Pitx1 (paired-like homeodomain transcription factor 1) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Pitx1 (paired-like homeodomain transcription factor 1) Mus musculus
Analyze
Symbol: Pitx1
Name: paired-like homeodomain transcription factor 1
RGD ID: 736734
MGI Page MGI
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in embryonic hindlimb morphogenesis; negative regulation of DNA-templated transcription; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including branchiomeric skeletal muscle development; hindlimb morphogenesis; and myoblast fate commitment. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; brain; branchial arch; limb; and sensory organ. Used to study clubfoot. Human ortholog(s) of this gene implicated in clubfoot. Orthologous to human PITX1 (paired like homeodomain 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Bft; hindlimb-expressed homeobox protein backfoot; homeobox protein P-OTX; homeobox protein PITX1; P-O; P-OTX; pituitary homeobox 1; pituitary OTX-related factor; Po; Potx; Ptx; Ptx1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391355,972,857 - 55,984,002 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1355,972,864 - 55,984,005 (-)EnsemblGRCm39 Ensembl
GRCm381355,825,044 - 55,836,190 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1355,825,051 - 55,836,192 (-)EnsemblGRCm38mm10GRCm38
MGSCv371355,926,415 - 55,932,786 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361355,834,676 - 55,841,047 (-)NCBIMGSCv36mm8
Celera1356,876,993 - 56,883,263 (-)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1330.06NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adipose tissue amount  (IAGP)
abnormal artery morphology  (IAGP)
abnormal autopod morphology  (IEA)
abnormal cartilage morphology  (IAGP)
abnormal cornea morphology  (IEA)
abnormal digit morphology  (IEA)
abnormal femur morphology  (IAGP)
abnormal fibula morphology  (IAGP)
abnormal hindlimb morphology  (IAGP)
abnormal joint morphology  (IEA)
abnormal long bone epiphyseal plate morphology  (IAGP)
abnormal Meckel's cartilage morphology  (IAGP)
abnormal middle ear ossicle morphology  (IAGP)
abnormal nail morphology  (IEA)
abnormal pelvic girdle bone morphology  (IAGP)
abnormal pituitary gland morphology  (IAGP)
abnormal postnatal growth  (IAGP)
abnormal Rathke's pouch development  (IAGP)
abnormal tarsal bone morphology  (IAGP)
abnormal tibia morphology  (IAGP)
absent femur  (IAGP)
absent gonial bone  (IAGP)
absent ilium  (IAGP)
absent patella  (IAGP)
absent sesamoid bone of gastrocnemius  (IAGP)
absent submandibular gland  (IAGP)
absent tibia  (IAGP)
bifurcated tongue  (IAGP)
brachydactyly  (IAGP)
cleft palate  (IAGP)
cleft secondary palate  (IAGP)
clubfoot  (IAGP)
decreased bone volume  (IAGP)
decreased gonadotroph cell number  (IAGP)
decreased thyrotroph cell number  (IAGP)
decreased tympanic ring size  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
failure of palatal shelf elevation  (IAGP)
fused phalanges  (IEA)
hindlimb oligodactyly  (IAGP)
increased width of hypertrophic chondrocyte zone  (IAGP)
micrognathia  (IAGP)
muscle hypoplasia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
oligodactyly  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
polysyndactyly  (IEA)
preweaning lethality, complete penetrance  (IEA)
short femur  (IAGP)
short hindlimb  (IAGP)
short mandible  (IAGP)
short tibia  (IAGP)
short tongue  (IAGP)
small hindlimb buds  (IAGP)
small ischium  (IAGP)
small limb buds  (IAGP)
small mandible  (IAGP)
small pubis  (IAGP)
small Rathke's pouch  (IAGP)
vertebral transformation  (IEA)
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8675014   PMID:8755540   PMID:8934515   PMID:9026314   PMID:9070926   PMID:9186059   PMID:9192866   PMID:9207461   PMID:9226452   PMID:9337397   PMID:9347917   PMID:9514159  
