Mecp2 (methyl CpG binding protein 2) - Rat Genome Database

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Gene: Mecp2 (methyl CpG binding protein 2) Mus musculus
Analyze
Symbol: Mecp2
Name: methyl CpG binding protein 2
RGD ID: 736671
MGI Page MGI
Description: Enables several functions, including nucleic acid binding activity; promoter-specific chromatin binding activity; and transcription corepressor activity. Involved in several processes, including negative regulation of smooth muscle cell differentiation; negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation; and positive regulation of histone H3-K9 trimethylation. Acts upstream of or within several processes, including learning or memory; nervous system development; and regulation of gene expression. Located in cytosol and nucleus. Part of heterochromatin. Is expressed in several structures, including alimentary system; early conceptus; nervous system; paraxial mesenchyme; and sensory organ. Used to study Rett syndrome. Human ortholog(s) of this gene implicated in Rett syndrome; autistic disorder; gastrointestinal system disease; severe congenital encephalopathy due to MECP2 mutation; and syndromic X-linked intellectual disability (multiple). Orthologous to human MECP2 (methyl-CpG binding protein 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1500041B07Rik; BB130002; D630021H01Rik; Mbd5; meCp-2 protein; methyl-CpG-binding protein 2; WBP1; WBP10
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X73,070,198 - 73,129,296 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX73,070,198 - 73,178,969 (-)EnsemblGRCm39 Ensembl
GRCm38X74,026,592 - 74,085,690 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX74,026,592 - 74,135,363 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X71,272,160 - 71,330,975 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X70,279,550 - 70,338,313 (-)NCBIMGSCv36mm8
CeleraX65,279,211 - 65,338,021 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.63NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adrenoleukodystrophy  (ISO)
Angelman syndrome  (ISO)
Animal Disease Models  (ISO)
anxiety disorder  (ISO)
attention deficit hyperactivity disorder  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
Barth syndrome  (ISO)
bruxism  (ISO)
Cocaine-Related Disorders  (ISO)
Craniofacial Abnormalities  (ISO)
creatine transporter deficiency  (ISO)
Developmental Disabilities  (ISO)
Developmental Disease  (ISO)
dyskeratosis congenita  (ISO)
Emery-Dreifuss muscular dystrophy  (ISO)
epilepsy  (ISO)
Facial Hypertrichosis  (ISO)
favism  (ISO)
Fetal Growth Retardation  (ISO)
focal epilepsy  (ISO)
frontometaphyseal dysplasia  (ISO)
gastrointestinal system disease  (ISO)
Generalized Epilepsy  (ISO)
genetic disease  (ISO)
Hearing Loss  (ISO)
hepatocellular carcinoma  (ISO)
Hyperalgesia  (ISO)
immunodeficiency 33  (ISO)
intellectual disability  (ISO)
Juberg Hayward Syndrome  (ISO)
learning disability  (ISO)
Melnick-Needles syndrome  (ISO)
methylmalonic acidemia and homocysteinemia cblX type  (ISO)
microcephaly  (ISO)
Micrognathism  (ISO)
Muscle Hypotonia  (ISO)
Myoclonus  (ISO)
Nervous System Malformations  (ISO)
Neurodevelopmental Disorders  (ISO)
non-syndromic X-linked intellectual disability  (ISO)
otopalatodigital syndrome type 2  (ISO)
paraplegia  (ISO)
periventricular nodular heterotopia  (ISO)
Periventricular Nodular Heterotopia 4  (ISO)
pervasive developmental disorder  (ISO)
Psychomotor Disorders  (ISO)
pulmonary fibrosis  (ISO)
respiratory failure  (ISO)
Rett syndrome  (IAGP,IMP,ISO)
Rett Syndrome, Atypical  (ISO)
Rett Syndrome, Zappella Variant  (ISO)
schizophrenia  (ISO)
severe congenital encephalopathy due to MECP2 mutation  (ISO)
Smith-Magenis syndrome  (ISO)
Splenomegaly  (ISO)
stereotypic movement disorder  (ISO)
syndromic X-linked intellectual disability Lubs type  (ISO)
transient cerebral ischemia  (ISO)
visual epilepsy  (ISO)
X-Linked Intellectual Developmental Disorders  (ISO)
X-linked intellectual disability-psychosis-macroorchidism syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bicuculline  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
butanal  (ISO)
C60 fullerene  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
cocaine  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
curcumin  (ISO)
diarsenic trioxide  (ISO)
dichlorine  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
flavonoids  (ISO)
fluoxetine  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
gentamycin  (EXP)
guggulsterone  (ISO)
homocysteine  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
melittin  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
mitomycin C  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
permethrin  (ISO)
phenobarbital  (ISO)
potassium chloride  (EXP)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
succimer  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
tungsten  (EXP)
valproic acid  (EXP,ISO)
withaferin A  (ISO)
zebularine  (ISO)
zolpidem  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (IMP)
associative learning  (IMP)
behavioral fear response  (IMP)
biogenic amine metabolic process  (IMP)
brain development  (IMP)
cardiolipin metabolic process  (IMP)
catecholamine secretion  (IMP)
cell population proliferation  (IMP)
cellular response to isoquinoline alkaloid  (ISO)
cellular response to potassium ion  (ISO)
