SELE (selectin E) - Rat Genome Database

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Gene: SELE (selectin E) Homo sapiens
Analyze
Symbol: SELE
Name: selectin E
RGD ID: 736831
HGNC Page HGNC:10718
Description: Enables several functions, including oligosaccharide binding activity; phospholipase binding activity; and sialic acid binding activity. Involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; leukocyte tethering or rolling; and positive regulation of receptor internalization. Located in several cellular components, including caveola; clathrin-coated pit; and perinuclear region of cytoplasm. Implicated in IgA glomerulonephritis; brain ischemia; cerebrovascular disease; and coronary artery disease. Biomarker of COVID-19; rheumatic myocarditis; and type 1 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CD62 antigen-like family member E; CD62E; E-selectin; ELAM; ELAM-1; ELAM1; endothelial adhesion molecule 1; endothelial leukocyte adhesion molecule 1; ESEL; LECAM2; leukocyte endothelial cell adhesion molecule 2; leukocyte-endothelial cell adhesion molecule 2; selectin-e
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381169,722,640 - 169,734,079 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1169,722,640 - 169,764,705 (-)EnsemblGRCh38hg38GRCh38
GRCh371169,691,781 - 169,703,220 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361167,958,406 - 167,969,803 (-)NCBINCBI36Build 36hg18NCBI36
Build 341166,423,439 - 166,434,837NCBI
Celera1142,801,587 - 142,813,012 (-)NCBICelera
Cytogenetic Map1q24.2NCBI
HuRef1140,914,126 - 140,925,551 (-)NCBIHuRef
CHM1_11171,113,936 - 171,125,374 (-)NCBICHM1_1
T2T-CHM13v2.01169,078,428 - 169,089,853 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-Arctigenin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(20S)-ginsenoside Rh1  (EXP)
(25R)-cholest-5-ene-3beta,26-diol  (EXP)
(R)-linalyl acetate  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-colchicine  (ISO)
1,10-phenanthroline  (EXP)
1-nitropyrene  (EXP)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (EXP)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (EXP)
2-trans,6-trans-farnesyl diphosphate  (EXP)
22-Hydroxycholesterol  (EXP)
26-hydroxycholesterol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-dihydroxybenzoic acid  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
9-phenanthrol  (EXP)
acetamide  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate]  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP)
aluminium oxide  (EXP)
amiloride  (EXP)
ammonium chloride  (ISO)
antirheumatic drug  (EXP)
apigenin  (EXP)
apocynin  (EXP)
asbestos  (EXP)
aspalathin  (EXP)
atorvastatin calcium  (EXP)
beclomethasone  (EXP)
benzo[a]pyrene  (EXP)
bezafibrate  (EXP)
biotin  (ISO)
bisphenol A  (EXP,ISO)
budesonide  (EXP,ISO)
buta-1,3-diene  (ISO)
butanal  (EXP)
C60 fullerene  (ISO)
cadmium atom  (EXP)
cannabidiol  (ISO)
capsaicin  (ISO)
carbon nanotube  (EXP,ISO)
celastrol  (EXP)
celecoxib  (EXP)
CGP 52608  (EXP)
chenodeoxycholic acid  (EXP)
choline  (ISO)
chrysin  (EXP)
clobazam  (EXP)
clopidogrel  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
cordycepin  (EXP)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
D-mannitol  (EXP)
dabrafenib  (EXP)
decabromodiphenyl ether  (ISO)
deguelin  (EXP)
deoxycholic acid  (EXP)
desferrioxamine B  (EXP)
desflurane  (EXP)
dexamethasone  (EXP)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP)
edaravone  (ISO)
enalapril  (EXP)
Enterolactone  (EXP)
erythromycin A  (EXP)
ethanol  (ISO)
farnesyl diphosphate  (EXP)
fenofibrate  (EXP)
flavonoids  (ISO)
fluticasone  (EXP)
furan  (ISO)
galangin  (EXP)
gallic acid  (EXP)
gastrin-17  (EXP)
gentamycin  (ISO)
geranylgeraniol  (EXP)
ginkgolide B  (EXP)
ginsenoside C-K  (EXP)
glucose  (EXP)
glutathione  (EXP)
griseofulvin  (EXP)
GW 3965  (EXP)
GW 501516  (EXP)
hexadecanoic acid  (EXP)
hydrogen peroxide  (EXP)
hydroxytyrosol  (EXP)
ibuprofen  (EXP)
iron atom  (EXP)
iron(0)  (EXP)
isoprenaline  (EXP)
kaempferol  (EXP)
kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside  (EXP)
ketorolac  (ISO)
ketotifen  (EXP)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
linalool  (ISO)
linalyl acetate  (ISO)
lipopolysaccharide  (EXP,ISO)
luteolin  (EXP)
lycopene  (EXP)
malvidin 3-O-beta-D-glucoside  (EXP)
