Scd1 (stearoyl-Coenzyme A desaturase 1) - Rat Genome Database

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Gene: Scd1 (stearoyl-Coenzyme A desaturase 1) Mus musculus
Analyze
Symbol: Scd1
Name: stearoyl-Coenzyme A desaturase 1
RGD ID: 736587
MGI Page MGI
Description: Enables metal ion binding activity; palmitoyl-CoA 9-desaturase activity; and stearoyl-CoA 9-desaturase activity. Involved in several processes, including positive regulation of cold-induced thermogenesis; sterol homeostasis; and tarsal gland development. Acts upstream of or within several processes, including brown fat cell differentiation; monounsaturated fatty acid biosynthetic process; and white fat cell differentiation. Located in endoplasmic reticulum membrane. Is expressed in several structures, including adipose tissue; central nervous system; cranium; integumental system; and liver. Orthologous to human SCD (stearoyl-CoA desaturase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AA589638; ab; acyl-CoA desaturase 1; AI265570; asebia; delta(9)-desaturase 1; delta-9 desaturase 1; fatty acid desaturase 1; SC; Scd; Scd-; Scd-1; stearoyl-CoA desaturase 1
RGD Orthologs
Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391944,382,889 - 44,396,148 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1944,382,894 - 44,396,318 (-)EnsemblGRCm39 Ensembl
GRCm381944,394,450 - 44,407,709 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1944,394,455 - 44,407,879 (-)EnsemblGRCm38mm10GRCm38
MGSCv371944,468,940 - 44,482,199 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361944,447,766 - 44,460,864 (-)NCBIMGSCv36mm8
Celera1945,168,530 - 45,181,736 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1937.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+/-)-Aegeline  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-carnitine  (ISO)
(R)-noradrenaline  (ISO)
(RS)-coclaurine  (EXP)
(RS)-norcoclaurine  (EXP)
(S)-coclaurine  (EXP)
(S)-nicotine  (EXP)
1,2,3-trilinolenoylglycerol  (EXP)
1,2,3-trilinoleoylglycerol  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1,3,7,9-tetramethyluric acid  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4,6-trinitrotoluene  (ISO)
2,4-dinitrophenol  (EXP)
2,4-dinitrotoluene  (ISO)
2-butoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3,7-dihydropurine-6-thione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-phenylprop-2-enal  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-tert-Octylphenol  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
7,12-dimethyltetraphene  (ISO)
9-cis,11-trans-octadecadienoic acid  (EXP)
acetamide  (ISO)
Acetyl tributyl citrate  (EXP)
acrylamide  (EXP,ISO)
Actein  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (ISO)
alpha-Zearalanol  (ISO)
amiodarone  (EXP,ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
andrographolide  (EXP)
Aroclor 1254  (EXP)
arsenous acid  (EXP)
atorvastatin calcium  (ISO)
atrazine  (EXP,ISO)
barium sulfate  (ISO)
benomyl  (ISO)
benzalkonium chloride  (EXP)
benzo[a]pyrene  (EXP)
benzo[b]fluoranthene  (EXP)
benzofurans  (EXP)
benzylpenicillin  (EXP)
beta-hexachlorocyclohexane  (EXP)
beta-naphthoflavone  (EXP)
bexarotene  (EXP,ISO)
bezafibrate  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (ISO)
buspirone  (ISO)
Butylbenzyl phthalate  (EXP)
C60 fullerene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
cannabidiol  (EXP)
carbamazepine  (ISO)
carbon nanotube  (EXP)
ceric oxide  (ISO)
chenodeoxycholic acid  (EXP)
chlordecone  (EXP)
chloroprene  (EXP,ISO)
chloroquine  (ISO)
chlorothalonil  (EXP)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP)
choline  (EXP)
chrysene  (EXP)
cisplatin  (EXP,ISO)
clobetasol  (EXP)
clofibrate  (EXP,ISO)
clofibric acid  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corn oil  (ISO)
corticosterone  (ISO)
coumarin  (ISO)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (EXP)
cyclosporin A  (ISO)
cypermethrin  (EXP)
D-glucose  (EXP,ISO)
DDE  (EXP,ISO)
decabromodiphenyl ether  (EXP)
desmosterol  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
