GCLC Human (+)-catechin multiple interactions EXP 6480464 [Oxygen deficiency co-treated with Catechin] results in increased expression of GCLC mRNA CTD PMID:35883890 GCLC Human (+)-schisandrin B increases activity ISO Gclc (Rattus norvegicus) 6480464 schizandrin B analog results in increased activity of GCLC protein CTD PMID:21328628 GCLC Human (+)-schisandrin B multiple interactions ISO Gclc (Rattus norvegicus) 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of GCLC mRNA] CTD PMID:31150632 GCLC Human (+/-)-Aegeline multiple interactions ISO Gclc (Mus musculus) 6480464 [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GCLC mRNA CTD PMID:28843594 GCLC Human (-)-epigallocatechin 3-gallate increases expression ISO Gclc (Mus musculus) 6480464 epigallocatechin gallate results in increased expression of GCLC mRNA CTD PMID:25585349 GCLC Human (-)-epigallocatechin 3-gallate multiple interactions EXP 6480464 [arsenite co-treated with epigallocatechin gallate] results in increased expression of GCLC protein CTD PMID:29572906 GCLC Human (1->4)-beta-D-glucan multiple interactions ISO Gclc (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of GCLC mRNA CTD PMID:36331819 GCLC Human (2,4,5-trichlorophenoxy)acetic acid increases expression EXP 6480464 2 more ... CTD PMID:16426233 GCLC Human (2,4,5-trichlorophenoxy)acetic acid increases expression ISO Gclc (Mus musculus) 6480464 2 more ... CTD PMID:10377250 and PMID:16426233 GCLC Human (E)-cinnamyl alcohol increases expression EXP 6480464 cinnamyl alcohol results in increased expression of GCLC mRNA CTD PMID:20566472 GCLC Human (R)-lipoic acid increases expression EXP 6480464 Thioctic Acid results in increased expression of GCLC mRNA CTD PMID:16249512 more ... GCLC Human (R)-lipoic acid multiple interactions EXP 6480464 Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLC mRNA] and Thioctic Acid results in increased expression of and results in increased activity of GCLC protein CTD PMID:26365678 GCLC Human (R)-lipoic acid multiple interactions ISO Gclc (Mus musculus) 6480464 Thioctic Acid inhibits the reaction [Silicon results in decreased expression of GCLC protein] CTD PMID:34252510 GCLC Human (R)-lipoic acid multiple interactions ISO Gclc (Rattus norvegicus) 6480464 Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GCLC protein] more ... CTD PMID:27298056 and PMID:32061141 GCLC Human (R,R,R)-alpha-tocopherol multiple interactions EXP 6480464 [alpha-Tocopherol co-treated with Paraquat] results in increased expression of GCLC mRNA CTD PMID:24530478 GCLC Human (RS)-coclaurine multiple interactions ISO Gclc (Mus musculus) 6480464 [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GCLC mRNA CTD PMID:28843594 GCLC Human (RS)-norcoclaurine multiple interactions ISO Gclc (Mus musculus) 6480464 [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GCLC mRNA CTD PMID:28843594 GCLC Human (S)-coclaurine multiple interactions ISO Gclc (Mus musculus) 6480464 [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GCLC mRNA CTD PMID:28843594 GCLC Human (S)-colchicine multiple interactions ISO Gclc (Mus musculus) 6480464 Colchicine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA] CTD PMID:37573684 GCLC Human (S)-naringenin increases expression EXP 6480464 naringenin results in increased expression of GCLC protein CTD PMID:31254498 GCLC Human (S)-naringenin multiple interactions EXP 6480464 NFE2L2 protein affects the reaction [naringenin results in increased expression of GCLC protein] CTD PMID:31254498 GCLC Human (S)-nicotine multiple interactions ISO Gclc (Mus musculus) 6480464 [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 GCLC Human 1,1'-azobis(N,N-dimethylformamide) increases activity ISO Gclc (Rattus norvegicus) 6480464 Diamide results in increased activity of GCLC protein CTD PMID:15115889 GCLC Human 1,1'-azobis(N,N-dimethylformamide) increases expression ISO Gclc (Rattus norvegicus) 6480464 Diamide results in increased expression of GCLC mRNA and Diamide results in increased expression of GCLC protein CTD PMID:15115889 GCLC Human 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects expression ISO Gclc (Rattus norvegicus) 6480464 o and p'-DDT affects the expression of GCLC mRNA CTD PMID:17984292 GCLC Human 1,2-dichloroethane multiple interactions ISO Gclc (Mus musculus) 6480464 [ethylene dichloride co-treated with Ethanol] results in increased expression of GCLC mRNA more ... CTD PMID:30664321 and PMID:37150348 GCLC Human 1,2-dichloroethane increases expression ISO Gclc (Mus musculus) 6480464 ethylene dichloride results in increased expression of GCLC protein CTD PMID:37150348 GCLC Human 1,2-dimethylhydrazine decreases expression ISO Gclc (Mus musculus) 6480464 1 and 2-Dimethylhydrazine results in decreased expression of GCLC mRNA CTD PMID:22206623 GCLC Human 1,2-dimethylhydrazine multiple interactions ISO Gclc (Mus musculus) 6480464 [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of GCLC mRNA CTD PMID:22206623 GCLC Human 1,3-benzothiazole-2-thiol increases expression EXP 6480464 captax results in increased expression of GCLC mRNA CTD PMID:20491607 GCLC Human 1,3-dichloropropan-2-ol increases expression ISO Gclc (Rattus norvegicus) 6480464 1 and 3-dichloro-2-propanol results in increased expression of GCLC mRNA CTD PMID:26143167 GCLC Human 1-bromopropane multiple interactions ISO Gclc (Mus musculus) 6480464 NFE2L2 promotes the reaction [1-bromopropane results in increased expression of GCLC mRNA] CTD PMID:20211940 GCLC Human 1-bromopropane increases expression ISO Gclc (Mus musculus) 6480464 1-bromopropane results in increased expression of GCLC mRNA CTD PMID:20211940 GCLC Human 1-chloro-2,4-dinitrobenzene increases expression EXP 6480464 Dinitrochlorobenzene results in increased expression of GCLC mRNA CTD PMID:20146380 and PMID:20566472 GCLC Human 1-fluoro-2,4-dinitrobenzene increases expression EXP 6480464 Dinitrofluorobenzene results in increased expression of GCLC mRNA CTD PMID:23999411 GCLC Human 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expression ISO Gclc (Mus musculus) 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 GCLC Human 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions ISO Gclc (Mus musculus) 6480464 [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 GCLC Human 1-naphthyl isothiocyanate increases expression ISO Gclc (Rattus norvegicus) 6480464 1-Naphthylisothiocyanate results in increased expression of GCLC mRNA CTD PMID:20551477 GCLC Human 1-naphthyl isothiocyanate decreases expression ISO Gclc (Mus musculus) 6480464 1-Naphthylisothiocyanate results in decreased expression of GCLC mRNA CTD PMID:37348807 GCLC Human 1-naphthyl isothiocyanate multiple interactions ISO Gclc (Mus musculus) 6480464 [tectorigenin co-treated with 1-Naphthylisothiocyanate] results in increased expression of GCLC protein and tectorigenin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of GCLC mRNA] CTD PMID:37348807 GCLC Human 15-deoxy-Delta(12,14)-prostaglandin J2 multiple interactions EXP 6480464 15-deoxy-delta(12 more ... CTD PMID:21728338 GCLC Human 15-deoxy-Delta(12,14)-prostaglandin J2 increases expression EXP 6480464 15-deoxy-delta(12 more ... CTD PMID:21728338 GCLC Human 17alpha-ethynylestradiol affects expression EXP 6480464 Ethinyl Estradiol affects the expression of GCLC mRNA CTD PMID:20170705 and PMID:26865667 GCLC Human 17beta-estradiol multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [bisphenol A co-treated with Estradiol] results in increased expression of GCLC mRNA CTD PMID:26496021 GCLC Human 17beta-estradiol multiple interactions EXP 6480464 [Estradiol co-treated with TGFB1 protein] results in decreased expression of GCLC mRNA CTD PMID:30165855 GCLC Human 17beta-estradiol increases expression ISO Gclc (Rattus norvegicus) 6480464 Estradiol results in increased expression of GCLC mRNA and Estradiol results in increased expression of GCLC protein CTD PMID:31119341 and PMID:32145629 GCLC Human 1H-pyrazole increases expression ISO Gclc (Mus musculus) 6480464 pyrazole results in increased expression of GCLC mRNA CTD PMID:17945193 GCLC Human 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone multiple interactions ISO Gclc (Mus musculus) 6480464 Acetylcysteine inhibits the reaction [2' more ... CTD PMID:31029725 GCLC Human 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone increases expression ISO Gclc (Mus musculus) 6480464 2' more ... CTD PMID:31029725 GCLC Human 2,2',4,4'-Tetrabromodiphenyl ether increases expression EXP 6480464 2 more ... CTD PMID:25659769 GCLC Human 2,2',4,4'-Tetrabromodiphenyl ether multiple interactions EXP 6480464 [Eicosapentaenoic Acid analog co-treated with Docosahexaenoic Acids analog] promotes the reaction [2 more ... CTD PMID:25659769 GCLC Human 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Gclc (Mus musculus) 6480464 [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of GCLC mRNA more ... CTD PMID:16054899 more ... GCLC Human 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] results in increased expression of GCLC mRNA CTD PMID:29704546 GCLC Human 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Gclc (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of GCLC mRNA CTD PMID:20702594 more ... GCLC Human 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Gclc (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased expression of GCLC mRNA CTD PMID:15328365 more ... GCLC Human 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Gclc (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of GCLC mRNA CTD PMID:21215274 more ... GCLC Human 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of GCLC mRNA CTD PMID:19542225 and PMID:21802500 GCLC Human 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Gclc (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in increased expression of GCLC mRNA CTD PMID:16960034 GCLC Human 2,3,7,8-Tetrachlorodibenzofuran affects expression ISO Gclc (Mus musculus) 6480464 2 more ... CTD PMID:20702594 GCLC Human 2,4,6-trinitrobenzenesulfonic acid multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [Trinitrobenzenesulfonic Acid co-treated with Ethanol] results in increased expression of GCLC mRNA CTD PMID:10830784 GCLC Human 2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expression ISO Gclc (Mus musculus) 6480464 2 more ... CTD PMID:38648751 GCLC Human 2,4-dinitrotoluene affects expression ISO Gclc (Rattus norvegicus) 6480464 2 and 4-dinitrotoluene affects the expression of GCLC mRNA CTD PMID:21346803 GCLC Human 2,6-di-tert-butyl-4-methylphenol increases expression ISO Gclc (Mus musculus) 6480464 Butylated Hydroxytoluene results in increased expression of GCLC protein CTD PMID:21536018 GCLC Human 2,6-dinitrotoluene affects expression ISO Gclc (Rattus norvegicus) 6480464 2 and 6-dinitrotoluene affects the expression of GCLC mRNA CTD PMID:21346803 GCLC Human 2-(chloromethyl)pyridine increases expression EXP 6480464 2-chloromethylpyridine results in increased expression of GCLC mRNA CTD PMID:26198647 GCLC Human 2-acetamidofluorene increases expression EXP 6480464 2-Acetylaminofluorene results in increased expression of GCLC mRNA CTD PMID:16426233 GCLC Human 2-acetamidofluorene multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GCLC mRNA and [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GCLC mRNA CTD PMID:14656948 and PMID:16158176 GCLC Human 2-acetamidofluorene increases expression ISO Gclc (Mus musculus) 6480464 2-Acetylaminofluorene results in increased expression of GCLC mRNA CTD PMID:16426233 GCLC Human 2-amino-2-deoxy-D-galactopyranose multiple interactions ISO Gclc (Mus musculus) 6480464 8-oxoberberine promotes the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of GCLC mRNA] more ... CTD PMID:35691465 GCLC Human 2-amino-2-deoxy-D-glucopyranose increases expression ISO Gclc (Mus musculus) 6480464 Glucosamine analog results in increased expression of GCLC mRNA CTD PMID:21825963 GCLC Human 2-butoxyethanol increases expression ISO Gclc (Mus musculus) 6480464 n-butoxyethanol results in increased expression of GCLC mRNA CTD PMID:19812364 GCLC Human 2-chloroethanol multiple interactions ISO Gclc (Rattus norvegicus) 6480464 allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of GCLC mRNA] more ... CTD PMID:31585129 GCLC Human 2-chloroethanol increases expression ISO Gclc (Rattus norvegicus) 6480464 Ethylene Chlorohydrin results in increased expression of GCLC mRNA and Ethylene Chlorohydrin results in increased expression of GCLC protein CTD PMID:31585129 GCLC Human 2-hydroxyethyl methacrylate increases expression EXP 6480464 hydroxyethyl methacrylate results in increased expression of GCLC mRNA and hydroxyethyl methacrylate results in increased expression of GCLC protein CTD PMID:30497689 GCLC Human 2-hydroxypropanoic acid increases expression EXP 6480464 Lactic Acid results in increased expression of GCLC mRNA CTD PMID:20566472 GCLC Human 2-nitrofluorene increases expression ISO Gclc (Rattus norvegicus) 6480464 2-nitrofluorene results in increased expression of GCLC mRNA CTD PMID:14600272 and PMID:15890375 GCLC Human 2-tert-butylhydroquinone multiple interactions ISO Gclc (Mus musculus) 6480464 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of GCLC mRNA] more ... CTD PMID:19328227 more ... GCLC Human 2-tert-butylhydroquinone decreases expression EXP 6480464 2-tert-butylhydroquinone results in decreased expression of GCLC mRNA CTD PMID:35724838 GCLC Human 2-tert-butylhydroquinone increases expression EXP 6480464 2-tert-butylhydroquinone results in increased expression of GCLC mRNA CTD PMID:27178040 and PMID:30806763 GCLC Human 2-tert-butylhydroquinone increases expression ISO Gclc (Rattus norvegicus) 6480464 2-tert-butylhydroquinone results in increased expression of GCLC mRNA CTD PMID:10978506 GCLC Human 2-tert-butylhydroquinone increases activity ISO Gclc (Mus musculus) 6480464 2-tert-butylhydroquinone results in increased activity of GCLC protein CTD PMID:7955076 GCLC Human 2-tert-butylhydroquinone affects expression EXP 6480464 2-tert-butylhydroquinone affects the expression of GCLC mRNA CTD PMID:15946948 GCLC Human 2-tert-butylhydroquinone increases expression ISO Gclc (Mus musculus) 6480464 2-tert-butylhydroquinone results in increased expression of GCLC mRNA CTD PMID:12007577 more ... GCLC Human 3,3',4,4',5-pentachlorobiphenyl increases expression ISO Gclc (Rattus norvegicus) 6480464 3 more ... CTD PMID:23196670 GCLC Human 3,3',4,4',5-pentachlorobiphenyl increases expression ISO Gclc (Mus musculus) 6480464 3 more ... CTD PMID:23994337 GCLC Human 3,3',5,5'-tetrabromobisphenol A increases expression EXP 6480464 tetrabromobisphenol A results in increased expression of GCLC mRNA CTD PMID:30951941 GCLC Human 3,3',5,5'-tetrabromobisphenol A multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [tetrabromobisphenol A results in increased expression of GCLC mRNA] CTD PMID:30951941 GCLC Human 3,4-methylenedioxymethamphetamine multiple interactions ISO Gclc (Rattus norvegicus) 6480464 N-Methyl-3 and 4-methylenedioxyamphetamine inhibits the reaction [sulforaphane results in increased expression of GCLC mRNA] CTD PMID:21871945 GCLC Human 3-chloropropane-1,2-diol decreases expression ISO Gclc (Rattus norvegicus) 6480464 alpha-Chlorohydrin results in decreased expression of GCLC mRNA CTD PMID:28522335 GCLC Human 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO Gclc (Mus musculus) 6480464 [Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of GCLC mRNA more ... CTD PMID:16054899 and PMID:33412187 GCLC Human 3-nitropropanoic acid multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [naringin co-treated with 3-nitropropionic acid] results in increased expression of GCLC mRNA CTD PMID:22871521 GCLC Human 3-O-Caffeoyl-1-O-methylquinic acid multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of GCLC mRNA] CTD PMID:16631525 GCLC Human 3-O-Caffeoyl-1-O-methylquinic acid increases expression EXP 6480464 3-O-caffeoyl-1-methylquinic acid results in increased expression of GCLC mRNA CTD PMID:16631525 GCLC Human 3-phenylprop-2-enal multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [cinnamaldehyde results in increased expression of GCLC protein] more ... CTD PMID:20351055 and PMID:21469739 GCLC Human 3-phenylprop-2-enal increases expression EXP 6480464 cinnamaldehyde results in increased expression of GCLC mRNA and cinnamaldehyde results in increased expression of GCLC protein CTD PMID:17178418 more ... GCLC Human 3H-1,2-dithiole-3-thione increases expression ISO Gclc (Mus musculus) 6480464 1 more ... CTD PMID:18367636 and PMID:22959925 GCLC Human 3H-1,2-dithiole-3-thione increases expression EXP 6480464 1 and 2-dithiol-3-thione results in increased expression of GCLC mRNA CTD PMID:19073213 and PMID:19408115 GCLC Human 3H-1,2-dithiole-3-thione multiple interactions ISO Gclc (Mus musculus) 6480464 [1 more ... CTD PMID:18367636 and PMID:22495766 GCLC Human 3H-1,2-dithiole-3-thione increases expression ISO Gclc (Rattus norvegicus) 6480464 1 and 2-dithiol-3-thione results in increased expression of GCLC mRNA CTD PMID:15946642 GCLC Human 3H-1,2-dithiole-3-thione increases activity ISO Gclc (Rattus norvegicus) 6480464 1 and 2-dithiol-3-thione results in increased activity of GCLC protein CTD PMID:12535742 GCLC Human 3H-1,2-dithiole-3-thione multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [1 and 2-dithiol-3-thione results in increased activity of GCLC protein] which results in decreased susceptibility to Acrolein CTD PMID:12535742 GCLC Human 4,4'-methylene-bis-(2-chloroaniline) increases expression EXP 6480464 Methylenebis(chloroaniline) results in increased expression of GCLC mRNA CTD PMID:26198647 GCLC Human 4,4'-sulfonyldiphenol increases expression ISO Gclc (Mus musculus) 6480464 bisphenol S results in increased expression of GCLC mRNA CTD PMID:33297965 GCLC Human 4,4'-sulfonyldiphenol multiple interactions EXP 6480464 [bisphenol S co-treated with cylindrospermopsin] results in increased expression of GCLC mRNA CTD PMID:32244372 GCLC Human 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases expression ISO Gclc (Rattus norvegicus) 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of GCLC mRNA CTD PMID:15890375 GCLC Human 4-amino-2,6-dinitrotoluene affects expression ISO Gclc (Rattus norvegicus) 6480464 4-amino-2 and 6-dinitrotoluene affects the expression of GCLC mRNA CTD PMID:21346803 GCLC Human 4-hydroxy-TEMPO multiple interactions EXP 6480464 NFE2L2 protein affects the reaction [tempol inhibits the reaction [lipopolysaccharide more ... CTD PMID:38454815 GCLC Human 4-hydroxy-TEMPO multiple interactions ISO Gclc (Rattus norvegicus) 6480464 tempol inhibits the reaction [Aldosterone results in increased expression of GCLC protein] CTD PMID:24512358 and PMID:25204689 GCLC Human 4-hydroxynon-2-enal increases expression ISO Gclc (Mus musculus) 6480464 4-hydroxy-2-nonenal results in increased expression of GCLC mRNA CTD PMID:19191707 GCLC Human 4-hydroxynon-2-enal multiple interactions ISO Gclc (Rattus norvegicus) 6480464 NFE2L2 mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of GCLC mRNA] CTD PMID:24291486 GCLC Human 4-hydroxynon-2-enal increases expression ISO Gclc (Rattus norvegicus) 6480464 4-hydroxy-2-nonenal results in increased expression of GCLC protein CTD PMID:24291486 GCLC Human 4-hydroxyphenyl retinamide increases expression ISO Gclc (Mus musculus) 6480464 Fenretinide results in increased expression of GCLC mRNA CTD PMID:28973697 GCLC Human 4-hydroxyphenyl retinamide increases expression EXP 6480464 Fenretinide results in increased expression of GCLC mRNA CTD PMID:21319187 GCLC Human 4-hydroxyphenyl retinamide multiple interactions EXP 6480464 [Fenretinide co-treated with scriptaid] results in increased expression of GCLC mRNA and [Fenretinide co-treated with trichostatin A] results in increased expression of GCLC mRNA CTD PMID:21319187 GCLC Human 4-nitro-1,2-phenylenediamine increases expression EXP 6480464 1 and 2-diamino-4-nitrobenzene results in increased expression of GCLC mRNA CTD PMID:26198647 GCLC Human 4-phenyl-3-furoxancarbonitrile increases expression EXP 6480464 4-phenyl-3-furoxancarbonitrile results in increased expression of GCLC mRNA CTD PMID:22851183 GCLC Human 4-phenyl-3-furoxancarbonitrile increases expression ISO Gclc (Mus musculus) 6480464 4-phenyl-3-furoxancarbonitrile analog results in increased expression of GCLC mRNA CTD PMID:22851183 GCLC Human 5-(hydroxymethyl)cytosine multiple interactions EXP 6480464 [hydroquinone affects the methylation of GCLC promoter] which results in increased abundance of 5-hydroxymethylcytosine CTD PMID:23940045 GCLC Human 5-bromo-2'-deoxyuridine multiple interactions ISO Gclc (Mus musculus) 6480464 [Bromodeoxyuridine co-treated with furan] results in increased expression of GCLC mRNA CTD PMID:24910943 GCLC Human 5-methylcytosine multiple interactions EXP 6480464 [hydroquinone affects the methylation of GCLC promoter] which results in decreased abundance of 5-Methylcytosine CTD PMID:23940045 GCLC Human 6-propyl-2-thiouracil increases expression ISO Gclc (Rattus norvegicus) 6480464 Propylthiouracil results in increased expression of GCLC mRNA CTD PMID:30047161 GCLC Human 7,8-dihydroxycoumarin increases expression EXP 6480464 daphnetin results in increased expression of GCLC protein CTD PMID:30738023 GCLC Human [6]-Shogaol increases expression ISO Gclc (Mus musculus) 6480464 shogaol results in increased expression of GCLC mRNA CTD PMID:25148906 GCLC Human [6]-Shogaol increases expression EXP 6480464 shogaol metabolite results in increased expression of GCLC protein and shogaol results in increased expression of GCLC protein CTD PMID:25148906 GCLC Human [6]-Shogaol multiple interactions ISO Gclc (Mus musculus) 6480464 NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of GCLC mRNA] CTD PMID:25148906 GCLC Human acetaldehyde increases expression ISO Gclc (Rattus norvegicus) 6480464 Acetaldehyde results in increased expression of GCLC mRNA CTD PMID:11439094 GCLC Human acetic acid increases expression EXP 6480464 Acetic Acid results in increased expression of GCLC mRNA CTD PMID:35750087 GCLC Human acetylcholine decreases response to substance EXP 6480464 GCLC promoter SNP results in decreased susceptibility to Acetylcholine CTD PMID:12598062 GCLC Human acrolein increases expression ISO Gclc (Rattus norvegicus) 6480464 Acrolein results in increased expression of GCLC mRNA CTD PMID:25145656 and PMID:38090360 GCLC Human acrolein multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [1 and 2-dithiol-3-thione results in increased activity of GCLC protein] which results in decreased susceptibility to Acrolein CTD PMID:12535742 GCLC Human acrolein increases expression EXP 6480464 