Trp63 (transformation related protein 63) - Rat Genome Database

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Gene: Trp63 (transformation related protein 63) Mus musculus
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Symbol: Trp63
Name: transformation related protein 63
RGD ID: 736710
MGI Page MGI
Description: Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and promoter-specific chromatin binding activity. Involved in several processes, including establishment of skin barrier; negative regulation of intracellular estrogen receptor signaling pathway; and regulation of epidermal cell division. Acts upstream of or within several processes, including embryonic morphogenesis; epithelial cell differentiation; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; sensory organ; and surface ectoderm. Used to study ankyloblepharon-ectodermal defects-cleft lip/palate syndrome; bladder exstrophy; ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3; and gastroesophageal reflux disease. Human ortholog(s) of this gene implicated in several diseases, including ADULT syndrome; EEC syndrome (multiple); ectodermal dysplasia (multiple); orofacial cleft 8; and split hand-foot malformation 4. Orthologous to human TP63 (tumor protein p63).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AI462811; delta; Ket; MGC115972; p51/p; P51/P63; p6; P63; p7; P73l; TAp; Tp63; transformation-related protein 63; Trp5; Trp53rp1; tumor protein 63; tumor protein p73-like
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391625,502,513 - 25,710,842 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1625,502,513 - 25,710,852 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381625,683,763 - 25,892,088 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1625,683,763 - 25,892,102 (+)Ensemblmm10GRCm38
MGSCv371625,683,851 - 25,892,174 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361625,717,291 - 25,807,429 (+)NCBIMGSCv36mm8
Celera1626,227,614 - 26,435,704 (+)NCBICelera
Cytogenetic Map16B1NCBI
cM Map1617.37NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
adenocarcinoma  (ISO)
ADULT syndrome  (ISO)
amenorrhea  (ISO)
Ankyloblepharon Filiforme Adnatum  (ISO)
ankyloblepharon-ectodermal defects-cleft lip/palate syndrome  (IAGP,ISO)
Auditory Neuropathy  (ISO)
bladder exstrophy  (IAGP)
bladder exstrophy-epispadias-cloacal exstrophy complex  (ISO)
breast disease  (ISO)
Breast Neoplasms  (EXP)
carcinoma  (ISO)
cervix uteri carcinoma in situ  (ISO)
cleft lip  (ISO)
Cleft Lip with or without Cleft Palate, Nonsyndromic, 8  (ISO)
cleft palate  (ISO)
Colorectal Neoplasms  (ISO)
Congenital Foot Deformities  (ISO)
Congenital Hand Deformities  (ISO)
Congenital Limb Deformities  (ISO)
Corneal Injuries  (IEP)
Craniofacial Abnormalities  (ISO)
ectodermal dysplasia  (ISO)
ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3  (IAGP,ISO)
EEC syndrome  (IMP,ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Neoplasms  (EXP)
Female Urogenital Diseases  (ISO)
fissured tongue  (ISO)
gastroesophageal reflux disease  (IAGP)
genetic disease  (ISO)
Limb-Mammary Syndrome  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
Lung Neoplasms  (ISO)
Multiple Abnormalities  (ISO)
muscular dystrophy  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
orofacial cleft 8  (ISO)
osteochondrodysplasia  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
primary ovarian insufficiency  (ISO)
Primary Ovarian Insufficiency 21  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (EXP,IEP,ISO)
Prostatic Neoplasms  (EXP,IEP,ISO)
Rapp-Hodgkin syndrome  (ISO)
schizophrenia  (ISO)
Skin Abnormalities  (ISO)
spermatogenic failure 5  (ISO)
split hand-foot malformation  (ISO)
split hand-foot malformation 4  (ISO)
squamous cell carcinoma  (ISO)
squamous cell neoplasm  (ISO)
Sweat Gland Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
Urologic Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-naringenin  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dibromoethane  (EXP)
1,2-dichloroethane  (EXP)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,4-dichloroaniline  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (ISO)
4-vinylcyclohexene dioxide  (EXP)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (ISO)
ammonium chloride  (ISO)
amphotericin B  (ISO)
antimonite  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
butan-1-ol  (ISO)
butane-2,3-dione  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chloropicrin  (ISO)
chrysin  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
D-glucose  (EXP)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (EXP)
diiodine  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
emodin  (EXP)
entinostat  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
ethylenediaminetetraacetic acid  (ISO)
eugenol  (ISO)
Evodiamine  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
Fusarenone X  (EXP)
genistein  (ISO)
glucose  (EXP)
glycidol  (EXP)
glyphosate  (EXP)
graphite  (EXP)
hydroxyurea  (EXP)
isobutanol  (ISO)
kaempferol  (ISO)
ketoconazole  (EXP)
lactacystin  (ISO)
lead diacetate  (EXP)
leptomycin B  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
luteolin  (ISO)
melphalan  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
myricetin  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nickel dichloride  (ISO)
Octicizer  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
