Ireb2 (iron responsive element binding protein 2) - Rat Genome Database

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Gene: Ireb2 (iron responsive element binding protein 2) Mus musculus
Analyze
Symbol: Ireb2
Name: iron responsive element binding protein 2
RGD ID: 736754
MGI Page MGI
Description: Enables iron-responsive element binding activity. Involved in osteoclast differentiation. Acts upstream of or within several processes, including intestinal absorption; iron ion homeostasis; and protoporphyrinogen IX biosynthetic process. Located in cytosol. Is expressed in several structures, including nervous system and yolk sac. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human IREB2 (iron responsive element binding protein 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: D9Ertd85; D9Ertd85e; DKFZp564D1164; I; IRE-BP 2; iron regulatory protein 2; iron-responsive element-binding protein 2; Irp2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39954,769,942 - 54,819,818 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl954,771,073 - 54,819,814 (+)EnsemblGRCm39 Ensembl
GRCm38954,862,658 - 54,912,534 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl954,863,789 - 54,912,530 (+)EnsemblGRCm38mm10GRCm38
MGSCv37954,711,562 - 54,760,341 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36954,661,926 - 54,708,169 (+)NCBIMGSCv36mm8
Celera952,108,353 - 52,158,699 (+)NCBICelera
Cytogenetic Map9BNCBI
cM Map929.81NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
4-hydroxy-TEMPO  (EXP)
5-fluorouracil  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
desferrioxamine B  (EXP,ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
etoposide  (ISO)
ferric ammonium citrate  (EXP,ISO)
finasteride  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
formaldehyde  (ISO)
furan  (ISO)
gentamycin  (ISO)
glucose  (ISO)
hemin  (ISO)
iron atom  (EXP,ISO)
iron(0)  (EXP,ISO)
L-ascorbic acid  (EXP)
lipopolysaccharide  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
Methylazoxymethanol acetate  (ISO)
methylmercury chloride  (ISO)
miconazole  (EXP)
monosodium L-glutamate  (ISO)
N-acetyl-L-cysteine  (EXP)
nefazodone  (ISO)
okadaic acid  (ISO)
oxidopamine  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phorone  (ISO)
phosphane  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
protein kinase inhibitor  (EXP)
rac-lactic acid  (ISO)
resveratrol  (ISO)
Ro 41-5253  (ISO)
SB 431542  (ISO)
sunitinib  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
trichloroethene  (EXP,ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (ISO)
cytoplasm  (IDA)
cytosol  (IBA,IDA,ISO)
cytosol  (ISO)
endoplasmic reticulum  (ISO)
Golgi apparatus  (ISO)
mitochondrion  (HDA,IBA)
neuronal cell body  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal axon morphology  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal cerebellum white matter morphology  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal corpora quadrigemina morphology  (IAGP)
abnormal corpus callosum morphology  (IAGP)
abnormal dorsal striatum morphology  (IAGP)
abnormal duodenum morphology  (IAGP)
abnormal erythrocyte morphology  (IAGP)
abnormal gait  (IAGP)
abnormal hippocampal pyramidal neuron dendrite morphology  (IAGP)
abnormal hippocampus pyramidal cell morphology  (IAGP)
abnormal iron homeostasis  (IAGP)
abnormal iron level  (IAGP)
abnormal locomotor behavior  (IAGP)
abnormal oligodendrocyte morphology  (IAGP)
abnormal posture  (IAGP)
abnormal Purkinje cell morphology  (IAGP)
abnormal superior colliculus morphology  (IAGP)
abnormal thalamus morphology  (IAGP)
abnormal vestibular system physiology  (IAGP)
anemia  (IAGP)
ataxia  (IAGP)
bradykinesia  (IAGP)
decreased brain iron level  (IAGP)
decreased circulating unsaturated transferrin level  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased grip strength  (IAGP)
decreased heart iron level  (IAGP)
decreased hematocrit  (IAGP)
decreased hemoglobin content  (IAGP)
decreased liver iron level  (IAGP)
decreased locomotor activity  (IAGP)
decreased mean corpuscular hemoglobin  (IAGP)
decreased mean corpuscular hemoglobin concentration  (IAGP)
decreased mean corpuscular volume  (IAGP)
decreased mean platelet volume  (IAGP)
decreased Purkinje cell number  (IAGP)
decreased spleen iron level  (IAGP)
decreased vertical activity  (IAGP)
impaired balance  (IAGP)
impaired coordination  (IAGP)
increased brain iron level  (IAGP)
increased circulating ferritin level  (IAGP)
increased circulating iron level  (IAGP)
increased intestinal iron level  (IAGP)
increased kidney iron level  (IAGP)
increased liver iron level  (IAGP)
increased porphyrin level  (IAGP)
increased red blood cell distribution width  (IAGP)
increased thermal nociceptive threshold  (IAGP)
kyphosis  (IAGP)
microcytic anemia  (IAGP)
microcytosis  (IAGP)
no abnormal phenotype detected  (IAGP)
porphyria  (IAGP)
Purkinje cell degeneration  (IAGP)
thrombocytopenia  (IAGP)
tremors  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Surgical trauma induces iron accumulation and oxidative stress in a rodent model of postoperative cognitive dysfunction. An LN, etal., Biol Trace Elem Res. 2013 Feb;151(2):277-83. doi: 10.1007/s12011-012-9564-9. Epub 2012 Dec 11.