Acrolein results in increased expression of GCLC mRNA CTD PMID:12084617 and PMID:28109747 GCLC Human acrylamide increases expression EXP 6480464 Acrylamide results in increased expression of GCLC mRNA CTD PMID:32763439 GCLC Human acrylamide increases expression ISO Gclc (Mus musculus) 6480464 Acrylamide results in increased expression of GCLC mRNA CTD PMID:37540211 GCLC Human acrylamide multiple interactions ISO Gclc (Mus musculus) 6480464 IL1B gene mutant form inhibits the reaction [Acrylamide results in increased expression of GCLC mRNA] CTD PMID:37540211 GCLC Human actinomycin D multiple interactions EXP 6480464 [Dactinomycin co-treated with nutlin 3] results in increased secretion of GCLC protein and Dactinomycin inhibits the reaction [Vitamin K 3 results in increased expression of GCLC mRNA] CTD PMID:11972604 and PMID:38460933 GCLC Human actinomycin D multiple interactions ISO Gclc (Rattus norvegicus) 6480464 Dactinomycin inhibits the reaction [notoginsenoside R1 results in increased expression of GCLC protein] CTD PMID:24437944 GCLC Human Aescin increases expression ISO Gclc (Mus musculus) 6480464 Escin results in increased expression of GCLC protein CTD PMID:36905866 GCLC Human Aescin increases expression EXP 6480464 Escin results in increased expression of GCLC protein CTD PMID:36905866 GCLC Human Aescin multiple interactions EXP 6480464 Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of GCLC protein] CTD PMID:36905866 GCLC Human Aescin multiple interactions ISO Gclc (Mus musculus) 6480464 Escin inhibits the reaction [Dietary Fats results in decreased expression of GCLC protein] more ... CTD PMID:36905866 GCLC Human aflatoxin B1 increases expression ISO Gclc (Mus musculus) 6480464 Aflatoxin B1 results in increased expression of GCLC mRNA CTD PMID:19770486 GCLC Human aflatoxin B1 multiple interactions ISO Gclc (Mus musculus) 6480464 Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of GCLC mRNA] CTD PMID:35063475 GCLC Human aflatoxin B1 decreases expression ISO Gclc (Mus musculus) 6480464 Aflatoxin B1 results in decreased expression of GCLC mRNA CTD PMID:35063475 GCLC Human aflatoxin B1 decreases methylation EXP 6480464 Aflatoxin B1 results in decreased methylation of GCLC gene CTD PMID:27153756 GCLC Human aflatoxin B1 increases expression ISO Gclc (Rattus norvegicus) 6480464 Aflatoxin B1 results in increased expression of GCLC mRNA CTD PMID:15890375 more ... GCLC Human alachlor increases expression ISO Gclc (Rattus norvegicus) 6480464 alachlor results in increased expression of GCLC protein CTD PMID:14563481 GCLC Human alcohol decreases expression ISO Gclc (Mus musculus) 6480464 Alcohols results in decreased expression of GCLC mRNA CTD PMID:18814483 GCLC Human alcohol multiple interactions ISO Gclc (Mus musculus) 6480464 Vitamin E inhibits the reaction [Alcohols results in increased expression of GCLC mRNA] CTD PMID:18814483 GCLC Human aldehydo-D-glucosamine increases expression ISO Gclc (Mus musculus) 6480464 Glucosamine analog results in increased expression of GCLC mRNA CTD PMID:21825963 GCLC Human aldehydo-D-glucose multiple interactions ISO Gclc (Mus musculus) 6480464 [Glucose co-treated with gastrodin] affects the expression of GCLC mRNA CTD PMID:33764184 GCLC Human aldehydo-D-glucose multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [Glucose co-treated with gastrodin] affects the expression of GCLC mRNA CTD PMID:33764184 GCLC Human aldosterone multiple interactions ISO Gclc (Rattus norvegicus) 6480464 Spironolactone inhibits the reaction [Aldosterone results in increased expression of GCLC protein] and tempol inhibits the reaction [Aldosterone results in increased expression of GCLC protein] CTD PMID:24512358 and PMID:25204689 GCLC Human aldosterone increases expression ISO Gclc (Rattus norvegicus) 6480464 Aldosterone results in increased expression of GCLC protein CTD PMID:24512358 and PMID:25204689 GCLC Human all-trans-retinal increases expression EXP 6480464 Retinaldehyde results in increased expression of GCLC mRNA CTD PMID:25331497 and PMID:27751755 GCLC Human all-trans-retinoic acid decreases expression ISO Gclc (Rattus norvegicus) 6480464 Tretinoin results in decreased expression of GCLC mRNA and Tretinoin results in decreased expression of GCLC protein CTD PMID:30267739 GCLC Human all-trans-retinoic acid decreases expression EXP 6480464 Tretinoin results in decreased expression of GCLC mRNA CTD PMID:33167477 GCLC Human all-trans-retinoic acid multiple interactions EXP 6480464 alpha-pyrrolidinononanophenone analog promotes the reaction [Tretinoin results in increased expression of GCLC mRNA] CTD PMID:38040126 GCLC Human all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of GCLC mRNA CTD PMID:38040126 GCLC Human allethrin multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of GCLC protein CTD PMID:34896426 GCLC Human alloxan multiple interactions ISO Gclc (Rattus norvegicus) 6480464 ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of GCLC mRNA] more ... CTD PMID:33359794 GCLC Human alloxan decreases expression ISO Gclc (Rattus norvegicus) 6480464 Alloxan results in decreased expression of GCLC mRNA and Alloxan results in decreased expression of GCLC protein CTD PMID:33359794 GCLC Human allyl isothiocyanate increases activity ISO Gclc (Mus musculus) 6480464 allyl isothiocyanate results in increased activity of GCLC protein CTD PMID:24036144 GCLC Human allyl isothiocyanate increases expression ISO Gclc (Mus musculus) 6480464 allyl isothiocyanate results in increased expression of GCLC mRNA CTD PMID:24036144 GCLC Human allyl isothiocyanate multiple interactions ISO Gclc (Mus musculus) 6480464 NFE2L2 protein affects the reaction [allyl isothiocyanate results in increased expression of GCLC mRNA] CTD PMID:24036144 GCLC Human allyl methyl disulfide multiple interactions ISO Gclc (Mus musculus) 6480464 allyl methyl disulfide inhibits the reaction [Dimethylformamide results in increased expression of GCLC protein] CTD PMID:37995826 GCLC Human alpha,alpha-trehalose multiple interactions ISO Gclc (Rattus norvegicus) 6480464 Trehalose inhibits the reaction [cadmium acetate results in increased expression of GCLC protein] CTD PMID:29140578 GCLC Human alpha-D-galactose multiple interactions ISO Gclc (Rattus norvegicus) 6480464 Saponins inhibits the reaction [Galactose results in decreased expression of GCLC mRNA] CTD PMID:25892055 GCLC Human alpha-D-galactose decreases expression ISO Gclc (Rattus norvegicus) 6480464 Galactose results in decreased expression of GCLC mRNA CTD PMID:25892055 GCLC Human alpha-hexylcinnamaldehyde increases expression EXP 6480464 hexyl cinnamic aldehyde results in increased expression of GCLC mRNA CTD PMID:20566472 GCLC Human alpha-linolenic acid increases activity EXP 6480464 alpha-Linolenic Acid results in increased activity of GCLC protein CTD PMID:17092368 GCLC Human alpha-linolenic acid increases expression EXP 6480464 alpha-Linolenic Acid results in increased expression of GCLC mRNA CTD PMID:17092368 GCLC Human alpha-Solamarine multiple interactions ISO Gclc (Mus musculus) 6480464 alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of GCLC protein] CTD PMID:35350913 GCLC Human Altertoxin II affects expression EXP 6480464 altertoxin II affects the expression of GCLC mRNA CTD PMID:27178040 GCLC Human amitrole increases expression ISO Gclc (Rattus norvegicus) 6480464 Amitrole results in increased expression of GCLC mRNA CTD PMID:30047161 GCLC Human amlexanox multiple interactions ISO Gclc (Mus musculus) 6480464 [Acetaminophen co-treated with amlexanox co-treated with dorsomorphin] affects the expression of GCLC mRNA and [Acetaminophen co-treated with amlexanox] affects the expression of GCLC mRNA CTD PMID:31697998 GCLC Human amlexanox increases expression ISO Gclc (Mus musculus) 6480464 amlexanox results in increased expression of GCLC mRNA CTD PMID:31697998 GCLC Human ampicillin decreases expression EXP 6480464 Ampicillin results in decreased expression of GCLC mRNA CTD PMID:21632981 and PMID:26198647 GCLC Human andrographolide increases expression ISO Gclc (Rattus norvegicus) 6480464 andrographolide results in increased expression of GCLC mRNA and andrographolide results in increased expression of GCLC protein CTD PMID:25110055 and PMID:29355602 GCLC Human andrographolide decreases expression EXP 6480464 andrographolide results in decreased expression of GCLC mRNA CTD PMID:35724838 GCLC Human andrographolide multiple interactions EXP 6480464 [andrographolide co-treated with TNF protein] results in increased expression of GCLC mRNA CTD PMID:35724838 GCLC Human andrographolide multiple interactions ISO Gclc (Mus musculus) 6480464 andrographolide inhibits the reaction [Acetaminophen results in decreased expression of GCLC mRNA] CTD PMID:29355602 GCLC Human andrographolide increases expression EXP 6480464 andrographolide results in increased expression of GCLC protein CTD PMID:29355602 GCLC Human anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions EXP 6480464 pyrazolanthrone inhibits the reaction [[clivorine co-treated with Quercetin] results in increased expression of GCLC mRNA] more ... CTD PMID:21469739 and PMID:25881548 GCLC Human anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO Gclc (Mus musculus) 6480464 pyrazolanthrone inhibits the reaction [Ozone results in increased expression of GCLC mRNA] and pyrazolanthrone promotes the reaction [arsenite results in increased expression of GCLC mRNA] CTD PMID:17460151 and PMID:19328227 GCLC Human antimonite multiple interactions EXP 6480464 [Antimony Potassium Tartrate results in increased abundance of antimonite] which results in increased expression of GCLC mRNA CTD PMID:32076005 GCLC Human antimony(0) multiple interactions EXP 6480464 GCLC protein inhibits the reaction [ABCC1 protein results in decreased susceptibility to Antimony] CTD PMID:11560771 GCLC Human apigenin increases expression ISO Gclc (Rattus norvegicus) 6480464 Apigenin results in increased expression of GCLC mRNA and Apigenin results in increased expression of GCLC protein CTD PMID:22864849 GCLC Human apigenin multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [Apigenin results in increased expression of GCLC mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide CTD PMID:22864849 GCLC Human apigenin increases expression EXP 6480464 Apigenin results in increased expression of GCLC mRNA CTD PMID:11864778 GCLC Human arachidonic acid increases activity EXP 6480464 Arachidonic Acid results in increased activity of GCLC protein CTD PMID:17092368 GCLC Human arachidonic acid increases expression EXP 6480464 Arachidonic Acid results in increased expression of GCLC mRNA CTD PMID:16704987 and PMID:17092368 GCLC Human Aroclor 1254 decreases expression ISO Gclc (Mus musculus) 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of GCLC mRNA CTD PMID:23650126 GCLC Human arotinoid acid multiple interactions EXP 6480464 [4-(2-(5 more ... CTD PMID:34480604 GCLC Human arsane increases expression EXP 6480464 Arsenic results in increased expression of GCLC mRNA and Arsenic results in increased expression of GCLC protein CTD PMID:18487201 more ... GCLC Human arsane multiple interactions EXP 6480464 [Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of GCLC mRNA more ... CTD PMID:29751399 more ... GCLC Human arsane affects response to substance EXP 6480464 GCLC gene SNP affects the susceptibility to Arsenic CTD PMID:29751399 GCLC Human arsane increases expression ISO Gclc (Mus musculus) 6480464 Arsenic results in increased expression of GCLC mRNA and Arsenic results in increased expression of GCLC protein CTD PMID:23000044 and PMID:35523338 GCLC Human arsane multiple interactions ISO Gclc (Mus musculus) 6480464 NFE2L2 mRNA affects the reaction [Arsenic results in increased expression of GCLC mRNA] and NFE2L2 protein affects the reaction [Arsenic results in increased expression of GCLC protein] CTD PMID:23000044 and PMID:35523338 GCLC Human arsenic atom increases expression EXP 6480464 Arsenic results in increased expression of GCLC mRNA and Arsenic results in increased expression of GCLC protein CTD PMID:18487201 more ... GCLC Human arsenic atom affects response to substance EXP 6480464 GCLC gene SNP affects the susceptibility to Arsenic CTD PMID:29751399 GCLC Human arsenic atom multiple interactions EXP 6480464 [Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of GCLC mRNA more ... CTD PMID:29751399 more ... GCLC Human arsenic atom increases expression ISO Gclc (Mus musculus) 6480464 Arsenic results in increased expression of GCLC mRNA and Arsenic results in increased expression of GCLC protein CTD PMID:23000044 and PMID:35523338 GCLC Human arsenic atom multiple interactions ISO Gclc (Mus musculus) 6480464 NFE2L2 mRNA affects the reaction [Arsenic results in increased expression of GCLC mRNA] and NFE2L2 protein affects the reaction [Arsenic results in increased expression of GCLC protein] CTD PMID:23000044 and PMID:35523338 GCLC Human arsenite(3-) multiple interactions ISO Gclc (Mus musculus) 6480464 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [arsenite results in increased expression of GCLC mRNA] more ... CTD PMID:15894712 more ... GCLC Human arsenite(3-) multiple interactions EXP 6480464 [arsenite co-treated with epigallocatechin gallate] results in increased expression of GCLC protein more ... CTD PMID:22476201 more ... GCLC Human arsenite(3-) increases expression EXP 6480464 arsenite results in increased expression of GCLC mRNA and arsenite results in increased expression of GCLC protein CTD PMID:22476201 GCLC Human arsenite(3-) increases expression ISO Gclc (Mus musculus) 6480464 arsenite results in increased expression of GCLC mRNA and arsenite results in increased expression of GCLC protein CTD PMID:15894712 more ... GCLC Human arsenous acid multiple interactions EXP 6480464 [Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of GCLC mRNA and [Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of GCLC protein CTD PMID:33434570 GCLC Human arsenous acid decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of GCLC protein CTD PMID:25341331 and PMID:25419056 GCLC Human arsenous acid increases expression ISO Gclc (Mus musculus) 6480464 Arsenic Trioxide results in increased expression of GCLC mRNA CTD PMID:29049341 GCLC Human arsenous acid increases expression EXP 6480464 Arsenic Trioxide results in increased expression of GCLC mRNA and Arsenic Trioxide results in increased expression of GCLC protein CTD PMID:19417148 more ... GCLC Human arsenous acid decreases response to substance EXP 6480464 GCLC protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:20707922 and PMID:29549912 GCLC Human arsenous acid multiple interactions ISO Gclc (Mus musculus) 6480464 NFE2L2 protein affects the reaction [Arsenic Trioxide results in increased expression of GCLC mRNA] CTD PMID:29049341 GCLC Human artesunate decreases response to substance EXP 6480464 GCLC mRNA results in decreased susceptibility to artesunate CTD PMID:15796179 GCLC Human artesunate affects response to substance EXP 6480464 GCLC mRNA affects the susceptibility to artesunate CTD PMID:15796179 GCLC Human astilbin multiple interactions EXP 6480464 astilbin inhibits the reaction [Cisplatin results in decreased expression of GCLC mRNA] CTD PMID:29471006 GCLC Human atrazine multiple interactions ISO Gclc (Mus musculus) 6480464 Lycopene inhibits the reaction [Atrazine results in increased expression of GCLC mRNA] CTD PMID:36216167 GCLC Human atrazine increases expression ISO Gclc (Mus musculus) 6480464 Atrazine results in increased expression of GCLC mRNA CTD PMID:36216167 GCLC Human Augmentin increases expression EXP 6480464 Amoxicillin-Potassium Clavulanate Combination results in increased expression of GCLC mRNA CTD PMID:34767876 GCLC Human azathioprine increases expression EXP 6480464 Azathioprine results in increased expression of GCLC mRNA CTD PMID:22623647 and PMID:26198647 GCLC Human Bandrowski's base increases expression EXP 6480464 Bandrowski's base results in increased expression of GCLC mRNA CTD PMID:20566472 GCLC Human Bardoxolone methyl increases expression EXP 6480464 bardoxolone methyl results in increased expression of GCLC mRNA and bardoxolone methyl results in increased expression of GCLC protein CTD PMID:27480280 and PMID:34480604 GCLC Human Bardoxolone methyl decreases expression EXP 6480464 bardoxolone methyl results in decreased expression of GCLC mRNA CTD PMID:35724838 GCLC Human bellidifolin increases expression ISO Gclc (Rattus norvegicus) 6480464 bellidifolin results in increased expression of GCLC mRNA and bellidifolin results in increased expression of GCLC protein CTD PMID:30800665 GCLC Human benzalkonium chloride increases expression EXP 6480464 Benzalkonium Compounds results in increased expression of GCLC mRNA CTD PMID:30806763 GCLC Human benzene affects expression ISO Gclc (Rattus norvegicus) 6480464 Benzene affects the expression of GCLC mRNA CTD PMID:15878777 GCLC Human benzene multiple interactions ISO Gclc (Mus musculus) 6480464 Deferoxamine inhibits the reaction [Benzene results in decreased expression of GCLC mRNA] and ferrostatin-1 inhibits the reaction [Benzene results in decreased expression of GCLC mRNA] CTD PMID:35661779 GCLC Human benzene decreases expression ISO Gclc (Mus musculus) 6480464 Benzene results in decreased expression of GCLC mRNA CTD PMID:35661779 GCLC Human benzidine increases expression EXP 6480464 benzidine results in increased expression of GCLC mRNA CTD PMID:26198647 GCLC Human benzo[a]pyrene multiple interactions EXP 6480464 [Cadmium Chloride co-treated with Benzo(a)pyrene] results in increased expression of GCLC mRNA CTD PMID:25170436 GCLC Human benzo[a]pyrene increases methylation EXP 6480464 Benzo(a)pyrene results in increased methylation of GCLC promoter CTD PMID:27901495 GCLC Human benzo[a]pyrene decreases methylation EXP 6480464 Benzo(a)pyrene results in decreased methylation of GCLC 3' UTR CTD PMID:27901495 GCLC Human benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of GCLC mRNA CTD PMID:20106945 more ... GCLC Human benzo[a]pyrene increases expression ISO Gclc (Mus musculus) 6480464 Benzo(a)pyrene results in increased expression of GCLC mRNA CTD PMID:14625279 more ... GCLC Human benzo[a]pyrene multiple interactions ISO Gclc (Mus musculus) 6480464 [arsenite co-treated with Benzo(a)pyrene] results in increased expression of GCLC mRNA more ... CTD PMID:14625279 more ... GCLC Human benzo[a]pyrene diol epoxide I decreases expression EXP 6480464 7 more ... CTD PMID:19150397 GCLC Human benzoic acid increases expression EXP 6480464 Benzoic Acid results in increased expression of GCLC mRNA CTD PMID:20566472 GCLC Human benzoquinones increases expression ISO Gclc (Mus musculus) 6480464 Benzoquinones analog results in increased expression of GCLC protein CTD PMID:21651925 GCLC Human berberine multiple interactions ISO Gclc (Rattus norvegicus) 6480464 Berberine inhibits the reaction [Bortezomib results in increased expression of GCLC mRNA] CTD PMID:35121005 GCLC Human beta-D-glucosamine increases expression ISO Gclc (Mus musculus) 6480464 Glucosamine analog results in increased expression of GCLC mRNA CTD PMID:21825963 GCLC Human beta-naphthoflavone increases expression EXP 6480464 beta-Naphthoflavone results in increased expression of GCLC mRNA CTD PMID:16426233 GCLC Human beta-naphthoflavone increases expression ISO Gclc (Mus musculus) 6480464 beta-Naphthoflavone results in increased expression of GCLC mRNA CTD PMID:16426233 and PMID:23994337 GCLC Human bis(2-ethylhexyl) phthalate multiple interactions ISO Gclc (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in decreased expression of GCLC mRNA and Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of GCLC mRNA] CTD PMID:35917956 more ... GCLC Human bis(2-ethylhexyl) phthalate increases expression ISO Gclc (Mus musculus) 6480464 Diethylhexyl Phthalate results in increased expression of GCLC mRNA CTD PMID:35917956 more ... GCLC Human bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of GCLC mRNA CTD PMID:20170705 and PMID:30903817 GCLC Human bisphenol A multiple interactions ISO Gclc (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in decreased expression of GCLC mRNA CTD PMID:37364641 GCLC Human bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with cylindrospermopsin] results in increased expression of GCLC mRNA CTD PMID:32244372 GCLC Human bisphenol A decreases expression ISO Gclc (Mus musculus) 6480464 bisphenol A results in decreased expression of GCLC mRNA CTD PMID:30547568 and PMID:32156529 GCLC Human bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of GCLC and bisphenol A results in increased expression of GCLC protein CTD PMID:31207516 and PMID:34186270 GCLC Human bisphenol A increases expression ISO Gclc (Mus musculus) 6480464 bisphenol A results in increased expression of GCLC mRNA and bisphenol A results in increased expression of GCLC protein CTD PMID:28796629 GCLC Human bisphenol A increases expression ISO Gclc (Rattus norvegicus) 6480464 bisphenol A results in increased expression of GCLC mRNA CTD PMID:25181051 more ... GCLC Human bisphenol A multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [bisphenol A co-treated with Estradiol] results in increased expression of GCLC mRNA CTD PMID:26496021 GCLC Human Bisphenol B increases expression EXP 6480464 bisphenol B results in increased expression of GCLC protein CTD PMID:34186270 GCLC Human bisphenol F multiple interactions EXP 6480464 [bisphenol F co-treated with cylindrospermopsin] results in increased expression of GCLC mRNA CTD PMID:32244372 GCLC Human bisphenol F increases expression EXP 6480464 bisphenol F results in increased expression of GCLC protein CTD PMID:34186270 GCLC Human bleomycin A2 multiple interactions ISO Gclc (Mus musculus) 6480464 caffeic acid phenethyl ester inhibits the reaction [Bleomycin results in decreased expression of GCLC protein] CTD PMID:23570914 GCLC Human bleomycin A2 decreases expression ISO Gclc (Mus musculus) 6480464 Bleomycin results in decreased expression of GCLC protein CTD PMID:23570914 GCLC Human bleomycin A5 increases expression EXP 6480464 bleomycetin results in increased expression of GCLC mRNA CTD PMID:21040473 GCLC Human boric acid increases expression EXP 6480464 boric acid results in increased expression of GCLC mRNA CTD PMID:30196486 GCLC Human boric acid increases expression ISO Gclc (Mus musculus) 6480464 boric acid results in increased expression of GCLC mRNA CTD PMID:30196486 GCLC Human boric acid multiple interactions ISO Gclc (Mus musculus) 6480464 EIF2AK3 protein affects the reaction [boric acid results in increased expression of GCLC mRNA] CTD PMID:30196486 GCLC Human