Smad2 (SMAD family member 2) - Rat Genome Database

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Gene: Smad2 (SMAD family member 2) Mus musculus
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Symbol: Smad2
Name: SMAD family member 2
RGD ID: 736957
MGI Page MGI
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding activity; and tau protein binding activity. Involved in several processes, including heart development; odontoblast differentiation; and positive regulation of epithelial to mesenchymal transition. Acts upstream of or within several processes, including cell surface receptor protein serine/threonine kinase signaling pathway; embryonic morphogenesis; and regulation of gene expression. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 6; Lynch syndrome; cervical cancer; and ovarian cancer. Orthologous to human SMAD2 (SMAD family member 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 7120426M23Rik; Mad; MAD homolog 2; mad-related protein 2; Madh; Madh2; Madr2; mMad2; mothers against decapentaplegic homolog 2; mothers against DPP homolog 2; RIKEN cDNA 7120426M23 gene; Smad 2; Smad-2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391876,369,898 - 76,444,819 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1876,374,651 - 76,444,034 (+)EnsemblGRCm39 Ensembl
GRCm381876,241,090 - 76,311,748 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1876,241,580 - 76,310,963 (+)EnsemblGRCm38mm10GRCm38
MGSCv371876,401,579 - 76,465,385 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361876,367,290 - 76,431,096 (+)NCBIMGSCv36mm8
Celera1877,499,761 - 77,546,271 (+)NCBICelera
Cytogenetic Map18E3NCBI
cM Map1851.42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(20S)-ginsenoside Rg3  (ISO)
(R)-lipoic acid  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-methoxyethanol  (ISO)
3,4-dihydroxybenzaldehyde  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-nitrophenol  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
aconitic acid  (EXP,ISO)
acteoside  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (ISO)
amlodipine  (ISO)
ammonium chloride  (ISO)
Ammothamnine  (EXP)
andrographolide  (EXP)
anthocyanin  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (ISO)
bellidifolin  (ISO)
benazepril  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-aminopropionitrile  (ISO)
beta-D-glucosamine  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (EXP)
bleomycin A2  (EXP,ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
camostat  (EXP)
carbofuran  (ISO)
carnosine  (ISO)
ceruletide  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
chromium atom  (ISO)
chrysin  (EXP)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP)
corticosterone  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
crocin-1  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP)
cytochalasin D  (ISO)
D-glucose  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
dibenziodolium  (ISO)
diethylstilbestrol  (EXP)
dimethyl sulfoxide  (ISO)
diminazene diaceturate  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enalapril  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
ethanol  (ISO)
etoposide  (ISO)
Evodiamine  (ISO)
farrerol  (ISO)
flutamide  (ISO)
folic acid  (EXP)
FR900359  (ISO)
galangin  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glucose  (ISO)
glycerol 2-phosphate  (EXP)
heptachlor  (ISO)
hispidin  (EXP)
Honokiol  (EXP,ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
irbesartan  (ISO)
Isoangustone A  (ISO)
isoprenaline  (ISO)
isorhamnetin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (EXP)
leptomycin B  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
LY-2157299  (EXP)
LY294002  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melphalan  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methimazole  (ISO)
methoxychlor  (ISO)
methyl beta-cyclodextrin  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (EXP)
nickel dichloride  (EXP)
niclosamide  (ISO)
nicotine  (ISO)
nitrates  (EXP)
nitrofen  (EXP)
ochratoxin A  (EXP,ISO)
oridonin  (ISO)
osthole  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
patulin  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phloroglucinol  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
Phyllanthin  (EXP)
platycodin D  (ISO)
procymidone  (ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
propofol  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
ramipril  (ISO)
resveratrol  (EXP,ISO)
rutin  (ISO)
salubrinal  (EXP)
SB 203580  (ISO)
SB 431542  (EXP,ISO)
serpentine asbestos  (ISO)
sevoflurane  (ISO)
silver(1+) nitrate  (ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium nitrite  (ISO)
Soman  (ISO)
sorafenib  (EXP)
streptozocin  (EXP,ISO)
sulfadimethoxine  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (EXP)
theobromine  (ISO)
theophylline  (ISO)
thioacetamide  (ISO)
Thrombin  (ISO)
titanium dioxide  (EXP)
tolfenamic acid  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
verapamil  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activin receptor signaling pathway  (IBA,ISO,NAS)
adrenal gland development  (IEA,ISO)
anatomical structure morphogenesis  (IBA)
anterior/posterior pattern specification  (IMP)
aortic valve morphogenesis  (IGI)
cell differentiation  (IBA)
cell fate commitment  (IMP)
cell population proliferation  (IGI)
cellular response to glucose stimulus  (IEA,ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
determination of left/right asymmetry in lateral mesoderm  (IEA,ISO)
developmental growth  (IGI)
embryonic cranial skeleton morphogenesis  (IGI)
embryonic foregut morphogenesis  (IGI)
embryonic pattern specification  (IGI)
endocardial cushion morphogenesis  (IGI)
endoderm development  (IGI)
endoderm formation  (IMP)
gastrulation  (IGI)
heart development  (IGI)
in utero embryonic development  (IGI,IMP)
insulin secretion  (IGI)
intracellular signal transduction  (IDA)
lung development  (IGI)
mesoderm formation  (IMP)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of DNA-templated transcription  (IEA,ISO)
negative regulation of gene expression  (IMP)
negative regulation of ossification  (IEA)
nodal signaling pathway  (IEA,ISO)
odontoblast differentiation  (IMP)
organ growth  (IGI)