2. Deficiency of Calcium-Independent Phospholipase A2 Beta Induces Brain Iron Accumulation through Upregulation of Divalent Metal Transporter 1. Beck G, etal., PLoS One. 2015 Oct 27;10(10):e0141629. doi: 10.1371/journal.pone.0141629. eCollection 2015.
3. Preliminary demonstration of an allelic association of the IREB2 gene with Alzheimer's disease. Coon KD, etal., J Alzheimers Dis. 2006 Aug;9(3):225-33.
4. mRNA expression of proteins involved in iron homeostasis in brain regions is altered by age and by iron overloading in the neonatal period. Dornelles AS, etal., Neurochem Res. 2010 Apr;35(4):564-71. Epub 2009 Nov 27.
5. The role of iron in anthracycline cardiotoxicity. Gammella E, etal., Front Pharmacol. 2014 Feb 26;5:25. doi: 10.3389/fphar.2014.00025. eCollection 2014.
6. Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice. Ghosh MC, etal., Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):12028-33. Epub 2008 Aug 6.
7. Vitamin A deficiency aggravates iron deficiency by upregulating the expression of iron regulatory protein-2. Jiang S, etal., Nutrition. 2012 Mar;28(3):281-7. doi: 10.1016/j.nut.2011.08.015. Epub 2011 Dec 9.
8. Hyperinsulinemia induces hepatic iron overload by increasing liver TFR1 via the PI3K/IRP2 pathway. Jiang X, etal., J Mol Endocrinol. 2014 Dec;53(3):381-92. doi: 10.1530/JME-14-0122.
9. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
10. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Lane DJ, etal., Biochim Biophys Acta. 2015 May;1853(5):1130-44. doi: 10.1016/j.bbamcr.2015.01.021. Epub 2015 Feb 4.
11. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
12. MGDs mouse GO annotations MGD data from the GO Consortium
13. MGD IEA MGD IEA
14. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
15. Iron and iron regulatory proteins in amoeboid microglial cells are linked to oligodendrocyte death in hypoxic neonatal rat periventricular white matter through production of proinflammatory cytokines and reactive oxygen/nitrogen species. Rathnasamy G, etal., J Neurosci. 2011 Dec 7;31(49):17982-95.
16. Mouse MP Annotation Import Pipeline RGD automated import pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Iron regulatory protein 1 is not required for the modulation of ferritin and transferrin receptor expression by iron in a murine pro-B lymphocyte cell line. Schalinske KL, etal., Proc Natl Acad Sci U S A 1997 Sep 30;94(20):10681-6.
20. Iron regulatory protein as an endogenous sensor of iron in rat intestinal mucosa. Possible implications for the regulation of iron absorption. Schümann K, etal., Eur J Biochem. 1999 Mar;260(2):362-72.
21. Insights into the role of iron in immature rat model of hypoxic-ischemic brain injury. Wang ZW, etal., Exp Ther Med. 2016 Sep;12(3):1723-1731. Epub 2016 Jul 26.