bortezomib multiple interactions ISO Gclc (Rattus norvegicus) 6480464 Berberine inhibits the reaction [Bortezomib results in increased expression of GCLC mRNA] CTD PMID:35121005 GCLC Human bortezomib increases expression ISO Gclc (Rattus norvegicus) 6480464 Bortezomib results in increased expression of GCLC mRNA CTD PMID:35121005 GCLC Human bosentan increases expression EXP 6480464 Bosentan results in increased expression of GCLC mRNA CTD PMID:29761207 GCLC Human Brodifacoum increases expression ISO Gclc (Rattus norvegicus) 6480464 bromfenacoum results in increased expression of GCLC protein CTD PMID:28903499 GCLC Human bromobenzene increases expression ISO Gclc (Mus musculus) 6480464 bromobenzene results in increased expression of GCLC protein CTD PMID:18078705 GCLC Human Bromochloroacetonitrile increases expression EXP 6480464 bromochloroacetonitrile results in increased expression of GCLC mRNA CTD PMID:35842135 GCLC Human Brusatol decreases expression EXP 6480464 brusatol results in decreased expression of GCLC protein CTD PMID:27639429 GCLC Human buspirone decreases expression ISO Gclc (Rattus norvegicus) 6480464 Buspirone results in decreased expression of GCLC mRNA CTD PMID:24136188 GCLC Human buta-1,3-diene affects expression ISO Gclc (Mus musculus) 6480464 1 and 3-butadiene affects the expression of GCLC mRNA CTD PMID:29038090 GCLC Human butanal decreases expression EXP 6480464 butyraldehyde results in decreased expression of GCLC mRNA CTD PMID:26079696 GCLC Human butane-2,3-dione increases expression ISO Gclc (Rattus norvegicus) 6480464 Diacetyl results in increased expression of GCLC mRNA CTD PMID:25145656 GCLC Human butylated hydroxyanisole increases expression EXP 6480464 Butylated Hydroxyanisole results in increased expression of GCLC mRNA CTD PMID:16426233 GCLC Human butylated hydroxyanisole increases expression ISO Gclc (Mus musculus) 6480464 Butylated Hydroxyanisole results in increased expression of GCLC mRNA and Butylated Hydroxyanisole results in increased expression of GCLC protein CTD PMID:16426233 and PMID:25922074 GCLC Human Butylbenzyl phthalate multiple interactions ISO Gclc (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in decreased expression of GCLC mRNA CTD PMID:37364641 GCLC Human cadmium atom increases expression EXP 6480464 Cadmium results in increased expression of GCLC mRNA CTD PMID:21120746 GCLC Human cadmium atom decreases expression ISO Gclc (Mus musculus) 6480464 Cadmium results in decreased expression of GCLC mRNA CTD PMID:37270049 GCLC Human cadmium atom increases expression ISO Gclc (Mus musculus) 6480464 Cadmium results in increased expression of GCLC mRNA CTD PMID:26363317 GCLC Human cadmium atom multiple interactions ISO Gclc (Mus musculus) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of GCLC mRNA more ... CTD PMID:33398418 GCLC Human cadmium atom multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of GCLC protein and [GCLC results in decreased uptake of Cadmium] which results in decreased expression of SLC39A8 CTD PMID:18556457 and PMID:30359721 GCLC Human cadmium atom increases expression ISO Gclc (Rattus norvegicus) 6480464 Cadmium results in increased expression of GCLC and Cadmium results in increased expression of GCLC mRNA CTD PMID:19879314 and PMID:25388156 GCLC Human cadmium dichloride multiple interactions EXP 6480464 [Cadmium Chloride co-treated with Benzo(a)pyrene] results in increased expression of GCLC mRNA more ... CTD PMID:18556457 more ... GCLC Human cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of GCLC mRNA CTD PMID:38568856 GCLC Human cadmium dichloride multiple interactions ISO Gclc (Mus musculus) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of GCLC mRNA more ... CTD PMID:33398418 GCLC Human cadmium dichloride decreases expression ISO Gclc (Rattus norvegicus) 6480464 Cadmium Chloride results in decreased expression of GCLC mRNA CTD PMID:25993096 GCLC Human cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of GCLC mRNA and Cadmium Chloride results in increased expression of GCLC protein CTD PMID:24291162 more ... GCLC Human cadmium dichloride increases expression ISO Gclc (Mus musculus) 6480464 Cadmium Chloride results in increased expression of GCLC mRNA and Cadmium Chloride results in increased expression of GCLC protein CTD PMID:22677785 and PMID:29486218 GCLC Human cadmium dichloride increases expression ISO Gclc (Rattus norvegicus) 6480464 Cadmium Chloride results in increased expression of GCLC mRNA CTD PMID:11254161 GCLC Human cadmium dichloride multiple interactions ISO Gclc (Rattus norvegicus) 6480464 Cadmium Chloride results in increased expression of and results in increased activity of GCLC protein and GCLC affects the reaction [NFE2L2 protein results in decreased susceptibility to Cadmium Chloride] CTD PMID:11254161 and PMID:19682480 GCLC Human cadmium dichloride decreases uptake EXP 6480464 GCLC results in decreased uptake of Cadmium Chloride CTD PMID:18556457 GCLC Human cadmium dichloride decreases response to substance EXP 6480464 GCLC results in decreased susceptibility to Cadmium Chloride CTD PMID:18556457 GCLC Human cadmium sulfate multiple interactions EXP 6480464 [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of GCLC mRNA CTD PMID:18654764 GCLC Human cadmium sulfate increases expression ISO Gclc (Mus musculus) 6480464 cadmium sulfate results in increased expression of GCLC mRNA CTD PMID:16221973 GCLC Human cadmium sulfate increases expression EXP 6480464 cadmium sulfate results in increased expression of GCLC mRNA CTD PMID:12064557 GCLC Human cadmium sulfide decreases expression EXP 6480464 cadmium sulfide results in decreased expression of GCLC mRNA CTD PMID:27866839 GCLC Human cafestol multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [cafestol co-treated with kahweol] inhibits the reaction [ochratoxin A results in decreased expression of GCLC protein] CTD PMID:17110534 GCLC Human caffeine multiple interactions ISO Gclc (Mus musculus) 6480464 [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GCLC mRNA CTD PMID:28843594 GCLC Human caffeine decreases phosphorylation EXP 6480464 Caffeine results in decreased phosphorylation of GCLC protein CTD PMID:35688186 GCLC Human calcitriol multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [Calcium co-treated with Calcitriol] affects the expression of GCLC mRNA CTD PMID:15913539 GCLC Human calcium atom multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [Calcium co-treated with Calcitriol] affects the expression of GCLC mRNA CTD PMID:15913539 GCLC Human calcium(0) multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [Calcium co-treated with Calcitriol] affects the expression of GCLC mRNA CTD PMID:15913539 GCLC Human cannabidiol increases expression EXP 6480464 Cannabidiol results in increased expression of GCLC mRNA CTD PMID:31518892 GCLC Human captan increases expression ISO Gclc (Mus musculus) 6480464 Captan results in increased expression of GCLC mRNA CTD PMID:31558096 GCLC Human carbamazepine affects expression EXP 6480464 Carbamazepine affects the expression of GCLC mRNA CTD PMID:24752500 GCLC Human carbon disulfide increases expression ISO Gclc (Rattus norvegicus) 6480464 Carbon Disulfide results in increased expression of GCLC mRNA CTD PMID:27530093 GCLC Human carbon monoxide multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [NFE2L2 protein co-treated with Carbon Monoxide] results in increased expression of GCLC mRNA CTD PMID:34032369 GCLC Human carbon monoxide increases expression ISO Gclc (Rattus norvegicus) 6480464 Carbon Monoxide results in increased expression of GCLC mRNA CTD PMID:34032369 GCLC Human carbon nanotube decreases expression ISO Gclc (Mus musculus) 6480464 Nanotubes more ... CTD PMID:25620056 GCLC Human carbon nanotube increases expression ISO Gclc (Mus musculus) 6480464 Nanotubes more ... CTD PMID:25554681 GCLC Human carmustine multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [Buthionine Sulfoximine co-treated with Carmustine] results in decreased activity of GCLC protein and [Carmustine co-treated with Buthionine Sulfoximine] results in decreased activity of GCLC protein CTD PMID:12967637 and PMID:16288907 GCLC Human carnosic acid multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GCLC protein] more ... CTD PMID:25446857 more ... GCLC Human carnosic acid multiple interactions ISO Gclc (Rattus norvegicus) 6480464 salvin inhibits the reaction [Oxidopamine results in decreased expression of GCLC protein] CTD PMID:25446857 GCLC Human carnosic acid increases expression ISO Gclc (Mus musculus) 6480464 salvin results in increased expression of GCLC mRNA CTD PMID:18329808 GCLC Human carnosic acid increases expression EXP 6480464 salvin results in increased expression of GCLC protein CTD PMID:26577515 and PMID:26686574 GCLC Human Carnosol increases expression EXP 6480464 carnosol results in increased expression of GCLC mRNA CTD PMID:20116392 GCLC Human celastrol multiple interactions ISO Gclc (Rattus norvegicus) 6480464 celastrol inhibits the reaction [Doxorubicin results in decreased expression of GCLC mRNA] and celastrol inhibits the reaction [Doxorubicin results in decreased expression of GCLC protein] CTD PMID:30588110 GCLC Human ceric oxide decreases expression ISO Gclc (Rattus norvegicus) 6480464 ceric oxide results in decreased expression of GCLC mRNA CTD PMID:29463257 GCLC Human cerium trichloride multiple interactions EXP 6480464 [cerous chloride co-treated with lanthanum chloride] results in increased expression of GCLC mRNA CTD PMID:28954213 GCLC Human cerium trichloride increases expression EXP 6480464 cerous chloride results in increased expression of GCLC mRNA CTD PMID:28954213 GCLC Human chenodeoxycholic acid multiple interactions EXP 6480464 [Chenodeoxycholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione CTD PMID:17724089 GCLC Human chenodeoxycholic acid increases expression EXP 6480464 Chenodeoxycholic Acid results in increased expression of GCLC protein CTD PMID:17724089 GCLC Human CHIR 99021 multiple interactions EXP 6480464 [4-(2-(5 more ... CTD PMID:34480604 GCLC Human chlorambucil multiple interactions EXP 6480464 [GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Chlorambucil CTD PMID:10900222 GCLC Human chloroacetaldehyde increases expression EXP 6480464 chloroacetaldehyde results in increased expression of GCLC mRNA CTD PMID:25596134 GCLC Human Chloroacetonitrile increases expression EXP 6480464 chloroacetonitrile results in increased expression of GCLC mRNA CTD PMID:35842135 GCLC Human chlorogenic acid increases expression EXP 6480464 Chlorogenic Acid results in increased expression of GCLC mRNA CTD PMID:29136249 GCLC Human chlorogenic acid multiple interactions EXP 6480464 Chlorogenic Acid promotes the reaction [Acetaminophen results in increased expression of GCLC mRNA] CTD PMID:29136249 GCLC Human chlorohydrocarbon decreases activity EXP 6480464 Hydrocarbons and Chlorinated analog results in decreased activity of GCLC protein CTD PMID:24355586 GCLC Human chlorohydrocarbon multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Hydrocarbons and Chlorinated analog results in increased expression of GCLC protein] CTD PMID:24355586 GCLC Human chloroprene increases expression ISO Gclc (Rattus norvegicus) 6480464 Chloroprene results in increased expression of GCLC mRNA CTD PMID:23125180 GCLC Human chloroprene increases expression ISO Gclc (Mus musculus) 6480464 Chloroprene results in increased expression of GCLC mRNA CTD PMID:23125180 GCLC Human chlorpromazine decreases expression ISO Gclc (Rattus norvegicus) 6480464 Chlorpromazine results in decreased expression of GCLC mRNA CTD PMID:25596134 GCLC Human chlorpyrifos multiple interactions ISO Gclc (Mus musculus) 6480464 Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of GCLC mRNA] CTD PMID:32955216 GCLC Human chlorpyrifos decreases expression ISO Gclc (Mus musculus) 6480464 Chlorpyrifos results in decreased expression of GCLC mRNA CTD PMID:32955216 and PMID:37019170 GCLC Human cholesterol increases expression ISO Gclc (Mus musculus) 6480464 Cholesterol results in increased expression of GCLC protein CTD PMID:29486218 GCLC Human choline multiple interactions ISO Gclc (Mus musculus) 6480464 [Choline deficiency co-treated with Methionine deficiency] results in increased expression of GCLC mRNA and NFE2L2 affects the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of GCLC mRNA] CTD PMID:20350562 GCLC Human chromium atom multiple interactions EXP 6480464 [chromous chloride results in increased abundance of Chromium] which results in decreased expression of GCLC protein CTD PMID:30359721 GCLC Human chromium trinitrate increases expression EXP 6480464 chromium nitrate results in increased expression of GCLC mRNA CTD PMID:20491607 GCLC Human chromium(6+) multiple interactions ISO Gclc (Mus musculus) 6480464 [Arsenates co-treated with chromium hexavalent ion] results in increased expression of GCLC mRNA more ... CTD PMID:19895865 and PMID:25820237 GCLC Human chromium(6+) increases expression ISO Gclc (Rattus norvegicus) 6480464 chromium hexavalent ion results in increased expression of GCLC protein CTD PMID:18306314 GCLC Human chrysin multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]] more ... CTD PMID:22864849 and PMID:33121995 GCLC Human chrysin increases expression ISO Gclc (Rattus norvegicus) 6480464 chrysin results in increased expression of GCLC mRNA and chrysin results in increased expression of GCLC protein CTD PMID:22864849 GCLC Human cidofovir anhydrous decreases expression EXP 6480464 Cidofovir results in decreased expression of GCLC mRNA CTD PMID:25596134 GCLC Human cinnamyl alcohol increases expression EXP 6480464 cinnamyl alcohol results in increased expression of GCLC mRNA CTD PMID:20566472 GCLC Human ciprofibrate decreases activity ISO Gclc (Rattus norvegicus) 6480464 ciprofibrate results in decreased activity of GCLC protein CTD PMID:7676460 GCLC Human ciprofibrate decreases expression ISO Gclc (Rattus norvegicus) 6480464 ciprofibrate results in decreased expression of GCLC mRNA CTD PMID:7676460 GCLC Human cisplatin multiple interactions EXP 6480464 astilbin inhibits the reaction [Cisplatin results in decreased expression of GCLC mRNA] more ... CTD PMID:17628013 more ... GCLC Human cisplatin decreases expression ISO Gclc (Mus musculus) 6480464 Cisplatin results in decreased expression of GCLC mRNA CTD PMID:32428544 GCLC Human cisplatin decreases response to substance EXP 6480464 GCLC protein results in decreased susceptibility to Cisplatin CTD PMID:29549912 GCLC Human cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of GCLC mRNA CTD PMID:27480280 and PMID:28959534 GCLC Human cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of GCLC mRNA CTD PMID:25596134 and PMID:29471006 GCLC Human cisplatin increases expression ISO Gclc (Mus musculus) 6480464 Cisplatin results in increased expression of GCLC mRNA and Cisplatin results in increased expression of GCLC protein CTD PMID:20605904 GCLC Human cisplatin multiple interactions ISO Gclc (Mus musculus) 6480464 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of GCLC mRNA] more ... CTD PMID:20605904 and PMID:32428544 GCLC Human cisplatin increases phosphorylation ISO Gclc (Mus musculus) 6480464 Cisplatin results in increased phosphorylation of GCLC protein CTD PMID:22006019 GCLC Human citraconic acid increases expression ISO Gclc (Rattus norvegicus) 6480464 citraconic acid results in increased expression of GCLC protein CTD PMID:27277809 GCLC Human citraconic acid increases expression ISO Gclc (Mus musculus) 6480464 citraconic acid results in increased expression of GCLC mRNA CTD PMID:27277809 GCLC Human clavulanic acid increases expression EXP 6480464 Clavulanic Acid results in increased expression of GCLC mRNA CTD PMID:34767876 GCLC Human Clivoline multiple interactions EXP 6480464 [clivorine co-treated with Quercetin] results in increased expression of GCLC mRNA and pyrazolanthrone inhibits the reaction [[clivorine co-treated with Quercetin] results in increased expression of GCLC mRNA] CTD PMID:25881548 GCLC Human clobetasol decreases expression EXP 6480464 Clobetasol results in decreased expression of GCLC mRNA CTD PMID:16882163 GCLC Human clodronic acid decreases expression EXP 6480464 Clodronic Acid results in decreased expression of GCLC mRNA CTD PMID:25596134 GCLC Human cobalt dichloride multiple interactions EXP 6480464 [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of GCLC mRNA more ... CTD PMID:18654764 and PMID:29966676 GCLC Human cobalt dichloride increases expression ISO Gclc (Rattus norvegicus) 6480464 cobaltous chloride results in increased expression of GCLC mRNA CTD PMID:24386269 GCLC Human cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of GCLC mRNA CTD PMID:19320972 and PMID:29966676 GCLC Human cocaine increases expression ISO Gclc (Mus musculus) 6480464 Cocaine results in increased expression of GCLC mRNA CTD PMID:30393195 GCLC Human cocaine multiple interactions ISO Gclc (Mus musculus) 6480464 PRKCD protein affects the reaction [Cocaine results in increased expression of GCLC mRNA] and rottlerin promotes the reaction [Cocaine results in increased expression of GCLC mRNA] CTD PMID:30393195 GCLC Human coniferyl aldehyde increases expression EXP 6480464 coniferaldehyde results in increased expression of GCLC mRNA CTD PMID:26275128 GCLC Human conjugated linoleic acid increases expression EXP 6480464 Linoleic Acids and Conjugated results in increased expression of GCLC mRNA CTD PMID:17092368 GCLC Human conjugated linoleic acid multiple interactions EXP 6480464 [Linoleic Acids and Conjugated results in increased activity of GCLC protein] which results in decreased susceptibility to tert-Butylhydroperoxide CTD PMID:17092368 GCLC Human conjugated linoleic acid increases activity EXP 6480464 Linoleic Acids and Conjugated results in increased activity of GCLC protein CTD PMID:17092368 GCLC Human copper atom decreases expression ISO Gclc (Rattus norvegicus) 6480464 Copper results in decreased expression of GCLC mRNA CTD PMID:22465980 GCLC Human copper atom multiple interactions EXP 6480464 [Chelating Agents binds to Copper] which results in increased expression of GCLC mRNA more ... CTD PMID:19747488 more ... GCLC Human copper atom increases expression EXP 6480464 Copper results in increased expression of GCLC mRNA CTD PMID:19747488 GCLC Human copper(0) decreases expression ISO Gclc (Rattus norvegicus) 6480464 Copper results in decreased expression of GCLC mRNA CTD PMID:22465980 GCLC Human copper(0) multiple interactions EXP 6480464 [Chelating Agents binds to Copper] which results in increased expression of GCLC mRNA more ... CTD PMID:19747488 more ... GCLC Human copper(0) increases expression EXP 6480464 Copper results in increased expression of GCLC mRNA CTD PMID:19747488 GCLC Human copper(II) chloride increases expression EXP 6480464 cupric chloride results in increased expression of GCLC mRNA CTD PMID:17211630 and PMID:38568856 GCLC Human copper(II) sulfate increases expression EXP 6480464 Copper Sulfate results in increased expression of GCLC mRNA CTD PMID:19549813 GCLC Human cortisol increases expression ISO Gclc (Rattus norvegicus) 6480464 Hydrocortisone results in increased expression of GCLC mRNA CTD PMID:10978506 GCLC Human cortisol multiple interactions EXP 6480464 [4-(2-(5 more ... CTD PMID:34480604 GCLC Human coumarin increases expression ISO Gclc (Rattus norvegicus) 6480464 coumarin results in increased expression of GCLC mRNA CTD PMID:18480146 GCLC Human crocidolite asbestos increases expression ISO Gclc (Mus musculus) 6480464 Asbestos more ... CTD PMID:15520183 GCLC Human crocidolite asbestos multiple interactions ISO Gclc (Mus musculus) 6480464 [GCLC protein co-treated with GCLM protein] inhibits the reaction [Asbestos more ... CTD PMID:15520183 GCLC Human cumene hydroperoxide increases expression ISO Gclc (Mus musculus) 6480464 cumene hydroperoxide results in increased expression of GCLC mRNA CTD PMID:30547568 GCLC Human curcumin increases activity EXP 6480464 Curcumin results in increased activity of GCLC protein CTD PMID:10514034 GCLC Human curcumin multiple interactions ISO Gclc (Mus musculus) 6480464 Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of GCLC mRNA] more ... CTD PMID:29571711 more ... GCLC Human curcumin increases expression EXP 6480464 Curcumin analog results in increased expression of GCLC mRNA and Curcumin results in increased expression of GCLC mRNA CTD PMID:23710286 and PMID:23954767 GCLC Human curcumin multiple interactions EXP 6480464 Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of GCLC mRNA] more ... CTD PMID:23954767 and PMID:31521693 GCLC Human curcumin increases expression ISO Gclc (Rattus norvegicus) 6480464 Curcumin results in increased expression of GCLC mRNA and Curcumin results in increased expression of GCLC protein CTD PMID:17602960 more ... GCLC Human curcumin multiple interactions ISO Gclc (Rattus norvegicus) 6480464 Curcumin inhibits the reaction [Ketamine results in decreased expression of GCLC mRNA] more ... CTD PMID:17602960 more ... GCLC Human curcumin increases expression ISO Gclc (Mus musculus) 6480464 Curcumin results in increased expression of GCLC mRNA and Curcumin results in increased expression of GCLC protein CTD PMID:19168576 more ... GCLC Human cycloheximide multiple interactions ISO Gclc (Mus musculus) 6480464 Cycloheximide inhibits the reaction [arsenite results in increased activity of [GCLC protein binds to GCLM protein]] more ... CTD PMID:17628625 and PMID:19328227 GCLC Human cycloheximide multiple interactions ISO Gclc (Rattus norvegicus) 6480464 Cycloheximide inhibits the reaction [notoginsenoside R1 results in increased expression of GCLC protein] CTD PMID:24437944 GCLC Human cyclophosphamide multiple interactions ISO Gclc (Mus musculus) 6480464 Cyclophosphamide promotes the reaction [NFE2L2 gene mutant form results in decreased expression of GCLC protein] CTD PMID:27633142 GCLC Human cyclophosphamide decreases expression ISO Gclc (Mus musculus) 6480464 Cyclophosphamide results in decreased expression of GCLC mRNA and Cyclophosphamide results in decreased expression of GCLC protein CTD PMID:27633142 GCLC Human cyclosporin A decreases expression ISO Gclc (Rattus norvegicus) 6480464 Cyclosporine results in decreased expression of GCLC mRNA CTD PMID:11589784 and PMID:25596134 GCLC Human cyclosporin A increases expression EXP 6480464 Cyclosporine results in increased expression of GCLC mRNA CTD PMID:20106945 more ... GCLC Human cyhalothrin multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of GCLC protein CTD PMID:34896426 GCLC Human cylindrospermopsin increases expression EXP 6480464 