pancreas development  (IGI)
paraxial mesoderm morphogenesis  (IMP)
pattern specification process  (IGI)
pericardium development  (IGI)
positive regulation of BMP signaling pathway  (IEA,ISO)
positive regulation of DNA-templated transcription  (IDA,IMP,ISO)
positive regulation of epithelial to mesenchymal transition  (IMP)
positive regulation of gene expression  (IMP)
positive regulation of transcription by RNA polymerase II  (IBA,IDA,IGI,ISO)
post-embryonic development  (IGI)
protein phosphorylation  (IDA,ISS)
pulmonary valve morphogenesis  (IGI)
regulation of DNA-templated transcription  (NAS)
regulation of transforming growth factor beta receptor signaling pathway  (IEA,ISO)
response to cholesterol  (IEA,ISO)
response to glucose  (IGI)
response to transforming growth factor beta  (IGI)
secondary palate development  (IMP)
signal transduction involved in regulation of gene expression  (IEA,ISO)
SMAD protein signal transduction  (IBA,IGI,ISO)
transforming growth factor beta receptor signaling pathway  (IBA,IDA,IGI,ISO,NAS)
trophoblast cell migration  (IEA)
ureteric bud development  (IEP)
zygotic specification of dorsal/ventral axis  (IEA,ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal anterior definitive endoderm morphology  (IAGP)
abnormal cell differentiation  (IAGP)
abnormal cell migration  (IAGP)
abnormal cell morphology  (IAGP)
abnormal cell physiology  (IAGP)
abnormal cerebellar foliation  (IAGP)
abnormal cerebellar granule cell migration  (IAGP)
abnormal cerebellar granule cell morphology  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal cerebellum vermis lobule IX morphology  (IAGP)
abnormal cerebellum vermis lobule X morphology  (IAGP)
abnormal chorion morphology  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal cumulus expansion  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal direction of embryo turning  (IAGP)
abnormal dorsal aorta morphology  (IAGP)
abnormal ectoplacental cone morphology  (IAGP)
abnormal egg cylinder morphology  (IAGP)
abnormal embryonic epiblast morphology  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal embryonic-extraembryonic boundary morphology  (IAGP)
abnormal endoderm development  (IAGP)
abnormal extraembryonic endoderm formation  (IAGP)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal eye development  (IAGP)
abnormal eye morphology  (IAGP)
abnormal forebrain development  (IAGP)
abnormal foregut morphology  (IAGP)
abnormal gait  (IAGP)
abnormal gastrulation  (IAGP)
abnormal heart development  (IAGP)
abnormal heart looping  (IAGP)
abnormal heart tube morphology  (IAGP)
abnormal hepatic cord morphology  (IAGP)
abnormal hepatoblast migration  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal hepatocyte physiology  (IAGP)
abnormal hindbrain development  (IAGP)
abnormal lateral plate mesoderm morphology  (IAGP)
abnormal left-right axis patterning  (IAGP)
abnormal liver morphology  (IAGP)
abnormal locomotor coordination  (IAGP)
abnormal mandible morphology  (IAGP)
abnormal Meckel's cartilage morphology  (IAGP)
abnormal olfactory epithelium morphology  (IAGP)
abnormal ovarian follicle morphology  (IAGP)
abnormal pericardial cavity morphology  (IAGP)
abnormal posture  (IAGP)
abnormal primitive streak elongation  (IAGP)
abnormal proamniotic cavity morphology  (IAGP)
abnormal proximal-distal axis patterning  (IAGP)
abnormal Purkinje cell dendrite morphology  (IAGP)
abnormal rostral-caudal axis patterning  (IAGP)
abnormal somite development  (IAGP)
abnormal visceral endoderm morphology  (IAGP)
abnormal wound healing  (IAGP)
absent allantois  (IAGP)
absent amnion  (IAGP)
absent chorion  (IAGP)
absent ectoderm  (IAGP)
absent endoderm  (IAGP)
absent extraembryonic ectoderm  (IAGP)
absent forebrain  (IAGP)
absent foregut  (IAGP)
absent head fold  (IAGP)
absent mandible  (IAGP)
absent mesoderm  (IAGP)
absent midbrain  (IAGP)
absent notochord  (IAGP)
absent optic placodes  (IAGP)
absent primitive node  (IAGP)
ataxia  (IAGP)
cyclopia  (IAGP)
decreased apoptosis  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mass  (IAGP)
decreased bone mineral content  (IAGP)
decreased CNS synapse formation  (IAGP)
decreased egg cylinder size  (IAGP)
decreased embryo size  (IAGP)
decreased hepatocyte proliferation  (IAGP)
decreased litter size  (IAGP)
decreased oocyte number  (IAGP)
decreased tertiary ovarian follicle number  (IAGP)
decreased tumor-free survival time  (IAGP)
delayed hepatic development  (IAGP)
dilated liver sinusoidal space  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality during organogenesis  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enhanced wound healing  (IAGP)
enlarged pericardium  (IAGP)
exencephaly  (IAGP)
failure of chorioallantoic fusion  (IAGP)
failure of primitive streak formation  (IAGP)
failure to gastrulate  (IAGP)
fused somites  (IAGP)
holoprosencephaly  (IAGP)
impaired balance  (IAGP)
increased atretic ovarian follicle number  (IAGP)
increased body weight  (IAGP)
increased bone mineral density  (IAGP)
increased circulating follicle stimulating hormone level  (IAGP)
increased circulating luteinizing hormone level  (IAGP)
increased erythrocyte cell number  (IAGP)
increased fetal size  (IAGP)
increased hepatocyte proliferation  (IAGP)
increased intestinal adenoma incidence  (IAGP)
increased keratinocyte migration  (IAGP)
increased lean body mass  (IAGP)
increased neuron apoptosis  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
limb grasping  (IAGP)
liver hypoplasia  (IAGP)
mandible hypoplasia  (IAGP)
microcephaly  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
osteoarthritis  (IAGP)
pericardial edema  (IAGP)
premature death  (IAGP)
premature ovarian failure  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
proboscis  (IAGP)
reduced female fertility  (IAGP)
right pulmonary isomerism  (IAGP)
rostral body truncation  (IAGP)
short stride length  (IAGP)
slow postnatal weight gain  (IAGP)
small liver  (IAGP)
small thyroid gland  (IAGP)
transposition of great arteries  (IAGP)
tremors  (IAGP)
truncated foregut  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Molecular mechanisms of TGF beta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506. Akool el-S, etal., J Immunol. 2008 Aug 15;181(4):2831-45.
