Akr1b1 (aldo-keto reductase family 1 member B) - Rat Genome Database

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Gene: Akr1b1 (aldo-keto reductase family 1 member B) Mus musculus
Analyze
Symbol: Akr1b1
Name: aldo-keto reductase family 1 member B
RGD ID: 736610
MGI Page MGI
Description: Enables L-glucuronate reductase activity and aldose reductase (NADPH) activity. Involved in L-ascorbic acid biosynthetic process and fructose biosynthetic process. Acts upstream of or within several processes, including metanephric collecting duct development; regulation of urine volume; and renal water homeostasis. Is active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in arteriosclerosis; cataract; diabetic neuropathy; diabetic retinopathy; and type 2 diabetes mellitus. Orthologous to human AKR1B1 (aldo-keto reductase family 1 member B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A; Ah; Ahr; Ahr-1; Ahr1; Akr1b3; Al; aldehyde reductase 1; aldo-keto reductase family 1 member B1; aldo-keto reductase family 1 member B3; aldo-keto reductase family 1, member B1 (aldose reductase); Aldor1; aldose reductase; Aldr1; ALR2; AR
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm12015   Gm12138   Gm13983   Gm5395   Gm6122   Gm6644   Gm6736   Gm7678  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39634,280,865 - 34,294,424 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl634,279,369 - 34,294,413 (-)EnsemblGRCm39 Ensembl
GRCm38634,303,930 - 34,317,489 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl634,302,434 - 34,317,478 (-)EnsemblGRCm38mm10GRCm38
MGSCv37634,253,930 - 34,267,489 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36634,234,092 - 34,247,629 (-)NCBIMGSCv36mm8
Celera634,300,847 - 34,314,402 (-)NCBICelera
Cytogenetic Map6B1NCBI
cM Map614.87NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (ISO)
(E)-cinnamyl alcohol  (ISO)
(E,E)-2,4-hexadienal  (ISO)
(R)-acetoin  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
1,2-dimethylhydrazine  (EXP)
1,2-naphthoquinone  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
16-Ketoestrone  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-Nonadienal  (ISO)
2-acetamidofluorene  (EXP)
2-hexenal  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
2-pentenal  (ISO)
3,4-dihydroxybenzoic acid  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-nitrobenzaldehyde  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-2-octenal  (ISO)
4-hydroxyhexenal  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP)
4-nitrobenzaldehyde  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
9,10-phenanthroquinone  (ISO)
acetamide  (ISO)
acetoin  (ISO)
acrolein  (EXP,ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-4-oxoretinal  (ISO)
all-trans-dehydroretinal  (ISO)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
alpha-D-galactose  (EXP)
alpha-hexylcinnamaldehyde  (ISO)
alpha-Zearalanol  (ISO)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimony(0)  (ISO)
antimycin A  (ISO)
apocynin  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
Azoxymethane  (EXP)
azoxystrobin  (ISO)
Bandrowski's base  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzo[a]pyrene-7,8-dione  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (EXP)
benzoic acid  (ISO)
benzyl alcohol  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
butanal  (ISO)
butane-2,3-diol  (ISO)
butane-2,3-dione  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
candesartan  (ISO)
capecitabine  (ISO)
carbon nanotube  (EXP,ISO)
carboplatin  (ISO)
carmustine  (ISO)
cefaloridine  (ISO)
ceruletide  (ISO)
CGP 52608  (ISO)
chlordecone  (EXP)
choline  (EXP)
chromium atom  (ISO)
chromium(6+)  (EXP)
cinnamyl alcohol  (ISO)
cisplatin  (EXP,ISO)
clobetasol  (EXP)
Clofop  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
D-glucitol  (ISO)
D-glucose  (EXP,ISO)
D-glyceraldehyde  (ISO)
daunorubicin  (ISO)
DDE  (ISO)
decanal  (ISO)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (EXP)
disulfiram  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxifluridine  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
