,098,301 (-)EnsemblGRCm39 Ensembl
GRCm38226,200,212 - 26,208,249 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl226,200,212 - 26,208,289 (-)EnsemblGRCm38mm10GRCm38
MGSCv37226,055,732 - 26,062,076 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36226,022,956 - 26,030,258 (-)NCBIMGSCv36mm8
Celera225,922,727 - 25,929,069 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map218.44NCBI
LHX3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389136,196,250 - 136,205,128 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9136,196,250 - 136,205,128 (-)EnsemblGRCh38hg38GRCh38
GRCh379139,088,096 - 139,096,974 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369138,227,917 - 138,236,776 (-)NCBINCBI36Build 36hg18NCBI36
Build 349136,314,040 - 136,322,900NCBI
Celera9109,606,466 - 109,615,325 (-)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9108,552,281 - 108,560,958 (-)NCBIHuRef
CHM1_19139,236,859 - 139,245,718 (-)NCBICHM1_1
T2T-CHM13v2.09148,425,793 - 148,434,671 (-)NCBIT2T-CHM13v2.0
Lhx3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8329,424,620 - 29,432,637 (-)NCBIGRCr8
mRatBN7.239,026,432 - 9,035,122 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl39,027,425 - 9,034,480 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.033,653,861 - 3,662,509 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl33,654,755 - 3,661,810 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.039,015,656 - 9,023,734 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.434,381,890 - 4,389,132 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.134,387,210 - 4,387,304 (-)NCBI
Celera33,849,012 - 3,855,303 (-)NCBICelera
Cytogenetic Map3p13NCBI
Lhx3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555134,464,149 - 4,470,962 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555134,464,149 - 4,470,962 (+)NCBIChiLan1.0ChiLan1.0
LHX3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2113,179,178 - 3,188,054 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan193,181,513 - 3,190,389 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09107,271,131 - 107,280,001 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19136,252,974 - 136,260,366 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9136,252,880 - 136,260,366 (-)Ensemblpanpan1.1panPan2
LHX3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1949,248,555 - 49,254,128 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl949,248,621 - 49,254,118 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha948,499,054 - 48,504,456 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0950,125,225 - 50,131,690 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl950,125,225 - 50,130,622 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1948,905,665 - 48,911,059 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0949,199,965 - 49,205,359 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0949,247,527 - 49,252,929 (+)NCBIUU_Cfam_GSD_1.0
Lhx3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947201,802,058 - 201,811,080 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366691,564,102 - 1,573,047 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366691,561,433 - 1,573,074 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LHX3
(Sus scrofa - pig)		 No map positions available.
LHX3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,997,437 - 2,007,473 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl122,000,638 - 2,006,430 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660583,207,070 - 3,217,084 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lhx3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247601,429,384 - 1,435,414 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247601,428,496 - 1,435,414 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lhx3
305 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1320
Count of miRNA genes:516
Interacting mature miRNAs:665
Transcripts:ENSMUST00000028302, ENSMUST00000054099, ENSMUST00000127035, ENSMUST00000149637
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552706Cia24_mcollagen induced arthritis QTL 24 (mouse)Not determined22467911533523172Mouse
8552707Cia23_mcollagen induced arthritis QTL 23 (mouse)Not determined21212953766556453Mouse
1300624Insq7_minsulin QTL 7 (mouse)Not determined2938444643384575Mouse
8552705Cia25_mcollagen induced arthritis 25 (mouse)Not determined22467911533523172Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
26884438Sklq12_mskull length QTL 12, 16 week (mouse)22459001254890012Mouse
1301790Pcfm1_mperiosteal circumference and femur length 1 (mouse)Not determined2823629642236396Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
4142130Pgis2_mproteoglycan induced spondylitis 2 (mouse)Not determined22530805156971811Mouse
1301980Fcsa5_mfemoral cross-sectional area 5 (mouse)Not determined2767911541679261Mouse
1301376Etohc1_methanol consumption 1 (mouse)Not determined22112972555129871Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
12792980Fbmd1_mfemoral bone mineral density 1, females only (mouse)22503449245034492Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1301641Sbmd2_mspinal bone mineral density 2 (mouse)Not determined21421456748214713Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
1301838Sluc16_msusceptibility to lung cancer 16 (mouse)Not determined2126529589Mouse