2. Gene expression correlating with response to paclitaxel in ovarian carcinoma xenografts. Bani MR, etal., Mol Cancer Ther. 2004 Feb;3(2):111-21.
3. Cardioprotective role of growth/differentiation factor 1 in post-infarction left ventricular remodelling and dysfunction. Bao MW, etal., J Pathol. 2015 Jul;236(3):360-72. doi: 10.1002/path.4523. Epub 2015 Mar 30.
4. The development of a mouse model of ovarian endosalpingiosis. Bristol-Gould SK, etal., Endocrinology. 2005 Dec;146(12):5228-36. Epub 2005 Sep 1.
5. Transforming growth factor-beta pathway in human renal cell carcinoma and surrounding normal-appearing renal parenchyma. Cardillo MR, etal., Anal Quant Cytol Histol. 2001 Apr;23(2):109-17.
6. Ovarian follicle populations of the rat express TGF-beta signalling pathways. Drummond AE, etal., Mol Cell Endocrinol. 2003 Apr 28;202(1-2):53-7.
7. Interaction between angiotensin II and Smad proteins in fibroblasts in failing heart and in vitro. Hao J, etal., Am J Physiol Heart Circ Physiol. 2000 Dec;279(6):H3020-30.
8. [Changes in TGF-beta1/Smads signaling pathway in rats with chemical hepatocarcinogenesis]. Hua YP, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2008 Oct;28(10):1848-52.
9. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
10. Overexpression of Smad2 and colocalization with TGF-beta1 in human pancreatic cancer. Kleeff J, etal., Dig Dis Sci. 1999 Sep;44(9):1793-802.
11. Lefty1 Ameliorates Post-infarction Fibrosis by Suppressing p-Smad2 and p-ERK1/2 Signaling Pathways. Li CY, etal., J Cardiovasc Transl Res. 2021 Aug;14(4):636-646. doi: 10.1007/s12265-020-10089-2. Epub 2021 Jan 6.
12. cAMP inhibits transforming growth factor-beta-stimulated collagen synthesis via inhibition of extracellular signal-regulated kinase 1/2 and Smad signaling in cardiac fibroblasts. Liu X, etal., Mol Pharmacol. 2006 Dec;70(6):1992-2003. Epub 2006 Sep 7.
13. Loss of expression, and mutations of Smad 2 and Smad 4 in human cervical cancer. Maliekal TT, etal., Oncogene. 2003 Jul 31;22(31):4889-97.
14. TGFbeta in Cancer. Massagué J, Cell. 2008 Jul 25;134(2):215-30. doi: 10.1016/j.cell.2008.07.001.
15. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
16. MGDs mouse GO annotations MGD data from the GO Consortium
17. MGD IEA MGD IEA
18. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
19. Altered expression of Smad family members in injured motor neurons of rat. Okuyama N, etal., Brain Res. 2007 Feb 9;1132(1):36-41. Epub 2006 Dec 12.
20. cDNA cloning and chromosomal mapping of rat Smad2 and Smad4 and their expression in cultured rat articular chondrocytes. Osaki M, etal., Endocr J 1999 Oct;46(5):695-701.
21. Expression and intracellular localization of Smad proteins in human endometrial cancer. Piestrzeniewicz-Ulanska D, etal., Oncol Rep. 2003 Sep-Oct;10(5):1539-44.
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
24. Mouse MP Annotation Import Pipeline RGD automated import pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Mutation analysis of SMAD2, SMAD3, and SMAD4 genes in hereditary non-polyposis colorectal. Roth S, etal., J Med Genet. 2000 Apr;37(4):298-300.
28. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Shi Y and Massague J, Cell. 2003 Jun 13;113(6):685-700.
29. Oncopreventive effects of theanine and theobromine on dimethylhydrazine-induced colon cancer model. Shojaei-Zarghani S, etal., Biomed Pharmacother. 2021 Feb;134:111140. doi: 10.1016/j.biopha.2020.111140. Epub 2020 Dec 24.
30. MicroRNA-323-3p inhibits cell invasion and metastasis in pancreatic ductal adenocarcinoma via direct suppression of SMAD2 and SMAD3. Wang C, etal., Oncotarget. 2016 Mar 22;7(12):14912-24. doi: 10.18632/oncotarget.7482.
31. MicroRNA-31/184 is involved in transforming growth factor-β-induced apoptosis in A549 human alveolar adenocarcinoma cells. Wang CJ, etal., Life Sci. 2020 Feb 1;242:117205. doi: 10.1016/j.lfs.2019.117205. Epub 2019 Dec 23.
32. Analysis of specific gene mutations in the transforming growth factor-beta signal transduction pathway in human ovarian cancer. Wang D, etal., Cancer Res. 2000 Aug 15;60(16):4507-12.
33. Alterations of Smad signaling in human breast carcinoma are associated with poor outcome: a tissue microarray study. Xie W, etal., Cancer Res. 2002 Jan 15;62(2):497-505.
34. TGF-beta signaling alterations and susceptibility to colorectal cancer. Xu Y and Pasche B, Hum Mol Genet. 2007 Apr 15;16 Spec No 1:R14-20.
35. Altered gene expression profile in mouse bladder cancers induced by hydroxybutyl(butyl)nitrosamine. Yao R, etal., Neoplasia. 2004 Sep-Oct;6(5):569-77.