eugenol  (ISO)
fenpyroximate  (ISO)
Fidarestat  (ISO)
fipronil  (ISO)
fluoranthene  (ISO)
flutamide  (ISO)
folic acid  (EXP)
fonofos  (ISO)
fructosamine  (ISO)
fructose  (ISO)
galactose  (EXP)
gentamycin  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glyceraldehyde  (ISO)
glycine betaine  (ISO)
glyoxal  (ISO)
glyphosate  (ISO)
hept-2-enal  (ISO)
heptanal  (ISO)
hexanal  (ISO)
hexane  (ISO)
hexane-2,3-dione  (ISO)
hypochlorous acid  (EXP)
indometacin  (ISO)
inulin  (EXP)
isatin  (ISO)
isoeugenol  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
lead diacetate  (ISO)
lipopolysaccharide  (EXP,ISO)
LY294002  (ISO)
maneb  (EXP)
manganese(II) chloride  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methapyrilene  (ISO)
methyl salicylate  (ISO)
methylglyoxal  (ISO)
methylphenidate  (EXP)
methylseleninic acid  (ISO)
microcystin-LR  (EXP)
morphine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naphthalenes  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
non-2-enal  (ISO)
nonanal  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
oct-2-enal  (ISO)
octanal  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
pentanal  (ISO)
pentane-2,3-dione  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (EXP,ISO)
Phenylglyoxal  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
propan-2-ol  (ISO)
propanal  (ISO)
prostaglandin E2  (ISO)
pterostilbene  (EXP)
pyrimidifen  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (EXP)
sodium dodecyl sulfate  (ISO)
sorbinil  (ISO)
streptozocin  (ISO)
sulindac  (ISO)
sulindac sulfone  (ISO)
sunitinib  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (ISO)
trans-isoeugenol  (ISO)
tributylstannane  (EXP)
Triptolide  (ISO)
triptonide  (EXP)
valproic acid  (EXP,ISO)
vitamin E  (ISO)
zearalenone  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A systematic meta-analysis of genetic association studies for diabetic retinopathy. Abhary S, etal., Diabetes. 2009 Sep;58(9):2137-47. doi: 10.2337/db09-0059. Epub 2009 Jul 8.
2. Gel-based proteomics of liver cancer progression in rat. Albrethsen J, etal., Biochim Biophys Acta. 2011 Oct;1814(10):1367-76. Epub 2011 Jun 6.
3. Association analysis of nine candidate gene polymorphisms in Indian patients with type 2 diabetic retinopathy. Balasubbu S, etal., BMC Med Genet. 2010 Nov 10;11:158. doi: 10.1186/1471-2350-11-158.
4. Aldose reductase inhibitor zopolrestat restores allergic hyporesponsiveness in alloxan-diabetic rats. Carvalho VF, etal., Eur J Pharmacol. 2006 Nov 7;549(1-3):173-8. Epub 2006 Aug 26.
5. Mechanical hyperalgesia in rat models of systemic and local hyperglycemia. Dobretsov M, etal., Brain Res. 2003 Jan 17;960(1-2):174-83.
6. Polymorphism in the 5'-end of the aldose reductase gene is strongly associated with the development of diabetic nephropathy in type I diabetes. Heesom AE, etal., Diabetes. 1997 Feb;46(2):287-91.
7. Susceptibility to diabetic neuropathy in patients with insulin dependent diabetes mellitus is associated with a polymorphism at the 5' end of the aldose reductase gene. Heesom AE, etal., J Neurol Neurosurg Psychiatry. 1998 Feb;64(2):213-6.
8. Aldose reductase-deficient mice develop nephrogenic diabetes insipidus. Ho HT, etal., Mol Cell Biol. 2000 Aug;20(16):5840-6.
9. Downregulation of renal TonEBP in hypokalemic rats. Jeon US, etal., Am J Physiol Renal Physiol. 2007 Apr 4;.
10. Topical aldose reductase inhibitor formulations for effective lens drug delivery in a rat model for sugar cataracts. Kador PF, etal., J Ocul Pharmacol Ther. 2007 Apr;23(2):116-23.
11. Redox activation of aldose reductase in the ischemic heart. Kaiserova K, etal., J Biol Chem. 2006 Jun 2;281(22):15110-20. Epub 2006 Mar 27.
12. Is sorbitol dehydrogenase gene expression affected by streptozotocin-diabetes in the rat? Kicic E and Palmer TN, Biochim Biophys Acta. 1994 May 25;1226(2):213-8.
13. [Expression of genes involved in retinoic acid biosynthesis in human gastric cancer]. Kropotova ES, etal., Mol Biol (Mosk). 2013 Mar-Apr;47(2):317-30.