cylindrospermopsin results in increased expression of GCLC mRNA CTD PMID:23726867 and PMID:32244372 GCLC Human cylindrospermopsin multiple interactions EXP 6480464 [4 more ... CTD PMID:32244372 GCLC Human cylindrospermopsin increases expression ISO Gclc (Mus musculus) 6480464 cylindrospermopsin results in increased expression of GCLC mRNA CTD PMID:20936652 GCLC Human cypermethrin multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of GCLC protein CTD PMID:34896426 GCLC Human cysteamine decreases activity ISO Gclc (Mus musculus) 6480464 Cysteamine results in decreased activity of GCLC protein CTD PMID:15282320 GCLC Human cysteamine multiple interactions ISO Gclc (Mus musculus) 6480464 [Cysteamine results in decreased activity of GCLC protein] which results in decreased abundance of Glutathione CTD PMID:15282320 GCLC Human D-glucose multiple interactions ISO Gclc (Mus musculus) 6480464 [Glucose co-treated with gastrodin] affects the expression of GCLC mRNA CTD PMID:33764184 GCLC Human D-glucose multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [Glucose co-treated with gastrodin] affects the expression of GCLC mRNA CTD PMID:33764184 GCLC Human DDE decreases expression EXP 6480464 Dichlorodiphenyl Dichloroethylene results in decreased expression of GCLC mRNA and Dichlorodiphenyl Dichloroethylene results in decreased expression of GCLC protein CTD PMID:25263748 GCLC Human DDE multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in decreased expression of GCLC mRNA] more ... CTD PMID:25263748 GCLC Human DDT increases expression EXP 6480464 DDT results in increased expression of GCLC mRNA CTD PMID:26198647 GCLC Human DDT increases expression ISO Gclc (Rattus norvegicus) 6480464 DDT results in increased expression of GCLC mRNA CTD PMID:29477483 GCLC Human deguelin increases expression EXP 6480464 deguelin results in increased expression of GCLC mRNA CTD PMID:33512557 GCLC Human deoxycholic acid multiple interactions EXP 6480464 [Deoxycholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA CTD PMID:17724089 GCLC Human Deoxycorticosterone acetate multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [Desoxycorticosterone Acetate co-treated with Sodium Chloride and Dietary co-treated with Potassium Chloride] results in decreased expression of GCLC mRNA CTD PMID:22228705 GCLC Human deoxynivalenol decreases expression ISO Gclc (Mus musculus) 6480464 deoxynivalenol results in decreased expression of GCLC mRNA CTD PMID:35817260 GCLC Human deoxynivalenol multiple interactions EXP 6480464 Resveratrol inhibits the reaction [deoxynivalenol results in decreased expression of GCLC protein] CTD PMID:37419272 GCLC Human deoxynivalenol decreases expression EXP 6480464 deoxynivalenol results in decreased expression of GCLC mRNA CTD PMID:37419272 GCLC Human deoxynivalenol multiple interactions ISO Gclc (Mus musculus) 6480464 Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of GCLC mRNA] CTD PMID:35817260 GCLC Human desferrioxamine B multiple interactions ISO Gclc (Mus musculus) 6480464 Deferoxamine inhibits the reaction [Benzene results in decreased expression of GCLC mRNA] CTD PMID:35661779 GCLC Human dexamethasone multiple interactions ISO Gclc (Mus musculus) 6480464 [Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of GCLC mRNA more ... CTD PMID:16054899 and PMID:33412187 GCLC Human dexamethasone multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of GCLC mRNA more ... CTD PMID:27028516 GCLC Human dextran sulfate multiple interactions ISO Gclc (Mus musculus) 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of GCLC mRNA CTD PMID:29950665 GCLC Human dextromethorphan multiple interactions ISO Gclc (Mus musculus) 6480464 PRKCD protein affects the reaction [Dextromethorphan affects the expression of GCLC mRNA] more ... CTD PMID:34740715 GCLC Human dextromethorphan affects expression ISO Gclc (Mus musculus) 6480464 Dextromethorphan affects the expression of GCLC mRNA CTD PMID:34740715 GCLC Human Di-n-octyl phthalate multiple interactions ISO Gclc (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in decreased expression of GCLC mRNA CTD PMID:37364641 GCLC Human diallyl disulfide multiple interactions ISO Gclc (Rattus norvegicus) 6480464 diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA] CTD PMID:24293383 GCLC Human diallyl disulfide increases expression EXP 6480464 diallyl disulfide results in increased expression of GCLC mRNA CTD PMID:34887701 GCLC Human diallyl disulfide multiple interactions ISO Gclc (Mus musculus) 6480464 [diallyl disulfide co-treated with lipopolysaccharide more ... CTD PMID:34896185 GCLC Human diallyl disulfide increases expression ISO Gclc (Mus musculus) 6480464 diallyl disulfide results in increased expression of GCLC mRNA and diallyl disulfide results in increased expression of GCLC protein CTD PMID:34896185 and PMID:35526736 GCLC Human Diallyl sulfide multiple interactions ISO Gclc (Rattus norvegicus) 6480464 allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of GCLC mRNA] and allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of GCLC protein] CTD PMID:31585129 GCLC Human Diallyl sulfide multiple interactions ISO Gclc (Mus musculus) 6480464 allyl sulfide inhibits the reaction [[ethylene dichloride co-treated with Ethanol] results in increased expression of GCLC protein] CTD PMID:37150348 GCLC Human diallyl trisulfide increases expression ISO Gclc (Rattus norvegicus) 6480464 diallyl trisulfide results in increased expression of GCLC mRNA CTD PMID:34014027 GCLC Human diallyl trisulfide increases expression EXP 6480464 diallyl trisulfide results in increased expression of GCLC mRNA CTD PMID:34887701 GCLC Human Diallyltetrasulfane increases expression EXP 6480464 diallyl tetrasulfide results in increased expression of GCLC mRNA CTD PMID:34887701 GCLC Human diarsenic trioxide multiple interactions EXP 6480464 [Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of GCLC mRNA and [Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of GCLC protein CTD PMID:33434570 GCLC Human diarsenic trioxide increases expression EXP 6480464 Arsenic Trioxide results in increased expression of GCLC mRNA and Arsenic Trioxide results in increased expression of GCLC protein CTD PMID:19417148 more ... GCLC Human diarsenic trioxide decreases response to substance EXP 6480464 GCLC protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:20707922 and PMID:29549912 GCLC Human diarsenic trioxide increases expression ISO Gclc (Mus musculus) 6480464 Arsenic Trioxide results in increased expression of GCLC mRNA CTD PMID:29049341 GCLC Human diarsenic trioxide multiple interactions ISO Gclc (Mus musculus) 6480464 NFE2L2 protein affects the reaction [Arsenic Trioxide results in increased expression of GCLC mRNA] CTD PMID:29049341 GCLC Human diarsenic trioxide decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of GCLC protein CTD PMID:25341331 and PMID:25419056 GCLC Human diazinon increases expression EXP 6480464 Diazinon results in increased expression of GCLC mRNA CTD PMID:26198647 GCLC Human dibenzoylmethane multiple interactions ISO Gclc (Mus musculus) 6480464 [sulforaphane co-treated with dibenzoylmethane] results in increased expression of GCLC mRNA CTD PMID:17942926 GCLC Human dibenzoylmethane increases expression ISO Gclc (Mus musculus) 6480464 dibenzoylmethane results in increased expression of GCLC mRNA CTD PMID:17942926 GCLC Human Dibromoacetonitrile increases expression EXP 6480464 dibromoacetonitrile results in increased expression of GCLC mRNA CTD PMID:35842135 GCLC Human dibutyl phthalate increases expression ISO Gclc (Rattus norvegicus) 6480464 Dibutyl Phthalate results in increased expression of GCLC mRNA CTD PMID:21266533 GCLC Human dibutyl phthalate multiple interactions ISO Gclc (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in decreased expression of GCLC mRNA CTD PMID:37364641 GCLC Human Dichloroacetonitrile increases expression EXP 6480464 dichloroacetonitrile results in increased expression of GCLC mRNA CTD PMID:35842135 GCLC Human dichloromethane multiple interactions ISO Gclc (Mus musculus) 6480464 [[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which results in decreased expression of GCLC mRNA CTD PMID:29335169 GCLC Human diclofenac decreases expression ISO Gclc (Rattus norvegicus) 6480464 Diclofenac results in decreased expression of GCLC mRNA CTD PMID:17202759 GCLC Human diclofenac affects expression EXP 6480464 Diclofenac affects the expression of GCLC mRNA CTD PMID:24752500 GCLC Human diclofenac affects response to substance ISO Gclc (Rattus norvegicus) 6480464 GCLC protein affects the susceptibility to Diclofenac CTD PMID:19481141 GCLC Human diethyl malate affects expression ISO Gclc (Mus musculus) 6480464 diethyl malate affects the expression of GCLC mRNA CTD PMID:24814887 GCLC Human diethyl maleate increases expression ISO Gclc (Rattus norvegicus) 6480464 diethyl maleate results in increased expression of GCLC mRNA and diethyl maleate results in increased expression of GCLC protein CTD PMID:10978506 more ... GCLC Human diethyl maleate increases expression EXP 6480464 diethyl maleate results in increased expression of GCLC mRNA and diethyl maleate results in increased expression of GCLC protein CTD PMID:33545341 more ... GCLC Human diethyl maleate increases expression ISO Gclc (Mus musculus) 6480464 diethyl maleate results in increased expression of GCLC mRNA and diethyl maleate results in increased expression of GCLC protein CTD PMID:10915739 and PMID:25270620 GCLC Human diethyl maleate increases activity ISO Gclc (Mus musculus) 6480464 diethyl maleate results in increased activity of GCLC protein CTD PMID:10915739 GCLC Human diethyl maleate increases activity ISO Gclc (Rattus norvegicus) 6480464 diethyl maleate results in increased activity of GCLC protein CTD PMID:15115889 GCLC Human diethyl phthalate multiple interactions ISO Gclc (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in decreased expression of GCLC mRNA CTD PMID:37364641 GCLC Human diethyl sulfate increases expression EXP 6480464 diethyl sulfate results in increased expression of GCLC mRNA CTD PMID:20491607 GCLC Human diethylstilbestrol increases expression ISO Gclc (Rattus norvegicus) 6480464 Diethylstilbestrol results in increased expression of GCLC mRNA CTD PMID:15890375 GCLC Human diethylstilbestrol increases expression EXP 6480464 Diethylstilbestrol results in increased expression of GCLC mRNA CTD PMID:26198647 GCLC Human dihydrogen multiple interactions ISO Gclc (Mus musculus) 6480464 Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of GCLC mRNA] CTD PMID:32955216 GCLC Human Diisodecyl phthalate multiple interactions ISO Gclc (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in decreased expression of GCLC mRNA CTD PMID:37364641 GCLC Human diisononyl phthalate multiple interactions ISO Gclc (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in decreased expression of GCLC mRNA CTD PMID:37364641 GCLC Human Dimerumic acid increases expression ISO Gclc (Mus musculus) 6480464 dimerumic acid results in increased expression of GCLC mRNA CTD PMID:24036144 GCLC Human Dimerumic acid multiple interactions ISO Gclc (Mus musculus) 6480464 NFE2L2 protein affects the reaction [dimerumic acid results in increased expression of GCLC mRNA] CTD PMID:24036144 GCLC Human Dimerumic acid increases activity ISO Gclc (Mus musculus) 6480464 dimerumic acid results in increased activity of GCLC protein CTD PMID:24036144 GCLC Human dimethyl fumarate increases expression ISO Gclc (Rattus norvegicus) 6480464 Dimethyl Fumarate results in increased expression of GCLC protein CTD PMID:27277809 GCLC Human dimethyl fumarate multiple interactions ISO Gclc (Mus musculus) 6480464 NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GCLC mRNA] CTD PMID:27277809 GCLC Human dimethyl fumarate increases expression ISO Gclc (Mus musculus) 6480464 Dimethyl Fumarate results in increased expression of GCLC mRNA CTD PMID:27277809 and PMID:30248482 GCLC Human dimethylarsinic acid multiple interactions EXP 6480464 [Cacodylic Acid results in increased abundance of Arsenic] which results in increased expression of GCLC protein CTD PMID:33434570 GCLC Human dinoseb increases expression ISO Gclc (Mus musculus) 6480464 dinoseb results in increased expression of GCLC mRNA CTD PMID:30547568 GCLC Human dioxygen multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [Oxygen deficiency co-treated with Oxygen] results in increased expression of GCLC protein more ... CTD PMID:25773745 GCLC Human dioxygen multiple interactions EXP 6480464 [Oxygen deficiency co-treated with Catechin] results in increased expression of GCLC mRNA CTD PMID:35883890 GCLC Human dioxygen decreases expression EXP 6480464 Oxygen deficiency results in decreased expression of GCLC mRNA CTD PMID:35883890 GCLC Human dioxygen increases expression EXP 6480464 Oxygen deficiency results in increased expression of GCLC mRNA CTD PMID:25596134 and PMID:29966676 GCLC Human dioxygen multiple interactions ISO Gclc (Mus musculus) 6480464 [Oxygen deficiency co-treated with Oxygen] results in increased expression of GCLC mRNA CTD PMID:25922074 GCLC Human dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate increases expression EXP 6480464 Antimony Potassium Tartrate results in increased expression of GCLC mRNA and Antimony Potassium Tartrate results in increased expression of GCLC protein CTD PMID:28713220 GCLC Human dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate multiple interactions EXP 6480464 [Antimony Potassium Tartrate results in increased abundance of antimonite] which results in increased expression of GCLC mRNA CTD PMID:32076005 GCLC Human diprotium multiple interactions ISO Gclc (Mus musculus) 6480464 Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of GCLC mRNA] CTD PMID:32955216 GCLC Human diprotium oxide multiple interactions ISO Gclc (Mus musculus) 6480464 [[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in increased expression of GCLC mRNA CTD PMID:29335169 GCLC Human diquat increases expression ISO Gclc (Mus musculus) 6480464 Diquat results in increased expression of GCLC mRNA CTD PMID:16962985 GCLC Human diquat increases expression EXP 6480464 Diquat results in increased expression of GCLC protein CTD PMID:38128689 GCLC Human diquat multiple interactions ISO Gclc (Mus musculus) 6480464 [KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]] which results in increased expression of GCLC mRNA CTD PMID:22762311 GCLC Human diquat decreases activity ISO Gclc (Rattus norvegicus) 6480464 Diquat results in decreased activity of GCLC protein CTD PMID:7676460 GCLC Human diquat decreases expression ISO Gclc (Rattus norvegicus) 6480464 Diquat results in decreased expression of GCLC mRNA CTD PMID:7676460 GCLC Human disodium selenite increases expression ISO Gclc (Mus musculus) 6480464 Sodium Selenite results in increased expression of GCLC mRNA CTD PMID:18449455 GCLC Human disodium selenite increases expression EXP 6480464 Sodium Selenite results in increased expression of GCLC mRNA CTD PMID:24383545 GCLC Human disulfiram increases expression EXP 6480464 Disulfiram results in increased expression of GCLC mRNA CTD PMID:20566472 GCLC Human diuron increases expression ISO Gclc (Rattus norvegicus) 6480464 Diuron results in increased expression of GCLC mRNA CTD PMID:21551480 GCLC Human domoic acid increases expression ISO Gclc (Mus musculus) 6480464 domoic acid results in increased expression of GCLC mRNA and domoic acid results in increased expression of GCLC protein CTD PMID:23315585 GCLC Human dopamine multiple interactions EXP 6480464 Dopamine promotes the reaction [Zinc deficiency results in increased cleavage of GCLC protein] CTD PMID:23377617 GCLC Human doramapimod increases expression ISO Gclc (Mus musculus) 6480464 doramapimod results in increased expression of GCLC mRNA CTD PMID:21328587 GCLC Human dorsomorphin multiple interactions EXP 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:24211276 and PMID:27188386 GCLC Human dorsomorphin multiple interactions ISO Gclc (Mus musculus) 6480464 [Acetaminophen co-treated with amlexanox co-treated with dorsomorphin] affects the expression of GCLC mRNA CTD PMID:31697998 GCLC Human doxorubicin multiple interactions ISO Gclc (Rattus norvegicus) 6480464 celastrol inhibits the reaction [Doxorubicin results in decreased expression of GCLC mRNA] more ... CTD PMID:18371937 more ... GCLC Human doxorubicin decreases expression ISO Gclc (Mus musculus) 6480464 Doxorubicin results in decreased expression of GCLC mRNA CTD PMID:37499777 GCLC Human doxorubicin decreases response to substance EXP 6480464 GCLC protein results in decreased susceptibility to Doxorubicin CTD PMID:29549912 GCLC Human doxorubicin decreases expression ISO Gclc (Rattus norvegicus) 6480464 Doxorubicin results in decreased expression of GCLC mRNA and Doxorubicin results in decreased expression of GCLC protein CTD PMID:18371937 more ... GCLC Human doxorubicin multiple interactions ISO Gclc (Mus musculus) 6480464 ABCC1 gene mutant form promotes the reaction [Doxorubicin results in increased expression of GCLC protein] and FNDC5 protein inhibits the reaction [Doxorubicin results in decreased expression of GCLC mRNA] CTD PMID:26822305 and PMID:37499777 GCLC Human doxorubicin increases expression ISO Gclc (Mus musculus) 6480464 Doxorubicin results in increased expression of GCLC protein CTD PMID:26822305 GCLC Human doxorubicin multiple interactions EXP 6480464 [GCLC protein co-treated with GCLM protein] promotes the reaction [GSTP1 protein results in decreased susceptibility to Doxorubicin] and GCLC protein inhibits the reaction [ABCC1 protein results in decreased susceptibility to Doxorubicin] CTD PMID:10900222 and PMID:11560771 GCLC Human elemental selenium multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of GCLC mRNA CTD PMID:11444866 GCLC Human emodin increases expression ISO Gclc (Rattus norvegicus) 6480464 Emodin results in increased expression of GCLC mRNA CTD PMID:34971761 GCLC Human endosulfan increases expression ISO Gclc (Rattus norvegicus) 6480464 Endosulfan results in increased expression of GCLC mRNA CTD PMID:29391264 GCLC Human enzyme inhibitor multiple interactions EXP 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of GCLC protein CTD PMID:23301498 GCLC Human epoxiconazole increases expression ISO Gclc (Mus musculus) 6480464 epoxiconazole results in increased expression of GCLC mRNA CTD PMID:35436446 GCLC Human erastin increases expression ISO Gclc (Rattus norvegicus) 6480464 erastin results in increased expression of GCLC protein CTD PMID:32937103 GCLC Human erastin multiple interactions ISO Gclc (Rattus norvegicus) 6480464 NFE2L2 protein promotes the reaction [erastin results in increased expression of GCLC protein] CTD PMID:32937103 GCLC Human erdosteine increases expression ISO Gclc (Mus musculus) 6480464 erdosteine results in increased expression of GCLC protein CTD PMID:26193055 GCLC Human etacrynic acid multiple interactions EXP 6480464 [GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Ethacrynic Acid CTD PMID:10900222 GCLC Human ethanol increases expression ISO Gclc (Rattus norvegicus) 6480464 Ethanol results in increased expression of GCLC mRNA CTD PMID:10978506 GCLC Human ethanol increases expression ISO Gclc (Mus musculus) 6480464 Ethanol results in increased expression of GCLC mRNA CTD PMID:34995708 GCLC Human ethanol affects splicing ISO Gclc (Mus musculus) 6480464 Ethanol affects the splicing of GCLC mRNA CTD PMID:30319688 GCLC Human ethanol decreases expression ISO Gclc (Mus musculus) 6480464 Ethanol results in decreased expression of GCLC mRNA CTD PMID:27983966 GCLC Human ethanol multiple interactions ISO Gclc (Mus musculus) 6480464 [ethylene dichloride co-treated with Ethanol] results in increased expression of GCLC mRNA more ... CTD PMID:27983966 more ... GCLC Human ethanol multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [Trinitrobenzenesulfonic Acid co-treated with Ethanol] results in increased expression of GCLC mRNA CTD PMID:10830784 GCLC Human ethanol increases expression EXP 6480464 Ethanol results in increased expression of GCLC mRNA CTD PMID:19133322 GCLC Human ethanol multiple interactions EXP 6480464 CYP2E1 protein promotes the reaction [Ethanol results in increased expression of GCLC mRNA] CTD PMID:19133322 GCLC Human Ethyl acrylate increases expression EXP 6480464 ethyl acrylate results in increased expression of GCLC mRNA CTD PMID:26198647 GCLC Human etoposide multiple interactions EXP 6480464 [GCLC protein co-treated with GCLM protein] promotes the reaction [ABCC1 protein results in decreased susceptibility to Etoposide] and [GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Etoposide CTD PMID:10900222 GCLC Human eugenol increases expression EXP 6480464 Eugenol results in increased expression of GCLC mRNA CTD PMID:20566472 more ... GCLC Human farnesal increases expression EXP 6480464 farnesal results in increased expression of GCLC mRNA CTD PMID:20491607 GCLC Human farrerol increases expression ISO Gclc (Mus musculus) 6480464 farrerol results in increased expression of GCLC mRNA CTD PMID:26111761 GCLC Human fenofibrate decreases expression ISO Gclc (Rattus norvegicus) 6480464 Fenofibrate results in decreased expression of GCLC mRNA CTD PMID:25596134 GCLC Human fenofibrate multiple interactions ISO Gclc (Mus musculus) 6480464 Fenofibrate inhibits the reaction [tyloxapol results in decreased expression of GCLC protein] CTD PMID:36905866 GCLC Human fenvalerate multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of GCLC protein CTD PMID:34896426 GCLC Human ferrostatin-1 multiple interactions ISO Gclc (Mus musculus) 6480464 ferrostatin-1 inhibits the reaction [Benzene results in decreased expression of GCLC mRNA] CTD PMID:35661779 GCLC Human fipronil increases expression ISO Gclc (Rattus norvegicus) 6480464 fipronil results in increased expression of GCLC mRNA CTD PMID:23962444 GCLC Human flutamide increases expression ISO Gclc (Mus musculus) 6480464 Flutamide results in increased expression of GCLC mRNA CTD PMID:17702527 GCLC Human flutamide increases expression ISO Gclc (Rattus norvegicus) 6480464 Flutamide results in increased expression of GCLC mRNA CTD PMID:24136188 GCLC Human flutamide affects response to substance ISO Gclc (Rattus norvegicus) 6480464 GCLC protein affects the susceptibility to Flutamide CTD PMID:19481141 GCLC Human folic acid multiple interactions ISO Gclc (Mus musculus) 6480464 [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of GCLC mRNA CTD PMID:22206623 GCLC Human folic acid decreases expression EXP 6480464 Folic Acid deficiency results in decreased expression of GCLC protein CTD PMID:28639913 