mangiferin  (ISO)
methotrexate  (EXP)
Methylthiouracil  (EXP)
mevalonic acid  (EXP)
mevastatin  (EXP)
microcystin-LR  (ISO)
mifepristone  (EXP)
MitoTEMPO  (EXP)
N-acetyl-beta-D-glucosamine  (ISO)
N-acetyl-D-glucosamine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
naproxen  (ISO)
nebivolol  (EXP)
neocuproine  (EXP)
nickel atom  (EXP)
nickel dichloride  (EXP)
nimesulide  (EXP)
nitric oxide  (EXP)
notoginsenoside R1  (ISO)
o-anisidine  (EXP)
ochratoxin A  (ISO)
oleanolic acid  (EXP)
oleuropein  (EXP)
oxytocin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parthenolide  (EXP)
perfluorooctanoic acid  (ISO)
phenytoin  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
pioglitazone  (ISO)
polymyxin B2  (EXP)
polyphosphates  (EXP)
PR-39  (ISO)
probucol  (EXP)
progesterone  (EXP)
quercetin  (EXP)
Quinupristin-dalfopristin  (EXP)
rebaudioside A  (EXP)
resveratrol  (EXP,ISO)
rolipram  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
SB 203580  (EXP)
sertraline  (EXP)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP)
sodium fluoride  (EXP)
steviol  (EXP)
stevioside  (EXP)
sulfasalazine  (EXP)
sumatriptan  (ISO)
tacrolimus hydrate  (ISO)
tebuconazole  (EXP)
tepoxalin  (ISO)
testosterone  (ISO)
tibolone  (EXP)
titanium dioxide  (EXP,ISO)
tofacitinib  (ISO)
trichloroethene  (ISO)
triptonide  (ISO)
trovafloxacin  (EXP,ISO)
valsartan  (EXP)
vincaleukoblastine  (ISO)
vincristine  (ISO)
vitamin E  (EXP)
wedelolactone  (EXP)
xanthohumol  (EXP)
zileuton  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. The interactive role of type 2 diabetes mellitus and E-selectin S128R mutation on susceptibility to coronary heart disease. Abu-Amero KK, etal., BMC Med Genet. 2007 Jun 20;8:35.
2. Imaging E-selectin expression following traumatic brain injury in the rat using a targeted USPIO contrast agent. Chapon C, etal., MAGMA. 2009 Jun;22(3):167-74. Epub 2008 Dec 24.
3. [Inhibiting effects of interleuin-10 on expression of E-selectin and L-selectin in cerebral ischemia-reperfusion: experiment with rats] Du HW, etal., Zhonghua Yi Xue Za Zhi. 2009 Jan 6;89(1):59-62.
4. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
5. Prediction of residual valvular lesions in rheumatic heart disease: role of adhesion molecules. Hafez M, etal., Pediatr Cardiol. 2013 Mar;34(3):583-90. doi: 10.1007/s00246-012-0501-7. Epub 2012 Sep 18.
6. A561C polymorphism of E-selectin is associated with ischemic cerebrovascular disease in the Japanese population without diabetes mellitus and hypercholesterolemia. Hattori H, etal., Brain Res. 2006 Sep 7;1108(1):221-3. Epub 2006 Jul 14.
7. Association of gene polymorphisms with coronary artery disease in low- or high-risk subjects defined by conventional risk factors. Hirashiki A, etal., J Am Coll Cardiol. 2003 Oct 15;42(8):1429-37.
8. Mucosal tolerance to E-selectin promotes the survival of newly generated neuroblasts via regulatory T-cell induction after stroke in spontaneously hypertensive rats. Ishibashi S, etal., J Cereb Blood Flow Metab. 2009 Mar;29(3):606-20. Epub 2008 Dec 24.
9. Association between the Ser128Arg variant of the E-selectin and risk of coronary artery disease in the central China. Li Y, etal., Int J Cardiol. 2005 Aug 3;103(1):33-6. Epub 2004 Dec 16.
10. Blood serum levels of vascular cell adhesion molecule (sVCAM-1), intercellular adhesion molecule (sICAM-1) and endothelial leucocyte adhesion molecule-1 (ELAM-1) in diabetic retinopathy. Nowak M, etal., Clin Exp Med. 2008 Sep;8(3):159-64. Epub 2008 Sep 13.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Accelerated development of arthritis in mice lacking endothelial selectins. Ruth JH, etal., Arthritis Res Ther. 2005;7(5):R959-70. Epub 2005 Jun 15.
17. Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients. Smadja DM, etal., Angiogenesis. 2020 May 27. pii: 10.1007/s10456-020-09730-0. doi: 10.1007/s10456-020-09730-0.
18. Association between single-nucleotide polymorphisms in selectin genes and immunoglobulin A nephropathy. Takei T, etal., Am J Hum Genet. 2002 Mar;70(3):781-6. Epub 2002 Feb 1.
19. Cell adhesion molecule mediation of myocardial inflammatory responses associated with ventricular pacing. Yamazaki KG, etal., Am J Physiol Heart Circ Physiol. 2012 Apr 1;302(7):H1387-93. doi: 10.1152/ajpheart.00496.2011. Epub 2012 Jan 20.