Additional References at PubMed
PMID:8756346   PMID:8917532   PMID:9328171   PMID:9529255   PMID:9566949   PMID:9655392   PMID:9689088   PMID:9702197   PMID:9858566   PMID:9921650   PMID:10030593   PMID:10341708  
PMID:10349617   PMID:10349636   PMID:10376010   PMID:10400677   PMID:10535967   PMID:10681527   PMID:10708952   PMID:10862745   PMID:11042159   PMID:11076861   PMID:11094085   PMID:11106407  
PMID:11160896   PMID:11169847   PMID:11195460   PMID:11285272   PMID:11418863   PMID:11438667   PMID:11456453   PMID:11478683   PMID:11544199   PMID:11557747   PMID:11703930   PMID:11711431  
PMID:11714685   PMID:11850197   PMID:11937490   PMID:11981827   PMID:11984875   PMID:12034730   PMID:12069494   PMID:12105419   PMID:12183405   PMID:12370310   PMID:12384562   PMID:12432092  
PMID:12477932   PMID:12520002   PMID:12584607   PMID:12588798   PMID:12672795   PMID:12782414   PMID:12799085   PMID:12815624   PMID:12839562   PMID:12842913   PMID:12880367   PMID:12904583  
PMID:12943993   PMID:14499634   PMID:14502566   PMID:14559231   PMID:14580334   PMID:14610273   PMID:14612425   PMID:14645149   PMID:14651998   PMID:14656760   PMID:14662776   PMID:14691138  
PMID:14701940   PMID:14729481   PMID:14734769   PMID:14749725   PMID:14764653   PMID:15059931   PMID:15084259   PMID:15084457   PMID:15133179   PMID:15135236   PMID:15150278   PMID:15183723  
PMID:15260977   PMID:15277382   PMID:15282343   PMID:15342483   PMID:15350225   PMID:15376321   PMID:15452874   PMID:15464984   PMID:15489334   PMID:15496141   PMID:15528466   PMID:15548585  
PMID:15566516   PMID:15599395   PMID:15618518   PMID:15630024   PMID:15630473   PMID:15649471   PMID:15657445   PMID:15744664   PMID:15761153   PMID:15799023   PMID:15849193   PMID:15883213  
PMID:15923624   PMID:15929941   PMID:15963972   PMID:15972691   PMID:15993878   PMID:16079159   PMID:16087734   PMID:16115198   PMID:16123376   PMID:16141072   PMID:16141073   PMID:16236725  
PMID:16317010   PMID:16322555   PMID:16382155   PMID:16407850   PMID:16435884   PMID:16455997   PMID:16477644   PMID:16602821   PMID:16607645   PMID:16619037   PMID:16780827   PMID:16790475  
PMID:16806156   PMID:16890162   PMID:16943282   PMID:16950122   PMID:16959237   PMID:17015622   PMID:17058229   PMID:17071578   PMID:17074756   PMID:17107998   PMID:17110447   PMID:17142805  
PMID:17159989   PMID:17168649   PMID:17192514   PMID:17272814   PMID:17341133   PMID:17389684   PMID:17392271   PMID:17429065   PMID:17431007   PMID:17452626   PMID:17460146   PMID:17467076  
PMID:17478422   PMID:17540976   PMID:17568773   PMID:17576802   PMID:17585069   PMID:17592132   PMID:17628518   PMID:17670744   PMID:17706958   PMID:17804598   PMID:17849440   PMID:17951260  
PMID:17967808   PMID:18005957   PMID:18024957   PMID:18029401   PMID:18063435   PMID:18079204   PMID:18089935   PMID:18095342   PMID:18184786   PMID:18210139   PMID:18212064   PMID:18258849  
PMID:18263591   PMID:18268325   PMID:18287559   PMID:18296617   PMID:18329379   PMID:18419760   PMID:18462697   PMID:18506886   PMID:18516051   PMID:18539926   PMID:18566469   PMID:18572160  
PMID:18618014   PMID:18648910   PMID:18653563   PMID:18725385   PMID:18763072   PMID:18764783   PMID:18799693   PMID:18809571   PMID:18950738   PMID:18952608   PMID:18974875   PMID:18990706  
PMID:19015235   PMID:19032363   PMID:19104148   PMID:19127219   PMID:19153222   PMID:19172185   PMID:19344627   PMID:19357234   PMID:19375497   PMID:19388084   PMID:19408651   PMID:19410550  
PMID:19419974   PMID:19448624   PMID:19465000   PMID:19465598   PMID:19488034   PMID:19498055   PMID:19509472   PMID:19517569   PMID:19556507   PMID:19580641   PMID:19587446   PMID:19604493  
PMID:19646988   PMID:19679673   PMID:19688838   PMID:19717565   PMID:19757385   PMID:19822523   PMID:19837676   PMID:19887954   PMID:19914168   PMID:19914233   PMID:19917253   PMID:19956733  
PMID:20007998   PMID:20019329   PMID:20059953   PMID:20096780   PMID:20211142   PMID:20346939   PMID:20382892   PMID:20404343   PMID:20412781   PMID:20488955   PMID:20530870   PMID:20548029  
PMID:20565978   PMID:20573697   PMID:20595680   PMID:20656683   PMID:20667820   PMID:20852387   PMID:20975697   PMID:21041365   PMID:21079647   PMID:21145499   PMID:21181942   PMID:21229365  
PMID:21252157   PMID:21267068   PMID:21300867   PMID:21308864   PMID:21419113   PMID:21437904   PMID:21454527   PMID:21464123   PMID:21466802   PMID:21482757   PMID:21496353   PMID:21518886  
PMID:21538804   PMID:21555266   PMID:21574244   PMID:21600798   PMID:21611174   PMID:21613609   PMID:21677750   PMID:21724602   PMID:21731500   PMID:21780244   PMID:21792478   PMID:21822279  
PMID:21856951   PMID:21873635   PMID:21880664   PMID:21937600   PMID:21939397   PMID:21957238   PMID:21976717   PMID:21979435   PMID:21990361   PMID:22045334   PMID:22072420   PMID:22179676  
PMID:22202673   PMID:22219364   PMID:22325351   PMID:22331441   PMID:22365545   PMID:22370000   PMID:22383895   PMID:22398790   PMID:22418736   PMID:22427664   PMID:22442258   PMID:22485132  
PMID:22498737   PMID:22560297   PMID:22698281   PMID:22699208   PMID:22710166   PMID:22723298   PMID:22767605   PMID:22783020   PMID:22842459   PMID:22880011   PMID:22918885   PMID:22964108  
PMID:22995554   PMID:23011393   PMID:23034635   PMID:23152446   PMID:23213481   PMID:23221368   PMID:23238123   PMID:23271656   PMID:23390484   PMID:23426374   PMID:23439432   PMID:23531444  