14. Acetic acid aldose reductase inhibitors bearing a five-membered heterocyclic core with potent topical activity in a visual impairment rat model. La Motta C, etal., J Med Chem. 2008 Jun 12;51(11):3182-93. doi: 10.1021/jm701613h. Epub 2008 May 2.
15. Evaluation of the prostaglandin F synthase activity of human and bovine aldo-keto reductases: AKR1A1s complement AKR1B1s as potent PGF synthases. Lacroix Pepin N, etal., Prostaglandins Other Lipid Mediat. 2013 Oct;106:124-32. doi: 10.1016/j.prostaglandins.2013.05.005. Epub 2013 Jun 6.
16. Regulation of AKR1B1 by thyroid hormone and its receptors. Liao CS, etal., Mol Cell Endocrinol. 2009 Aug 13;307(1-2):109-17. doi: 10.1016/j.mce.2009.04.013. Epub 2009 May 5.
17. Synthesis of flavonoids and their effects on aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues. Lim SS, etal., J Pharm Pharmacol. 2001 May;53(5):653-68.
18. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
19. MGDs mouse GO annotations MGD data from the GO Consortium
20. MGD IEA MGD IEA
21. The unfolded protein response in lens epithelial cells from galactosemic rat lenses. Mulhern ML, etal., Invest Ophthalmol Vis Sci. 2006 Sep;47(9):3951-9.
22. Prevention of diabetes-induced albuminuria in transgenic rats overexpressing human aldose reductase. Ng DP, etal., Endocrine. 2002 Jun;18(1):47-56.
23. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
24. C(-106)T polymorphism of the aldose reductase gene and the progression rate of diabetic retinopathy. Olmos P, etal., Diabetes Res Clin Pract. 2006 Nov;74(2):175-82. Epub 2006 May 15.
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
27. Effect of quercetin on galactose-induced hyperglycaemic oxidative stress in hepatic and neuronal tissues of Wistar rats. Ramana BV, etal., Acta Diabetol. 2006 Dec;43(4):135-41.
28. Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition. Ramana KV, etal., Circulation. 2006 Oct 24;114(17):1838-46. Epub 2006 Oct 9.
29. Mouse MP Annotation Import Pipeline RGD automated import pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Aldose reductase gene expression is increased in diabetic nephropathy. Shah VO, etal., J Clin Endocrinol Metab 1997 Jul;82(7):2294-8.
33. Aldose reductase gene polymorphisms and susceptibility to microvascular complications in Type 2 diabetes. Sivenius K, etal., Diabet Med. 2004 Dec;21(12):1325-33.
34. A selective aldose reductase inhibitor of a new structural class prevents or reverses early retinal abnormalities in experimental diabetic retinopathy. Sun W, etal., Diabetes. 2006 Oct;55(10):2757-62.
35. Human aldose reductase expression accelerates diabetic atherosclerosis in transgenic mice. Vikramadithyan RK, etal., J Clin Invest. 2005 Sep;115(9):2434-43. Epub 2005 Aug 25.
36. Electron microscopic immunocytochemical evidence for the mechanism of blood-retinal barrier breakdown in galactosemic rats and its association with aldose reductase expression and inhibition. Vinores SA, etal., Exp Eye Res. 1993 Dec;57(6):723-35.
37. Additive effect of aldose reductase Z-4 microsatellite polymorphism and glycaemic control on cataract development in type 2 diabetes. Wang Y, etal., J Diabetes Complications. 2014 Mar-Apr;28(2):147-51. doi: 10.1016/j.jdiacomp.2013.10.011. Epub 2013 Oct 31.
38. Aldose reductase inhibition prevents endotoxin-induced uveitis in rats. Yadav UC, etal., Invest Ophthalmol Vis Sci. 2007 Oct;48(10):4634-42.
39. Inhibitory effects of astragaloside IV on diabetic peripheral neuropathy in rats. Yu J, etal., Can J Physiol Pharmacol. 2006 Jun;84(6):579-87.
40. Aldose reductase-mediated induction of epithelium-to-mesenchymal transition (EMT) in lens. Zablocki GJ, etal., Chem Biol Interact. 2011 May 30;191(1-3):351-6. doi: 10.1016/j.cbi.2011.02.005. Epub 2011 Feb 15.