cerebellum development  (IMP,ISO)
cerebral cortex development  (ISO)
chemical synaptic transmission  (IMP)
dendrite development  (IMP)
epigenetic regulation of gene expression  (IMP)
excitatory postsynaptic potential  (IMP)
gene expression  (IDA,IMP)
glial cell proliferation  (IMP)
glucocorticoid metabolic process  (IMP)
glutamine metabolic process  (IMP)
heart development  (ISO)
heterochromatin formation  (IMP)
hippocampus development  (ISO)
histone acetylation  (IMP)
histone methylation  (IMP)
inositol metabolic process  (IMP)
learning  (IMP)
long-term memory  (IMP)
long-term synaptic potentiation  (IMP)
lung alveolus development  (ISO)
memory  (IMP)
mitotic spindle organization  (ISO)
multicellular organismal response to stress  (IMP)
negative regulation of angiogenesis  (ISO)
negative regulation of astrocyte differentiation  (ISO)
negative regulation of blood vessel endothelial cell migration  (ISO)
negative regulation of dendrite extension  (ISO)
negative regulation of dendritic spine development  (ISO)
negative regulation of DNA-templated transcription  (IDA,IMP,ISO)
negative regulation of gene expression  (ISO)
negative regulation of locomotion involved in locomotory behavior  (ISO)
negative regulation of neuron apoptotic process  (IMP)
negative regulation of primary miRNA processing  (ISO)
negative regulation of protein binding  (ISO)
negative regulation of respiratory gaseous exchange  (ISO)
negative regulation of smooth muscle cell differentiation  (IMP)
negative regulation of transcription by RNA polymerase II  (IBA,IDA,IMP,ISO)
negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation  (IDA)
nervous system process involved in regulation of systemic arterial blood pressure  (IMP)
neuromuscular process  (IMP)
neuromuscular process controlling posture  (IMP)
neuron differentiation  (IDA,IMP,ISO)
neuron maturation  (IMP)
neuron projection development  (IMP)
Notch signaling pathway  (IDA)
olfactory bulb development  (ISO)
oligodendrocyte development  (ISO)
oligodendrocyte differentiation  (ISO)
phosphatidylcholine metabolic process  (IMP)
positive regulation of anterograde dense core granule transport  (ISO)
positive regulation of branching morphogenesis of a nerve  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of dendrite extension  (ISO)
positive regulation of dendritic spine development  (ISO)
positive regulation of DNA methylation  (ISO)
positive regulation of DNA-templated transcription  (IDA)
positive regulation of G2/M transition of mitotic cell cycle  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glial cell proliferation  (IMP)
positive regulation of histone H3-K9 trimethylation  (IDA)
positive regulation of microtubule nucleation  (ISO)
positive regulation of retrograde dense core granule transport  (ISO)
positive regulation of synaptic plasticity  (ISO)
positive regulation of transcription by RNA polymerase II  (IMP)
post-embryonic development  (IMP)
principal sensory nucleus of trigeminal nerve development  (ISO)
proprioception  (IMP)
protein localization  (IMP)
regulation of action potential firing threshold  (ISO)
regulation of DNA methylation  (ISO)
regulation of gene expression  (IDA)
regulation of gene expression by genomic imprinting  (IMP,ISO)
regulation of histone H3-K9 methylation  (IMP)
regulation of respiratory gaseous exchange by nervous system process  (IMP)
regulation of synapse organization  (ISO)
regulation of synaptic plasticity  (IMP)
regulation of transcription by RNA polymerase II  (IMP)
respiratory gaseous exchange by respiratory system  (IMP)
response to cocaine  (ISO)
response to estradiol  (ISO)
response to hypoxia  (IMP)
response to ionizing radiation  (ISO)
response to lead ion  (ISO)
response to organic cyclic compound  (ISO)
response to other organism  (IMP)
sensory perception of pain  (IMP)
social behavior  (IMP,ISO)
spinal cord development  (ISO)
startle response  (IMP)
striatum development  (ISO)
synapse assembly  (IMP)
thalamus development  (ISO)
trans-synaptic signaling by BDNF  (IMP)
triglyceride metabolic process  (IMP)
ventricular system development  (IMP)
visual learning  (IMP)

Cellular Component
centrosome  (ISO)
chromatin  (ISO)
cytoplasm  (IDA)
cytosol  (IDA)
glutamatergic synapse  (ISO)
heterochromatin  (IBA,IDA,ISO)
nucleoplasm  (ISO,TAS)
nucleus  (IBA,IDA,ISO)
protein-containing complex  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal action potential  (IAGP)
abnormal associative learning  (IAGP)
abnormal behavior  (IAGP)
abnormal body temperature  (IAGP)
abnormal body weight  (IAGP)
abnormal brain development  (IAGP)
abnormal brain wave pattern  (IAGP)
abnormal breathing pattern  (IAGP)
abnormal cell nucleus morphology  (IAGP)
abnormal cerebellar granule layer morphology  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal contextual conditioning behavior  (IAGP)
abnormal cued conditioning behavior  (IAGP)
abnormal dendrite morphology  (IAGP)
abnormal dentate gyrus morphology  (IAGP)
abnormal dosage compensation, by inactivation of X chromosome  (IAGP)
abnormal excitatory postsynaptic currents  (IAGP)
abnormal excitatory postsynaptic potential  (IAGP)
abnormal fear/anxiety-related behavior  (IAGP)
abnormal gait  (IAGP)
abnormal hearing physiology  (IAGP)
abnormal heart rate  (IAGP)
abnormal heartbeat  (IAGP)
abnormal hippocampus CA2 region morphology  (IAGP)