PMID:23546880   PMID:23562608   PMID:23585353   PMID:23592779   PMID:23603491   PMID:23620745   PMID:23622063   PMID:23649632   PMID:23651855   PMID:23741457   PMID:23742838   PMID:23747729  
PMID:23776616   PMID:23779087   PMID:23804438   PMID:23817199   PMID:23868013   PMID:23913959   PMID:23933588   PMID:23946498   PMID:23973329   PMID:23994637   PMID:24055172   PMID:24068386  
PMID:24071738   PMID:24086574   PMID:24089514   PMID:24108699   PMID:24238962   PMID:24259511   PMID:24308975   PMID:24347165   PMID:24357720   PMID:24373743   PMID:24424069   PMID:24449835  
PMID:24606313   PMID:24622514   PMID:24639504   PMID:24688224   PMID:24704361   PMID:24816837   PMID:24831012   PMID:24835278   PMID:24925688   PMID:24932701   PMID:24951251   PMID:24952961  
PMID:24964035   PMID:24996922   PMID:25023446   PMID:25092289   PMID:25141865   PMID:25146733   PMID:25150830   PMID:25155999   PMID:25170969   PMID:25185661   PMID:25249460   PMID:25274628  
PMID:25318679   PMID:25428587   PMID:25431176   PMID:25484855   PMID:25605784   PMID:25670798   PMID:25715398   PMID:25762570   PMID:25790465   PMID:25908723   PMID:25931117   PMID:25942106  
PMID:26019294   PMID:26023097   PMID:26116174   PMID:26120030   PMID:26141582   PMID:26151572   PMID:26194464   PMID:26202810   PMID:26354774   PMID:26367869   PMID:26420484   PMID:26435271  
PMID:26471094   PMID:26472242   PMID:26552887   PMID:26577380   PMID:26671461   PMID:26816051   PMID:26821812   PMID:26859889   PMID:26878215   PMID:26919280   PMID:26952977   PMID:26984772  
PMID:27012147   PMID:27067480   PMID:27129272   PMID:27164167   PMID:27177845   PMID:27180663   PMID:27215389   PMID:27224923   PMID:27329220   PMID:27336669   PMID:27362800   PMID:27398409  
PMID:27465829   PMID:27466203   PMID:27480124   PMID:27605619   PMID:27653694   PMID:27683557   PMID:27720610   PMID:27741240   PMID:27870967   PMID:27906099   PMID:27939132   PMID:27988204  
PMID:28009292   PMID:28064277   PMID:28076796   PMID:28095798   PMID:28099259   PMID:28115699   PMID:28153731   PMID:28170423   PMID:28191871   PMID:28375158   PMID:28378742   PMID:28380258  
PMID:28524854   PMID:28666967   PMID:28700594   PMID:28747678   PMID:28781074   PMID:28805484   PMID:28825193   PMID:28852052   PMID:28891814   PMID:28912269   PMID:29199516   PMID:29209813  
PMID:29247325   PMID:29561836   PMID:29574003   PMID:29651155   PMID:29689292   PMID:29743985   PMID:29930104   PMID:29945868   PMID:29952219   PMID:29981310   PMID:29986157   PMID:30030373  
PMID:30111581   PMID:30134160   PMID:30280598   PMID:30367168   PMID:30372567   PMID:30651315   PMID:30664861   PMID:30685387   PMID:30718289   PMID:30721632   PMID:30842446   PMID:30898767  
PMID:31068441   PMID:31155355   PMID:31174089   PMID:31218742   PMID:31241461   PMID:31311865   PMID:31334687   PMID:31366218   PMID:31422678   PMID:31499015   PMID:31647983   PMID:31677482  
PMID:31770533   PMID:31779270   PMID:31822518   PMID:31845891   PMID:32179057   PMID:32179481   PMID:32457763   PMID:32464258   PMID:32507875   PMID:32520726   PMID:32535965   PMID:32662771  
PMID:32827457   PMID:33171097   PMID:33248111   PMID:33436499   PMID:33462116   PMID:33548622   PMID:34129836   PMID:34157307   PMID:34210778   PMID:34237300   PMID:34270692   PMID:34273276  
PMID:34321999   PMID:34359912   PMID:34445177   PMID:34469723   PMID:34571833   PMID:34582892   PMID:34638474   PMID:34710825   PMID:34731499   PMID:34880220   PMID:35167946   PMID:35247391  
PMID:35359452   PMID:35456382   PMID:35503090   PMID:35593225   PMID:35780861   PMID:35894043   PMID:35895826   PMID:35946507   PMID:36050359   PMID:36227576   PMID:36314682   PMID:36435829  
PMID:36445780   PMID:36496409   PMID:36542062   PMID:37081156   PMID:37378449   PMID:37591240   PMID:37749326   PMID:37772583   PMID:37973188   PMID:38018454   PMID:38678560   PMID:38865240  
PMID:38925188   PMID:38951500   PMID:39190377   PMID:39286503   PMID:39702818   PMID:39772668   PMID:39868030   PMID:39955269  


Genomics

Comparative Map Data
Smad2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391876,369,898 - 76,444,819 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1876,374,651 - 76,444,034 (+)EnsemblGRCm39 Ensembl
GRCm381876,241,090 - 76,311,748 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1876,241,580 - 76,310,963 (+)EnsemblGRCm38mm10GRCm38
MGSCv371876,401,579 - 76,465,385 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361876,367,290 - 76,431,096 (+)NCBIMGSCv36mm8
Celera1877,499,761 - 77,546,271 (+)NCBICelera
Cytogenetic Map18E3NCBI
cM Map1851.42NCBI
SMAD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381847,808,957 - 47,930,872 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1847,808,957 - 47,931,146 (-)EnsemblGRCh38hg38GRCh38
GRCh371845,335,328 - 45,457,243 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361843,613,464 - 43,711,510 (-)NCBINCBI36Build 36hg18NCBI36
Build 341843,618,434 - 43,710,924NCBI
Celera1842,208,816 - 42,306,655 (-)NCBICelera
Cytogenetic Map18q21.1NCBI
HuRef1842,208,822 - 42,306,925 (-)NCBIHuRef
CHM1_11845,354,416 - 45,452,506 (-)NCBICHM1_1
T2T-CHM13v2.01847,999,960 - 48,121,861 (-)NCBIT2T-CHM13v2.0
Smad2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81872,124,792 - 72,193,345 (+)NCBIGRCr8