Additional References at PubMed
PMID:1375831   PMID:1689848   PMID:1694218   PMID:1701274   PMID:1703529   PMID:2466335   PMID:7509040   PMID:7523444   PMID:7533025   PMID:7536194   PMID:7538217   PMID:7541576  
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PMID:9597096   PMID:9920928   PMID:9933738   PMID:10391210   PMID:10419878   PMID:10477700   PMID:10982036   PMID:11097335   PMID:11168027   PMID:11341749   PMID:11359462   PMID:11402070  
PMID:11404363   PMID:11466561   PMID:11575217   PMID:11575218   PMID:11602579   PMID:11697721   PMID:11714857   PMID:11764211   PMID:11776680   PMID:11827962   PMID:11847011   PMID:11859093  
PMID:11882337   PMID:11882338   PMID:11929779   PMID:11935152   PMID:11936588   PMID:11948013   PMID:11981814   PMID:11983205   PMID:12011765   PMID:12020443   PMID:12027924   PMID:12036529  
PMID:12082590   PMID:12082592   PMID:12086338   PMID:12165498   PMID:12172318   PMID:12172576   PMID:12175121   PMID:12186696   PMID:12200076   PMID:12200386   PMID:12388172   PMID:12421968  
PMID:12477932   PMID:12499405   PMID:12522014   PMID:12595908   PMID:12626663   PMID:12649084   PMID:12673844   PMID:12698264   PMID:12738381   PMID:12768436   PMID:12788528   PMID:12792758  
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PMID:18704886   PMID:18707907   PMID:18710415   PMID:18726101   PMID:18761727   PMID:18794336   PMID:18828734   PMID:18930765   PMID:18973547   PMID:18974840   PMID:18974842   PMID:18991188  
PMID:19021457   PMID:19028820   PMID:19056482   PMID:19064610   PMID:19118161   PMID:19131662   PMID:19136145   PMID:19139603   PMID:19170196   PMID:19191721   PMID:19212205   PMID:19225544  
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PMID:36091666   PMID:36409296   PMID:36655409   PMID:37903858   PMID:38243063   PMID:38428409   PMID:38493006   PMID:38650162   PMID:39409189  


Genomics

Comparative Map Data
SELE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381169,722,640 - 169,734,079 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1169,722,640 - 169,764,705 (-)EnsemblGRCh38hg38GRCh38
GRCh371169,691,781 - 169,703,220 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361167,958,406 - 167,969,803 (-)NCBINCBI36Build 36hg18NCBI36
Build 341166,423,439 - 166,434,837NCBI
Celera1142,801,587 - 142,813,012 (-)NCBICelera
Cytogenetic Map1q24.2NCBI
HuRef1140,914,126 - 140,925,551 (-)NCBIHuRef
CHM1_11171,113,936 - 171,125,374 (-)NCBICHM1_1
T2T-CHM13v2.01169,078,428 - 169,089,853 (-)NCBIT2T-CHM13v2.0
Sele
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391163,867,200 - 163,886,056 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1163,875,773 - 163,885,246 (+)EnsemblGRCm39 Ensembl
GRCm381164,039,614 - 164,058,487 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1164,048,234 - 164,057,677 (+)EnsemblGRCm38mm10GRCm38
MGSCv371165,978,365 - 165,987,808 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361165,884,909 - 165,894,352 (+)NCBIMGSCv36mm8
Celera1166,489,844 - 166,499,312 (+)NCBICelera
Cytogenetic Map1H2.2NCBI
cM Map171.35NCBI
Sele
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81378,935,997 - 78,945,905 (+)NCBIGRCr8
mRatBN7.21376,402,841 - 76,412,741 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1376,403,304 - 76,412,741 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1379,021,472 - 79,031,290 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01380,325,949 - 80,335,341 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01377,580,536 - 77,589,930 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01382,355,234 - 82,365,323 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1382,355,471 - 82,365,341 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01387,234,842 - 87,244,746 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41379,813,455 - 79,822,845 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11379,827,642 - 79,837,033 (+)NCBI
Celera1376,136,932 - 76,146,318 (+)NCBICelera
Cytogenetic Map13q23NCBI
Sele
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554627,564,437 - 7,575,297 (+)NCBIChiLan1.0ChiLan1.0
SELE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2180,034,813 - 80,046,272 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1179,703,217 - 79,714,676 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01145,205,684 - 145,217,143 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11148,927,333 - 148,938,781 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1148,930,437 - 148,938,313 (-)Ensemblpanpan1.1panPan2