abnormal hippocampus morphology  (IAGP)
abnormal hippocampus neuron morphology  (IAGP)
abnormal hippocampus physiology  (IAGP)
abnormal hippocampus pyramidal cell morphology  (IAGP)
abnormal jaw morphology  (IAGP)
abnormal locomotor activation  (IAGP)
abnormal locomotor behavior  (IAGP)
abnormal locomotor coordination  (IAGP)
abnormal long term object recognition memory  (IAGP)
abnormal miniature excitatory postsynaptic currents  (IAGP)
abnormal miniature inhibitory postsynaptic currents  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal motor coordination/balance  (IAGP)
abnormal motor learning  (IAGP)
abnormal nervous system electrophysiology  (IAGP)
abnormal nervous system physiology  (IAGP)
abnormal nest building behavior  (IAGP)
abnormal neuron morphology  (IAGP)
abnormal neuron physiology  (IAGP)
abnormal olfactory bulb morphology  (IAGP)
abnormal orbitofrontal cortex morphology  (IAGP)
abnormal parasympathetic nervous system physiology  (IAGP)
abnormal pilomotor reflex  (IAGP)
abnormal placenta morphology  (IAGP)
abnormal respiration  (IAGP)
abnormal respiratory function  (IAGP)
abnormal response to novel object  (IAGP)
abnormal response to novelty  (IAGP)
abnormal social investigation  (IAGP)
abnormal spatial learning  (IAGP)
abnormal spatial working memory  (IAGP)
abnormal sympathetic nervous system physiology  (IAGP)
abnormal synaptic neurotransmitter level  (IAGP)
abnormal synaptic vesicle number  (IAGP)
abnormal tooth morphology  (IAGP)
abnormal touch/ nociception  (IAGP)
abnormal vibrissa morphology  (IAGP)
akinesia  (IAGP)
apnea  (IAGP)
ataxia  (IAGP)
atrioventricular block  (IAGP)
cachexia  (IAGP)
cryptorchism  (IAGP)
decreased anxiety-related response  (IAGP)
decreased body temperature  (IAGP)
decreased body weight  (IAGP)
decreased brain size  (IAGP)
decreased brain weight  (IAGP)
decreased CNS synapse formation  (IAGP)
decreased grip strength  (IAGP)
decreased heart rate  (IAGP)
decreased locomotor activity  (IAGP)
decreased neuron number  (IAGP)
decreased noradrenaline level  (IAGP)
decreased prepulse inhibition  (IAGP)
decreased serotonin level  (IAGP)
decreased startle reflex  (IAGP)
decreased thigmotaxis  (IAGP)
decreased tidal volume  (IAGP)
decreased vertical activity  (IAGP)
dermatitis  (IAGP)
disheveled coat  (IAGP)
environmentally induced seizures  (IAGP)
extended life span  (IAGP)
eye inflammation  (IAGP)
female infertility  (IEA)
focal hair loss  (IAGP)
greasy coat  (IAGP)
hyperactivity  (IAGP)
impaired contextual conditioning behavior  (IAGP)
impaired coordination  (IAGP)
impaired cued conditioning behavior  (IAGP)
increased anxiety-related response  (IAGP)
increased body weight  (IAGP)
increased brain cholesterol level  (IAGP)
increased brain weight  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating LDL cholesterol level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased fear-related response  (IAGP)
increased grooming behavior  (IAGP)
increased heart rate variability  (IAGP)
increased heart weight  (IAGP)
increased liver triglyceride level  (IAGP)
increased liver weight  (IAGP)
increased muscle fatigability  (IAGP)
increased placenta apoptosis  (IAGP)
increased prepulse inhibition  (IAGP)
increased pulmonary respiratory rate  (IAGP)
increased response of heart to induced stress  (IAGP)
increased stereotypic behavior  (IAGP)
increased susceptibility to age related obesity  (IAGP)
increased susceptibility to pharmacologically induced seizures  (IAGP)
increased thermal nociceptive threshold  (IAGP)
increased total fat pad weight  (IAGP)
increased vertical activity  (IAGP)
irregular heartbeat  (IAGP)
kyphosis  (IAGP)
lethargy  (IAGP)
limb grasping  (IAGP)
male infertility  (IAGP)
malocclusion  (IAGP)
no abnormal phenotype detected  (IEA)
obese  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
prolonged QT interval  (IAGP)
reduced long term potentiation  (IAGP)
respiratory distress  (IAGP)
ruffled hair  (IAGP)
seizures  (IAGP)
short stride length  (IAGP)
skin lesions  (IAGP)
slow postnatal weight gain  (IAGP)
sporadic seizures  (IAGP)
stereotypic behavior  (IAGP)
tachypnea  (IAGP)
tonic-clonic seizures  (IAGP)
tremors  (IAGP)
ventricular premature beat  (IAGP)
ventricular tachycardia  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Gross rearrangements of the MECP2 gene are found in both classical and atypical Rett syndrome patients. Archer HL, etal., J Med Genet. 2006 May;43(5):451-6. Epub 2005 Sep 23.
2. A detailed analysis of the MECP2 gene: prevalence of recurrent mutations and gross DNA rearrangements in Rett syndrome patients. Bourdon V, etal., Hum Genet. 2001 Jan;108(1):43-50.
3. On how mammalian transcription factors recognize methylated DNA. Buck-Koehntop BA and Defossez PA, Epigenetics. 2013 Feb;8(2):131-7. doi: 10.4161/epi.23632. Epub 2013 Jan 16.
4. MECP2 is highly mutated in X-linked mental retardation. Couvert P, etal., Hum Mol Genet. 2001 Apr 15;10(9):941-6.
5. A complex pattern of evolutionary conservation and alternative polyadenylation within the long 3"-untranslated region of the methyl-CpG-binding protein 2 gene (MeCP2) suggests a regulatory role in gene expression. Coy JF, etal., Hum Mol Genet 1999 Jul;8(7):1253-62.
6. A comparison of molecular alterations in environmental and genetic rat models of ADHD: a pilot study. DasBanerjee T, etal., Am J Med Genet B Neuropsychiatr Genet. 2008 Dec 5;147B(8):1554-63.