progesterone  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
quinolin-8-ol  (EXP)
rac-lactic acid  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (EXP)
sodium arsenite  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
troglitazone  (ISO)
urethane  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure formation involved in morphogenesis  (IMP)
animal organ morphogenesis  (IMP)
apoptotic process  (IEA,TAS)
cellular senescence  (IMP)
chromatin remodeling  (IMP)
cloacal septation  (IMP)
cranial skeletal system development  (IMP)
determination of adult lifespan  (IMP)
digestive tract morphogenesis  (IEA)
DNA damage response  (ISO)
ectoderm and mesoderm interaction  (IMP)
embryonic forelimb morphogenesis  (IMP)
embryonic hindlimb morphogenesis  (IMP)
embryonic limb morphogenesis  (IGI,IMP)
epidermal cell differentiation  (IMP)
epidermal cell division  (IMP)
epidermis development  (IMP)
epithelial cell development  (IMP)
epithelial cell differentiation  (IMP)
establishment of planar polarity  (IDA)
establishment of skin barrier  (IMP)
female genitalia morphogenesis  (IMP)
hair follicle development  (IMP)
hair follicle morphogenesis  (IMP)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (IBA,IEA,IMP)
keratinocyte differentiation  (IDA)
keratinocyte proliferation  (IGI)
morphogenesis of a polarized epithelium  (IMP)
negative regulation of cellular senescence  (ISO)
negative regulation of DNA-templated transcription  (IEA,ISO)
negative regulation of intracellular estrogen receptor signaling pathway  (IMP)
negative regulation of keratinocyte differentiation  (IMP)
negative regulation of mesoderm development  (IMP)
negative regulation of transcription by RNA polymerase II  (IDA)
neuron apoptotic process  (IMP)
Notch signaling pathway  (IEA,IMP)
odontogenesis of dentin-containing tooth  (IMP)
pattern specification process  (IMP)
polarized epithelial cell differentiation  (IMP)
positive regulation of apoptotic signaling pathway  (IDA,IEA)
positive regulation of cell cycle G1/S phase transition  (ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of fibroblast apoptotic process  (IEA,ISO)
positive regulation of keratinocyte proliferation  (IGI)
positive regulation of Notch signaling pathway  (IEA,IMP,ISO)
positive regulation of osteoblast differentiation  (IEA,ISO)
positive regulation of somatic stem cell population maintenance  (IMP)
positive regulation of stem cell proliferation  (IGI)
positive regulation of transcription by RNA polymerase II  (IBA,IDA,IEA,IMP,ISO)
post-anal tail morphogenesis  (IMP)
prostate gland development  (IMP)
prostatic bud formation  (IMP)
protein tetramerization  (IEA)
proximal/distal pattern formation  (IMP)
regulation of apoptotic process  (IBA)
regulation of DNA-templated transcription  (IEA)
regulation of epidermal cell division  (IMP)
skeletal system development  (IMP)
skin epidermis development  (IMP)
skin morphogenesis  (IMP)
spermatogenesis  (IEA,ISO)
squamous basal epithelial stem cell differentiation involved in prostate gland acinus development  (IMP)
stem cell differentiation  (IMP)
stem cell proliferation  (IGI,IMP)
sympathetic nervous system development  (IMP)
transcription by RNA polymerase II  (IDA,IMP)

Cellular Component
chromatin  (IBA,IEA,ISO)
cytoplasm  (IEA,ISO)
dendrite  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IDA,IEA,ISO)
protein-containing complex  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal abdominal wall morphology  (IAGP)
abnormal anus morphology  (IAGP)
abnormal apical ectodermal ridge morphology  (IAGP)
abnormal cellular replicative senescence  (IAGP)
abnormal cornea epithelium morphology  (IAGP)
abnormal craniofacial development  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal ectoderm development  (IAGP)
abnormal embryo development  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal epidermis stratum basale morphology  (IAGP)
abnormal epidermis stratum spinosum morphology  (IAGP)
abnormal esophageal epithelium morphology  (IAGP)
abnormal esophageal squamous epithelium morphology  (IAGP)
abnormal esophagus development  (IAGP)
abnormal eye morphology  (IAGP)
abnormal facial morphology  (IAGP)
abnormal female reproductive system morphology  (IAGP)
abnormal forelimb morphology  (IAGP)
abnormal hair follicle development  (IAGP)
abnormal hair shaft morphology  (IAGP)
abnormal horizontal basal cell of olfactory epithelium morphology  (IAGP)
abnormal humerus morphology  (IAGP)
abnormal keratinocyte differentiation  (IAGP)
abnormal keratinocyte morphology  (IAGP)
abnormal keratinocyte physiology  (IAGP)
abnormal limb bone morphology  (IAGP)
abnormal limb bud morphology  (IAGP)
abnormal limb development  (IAGP)
abnormal limb morphology  (IAGP)
abnormal mitochondrial physiology  (IAGP)
abnormal olfactory epithelium morphology  (IAGP)
abnormal olfactory gland morphology  (IAGP)
abnormal palatal shelf fusion at midline  (IAGP)
abnormal pelvic girdle bone morphology  (IAGP)
abnormal periderm morphology  (IAGP)
abnormal phalanx morphology  (IAGP)
abnormal primitive urogenital sinus morphology  (IAGP)
abnormal prostate gland branching morphogenesis  (IAGP)
abnormal rectum morphology  (IAGP)
abnormal reproductive system morphology  (IAGP)
abnormal respiratory epithelium morphology  (IAGP)
abnormal secondary palate development  (IAGP)
abnormal septation of the cloaca  (IAGP)
abnormal skin condition  (IAGP)