SELE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1728,888,503 - 28,898,787 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl728,888,197 - 28,898,786 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha728,420,727 - 28,430,555 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0728,690,348 - 28,700,684 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl728,690,094 - 28,700,681 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1728,538,997 - 28,548,824 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0728,574,705 - 28,584,533 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0728,811,713 - 28,821,538 (+)NCBIUU_Cfam_GSD_1.0
Sele
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934499,067,998 - 99,077,891 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648116,915,182 - 16,921,840 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648116,915,203 - 16,921,840 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SELE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1481,289,061 - 81,299,657 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2488,914,255 - 88,924,371 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SELE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12559,305,610 - 59,333,789 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2559,322,913 - 59,330,668 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605560,978,152 - 60,989,645 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sele
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248267,626,380 - 7,635,309 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248267,624,852 - 7,635,330 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SELE
54 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_000450.2(SELE):c.1402C>T (p.His468Tyr) single nucleotide variant IgA nephropathy, susceptibility to [RCV000018147] Chr1:169727805 [GRCh38]
Chr1:169696946 [GRCh37]
Chr1:1q24.2
uncertain significance
GRCh38/hg38 1q23.1-25.1(chr1:157747246-176021247)x3 copy number gain See cases [RCV000051854] Chr1:157747246..176021247 [GRCh38]
Chr1:157717036..175990383 [GRCh37]
Chr1:155983660..174257006 [NCBI36]
Chr1:1q23.1-25.1
pathogenic
GRCh38/hg38 1q23.3-25.2(chr1:164922655-180061589)x3 copy number gain See cases [RCV000051856] Chr1:164922655..180061589 [GRCh38]
Chr1:164891892..180030724 [GRCh37]
Chr1:163158516..178297347 [NCBI36]
Chr1:1q23.3-25.2
pathogenic
GRCh38/hg38 1q24.2-25.1(chr1:168314822-175299299)x1 copy number loss See cases [RCV000053918] Chr1:168314822..175299299 [GRCh38]
Chr1:168284060..175268435 [GRCh37]
Chr1:166550684..173535058 [NCBI36]
Chr1:1q24.2-25.1
pathogenic
GRCh38/hg38 1q24.2(chr1:169623984-169744043)x1 copy number loss See cases [RCV000053919] Chr1:169623984..169744043 [GRCh38]
Chr1:169593222..169713184 [GRCh37]
Chr1:167859846..167979808 [NCBI36]
Chr1:1q24.2
pathogenic
GRCh38/hg38 1q23.3-25.1(chr1:161740907-173965154)x1 copy number loss See cases [RCV000053914] Chr1:161740907..173965154 [GRCh38]
Chr1:161710697..173934292 [GRCh37]
Chr1:159977321..172200915 [NCBI36]
Chr1:1q23.3-25.1
pathogenic
GRCh38/hg38 1q23.3-24.3(chr1:164036599-171252077)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053916]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053916]|See cases [RCV000053916] Chr1:164036599..171252077 [GRCh38]
Chr1:164005836..171221216 [GRCh37]
Chr1:162272460..169487840 [NCBI36]
Chr1:1q23.3-24.3
pathogenic
GRCh38/hg38 1q24.1-25.1(chr1:166762832-175327423)x1 copy number loss See cases [RCV000053917] Chr1:166762832..175327423 [GRCh38]
Chr1:166732069..175296559 [GRCh37]
Chr1:164998693..173563182 [NCBI36]
Chr1:1q24.1-25.1
pathogenic
NM_000450.2(SELE):c.955C>T (p.His319Tyr) single nucleotide variant Malignant melanoma [RCV000059985] Chr1:169729321 [GRCh38]
Chr1:169698462 [GRCh37]
Chr1:167965086 [NCBI36]
Chr1:1q24.2
not provided
NM_000450.2(SELE):c.850C>T (p.Leu284Phe) single nucleotide variant Malignant melanoma [RCV000059986] Chr1:169729539 [GRCh38]
Chr1:169698680 [GRCh37]
Chr1:167965304 [NCBI36]
Chr1:1q24.2
not provided
NM_000450.2(SELE):c.1530C>G (p.Pro510=) single nucleotide variant Malignant melanoma [RCV000064301] Chr1:169727464 [GRCh38]
Chr1:169696605 [GRCh37]
Chr1:167963229 [NCBI36]
Chr1:1q24.2
not provided
NM_000450.2(SELE):c.999C>T (p.Phe333=) single nucleotide variant Malignant melanoma [RCV000064302] Chr1:169729277 [GRCh38]
Chr1:169698418 [GRCh37]
Chr1:167965042 [NCBI36]
Chr1:1q24.2
not provided
GRCh38/hg38 1q24.2-25.2(chr1:169218236-178075834)x1 copy number loss See cases [RCV000137128] Chr1:169218236..178075834 [GRCh38]
Chr1:169187474..178044969 [GRCh37]
Chr1:167454098..176311592 [NCBI36]
Chr1:1q24.2-25.2
pathogenic