GCLC Human folpet increases expression ISO Gclc (Mus musculus) 6480464 folpet results in increased expression of GCLC mRNA CTD PMID:31558096 GCLC Human formaldehyde increases expression EXP 6480464 Formaldehyde results in increased expression of GCLC mRNA CTD PMID:20491607 GCLC Human FR900359 decreases phosphorylation EXP 6480464 FR900359 results in decreased phosphorylation of GCLC protein CTD PMID:37730182 GCLC Human fulvestrant multiple interactions ISO Gclc (Rattus norvegicus) 6480464 fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of GCLC protein] CTD PMID:24437944 GCLC Human fumaraldehyde increases expression EXP 6480464 malealdehyde results in increased expression of GCLC mRNA CTD PMID:35750087 GCLC Human furan multiple interactions ISO Gclc (Mus musculus) 6480464 [Bromodeoxyuridine co-treated with furan] results in increased expression of GCLC mRNA CTD PMID:24910943 GCLC Human furan increases expression ISO Gclc (Rattus norvegicus) 6480464 furan results in increased expression of GCLC mRNA CTD PMID:27402187 GCLC Human furan increases expression ISO Gclc (Mus musculus) 6480464 furan results in increased expression of GCLC mRNA CTD PMID:24183702 and PMID:24910943 GCLC Human galactose multiple interactions ISO Gclc (Rattus norvegicus) 6480464 Saponins inhibits the reaction [Galactose results in decreased expression of GCLC mRNA] CTD PMID:25892055 GCLC Human galactose decreases expression ISO Gclc (Rattus norvegicus) 6480464 Galactose results in decreased expression of GCLC mRNA CTD PMID:25892055 GCLC Human gamma-hexachlorocyclohexane increases expression EXP 6480464 Hexachlorocyclohexane results in increased expression of GCLC mRNA CTD PMID:26198647 GCLC Human gamma-linolenic acid increases activity EXP 6480464 gamma-Linolenic Acid results in increased activity of GCLC protein CTD PMID:17092368 GCLC Human gamma-linolenic acid increases expression EXP 6480464 gamma-Linolenic Acid results in increased expression of GCLC mRNA CTD PMID:17092368 GCLC Human Gastrodin multiple interactions ISO Gclc (Mus musculus) 6480464 [Glucose co-treated with gastrodin] affects the expression of GCLC mRNA CTD PMID:33764184 GCLC Human Gastrodin multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [Glucose co-treated with gastrodin] affects the expression of GCLC mRNA CTD PMID:33764184 GCLC Human gefitinib affects response to substance EXP 6480464 GCLC protein affects the susceptibility to gefitinib CTD PMID:15496427 GCLC Human genistein multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [Genistein co-treated with Methoxychlor] results in increased expression of GCLC mRNA CTD PMID:21782745 GCLC Human genistein affects expression EXP 6480464 Genistein affects the expression of GCLC mRNA CTD PMID:26865667 GCLC Human genistein increases expression ISO Gclc (Rattus norvegicus) 6480464 Genistein results in increased expression of GCLC mRNA CTD PMID:21782745 GCLC Human ginsenoside Rg1 multiple interactions ISO Gclc (Mus musculus) 6480464 ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA] and NFE2L2 protein affects the reaction [ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]] CTD PMID:29964319 GCLC Human ginsenoside Rg1 increases expression ISO Gclc (Mus musculus) 6480464 ginsenoside Rg1 results in increased expression of GCLC mRNA CTD PMID:29964319 GCLC Human Ginsenoside Rh4 multiple interactions ISO Gclc (Rattus norvegicus) 6480464 ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of GCLC mRNA] more ... CTD PMID:33359794 GCLC Human Ginsenoside Rh4 multiple interactions ISO Gclc (Mus musculus) 6480464 ginsenoside Rh4 inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of GCLC mRNA] CTD PMID:33359794 GCLC Human gliclazide multiple interactions ISO Gclc (Rattus norvegicus) 6480464 Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC mRNA] and Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC protein] CTD PMID:21439372 GCLC Human glucose multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [Glucose co-treated with gastrodin] affects the expression of GCLC mRNA CTD PMID:33764184 GCLC Human glucose multiple interactions ISO Gclc (Mus musculus) 6480464 [Glucose co-treated with gastrodin] affects the expression of GCLC mRNA CTD PMID:33764184 GCLC Human glutathione increases abundance ISO Gclc (Mus musculus) 6480464 GCLC mRNA results in increased abundance of Glutathione and GCLC protein results in increased abundance of Glutathione CTD PMID:19914271 more ... GCLC Human glutathione increases expression ISO Gclc (Rattus norvegicus) 6480464 Glutathione deficiency results in increased expression of GCLC mRNA CTD PMID:15345336 and PMID:20621112 GCLC Human glutathione affects chemical synthesis EXP 6480464 GCLC polymorphism affects the chemical synthesis of Glutathione CTD PMID:16599007 GCLC Human glutathione increases abundance EXP 6480464 GCLC results in increased abundance of Glutathione CTD PMID:18556457 GCLC Human glutathione multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [HGF protein results in increased activity of GCLC protein] which results in increased chemical synthesis of Glutathione CTD PMID:10544272 GCLC Human glutathione multiple interactions EXP 6480464 [[[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein] which results in increased abundance of Glutathione more ... CTD PMID:11673643 more ... GCLC Human glutathione multiple interactions ISO Gclc (Mus musculus) 6480464 [2-tert-butylhydroquinone results in increased activity of GCLC protein] which results in increased abundance of Glutathione more ... CTD PMID:14978233 more ... GCLC Human Glutathione ethyl ester multiple interactions ISO Gclc (Mus musculus) 6480464 S-ethyl glutathione inhibits the reaction [Hypochlorous Acid results in increased expression of GCLC mRNA] CTD PMID:17980396 GCLC Human glycerol 2-phosphate multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of GCLC mRNA more ... CTD PMID:27028516 GCLC Human guggulsterone increases expression ISO Gclc (Mus musculus) 6480464 pregna-4 more ... CTD PMID:22851183 GCLC Human guggulsterone increases expression EXP 6480464 pregna-4 more ... CTD PMID:22851183 GCLC Human hemin increases expression EXP 6480464 Hemin results in increased expression of GCLC mRNA and Hemin results in increased expression of GCLC protein CTD PMID:16631525 and PMID:33434570 GCLC Human hemin multiple interactions EXP 6480464 [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GCLC mRNA and [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GCLC protein CTD PMID:33434570 GCLC Human Hexachloro-1,3-butadiene decreases expression ISO Gclc (Rattus norvegicus) 6480464 hexachlorobutadiene results in decreased expression of GCLC mRNA CTD PMID:21905055 GCLC Human Hexachloro-1,3-butadiene increases expression ISO Gclc (Rattus norvegicus) 6480464 hexachlorobutadiene results in increased expression of GCLC mRNA CTD PMID:21905055 GCLC Human hexadecanoic acid increases expression ISO Gclc (Rattus norvegicus) 6480464 Palmitic Acid results in increased expression of GCLC mRNA CTD PMID:28027979 GCLC Human hexadecanoic acid multiple interactions EXP 6480464 [Palmitic Acid co-treated with Oleic Acid] results in decreased expression of GCLC protein and Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of GCLC protein] CTD PMID:36905866 GCLC Human hexane increases expression EXP 6480464 n-hexane results in increased expression of GCLC mRNA CTD PMID:20566472 GCLC Human hydrogen chloride multiple interactions ISO Gclc (Mus musculus) 6480464 NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GCLC mRNA] CTD PMID:29618784 GCLC Human hydrogen chloride increases expression ISO Gclc (Mus musculus) 6480464 Hydrochloric Acid results in increased expression of GCLC mRNA CTD PMID:29618784 GCLC Human hydrogen peroxide affects expression EXP 6480464 Hydrogen Peroxide affects the expression of GCLC mRNA CTD PMID:20044591 GCLC Human hydrogen peroxide decreases expression ISO Gclc (Rattus norvegicus) 6480464 Hydrogen Peroxide results in decreased expression of GCLC mRNA and Hydrogen Peroxide results in decreased expression of GCLC protein CTD PMID:36305173 GCLC Human hydrogen peroxide multiple interactions ISO Gclc (Rattus norvegicus) 6480464 Hydrogen Peroxide affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of GCLC mRNA] more ... CTD PMID:24437944 and PMID:27028516 GCLC Human hydrogen peroxide affects expression ISO Gclc (Rattus norvegicus) 6480464 Hydrogen Peroxide affects the expression of GCLC protein CTD PMID:24437944 GCLC Human hydrogen peroxide multiple interactions EXP 6480464 4-((alpha-L-rhamnosyloxy)benzyl)isothiocyanate inhibits the reaction [Hydrogen Peroxide results in decreased expression of GCLC mRNA] more ... CTD PMID:24866057 and PMID:31521693 GCLC Human hydrogen peroxide decreases expression EXP 6480464 Hydrogen Peroxide results in decreased expression of GCLC mRNA and Hydrogen Peroxide results in decreased expression of GCLC protein CTD PMID:24866057 and PMID:31521693 GCLC Human hydrogen peroxide increases expression EXP 6480464 Hydrogen Peroxide results in increased expression of GCLC mRNA CTD PMID:12598062 more ... GCLC Human hydrogen peroxide multiple interactions ISO Gclc (Mus musculus) 6480464 GCLC protein inhibits the reaction [Hydrogen Peroxide results in decreased abundance of Glutathione] more ... CTD PMID:19914271 and PMID:31494107 GCLC Human hydrogen peroxide decreases response to substance ISO Gclc (Mus musculus) 6480464 GCLC protein results in decreased susceptibility to Hydrogen Peroxide CTD PMID:19914271 GCLC Human hydroquinone increases expression ISO Gclc (Mus musculus) 6480464 hydroquinone results in increased expression of GCLC mRNA and hydroquinone results in increased expression of GCLC protein CTD PMID:23290930 and PMID:30547568 GCLC Human hydroquinone affects methylation EXP 6480464 hydroquinone affects the methylation of GCLC promoter CTD PMID:23940045 GCLC Human hydroquinone multiple interactions EXP 6480464 [hydroquinone affects the methylation of GCLC promoter] which results in decreased abundance of 5-Methylcytosine more ... CTD PMID:23940045 and PMID:32334435 GCLC Human hydroquinone increases expression EXP 6480464 hydroquinone results in increased expression of GCLC mRNA CTD PMID:23940045 and PMID:32334435 GCLC Human hypochlorous acid multiple interactions ISO Gclc (Mus musculus) 6480464 Acetylcysteine inhibits the reaction [Hypochlorous Acid results in increased expression of GCLC mRNA] more ... CTD PMID:17980396 GCLC Human hypochlorous acid affects expression ISO Gclc (Mus musculus) 6480464 Hypochlorous Acid affects the expression of GCLC mRNA CTD PMID:18648578 GCLC Human hypochlorous acid increases expression ISO Gclc (Mus musculus) 6480464 Hypochlorous Acid results in increased expression of GCLC mRNA CTD PMID:17980396 GCLC Human ibuprofen increases expression EXP 6480464 Ibuprofen results in increased expression of GCLC mRNA CTD PMID:11909699 GCLC Human ifosfamide decreases expression EXP 6480464 Ifosfamide results in decreased expression of GCLC mRNA CTD PMID:25596134 GCLC Human indometacin multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Indomethacin results in increased expression of GCLC mRNA] more ... CTD PMID:11909699 GCLC Human indometacin multiple interactions ISO Gclc (Mus musculus) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Rosiglitazone co-treated with Indomethacin] results in increased expression of GCLC mRNA CTD PMID:33412187 GCLC Human indometacin decreases expression ISO Gclc (Rattus norvegicus) 6480464 Indomethacin results in decreased expression of GCLC mRNA CTD PMID:36868495 GCLC Human indometacin increases expression EXP 6480464 Indomethacin results in increased expression of GCLC mRNA and Indomethacin results in increased expression of GCLC protein CTD PMID:11820781 and PMID:11909699 GCLC Human iron atom increases activity ISO Gclc (Rattus norvegicus) 6480464 Iron results in increased activity of GCLC protein CTD PMID:17189828 GCLC Human iron atom multiple interactions ISO Gclc (Rattus norvegicus) 6480464 leonurine inhibits the reaction [Iron results in decreased expression of GCLC protein] CTD PMID:35247364 GCLC Human iron atom decreases expression ISO Gclc (Rattus norvegicus) 6480464 Iron results in decreased expression of GCLC protein CTD PMID:35247364 GCLC Human iron atom decreases expression EXP 6480464 Iron results in decreased expression of GCLC mRNA CTD PMID:19073151 GCLC Human iron atom multiple interactions EXP 6480464 Ursodeoxycholic Acid inhibits the reaction [Iron results in decreased expression of GCLC mRNA] CTD PMID:19073151 GCLC Human iron trichloride multiple interactions ISO Gclc (Mus musculus) 6480464 [ferric chloride co-treated with TNF protein] results in increased expression of GCLC protein CTD PMID:19900513 GCLC Human iron(0) increases activity ISO Gclc (Rattus norvegicus) 6480464 Iron results in increased activity of GCLC protein CTD PMID:17189828 GCLC Human iron(0) multiple interactions ISO Gclc (Rattus norvegicus) 6480464 leonurine inhibits the reaction [Iron results in decreased expression of GCLC protein] CTD PMID:35247364 GCLC Human iron(0) decreases expression ISO Gclc (Rattus norvegicus) 6480464 Iron results in decreased expression of GCLC protein CTD PMID:35247364 GCLC Human iron(0) multiple interactions EXP 6480464 Ursodeoxycholic Acid inhibits the reaction [Iron results in decreased expression of GCLC mRNA] CTD PMID:19073151 GCLC Human iron(0) decreases expression EXP 6480464 Iron results in decreased expression of GCLC mRNA CTD PMID:19073151 GCLC Human iron(2+) sulfate (anhydrous) multiple interactions EXP 6480464 ferrous sulfate promotes the reaction [SNCA protein results in decreased expression of GCLC protein] CTD PMID:27424009 GCLC Human iron(2+) sulfate (anhydrous) decreases expression EXP 6480464 ferrous sulfate results in decreased expression of GCLC protein CTD PMID:27424009 GCLC Human iron(III) nitrilotriacetate increases expression ISO Gclc (Mus musculus) 6480464 ferric nitrilotriacetate results in increased expression of GCLC mRNA CTD PMID:18617210 GCLC Human isoeugenol increases expression EXP 6480464 isoeugenol results in increased expression of GCLC mRNA CTD PMID:20566472 GCLC Human isoniazide increases expression ISO Gclc (Mus musculus) 6480464 Isoniazid results in increased expression of GCLC mRNA CTD PMID:33771660 GCLC Human isoniazide multiple interactions ISO Gclc (Rattus norvegicus) 6480464 chrysin inhibits the reaction [Isoniazid results in increased expression of GCLC mRNA] CTD PMID:33121995 GCLC Human isoniazide increases expression ISO Gclc (Rattus norvegicus) 6480464 Isoniazid results in increased expression of GCLC mRNA CTD PMID:33121995 GCLC Human isoniazide decreases expression ISO Gclc (Mus musculus) 6480464 Isoniazid results in decreased expression of GCLC mRNA CTD PMID:24128855 GCLC Human isoniazide multiple interactions ISO Gclc (Mus musculus) 6480464 Isoniazid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of GCLC mRNA] CTD PMID:24128855 GCLC Human isoprenaline decreases expression ISO Gclc (Mus musculus) 6480464 Isoproterenol results in decreased expression of GCLC mRNA CTD PMID:21335049 GCLC Human isorhamnetin multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein] more ... CTD PMID:24211276 GCLC Human isorhamnetin multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC mRNA and [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC protein CTD PMID:25716194 GCLC Human isorhamnetin increases expression ISO Gclc (Rattus norvegicus) 6480464 3-methylquercetin results in increased expression of GCLC mRNA and 3-methylquercetin results in increased expression of GCLC protein CTD PMID:25716194 GCLC Human isorhamnetin multiple interactions ISO Gclc (Mus musculus) 6480464 [3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein CTD PMID:24211276 GCLC Human isothiocyanate increases expression ISO Gclc (Mus musculus) 6480464 Isothiocyanates results in increased expression of GCLC protein CTD PMID:15570060 GCLC Human ivermectin decreases expression EXP 6480464 Ivermectin results in decreased expression of GCLC protein CTD PMID:32959892 GCLC Human kaempferol increases expression EXP 6480464 kaempferol results in increased expression of GCLC mRNA CTD PMID:11864778 GCLC Human kaempferol multiple interactions ISO Gclc (Mus musculus) 6480464 kaempferol affects the reaction [propacetamol affects the expression of GCLC protein] CTD PMID:29574133 GCLC Human kahweol multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [cafestol co-treated with kahweol] inhibits the reaction [ochratoxin A results in decreased expression of GCLC protein] CTD PMID:17110534 GCLC Human ketamine increases expression ISO Gclc (Rattus norvegicus) 6480464 Ketamine results in increased expression of GCLC mRNA CTD PMID:20080153 GCLC Human ketamine decreases expression ISO Gclc (Rattus norvegicus) 6480464 Ketamine results in decreased expression of GCLC mRNA and Ketamine results in decreased expression of GCLC protein CTD PMID:36305173 GCLC Human ketamine multiple interactions ISO Gclc (Rattus norvegicus) 6480464 Curcumin inhibits the reaction [Ketamine results in decreased expression of GCLC mRNA] and Curcumin inhibits the reaction [Ketamine results in decreased expression of GCLC protein] CTD PMID:36305173 GCLC Human ketoprofen increases expression EXP 6480464 Ketoprofen results in increased expression of GCLC mRNA CTD PMID:11909699 GCLC Human L-ascorbic acid multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of GCLC mRNA more ... CTD PMID:27028516 and PMID:31585129 GCLC Human L-ascorbic acid 2-phosphate multiple interactions EXP 6480464 [[ascorbate-2-phosphate co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein] co-treated with [INHBA protein binds to INHBA protein]] results in increased expression of GCLC mRNA CTD PMID:34480604 GCLC Human L-cysteine multiple interactions ISO Gclc (Rattus norvegicus) 6480464 Cysteine promotes the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine] CTD PMID:15115889 GCLC Human L-gamma-glutamyl-L-cysteine multiple interactions ISO Gclc (Rattus norvegicus) 6480464 Buthionine Sulfoximine inhibits the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine] more ... CTD PMID:15115889 GCLC Human L-gamma-glutamyl-L-cysteine increases chemical synthesis ISO Gclc (Rattus norvegicus) 6480464 GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine CTD PMID:15115889 GCLC Human L-methionine multiple interactions ISO Gclc (Mus musculus) 6480464 [Choline deficiency co-treated with Methionine deficiency] results in increased expression of GCLC mRNA and NFE2L2 affects the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of GCLC mRNA] CTD PMID:20350562 GCLC Human lanthanum trichloride multiple interactions EXP 6480464 [cerous chloride co-treated with lanthanum chloride] results in increased expression of GCLC mRNA CTD PMID:28954213 GCLC Human lanthanum trichloride increases expression ISO Gclc (Mus musculus) 6480464 lanthanum chloride results in increased expression of GCLC mRNA and lanthanum chloride results in increased expression of GCLC protein CTD PMID:24142884 GCLC Human lanthanum trichloride decreases expression ISO Gclc (Mus musculus) 6480464 lanthanum chloride results in decreased expression of GCLC protein CTD PMID:33098623 GCLC Human lead diacetate multiple interactions EXP 6480464 NFE2L2 mutant form inhibits the reaction [lead acetate results in increased expression of GCLC mRNA] CTD PMID:26498409 GCLC Human lead diacetate increases expression EXP 6480464 lead acetate results in increased expression of GCLC mRNA CTD PMID:26498409 and PMID:38568856 GCLC Human lead(II) chloride increases expression EXP 6480464 lead chloride results in increased expression of GCLC mRNA CTD PMID:18654764 GCLC Human lead(II) chloride decreases expression EXP 6480464 lead chloride results in decreased expression of GCLC protein CTD PMID:30359721 GCLC Human lead(II) chloride multiple interactions EXP 6480464 [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of GCLC mRNA CTD PMID:18654764 GCLC Human leflunomide increases expression ISO Gclc (Rattus norvegicus) 6480464 leflunomide results in increased expression of GCLC mRNA CTD PMID:24136188 GCLC Human Leonurine multiple interactions ISO Gclc (Rattus norvegicus) 6480464 leonurine inhibits the reaction [Iron results in decreased expression of GCLC protein] CTD PMID:35247364 GCLC Human levofloxacin decreases expression ISO Gclc (Rattus norvegicus) 6480464 Levofloxacin results in decreased expression of GCLC mRNA CTD PMID:24136188 GCLC Human linalool increases expression EXP 6480464 linalool results in increased expression of GCLC mRNA CTD PMID:20491607 GCLC Human lipoic acid increases expression EXP 6480464 Thioctic Acid results in increased expression of GCLC mRNA CTD PMID:16249512 more ... GCLC Human lipoic acid multiple interactions ISO Gclc (Mus musculus) 6480464 Thioctic Acid inhibits the reaction [Silicon results in decreased expression of GCLC protein] CTD PMID:34252510 GCLC Human lipoic acid multiple interactions EXP 6480464 Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLC mRNA] and Thioctic Acid results in increased expression of and results in increased activity of GCLC protein CTD PMID:26365678 GCLC Human lipoic acid multiple interactions ISO Gclc (Rattus norvegicus) 6480464 Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GCLC protein] more ... CTD PMID:27298056 and PMID:32061141 GCLC Human lipopolysaccharide multiple interactions ISO Gclc (Mus musculus) 6480464 8-oxoberberine promotes the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of GCLC mRNA] more ... CTD PMID:35691465 GCLC Human liquiritigenin increases expression ISO Gclc (Rattus norvegicus) 6480464 liquiritigenin results in increased expression of GCLC protein CTD PMID:29908794 GCLC Human liquiritigenin multiple interactions ISO Gclc (Rattus norvegicus) 6480464 liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GCLC mRNA] CTD PMID:29908794 GCLC Human liquiritin increases expression ISO Gclc (Rattus norvegicus) 6480464 liquiritin results in increased expression of GCLC protein CTD PMID:29908794 GCLC Human liquiritin multiple interactions ISO Gclc (Rattus norvegicus) 6480464 liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GCLC mRNA] CTD PMID:29908794 GCLC Human lithocholic acid multiple interactions ISO Gclc (Mus musculus) 6480464 [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA more ... CTD PMID:17724089 more ... GCLC Human lithocholic acid decreases expression ISO Gclc (Mus musculus) 6480464 Lithocholic Acid results in decreased expression of GCLC mRNA CTD PMID:29794447 GCLC Human lithocholic acid increases expression EXP 6480464 Lithocholic Acid results in increased expression of