abnormal skin development  (IAGP)
abnormal skin morphology  (IAGP)
abnormal skin physiology  (IAGP)
abnormal stomach epithelium morphology  (IAGP)
abnormal stomach non-glandular epithelium morphology  (IAGP)
abnormal tongue epithelium morphology  (IAGP)
abnormal tooth development  (IAGP)
abnormal tooth root morphology  (IAGP)
abnormal tracheal ciliated epithelium morphology  (IAGP)
abnormal urinary bladder detrusor smooth muscle morphology  (IAGP)
abnormal urinary bladder urothelium morphology  (IAGP)
abnormal uterine cervix epithelium morphology  (IAGP)
abnormal vagina epithelium morphology  (IAGP)
abnormal ventral body wall morphology  (IAGP)
absent apical ectodermal ridge  (IAGP)
absent carpal bone  (IAGP)
absent epidermis  (IAGP)
absent epidermis stratum corneum  (IAGP)
absent epidermis stratum granulosum  (IAGP)
absent epidermis stratum spinosum  (IAGP)
absent eyelids  (IAGP)
absent gastric milk in neonates  (IAGP)
absent hair follicles  (IAGP)
absent hindlimb  (IAGP)
absent lacrimal glands  (IAGP)
absent mammary gland  (IAGP)
absent ovary  (IAGP)
absent oviduct  (IAGP)
absent prostate gland  (IAGP)
absent pubic symphysis  (IAGP)
absent radius  (IAGP)
absent salivary gland  (IAGP)
absent sebaceous gland  (IAGP)
absent teeth  (IAGP)
absent tongue squamous epithelium  (IAGP)
absent tooth placode  (IAGP)
absent ulna  (IAGP)
absent urinary bladder urothelium  (IAGP)
absent vibrissae  (IAGP)
acanthosis  (IAGP)
adactyly  (IAGP)
alopecia  (IAGP)
aneuploidy  (IAGP)
blistering  (IAGP)
chromosomal instability  (IAGP)
circling  (IAGP)
cleft palate  (IAGP)
clitoris hypoplasia  (IAGP)
decreased apoptosis  (IAGP)
decreased cell proliferation  (IAGP)
decreased cellular sensitivity to ionizing radiation  (IAGP)
decreased fetal size  (IAGP)
decreased hair follicle number  (IAGP)
decreased keratinocyte proliferation  (IAGP)
decreased limb number  (IAGP)
dehydration  (IAGP)
dermal-epidermal separation  (IAGP)
distended abdomen  (IAGP)
distended urinary bladder  (IAGP)
early cellular replicative senescence  (IAGP)
ectrodactyly  (IAGP)
embryonic lethality, incomplete penetrance  (IAGP)
enlarged lymph nodes  (IAGP)
esophagogastric junction metaplasia  (IAGP)
gastric cyst  (IAGP)
gastric metaplasia  (IAGP)
hemorrhage  (IAGP)
impaired skin barrier function  (IAGP)
impaired wound healing  (IAGP)
increased apoptosis  (IAGP)
increased carcinoma incidence  (IAGP)
increased chronic myelocytic leukemia incidence  (IAGP)
increased hemangiosarcoma incidence  (IAGP)
increased histiocytic sarcoma incidence  (IAGP)
increased lung adenocarcinoma incidence  (IAGP)
increased lung adenoma incidence  (IAGP)
increased malignant tumor incidence  (IAGP)
increased mammary adenocarcinoma incidence  (IAGP)
increased metastatic potential  (IAGP)
increased osteosarcoma incidence  (IAGP)
increased rhabdomyosarcoma incidence  (IAGP)
increased salivary gland adenoma incidence  (IAGP)
increased squamous cell carcinoma incidence  (IAGP)
increased susceptibility to infection  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
increased tumor incidence  (IAGP)
increased urinary bladder transitional cell carcinoma incidence  (IAGP)
intervertebral disk degeneration  (IAGP)
kidney cyst  (IAGP)
kidney inflammation  (IAGP)
kyphosis  (IAGP)
lordokyphosis  (IAGP)
monodactyly  (IAGP)
nail dystrophy  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
paralysis  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
premature aging  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IEA)
preweaning lethality, incomplete penetrance  (IAGP)
rectal prolapse  (IAGP)
rectovaginal fistula  (IAGP)
ruffled hair  (IAGP)
shiny skin  (IAGP)
short forelimb  (IAGP)
short limbs  (IAGP)
skin lesions  (IAGP)
small limb buds  (IAGP)
small mandible  (IAGP)
small maxilla  (IAGP)
small tail bud  (IAGP)
small uterus  (IAGP)
spontaneous skin ulceration  (IAGP)
supernumerary teeth  (IAGP)
syndactyly  (IAGP)
thick dermal layer  (IAGP)
thick epidermis  (IAGP)
thick epidermis stratum basale  (IAGP)
thick epidermis stratum spinosum  (IAGP)
thin urinary bladder urothelium  (IAGP)
translucent skin  (IAGP)
umbilical hernia  (IAGP)
urinary bladder exstrophy  (IAGP)
uterine cervix inflammation  (IAGP)
weakness  (IAGP)
weight loss  (IAGP)
wrinkled skin  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. A novel c.1037C > G (p.Ala346Gly) mutation in TP63 as cause of the ectrodactyly-ectodermal dysplasia and cleft lip/palate (EEC) syndrome. Alves LU, etal., Genet Mol Biol. 2015 Mar;38(1):37-41. doi: 10.1590/S1415-475738120140125. Epub 2014 Mar 17.
2. Proliferation and apoptotic rates and increased frequency of p63-positive cells in the prostate acinar epithelium of alloxan-induced diabetic rats. Arcolino FO, etal., Int J Exp Pathol. 2010 Apr;91(2):144-54. doi: 10.1111/j.1365-2613.2009.00696.x. Epub 2009 Dec 22.
3. Analysis of the p63 gene in classical EEC syndrome, related syndromes, and non-syndromic orofacial clefts. Barrow LL, etal., J Med Genet. 2002 Aug;39(8):559-66.
4. Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome. Celli J, etal., Cell. 1999 Oct 15;99(2):143-53.
5. Molecular basis of EEC (ectrodactyly, ectodermal dysplasia, clefting) syndrome: five new mutations in the DNA-binding domain of the TP63 gene and genotype-phenotype correlation. Clements SE, etal., Br J Dermatol. 2010 Jan;162(1):201-7. doi: 10.1111/j.1365-2133.2009.09496.x. Epub 2009 Nov 9.