GRCh38/hg38 1q23.3-25.1(chr1:163382523-175877022)x1 copy number loss See cases [RCV000143292] Chr1:163382523..175877022 [GRCh38]
Chr1:163352313..175846158 [GRCh37]
Chr1:161618937..174112781 [NCBI36]
Chr1:1q23.3-25.1
pathogenic
GRCh38/hg38 1q21.2-25.2(chr1:149854269-180267197)x3 copy number gain See cases [RCV000143515] Chr1:149854269..180267197 [GRCh38]
Chr1:149825831..180236332 [GRCh37]
Chr1:148092455..178502955 [NCBI36]
Chr1:1q21.2-25.2
pathogenic
GRCh37/hg19 1q24.2-25.3(chr1:169423492-180367623) copy number gain not provided [RCV000767621] Chr1:169423492..180367623 [GRCh37]
Chr1:1q24.2-25.3
pathogenic
GRCh37/hg19 1q23.3-25.3(chr1:161676893-184071723)x1 copy number loss See cases [RCV000447098] Chr1:161676893..184071723 [GRCh37]
Chr1:1q23.3-25.3
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
NM_000450.2(SELE):c.745G>T (p.Ala249Ser) single nucleotide variant not specified [RCV004314885] Chr1:169729644 [GRCh38]
Chr1:169698785 [GRCh37]
Chr1:1q24.2
uncertain significance
GRCh37/hg19 1q23.2-25.1(chr1:160369890-175796325) copy number loss not provided [RCV000767779] Chr1:160369890..175796325 [GRCh37]
Chr1:1q23.2-25.1
pathogenic
NM_000450.2(SELE):c.1688C>G (p.Ala563Gly) single nucleotide variant not specified [RCV004324786] Chr1:169726764 [GRCh38]
Chr1:169695905 [GRCh37]
Chr1:1q24.2
uncertain significance
NM_000450.2(SELE):c.1648C>T (p.Pro550Ser) single nucleotide variant not provided [RCV000768081] Chr1:169726804 [GRCh38]
Chr1:169695945 [GRCh37]
Chr1:1q24.2
uncertain significance
NM_000450.2(SELE):c.829G>A (p.Glu277Lys) single nucleotide variant not provided [RCV000768082] Chr1:169729560 [GRCh38]
Chr1:169698701 [GRCh37]
Chr1:1q24.2
uncertain significance
NM_000450.2(SELE):c.975C>A (p.Phe325Leu) single nucleotide variant not provided [RCV000768083] Chr1:169729301 [GRCh38]
Chr1:169698442 [GRCh37]
Chr1:1q24.2
uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1q23.2-25.2(chr1:159815642-177026983)x1 copy number loss not provided [RCV000736717] Chr1:159815642..177026983 [GRCh37]
Chr1:1q23.2-25.2
pathogenic
Single allele deletion 1q24q25 microdeletion syndrome [RCV000754969] Chr1:169095250..175778910 [GRCh37]
Chr1:1q24.2-25.1
pathogenic
NM_000450.2(SELE):c.624C>T (p.Ile208=) single nucleotide variant not provided [RCV000905608] Chr1:169730523 [GRCh38]
Chr1:169699664 [GRCh37]
Chr1:1q24.2
likely benign
NM_000450.2(SELE):c.1210T>C (p.Leu404=) single nucleotide variant not provided [RCV000892045] Chr1:169728127 [GRCh38]
Chr1:169697268 [GRCh37]
Chr1:1q24.2
benign
NM_000450.2(SELE):c.1260C>T (p.Asn420=) single nucleotide variant not provided [RCV000883027] Chr1:169728077 [GRCh38]
Chr1:169697218 [GRCh37]
Chr1:1q24.2
benign
NM_000450.2(SELE):c.901+9G>T single nucleotide variant not provided [RCV000768084] Chr1:169729479 [GRCh38]
Chr1:169698620 [GRCh37]
Chr1:1q24.2
uncertain significance
GRCh37/hg19 1q24.2-25.1(chr1:167430471-174635618)x1 copy number loss not provided [RCV001005149] Chr1:167430471..174635618 [GRCh37]
Chr1:1q24.2-25.1
pathogenic
NM_000450.2(SELE):c.31A>G (p.Thr11Ala) single nucleotide variant not specified [RCV004291655] Chr1:169733582 [GRCh38]
Chr1:169702723 [GRCh37]
Chr1:1q24.2
uncertain significance
NM_000450.2(SELE):c.967G>A (p.Gly323Arg) single nucleotide variant not specified [RCV004305052] Chr1:169729309 [GRCh38]
Chr1:169698450 [GRCh37]
Chr1:1q24.2
uncertain significance
NM_000450.2(SELE):c.1261G>C (p.Glu421Gln) single nucleotide variant not provided [RCV000972371] Chr1:169728076 [GRCh38]
Chr1:169697217 [GRCh37]
Chr1:1q24.2
benign
NM_000450.2(SELE):c.873T>C (p.Asn291=) single nucleotide variant not provided [RCV000953159] Chr1:169729516 [GRCh38]
Chr1:169698657 [GRCh37]
Chr1:1q24.2
benign
NM_000450.2(SELE):c.883G>A (p.Glu295Lys) single nucleotide variant not provided [RCV000888390] Chr1:169729506 [GRCh38]
Chr1:169698647 [GRCh37]
Chr1:1q24.2
benign
NM_000450.2(SELE):c.887A>C (p.Lys296Thr) single nucleotide variant not provided [RCV000971202] Chr1:169729502 [GRCh38]
Chr1:169729502..169729503 [GRCh38]
Chr1:169698643 [GRCh37]
Chr1:169698643..169698644 [GRCh37]
Chr1:1q24.2
likely benign
GRCh37/hg19 1q24.2(chr1:169148346-169806006)x1 copy number loss not provided [RCV001005151] Chr1:169148346..169806006 [GRCh37]
Chr1:1q24.2
uncertain significance
NC_000001.10:g.(?_130980840)_(248900000_?)dup duplication Gastrointestinal stromal tumor [RCV001300221]|Parathyroid carcinoma [RCV001341077] Chr1:130980840..248900000 [GRCh37]
Chr1:1q12-44
uncertain significance
NM_000450.2(SELE):c.1723C>T (p.Leu575Phe) single nucleotide variant Coronary artery disorder [RCV002245537]|not provided [RCV004715635] Chr1:169726729 [GRCh38]