7. Kindling induces the mRNA expression of methyl DNA-binding factors in the adult rat hippocampus. Francis J, etal., Neuroscience. 2002;113(1):79-87.
8. A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Guy J, etal., Nat Genet. 2001 Mar;27(3):322-6.
9. MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212. Im HI, etal., Nat Neurosci. 2010 Sep;13(9):1120-7. doi: 10.1038/nn.2615. Epub 2010 Aug 15.
10. RNAi-induced down-regulation of Mecp2 expression in the rat brain. Jin J, etal., Int J Dev Neurosci. 2008 Aug;26(5):457-65. doi: 10.1016/j.ijdevneu.2008.02.009. Epub 2008 Mar 4.
11. Transient forebrain ischemia alters the mRNA expression of methyl DNA-binding factors in the adult rat hippocampus. Jung BP, etal., Neuroscience. 2002;115(2):515-24.
12. Uteroplacental insufficiency affects epigenetic determinants of chromatin structure in brains of neonatal and juvenile IUGR rats. Ke X, etal., Physiol Genomics. 2006 Mar 13;25(1):16-28. Epub 2005 Dec 27.
13. Role of de novo DNA methyltransferases and methyl CpG-binding proteins in gene silencing in a rat hepatoma. Majumder S, etal., J Biol Chem. 2002 May 3;277(18):16048-58. Epub 2002 Feb 13.
14. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
15. MGDs mouse GO annotations MGD data from the GO Consortium
16. MGD IEA MGD IEA
17. Gastrointestinal and nutritional problems occur frequently throughout life in girls and women with Rett syndrome. Motil KJ, etal., J Pediatr Gastroenterol Nutr. 2012 Sep;55(3):292-8. doi: 10.1097/MPG.0b013e31824b6159.
18. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. MeCP2 deficiency results in robust Rett-like behavioural and motor deficits in male and female rats. Patterson KC, etal., Hum Mol Genet. 2016 Dec 15;25(24):5514-5515. doi: 10.1093/hmg/ddw435.
21. Mouse MP Annotation Import Pipeline RGD automated import pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. MECP2 structural and 3'-UTR variants in schizophrenia, autism and other psychiatric diseases: a possible association with autism. Shibayama A, etal., Am J Med Genet B Neuropsychiatr Genet. 2004 Jul 1;128B(1):50-3.
25. Characterization of Rett Syndrome-like phenotypes in Mecp2-knockout rats. Wu Y, etal., J Neurodev Disord. 2016 Jun 16;8:23. doi: 10.1186/s11689-016-9156-7. eCollection 2016.
Additional References at PubMed
PMID:1631115   PMID:2180582   PMID:8001979   PMID:8563762   PMID:8589515   PMID:8769643   PMID:8889548   PMID:9160753   PMID:9171351   PMID:9774669   PMID:10349636   PMID:10723722  
PMID:10888872   PMID:11042159   PMID:11058114   PMID:11076861   PMID:11160912   PMID:11217851   PMID:11242118   PMID:11371345   PMID:11441023   PMID:11748221   PMID:11809720   PMID:12160743  
PMID:12427740   PMID:12432090   PMID:12442230   PMID:12477932   PMID:12727440   PMID:12904583   PMID:12928486   PMID:14519686   PMID:14593183   PMID:14593184   PMID:14610273   PMID:14643676  
PMID:14681479   PMID:14973779   PMID:15034150   PMID:15069197   PMID:15115765   PMID:15342650   PMID:15345242   PMID:15351775   PMID:15489334   PMID:15492925   PMID:15519245   PMID:15548546  
PMID:15608638   PMID:15696166   PMID:15733677   PMID:15757975   PMID:15780747   PMID:15809268   PMID:15837557   PMID:15888476   PMID:15917271   PMID:15939091   PMID:15939760   PMID:15975715  
PMID:15977646   PMID:16087343   PMID:16116096   PMID:16141072   PMID:16141073   PMID:16199017   PMID:16251199   PMID:16251272   PMID:16354910   PMID:16380085   PMID:16399702   PMID:16439027  
PMID:16446138   PMID:16467389   PMID:16543822   PMID:16549272   PMID:16549521   PMID:16581518   PMID:16602821   PMID:16613900   PMID:16680199   PMID:16682435   PMID:16754645   PMID:16782889  
PMID:16848781   PMID:17046689   PMID:17050729   PMID:17108082   PMID:17114649   PMID:17204503   PMID:17237885   PMID:17267601   PMID:17278996   PMID:17289941   PMID:17296936   PMID:17309881  
PMID:17383101   PMID:17395475   PMID:17464364   PMID:17532643   PMID:17544925   PMID:17546630   PMID:17584923   PMID:17635839   PMID:17701895   PMID:17913925   PMID:17920015   PMID:17936729  
PMID:17965622   PMID:17994015   PMID:17997046   PMID:18006868   PMID:18032561   PMID:18058824   PMID:18159237   PMID:18203756   PMID:18223199   PMID:18287934   PMID:18295506   PMID:18306326  
PMID:18321864   PMID:18321865   PMID:18329113   PMID:18334558   PMID:18425126   PMID:18511691   PMID:18534925   PMID:18557922   PMID:18571096   PMID:18687363   PMID:18690105   PMID:18701457  
PMID:18761004   PMID:18778693   PMID:18799693   PMID:18817733   PMID:18834926   PMID:18989361   PMID:19000991   PMID:19012748   PMID:19109157   PMID:19138667   PMID:19167498   PMID:19177165  
PMID:19208815   PMID:19225110   PMID:19234456   PMID:19296534   PMID:19331822   PMID:19339616   PMID:19359374   PMID:19369296   PMID:19386901   PMID:19414073   PMID:19427855   PMID:19521566  
PMID:19524074   PMID:19561615   PMID:19571810   PMID:19602036   PMID:19620975   PMID:19628041   PMID:19674087   PMID:19710912   PMID:19741133   PMID:19793977   PMID:19812320   PMID:19820693  
PMID:19843474   PMID:19898468   PMID:19900619   PMID:19906978   PMID:19932741   PMID:19958389   PMID:19966177   PMID:19998492   PMID:20007372   PMID:20010955   PMID:20025874   PMID:20040383  
PMID:20042730   PMID:20045053   PMID:20093853   PMID:20107077   PMID:20138994   PMID:20159591   PMID:20163734   PMID:20172507   PMID:20188178   PMID:20188665   PMID:20193660   PMID:20200124  