Additional References at PubMed
PMID:3899099   PMID:3927587   PMID:6762206   PMID:7851421   PMID:9006894   PMID:9485485   PMID:9872926   PMID:9918813   PMID:10049784   PMID:10092857   PMID:10322639   PMID:10349636  
PMID:10922068   PMID:11032718   PMID:11042159   PMID:11076861   PMID:11130978   PMID:11132157   PMID:11217851   PMID:11278684   PMID:12477932   PMID:12904583   PMID:14681479   PMID:15226823  
PMID:15489334   PMID:15655294   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16249434   PMID:16449351   PMID:16804062   PMID:16919269   PMID:16956889   PMID:17293845   PMID:17381426  
PMID:17382209   PMID:17727625   PMID:17727843   PMID:18307411   PMID:18445591   PMID:18760274   PMID:19028703   PMID:19225051   PMID:19273550   PMID:19657391   PMID:19729598   PMID:19752229  
PMID:20093363   PMID:20112370   PMID:20142761   PMID:20143423   PMID:20348015   PMID:20410296   PMID:20538586   PMID:21267539   PMID:21276777   PMID:21306562   PMID:21565611   PMID:21677750  
PMID:21856412   PMID:21862448   PMID:21873635   PMID:22139184   PMID:22253613   PMID:22661511   PMID:22673621   PMID:22836764   PMID:23247009   PMID:23460857   PMID:23614016   PMID:23920367  
PMID:23928303   PMID:24021941   PMID:24066058   PMID:24161443   PMID:24474649   PMID:24997765   PMID:25520004   PMID:26098214   PMID:27033597   PMID:27052179   PMID:27960106   PMID:28111134  
PMID:28245920   PMID:28378742   PMID:29190815   PMID:29238976   PMID:29627295   PMID:30025084   PMID:30068389   PMID:30595499   PMID:30713523   PMID:32086945   PMID:33911281   PMID:34321999  
PMID:35894077   PMID:36293380   PMID:36658399   PMID:36766828   PMID:37044030   PMID:37142655   PMID:38355793   PMID:38373627   PMID:38776924  


Genomics

Comparative Map Data
Akr1b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39634,280,865 - 34,294,424 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl634,279,369 - 34,294,413 (-)EnsemblGRCm39 Ensembl
GRCm38634,303,930 - 34,317,489 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl634,302,434 - 34,317,478 (-)EnsemblGRCm38mm10GRCm38
MGSCv37634,253,930 - 34,267,489 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36634,234,092 - 34,247,629 (-)NCBIMGSCv36mm8
Celera634,300,847 - 34,314,402 (-)NCBICelera
Cytogenetic Map6B1NCBI
cM Map614.87NCBI
AKR1B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387134,442,350 - 134,459,239 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7134,442,356 - 134,459,284 (-)EnsemblGRCh38hg38GRCh38
GRCh377134,127,102 - 134,143,991 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367133,777,647 - 133,794,428 (-)NCBINCBI36Build 36hg18NCBI36
Build 347133,584,361 - 133,601,143NCBI
Celera7128,864,507 - 128,881,287 (-)NCBICelera
Cytogenetic Map7q33NCBI
HuRef7128,428,754 - 128,445,534 (-)NCBIHuRef
CHM1_17134,061,391 - 134,078,169 (-)NCBICHM1_1
T2T-CHM13v2.07135,750,388 - 135,767,276 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27133,471,421 - 133,488,201 (-)NCBI
Akr1b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8463,899,222 - 63,913,315 (-)NCBIGRCr8
mRatBN7.2462,932,033 - 62,946,126 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl462,932,031 - 62,946,157 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx467,882,584 - 67,896,684 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0463,798,307 - 63,812,409 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0462,200,710 - 62,214,808 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0461,706,866 - 61,720,959 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl461,706,864 - 61,720,956 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0461,426,190 - 61,440,279 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4461,645,438 - 61,659,530 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1461,921,567 - 61,935,660 (-)NCBI
Celera457,984,561 - 57,998,653 (-)NCBICelera
RH 3.4 Map4393.32RGD
Cytogenetic Map4q22NCBI
AKR1B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26171,258,419 - 171,275,280 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1723,268,674 - 23,285,469 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07126,400,861 - 126,417,756 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17138,907,448 - 138,924,317 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7138,912,953 - 138,924,095 (-)Ensemblpanpan1.1panPan2
AKR1B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1142,991,888 - 3,006,941 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl142,991,888 - 3,006,940 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha142,649,050 - 2,664,066 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0142,721,426 - 2,736,482 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl142,721,426 - 2,736,481 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1142,926,088 - 2,941,099 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0142,670,903 - 2,685,919 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0142,816,445 - 2,831,531 (+)NCBIUU_Cfam_GSD_1.0