10755513Amzn4_manatomical modifier of Zfp423 4 (mouse)2938444643384575Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
12904743Carcdq3_mcardiac collagen deposition QTL 3 (mouse)2323494028179150Mouse
13463470Tubisq1_mtubulointerstitial injury severity, QTL 1 (mouse)22368914557689269Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
4141708Pbwg1.2_mpostnatal body weight growth 1.2 (mouse)Not determined2112972555129871Mouse
10043876Adip22_madiposity 22 (mouse)Not determined2830805142308240Mouse
12903993Opfaq1_mopen field activity QTL 1 (mouse)2967669127022642Mouse

Markers in Region
L38248  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38226,200,347 - 26,200,457UniSTSGRCm38
MGSCv37226,055,867 - 26,055,977UniSTSGRCm37
Celera225,922,862 - 25,922,972UniSTS
Cytogenetic Map2A2-C1UniSTS
Whitehead/MRC_RH2443.37UniSTS
Lhx3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2A2-C1UniSTS
cM Map216.0UniSTS
UniSTS:225298  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38226,200,754 - 26,200,909UniSTSGRCm38
MGSCv37226,056,274 - 26,056,429UniSTSGRCm37
Celera225,923,269 - 25,923,424UniSTS
Cytogenetic Map2A2-C1UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000028302   ⟹   ENSMUSP00000028302
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl226,090,228 - 26,096,587 (-)Ensembl
GRCm38.p6 Ensembl226,200,216 - 26,206,575 (-)Ensembl
Ensembl Acc Id: ENSMUST00000054099   ⟹   ENSMUSP00000056822
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl226,090,224 - 26,098,301 (-)Ensembl
GRCm38.p6 Ensembl226,200,212 - 26,208,289 (-)Ensembl
Ensembl Acc Id: ENSMUST00000127035
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl226,090,228 - 26,092,878 (-)Ensembl
GRCm38.p6 Ensembl226,200,216 - 26,202,866 (-)Ensembl
Ensembl Acc Id: ENSMUST00000149637
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl226,092,488 - 26,093,453 (-)Ensembl
GRCm38.p6 Ensembl226,202,476 - 26,203,441 (-)Ensembl
RefSeq Acc Id: NM_001039653   ⟹   NP_001034742
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39226,090,224 - 26,096,587 (-)NCBI
GRCm38226,200,212 - 26,206,575 (-)NCBI
MGSCv37226,055,732 - 26,062,076 (-)RGD
Celera225,922,727 - 25,930,762 (-)NCBI
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_010711   ⟹   NP_034841
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39226,090,224 - 26,098,261 (-)NCBI
GRCm38226,200,212 - 26,208,249 (-)NCBI
Celera225,922,727 - 25,930,762 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011239031   ⟹   XP_011237333
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39226,090,224 - 26,094,031 (-)NCBI
GRCm38226,200,212 - 26,204,019 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001034742   ⟸   NM_001039653
- Peptide Label: isoform a
- UniProtKB: A2ALD8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_034841   ⟸   NM_010711
- Peptide Label: isoform b
- UniProtKB: Q61800 (UniProtKB/Swiss-Prot),   A2ALD9 (UniProtKB/Swiss-Prot),   Q61801 (UniProtKB/Swiss-Prot),   P50481 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011237333   ⟸   XM_011239031
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000056822   ⟸   ENSMUST00000054099
Ensembl Acc Id: ENSMUSP00000028302   ⟸   ENSMUST00000028302
Protein Domains
Homeobox   LIM zinc-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P50481-F1-model_v2 AlphaFold P50481 1-400 view protein structure

Promoters
RGD ID:6831693
Promoter ID:MM_KWN:28236
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:UC008IUI.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36226,063,431 - 26,063,931 (-)MPROMDB
RGD ID:6876676
Promoter ID:EPDNEW_M1789
Type:multiple initiation site
Name:Lhx3_2
Description:Mus musculus LIM homeobox protein 3 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M1790  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38226,206,562 - 26,206,622EPDNEW
RGD ID:6876678
Promoter ID:EPDNEW_M1790
Type:multiple initiation site
Name:Lhx3_1
Description:Mus musculus LIM homeobox protein 3 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M1789  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38226,208,288 - 26,208,348EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:102673 AgrOrtholog
Ensembl Genes ENSMUSG00000026934 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000028302 ENTREZGENE
  ENSMUST00000028302.8 UniProtKB/Swiss-Prot
  ENSMUST00000054099 ENTREZGENE
  ENSMUST00000054099.16 UniProtKB/Swiss-Prot
Gene3D-CATH Cysteine Rich Protein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lhx3/4-like_LIM2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lhx3_LIM1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM_Homeobox_TF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16871 UniProtKB/Swiss-Prot
MGD MGI:102673 ENTREZGENE
NCBI Gene 16871 ENTREZGENE
PANTHER LIM/HOMEOBOX PROTEIN LHX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM/HOMEOBOX PROTEIN LHX3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lhx3 PhenoGen
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM_DOMAIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM_DOMAIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2ALD8 ENTREZGENE, UniProtKB/TrEMBL
  A2ALD9 ENTREZGENE
  LHX3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q61800 ENTREZGENE
  Q61801 ENTREZGENE
  Q8C8F2_MOUSE UniProtKB/TrEMBL
UniProt Secondary A2ALD9 UniProtKB/Swiss-Prot
  Q61800 UniProtKB/Swiss-Prot
  Q61801 UniProtKB/Swiss-Prot