PMID:20203171   PMID:20211142   PMID:20298210   PMID:20368621   PMID:20381590   PMID:20385708   PMID:20392952   PMID:20392956   PMID:20504995   PMID:20599664   PMID:20625242   PMID:20625482  
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PMID:21068835   PMID:21085180   PMID:21120444   PMID:21212100   PMID:21232545   PMID:21239731   PMID:21267068   PMID:21296130   PMID:21307327   PMID:21307341   PMID:21330301   PMID:21350014  
PMID:21394759   PMID:21420494   PMID:21435439   PMID:21471155   PMID:21471397   PMID:21482354   PMID:21497756   PMID:21511710   PMID:21609470   PMID:21636743   PMID:21677750   PMID:21716289  
PMID:21753013   PMID:21765426   PMID:21791604   PMID:21829232   PMID:21831886   PMID:21873635   PMID:21880923   PMID:21901842   PMID:21909962   PMID:21982370   PMID:22009741   PMID:22037496  
PMID:22042248   PMID:22119903   PMID:22127389   PMID:22138506   PMID:22174313   PMID:22186023   PMID:22230884   PMID:22231481   PMID:22249109   PMID:22252744   PMID:22262897   PMID:22297041  
PMID:22302819   PMID:22334035   PMID:22343140   PMID:22355564   PMID:22357867   PMID:22374971   PMID:22375006   PMID:22378884   PMID:22395464   PMID:22412847   PMID:22425995   PMID:22500635  
PMID:22615490   PMID:22653753   PMID:22677942   PMID:22709555   PMID:22815516   PMID:22822052   PMID:22865604   PMID:22891354   PMID:22919518   PMID:22923521   PMID:22973007   PMID:23010509  
PMID:23011033   PMID:23015442   PMID:23022455   PMID:23026749   PMID:23027959   PMID:23035095   PMID:23055506   PMID:23077217   PMID:23112857   PMID:23180809   PMID:23185431   PMID:23197715  
PMID:23227269   PMID:23238573   PMID:23246925   PMID:23259945   PMID:23260135   PMID:23335972   PMID:23362347   PMID:23392116   PMID:23448145   PMID:23452848   PMID:23462290   PMID:23558747  
PMID:23643691   PMID:23659895   PMID:23684790   PMID:23705018   PMID:23750231   PMID:23751821   PMID:23754746   PMID:23770565   PMID:23770587   PMID:23791832   PMID:23875667   PMID:23892605  
PMID:23948639   PMID:23960241   PMID:23986203   PMID:23992846   PMID:23992847   PMID:24009314   PMID:24039126   PMID:24060648   PMID:24067915   PMID:24078059   PMID:24089468   PMID:24105466  
PMID:24109855   PMID:24151012   PMID:24188180   PMID:24218106   PMID:24270455   PMID:24283265   PMID:24285883   PMID:24351104   PMID:24352790   PMID:24394521   PMID:24472844   PMID:24512669  
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PMID:24667344   PMID:24671997   PMID:24735673   PMID:24750778   PMID:24769161   PMID:24777420   PMID:24803651   PMID:24952961   PMID:24958851   PMID:24958888   PMID:24958891   PMID:24968028  
PMID:24970834   PMID:24978323   PMID:24990380   PMID:24990928   PMID:24996410   PMID:25008110   PMID:25009110   PMID:25088363   PMID:25147297   PMID:25209898   PMID:25209930   PMID:25232122  
PMID:25297674   PMID:25299635   PMID:25392929   PMID:25420914   PMID:25424712   PMID:25445449   PMID:25527496   PMID:25541993   PMID:25620416   PMID:25634563   PMID:25639236   PMID:25662825  
PMID:25673846   PMID:25708779   PMID:25713300   PMID:25722434   PMID:25753729   PMID:25762136   PMID:25769649   PMID:25779967   PMID:25798578   PMID:25870282   PMID:25875630   PMID:25878291  
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PMID:26476268   PMID:26482727   PMID:26499511   PMID:26590342   PMID:26604147   PMID:26605526   PMID:26647311   PMID:26733386   PMID:26772194   PMID:26806603   PMID:26821710   PMID:26821816  
PMID:26842955   PMID:26843422   PMID:26869885   PMID:26883520   PMID:26908602   PMID:26929363   PMID:26936821   PMID:26982160   PMID:27008915   PMID:27015692   PMID:27030715   PMID:27043280  
PMID:27080430   PMID:27097329   PMID:27103432   PMID:27194336   PMID:27254746   PMID:27288453   PMID:27293187   PMID:27317352   PMID:27323888   PMID:27328321   PMID:27328325   PMID:27352031  
PMID:27428650   PMID:27458802   PMID:27499081   PMID:27653984   PMID:27668390   PMID:27670841   PMID:27672368   PMID:27713690   PMID:27782879   PMID:27789278   PMID:27803317   PMID:27828991  
PMID:27881780   PMID:27892851   PMID:27895554   PMID:27916441   PMID:27923996   PMID:27941951   PMID:27965390   PMID:27974239   PMID:28041914   PMID:28093257   PMID:28098153   PMID:28138553  
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PMID:28367114   PMID:28394263   PMID:28423315   PMID:28459435   PMID:28480880   PMID:28498846   PMID:28506623   PMID:28524723   PMID:28604632   PMID:28621434   PMID:28659760   PMID:28679669  
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PMID:30540948   PMID:30550785   PMID:30560934   PMID:30608967   PMID:30619462   PMID:30809933   PMID:30890637   PMID:30923887   PMID:31038696   PMID:31112129   PMID:31114506   PMID:31117273  
PMID:31138832   PMID:31229630   PMID:31239460   PMID:31291284   PMID:31299345   PMID:31333414   PMID:31352003   PMID:31366578   PMID:31398341   PMID:31474834   PMID:31562178   PMID:31597640  
PMID:31601272   PMID:31629059   PMID:31671722   PMID:31758234   PMID:31784358   PMID:31784360   PMID:31868585   PMID:31911459   PMID:31913581   PMID:31974426   PMID:32015323   PMID:32015540  
PMID:32051524   PMID:32063830   PMID:32144612   PMID:32159514   PMID:32200043   PMID:32207685   PMID:32209477   PMID:32286307   PMID:32317254   PMID:32325033   PMID:32332080   PMID:32343226  