GCLC protein CTD PMID:17724089 GCLC Human lithocholic acid multiple interactions EXP 6480464 [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA more ... CTD PMID:17724089 and PMID:20146260 GCLC Human lithocholic acid affects expression EXP 6480464 Lithocholic Acid affects the expression of GCLC mRNA and Lithocholic Acid affects the expression of GCLC protein CTD PMID:20146260 GCLC Human lithocholic acid increases expression ISO Gclc (Mus musculus) 6480464 Lithocholic Acid results in increased expression of GCLC mRNA and Lithocholic Acid results in increased expression of GCLC protein CTD PMID:20977460 GCLC Human luteolin increases expression ISO Gclc (Rattus norvegicus) 6480464 Luteolin results in increased expression of GCLC mRNA and Luteolin results in increased expression of GCLC protein CTD PMID:22864849 GCLC Human luteolin multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [Luteolin results in increased expression of GCLC mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide CTD PMID:22864849 GCLC Human LY294002 multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cinnamaldehyde results in increased expression of GCLC protein] more ... CTD PMID:19073151 more ... GCLC Human LY294002 multiple interactions ISO Gclc (Mus musculus) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA]] CTD PMID:25895139 GCLC Human LY294002 multiple interactions ISO Gclc (Rattus norvegicus) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of GCLC protein] and 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Plant Extracts results in increased expression of GCLC mRNA] CTD PMID:20399244 and PMID:25773745 GCLC Human LY294002 decreases expression EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of GCLC mRNA CTD PMID:19073151 GCLC Human lycopene multiple interactions ISO Gclc (Mus musculus) 6480464 Lycopene inhibits the reaction [Atrazine results in increased expression of GCLC mRNA] and Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of GCLC mRNA] CTD PMID:35917956 more ... GCLC Human maneb increases expression EXP 6480464 [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of GCLC mRNA CTD PMID:21402726 GCLC Human maneb increases activity ISO Gclc (Rattus norvegicus) 6480464 Maneb results in increased activity of GCLC protein CTD PMID:15527874 GCLC Human melatonin multiple interactions ISO Gclc (Mus musculus) 6480464 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]] more ... CTD PMID:25550330 GCLC Human meloxicam multiple interactions EXP 6480464 meloxicam inhibits the reaction [Paraquat results in decreased expression of GCLC protein] CTD PMID:20851755 GCLC Human menadione increases activity EXP 6480464 Vitamin K 3 results in increased activity of GCLC protein CTD PMID:11972604 GCLC Human menadione increases expression EXP 6480464 Vitamin K 3 results in increased expression of GCLC mRNA CTD PMID:11972604 and PMID:23410634 GCLC Human menadione increases expression ISO Gclc (Mus musculus) 6480464 Vitamin K 3 results in increased expression of GCLC mRNA CTD PMID:25270620 GCLC Human menadione multiple interactions EXP 6480464 Dactinomycin inhibits the reaction [Vitamin K 3 results in increased expression of GCLC mRNA] CTD PMID:11972604 GCLC Human mercury atom increases expression EXP 6480464 Mercury results in increased expression of GCLC mRNA CTD PMID:17547211 GCLC Human mercury atom multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC mRNA more ... CTD PMID:27837179 GCLC Human mercury atom multiple interactions EXP 6480464 [Mercuric Chloride results in increased abundance of Mercury] which results in decreased expression of GCLC protein and GCLC gene polymorphism promotes the reaction [GSTP1 gene polymorphism affects the abundance of Mercury] CTD PMID:19515364 and PMID:30359721 GCLC Human mercury atom affects response to substance EXP 6480464 GCLC gene SNP affects the susceptibility to Mercury CTD PMID:22236634 GCLC Human mercury dibromide increases expression EXP 6480464 mercuric bromide results in increased expression of GCLC mRNA CTD PMID:26272509 GCLC Human mercury dibromide multiple interactions EXP 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLC mRNA CTD PMID:27188386 GCLC Human mercury dichloride decreases response to substance EXP 6480464 GCLC protein results in decreased susceptibility to Mercuric Chloride CTD PMID:24118919 GCLC Human mercury dichloride multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC mRNA more ... CTD PMID:27837179 GCLC Human mercury dichloride multiple interactions EXP 6480464 [Mercuric Chloride results in increased abundance of Mercury] which results in decreased expression of GCLC protein CTD PMID:30359721 GCLC Human mercury dichloride increases expression EXP 6480464 Mercuric Chloride results in increased expression of GCLC mRNA CTD PMID:24118919 and PMID:38568856 GCLC Human mercury(0) increases expression EXP 6480464 Mercury results in increased expression of GCLC mRNA CTD PMID:17547211 GCLC Human mercury(0) multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC mRNA more ... CTD PMID:27837179 GCLC Human mercury(0) multiple interactions EXP 6480464 [Mercuric Chloride results in increased abundance of Mercury] which results in decreased expression of GCLC protein and GCLC gene polymorphism promotes the reaction [GSTP1 gene polymorphism affects the abundance of Mercury] CTD PMID:19515364 and PMID:30359721 GCLC Human mercury(0) affects response to substance EXP 6480464 GCLC gene SNP affects the susceptibility to Mercury CTD PMID:22236634 GCLC Human mesalamine multiple interactions EXP 6480464 [IL1A protein co-treated with TNF protein co-treated with IFNG protein co-treated with Mesalamine] results in increased expression of GCLC mRNA CTD PMID:27818126 GCLC Human metformin increases expression ISO Gclc (Rattus norvegicus) 6480464 Metformin results in increased expression of GCLC mRNA CTD PMID:25596134 GCLC Human methapyrilene increases expression ISO Gclc (Rattus norvegicus) 6480464 Methapyrilene results in increased expression of GCLC mRNA and Methapyrilene results in increased expression of GCLC protein CTD PMID:15890375 more ... GCLC Human methimazole increases expression EXP 6480464 Methimazole results in increased expression of GCLC mRNA CTD PMID:20144635 GCLC Human methimazole increases expression ISO Gclc (Rattus norvegicus) 6480464 Methimazole results in increased expression of GCLC mRNA CTD PMID:30047161 GCLC Human methotrexate affects expression ISO Gclc (Mus musculus) 6480464 Methotrexate affects the expression of GCLC mRNA CTD PMID:18502557 GCLC Human methoxychlor multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [Genistein co-treated with Methoxychlor] results in increased expression of GCLC mRNA CTD PMID:21782745 GCLC Human methoxychlor increases expression ISO Gclc (Rattus norvegicus) 6480464 Methoxychlor results in increased expression of GCLC mRNA CTD PMID:21782745 GCLC Human methyl non-2-ynoate increases expression EXP 6480464 2-nonynoic acid methyl ester results in increased expression of GCLC mRNA CTD PMID:20491607 GCLC Human methyl salicylate increases expression EXP 6480464 methyl salicylate results in increased expression of GCLC mRNA CTD PMID:20566472 GCLC Human methylene blue increases expression ISO Gclc (Mus musculus) 6480464 Methylene Blue results in increased expression of GCLC mRNA CTD PMID:24556215 GCLC Human methylene blue multiple interactions ISO Gclc (Mus musculus) 6480464 [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLC mRNA and NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of GCLC mRNA] CTD PMID:24556215 GCLC Human methylisothiazolinone increases expression EXP 6480464 2-methyl-4-isothiazolin-3-one results in increased expression of GCLC mRNA CTD PMID:30806763 GCLC Human methylmercury chloride increases expression ISO Gclc (Mus musculus) 6480464 methylmercuric chloride results in increased expression of GCLC mRNA CTD PMID:20061341 GCLC Human methylmercury chloride decreases expression ISO Gclc (Rattus norvegicus) 6480464 methylmercuric chloride results in decreased expression of GCLC protein CTD PMID:32061141 GCLC Human methylmercury chloride multiple interactions ISO Gclc (Rattus norvegicus) 6480464 Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GCLC protein] more ... CTD PMID:27298056 and PMID:32061141 GCLC Human methylmercury chloride increases expression ISO Gclc (Rattus norvegicus) 6480464 methylmercuric chloride results in increased expression of GCLC mRNA and methylmercuric chloride results in increased expression of GCLC protein CTD PMID:27298056 and PMID:32061141 GCLC Human methylmercury chloride increases expression EXP 6480464 methylmercuric chloride results in increased expression of GCLC mRNA CTD PMID:24118919 and PMID:28001369 GCLC Human methylmercury chloride decreases response to substance EXP 6480464 GCLC protein results in decreased susceptibility to methylmercuric chloride CTD PMID:24118919 GCLC Human Methysticin increases expression ISO Gclc (Mus musculus) 6480464 methysticin results in increased expression of GCLC mRNA CTD PMID:28448946 GCLC Human microcystin increases expression ISO Gclc (Rattus norvegicus) 6480464 Microcystins analog results in increased expression of GCLC mRNA CTD PMID:24964298 GCLC Human microcystin multiple interactions ISO Gclc (Rattus norvegicus) 6480464 Buthionine Sulfoximine inhibits the reaction [Microcystins analog results in increased expression of GCLC mRNA] CTD PMID:24964298 GCLC Human microcystin-LR increases expression ISO Gclc (Mus musculus) 6480464 cyanoginosin LR results in increased expression of GCLC mRNA CTD PMID:17654400 GCLC Human microcystin-LR decreases expression EXP 6480464 cyanoginosin LR results in decreased expression of GCLC mRNA CTD PMID:30940545 GCLC Human microcystin-LR multiple interactions EXP 6480464 cyanoginosin LR results in decreased expression of and results in increased phosphorylation of GCLC protein and GCLC protein inhibits the reaction [cyanoginosin LR results in decreased activity of CAT protein] CTD PMID:30940545 GCLC Human mifepristone multiple interactions ISO Gclc (Mus musculus) 6480464 Acetaminophen promotes the reaction [Mifepristone results in increased activity of [GCLC protein binds to GCLM protein]] and Mifepristone results in increased activity of [GCLC protein binds to GCLM protein] CTD PMID:16840778 GCLC Human mifepristone increases expression ISO Gclc (Mus musculus) 6480464 Mifepristone results in increased expression of GCLC protein CTD PMID:16840778 GCLC Human miquelianin multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC mRNA and [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC protein CTD PMID:25716194 GCLC Human MK 571 multiple interactions EXP 6480464 [verlukast binds to and results in decreased activity of ABCC1 protein] inhibits the reaction [15-deoxy-delta(12 and 14)-prostaglandin J2 results in increased expression of GCLC protein] CTD PMID:21728338 GCLC Human mono(2-ethylhexyl) phthalate increases expression ISO Gclc (Mus musculus) 6480464 mono-(2-ethylhexyl)phthalate results in increased expression of GCLC mRNA CTD PMID:34863575 GCLC Human monocrotaline decreases expression ISO Gclc (Rattus norvegicus) 6480464 Monocrotaline results in decreased expression of GCLC mRNA CTD PMID:29908794 GCLC Human monocrotaline multiple interactions ISO Gclc (Rattus norvegicus) 6480464 liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GCLC mRNA] and liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GCLC mRNA] CTD PMID:29908794 GCLC Human N,N-diethyl-m-toluamide multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of GCLC mRNA CTD PMID:28659758 GCLC Human N,N-dimethylformamide increases expression ISO Gclc (Mus musculus) 6480464 Dimethylformamide results in increased expression of GCLC protein CTD PMID:37995826 GCLC Human N,N-dimethylformamide multiple interactions ISO Gclc (Mus musculus) 6480464 allyl methyl disulfide inhibits the reaction [Dimethylformamide results in increased expression of GCLC protein] CTD PMID:37995826 GCLC Human N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide multiple interactions EXP 6480464 N-(3 and 5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Copper results in increased expression of GCLC mRNA] CTD PMID:19747488 GCLC Human N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [15-deoxy-delta(12 more ... CTD PMID:11820781 more ... GCLC Human N-acetyl-L-cysteine multiple interactions ISO Gclc (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [decamethrin results in increased expression of GCLC mRNA] and Acetylcysteine inhibits the reaction [decamethrin results in increased expression of GCLC protein] CTD PMID:17540521 GCLC Human N-acetyl-L-cysteine multiple interactions ISO Gclc (Mus musculus) 6480464 Acetylcysteine inhibits the reaction [2' more ... CTD PMID:17980396 more ... GCLC Human N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal increases expression EXP 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GCLC mRNA and benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GCLC protein CTD PMID:30186748 and PMID:33434570 GCLC Human N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions EXP 6480464 [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GCLC mRNA more ... CTD PMID:25263748 more ... GCLC Human N-methyl-4-phenylpyridinium multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC mRNA and [1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC protein CTD PMID:32763437 GCLC Human N-methyl-4-phenylpyridinium multiple interactions ISO Gclc (Mus musculus) 6480464 [1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC mRNA more ... CTD PMID:32763437 GCLC Human N-methylformamide affects expression ISO Gclc (Mus musculus) 6480464 methylformamide affects the expression of GCLC mRNA and methylformamide analog affects the expression of GCLC mRNA CTD PMID:17040096 GCLC Human N-methylnicotinate multiple interactions EXP 6480464 trigonelline inhibits the reaction [Pyocyanine results in increased expression of GCLC mRNA] CTD PMID:24015256 GCLC Human N-nitrosodiethylamine multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GCLC mRNA more ... CTD PMID:14656948 more ... GCLC Human N-nitrosodiethylamine increases expression ISO Gclc (Mus musculus) 6480464 Diethylnitrosamine results in increased expression of GCLC mRNA CTD PMID:35523338 GCLC Human N-nitrosodiethylamine increases expression ISO Gclc (Rattus norvegicus) 6480464 Diethylnitrosamine results in increased expression of GCLC mRNA CTD PMID:19638242 GCLC Human N-nitrosodimethylamine increases expression EXP 6480464 Dimethylnitrosamine results in increased expression of GCLC mRNA CTD PMID:17547211 GCLC Human N-nitrosodimethylamine decreases expression ISO Gclc (Rattus norvegicus) 6480464 Dimethylnitrosamine results in decreased expression of GCLC protein CTD PMID:23485615 GCLC Human N-nitrosodimethylamine multiple interactions ISO Gclc (Rattus norvegicus) 6480464 Plant Extracts inhibits the reaction [Dimethylnitrosamine results in decreased expression of GCLC protein] CTD PMID:23485615 GCLC Human N-nitrosodimethylamine increases expression ISO Gclc (Rattus norvegicus) 6480464 Dimethylnitrosamine results in increased expression of GCLC mRNA CTD PMID:14600272 and PMID:15890375 GCLC Human N-tosyl-L-phenylalanyl chloromethyl ketone increases expression EXP 6480464 Tosylphenylalanyl Chloromethyl Ketone results in increased expression of GCLC mRNA CTD PMID:22851183 GCLC Human N-tosyl-L-phenylalanyl chloromethyl ketone increases expression ISO Gclc (Mus musculus) 6480464 Tosylphenylalanyl Chloromethyl Ketone results in increased expression of GCLC mRNA CTD PMID:22851183 GCLC Human naphthalene multiple interactions ISO Gclc (Mus musculus) 6480464 Buthionine Sulfoximine inhibits the reaction [GCLC protein results in decreased susceptibility to naphthalene] more ... CTD PMID:10900227 and PMID:12805647 GCLC Human naphthalene decreases expression ISO Gclc (Mus musculus) 6480464 naphthalene results in decreased expression of GCLC mRNA CTD PMID:31020322 GCLC Human naphthalene increases expression ISO Gclc (Rattus norvegicus) 6480464 naphthalene analog results in increased expression of GCLC mRNA and naphthalene results in increased expression of GCLC mRNA CTD PMID:24563378 and PMID:24976557 GCLC Human naphthalene increases activity ISO Gclc (Mus musculus) 6480464 naphthalene results in increased activity of GCLC protein CTD PMID:10900227 GCLC Human naphthalene decreases response to substance ISO Gclc (Mus musculus) 6480464 GCLC protein results in decreased susceptibility to naphthalene CTD PMID:10900227 and PMID:12805647 GCLC Human naphthalene-1,2-diol increases expression EXP 6480464 1 and 2-dihydroxynaphthalene analog results in increased expression of GCLC mRNA CTD PMID:25807370 GCLC Human naproxen increases expression EXP 6480464 Naproxen results in increased expression of GCLC mRNA CTD PMID:11909699 GCLC Human naringin multiple interactions ISO Gclc (Rattus norvegicus) 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of GCLC protein] more ... CTD PMID:22871521 and PMID:25773745 GCLC Human naringin increases expression ISO Gclc (Rattus norvegicus) 6480464 naringin results in increased expression of GCLC mRNA and naringin results in increased expression of GCLC protein CTD PMID:22871521 and PMID:25773745 GCLC Human nefazodone increases expression ISO Gclc (Rattus norvegicus) 6480464 nefazodone results in increased expression of GCLC mRNA CTD PMID:24136188 GCLC Human neoastilbin multiple interactions EXP 6480464 astilbin inhibits the reaction [Cisplatin results in decreased expression of GCLC mRNA] CTD PMID:29471006 GCLC Human nickel dichloride affects expression ISO Gclc (Rattus norvegicus) 6480464 nickel chloride affects the expression of GCLC mRNA CTD PMID:22110744 GCLC Human nickel dichloride increases expression EXP 6480464 nickel chloride results in increased expression of GCLC mRNA CTD PMID:17547211 and PMID:21111804 GCLC Human nickel sulfate increases expression ISO Gclc (Mus musculus) 6480464 nickel sulfate results in increased expression of GCLC mRNA CTD PMID:16100012 GCLC Human nickel sulfate increases expression EXP 6480464 nickel sulfate results in increased expression of GCLC mRNA CTD PMID:20491607 and PMID:20566472 GCLC Human nicotinamide multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC mRNA more ... CTD PMID:21439372 GCLC Human nicotine multiple interactions ISO Gclc (Mus musculus) 6480464 [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 GCLC Human nimesulide increases expression ISO Gclc (Rattus norvegicus) 6480464 nimesulide results in increased expression of GCLC mRNA CTD PMID:24136188 GCLC Human nimustine increases expression EXP 6480464 Nimustine results in increased expression of GCLC mRNA CTD PMID:9393752 GCLC Human nitisinone multiple interactions ISO Gclc (Mus musculus) 6480464 [nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLC mRNA CTD PMID:12899938 GCLC Human nitric oxide decreases expression ISO Gclc (Rattus norvegicus) 6480464 Nitric Oxide deficiency results in decreased expression of GCLC mRNA and Nitric Oxide deficiency results in decreased expression of GCLC protein CTD PMID:19631198 GCLC Human nitrofurantoin increases expression EXP 6480464 Nitrofurantoin results in increased expression of GCLC protein CTD PMID:34021431 GCLC Human nitrofurantoin multiple interactions EXP 6480464 NFE2L2 protein affects the reaction [Nitrofurantoin results in increased expression of GCLC protein] and POR protein affects the reaction [Nitrofurantoin results in increased expression of GCLC protein] CTD PMID:34021431 GCLC Human Nodularin affects expression EXP 6480464 nodularin affects the expression of GCLC mRNA CTD PMID:30562542 GCLC Human Nonidet P-40 decreases expression EXP 6480464 Nonidet P-40 results in decreased expression of GCLC mRNA CTD PMID:26552463 GCLC Human norswertianolin increases expression ISO Gclc (Rattus norvegicus) 6480464 norswertianolin results in increased expression of GCLC mRNA and norswertianolin results in increased expression of GCLC protein CTD PMID:30800665 GCLC Human notoginsenoside R1 multiple interactions ISO Gclc (Rattus norvegicus) 6480464 Cycloheximide inhibits the reaction [notoginsenoside R1 results in increased expression of GCLC protein] more ... CTD PMID:24437944 GCLC Human notoginsenoside R1 increases expression ISO Gclc (Rattus norvegicus) 6480464 notoginsenoside R1 results in increased expression of GCLC protein CTD PMID:24437944 GCLC Human Nutlin-3 multiple interactions EXP 6480464 [Dactinomycin co-treated with nutlin 3] results in increased secretion of GCLC protein CTD PMID:38460933 GCLC Human ochratoxin A multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [cafestol co-treated with kahweol] inhibits the reaction [ochratoxin A results in decreased expression of GCLC protein] CTD PMID:17110534 GCLC Human ochratoxin A increases expression EXP 6480464 ochratoxin A results in increased expression of GCLC mRNA CTD PMID:30291945 and PMID:32905824 GCLC Human ochratoxin A multiple interactions EXP 6480464 AHR protein affects the reaction [ochratoxin A results in increased expression of GCLC mRNA] and NR1I2 protein affects the reaction [ochratoxin A results in increased expression of GCLC mRNA] CTD PMID:30291945 GCLC Human ochratoxin A increases expression ISO Gclc (Mus musculus) 6480464 ochratoxin A results in increased expression of GCLC mRNA CTD PMID:30291945 GCLC Human ochratoxin A affects expression ISO Gclc (Rattus norvegicus) 6480464 ochratoxin A affects the expression of GCLC mRNA CTD PMID:32468156 GCLC Human ochratoxin A decreases expression ISO Gclc (Rattus norvegicus) 6480464 ochratoxin A results in decreased expression of GCLC mRNA and ochratoxin A results in decreased expression of GCLC protein CTD PMID:16251485 more ... GCLC Human olanzapine increases expression ISO Gclc (Mus musculus) 6480464 Olanzapine results in increased expression of GCLC mRNA CTD PMID:37005277 GCLC Human oleanolic acid increases expression ISO Gclc (Rattus norvegicus) 6480464 Oleanolic Acid results in increased expression of GCLC mRNA CTD PMID:18706400 GCLC Human oleanolic acid increases expression ISO Gclc (Mus musculus) 6480464 Oleanolic Acid results in increased expression of GCLC mRNA and Oleanolic Acid results in increased expression of GCLC protein CTD PMID:18706400 more ... GCLC Human oleic acid multiple interactions EXP 6480464 [Palmitic Acid co-treated with Oleic Acid] results in decreased expression of GCLC protein and Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of GCLC protein] CTD PMID:36905866 GCLC Human oxaliplatin multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of GCLC mRNA and [Topotecan co-treated with oxaliplatin] results