Akr1b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511821,179,563 - 21,195,800 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365791,312,175 - 1,328,397 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKR1B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1814,684,036 - 14,752,310 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11814,593,516 - 14,752,316 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21815,596,806 - 15,614,673 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103226928
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121103,060,018 - 103,076,844 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21103,059,991 - 103,077,341 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666042271,394 - 288,078 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Akr1b1
825 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:816
Count of miRNA genes:495
Interacting mature miRNAs:581
Transcripts:ENSMUST00000102980, ENSMUST00000126991, ENSMUST00000136559, ENSMUST00000142761, ENSMUST00000154655
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
4140989Spqq2_msperm quality QTL 2 (mouse)Not determined1771159851711719Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080576983Mouse
1357520Axtq2_manxiety QTL 2 (mouse)Not determined6450382348703611Mouse
10043869Cia6a_mcollagen induced arthritis QTL 6a (mouse)Not determined61211797146118069Mouse
11252142Mom12_mModifier of Min 12 (mouse)63387226167872400Mouse
1301850Fglu_mfasting glucose (mouse)Not determined61771159851711719Mouse
4141749Obrq2_mobesity resistance QTL 2 (mouse)Not determined1275122146751333Mouse
1300959Lxw2_mlupus BXSB x NZW 2 (mouse)Not determined63387226167872400Mouse
1301724Pcd4ts1_mp-glycoprotein positive CD4 T cell subset 1 (mouse)Not determined61771159851711719Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
10412107Desp4_mdespair 4 (mouse)Not determined62004983054049830Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414773364675Mouse
4141988Obrq3_mobesity resistance QTL 3 (mouse)Not determined2829099362291115Mouse
11353841Bmiq3_mbody mass index QTL 3 (mouse)6450382348703611Mouse
11353840Bmiq2_mbody mass index QTL 2 (mouse)6450382345291115Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
11352717Obrq2a_mobesity resistance QTL 2a (mouse)63169434134847895Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
1300731Smdq3_msegregation of mitochondrial DNA QTL 3 (mouse)Not determined6424920638249325Mouse
12904940Edlmmq5_mextensor digitorum longus muscle mass QTL 5 (mouse)61961634653616346Mouse
15039372Nmrs22_mNAFLD-associated magnetic resonance shift 22 (mouse)6147633435476334Mouse
4141782Mrdq5_mmodifier of retinal degeneration QTL 5 (mouse)Not determined3282758578215957Mouse
12904943Tammq4_mtibialis anterior muscle mass QTL 4 (mouse)61961634653616346Mouse
10412213Sxbq2_mSGC/Knj cross B6 QTL 2 (mouse)Not determined61991268571299759Mouse
12880425V25Dq5_mvitamin D inactive form serum level QTL 5 (mouse)63267698066676980Mouse
1302051Sluc7_msusceptibility to lung cancer 7 (mouse)Not determined6929707443297168Mouse
4141454Obrq4_mobesity resistance QTL 4 (mouse)Not determined3170349965703611Mouse
14700690Ccs6_mcolon cancer susceptibility 6 (mouse)62377693457776934Mouse
27226726Tibmd7_mtibia midshaft diameter 7, 16 week (mouse)61769999953476985Mouse
12904952Gmmq4_mgastrocnemius muscle mass QTL 4 (mouse)61961634653616346Mouse
1357481Aaj2_manxiety in A/J 2 (mouse)Not determined6450382348703611Mouse
1301998Bts2_mbladder tumor susceptibility 2 (mouse)Not determined61275122146751333Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62499999979976983Mouse


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_009658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB016665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC164578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH006028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH007732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK028079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK138000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK139250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV301527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY394007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC021655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY749711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D32250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L39795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U29152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U36489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000102980   ⟹   ENSMUSP00000100045