mRatBN7.21869,849,884 - 69,918,926 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1869,850,377 - 69,912,323 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1871,959,978 - 72,021,908 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01872,629,252 - 72,691,176 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01870,485,797 - 70,547,727 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01872,550,107 - 72,612,078 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1872,550,219 - 72,612,078 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01871,672,879 - 71,735,128 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41873,180,520 - 73,241,707 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11873,253,792 - 73,314,980 (+)NCBI
Celera1868,381,756 - 68,443,610 (+)NCBICelera
Cytogenetic Map18q12.3NCBI
Smad2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540233,136,778 - 33,216,844 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540233,131,760 - 33,217,144 (-)NCBIChiLan1.0ChiLan1.0
SMAD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21765,367,623 - 65,457,402 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11851,053,093 - 51,150,005 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01841,213,001 - 41,309,902 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11844,572,213 - 44,669,008 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1844,580,905 - 44,668,530 (-)Ensemblpanpan1.1panPan2
SMAD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1743,696,883 - 43,778,063 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl743,700,445 - 43,769,983 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha743,181,631 - 43,262,778 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0743,649,238 - 43,731,066 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl743,649,269 - 43,723,505 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1743,350,952 - 43,432,066 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0743,405,083 - 43,486,241 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0743,688,637 - 43,769,813 (+)NCBIUU_Cfam_GSD_1.0
Smad2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494439,484,164 - 39,562,655 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649714,723,199 - 14,801,697 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649714,723,199 - 14,812,160 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMAD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl197,415,716 - 97,511,357 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1197,415,360 - 97,511,388 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21106,898,131 - 106,991,500 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SMAD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11833,017,138 - 33,105,320 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1833,017,492 - 33,104,606 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660507,285,525 - 7,381,371 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Smad2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477811,384,769 - 11,501,078 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477811,380,656 - 11,460,566 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Smad2
2818 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:873
Count of miRNA genes:452
Interacting mature miRNAs:511
Transcripts:ENSMUST00000025453, ENSMUST00000091831, ENSMUST00000113930, ENSMUST00000165084, ENSMUST00000168423, ENSMUST00000171256, ENSMUST00000172198
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302099Hdlq30_mHDL QTL 30 (mouse)Not determined185166830085668468Mouse
11252137Modvl5_mmodifier of vacuolated lens 5 (mouse)185105215685052311Mouse
1558803W3q16_mweight 3 weeks QTL 16 (mouse)Not determined186127244881491831Mouse
10412244Par5_mpulmonary adenoma resistance 5 (mouse)Not determined185166830085668468Mouse
1301853Heal9_mwound healing/regeneration 9 (mouse)Not determined185280527686805416Mouse
1302109Sluc28_msusceptibility to lung cancer 28 (mouse)Not determined185993532190720763Mouse
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182489588178339555Mouse
1357639Obsty4_mobesity 4 (mouse)Not determined183961991484638778Mouse
4142443Pgis1_mproteoglycan induced spondylitis 1 (mouse)Not determined185329102276914293Mouse
4140971Mbmq1_mmale body mass QTL 1 (mouse)Not determined5799028190720763Mouse
1301902Hrtfm4_mheart failure modifier 4 (mouse)Not determined184331112077311343Mouse
12880410V125Dq13_mvitamin D active form serum level QTL 13 (mouse)185643307190433071Mouse
15014786Mvlq2_mmacrovesicular liver lesion QTL 2 (mouse)187156938890720763Mouse
12880428V125Dq14_mvitamin D active form serum level QTL 14 (mouse)185743307190720763Mouse
1558782Orgwq9_morgan weight QTL 9 (mouse)Not determined186127244882604728Mouse
1357630Tgq1_mtriglyceride QTL 1 (mouse)Not determined185105215685052311Mouse
12880430Fgf23lq4_mFGF23 serum level QTL 4 (mouse)185643307190433071Mouse
1301368Par2_mpulmonary adenoma resistance 2 (mouse)Not determined187036233376707156Mouse
11039492Ltpr8a_mLeishmania tropica response 8a (mouse)185918009290720763Mouse
12904745Carcdq2_mcardiac collagen deposition QTL 2 (mouse)184642328780423287Mouse
11039493Ltpr8d_mLeishmania tropica response 8d (mouse)184687490380875042Mouse
11039494Ltpr8b_mLeishmania tropica response 8b (mouse)184687490380875042Mouse
10401904Sicd4_mseizure-induced cell death 4 (mouse)Not determined186980527685514143Mouse
1301500Szs4_mseizure susceptibility 4 (mouse)Not determined185497587385514143Mouse
11039495Ltpr8c_mLeishmania tropica response 8c (mouse)185918009290720763Mouse