6. Clinical Variability in a Family with an Ectodermal Dysplasia Syndrome and a Nonsense Mutation in the TP63 Gene. Eisenkraft A, etal., Fetal Pediatr Pathol. 2015;34(6):400-6. doi: 10.3109/15513815.2015.1095261. Epub 2015 Oct 16.
7. Mutant p53: one name, many proteins. Freed-Pastor WA and Prives C, Genes Dev. 2012 Jun 15;26(12):1268-86. doi: 10.1101/gad.190678.112.
8. Impaired delta NP63 expression is associated with poor tumor development in transitional cell carcinoma of the bladder. He Y, etal., J Korean Med Sci. 2008 Oct;23(5):825-32.
9. Periacinar Clefting and p63 Immunostaining in Prostatic Intraepithelial Neoplasia and Prostatic Carcinoma. Kruslin B, etal., Pathol Oncol Res. 2006;12(4):205-9. Epub 2006 Dec 25.
10. DeltaNp63 protein expression in uterine cervical and endometrial cancers. Lin Z, etal., J Cancer Res Clin Oncol. 2006 Dec;132(12):811-6. Epub 2006 Jun 28.
11. DeltaNp63 expression is associated with poor survival in ovarian cancer. Marchini S, etal., Ann Oncol. 2008 Mar;19(3):501-7. Epub 2007 Nov 12.
12. Hay-Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63. McGrath JA, etal., Hum Mol Genet. 2001 Feb 1;10(3):221-9.
13. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
14. MGDs mouse GO annotations MGD data from the GO Consortium
15. MGD IEA MGD IEA
16. The corneal epithelial stem cell. Moore JE, etal., DNA Cell Biol. 2002 May-Jun;21(5-6):443-51.
17. p53 mutations in cancer. Muller PA and Vousden KH, Nat Cell Biol. 2013 Jan;15(1):2-8. doi: 10.1038/ncb2641.
18. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. TP63 mutation and clefting modifier genes in an EEC syndrome family. Ray AK, etal., Clin Genet. 2004 Sep;66(3):217-22.
21. Progression of prostate cancer from a subset of p63-positive basal epithelial cells in FG/Tag transgenic mice. Reiner T, etal., Mol Cancer Res. 2007 Nov;5(11):1171-9. Epub 2007 Nov 2.
22. Mouse MP Annotation Import Pipeline RGD automated import pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. EEC (Ectrodactyly, Ectodermal dysplasia, Clefting) syndrome: heterozygous mutation in the p63 gene (R279H) and DNA-based prenatal diagnosis. South AP, etal., Br J Dermatol. 2002 Feb;146(2):216-20.
26. E-cadherin and p63 immunoexpression in dysplastic lesions and urothelial carcinomas of the bladder. Stepan A, etal., Rom J Morphol Embryol. 2009;50(3):461-5.
27. Anorectal malformation associated with a mutation in the P63 gene in a family with split hand-foot malformation. Su P, etal., Int J Colorectal Dis. 2013 Dec;28(12):1621-7. doi: 10.1007/s00384-013-1725-6. Epub 2013 Jun 5.
28. Diagnostic and prognostic impact of p63 immunoreactivity in renal malignancies. Tuna B, etal., Anal Quant Cytol Histol. 2009 Apr;31(2):118-22.
29. p63 Gene mutations in eec syndrome, limb-mammary syndrome, and isolated split hand-split foot malformation suggest a genotype-phenotype correlation. van Bokhoven H, etal., Am J Hum Genet. 2001 Sep;69(3):481-92. Epub 2001 Jul 17.
30. An allelic series of Trp63 mutations defines TAp63 as a modifier of EEC syndrome. Vernersson Lindahl E, etal., Am J Med Genet A. 2013 Aug;161A(8):1961-71. doi: 10.1002/ajmg.a.36074. Epub 2013 Jun 14.
31. Integrating expression-related SNPs into genome-wide gene- and pathway-based analyses identified novel lung cancer susceptibility genes. Wang Y, etal., Int J Cancer. 2018 Apr 15;142(8):1602-1610. doi: 10.1002/ijc.31182. Epub 2017 Dec 12.
32. Analysis of large phenotypic variability of EEC and SHFM4 syndromes caused by K193E mutation of the TP63 gene. Wei J, etal., PLoS One. 2012;7(5):e35337. doi: 10.1371/journal.pone.0035337. Epub 2012 May 4.
33. Insertion/deletion polymorphisms in the DeltaNp63 promoter are a risk factor for bladder exstrophy epispadias complex. Wilkins S, etal., PLoS Genet. 2012;8(12):e1003070. doi: 10.1371/journal.pgen.1003070. Epub 2012 Dec 20.
34. TP63 gene mutations in Chinese P63 syndrome patients. Yin W, etal., J Dent Res. 2010 Aug;89(8):813-7. doi: 10.1177/0022034510366804. Epub 2010 Apr 21.