PMID:9620855   PMID:9736723   PMID:9806931   PMID:9922405   PMID:10049363   PMID:10067870   PMID:10101115   PMID:10349636   PMID:10431247   PMID:10588713   PMID:10601039   PMID:10603081  
PMID:10625557   PMID:10861284   PMID:11042159   PMID:11044393   PMID:11076861   PMID:11217851   PMID:11353389   PMID:11420609   PMID:11447259   PMID:11474193   PMID:11598925   PMID:11807026  
PMID:11829488   PMID:11991718   PMID:12086465   PMID:12142027   PMID:12183375   PMID:12193642   PMID:12434331   PMID:12441290   PMID:12466851   PMID:12477932   PMID:12490567   PMID:12730328  
PMID:12736212   PMID:12736217   PMID:12810588   PMID:12858527   PMID:14512705   PMID:14623826   PMID:14681479   PMID:14726486   PMID:15107405   PMID:15110048   PMID:15226417   PMID:15385555  
PMID:15489334   PMID:15618518   PMID:15621531   PMID:15703188   PMID:15716346   PMID:15753378   PMID:15761027   PMID:15809042   PMID:15936012   PMID:16141072   PMID:16141073   PMID:16203745  
PMID:16289463   PMID:16380715   PMID:16602821   PMID:16751105   PMID:16859901   PMID:16960803   PMID:16989801   PMID:17359964   PMID:17384148   PMID:17904116   PMID:17919533   PMID:17942481  
PMID:18037398   PMID:18077221   PMID:18082678   PMID:18231602   PMID:18287559   PMID:18327786   PMID:18339718   PMID:18498097   PMID:18697905   PMID:19017795   PMID:19168678   PMID:19300477  
PMID:19464179   PMID:19531352   PMID:19653318   PMID:19777594   PMID:19900438   PMID:19995909   PMID:20059953   PMID:20333701   PMID:20501333   PMID:20563669   PMID:20685737   PMID:20816801  
PMID:20975709   PMID:21035439   PMID:21098569   PMID:21122108   PMID:21267068   PMID:21300782   PMID:21455939   PMID:21531785   PMID:21558373   PMID:21775501   PMID:21873635   PMID:21896782  
PMID:21937598   PMID:21964592   PMID:22071103   PMID:22174793   PMID:22421546   PMID:22438573   PMID:22844247   PMID:22945632   PMID:22972626   PMID:23028704   PMID:23201014   PMID:23201021  
PMID:23754280   PMID:23942202   PMID:24146773   PMID:24227653   PMID:24316575   PMID:24424161   PMID:24650709   PMID:24780627   PMID:24785830   PMID:24952961   PMID:25315894   PMID:25889273  
PMID:27120339   PMID:27329940   PMID:27453501   PMID:27654891   PMID:27736991   PMID:28052057   PMID:28069742   PMID:28511701   PMID:28746404   PMID:28807898   PMID:28807899   PMID:29273440  
PMID:29463648   PMID:29549111   PMID:29705333   PMID:30262816   PMID:30499775   PMID:30713093   PMID:30837642   PMID:30916783   PMID:30973865   PMID:31813798   PMID:32017444   PMID:32268095  
PMID:32515350   PMID:32597756   PMID:33328221   PMID:33473114   PMID:33795686   PMID:34033822   PMID:34383890   PMID:34423345   PMID:34903763   PMID:35951005   PMID:37298722   PMID:38355793  
PMID:38386912   PMID:38509075   PMID:39025297   PMID:39052671  


Genomics

Comparative Map Data
Pitx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391355,972,857 - 55,984,002 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1355,972,864 - 55,984,005 (-)EnsemblGRCm39 Ensembl
GRCm381355,825,044 - 55,836,190 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1355,825,051 - 55,836,192 (-)EnsemblGRCm38mm10GRCm38
MGSCv371355,926,415 - 55,932,786 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361355,834,676 - 55,841,047 (-)NCBIMGSCv36mm8
Celera1356,876,993 - 56,883,263 (-)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1330.06NCBI
PITX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385135,027,734 - 135,034,789 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5135,027,734 - 135,034,813 (-)EnsemblGRCh38hg38GRCh38
GRCh375134,363,424 - 134,369,918 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365134,391,323 - 134,397,863 (-)NCBINCBI36Build 36hg18NCBI36
Build 345134,391,367 - 134,397,887NCBI
Celera5130,487,209 - 130,493,751 (-)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5129,551,412 - 129,557,483 (-)NCBIHuRef