22. Molecular pharmacology of the interaction of anthracyclines with iron. Xu X, etal., Mol Pharmacol. 2005 Aug;68(2):261-71. Epub 2005 May 9.
23. Effects of ferrous carbamoyl glycine on iron state and absorption in an iron-deficient rat model. Zhang Y, etal., Genes Nutr. 2015 Nov;10(6):54. doi: 10.1007/s12263-015-0504-0. Epub 2015 Nov 19.
24. [Expression of iron regulatory protein-2 and ferritins in intestinal mucosa of rats with iron deficiency]. Zuo WL, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Jun;16(3):565-8.
Additional References at PubMed
PMID:8262972   PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11175792   PMID:11217851   PMID:12477932   PMID:12520002   PMID:12691842   PMID:14610273  
PMID:14681479   PMID:14691545   PMID:14726953   PMID:15105256   PMID:15208438   PMID:15354085   PMID:15489334   PMID:15604406   PMID:15831703   PMID:15866737   PMID:15956281   PMID:16051392  
PMID:16107646   PMID:16141072   PMID:16141073   PMID:16144863   PMID:16283625   PMID:16787915   PMID:16940998   PMID:17560557   PMID:17614197   PMID:18177727   PMID:18571425   PMID:18614015  
PMID:18655771   PMID:18694996   PMID:18799693   PMID:19252502   PMID:19533074   PMID:19584448   PMID:19723774   PMID:19965627   PMID:20399759   PMID:20674864   PMID:21267068   PMID:21281640  
PMID:21566147   PMID:21677750   PMID:21873635   PMID:21907140   PMID:21940823   PMID:22003390   PMID:22496346   PMID:23135277   PMID:23395174   PMID:23777768   PMID:24896637   PMID:25636453  
PMID:25651183   PMID:25771171   PMID:26160903   PMID:26190773   PMID:26752519   PMID:26797126   PMID:28069738   PMID:28714470   PMID:29470856   PMID:30685084   PMID:30877170   PMID:31040213  
PMID:31907996   PMID:31941883   PMID:32276991   PMID:32325033   PMID:32554809   PMID:32947011   PMID:34593646   PMID:34675764   PMID:35490179  


Genomics

Comparative Map Data
Ireb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39954,769,942 - 54,819,818 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl954,771,073 - 54,819,814 (+)EnsemblGRCm39 Ensembl
GRCm38954,862,658 - 54,912,534 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl954,863,789 - 54,912,530 (+)EnsemblGRCm38mm10GRCm38
MGSCv37954,711,562 - 54,760,341 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36954,661,926 - 54,708,169 (+)NCBIMGSCv36mm8
Celera952,108,353 - 52,158,699 (+)NCBICelera
Cytogenetic Map9BNCBI
cM Map929.81NCBI
IREB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381578,437,431 - 78,501,453 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1578,437,431 - 78,501,453 (+)EnsemblGRCh38hg38GRCh38
GRCh371578,729,773 - 78,793,795 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361576,517,573 - 76,580,853 (+)NCBINCBI36Build 36hg18NCBI36
Build 341576,517,680 - 76,578,522NCBI
Celera1555,667,049 - 55,730,320 (+)NCBICelera
Cytogenetic Map15q25.1NCBI
HuRef1555,487,914 - 55,551,183 (+)NCBIHuRef
CHM1_11578,849,070 - 78,912,332 (+)NCBICHM1_1
T2T-CHM13v2.01576,300,098 - 76,364,103 (+)NCBIT2T-CHM13v2.0
Ireb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2855,228,080 - 55,311,613 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl855,228,085 - 55,311,611 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx860,806,571 - 60,850,679 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0859,085,567 - 59,129,675 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0856,949,805 - 56,993,913 (+)NCBIRnor_WKY
Rnor_6.0859,450,974 - 59,503,634 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl859,420,123 - 59,501,118 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0858,002,720 - 58,085,793 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4858,433,218 - 58,477,305 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1858,452,371 - 58,496,928 (+)NCBI
Celera854,752,036 - 54,796,112 (+)NCBICelera
Cytogenetic Map8q24NCBI
Ireb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955450852,554 - 900,011 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955450852,554 - 898,908 (+)NCBIChiLan1.0ChiLan1.0
IREB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11576,331,610 - 76,394,476 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1576,331,610 - 76,394,476 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01557,367,314 - 57,430,322 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
IREB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11338,398,445 - 38,441,128 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1338,400,591 - 38,441,015 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1338,376,325 - 38,418,383 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01338,889,612 - 38,931,847 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1338,889,614 - 38,931,872 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11338,580,619 - 38,622,667 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01338,690,365 - 38,732,612 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01339,165,328 - 39,207,352 (-)NCBIUU_Cfam_GSD_1.0