Additional References at PubMed
PMID:9315105   PMID:9703973   PMID:9774969   PMID:9799841   PMID:10203277   PMID:10227293   PMID:10227294   PMID:10231571   PMID:10349636   PMID:10657951   PMID:10754563   PMID:11042159  
PMID:11076861   PMID:11106548   PMID:11118893   PMID:11217851   PMID:11470269   PMID:11522642   PMID:11733180   PMID:11747081   PMID:11825686   PMID:11857801   PMID:11932750   PMID:12368184  
PMID:12368193   PMID:12477932   PMID:12702649   PMID:12789272   PMID:12941620   PMID:12951416   PMID:14526104   PMID:14555234   PMID:14729569   PMID:14757276   PMID:14998922   PMID:15033906  
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PMID:15659035   PMID:15716346   PMID:15746257   PMID:15797384   PMID:15837625   PMID:15908775   PMID:15922574   PMID:15982302   PMID:15987773   PMID:15988020   PMID:16007124   PMID:16007185  
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Genomics

Comparative Map Data
Trp63
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391625,502,513 - 25,710,842 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1625,502,513 - 25,710,852 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381625,683,763 - 25,892,088 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1625,683,763 - 25,892,102 (+)Ensemblmm10GRCm38
MGSCv371625,683,851 - 25,892,174 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361625,717,291 - 25,807,429 (+)NCBIMGSCv36mm8
Celera1626,227,614 - 26,435,704 (+)NCBICelera
Cytogenetic Map16B1NCBI
cM Map1617.37NCBI
TP63
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383189,596,746 - 189,897,276 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3189,631,389 - 189,897,276 (+)Ensemblhg38GRCh38
GRCh373189,314,535 - 189,615,065 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363190,831,910 - 191,097,759 (+)NCBIBuild 36Build 36hg18NCBI36
Celera3187,783,803 - 188,042,610 (+)NCBICelera
Cytogenetic Map3q28NCBI
HuRef3186,752,882 - 187,012,887 (+)NCBIHuRef
CHM1_13189,312,090 - 189,577,623 (+)NCBICHM1_1
T2T-CHM13v2.03192,413,470 - 192,713,713 (+)NCBIT2T-CHM13v2.0
Tp63
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81188,343,647 - 88,554,543 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1188,343,651 - 88,554,177 (-)EnsemblGRCr8
mRatBN7.21174,838,858 - 75,049,764 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1174,838,859 - 75,049,398 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1183,648,386 - 83,858,432 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01176,283,447 - 76,493,481 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01175,342,697 - 75,553,279 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01178,234,853 - 78,456,559 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1178,234,800 - 78,456,501 (-)Ensemblrn6Rnor6.0
Rnor_5.01182,262,234 - 82,484,354 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41176,900,622 - 77,200,251 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1173,744,494 - 73,953,104 (-)NCBICelera
RGSC_v3.11176,958,211 - 77,257,840 (-)NCBI
Cytogenetic Map11q22NCBI
Tp63
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542018,176,155 - 18,384,786 (-)Ensembl
ChiLan1.0NW_00495542018,178,639 - 18,384,786 (-)NCBIChiLan1.0ChiLan1.0
TP63
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22187,462,332 - 187,762,966 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13187,467,050 - 187,767,682 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03186,651,879 - 186,918,300 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13195,172,810 - 195,473,085 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3195,199,167 - 195,474,104 (+)EnsemblpanPan2panpan1.1
TP63
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13421,766,861 - 21,985,095 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3421,766,496 - 21,983,046 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3425,860,495 - 26,078,655 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03421,700,749 - 21,919,495 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3421,700,663 - 21,918,660 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13421,716,204 - 21,934,749 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03421,710,660 - 21,927,985 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03421,951,749 - 22,170,136 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tp63
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602114,397,903 - 114,613,831 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936578491,507 - 705,729 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936578492,267 - 705,282 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TP63
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13127,116,105 - 127,347,068 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113127,115,990 - 127,347,082 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213136,309,804 - 136,515,766 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TP63
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11583,861,489 - 84,126,675 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604157,444,595 - 57,708,553 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tp63
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473067,286,160 - 67,489,670 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473067,283,444 - 67,489,808 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Trp63
7045 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:5110
Count of miRNA genes:794
Interacting mature miRNAs:1093
Transcripts:ENSMUST00000040231, ENSMUST00000065523, ENSMUST00000115304, ENSMUST00000115305, ENSMUST00000115306, ENSMUST00000115307, ENSMUST00000115308, ENSMUST00000115310
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
1301841Lrnx9_mlearning-contextual 9 (mouse)Not determined161222536046225471Mouse