Chr1:169695870 [GRCh37]
Chr1:1q24.2
benign
GRCh37/hg19 1q24.2-24.3(chr1:167391422-171843613) copy number loss not specified [RCV002053691] Chr1:167391422..171843613 [GRCh37]
Chr1:1q24.2-24.3
pathogenic
GRCh37/hg19 1q23.3-24.3(chr1:162330810-171532331) copy number loss not specified [RCV002053680] Chr1:162330810..171532331 [GRCh37]
Chr1:1q23.3-24.3
pathogenic
NC_000001.10:g.(?_169660781)_(170521603_?)del deletion not provided [RCV001972554] Chr1:169660781..170521603 [GRCh37]
Chr1:1q24.2
pathogenic
NM_000450.2(SELE):c.38-139T>C single nucleotide variant Coronary artery disorder [RCV002245536] Chr1:169733137 [GRCh38]
Chr1:169702278 [GRCh37]
Chr1:1q24.2
benign
NM_000450.2(SELE):c.865T>C (p.Ser289Pro) single nucleotide variant not specified [RCV004144009] Chr1:169729524 [GRCh38]
Chr1:169698665 [GRCh37]
Chr1:1q24.2
uncertain significance
NM_000450.2(SELE):c.473T>C (p.Ile158Thr) single nucleotide variant not specified [RCV004200214] Chr1:169731891 [GRCh38]
Chr1:169701032 [GRCh37]
Chr1:1q24.2
uncertain significance
NM_000450.2(SELE):c.596A>G (p.Asn199Ser) single nucleotide variant not specified [RCV004151620] Chr1:169730551 [GRCh38]
Chr1:169699692 [GRCh37]
Chr1:1q24.2
uncertain significance
NM_000450.2(SELE):c.1315G>A (p.Gly439Ser) single nucleotide variant not specified [RCV004105042] Chr1:169727892 [GRCh38]
Chr1:169697033 [GRCh37]
Chr1:1q24.2
uncertain significance
NM_000450.2(SELE):c.272C>G (p.Thr91Arg) single nucleotide variant not specified [RCV004171357] Chr1:169732764 [GRCh38]
Chr1:169701905 [GRCh37]
Chr1:1q24.2
uncertain significance
NM_000450.2(SELE):c.1390G>C (p.Gly464Arg) single nucleotide variant not specified [RCV004113518] Chr1:169727817 [GRCh38]
Chr1:169696958 [GRCh37]
Chr1:1q24.2
uncertain significance
NM_000450.2(SELE):c.404T>C (p.Leu135Pro) single nucleotide variant not specified [RCV004164385] Chr1:169732632 [GRCh38]
Chr1:169701773 [GRCh37]
Chr1:1q24.2
uncertain significance
NM_000450.2(SELE):c.1379G>C (p.Ser460Thr) single nucleotide variant not specified [RCV004215408] Chr1:169727828 [GRCh38]
Chr1:169696969 [GRCh37]
Chr1:1q24.2
uncertain significance
NM_000450.2(SELE):c.668A>T (p.Gln223Leu) single nucleotide variant not specified [RCV004159906] Chr1:169730479 [GRCh38]
Chr1:169699620 [GRCh37]
Chr1:1q24.2
uncertain significance
NM_000450.2(SELE):c.656T>C (p.Met219Thr) single nucleotide variant not specified [RCV004201311] Chr1:169730491 [GRCh38]
Chr1:169699632 [GRCh37]
Chr1:1q24.2
likely benign
NM_000450.2(SELE):c.1228C>T (p.Leu410Phe) single nucleotide variant not specified [RCV004075030] Chr1:169728109 [GRCh38]
Chr1:169697250 [GRCh37]
Chr1:1q24.2
uncertain significance
NM_000450.2(SELE):c.1247G>C (p.Gly416Ala) single nucleotide variant not specified [RCV004069574] Chr1:169728090 [GRCh38]
Chr1:169697231 [GRCh37]
Chr1:1q24.2
uncertain significance
NM_000450.2(SELE):c.1783C>G (p.Gln595Glu) single nucleotide variant not specified [RCV004182027] Chr1:169725794 [GRCh38]
Chr1:169694935 [GRCh37]
Chr1:1q24.2
uncertain significance
NM_000450.2(SELE):c.494G>A (p.Cys165Tyr) single nucleotide variant not specified [RCV004264850] Chr1:169731870 [GRCh38]
Chr1:169701011 [GRCh37]
Chr1:1q24.2
uncertain significance
NM_000450.2(SELE):c.142G>A (p.Val48Ile) single nucleotide variant not specified [RCV004252824] Chr1:169732894 [GRCh38]
Chr1:169702035 [GRCh37]
Chr1:1q24.2
uncertain significance
NM_000450.2(SELE):c.227A>G (p.Lys76Arg) single nucleotide variant not specified [RCV004275832] Chr1:169732809 [GRCh38]
Chr1:169701950 [GRCh37]
Chr1:1q24.2
uncertain significance
NM_000450.2(SELE):c.1031C>A (p.Pro344Gln) single nucleotide variant not specified [RCV004264261] Chr1:169729245 [GRCh38]
Chr1:169698386 [GRCh37]
Chr1:1q24.2
uncertain significance
NM_000450.2(SELE):c.836T>C (p.Met279Thr) single nucleotide variant not specified [RCV004365141] Chr1:169729553 [GRCh38]
Chr1:169698694 [GRCh37]
Chr1:1q24.2
uncertain significance
NM_000450.2(SELE):c.100G>C (p.Asp34His) single nucleotide variant not specified [RCV004359080] Chr1:169732936 [GRCh38]
Chr1:169702077 [GRCh37]
Chr1:1q24.2
uncertain significance
GRCh37/hg19 1q23.3-25.1(chr1:164571371-175708060)x1 copy number loss not provided [RCV003483966] Chr1:164571371..175708060 [GRCh37]
Chr1:1q23.3-25.1
pathogenic
GRCh37/hg19 1q24.2-31.1(chr1:167994071-187711459)x1 copy number loss not specified [RCV003987250] Chr1:167994071..187711459 [GRCh37]
Chr1:1q24.2-31.1
pathogenic
NM_000450.2(SELE):c.1490C>T (p.Ala497Val) single nucleotide variant not specified [RCV004447831] Chr1:169727504 [GRCh38]
Chr1:169696645 [GRCh37]
Chr1:1q24.2
uncertain significance