4141132Eae18_mexperimental allergic encephalomyelitis susceptibility 18 (mouse)Not determined5759055982604728Mouse
11049564Lmr29_mleishmaniasis resistance 29 (mouse)185918009290720763Mouse
38455998Cdtm1_mCD62L+ CD8 TM cells 1 (mouse)186013307280043215Mouse
1302183Pas7_mpulmonary adenoma susceptibility 7 (mouse)Not determined187274559484144595Mouse
1301798Hdlq31_mHDL QTL 31 (mouse)Not determined186714438990720763Mouse
4142153Idd21.1_minsulin dependent diabetes susceptibility 21.1 (mouse)Not determined187456233884144595Mouse
1301353Lbw6_mlupus NZB x NZW 6 (mouse)Not determined185756233890720763Mouse
1301103Pgia11_mproteoglycan induced arthritis 11 (mouse)Not determined185991418490720763Mouse

Markers in Region
Smad2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18E3UniSTS
cM Map1848.0UniSTS
BE686745  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381876,305,283 - 76,305,431UniSTSGRCm38
MGSCv371876,464,937 - 76,465,085UniSTSGRCm37
Celera1877,545,823 - 77,545,971UniSTS
Cytogenetic Map18E3UniSTS
cM Map1848.0UniSTS
Whitehead/MRC_RH18936.8UniSTS
RH126504  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381876,291,684 - 76,292,412UniSTSGRCm38
GRCm381876,291,684 - 76,291,933UniSTSGRCm38
MGSCv371876,451,338 - 76,452,066UniSTSGRCm37
MGSCv371876,451,338 - 76,451,587UniSTSGRCm37
Celera1877,532,213 - 77,532,462UniSTS
Celera1877,532,213 - 77,532,941UniSTS
Cytogenetic Map18E3UniSTS
cM Map1848.0UniSTS
Whitehead/MRC_RH18937.43UniSTS
AA858489  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381876,304,848 - 76,305,043UniSTSGRCm38
MGSCv371876,464,502 - 76,464,697UniSTSGRCm37
Celera1877,545,388 - 77,545,583UniSTS
Cytogenetic Map18E3UniSTS
cM Map1848.0UniSTS
PMC23005P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381876,262,291 - 76,262,513UniSTSGRCm38
MGSCv371876,421,945 - 76,422,167UniSTSGRCm37
Celera1877,499,612 - 77,499,834UniSTS
Cytogenetic Map18E3UniSTS
cM Map1848.0UniSTS
MARC_10275-10276:998924078:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381876,302,101 - 76,302,466UniSTSGRCm38
MGSCv371876,461,755 - 76,462,120UniSTSGRCm37
Celera1877,542,641 - 77,543,006UniSTS
Cytogenetic Map18E3UniSTS
cM Map1848.0UniSTS
Smad2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18E3UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001252481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001311070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006525699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017317842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030250351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC107768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC164009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF005743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK007817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK031111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK078612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV232667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY334552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC021342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM248478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU058005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN456711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U60530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000025453   ⟹   ENSMUSP00000025453
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1876,394,192 - 76,438,365 (+)Ensembl
GRCm38.p6 Ensembl1876,261,121 - 76,305,294 (+)Ensembl
Ensembl Acc Id: ENSMUST00000091831   ⟹   ENSMUSP00000089439
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1876,374,772 - 76,437,801 (+)Ensembl
GRCm38.p6 Ensembl1876,241,701 - 76,304,730 (+)Ensembl
Ensembl Acc Id: ENSMUST00000113930   ⟹   ENSMUSP00000109563
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1876,395,563 - 76,435,713 (+)Ensembl
GRCm38.p6 Ensembl1876,262,492 - 76,302,642 (+)Ensembl
Ensembl Acc Id: ENSMUST00000165084   ⟹   ENSMUSP00000132851
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1876,395,563 - 76,432,908 (+)Ensembl
GRCm38.p6 Ensembl1876,262,492 - 76,299,837 (+)Ensembl
Ensembl Acc Id: ENSMUST00000168423   ⟹   ENSMUSP00000130115
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1876,374,651 - 76,444,034 (+)Ensembl
GRCm38.p6 Ensembl1876,241,580 - 76,310,963 (+)Ensembl
Ensembl Acc Id: ENSMUST00000171256   ⟹   ENSMUSP00000125883
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1876,375,117 - 76,431,521 (+)Ensembl
GRCm38.p6 Ensembl1876,242,046 - 76,298,450 (+)Ensembl
Ensembl Acc Id: ENSMUST00000172198   ⟹   ENSMUSP00000129232
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1876,375,245 - 76,432,964 (+)Ensembl
GRCm38.p6 Ensembl1876,242,174 - 76,299,893 (+)Ensembl
RefSeq Acc Id: NM_001252481   ⟹   NP_001239410
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391876,394,192 - 76,444,818 (+)NCBI
GRCm381876,261,121 - 76,311,747 (+)NCBI
Celera1877,498,440 - 77,552,334 (+)ENTREZGENE
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001311070   ⟹   NP_001297999
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391876,395,516 - 76,444,818 (+)NCBI
GRCm381876,262,445 - 76,311,747 (+)NCBI
Sequence:
RefSeq Acc Id: NM_010754   ⟹   NP_034884
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391876,374,772 - 76,444,818 (+)NCBI
GRCm381876,241,701 - 76,311,747 (+)NCBI