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl634,280,869 - 34,294,413 (-)Ensembl
GRCm38.p6 Ensembl634,303,934 - 34,317,478 (-)Ensembl
Ensembl Acc Id: ENSMUST00000126991
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl634,286,728 - 34,294,365 (-)Ensembl
GRCm38.p6 Ensembl634,309,793 - 34,317,430 (-)Ensembl
Ensembl Acc Id: ENSMUST00000136559
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl634,284,558 - 34,294,376 (-)Ensembl
GRCm38.p6 Ensembl634,307,623 - 34,317,441 (-)Ensembl
Ensembl Acc Id: ENSMUST00000142761
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl634,280,869 - 34,283,622 (-)Ensembl
GRCm38.p6 Ensembl634,303,934 - 34,306,687 (-)Ensembl
Ensembl Acc Id: ENSMUST00000154655   ⟹   ENSMUSP00000114391
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl634,287,540 - 34,294,394 (-)Ensembl
GRCm38.p6 Ensembl634,310,605 - 34,317,459 (-)Ensembl
Ensembl Acc Id: ENSMUST00000201392
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl634,279,369 - 34,284,392 (-)Ensembl
GRCm38.p6 Ensembl634,302,434 - 34,307,457 (-)Ensembl
RefSeq Acc Id: NM_009658   ⟹   NP_033788
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39634,280,865 - 34,294,424 (-)NCBI
GRCm38634,303,930 - 34,317,489 (-)ENTREZGENE
MGSCv37634,253,930 - 34,267,489 (-)RGD
Celera634,300,847 - 34,314,402 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_033788   ⟸   NM_009658
- UniProtKB: O70130 (UniProtKB/Swiss-Prot),   Q99KC9 (UniProtKB/Swiss-Prot),   P45376 (UniProtKB/Swiss-Prot),   Q3UDY1 (UniProtKB/TrEMBL),   Q5U415 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000114391   ⟸   ENSMUST00000154655
Ensembl Acc Id: ENSMUSP00000100045   ⟸   ENSMUST00000102980
Protein Domains
NADP-dependent oxidoreductase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P45376-F1-model_v2 AlphaFold P45376 1-316 view protein structure

Promoters
RGD ID:6838914
Promoter ID:MM_KWN:45522
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Lung
Transcripts:OTTMUST00000035073
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36634,256,876 - 34,257,376 (-)MPROMDB
RGD ID:6838915
Promoter ID:MM_KWN:45523
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000074150,   OTTMUST00000035069,   OTTMUST00000035070,   OTTMUST00000035071,   OTTMUST00000035072
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36634,267,164 - 34,267,664 (-)MPROMDB
RGD ID:6889282
Promoter ID:EPDNEW_M8092
Type:initiation region
Name:Akr1b3-2_1
Description:Mus musculus aldo-keto reductase family 1, member B3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38634,317,443 - 34,317,503EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1353494 AgrOrtholog
Ensembl Genes ENSMUSG00000001642 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000102980 ENTREZGENE
  ENSMUST00000102980.11 UniProtKB/Swiss-Prot
  ENSMUST00000154655.2 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aldo/ket_reductase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldo/keto_reductase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADP_OxRdtase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADP_OxRdtase_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11677 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1353494 ENTREZGENE
NCBI Gene 11677 ENTREZGENE
PANTHER ALDO-KETO REDUCTASE FAMILY 1 MEMBER B1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALDO/KETO REDUCTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aldo_ket_red UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Akr1b1 PhenoGen
PIRSF AKR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ALDKETRDTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ALDOKETO_REDUCTASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51430 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ALDR_MOUSE UniProtKB/Swiss-Prot
  D3YVJ7_MOUSE UniProtKB/TrEMBL
  O70130 ENTREZGENE
  P45376 ENTREZGENE
  Q3TCL2_MOUSE UniProtKB/TrEMBL
  Q3UDY1 ENTREZGENE, UniProtKB/TrEMBL
  Q3ULP0_MOUSE UniProtKB/TrEMBL
  Q5U415 ENTREZGENE, UniProtKB/TrEMBL
  Q99KC9 ENTREZGENE
UniProt Secondary O70130 UniProtKB/Swiss-Prot
  Q99KC9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-05-15 Akr1b1  aldo-keto reductase family 1 member B  Akr1b3  aldo-keto reductase family 1, member B3 (aldose reductase)  Symbol and/or name updated 27372883 PROVISIONAL