NM_000450.2(SELE):c.638G>A (p.Gly213Asp) single nucleotide variant not specified [RCV004447834] Chr1:169730509 [GRCh38]
Chr1:169699650 [GRCh37]
Chr1:1q24.2
uncertain significance
NM_000450.2(SELE):c.646C>A (p.Pro216Thr) single nucleotide variant not specified [RCV004447835] Chr1:169730501 [GRCh38]
Chr1:169699642 [GRCh37]
Chr1:1q24.2
uncertain significance
NM_000450.2(SELE):c.1295C>G (p.Ala432Gly) single nucleotide variant not specified [RCV004447830] Chr1:169727912 [GRCh38]
Chr1:169697053 [GRCh37]
Chr1:1q24.2
uncertain significance
NM_000450.2(SELE):c.1124G>A (p.Arg375Gln) single nucleotide variant not specified [RCV004447829] Chr1:169728213 [GRCh38]
Chr1:169697354 [GRCh37]
Chr1:1q24.2
uncertain significance
NM_000450.2(SELE):c.1735C>T (p.Arg579Trp) single nucleotide variant not specified [RCV004447833] Chr1:169726717 [GRCh38]
Chr1:169695858 [GRCh37]
Chr1:1q24.2
uncertain significance
NM_000450.2(SELE):c.1583G>A (p.Gly528Asp) single nucleotide variant not specified [RCV004447832] Chr1:169727411 [GRCh38]
Chr1:169696552 [GRCh37]
Chr1:1q24.2
uncertain significance
NM_000450.2(SELE):c.932A>G (p.Gln311Arg) single nucleotide variant not specified [RCV004447836] Chr1:169729344 [GRCh38]
Chr1:169698485 [GRCh37]
Chr1:1q24.2
uncertain significance
NM_000450.2(SELE):c.1748G>A (p.Arg583Gln) single nucleotide variant not specified [RCV004667054] Chr1:169726704 [GRCh38]
Chr1:169695845 [GRCh37]
Chr1:1q24.2
uncertain significance
NM_000450.2(SELE):c.563A>G (p.His188Arg) single nucleotide variant not specified [RCV004667055] Chr1:169730584 [GRCh38]
Chr1:169699725 [GRCh37]
Chr1:1q24.2
uncertain significance
NM_000450.2(SELE):c.355G>A (p.Glu119Lys) single nucleotide variant not specified [RCV004663711] Chr1:169732681 [GRCh38]
Chr1:169701822 [GRCh37]
Chr1:1q24.2
uncertain significance
NM_000450.2(SELE):c.1520G>A (p.Ser507Asn) single nucleotide variant not specified [RCV004667053] Chr1:169727474 [GRCh38]
Chr1:169696615 [GRCh37]
Chr1:1q24.2
uncertain significance
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR31hsa-miR-31-5pMirtarbaseexternal_infoImmunocytochemistry//Northern blot//qRT-PCR//WesteFunctional MTI19949084
MIR17hsa-miR-17-3pMirtarbaseexternal_infoLuciferase reporter assayNon-Functional MTI19949084

Predicted Target Of
Summary Value
Count of predictions:6144
Count of miRNA genes:786
Interacting mature miRNAs:918
Transcripts:ENST00000333360, ENST00000367774, ENST00000367775, ENST00000367776, ENST00000367777, ENST00000367779, ENST00000367780, ENST00000367781, ENST00000367782, ENST00000461085, ENST00000609271
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D1S332  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371169,693,096 - 169,693,570UniSTSGRCh37
Build 361167,959,720 - 167,960,194RGDNCBI36
Celera1142,802,902 - 142,803,376RGD
Cytogenetic Map1q22-q25UniSTS
HuRef1140,915,441 - 140,915,915UniSTS
GDB:592877  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371169,700,937 - 169,701,122UniSTSGRCh37
Build 361167,967,561 - 167,967,746RGDNCBI36
Celera1142,810,729 - 142,810,914RGD
Cytogenetic Map1q22-q25UniSTS
HuRef1140,923,268 - 140,923,453UniSTS
PMC97258P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371169,700,985 - 169,701,911UniSTSGRCh37
Build 361167,967,609 - 167,968,535RGDNCBI36
Celera1142,810,777 - 142,811,703RGD
Cytogenetic Map1q22-q25UniSTS
HuRef1140,923,316 - 140,924,242UniSTS
D1S3668  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371169,705,073 - 169,705,185UniSTSGRCh37
Build 361167,971,697 - 167,971,809RGDNCBI36
Celera1142,814,865 - 142,814,977RGD
HuRef1140,927,404 - 140,927,516UniSTS
RH17688  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371169,692,084 - 169,692,246UniSTSGRCh37
Build 361167,958,708 - 167,958,870RGDNCBI36
Celera1142,801,890 - 142,802,052RGD
Cytogenetic Map1q22-q25UniSTS
HuRef1140,914,429 - 140,914,591UniSTS
GeneMap99-GB4 RH Map1610.96UniSTS
D1S3363  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371169,693,318 - 169,693,436UniSTSGRCh37
Build 361167,959,942 - 167,960,060RGDNCBI36
Celera1142,803,124 - 142,803,242RGD
Cytogenetic Map1q22-q25UniSTS
HuRef1140,915,663 - 140,915,781UniSTS
Stanford-G3 RH Map16563.0UniSTS
GeneMap99-GB4 RH Map1612.61UniSTS
Whitehead-RH Map1759.5UniSTS
Whitehead-YAC Contig Map1 UniSTS
NCBI RH Map11497.8UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1204 2314 2755 2215 4556 1681 2101 2 596 1239 434 2030 6377 5728 5 3546 787 1624 1401 164