in decreased expression of GCLC mRNA CTD PMID:25729387 GCLC Human oxaliplatin decreases expression ISO Gclc (Rattus norvegicus) 6480464 oxaliplatin results in decreased expression of GCLC mRNA CTD PMID:25729387 GCLC Human oxidopamine multiple interactions EXP 6480464 salvin inhibits the reaction [Oxidopamine results in decreased expression of GCLC protein] CTD PMID:25446857 GCLC Human oxidopamine multiple interactions ISO Gclc (Rattus norvegicus) 6480464 salvin inhibits the reaction [Oxidopamine results in decreased expression of GCLC protein] CTD PMID:25446857 GCLC Human oxidopamine decreases expression ISO Gclc (Rattus norvegicus) 6480464 Oxidopamine results in decreased expression of GCLC protein CTD PMID:25446857 GCLC Human oxidopamine decreases expression EXP 6480464 Oxidopamine results in decreased expression of GCLC protein CTD PMID:25446857 GCLC Human oxidopamine increases expression ISO Gclc (Rattus norvegicus) 6480464 Oxidopamine results in increased expression of GCLC mRNA and Oxidopamine results in increased expression of GCLC protein CTD PMID:21397656 GCLC Human ozone multiple interactions ISO Gclc (Mus musculus) 6480464 [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of GCLC mRNA more ... CTD PMID:17460151 more ... GCLC Human ozone increases expression ISO Gclc (Mus musculus) 6480464 Ozone results in increased expression of GCLC mRNA CTD PMID:17095637 GCLC Human p-chloromercuribenzoic acid increases expression EXP 6480464 p-Chloromercuribenzoic Acid results in increased expression of GCLC mRNA CTD PMID:26272509 GCLC Human p-chloromercuribenzoic acid multiple interactions EXP 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLC mRNA CTD PMID:27188386 GCLC Human para-Cresidine increases expression EXP 6480464 cresidine results in increased expression of GCLC mRNA CTD PMID:26198647 GCLC Human paracetamol multiple interactions EXP 6480464 Chlorogenic Acid promotes the reaction [Acetaminophen results in increased expression of GCLC mRNA] more ... CTD PMID:25881548 and PMID:29136249 GCLC Human paracetamol decreases expression ISO Gclc (Mus musculus) 6480464 Acetaminophen results in decreased expression of GCLC mRNA CTD PMID:25818464 and PMID:29355602 GCLC Human paracetamol decreases response to substance ISO Gclc (Mus musculus) 6480464 GCLC protein results in decreased susceptibility to Acetaminophen CTD PMID:18642143 and PMID:24661219 GCLC Human paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of GCLC mRNA and Acetaminophen results in decreased expression of GCLC protein CTD PMID:27761495 and PMID:37792503 GCLC Human paracetamol decreases expression ISO Gclc (Rattus norvegicus) 6480464 Acetaminophen results in decreased expression of GCLC mRNA CTD PMID:26767949 GCLC Human paracetamol increases expression ISO Gclc (Mus musculus) 6480464 Acetaminophen results in increased expression of GCLC mRNA and Acetaminophen results in increased expression of GCLC protein CTD PMID:10915739 more ... GCLC Human paracetamol increases expression ISO Gclc (Rattus norvegicus) 6480464 Acetaminophen results in increased expression of GCLC mRNA CTD PMID:11245408 more ... GCLC Human paracetamol affects expression ISO Gclc (Mus musculus) 6480464 Acetaminophen affects the expression of GCLC mRNA CTD PMID:15606129 more ... GCLC Human paracetamol affects response to substance ISO Gclc (Rattus norvegicus) 6480464 GCLC protein affects the susceptibility to Acetaminophen CTD PMID:17573345 GCLC Human paracetamol decreases activity ISO Gclc (Mus musculus) 6480464 Acetaminophen results in decreased activity of GCLC protein CTD PMID:10915739 GCLC Human paracetamol multiple interactions ISO Gclc (Mus musculus) 6480464 [Acetaminophen co-treated with amlexanox co-treated with dorsomorphin] affects the expression of GCLC mRNA more ... CTD PMID:15122755 more ... GCLC Human paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of GCLC mRNA CTD PMID:21420995 more ... GCLC Human paraquat increases expression ISO Gclc (Mus musculus) 6480464 Paraquat results in increased expression of GCLC mRNA CTD PMID:17215068 and PMID:31216030 GCLC Human paraquat multiple interactions ISO Gclc (Mus musculus) 6480464 SIRT6 promotes the reaction [Paraquat results in increased expression of GCLC mRNA] CTD PMID:31216030 GCLC Human paraquat increases expression ISO Gclc (Rattus norvegicus) 6480464 Paraquat results in increased expression of GCLC mRNA CTD PMID:26598004 more ... GCLC Human paraquat decreases expression EXP 6480464 Paraquat results in decreased expression of GCLC mRNA and Paraquat results in decreased expression of GCLC protein CTD PMID:20851755 and PMID:24866057 GCLC Human paraquat multiple interactions EXP 6480464 [alpha-Tocopherol co-treated with Paraquat] results in increased expression of GCLC mRNA more ... CTD PMID:20851755 more ... GCLC Human paraquat affects expression ISO Gclc (Rattus norvegicus) 6480464 Paraquat affects the expression of GCLC mRNA CTD PMID:16854511 GCLC Human perfluorobutyric acid increases expression ISO Gclc (Mus musculus) 6480464 perfluorobutyric acid results in increased expression of GCLC mRNA CTD PMID:34474067 GCLC Human perfluorohexanesulfonic acid multiple interactions ISO Gclc (Mus musculus) 6480464 [perfluorohexanesulfonic acid co-treated with Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of GCLC mRNA CTD PMID:32991729 GCLC Human perfluorononanoic acid decreases expression ISO Gclc (Mus musculus) 6480464 perfluoro-n-nonanoic acid results in decreased expression of GCLC mRNA CTD PMID:23567314 GCLC Human perfluorooctane-1-sulfonic acid increases expression ISO Gclc (Mus musculus) 6480464 perfluorooctane sulfonic acid results in increased expression of GCLC mRNA CTD PMID:26548598 GCLC Human perfluorooctane-1-sulfonic acid multiple interactions ISO Gclc (Mus musculus) 6480464 [Dietary Fats co-treated with perfluorooctane sulfonic acid] results in increased expression of GCLC mRNA more ... CTD PMID:32979393 more ... GCLC Human perfluorooctanoic acid decreases expression ISO Gclc (Mus musculus) 6480464 perfluorooctanoic acid results in decreased expression of GCLC mRNA CTD PMID:23567314 and PMID:30547568 GCLC Human perfluoroundecanoic acid decreases expression ISO Gclc (Mus musculus) 6480464 perfluoroundecanoic acid results in decreased expression of GCLC mRNA CTD PMID:23567314 GCLC Human permethrin multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of GCLC mRNA CTD PMID:28659758 GCLC Human phenethyl caffeate multiple interactions ISO Gclc (Mus musculus) 6480464 caffeic acid phenethyl ester inhibits the reaction [Bleomycin results in decreased expression of GCLC protein] CTD PMID:23570914 GCLC Human phenethyl isothiocyanate increases expression EXP 6480464 phenethyl isothiocyanate results in increased expression of GCLC mRNA CTD PMID:20442190 GCLC Human phenobarbital decreases expression ISO Gclc (Mus musculus) 6480464 Phenobarbital results in decreased expression of GCLC mRNA CTD PMID:19270015 GCLC Human phenobarbital decreases expression ISO Gclc (Rattus norvegicus) 6480464 Phenobarbital results in decreased expression of GCLC mRNA CTD PMID:19162173 GCLC Human phenol increases expression EXP 6480464 Phenol results in increased expression of GCLC mRNA CTD PMID:26198647 GCLC Human phenylmercury acetate increases expression EXP 6480464 Phenylmercuric Acetate results in increased expression of GCLC mRNA CTD PMID:26272509 GCLC Human phenylmercury acetate multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLC mRNA CTD PMID:27188386 GCLC Human phlorizin decreases expression ISO Gclc (Mus musculus) 6480464 Phlorhizin results in decreased expression of GCLC mRNA CTD PMID:22538082 GCLC Human phloroglucinol increases expression ISO Gclc (Mus musculus) 6480464 Phloroglucinol results in increased expression of GCLC protein CTD PMID:20188716 GCLC Human phorbol 13-acetate 12-myristate multiple interactions EXP 6480464 [Tetradecanoylphorbol Acetate co-treated with Rosuvastatin Calcium] results in increased expression of GCLC mRNA CTD PMID:18154958 GCLC Human phorbol 13-acetate 12-myristate increases expression EXP 6480464 Tetradecanoylphorbol Acetate results in increased expression of GCLC mRNA CTD PMID:18154958 and PMID:26198647 GCLC Human phorbol 13-acetate 12-myristate increases expression ISO Gclc (Mus musculus) 6480464 Tetradecanoylphorbol Acetate results in increased expression of GCLC mRNA CTD PMID:17200146 GCLC Human phosgene affects expression ISO Gclc (Mus musculus) 6480464 Phosgene affects the expression of GCLC mRNA CTD PMID:16300373 GCLC Human piperonyl butoxide increases expression ISO Gclc (Rattus norvegicus) 6480464 Piperonyl Butoxide results in increased expression of GCLC mRNA CTD PMID:15890375 GCLC Human pirinixic acid increases expression ISO Gclc (Rattus norvegicus) 6480464 pirinixic acid results in increased expression of GCLC mRNA CTD PMID:15890375 and PMID:19162173 GCLC Human pirinixic acid increases expression ISO Gclc (Mus musculus) 6480464 pirinixic acid results in increased expression of GCLC mRNA CTD PMID:17426115 GCLC Human pirinixic acid decreases expression ISO Gclc (Mus musculus) 6480464 pirinixic acid results in decreased expression of GCLC mRNA CTD PMID:18445702 GCLC Human Polpunonic acid increases expression EXP 6480464 maytenonic acid results in increased expression of GCLC mRNA CTD PMID:27751938 GCLC Human Polpunonic acid increases expression ISO Gclc (Mus musculus) 6480464 maytenonic acid results in increased expression of GCLC mRNA CTD PMID:27751938 GCLC Human potassium chloride multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [Desoxycorticosterone Acetate co-treated with Sodium Chloride and Dietary co-treated with Potassium Chloride] results in decreased expression of GCLC mRNA CTD PMID:22228705 GCLC Human potassium chromate multiple interactions ISO Gclc (Mus musculus) 6480464 [Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of GCLC mRNA] CTD PMID:14625279 GCLC Human potassium dichromate multiple interactions ISO Gclc (Mus musculus) 6480464 [Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of GCLC mRNA] CTD PMID:14625279 GCLC Human pravastatin decreases expression ISO Gclc (Rattus norvegicus) 6480464 Pravastatin results in decreased expression of GCLC mRNA CTD PMID:27225895 GCLC Human pravastatin increases expression ISO Gclc (Mus musculus) 6480464 Pravastatin results in increased expression of GCLC mRNA CTD PMID:27225895 GCLC Human prazosin multiple interactions ISO Gclc (Mus musculus) 6480464 Prazosin inhibits the reaction [Acetaminophen results in increased expression of GCLC mRNA] CTD PMID:18071297 GCLC Human pregnenolone 16alpha-carbonitrile increases expression ISO Gclc (Rattus norvegicus) 6480464 Pregnenolone Carbonitrile results in increased expression of GCLC mRNA CTD PMID:19162173 GCLC Human pregnenolone 16alpha-carbonitrile decreases expression ISO Gclc (Mus musculus) 6480464 Pregnenolone Carbonitrile results in decreased expression of GCLC mRNA CTD PMID:28903501 GCLC Human progesterone decreases expression ISO Gclc (Mus musculus) 6480464 Progesterone results in decreased expression of GCLC mRNA CTD PMID:22238285 GCLC Human propacetamol multiple interactions ISO Gclc (Mus musculus) 6480464 kaempferol affects the reaction [propacetamol affects the expression of GCLC protein] CTD PMID:29574133 GCLC Human propacetamol affects expression ISO Gclc (Mus musculus) 6480464 propacetamol affects the expression of GCLC protein CTD PMID:29574133 GCLC Human propan-2-ol increases expression EXP 6480464 2-Propanol results in increased expression of GCLC mRNA CTD PMID:20566472 GCLC Human propanal decreases expression EXP 6480464 propionaldehyde results in decreased expression of GCLC mRNA CTD PMID:26079696 GCLC Human prostaglandin J2 increases expression ISO Gclc (Rattus norvegicus) 6480464 9-deoxy-delta-9-prostaglandin D2 results in increased expression of GCLC mRNA and 9-deoxy-delta-9-prostaglandin D2 results in increased expression of GCLC protein CTD PMID:18332871 GCLC Human puerarin multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC mRNA and [1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC protein CTD PMID:32763437 GCLC Human puerarin multiple interactions ISO Gclc (Mus musculus) 6480464 [1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC mRNA more ... CTD PMID:32763437 GCLC Human pyocyanine increases expression EXP 6480464 Pyocyanine results in increased expression of GCLC mRNA CTD PMID:24015256 GCLC Human pyocyanine multiple interactions EXP 6480464 [Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of GCLC mRNA and trigonelline inhibits the reaction [Pyocyanine results in increased expression of GCLC mRNA] CTD PMID:24015256 GCLC Human pyrazines increases expression EXP 6480464 Pyrazines analog results in increased expression of GCLC mRNA CTD PMID:25056784 GCLC Human pyrethrins decreases expression ISO Gclc (Rattus norvegicus) 6480464 Pyrethrins results in decreased expression of GCLC protein CTD PMID:34896426 GCLC Human Pyridostigmine bromide multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of GCLC mRNA CTD PMID:28659758 GCLC Human pyrroloquinoline quinone multiple interactions ISO Gclc (Rattus norvegicus) 6480464 PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of GCLC mRNA] CTD PMID:26276080 GCLC Human quercetin increases expression EXP 6480464 Quercetin results in increased expression of GCLC mRNA and Quercetin results in increased expression of GCLC protein CTD PMID:11864778 more ... GCLC Human quercetin multiple interactions ISO Gclc (Mus musculus) 6480464 NFE2L2 protein affects the reaction [Quercetin results in increased expression of GCLC protein] CTD PMID:36584933 GCLC Human quercetin increases expression ISO Gclc (Rattus norvegicus) 6480464 Quercetin results in increased expression of GCLC mRNA and Quercetin results in increased expression of GCLC protein CTD PMID:19798679 more ... GCLC Human quercetin multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC mRNA more ... CTD PMID:19798679 more ... GCLC Human quercetin multiple interactions EXP 6480464 [clivorine co-treated with Quercetin] results in increased expression of GCLC mRNA more ... CTD PMID:25881548 GCLC Human quercetin increases expression ISO Gclc (Mus musculus) 6480464 Quercetin results in increased expression of GCLC mRNA and Quercetin results in increased expression of GCLC protein CTD PMID:19183254 and PMID:36584933 GCLC Human quercetin affects expression ISO Gclc (Rattus norvegicus) 6480464 Quercetin affects the expression of GCLC mRNA CTD PMID:18178720 GCLC Human rac-lactic acid increases expression EXP 6480464 Lactic Acid results in increased expression of GCLC mRNA CTD PMID:20566472 GCLC Human reactive oxygen species decreases abundance EXP 6480464 GCLC gene SNP results in decreased abundance of Reactive Oxygen Species CTD PMID:32715377 GCLC Human reactive oxygen species affects abundance ISO Gclc (Mus musculus) 6480464 GCLC protein affects the abundance of Reactive Oxygen Species CTD PMID:35123994 GCLC Human reactive oxygen species affects expression EXP 6480464 Reactive Oxygen Species affects the expression of GCLC mRNA CTD PMID:25800948 GCLC Human reactive oxygen species multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]] CTD PMID:22864849 GCLC Human reactive oxygen species multiple interactions EXP 6480464 [[[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein] which results in increased abundance of Glutathione and [[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein CTD PMID:21728338 GCLC Human resorcinol increases expression EXP 6480464 resorcinol results in increased expression of GCLC mRNA CTD PMID:30806763 GCLC Human resveratrol increases expression EXP 6480464 resveratrol results in increased expression of GCLC mRNA CTD PMID:11909699 more ... GCLC Human resveratrol multiple interactions ISO Gclc (Mus musculus) 6480464 NFE2L2 protein affects the reaction [Resveratrol results in increased expression of GCLC protein] CTD PMID:36584933 GCLC Human resveratrol multiple interactions ISO Gclc (Rattus norvegicus) 6480464 resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC mRNA] and resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC protein] CTD PMID:21439372 GCLC Human resveratrol increases expression ISO Gclc (Rattus norvegicus) 6480464 resveratrol results in increased expression of GCLC mRNA CTD PMID:15882976 GCLC Human resveratrol increases expression ISO Gclc (Mus musculus) 6480464 Resveratrol results in increased expression of GCLC mRNA and Resveratrol results in increased expression of GCLC protein CTD PMID:21520053 and PMID:36584933 GCLC Human resveratrol multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased expression of GCLC mRNA] more ... CTD PMID:11909699 more ... GCLC Human rosuvastatin calcium multiple interactions EXP 6480464 [Tetradecanoylphorbol Acetate co-treated with Rosuvastatin Calcium] results in increased expression of GCLC mRNA CTD PMID:18154958 GCLC Human rosuvastatin calcium increases expression EXP 6480464 Rosuvastatin Calcium results in increased expression of GCLC mRNA CTD PMID:18154958 GCLC Human rotenone increases expression ISO Gclc (Mus musculus) 6480464 Rotenone results in increased expression of GCLC mRNA CTD PMID:17657281 GCLC Human rotenone increases expression EXP 6480464 Rotenone results in increased expression of GCLC mRNA CTD PMID:36586010 GCLC Human rotenone decreases expression ISO Gclc (Rattus norvegicus) 6480464 Rotenone results in decreased expression of GCLC mRNA CTD PMID:26276080 GCLC Human rotenone multiple interactions ISO Gclc (Rattus norvegicus) 6480464 PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of GCLC mRNA] CTD PMID:26276080 GCLC Human rottlerin multiple interactions EXP 6480464 rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein] and rottlerin inhibits the reaction [Plant Extracts results in increased expression of GCLC protein] CTD PMID:24211276 and PMID:30626086 GCLC Human rottlerin multiple interactions ISO Gclc (Mus musculus) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA]] more ... CTD PMID:25895139 more ... GCLC Human rottlerin multiple interactions ISO Gclc (Rattus norvegicus) 6480464 rottlerin inhibits the reaction [naringin results in increased expression of GCLC protein] CTD PMID:25773745 GCLC Human S-adenosyl-L-methioninate multiple interactions EXP 6480464 S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA] and S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]] CTD PMID:20146260 GCLC Human S-adenosyl-L-methionine multiple interactions EXP 6480464 S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA] and S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]] CTD PMID:20146260 GCLC Human S-butyl-DL-homocysteine (S,R)-sulfoximine decreases activity ISO Gclc (Mus musculus) 6480464 Buthionine Sulfoximine results in decreased activity of GCLC protein CTD PMID:15707499 and PMID:7955076 GCLC Human S-butyl-DL-homocysteine (S,R)-sulfoximine decreases expression EXP 6480464 Buthionine Sulfoximine results in decreased expression of GCLC protein CTD PMID:35298964 GCLC Human S-butyl-DL-homocysteine (S,R)-sulfoximine increases expression ISO Gclc (Rattus norvegicus) 6480464 Buthionine Sulfoximine results in increased expression of GCLC mRNA CTD PMID:10978506 and PMID:23585199 GCLC Human S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions EXP 6480464 Buthionine Sulfoximine inhibits the reaction [[Lithocholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione] more ... CTD PMID:17724089 more ... GCLC Human S-butyl-DL-homocysteine (S,R)-sulfoximine decreases activity ISO Gclc (Rattus norvegicus) 6480464 Buthionine Sulfoximine results in decreased activity of GCLC protein CTD PMID:12433058 GCLC Human S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [Buthionine Sulfoximine co-treated with Carmustine] results in decreased activity of GCLC protein more ... CTD PMID:12967637 more ... GCLC Human S-butyl-DL-homocysteine (S,R)-sulfoximine increases expression ISO Gclc (Mus musculus) 6480464 Buthionine Sulfoximine results in increased expression of GCLC mRNA CTD PMID:17980396 more ... GCLC Human S-butyl-DL-homocysteine (S,R)-sulfoximine increases activity ISO Gclc (Mus musculus) 6480464 Buthionine Sulfoximine results in increased activity of GCLC protein CTD PMID:10915739 GCLC Human S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions ISO Gclc (Mus musculus) 6480464 [Buthionine Sulfoximine results in decreased activity of GCLC protein] inhibits the reaction [indenoindole results in increased abundance of Glutathione] more ... CTD PMID:10900227 more ... GCLC Human SB 203580 multiple interactions EXP 6480464 SB 203580 inhibits the reaction [Plant Extracts results in increased expression of GCLC protein] and SB 203580 inhibits the reaction [sodium arsenite results in increased expression of GCLC protein] CTD PMID:25201354 and PMID:30626086 GCLC Human SB 203580 multiple interactions ISO Gclc (Mus musculus) 6480464 SB 203580 inhibits the reaction [2' more ... CTD PMID:31029725 GCLC Human SB 431542 multiple interactions EXP 6480464 [LDN 193189 co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 and PMID:34480604 GCLC Human selenium atom multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of GCLC mRNA CTD PMID:11444866 GCLC Human selenocystine multiple interactions EXP 6480464 NFE2L2 mutant form inhibits the reaction [selenocystine results in increased expression of GCLC mRNA] CTD PMID:22807314 GCLC Human selenocystine increases expression EXP 6480464 selenocystine results in increased expression of GCLC mRNA CTD PMID:22807314 GCLC Human selenomethionine increases expression EXP 6480464 Selenomethionine results in increased expression of GCLC mRNA CTD PMID:22807314 GCLC Human sevoflurane multiple interactions ISO Gclc (Mus musculus) 6480464 alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of GCLC protein] CTD PMID:35350913 GCLC Human sevoflurane decreases expression ISO Gclc (Mus musculus) 6480464 Sevoflurane results in decreased expression of GCLC protein CTD PMID:35350913 GCLC Human silicon atom decreases expression ISO Gclc (Mus musculus) 6480464 Silicon results in decreased expression of GCLC protein CTD PMID:34252510 GCLC Human silicon atom multiple interactions ISO Gclc (Mus musculus) 6480464 Thioctic Acid inhibits the reaction [Silicon results in decreased expression of GCLC protein] CTD PMID:34252510 GCLC Human silicon dioxide decreases expression EXP 6480464 Silicon Dioxide analog results in decreased expression of GCLC mRNA CTD PMID:25895662 GCLC Human silicon dioxide decreases expression ISO Gclc (Mus musculus) 6480464 Silicon Dioxide results in decreased expression of GCLC mRNA CTD PMID:23221170 GCLC Human silver atom multiple interactions