PMID:32383329   PMID:32393583   PMID:32420873   PMID:32469049   PMID:32507875   PMID:32526163   PMID:32561780   PMID:32589877   PMID:32616668   PMID:32622786   PMID:32652084   PMID:32668243  
PMID:32749543   PMID:32798727   PMID:32801153   PMID:32927061   PMID:33010341   PMID:33046553   PMID:33048927   PMID:33084871   PMID:33193060   PMID:33203444   PMID:33296675   PMID:33335218  
PMID:33361117   PMID:33373327   PMID:33383186   PMID:33494858   PMID:33551790   PMID:33561390   PMID:33598674   PMID:33658357   PMID:33665914   PMID:33737384   PMID:33762729   PMID:33918872  
PMID:33919253   PMID:34010654   PMID:34021030   PMID:34040112   PMID:34059381   PMID:34183865   PMID:34192606   PMID:34201747   PMID:34228646   PMID:34230964   PMID:34234891   PMID:34281226  
PMID:34282222   PMID:34324427   PMID:34363729   PMID:34502373   PMID:34572143   PMID:34582789   PMID:34599184   PMID:34602980   PMID:34678068   PMID:34690674   PMID:34895132   PMID:34916612  
PMID:34967263   PMID:35008655   PMID:35021077   PMID:35074918   PMID:35091041   PMID:35148843   PMID:35154497   PMID:35242007   PMID:35358499   PMID:35365601   PMID:35620663   PMID:35628543  
PMID:35664078   PMID:35711008   PMID:35794118   PMID:35915222   PMID:36041430   PMID:36060065   PMID:36064580   PMID:36082308   PMID:36200140   PMID:36430502   PMID:36703978   PMID:36835623  
PMID:36848184   PMID:36931532   PMID:36982190  


Genomics

Comparative Map Data
Mecp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X73,070,198 - 73,129,296 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX73,070,198 - 73,178,969 (-)EnsemblGRCm39 Ensembl
GRCm38X74,026,592 - 74,085,690 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX74,026,592 - 74,135,363 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X71,272,160 - 71,330,975 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X70,279,550 - 70,338,313 (-)NCBIMGSCv36mm8
CeleraX65,279,211 - 65,338,021 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.63NCBI
MECP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X154,021,573 - 154,097,717 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX154,021,573 - 154,137,103 (-)EnsemblGRCh38hg38GRCh38
GRCh37X153,287,024 - 153,363,174 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X152,940,458 - 153,016,323 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X152,808,110 - 152,883,976NCBI
CeleraX153,520,969 - 153,596,868 (-)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX141,928,231 - 142,007,659 (-)NCBIHuRef
CHM1_1X153,161,670 - 153,237,718 (-)NCBICHM1_1
T2T-CHM13v2.0X152,295,254 - 152,371,375 (-)NCBIT2T-CHM13v2.0
Mecp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X151,781,177 - 151,844,687 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX151,789,930 - 151,844,689 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX153,931,091 - 153,985,757 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X157,494,308 - 157,548,973 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X155,166,123 - 155,220,783 (-)NCBIRnor_WKY
Rnor_6.0X156,650,389 - 156,713,813 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,655,960 - 156,705,233 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,390,961 - 152,461,647 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,980,599 - 160,035,260 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X160,055,071 - 160,104,134 (-)NCBI
Celera1136,055,782 - 136,105,104 (+)NCBICelera
Cytogenetic MapXq37NCBI
Mecp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955580679,109 - 735,288 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955580674,014 - 737,586 (-)NCBIChiLan1.0ChiLan1.0
MECP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1X154,065,444 - 154,140,771 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X143,571,864 - 143,647,192 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X153,458,248 - 153,527,854 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX153,465,204 - 153,527,854 (-)Ensemblpanpan1.1panPan2
MECP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X121,866,721 - 121,876,088 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX121,873,218 - 121,932,994 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX107,201,895 - 107,204,829 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X125,014,436 - 125,017,609 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X120,783,667 - 120,786,824 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X123,299,346 - 123,302,280 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X123,060,405 - 123,063,561 (-)NCBIUU_Cfam_GSD_1.0
Mecp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X119,165,167 - 119,228,780 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936809911,764 - 966,839 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936809902,938 - 967,771 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MECP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX124,735,656 - 124,738,659 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X124,735,523 - 124,789,063 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X142,295,001 - 142,349,438 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MECP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X128,445,028 - 128,519,892 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX128,453,577 - 128,455,785 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606566,318,831 - 66,395,535 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mecp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624946628,284 - 685,246 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624946620,581 - 685,339 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mecp2