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_012124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF540378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL021940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY367062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC131551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC142677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC142711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB209354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC700332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M24736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M30640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M64485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OM273722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OR395551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000333360   ⟹   ENSP00000331736
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1169,722,640 - 169,734,079 (-)Ensembl
Ensembl Acc Id: ENST00000367774   ⟹   ENSP00000356748
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1169,725,729 - 169,733,660 (-)Ensembl
Ensembl Acc Id: ENST00000367775   ⟹   ENSP00000356749
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1169,722,641 - 169,733,659 (-)Ensembl
Ensembl Acc Id: ENST00000367776   ⟹   ENSP00000356750
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1169,722,641 - 169,733,660 (-)Ensembl
Ensembl Acc Id: ENST00000367777   ⟹   ENSP00000356751
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1169,722,641 - 169,733,660 (-)Ensembl
Ensembl Acc Id: ENST00000461085
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1169,731,491 - 169,732,718 (-)Ensembl
Ensembl Acc Id: ENST00000609271   ⟹   ENSP00000476784
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1169,733,577 - 169,764,705 (-)Ensembl
RefSeq Acc Id: NM_000450   ⟹   NP_000441
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381169,722,640 - 169,734,079 (-)NCBI
GRCh371169,691,781 - 169,703,220 (-)ENTREZGENE
Build 361167,958,406 - 167,969,803 (-)NCBI Archive
HuRef1140,914,126 - 140,925,551 (-)ENTREZGENE
CHM1_11171,113,936 - 171,125,374 (-)NCBI
T2T-CHM13v2.01169,078,428 - 169,089,853 (-)NCBI
Sequence:
RefSeq Acc Id: NP_000441   ⟸   NM_000450
- Peptide Label: precursor
- UniProtKB: A2RRD6 (UniProtKB/Swiss-Prot),   P16111 (UniProtKB/Swiss-Prot),   P16581 (UniProtKB/Swiss-Prot),   B2RAJ1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000476784   ⟸   ENST00000609271
Ensembl Acc Id: ENSP00000331736   ⟸   ENST00000333360
Ensembl Acc Id: ENSP00000356749   ⟸   ENST00000367775
Ensembl Acc Id: ENSP00000356748   ⟸   ENST00000367774
Ensembl Acc Id: ENSP00000356751   ⟸   ENST00000367777
Ensembl Acc Id: ENSP00000356750   ⟸   ENST00000367776
Protein Domains
C-type lectin   EGF-like   Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P16581-F1-model_v2 AlphaFold P16581 1-610 view protein structure

Promoters
RGD ID:6858076
Promoter ID:EPDNEW_H2203
Type:single initiation site
Name:SELE_1
Description:selectin E
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381169,734,079 - 169,734,139EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:10718 AgrOrtholog
COSMIC SELE COSMIC
Ensembl Genes ENSG00000007908 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000333360 ENTREZGENE
  ENST00000333360.12 UniProtKB/Swiss-Prot
  ENST00000367774.1 UniProtKB/TrEMBL
  ENST00000367775.5 UniProtKB/TrEMBL
  ENST00000367776.5 UniProtKB/TrEMBL
  ENST00000367777.5 UniProtKB/TrEMBL
  ENST00000609271.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000007908 GTEx
HGNC ID HGNC:10718 ENTREZGENE
Human Proteome Map SELE Human Proteome Map
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Compl-Cell_Adhes-Reg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Selectin_CTLD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Selectin_superfamily UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:6401 UniProtKB/Swiss-Prot
NCBI Gene 6401 ENTREZGENE
OMIM 131210 OMIM
PANTHER COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  E-SELECTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA35640 PharmGKB
PRINTS SELECTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE C_TYPE_LECTIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUSHI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CCP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57535 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2RRD6 ENTREZGENE
  B2RAJ1 ENTREZGENE, UniProtKB/TrEMBL
  LYAM2_HUMAN UniProtKB/Swiss-Prot
  P16111 ENTREZGENE
  P16581 ENTREZGENE
  Q5TI72_HUMAN UniProtKB/TrEMBL
  Q5TI73_HUMAN UniProtKB/TrEMBL
  Q5TI74_HUMAN UniProtKB/TrEMBL
  Q5TI75_HUMAN UniProtKB/TrEMBL
  V9GYI4_HUMAN UniProtKB/TrEMBL
UniProt Secondary A2RRD6 UniProtKB/Swiss-Prot
  P16111 UniProtKB/Swiss-Prot