4142460Nilac10_mnicotine induced locomotor activity 10 (mouse)Not determined16713690629225471Mouse
4141179Ipng3_mimprinted postnatal growth 3 (mouse)Not determined2277525257594076Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16431786444520363Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
11565820Vasr1_mvariability in acoustic startle response 1 (mouse)161969865726368664Mouse
1301086Lprm5_mlymphoproliferation modifier 5 (mouse)Not determined161184882445848923Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16331786451420363Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16464631438646414Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined16988163143881631Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16654297965466552Mouse
1357517Bwtn1_mbody weight at necropsy 1 (mouse)Not determined162001932985600826Mouse
1301384Dice1_mdetermination of interleukin 4 commitment 1 (mouse)Not determined16128434358Mouse
1300943Skts9_mskin tumor susceptibility 9 (mouse)Not determined16577525239775440Mouse
10402497Lmr23_mleishmaniasis resistance 23 (mouse)Not determined16129674200Mouse
10412289Ppsl_mplasma P-selectin levels (mouse)Not determined16130814572Mouse
1300656Bgeq15_mbody growth early QTL 15 (mouse)Not determined16577525239775440Mouse
4142236Pstc4_mperiosteal circumference 4 (mouse)Not determined161552290949523112Mouse
1301559Bbaa19_mB.burgdorferi-associated arthritis 19 (mouse)Not determined16130066977Mouse
1300534Bmd15_mbone mineral density 15 (mouse)Not determined162193838355938574Mouse
11251724Ewc6_methanol withdrawal and consumption 6 (mouse)16822605242226052Mouse
1300987Skull23_mskull morphology 23 (mouse)Not determined16577525239775440Mouse
1301945Skl7_mskeletal size (tail length) 7 (mouse)Not determined16577525239775440Mouse
4141010Bbq1_mbrain and behavior QTL 1 (mouse)Not determined16647700935021216Mouse
10045614Rapop6_mradiation-induced apoptosis 6 (mouse)Not determined161480292148803032Mouse
15092062Egrme4_mearly growth rate, maternal effect 4 (mouse)162521866444220250Mouse
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16331786439820362Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse

Markers in Region
AI462811  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381625,891,676 - 25,891,759UniSTSGRCm38
MGSCv371625,891,762 - 25,891,845UniSTSGRCm37
Celera1626,435,292 - 26,435,375UniSTS
Cytogenetic Map16B1UniSTS
cM Map1619.3UniSTS
Whitehead/MRC_RH16220.27UniSTS
31.MMHAP58FLC4.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381625,784,079 - 25,784,278UniSTSGRCm38
MGSCv371625,784,165 - 25,784,364UniSTSGRCm37
Celera1626,327,938 - 26,328,137UniSTS
Cytogenetic Map16B1UniSTS
cM Map1619.3UniSTS
Whitehead_YAC16 UniSTS
Trp63  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371625,868,269 - 25,871,183UniSTSGRCm37
MGSCv371625,865,002 - 25,865,211UniSTSGRCm37
Celera1626,408,532 - 26,408,741UniSTS
Celera1626,411,799 - 26,414,713UniSTS
Cytogenetic Map16B1UniSTS
cM Map1619.3UniSTS
cM Map1619.3UniSTS
cM Map1619.3UniSTS
cM Map1619.3UniSTS
AB010152  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381625,890,490 - 25,890,611UniSTSGRCm38
MGSCv371625,890,576 - 25,890,697UniSTSGRCm37
Celera1626,434,106 - 26,434,227UniSTS
Cytogenetic Map16B1UniSTS
cM Map1619.3UniSTS
Whitehead/MRC_RH16221.52UniSTS
Trp63  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16B1UniSTS
Trp63  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16B1UniSTS
Trp63  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16B1UniSTS
Trp63  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16B1UniSTS
Trp63  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16B1UniSTS
cM Map1619.3UniSTS
Trp63  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381625,864,916 - 25,865,125UniSTSGRCm38
MGSCv371625,865,002 - 25,865,211UniSTSGRCm37
Celera1626,408,532 - 26,408,741UniSTS
Cytogenetic Map16B1UniSTS
cM Map1619.3UniSTS
Trp63  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16B1UniSTS
cM Map1619.3UniSTS
Trp63  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16B1UniSTS
Trp63  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16B1UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001127259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001127260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001127261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001127262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001127263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001127264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001127265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001427037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006522001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006522002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB010152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC109213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC113020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF075434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF075435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF075436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF075437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF075438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF075439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF533892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK047884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK048623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK138305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK140023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK162112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC090649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC092537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000040231   ⟹   ENSMUSP00000038117
