Gene: ARFGEF2 (ADP ribosylation factor guanine nucleotide exchange factor 2) Homo sapiens
Symbol: ARFGEF2
Name: ADP ribosylation factor guanine nucleotide exchange factor 2
Description: ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited); BIG2; brefeldin A-inhibited GEP 2; brefeldin A-inhibited guanine nucleotide-exchange protein 2; dJ1164I10.1; FLJ23723; OTTHUMP00000031231; PVNH2
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382048,921,721 - 49,036,693 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372047,538,250 - 47,653,230 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362046,971,682 - 47,086,637 (+)NCBINCBI36hg18NCBI36
Build 342046,971,833 - 47,083,645NCBI
Celera2044,242,891 - 44,357,843 (+)NCBI
Cytogenetic Map20q13.13NCBI
HuRef2044,289,793 - 44,403,088 (+)NCBIHuRef
CHM1_12047,442,300 - 47,557,463 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ARFGEF2
AGR Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736641
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2017-12-26
Status: ACTIVE