47 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir132mmu-miR-132-3pMirtarbaseexternal_infoImmunoblot//Immunohistochemistry//ImmunoprecipitaiFunctional MTI (Weak)19843474
Mir132mmu-miR-132-3pMirtarbaseexternal_infoImmunoprecipitaion//Luciferase reporter assay//qRTFunctional MTI21118894
Mir212mmu-miR-212-3pOncomiRDBexternal_infoNANA20020497

Predicted Target Of
Summary Value
Count of predictions:7876
Count of miRNA genes:982
Interacting mature miRNAs:1460
Transcripts:ENSMUST00000033770, ENSMUST00000100750, ENSMUST00000123362, ENSMUST00000140399, ENSMUST00000170481
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
13208567Bmiq12_mbody mass index QTL 12 (mouse)X3526365377043606Mouse
1301009Pbwg7_mpostnatal body weight growth 7 (mouse)Not determinedX3911371473113814Mouse
4141565Pbwg21_mpostnatal body weight growth 21 (mouse)Not determinedX3911371473113814Mouse
1300794Spha2_msperm head anomaly 2 (mouse)Not determinedX3992149886260137Mouse
4142200Rtwq1_mreduced testis weight QTL 1 (mouse)Not determined4147706075477203Mouse
1301278Bdln1_mbody length 1 (mouse)Not determinedX4170210675702218Mouse
1300702Fcsa4_mfemoral cross-sectional area 4 (mouse)Not determinedX4602744480027567Mouse
4141630Gct6_mgranulosa cell tumorigenesis 6 (mouse)Not determined47179121129764756Mouse
25314311Syncl3_msynaptonemal complex length 3 (mouse)X5198887789743606Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X54045360148782996Mouse
10412108Desp5_mdespair 5 (mouse)Not determinedX5472235188722351Mouse
13464140Hdlq108_mHDL QTL 108 (mouse)X5777196091771960Mouse
25314316Mlh1fc3_mMLH1 foci count 3 (mouse)X6134360689843606Mouse
25314318Sccor2_msynaptonemal complex length to mean MLH1 count ratio 2 (mouse)X7054360696543606Mouse
1357730Hstx1_mhybrid sterility, X chromosome 1 (mouse)Not determinedX7145385277600812Mouse
4141665Mhysq2_mmale hybrid sterility QTL 2 (mouse)Not determined71453852139203212Mouse
12879918Shm4_msperm head morphology 4 (mouse)X72072050102062720Mouse

Markers in Region
Mecp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X74,034,266 - 74,035,785UniSTSGRCm38
MGSCv37X71,279,605 - 71,281,124UniSTSGRCm37
CeleraX65,286,657 - 65,288,176UniSTS
Cytogenetic MapXA7.3UniSTS
cM MapX29.6UniSTS
BB130002  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X74,026,656 - 74,026,747UniSTSGRCm38
MGSCv37X71,271,995 - 71,272,086UniSTSGRCm37
CeleraX65,279,046 - 65,279,137UniSTS
Cytogenetic MapXA7.3UniSTS
Whitehead/MRC_RHX864.29UniSTS
UniSTS:238043  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X74,027,749 - 74,027,964UniSTSGRCm38
MGSCv37X71,273,088 - 71,273,303UniSTSGRCm37
CeleraX65,280,139 - 65,280,354UniSTS
Cytogenetic MapXA7.3UniSTS
REN88559  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X74,026,745 - 74,027,000UniSTSGRCm38
MGSCv37X71,272,084 - 71,272,339UniSTSGRCm37
CeleraX65,279,135 - 65,279,390UniSTS
Cytogenetic MapXA7.3UniSTS
REN88597  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X74,035,260 - 74,035,504UniSTSGRCm38
MGSCv37X71,280,599 - 71,280,843UniSTSGRCm37
CeleraX65,287,651 - 65,287,895UniSTS
Cytogenetic MapXA7.3UniSTS
REN88598  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X74,035,447 - 74,035,671UniSTSGRCm38
MGSCv37X71,280,786 - 71,281,010UniSTSGRCm37
CeleraX65,287,838 - 65,288,062UniSTS
Cytogenetic MapXA7.3UniSTS
REN88847  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X74,079,639 - 74,079,880UniSTSGRCm38
MGSCv37X71,324,978 - 71,325,219UniSTSGRCm37
CeleraX65,332,025 - 65,332,266UniSTS
Cytogenetic MapXA7.3UniSTS
ECD14555  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X74,034,771 - 74,035,267UniSTSGRCm38
MGSCv37X71,280,110 - 71,280,606UniSTSGRCm37
CeleraX65,287,162 - 65,287,658UniSTS
Cytogenetic MapXA7.3UniSTS
Mecp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXA7.3UniSTS
Mecp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXA7.3UniSTS
Mecp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXA7.3UniSTS
Mecp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXA7.3UniSTS
Mecp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X74,035,961 - 74,036,268UniSTSGRCm38
MGSCv37X71,281,300 - 71,281,607UniSTSGRCm37
CeleraX65,288,352 - 65,288,659UniSTS
Cytogenetic MapXA7.3UniSTS
cM MapX29.6UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001081979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030251240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA690741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB221662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC091472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF072251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF121351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF158181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK028061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK038715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK041453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK043746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK158664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL672002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC027153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU700810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY107013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000033770   ⟹   ENSMUSP00000033770