EXP 6480464 NFE2L2 protein affects the reaction [Silver results in increased expression of GCLC mRNA] CTD PMID:22546375 GCLC Human silver atom increases expression ISO Gclc (Mus musculus) 6480464 Silver results in increased expression of GCLC mRNA CTD PMID:27131904 GCLC Human silver atom increases expression EXP 6480464 Silver results in increased expression of GCLC mRNA CTD PMID:22036727 more ... GCLC Human silver(0) multiple interactions EXP 6480464 NFE2L2 protein affects the reaction [Silver results in increased expression of GCLC mRNA] CTD PMID:22546375 GCLC Human silver(0) increases expression ISO Gclc (Mus musculus) 6480464 Silver results in increased expression of GCLC mRNA CTD PMID:27131904 GCLC Human silver(0) increases expression EXP 6480464 Silver results in increased expression of GCLC mRNA CTD PMID:22036727 more ... GCLC Human silver(1+) nitrate decreases expression EXP 6480464 Silver Nitrate results in decreased expression of GCLC mRNA CTD PMID:19733233 GCLC Human SL-327 multiple interactions ISO Gclc (Mus musculus) 6480464 SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]] CTD PMID:25550330 GCLC Human sodium arsenate increases expression EXP 6480464 sodium arsenate results in increased expression of GCLC mRNA CTD PMID:12727804 GCLC Human sodium arsenate multiple interactions EXP 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of GCLC mRNA and [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of GCLC protein CTD PMID:32525701 and PMID:33434570 GCLC Human sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of GCLC mRNA and sodium arsenite results in increased expression of GCLC protein CTD PMID:12441363 more ... GCLC Human sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of GCLC mRNA CTD PMID:34032870 more ... GCLC Human sodium arsenite affects methylation EXP 6480464 sodium arsenite affects the methylation of GCLC gene CTD PMID:28589171 GCLC Human sodium arsenite increases expression ISO Gclc (Rattus norvegicus) 6480464 sodium arsenite results in increased expression of GCLC mRNA and sodium arsenite results in increased expression of GCLC protein CTD PMID:12210719 and PMID:21465251 GCLC Human sodium arsenite affects expression ISO Gclc (Rattus norvegicus) 6480464 sodium arsenite affects the expression of GCLC mRNA CTD PMID:25625412 GCLC Human sodium arsenite increases expression ISO Gclc (Mus musculus) 6480464 sodium arsenite results in increased expression of GCLC mRNA and sodium arsenite results in increased expression of GCLC protein CTD PMID:16014739 more ... GCLC Human sodium arsenite multiple interactions ISO Gclc (Mus musculus) 6480464 [GCLM co-treated with GCLC] inhibits the reaction [sodium arsenite results in increased activity of and results in increased cleavage of CASP3 protein] more ... CTD PMID:20006689 more ... GCLC Human sodium arsenite increases activity EXP 6480464 sodium arsenite results in increased activity of GCLC protein CTD PMID:12441363 GCLC Human sodium arsenite multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased expression of GCLC protein] more ... CTD PMID:20805060 more ... GCLC Human sodium cholate multiple interactions ISO Gclc (Mus musculus) 6480464 [Cholesterol more ... CTD PMID:27394961 GCLC Human sodium dichromate increases expression ISO Gclc (Rattus norvegicus) 6480464 sodium bichromate results in increased expression of GCLC mRNA CTD PMID:22561333 GCLC Human sodium dichromate increases expression ISO Gclc (Mus musculus) 6480464 sodium bichromate results in increased expression of GCLC mRNA CTD PMID:22155349 GCLC Human sodium dichromate decreases expression ISO Gclc (Mus musculus) 6480464 sodium bichromate results in decreased expression of GCLC mRNA CTD PMID:22155349 GCLC Human sodium dodecyl sulfate increases expression EXP 6480464 Sodium Dodecyl Sulfate results in increased expression of GCLC mRNA CTD PMID:20566472 GCLC Human sodium fluoride decreases expression ISO Gclc (Mus musculus) 6480464 Sodium Fluoride results in decreased expression of GCLC mRNA CTD PMID:27862939 GCLC Human spironolactone multiple interactions ISO Gclc (Rattus norvegicus) 6480464 Spironolactone inhibits the reaction [Aldosterone results in increased expression of GCLC protein] CTD PMID:24512358 and PMID:25204689 GCLC Human staurosporine multiple interactions EXP 6480464 Staurosporine promotes the reaction [MYC protein binds to GCLC promoter] CTD PMID:17628013 GCLC Human stavudine increases expression ISO Gclc (Rattus norvegicus) 6480464 Stavudine results in increased expression of GCLC mRNA CTD PMID:18299183 GCLC Human streptozocin multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC mRNA more ... CTD PMID:21439372 and PMID:33639173 GCLC Human streptozocin multiple interactions ISO Gclc (Mus musculus) 6480464 [Dietary Fats co-treated with Streptozocin] results in decreased expression of GCLC mRNA and ginsenoside Rh4 inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of GCLC mRNA] CTD PMID:33359794 GCLC Human streptozocin decreases expression ISO Gclc (Rattus norvegicus) 6480464 Streptozocin results in decreased expression of GCLC mRNA and Streptozocin results in decreased expression of GCLC protein CTD PMID:33639173 GCLC Human styrene increases activity ISO Gclc (Mus musculus) 6480464 Styrene results in increased activity of GCLC protein CTD PMID:16971035 GCLC Human succimer multiple interactions EXP 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of GCLC mRNA CTD PMID:26378955 GCLC Human sulfadimethoxine increases expression ISO Gclc (Rattus norvegicus) 6480464 Sulfadimethoxine results in increased expression of GCLC mRNA CTD PMID:30047161 GCLC Human sulforaphane multiple interactions ISO Gclc (Mus musculus) 6480464 [sulforaphane co-treated with Acetaminophen] results in increased expression of GCLC mRNA more ... CTD PMID:17942926 more ... GCLC Human sulforaphane decreases expression EXP 6480464 sulforaphane results in decreased expression of GCLC mRNA CTD PMID:35724838 GCLC Human sulforaphane decreases methylation EXP 6480464 sulforaphane results in decreased methylation of GCLC gene CTD PMID:31838189 GCLC Human sulforaphane increases expression ISO Gclc (Mus musculus) 6480464 sulforaphane results in increased expression of GCLC mRNA and sulforaphane results in increased expression of GCLC protein CTD PMID:17942926 more ... GCLC Human sulforaphane increases expression EXP 6480464 sulforaphane results in increased expression of GCLC mRNA and sulforaphane results in increased expression of GCLC protein CTD PMID:20442190 more ... GCLC Human sulforaphane increases expression ISO Gclc (Rattus norvegicus) 6480464 sulforaphane results in increased expression of GCLC mRNA and sulforaphane results in increased expression of GCLC protein CTD PMID:21871945 and PMID:22558124 GCLC Human sulforaphane multiple interactions ISO Gclc (Rattus norvegicus) 6480464 N-Methyl-3 and 4-methylenedioxyamphetamine inhibits the reaction [sulforaphane results in increased expression of GCLC mRNA] CTD PMID:21871945 GCLC Human sulforaphane multiple interactions EXP 6480464 alpha-methylepinine promotes the reaction [sulforaphane results in increased expression of GCLC mRNA] more ... CTD PMID:21871945 more ... GCLC Human sulindac multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Sulindac results in increased expression of GCLC protein] CTD PMID:11820781 GCLC Human sulindac increases expression EXP 6480464 Sulindac results in increased expression of GCLC protein CTD PMID:11820781 GCLC Human sulindac affects expression EXP 6480464 Sulindac affects the expression of GCLC mRNA CTD PMID:15946948 GCLC Human sunitinib increases expression EXP 6480464 Sunitinib results in increased expression of GCLC mRNA CTD PMID:31533062 GCLC Human suprofen increases expression EXP 6480464 Suprofen results in increased expression of GCLC mRNA CTD PMID:11909699 GCLC Human T-2 toxin decreases expression ISO Gclc (Mus musculus) 6480464 T-2 Toxin results in decreased expression of GCLC mRNA CTD PMID:20854872 GCLC Human T-2 toxin increases expression ISO Gclc (Mus musculus) 6480464 T-2 Toxin results in increased expression of GCLC mRNA CTD PMID:33508416 GCLC Human tamoxifen affects expression ISO Gclc (Mus musculus) 6480464 Tamoxifen affects the expression of GCLC mRNA CTD PMID:20937368 GCLC Human tectorigenin multiple interactions ISO Gclc (Mus musculus) 6480464 [tectorigenin co-treated with 1-Naphthylisothiocyanate] results in increased expression of GCLC protein and tectorigenin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of GCLC mRNA] CTD PMID:37348807 GCLC Human tert-butyl hydroperoxide multiple interactions EXP 6480464 [Linoleic Acids and Conjugated results in increased activity of GCLC protein] which results in decreased susceptibility to tert-Butylhydroperoxide CTD PMID:17092368 GCLC Human tert-butyl hydroperoxide decreases expression ISO Gclc (Mus musculus) 6480464 tert-Butylhydroperoxide results in decreased expression of GCLC mRNA CTD PMID:30547568 GCLC Human tert-butyl hydroperoxide increases expression EXP 6480464 tert-Butylhydroperoxide results in increased expression of GCLC mRNA CTD PMID:23410634 and PMID:27509014 GCLC Human tert-butyl hydroperoxide multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [Apigenin results in increased expression of GCLC mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide more ... CTD PMID:22864849 GCLC Human tert-butyl hydroperoxide decreases response to substance ISO Gclc (Rattus norvegicus) 6480464 GCLC protein results in decreased susceptibility to tert-Butylhydroperoxide CTD PMID:12425961 GCLC Human tetrachloromethane affects expression ISO Gclc (Mus musculus) 6480464 Carbon Tetrachloride affects the expression of GCLC mRNA CTD PMID:17484886 GCLC Human tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of GCLC mRNA CTD PMID:32234387 GCLC Human tetrachloromethane increases expression ISO Gclc (Rattus norvegicus) 6480464 Carbon Tetrachloride results in increased expression of GCLC mRNA CTD PMID:31150632 GCLC Human tetrachloromethane multiple interactions ISO Gclc (Mus musculus) 6480464 AK-1 compound promotes the reaction [Carbon Tetrachloride results in increased expression of GCLC mRNA] more ... CTD PMID:21725986 more ... GCLC Human tetrachloromethane decreases expression ISO Gclc (Mus musculus) 6480464 Carbon Tetrachloride results in decreased expression of GCLC mRNA and Carbon Tetrachloride results in decreased expression of GCLC protein CTD PMID:27477297 more ... GCLC Human tetrachloromethane multiple interactions ISO Gclc (Rattus norvegicus) 6480464 diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA] and schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of GCLC mRNA] CTD PMID:24293383 and PMID:31150632 GCLC Human tetrachloromethane decreases expression ISO Gclc (Rattus norvegicus) 6480464 Carbon Tetrachloride results in decreased expression of GCLC mRNA CTD PMID:24293383 GCLC Human tetrachloromethane increases expression ISO Gclc (Mus musculus) 6480464 Carbon Tetrachloride results in increased expression of GCLC mRNA and Carbon Tetrachloride results in increased expression of GCLC protein CTD PMID:10915739 more ... GCLC Human tetrachloromethane decreases activity ISO Gclc (Mus musculus) 6480464 Carbon Tetrachloride results in decreased activity of GCLC protein CTD PMID:10915739 GCLC Human tetramethylpyrazine increases expression EXP 6480464 tetramethylpyrazine analog results in increased expression of GCLC mRNA and tetramethylpyrazine analog results in increased expression of GCLC protein CTD PMID:25056784 GCLC Human tetramethylpyrazine multiple interactions ISO Gclc (Mus musculus) 6480464 NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]] more ... CTD PMID:27477297 GCLC Human thapsigargin increases expression ISO Gclc (Rattus norvegicus) 6480464 Thapsigargin results in increased expression of GCLC protein CTD PMID:35544339 GCLC Human thiabendazole increases activity ISO Gclc (Mus musculus) 6480464 Thiabendazole results in increased activity of GCLC protein CTD PMID:11019651 GCLC Human thiabendazole multiple interactions ISO Gclc (Mus musculus) 6480464 [Thiabendazole co-treated with Buthionine Sulfoximine] results in increased activity of GCLC protein CTD PMID:11019651 GCLC Human thioacetamide increases expression ISO Gclc (Rattus norvegicus) 6480464 Thioacetamide results in increased expression of GCLC mRNA and Thioacetamide results in increased expression of GCLC protein CTD PMID:10486302 more ... GCLC Human thioacetamide multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of GCLC mRNA CTD PMID:28943392 GCLC Human thiram decreases expression EXP 6480464 Thiram results in decreased expression of GCLC mRNA CTD PMID:38568856 GCLC Human titanium dioxide increases expression ISO Gclc (Mus musculus) 6480464 titanium dioxide results in increased expression of GCLC mRNA CTD PMID:23557971 GCLC Human titanium dioxide increases methylation ISO Gclc (Mus musculus) 6480464 titanium dioxide results in increased methylation of GCLC gene CTD PMID:35295148 GCLC Human titanium dioxide decreases expression ISO Gclc (Mus musculus) 6480464 titanium dioxide results in decreased expression of GCLC protein CTD PMID:28780322 GCLC Human titanium dioxide multiple interactions ISO Gclc (Mus musculus) 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of GCLC mRNA and Grape Seed Proanthocyanidins inhibits the reaction [titanium dioxide results in decreased expression of GCLC protein] CTD PMID:28780322 and PMID:29950665 GCLC Human topotecan multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of GCLC mRNA and [Topotecan co-treated with oxaliplatin] results in decreased expression of GCLC mRNA CTD PMID:25729387 GCLC Human topotecan decreases expression ISO Gclc (Rattus norvegicus) 6480464 Topotecan results in decreased expression of GCLC mRNA CTD PMID:25729387 GCLC Human trans-isoeugenol increases expression EXP 6480464 isoeugenol results in increased expression of GCLC mRNA CTD PMID:20566472 GCLC Human triacsin C increases expression EXP 6480464 triacsin C results in increased expression of GCLC mRNA CTD PMID:16704987 GCLC Human tributylstannane multiple interactions ISO Gclc (Mus musculus) 6480464 PRKCD gene mutant form promotes the reaction [tributyltin results in increased expression of GCLC mRNA] CTD PMID:25895139 GCLC Human Trichloroacetonitrile increases expression EXP 6480464 trichloroacetonitrile results in increased expression of GCLC mRNA CTD PMID:35842135 GCLC Human trichostatin A increases expression EXP 6480464 trichostatin A results in increased expression of GCLC mRNA CTD PMID:21319187 GCLC Human trichostatin A multiple interactions EXP 6480464 [Fenretinide co-treated with trichostatin A] results in increased expression of GCLC mRNA CTD PMID:21319187 GCLC Human trimethyltin increases expression ISO Gclc (Mus musculus) 6480464 trimethyltin results in increased expression of GCLC mRNA CTD PMID:25895139 GCLC Human trimethyltin multiple interactions ISO Gclc (Mus musculus) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA]] and rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA] CTD PMID:25895139 GCLC Human triphenyl phosphate affects expression EXP 6480464 triphenyl phosphate affects the expression of GCLC mRNA CTD PMID:37042841 GCLC Human triphenyl phosphate affects expression ISO Gclc (Rattus norvegicus) 6480464 triphenyl phosphate affects the expression of GCLC mRNA CTD PMID:30589522 GCLC Human Triptolide multiple interactions ISO Gclc (Rattus norvegicus) 6480464 NFE2L2 protein inhibits the reaction [triptolide results in decreased expression of GCLC protein] CTD PMID:25169008 GCLC Human Triptolide decreases expression ISO Gclc (Mus musculus) 6480464 triptolide results in decreased expression of GCLC protein CTD PMID:25169008 GCLC Human Triptolide decreases expression ISO Gclc (Rattus norvegicus) 6480464 triptolide results in decreased expression of GCLC protein CTD PMID:25169008 GCLC Human troglitazone increases expression EXP 6480464 troglitazone results in increased expression of GCLC mRNA CTD PMID:19140230 GCLC Human trovafloxacin decreases expression ISO Gclc (Rattus norvegicus) 6480464 trovafloxacin results in decreased expression of GCLC mRNA CTD PMID:24136188 GCLC Human trovafloxacin multiple interactions ISO Gclc (Mus musculus) 6480464 [trovafloxacin co-treated with lipopolysaccharide and E coli O55-B5] results in decreased expression of GCLC mRNA CTD PMID:18930950 GCLC Human tunicamycin increases expression ISO Gclc (Mus musculus) 6480464 Tunicamycin results in increased expression of GCLC mRNA CTD PMID:22959925 GCLC Human tunicamycin increases expression EXP 6480464 Tunicamycin results in increased expression of GCLC mRNA CTD PMID:36586010 GCLC Human tunicamycin multiple interactions ISO Gclc (Mus musculus) 6480464 NFE2L2 mRNA affects the reaction [Tunicamycin results in increased expression of GCLC mRNA] CTD PMID:22959925 GCLC Human tyloxapol multiple interactions ISO Gclc (Mus musculus) 6480464 Escin inhibits the reaction [tyloxapol results in decreased expression of GCLC protein] and Fenofibrate inhibits the reaction [tyloxapol results in decreased expression of GCLC protein] CTD PMID:36905866 GCLC Human tyloxapol decreases expression ISO Gclc (Mus musculus) 6480464 tyloxapol results in decreased expression of GCLC protein CTD PMID:36905866 GCLC Human tyrphostin AG 1478 multiple interactions ISO Gclc (Rattus norvegicus) 6480464 Doxorubicin promotes the reaction [RTKI cpd results in decreased expression of GCLC protein] CTD PMID:18371937 GCLC Human tyrphostin AG 1478 decreases expression ISO Gclc (Rattus norvegicus) 6480464 RTKI cpd results in decreased expression of GCLC protein CTD PMID:18371937 GCLC Human urethane increases expression EXP 6480464 Urethane results in increased expression of GCLC mRNA CTD PMID:28818685 GCLC Human ursodeoxycholic acid multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased expression of GCLC mRNA] more ... CTD PMID:19073151 and PMID:20146260 GCLC Human ursodeoxycholic acid increases expression ISO Gclc (Mus musculus) 6480464 Ursodeoxycholic Acid results in increased expression of GCLC mRNA and Ursodeoxycholic Acid results in increased expression of GCLC protein CTD PMID:18687751 GCLC Human ursodeoxycholic acid increases expression EXP 6480464 Ursodeoxycholic Acid results in increased expression of GCLC mRNA CTD PMID:19073151 GCLC Human ursodeoxycholic acid multiple interactions ISO Gclc (Mus musculus) 6480464 NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of GCLC mRNA] CTD PMID:18687751 GCLC Human usnic acid multiple interactions EXP 6480464 NFE2L2 protein promotes the reaction [usnic acid results in increased expression of GCLC protein] CTD PMID:27369375 GCLC Human usnic acid increases expression EXP 6480464 usnic acid results in increased expression of GCLC mRNA and usnic acid results in increased expression of GCLC protein CTD PMID:27369375 GCLC Human valdecoxib increases expression ISO Gclc (Rattus norvegicus) 6480464 valdecoxib results in increased expression of GCLC mRNA CTD PMID:24136188 GCLC Human valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of GCLC mRNA CTD PMID:25716160 GCLC Human vanillin increases expression EXP 6480464 vanillin results in increased expression of GCLC mRNA CTD PMID:17178418 GCLC Human vincristine multiple interactions EXP 6480464 [GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Vincristine CTD PMID:10900222 GCLC Human vitamin E multiple interactions ISO Gclc (Mus musculus) 6480464 Vitamin E inhibits the reaction [Alcohols results in increased expression of GCLC mRNA] CTD PMID:18814483 GCLC Human vitamin E multiple interactions ISO Gclc (Rattus norvegicus) 6480464 [Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of GCLC mRNA and Vitamin E affects the reaction [[REL binds to GCLC promoter] which affects the expression of GCLC mRNA] CTD PMID:11444866 and PMID:16298738 GCLC Human vitamin E affects expression ISO Gclc (Rattus norvegicus) 6480464 Vitamin E affects the expression of GCLC mRNA and Vitamin E affects the expression of GCLC protein CTD PMID:16298738 GCLC Human water multiple interactions ISO Gclc (Mus musculus) 6480464 [[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in increased expression of GCLC mRNA CTD PMID:29335169 GCLC Human withaferin A multiple interactions ISO Gclc (Mus musculus) 6480464 withaferin A inhibits the reaction [Ethanol results in increased expression of GCLC mRNA] CTD PMID:34995708 GCLC Human XAV939 multiple interactions EXP 6480464 [[ascorbate-2-phosphate co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein] co-treated with [INHBA protein binds to INHBA protein]] results in increased expression of GCLC mRNA CTD PMID:34480604 GCLC Human yohimbine multiple interactions ISO Gclc (Mus musculus) 6480464 [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GCLC mRNA CTD PMID:28843594 GCLC Human zinc atom multiple interactions EXP 6480464 acetyl-valyl-isoleucyl-aspartyl-aldehyde inhibits the reaction [Zinc deficiency results in increased cleavage of GCLC protein] more ... CTD PMID:23377617 GCLC Human zinc atom decreases expression EXP 6480464 Zinc deficiency results in decreased expression of GCLC mRNA CTD PMID:23377617 GCLC Human zinc atom decreases expression ISO Gclc (Rattus norvegicus) 6480464 Zinc deficiency results in decreased expression of GCLC mRNA and Zinc deficiency results in decreased expression of GCLC protein CTD PMID:23377617 GCLC Human zinc dichloride multiple interactions EXP 6480464 zinc chloride promotes the reaction [SLC39A2 protein results in increased expression of GCLC mRNA] CTD PMID:18385089 GCLC Human zinc dichloride increases expression EXP 6480464 zinc chloride results in increased expression of GCLC mRNA CTD PMID:33645215 GCLC Human zinc oxide multiple interactions ISO Gclc (Mus musculus) 6480464 1-(2-cyano-3 more ... CTD PMID:30500950 more ... GCLC Human zinc oxide increases expression ISO Gclc (Mus musculus) 6480464 Zinc Oxide analog results in increased expression of GCLC protein CTD PMID:35247504 GCLC Human zinc oxide decreases expression ISO Gclc (Mus musculus) 6480464 Zinc Oxide analog results in decreased expression of GCLC mRNA CTD PMID:36100149 GCLC Human zinc(0) multiple interactions EXP 6480464 acetyl-valyl-isoleucyl-aspartyl-aldehyde inhibits the reaction [Zinc deficiency results in increased cleavage of GCLC protein] more ... CTD PMID:23377617 GCLC Human zinc(0) decreases expression ISO Gclc (Rattus norvegicus) 6480464 Zinc deficiency results in decreased expression of GCLC mRNA and Zinc deficiency results in decreased expression of GCLC protein CTD PMID:23377617 GCLC Human zinc(0) decreases expression EXP 6480464 Zinc deficiency results in decreased expression of GCLC mRNA CTD PMID:23377617