CHM1_15133,796,087 - 133,802,610 (-)NCBICHM1_1
T2T-CHM13v2.05135,554,747 - 135,561,804 (-)NCBIT2T-CHM13v2.0
Pitx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,794,051 - 8,805,477 (+)NCBIGRCr8
mRatBN7.2178,794,134 - 8,800,292 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,794,134 - 8,800,291 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx178,809,236 - 8,815,392 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01710,341,815 - 10,347,973 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0178,805,619 - 8,811,775 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,873,184 - 8,884,428 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,878,270 - 8,884,423 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01711,038,827 - 11,050,071 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41714,834,144 - 14,840,303 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11714,834,143 - 14,840,302 (+)NCBI
Celera178,876,388 - 8,882,546 (+)NCBICelera
Cytogenetic Map17p14NCBI
Pitx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540830,197,061 - 30,203,054 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540830,197,374 - 30,202,887 (-)NCBIChiLan1.0ChiLan1.0
PITX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24130,319,178 - 130,324,814 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15128,458,793 - 128,464,033 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05130,422,920 - 130,429,828 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15136,565,285 - 136,570,346 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5136,565,285 - 136,570,350 (-)Ensemblpanpan1.1panPan2
PITX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11123,069,731 - 23,075,085 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1123,069,716 - 23,080,941 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1121,819,266 - 21,824,629 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01123,876,327 - 23,881,033 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1123,875,377 - 23,887,094 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11122,575,479 - 22,580,842 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01122,441,426 - 22,446,796 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01123,084,230 - 23,089,593 (-)NCBIUU_Cfam_GSD_1.0
Pitx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213123,186,180 - 123,192,158 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365972,211,080 - 2,217,071 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365972,211,087 - 2,217,065 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PITX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2137,200,423 - 137,206,979 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12137,200,424 - 137,212,500 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PITX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12337,807,486 - 37,820,540 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2337,807,378 - 37,813,948 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603440,096,580 - 40,108,540 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pitx1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473312,029,298 - 12,034,413 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473312,028,497 - 12,034,612 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pitx1
378 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:728
Count of miRNA genes:424
Interacting mature miRNAs:521
Transcripts:ENSMUST00000021968, ENSMUST00000173618
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300561Heal7_mwound healing/regeneration 7 (mouse)Not determined133614482070144904Mouse
1301015Sysbp2_msystolic blood pressure 2 (mouse)Not determined132047761259821605Mouse
4142331Bxs6_mBXSB/MpJ autoimmune nephritis 6 (mouse)Not determined4521044283744746Mouse