Ireb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640118,699,487 - 118,752,521 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647136,547,500 - 36,600,636 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493647136,547,552 - 36,601,327 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IREB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl747,478,706 - 47,529,242 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1747,481,539 - 47,529,199 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2752,974,224 - 53,021,936 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IREB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1264,842,328 - 4,905,941 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl264,842,122 - 4,905,964 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048136,891,175 - 136,954,571 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ireb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248942,445,704 - 2,499,009 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248942,446,014 - 2,498,650 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:801
Count of miRNA genes:458
Interacting mature miRNAs:557
Transcripts:ENSMUST00000034843
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92085274054852740Mouse
13208563Bmiq8_mbody mass index QTL 8 (mouse)92491129668907282Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92558748559587581Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92558748559587581Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92558748559587581Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92558748559587581Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92679642160796552Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92679642160796552Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92679642160796552Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92725119461251323Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92929292963293072Mouse
1301782Chol11_mcholesterol 11 (mouse)Not determined92929292963293072Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93005316464053277Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93073991564740021Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93243456366434857Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93245242166452546Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93251117266511421Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93288970266889836Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93311102567111140Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93397884073439255Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93503447869034599Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93503447869034599Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93503447869034599Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93730619798701707Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93781952871819528Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93809957572099575Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93809957572099575Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93809957572099575Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93939988573399885Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94041959474607925Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94080504774805204Mouse
1301558Stheal8_msoft tissue heal 8 (mouse)Not determined94348071477480860Mouse
10045639Heal28_mwound healing/regeneration 28 (mouse)Not determined94348071477480860Mouse
1301435Trigq1_mtriglyceride QTL 1 (mouse)Not determined94442817478428262Mouse
4141572Ntta3_mneurotensin transcript abundance 3 (mouse)Not determined4659767165831177Mouse
4141754Fecq4_mfecundity QTL 4 (mouse)Not determined94754302457805204Mouse
1300563Pgia5_mproteoglycan induced arthritis 5 (mouse)Not determined94883105682831177Mouse
1300716Cd4ts4_mCD4 T cell subset 4 (mouse)Not determined94883105682831177Mouse
1301051Eae9_msusceptibility to experimental allergic encephalomyelitis 9 (mouse)Not determined94942029863239852Mouse
1301049El4_mepilepsy 4 (mouse)Not determined94942029867151448Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49452421101406120Mouse
14746993Manh66_mmandible shape 66 (mouse)94981404883814048Mouse
1301184Bdln4_mbody length 4 (mouse)Not determined95015132084151448Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95203447899792481Mouse
13525008Hrtiq1_mheart rate time index, QTL 1 (mouse)95242609868556008Mouse
12790990Tgl7_mtriglyceride 7 (mouse)95455996088559960Mouse

Markers in Region
C77958  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38954,911,981 - 54,912,279UniSTSGRCm38
MGSCv37954,759,788 - 54,760,086UniSTSGRCm37
Celera952,158,146 - 52,158,444UniSTS
Cytogenetic Map9BUniSTS
cM Map929.0UniSTS
Whitehead/MRC_RH9541.04UniSTS
RH126278  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38954,912,178 - 54,912,384UniSTSGRCm38
MGSCv37954,759,985 - 54,760,191UniSTSGRCm37
Celera952,158,343 - 52,158,549UniSTS
Cytogenetic Map9BUniSTS
cM Map929.0UniSTS