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX73,078,894 - 73,129,296 (-)Ensembl
GRCm38.p6 EnsemblX74,035,288 - 74,085,690 (-)Ensembl
RefSeq Acc Id: ENSMUST00000100750   ⟹   ENSMUSP00000098314
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX73,070,198 - 73,129,275 (-)Ensembl
GRCm38.p6 EnsemblX74,026,592 - 74,085,669 (-)Ensembl
RefSeq Acc Id: ENSMUST00000123362   ⟹   ENSMUSP00000118842
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX73,078,895 - 73,129,218 (-)Ensembl
GRCm38.p6 EnsemblX74,035,289 - 74,085,612 (-)Ensembl
RefSeq Acc Id: ENSMUST00000140399   ⟹   ENSMUSP00000119947
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX73,079,276 - 73,129,216 (-)Ensembl
GRCm38.p6 EnsemblX74,035,670 - 74,085,610 (-)Ensembl
RefSeq Acc Id: ENSMUST00000170481   ⟹   ENSMUSP00000127115
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX73,070,434 - 73,178,969 (-)Ensembl
GRCm38.p6 EnsemblX74,026,828 - 74,135,363 (-)Ensembl
RefSeq Acc Id: ENSMUST00000198358
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX73,124,641 - 73,129,203 (-)Ensembl
GRCm38.p6 EnsemblX74,081,035 - 74,085,597 (-)Ensembl
RefSeq Acc Id: NM_001081979   ⟹   NP_001075448
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X73,070,198 - 73,129,296 (-)NCBI
GRCm38X74,026,592 - 74,085,690 (-)NCBI
MGSCv37X71,272,160 - 71,330,975 (-)RGD
CeleraX65,278,982 - 65,338,075 (-)NCBI
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NM_010788   ⟹   NP_034918
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X73,070,198 - 73,129,296 (-)NCBI
GRCm38X74,026,592 - 74,085,690 (-)NCBI
MGSCv37X71,272,160 - 71,330,975 (-)RGD
CeleraX65,278,982 - 65,338,075 (-)NCBI
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030251240   ⟹   XP_030107100
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X73,070,198 - 73,129,246 (-)NCBI
GRCm38X74,026,592 - 74,085,640 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001075448   ⟸   NM_001081979
- Peptide Label: isoform 1
- UniProtKB: Q9Z2D6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_034918   ⟸   NM_010788
- Peptide Label: isoform 2
- UniProtKB: Q3TYG1 (UniProtKB/Swiss-Prot),   Q9Z2D6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030107100   ⟸   XM_030251240
- Peptide Label: isoform X1
- UniProtKB: Q3TYG1 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSMUSP00000127115   ⟸   ENSMUST00000170481
RefSeq Acc Id: ENSMUSP00000033770   ⟸   ENSMUST00000033770
RefSeq Acc Id: ENSMUSP00000119947   ⟸   ENSMUST00000140399
RefSeq Acc Id: ENSMUSP00000098314   ⟸   ENSMUST00000100750
RefSeq Acc Id: ENSMUSP00000118842   ⟸   ENSMUST00000123362
Protein Domains
MBD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z2D6-F1-model_v2 AlphaFold Q9Z2D6 1-484 view protein structure

Promoters
RGD ID:6845950
Promoter ID:MM_KWN:60769
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000042852,   OTTMUST00000043832,   OTTMUST00000049596,   OTTMUST00000086197
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X71,330,586 - 71,331,412 (-)MPROMDB
RGD ID:13680764
Promoter ID:EPDNEW_M24532
Type:initiation region
Name:Mecp2_1
Description:Mus musculus methyl CpG binding protein 2 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X74,085,595 - 74,085,655EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:99918 AgrOrtholog
Ensembl Genes ENSMUSG00000031393 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000033770 ENTREZGENE
  ENSMUSP00000033770.7 UniProtKB/Swiss-Prot
  ENSMUSP00000098314 ENTREZGENE
  ENSMUSP00000098314.4 UniProtKB/Swiss-Prot
  ENSMUSP00000118842.2 UniProtKB/TrEMBL
  ENSMUSP00000119947.2 UniProtKB/TrEMBL
  ENSMUSP00000127115.3 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000033770 ENTREZGENE
  ENSMUST00000033770.13 UniProtKB/Swiss-Prot
  ENSMUST00000100750 ENTREZGENE
  ENSMUST00000100750.10 UniProtKB/Swiss-Prot
  ENSMUST00000123362.8 UniProtKB/TrEMBL
  ENSMUST00000140399.3 UniProtKB/TrEMBL
  ENSMUST00000170481.9 UniProtKB/Swiss-Prot
InterPro DNA-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Me_CpG-bd_MeCP2 UniProtKB/Swiss-Prot
  MeCP2/MBD4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Methyl_CpG_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17257 UniProtKB/Swiss-Prot
MGD MGI:99918 ENTREZGENE
NCBI Gene 17257 ENTREZGENE
PANTHER METHYL-CPG-BINDING PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15074 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mecp2 PhenoGen
PIRSF Methyl_CpG_bd_MeCP2 UniProtKB/Swiss-Prot
PROSITE MBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART MBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54171 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3YY81_MOUSE UniProtKB/TrEMBL
  D3Z7U4_MOUSE UniProtKB/TrEMBL
  MECP2_MOUSE UniProtKB/Swiss-Prot
  Q3TYG1 ENTREZGENE
  Q9Z2D6 ENTREZGENE
UniProt Secondary B1AUZ2 UniProtKB/Swiss-Prot
  B1AUZ3 UniProtKB/Swiss-Prot
  Q3TYG1 UniProtKB/Swiss-Prot