MGSCv371876,401,579 - 76,465,385 (+)RGD
Celera1877,498,440 - 77,552,334 (+)ENTREZGENE
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006525699   ⟹   XP_006525762
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391876,375,183 - 76,444,819 (+)NCBI
GRCm381876,242,126 - 76,311,748 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017317842   ⟹   XP_017173331
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391876,369,898 - 76,444,819 (+)NCBI
GRCm381876,241,090 - 76,311,748 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030250351   ⟹   XP_030106211
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391876,375,154 - 76,444,819 (+)NCBI
GRCm381876,242,083 - 76,311,748 (+)NCBI
Sequence:
RefSeq Acc Id: NP_034884   ⟸   NM_010754
- Peptide Label: isoform 1
- UniProtKB: Q6VP00 (UniProtKB/Swiss-Prot),   Q6GU18 (UniProtKB/Swiss-Prot),   Q9D8P6 (UniProtKB/Swiss-Prot),   Q62432 (UniProtKB/Swiss-Prot),   E9Q3M0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001239410   ⟸   NM_001252481
- Peptide Label: isoform 1
- UniProtKB: Q6VP00 (UniProtKB/Swiss-Prot),   Q6GU18 (UniProtKB/Swiss-Prot),   Q9D8P6 (UniProtKB/Swiss-Prot),   Q62432 (UniProtKB/Swiss-Prot),   E9Q3M0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006525762   ⟸   XM_006525699
- Peptide Label: isoform X1
- UniProtKB: Q6VP00 (UniProtKB/Swiss-Prot),   Q6GU18 (UniProtKB/Swiss-Prot),   Q9D8P6 (UniProtKB/Swiss-Prot),   Q62432 (UniProtKB/Swiss-Prot),   E9Q3M0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017173331   ⟸   XM_017317842
- Peptide Label: isoform X2
- UniProtKB: E9Q3M0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001297999   ⟸   NM_001311070
- Peptide Label: isoform 2
- UniProtKB: E9Q3M0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030106211   ⟸   XM_030250351
- Peptide Label: isoform X2
- UniProtKB: E9Q3M0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000089439   ⟸   ENSMUST00000091831
Ensembl Acc Id: ENSMUSP00000129232   ⟸   ENSMUST00000172198
Ensembl Acc Id: ENSMUSP00000109563   ⟸   ENSMUST00000113930
Ensembl Acc Id: ENSMUSP00000125883   ⟸   ENSMUST00000171256
Ensembl Acc Id: ENSMUSP00000132851   ⟸   ENSMUST00000165084
Ensembl Acc Id: ENSMUSP00000130115   ⟸   ENSMUST00000168423
Ensembl Acc Id: ENSMUSP00000025453   ⟸   ENSMUST00000025453
Protein Domains
MH1   MH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62432-F1-model_v2 AlphaFold Q62432 1-467 view protein structure

Promoters
RGD ID:13678194
Promoter ID:EPDNEW_M23246
Type:initiation region
Name:Smad2_1
Description:Mus musculus SMAD family member 2 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M23247  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381876,241,696 - 76,241,756EPDNEW
RGD ID:13678196
Promoter ID:EPDNEW_M23247
Type:initiation region
Name:Smad2_2
Description:Mus musculus SMAD family member 2 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M23246  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381876,241,922 - 76,241,982EPDNEW
RGD ID:6829541
Promoter ID:MM_KWN:25722
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000025453,   ENSMUST00000091831
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361876,400,696 - 76,401,552 (+)MPROMDB
RGD ID:6829013
Promoter ID:MM_KWN:25725
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Lung
Transcripts:AK078612_7120426M23RIK,   AK079537_A230038B01RIK
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361876,470,634 - 76,471,134 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:108051 AgrOrtholog
Ensembl Genes ENSMUSG00000024563 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000025453 ENTREZGENE
  ENSMUST00000025453.15 UniProtKB/Swiss-Prot
  ENSMUST00000091831 ENTREZGENE
  ENSMUST00000091831.13 UniProtKB/Swiss-Prot
  ENSMUST00000113930 ENTREZGENE
  ENSMUST00000168423 ENTREZGENE
  ENSMUST00000168423.9 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.200.10 UniProtKB/Swiss-Prot
  3.90.520.10 UniProtKB/Swiss-Prot
InterPro Dwarfin UniProtKB/Swiss-Prot
  MAD_homology1_Dwarfin-type UniProtKB/Swiss-Prot
  MAD_homology_MH1 UniProtKB/Swiss-Prot
  SMAD-like_dom_sf UniProtKB/Swiss-Prot
  SMAD_dom_Dwarfin-type UniProtKB/Swiss-Prot
  SMAD_FHA_dom_sf UniProtKB/Swiss-Prot
  SMAD_MH1_sf UniProtKB/Swiss-Prot
KEGG Report mmu:17126 UniProtKB/Swiss-Prot
MGD MGI:108051 ENTREZGENE
NCBI Gene 17126 ENTREZGENE
PANTHER MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 2 UniProtKB/Swiss-Prot
  PTHR13703 UniProtKB/Swiss-Prot
Pfam MH1 UniProtKB/Swiss-Prot
  MH2 UniProtKB/Swiss-Prot
PhenoGen Smad2 PhenoGen
PROSITE MH1 UniProtKB/Swiss-Prot
  MH2 UniProtKB/Swiss-Prot
SMART DWA UniProtKB/Swiss-Prot
  DWB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49879 UniProtKB/Swiss-Prot
  SSF56366 UniProtKB/Swiss-Prot
UniProt E9PXA8_MOUSE UniProtKB/TrEMBL
  E9PZV6_MOUSE UniProtKB/TrEMBL
  E9Q3M0 ENTREZGENE, UniProtKB/TrEMBL
  E9Q5P9_MOUSE UniProtKB/TrEMBL
  Q62432 ENTREZGENE
  Q6GU18 ENTREZGENE
  Q6VP00 ENTREZGENE
  Q8C2P1_MOUSE UniProtKB/TrEMBL
  Q9D8P6 ENTREZGENE
  SMAD2_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q6GU18 UniProtKB/Swiss-Prot
  Q6VP00 UniProtKB/Swiss-Prot
  Q9D8P6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-04 Smad2  SMAD family member 2  7120426M23Rik  RIKEN cDNA 7120426M23 gene  Data merged from RGD:1613243 737654 PROVISIONAL
2012-07-10 Smad2  SMAD family member 2  Smad2  MAD homolog 2 (Drosophila)  Symbol and/or name change 5135510 APPROVED