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1625,620,666 - 25,710,852 (+)Ensembl
GRCm38.p6 Ensembl1625,801,916 - 25,892,102 (+)Ensembl
Ensembl Acc Id: ENSMUST00000065523   ⟹   ENSMUSP00000067005
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1625,502,515 - 25,710,837 (+)Ensembl
GRCm38.p6 Ensembl1625,683,765 - 25,892,087 (+)Ensembl
Ensembl Acc Id: ENSMUST00000115304   ⟹   ENSMUSP00000110959
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1625,620,666 - 25,686,604 (+)Ensembl
GRCm38.p6 Ensembl1625,801,916 - 25,867,854 (+)Ensembl
Ensembl Acc Id: ENSMUST00000115305   ⟹   ENSMUSP00000110960
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1625,620,666 - 25,695,894 (+)Ensembl
GRCm38.p6 Ensembl1625,801,916 - 25,877,144 (+)Ensembl
Ensembl Acc Id: ENSMUST00000115306   ⟹   ENSMUSP00000110961
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1625,620,666 - 25,710,852 (+)Ensembl
GRCm38.p6 Ensembl1625,801,916 - 25,892,102 (+)Ensembl
Ensembl Acc Id: ENSMUST00000115307   ⟹   ENSMUSP00000110962
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1625,502,513 - 25,640,068 (+)Ensembl
GRCm38.p6 Ensembl1625,683,763 - 25,821,318 (+)Ensembl
Ensembl Acc Id: ENSMUST00000115308   ⟹   ENSMUSP00000110963
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1625,502,515 - 25,695,894 (+)Ensembl
GRCm38.p6 Ensembl1625,683,765 - 25,877,144 (+)Ensembl
Ensembl Acc Id: ENSMUST00000115310   ⟹   ENSMUSP00000110965
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1625,502,515 - 25,710,852 (+)Ensembl
GRCm38.p6 Ensembl1625,683,765 - 25,892,102 (+)Ensembl
RefSeq Acc Id: NM_001127259   ⟹   NP_001120731
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391625,502,515 - 25,710,838 (+)NCBI
GRCm381625,683,765 - 25,892,088 (+)NCBI
MGSCv371625,683,851 - 25,892,174 (+)RGD
Celera1626,227,614 - 26,435,704 (+)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001127260   ⟹   NP_001120732
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391625,502,515 - 25,710,838 (+)NCBI
GRCm381625,683,765 - 25,892,088 (+)NCBI
MGSCv371625,683,851 - 25,892,174 (+)RGD
Celera1626,227,614 - 26,435,704 (+)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001127261   ⟹   NP_001120733
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391625,502,515 - 25,695,894 (+)NCBI
GRCm381625,683,765 - 25,877,144 (+)NCBI
MGSCv371625,683,851 - 25,892,174 (+)RGD
Celera1626,227,614 - 26,435,704 (+)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001127262   ⟹   NP_001120734
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391625,620,666 - 25,710,838 (+)NCBI
GRCm381625,801,916 - 25,892,088 (+)NCBI
MGSCv371625,683,851 - 25,892,174 (+)RGD
Celera1626,227,614 - 26,435,704 (+)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001127263   ⟹   NP_001120735
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391625,620,666 - 25,695,894 (+)NCBI
GRCm381625,801,916 - 25,877,144 (+)NCBI
MGSCv371625,683,851 - 25,892,174 (+)RGD
Celera1626,227,614 - 26,435,704 (+)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001127264   ⟹   NP_001120736
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391625,620,666 - 25,710,838 (+)NCBI
GRCm381625,801,916 - 25,892,088 (+)NCBI
MGSCv371625,683,851 - 25,892,174 (+)RGD
Celera1626,227,614 - 26,435,704 (+)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001127265   ⟹   NP_001120737
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391625,620,666 - 25,695,894 (+)NCBI
GRCm381625,801,916 - 25,877,144 (+)NCBI
MGSCv371625,683,851 - 25,892,174 (+)RGD
Celera1626,227,614 - 26,435,704 (+)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001427037   ⟹   NP_001413966
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391625,502,915 - 25,710,842 (+)NCBI
RefSeq Acc Id: NM_011641   ⟹   NP_035771
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391625,620,666 - 25,710,838 (+)NCBI
GRCm381625,801,916 - 25,892,088 (+)NCBI
MGSCv371625,683,851 - 25,892,174 (+)RGD
Celera1626,227,614 - 26,435,704 (+)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006522001   ⟹   XP_006522064
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391625,620,513 - 25,708,089 (+)NCBI
GRCm381625,801,763 - 25,889,339 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006522002   ⟹   XP_006522065
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391625,502,513 - 25,696,648 (+)NCBI
GRCm381625,683,763 - 25,877,898 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001120731 (Get FASTA)   NCBI Sequence Viewer  
  NP_001120732 (Get FASTA)   NCBI Sequence Viewer  
  NP_001120733 (Get FASTA)   NCBI Sequence Viewer  
  NP_001120734 (Get FASTA)   NCBI Sequence Viewer  
  NP_001120735 (Get FASTA)   NCBI Sequence Viewer  
  NP_001120736 (Get FASTA)   NCBI Sequence Viewer  
  NP_001120737 (Get FASTA)   NCBI Sequence Viewer  
  NP_001413966 (Get FASTA)   NCBI Sequence Viewer  
  NP_035771 (Get FASTA)   NCBI Sequence Viewer  
  XP_006522064 (Get FASTA)   NCBI Sequence Viewer  
  XP_006522065 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC62639 (Get FASTA)   NCBI Sequence Viewer  
  AAC62640 (Get FASTA)   NCBI Sequence Viewer  
  AAC62641 (Get FASTA)   NCBI Sequence Viewer  
  AAC62642 (Get FASTA)   NCBI Sequence Viewer  
  AAC62643 (Get FASTA)   NCBI Sequence Viewer  
  AAC62644 (Get FASTA)   NCBI Sequence Viewer  
  AAH90649 (Get FASTA)   NCBI Sequence Viewer  
  AAH92537 (Get FASTA)   NCBI Sequence Viewer  
  AAP87982 (Get FASTA)   NCBI Sequence Viewer  
  AAP87983 (Get FASTA)   NCBI Sequence Viewer  
  AAP87984 (Get FASTA)   NCBI Sequence Viewer  
  AAP87985 (Get FASTA)   NCBI Sequence Viewer  
  AAP87986 (Get FASTA)   NCBI Sequence Viewer  
  AAP87987 (Get FASTA)   NCBI Sequence Viewer  
  BAA32432 (Get FASTA)   NCBI Sequence Viewer  
  BAC33397 (Get FASTA)   NCBI Sequence Viewer  
  BAE23286 (Get FASTA)   NCBI Sequence Viewer  
  EDK97682 (Get FASTA)   NCBI Sequence Viewer  