Whitehead/MRC_RH9539.12UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006511335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017313500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC159892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC161264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF016402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK034218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK038058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK049315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC044665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ093933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK636500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN534597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN664620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO431396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV558274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF437328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000034843   ⟹   ENSMUSP00000034843
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl954,771,073 - 54,819,814 (+)Ensembl
GRCm38.p6 Ensembl954,863,789 - 54,912,530 (+)Ensembl
RefSeq Acc Id: ENSMUST00000213482
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl954,809,489 - 54,813,431 (+)Ensembl
GRCm38.p6 Ensembl954,902,205 - 54,906,147 (+)Ensembl
RefSeq Acc Id: ENSMUST00000214023   ⟹   ENSMUSP00000149766
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl954,804,757 - 54,811,271 (+)Ensembl
GRCm38.p6 Ensembl954,897,473 - 54,903,987 (+)Ensembl
RefSeq Acc Id: NM_022655   ⟹   NP_073146
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39954,771,039 - 54,819,818 (+)NCBI
GRCm38954,863,755 - 54,912,534 (+)NCBI
MGSCv37954,711,562 - 54,760,341 (+)RGD
Celera952,108,353 - 52,158,699 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006511335   ⟹   XP_006511398
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39954,769,942 - 54,810,784 (+)NCBI
GRCm38954,862,658 - 54,903,500 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017313500   ⟹   XP_017168989
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39954,770,983 - 54,811,511 (+)NCBI
GRCm38954,863,701 - 54,904,227 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036155171   ⟹   XP_036011064
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39954,769,942 - 54,819,814 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_073146   ⟸   NM_022655
- UniProtKB: O70235 (UniProtKB/Swiss-Prot),   Q811J3 (UniProtKB/Swiss-Prot),   A0A8C6GDN7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006511398   ⟸   XM_006511335
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017168989   ⟸   XM_017313500
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSMUSP00000034843   ⟸   ENSMUST00000034843
RefSeq Acc Id: ENSMUSP00000149766   ⟸   ENSMUST00000214023
RefSeq Acc Id: XP_036011064   ⟸   XM_036155171
- Peptide Label: isoform X2
Protein Domains
Aconitase A/isopropylmalate dehydratase small   Aconitase/3-isopropylmalate dehydratase large

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q811J3-F1-model_v2 AlphaFold Q811J3 1-963 view protein structure

Promoters
RGD ID:6844698
Promoter ID:MM_KWN:57450
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_022655
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36954,711,221 - 54,711,721 (+)MPROMDB
RGD ID:8669650
Promoter ID:EPDNEW_M12856
Type:initiation region
Name:Ireb2_1
Description:Mus musculus iron responsive element binding protein 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38954,863,766 - 54,863,826EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1928268 AgrOrtholog
Ensembl Genes ENSMUSG00000032293 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000034843 ENTREZGENE
  ENSMUSP00000034843.8 UniProtKB/Swiss-Prot
  ENSMUSP00000149766.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034843 ENTREZGENE
  ENSMUST00000034843.9 UniProtKB/Swiss-Prot
  ENSMUST00000214023.2 UniProtKB/TrEMBL
Gene3D-CATH 3.20.19.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.499.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AcnA_IRP_Swivel UniProtKB/Swiss-Prot
  Acnase/IPM_dHydase_lsu_aba_1/3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acoase/IPM_deHydtase_lsu_aba UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aconitase/3IPM_dehydase_swvl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aconitase/IRP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aconitase_4Fe-4S_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aconitase_4Fe-4S_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AconitaseA/IPMdHydase_ssu_swvl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:64602 UniProtKB/Swiss-Prot
MGD MGI:1928268 ENTREZGENE
NCBI Gene 64602 ENTREZGENE
PANTHER PTHR11670 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11670:SF31 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aconitase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aconitase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ireb2 PhenoGen
PRINTS ACONITASE UniProtKB/Swiss-Prot
PROSITE ACONITASE_1 UniProtKB/Swiss-Prot
  ACONITASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP LeuD/IlvD-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53732 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs aconitase_1 UniProtKB/Swiss-Prot
UniProt A0A1L1SS62_MOUSE UniProtKB/TrEMBL
  A0A8C6GDN7 ENTREZGENE
  IREB2_MOUSE UniProtKB/Swiss-Prot
  O70235 ENTREZGENE
  Q811J3 ENTREZGENE
  Q8BWZ6_MOUSE UniProtKB/TrEMBL
  Q8BZL2_MOUSE UniProtKB/TrEMBL
UniProt Secondary E9QPM2 UniProtKB/Swiss-Prot
  O70235 UniProtKB/Swiss-Prot