12738439Twq4_mtestis weight QTL 4 (mouse)133112911065129110Mouse
4142009Pregq3_mpregnancy QTL 3 (mouse)Not determined132061551272385189Mouse
1357587Pfat3_mpredicted fat percentage 3 (mouse)Not determined133610153070101640Mouse
10401111Pgia40_mproteoglycan induced arthritis 40 (mouse)Not determined132791846961918560Mouse
1300573Elsgp2_melevated serum gp70 2 (mouse)Not determined135061682884617027Mouse
10412109Bxs7_mBXSB/MpJ autoimmune nephritis 7 (mouse)Not determined134521044283744746Mouse
10412235Scgq5_mspontaneous crescentic glomerulonephritis QTL 5 (mouse)Not determined133606090896239162Mouse
4142314Tailaq3_mtail length adjusted QTL 3 (mouse)Not determined55720354112431103Mouse
4141992W6q16_mweight 6 weeks QTL 16 (mouse)Not determined55720354112431103Mouse
10755517Chol15_mcholesterol 15 (mouse)133096946764969467Mouse
4142372Moo2_mmodifier of Odc2 (mouse)Not determinedX5031841184318559Mouse
15039353Nmrs35_mNAFLD-associated magnetic resonance shift 35 (mouse)134058825374588253Mouse
1302157Bwem2_mbody weight day 30 males 2 (mouse)Not determined133962924973629397Mouse
4142241Tailq3_mtail length QTL 3 (mouse)Not determined55720354112431103Mouse
1301299Sluc23_msusceptibility to lung cancer 23 (mouse)Not determined133492194368922081Mouse
4140959W10q17_mweight 10 weeks QTL 17 (mouse)Not determined55720354112431103Mouse
4142489Ath25_matherosclerosis 25 (mouse)Not determined2583652959836529Mouse
10755533Chol18_mcholesterol 18 (mouse)133096946764969467Mouse
1300985Bmd13_mbone mineral density 13 (mouse)Not determined133962924973629397Mouse
1302073Pgct1_mprimordial germ cell tumor locus 1 (mouse)Not determined135382078387820897Mouse
10045621Heal21_mwound healing/regeneration 21 (mouse)Not determined132821737962217515Mouse
1300862Cfbw5_mcystic fibrosis body weight 5 (mouse)Not determined133872035872720517Mouse
1300668Pas10_mpulmonary adenoma susceptibility 10 (mouse)Not determined134148904275489158Mouse
1357563Bmch6_mbone mechanical trait 6 (mouse)Not determined135538498089385140Mouse
1301666Eae13_msusceptibility to experimental allergic encephalomyelitis 13 (mouse)Not determined135031841184318559Mouse
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
1300710Pcd4ts2_mp-glycoprotein positive CD4 T cell subset 2 (mouse)Not determined132821044262210544Mouse
1301734Acsns2_mAngiostrongylus costaricensis nematode susceptibility 2 (mouse)Not determined133610153070101640Mouse
26884396Humsd4_mhumerus midshaft diameter 4, 10 week (mouse)134785347673148119Mouse
14696729Kidlq2_mkidney weight, left QTL 2 (mouse)133134473665344736Mouse
1301801Cpfd5_mcerebellum pattern fissures (mouse)Not determined133962924973629397Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
1357802Vtbt15_mvertebral trabecular bone trait 15 (mouse)Not determined132821737962217515Mouse
14746975Manh74_mmandible shape 74 (mouse)135247726986477269Mouse

Markers in Region
U71206  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381355,825,710 - 55,825,816UniSTSGRCm38
MGSCv371355,927,071 - 55,927,177UniSTSGRCm37
Celera1356,877,649 - 56,877,755UniSTS
Cytogenetic Map13B1UniSTS
cM Map1334.0UniSTS
Whitehead/MRC_RH13580.96UniSTS
Pitx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381355,826,337 - 55,826,487UniSTSGRCm38
MGSCv371355,927,698 - 55,927,848UniSTSGRCm37
Celera1356,878,275 - 56,878,425UniSTS
Cytogenetic Map13B1UniSTS
cM Map1334.0UniSTS
cM Map1334.0UniSTS
Pitx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13B1UniSTS
cM Map1334.0UniSTS
Pitx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13B1UniSTS


Sequence


Ensembl Acc Id: ENSMUST00000021968   ⟹   ENSMUSP00000021968
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1355,972,864 - 55,979,238 (-)Ensembl
GRCm38.p6 Ensembl1355,825,051 - 55,831,425 (-)Ensembl
Ensembl Acc Id: ENSMUST00000173618   ⟹   ENSMUSP00000134609