  EDK97683 (Get FASTA)   NCBI Sequence Viewer  
  EDK97684 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000038117
  ENSMUSP00000038117.7
  ENSMUSP00000067005
  ENSMUSP00000067005.6
  ENSMUSP00000110960
  ENSMUSP00000110961
  ENSMUSP00000110963
  ENSMUSP00000110963.3
  ENSMUSP00000110965
  ENSMUSP00000110965.3
GenBank Protein O88898 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_035771   ⟸   NM_011641
- Peptide Label: isoform d
- UniProtKB: Q5CZX0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001120731   ⟸   NM_001127259
- Peptide Label: isoform a
- UniProtKB: Q9QWY9 (UniProtKB/Swiss-Prot),   Q8C826 (UniProtKB/Swiss-Prot),   O89097 (UniProtKB/Swiss-Prot),   O88899 (UniProtKB/Swiss-Prot),   O88897 (UniProtKB/Swiss-Prot),   Q9QWZ0 (UniProtKB/Swiss-Prot),   O88898 (UniProtKB/Swiss-Prot),   Q5CZX0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001120732   ⟸   NM_001127260
- Peptide Label: isoform b
- UniProtKB: O88898 (UniProtKB/Swiss-Prot),   Q5CZX0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001120733   ⟸   NM_001127261
- Peptide Label: isoform c
- UniProtKB: O88898 (UniProtKB/Swiss-Prot),   Q569E5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001120734   ⟸   NM_001127262
- Peptide Label: isoform f
- UniProtKB: O88898 (UniProtKB/Swiss-Prot),   Q5CZX0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001120736   ⟸   NM_001127264
- Peptide Label: isoform e
- UniProtKB: Q3UVI3 (UniProtKB/TrEMBL),   Q5CZX0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001120735   ⟸   NM_001127263
- Peptide Label: isoform g
- UniProtKB: Q569E5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001120737   ⟸   NM_001127265
- Peptide Label: isoform h
- UniProtKB: O88898 (UniProtKB/Swiss-Prot),   Q569E5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006522065   ⟸   XM_006522002
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006522064   ⟸   XM_006522001
- Peptide Label: isoform X2
- UniProtKB: Q5CZX0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000067005   ⟸   ENSMUST00000065523
Ensembl Acc Id: ENSMUSP00000038117   ⟸   ENSMUST00000040231
Ensembl Acc Id: ENSMUSP00000110959   ⟸   ENSMUST00000115304
Ensembl Acc Id: ENSMUSP00000110962   ⟸   ENSMUST00000115307
Ensembl Acc Id: ENSMUSP00000110963   ⟸   ENSMUST00000115308
Ensembl Acc Id: ENSMUSP00000110960   ⟸   ENSMUST00000115305
Ensembl Acc Id: ENSMUSP00000110961   ⟸   ENSMUST00000115306
Ensembl Acc Id: ENSMUSP00000110965   ⟸   ENSMUST00000115310
RefSeq Acc Id: NP_001413966   ⟸   NM_001427037
- Peptide Label: isoform i
- UniProtKB: Q5CZX0 (UniProtKB/TrEMBL)
Protein Domains
p53 DNA-binding   p53 tetramerisation   SAM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88898-F1-model_v2 AlphaFold O88898 1-680 view protein structure

Promoters
RGD ID:8685876
Promoter ID:EPDNEW_M20969
Type:single initiation site
Name:Trp63_3
Description:Mus musculus transformation related protein 63 , transcript variant8, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M20970  EPDNEW_M20971  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381625,683,763 - 25,683,823EPDNEW
RGD ID:8685878
Promoter ID:EPDNEW_M20970
Type:multiple initiation site
Name:Trp63_1
Description:Mus musculus transformation related protein 63 , transcript variant8, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M20969  EPDNEW_M20971  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381625,801,916 - 25,801,976EPDNEW
RGD ID:8685880
Promoter ID:EPDNEW_M20971
Type:single initiation site
Name:Trp63_2
Description:Mus musculus transformation related protein 63 , transcript variant8, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M20969  EPDNEW_M20970  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381625,865,701 - 25,865,761EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1330810 AgrOrtholog
Ensembl Genes ENSMUSG00000022510 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000040231 ENTREZGENE
  ENSMUST00000040231.13 UniProtKB/Swiss-Prot
  ENSMUST00000065523 ENTREZGENE
  ENSMUST00000065523.12 UniProtKB/Swiss-Prot
  ENSMUST00000115305 ENTREZGENE
  ENSMUST00000115306 ENTREZGENE
  ENSMUST00000115308 ENTREZGENE
  ENSMUST00000115308.9 UniProtKB/Swiss-Prot
  ENSMUST00000115310 ENTREZGENE
  ENSMUST00000115310.9 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.150.50 UniProtKB/Swiss-Prot
  2.60.40.720 UniProtKB/Swiss-Prot
  4.10.170.10 UniProtKB/Swiss-Prot
InterPro p53-like_TF_DNA-bd UniProtKB/Swiss-Prot
  p53/RUNT-type_TF_DNA-bd_sf UniProtKB/Swiss-Prot
  p53_DNA-bd UniProtKB/Swiss-Prot
  p53_tetramer_sf UniProtKB/Swiss-Prot
  p53_tetrameristn UniProtKB/Swiss-Prot
  p53_tumour_suppressor UniProtKB/Swiss-Prot
  SAM UniProtKB/Swiss-Prot
  SAM/pointed_sf UniProtKB/Swiss-Prot
  Tumor-p63_SAM UniProtKB/Swiss-Prot
KEGG Report mmu:22061 UniProtKB/Swiss-Prot
MGD MGI:1330810 ENTREZGENE
NCBI Gene 22061 ENTREZGENE
PANTHER PTHR11447 UniProtKB/Swiss-Prot
  PTHR11447:SF8 UniProtKB/Swiss-Prot
Pfam P53 UniProtKB/Swiss-Prot
  P53_tetramer UniProtKB/Swiss-Prot
  SAM_2 UniProtKB/Swiss-Prot
PhenoGen Trp63 PhenoGen
PRINTS P53SUPPRESSR UniProtKB/Swiss-Prot
PROSITE P53 UniProtKB/Swiss-Prot
SMART SAM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47719 UniProtKB/Swiss-Prot
  SSF47769 UniProtKB/Swiss-Prot
  SSF49417 UniProtKB/Swiss-Prot
UniProt A0A0R4J1K8_MOUSE UniProtKB/TrEMBL
  D3Z7K2_MOUSE UniProtKB/TrEMBL
  O88897 ENTREZGENE
  O88898 ENTREZGENE
  O88899 ENTREZGENE
  O89097 ENTREZGENE
  P63_MOUSE UniProtKB/Swiss-Prot
  Q3UVI3 ENTREZGENE, UniProtKB/TrEMBL
  Q569E5 ENTREZGENE, UniProtKB/TrEMBL
  Q5CZX0 ENTREZGENE, UniProtKB/TrEMBL
  Q8C826 ENTREZGENE
  Q9QWY9 ENTREZGENE
  Q9QWZ0 ENTREZGENE
UniProt Secondary O88897 UniProtKB/Swiss-Prot
  O88899 UniProtKB/Swiss-Prot
  O89097 UniProtKB/Swiss-Prot
  Q8C826 UniProtKB/Swiss-Prot
  Q9QWY9 UniProtKB/Swiss-Prot
  Q9QWZ0 UniProtKB/Swiss-Prot