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1355,976,287 - 55,984,005 (-)Ensembl
GRCm38.p6 Ensembl1355,828,474 - 55,836,192 (-)Ensembl
RefSeq Acc Id: NM_011097   ⟹   NP_035227
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391355,972,867 - 55,979,238 (-)NCBI
GRCm381355,825,054 - 55,831,425 (-)NCBI
MGSCv371355,926,415 - 55,932,786 (-)RGD
Celera1356,876,993 - 56,883,263 (-)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006517157   ⟹   XP_006517220
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391355,972,857 - 55,984,002 (-)NCBI
GRCm381355,825,044 - 55,836,190 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006517158   ⟹   XP_006517221
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391355,972,857 - 55,979,138 (-)NCBI
GRCm381355,825,044 - 55,831,324 (-)NCBI
Sequence:
RefSeq Acc Id: NP_035227   ⟸   NM_011097
- UniProtKB: O54742 (UniProtKB/Swiss-Prot),   P70427 (UniProtKB/Swiss-Prot),   P70314 (UniProtKB/Swiss-Prot),   Q3UQH0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006517220   ⟸   XM_006517157
- Peptide Label: isoform X1
- UniProtKB: O54742 (UniProtKB/Swiss-Prot),   P70427 (UniProtKB/Swiss-Prot),   P70314 (UniProtKB/Swiss-Prot),   Q3UQH0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006517221   ⟸   XM_006517158
- Peptide Label: isoform X1
- UniProtKB: O54742 (UniProtKB/Swiss-Prot),   P70427 (UniProtKB/Swiss-Prot),   P70314 (UniProtKB/Swiss-Prot),   Q3UQH0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000134609   ⟸   ENSMUST00000173618
Ensembl Acc Id: ENSMUSP00000021968   ⟸   ENSMUST00000021968
Protein Domains
Homeobox   OAR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70314-F1-model_v2 AlphaFold P70314 1-315 view protein structure

Promoters
RGD ID:8680486
Promoter ID:EPDNEW_M18274
Type:initiation region
Name:Pitx1_1
Description:Mus musculus paired-like homeodomain transcription factor 1 ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M18275  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381355,831,240 - 55,831,300EPDNEW
RGD ID:8680488
Promoter ID:EPDNEW_M18275
Type:multiple initiation site
Name:Pitx1_2
Description:Mus musculus paired-like homeodomain transcription factor 1 ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M18274  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381355,831,388 - 55,831,448EPDNEW
RGD ID:6848627
Promoter ID:MM_TRO:2542
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:MTR007232.13.1096.2
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361355,927,856 - 55,928,356 (-)MPROMDB
RGD ID:6847053
Promoter ID:MM_ACW:13414
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Lung
Transcripts:PITX1.ASEP07,   PITX1.DSEP07-UNSPLICED,   PITX1.ESEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361355,936,714 - 55,937,214 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107374 AgrOrtholog
Ensembl Genes ENSMUSG00000021506 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000021968 ENTREZGENE
  ENSMUST00000021968.7 UniProtKB/Swiss-Prot
  ENSMUST00000173618.2 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_Pitx/unc30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OAR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18740 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:107374 ENTREZGENE
NCBI Gene 18740 ENTREZGENE
PANTHER PITUITARY HOMEOBOX 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PITUITARY HOMEOBOX HOMOLOG PTX1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pitx1 PhenoGen
PIRSF Homeobox_protein_Pitx/Unc30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3UZS0_MOUSE UniProtKB/TrEMBL
  O54742 ENTREZGENE
  P70314 ENTREZGENE
  P70427 ENTREZGENE
  PITX1_MOUSE UniProtKB/Swiss-Prot
  Q3UQH0 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary O54742 UniProtKB/Swiss-Prot
  P70427 UniProtKB/Swiss-Prot