Di-n-octyl phthalate  (EXP)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (EXP)
diclofenac  (EXP)
diethyl maleate  (ISO)
diethyl phthalate  (EXP)
difenoconazole  (EXP)
dihydrogen  (EXP)
diiodine  (EXP)
Diisodecyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dioxygen  (ISO)
dipentyl phthalate  (ISO)
diprotium  (EXP)
diuron  (ISO)
doxorubicin  (ISO)
Elemicin  (EXP)
endosulfan  (ISO)
erythromycin A  (EXP)
ethanol  (EXP,ISO)
Ethyl icosapentate  (EXP)
fenarimol  (ISO)
fenofibrate  (EXP,ISO)
fentin chloride  (ISO)
fipronil  (ISO)
flutamide  (ISO)
folic acid  (EXP)
fructose  (EXP,ISO)
furan  (ISO)
gadolinium trichloride  (EXP,ISO)
gamma-hexachlorocyclohexane  (ISO)
Ganoderic acid A  (EXP)
gemfibrozil  (EXP,ISO)
gentamycin  (ISO)
ginsenoside Re  (EXP)
glucagon  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
glycerol 2-phosphate  (EXP)
glycidol  (ISO)
glycine betaine  (ISO)
glycyrrhizinic acid  (EXP)
glyphosate  (EXP)
guggulsterone  (EXP)
GW 3965  (EXP)
Heptachlor epoxide  (EXP)
hexadecanoic acid  (EXP,ISO)
Honokiol  (ISO)
hydrazine  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
inulin  (EXP)
ketamine  (ISO)
ketoconazole  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (EXP)
lead diacetate  (EXP)
lead(0)  (EXP)
limonene  (ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (EXP)
lovastatin  (EXP)
lutein  (EXP)
manganese(II) chloride  (ISO)
mercaptopurine  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
miconazole  (EXP)
Morroniside  (EXP)
Muraglitazar  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nefazodone  (ISO)
nicotine  (EXP)
nimesulide  (ISO)
NMN zwitterion  (EXP)
nordihydroguaiaretic acid  (ISO)
octadecanoic acid  (ISO)
oleic acid  (EXP)
orphenadrine  (ISO)
ozone  (EXP,ISO)
p-tert-Amylphenol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (EXP)
perfluorobutyric acid  (EXP)
perfluorodecanoic acid  (EXP)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (EXP)
perfluorohexanesulfonic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenethyl caffeate  (ISO)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
PhIP  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
potassium bromate  (ISO)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
procymidone  (EXP)
progesterone  (EXP)
propamocarb  (EXP)
propiconazole  (EXP,ISO)
purine-6-thiol  (ISO)
PX-866  (EXP)
Pyridostigmine bromide  (ISO)
reactive oxygen species  (ISO)
rebaudioside A  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (EXP)
rimonabant  (EXP)
ritodrine  (EXP)
rosiglitazone  (ISO)
rotenone  (ISO)
senecionine  (EXP)
sodium arsenite  (EXP)
sodium cholate  (EXP)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
Sodium oleate  (EXP)
starch  (EXP)
steviol  (EXP)
stevioside  (EXP)
streptozocin  (EXP,ISO)
sucrose  (EXP,ISO)
sulfadimethoxine  (ISO)
tamoxifen  (EXP,ISO)
taurine  (EXP)
tauroursodeoxycholic acid  (ISO)
Tesaglitazar  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetraphene  (EXP)
Theaflavin 3,3'-digallate  (EXP)
thioacetamide  (EXP,ISO)
titanium dioxide  (EXP,ISO)
tolcapone  (ISO)
topiramate  (ISO)
tremolite asbestos  (EXP)
triarachidonin  (EXP)
tributylstannane  (EXP)
Tributyltin oxide  (EXP)
trichloroethene  (EXP,ISO)
triclocarban  (ISO)
triolein  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
troglitazone  (EXP,ISO)
trovafloxacin  (EXP,ISO)
tunicamycin  (EXP)
valdecoxib  (ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
voriconazole  (ISO)
xanthohumol  (EXP)
yohimbine  (EXP)
zaragozic acid A  (ISO)
zearalenone  (EXP)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cholesterol homeostasis  (IAGP)
abnormal circulating cholesterol level  (IAGP)
abnormal cutaneous collagen fibril morphology  (IAGP)
abnormal cutaneous elastic fiber morphology  (IAGP)
abnormal dermal layer morphology  (IAGP)
abnormal dermis papillary layer morphology  (IEA)
abnormal eating behavior  (IAGP)
abnormal epididymal fat pad morphology  (IAGP)
abnormal estrous cycle  (IAGP)
abnormal fat pad morphology  (IAGP)
abnormal gluconeogenesis  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal hair cycle  (IAGP)
abnormal hair follicle bulb morphology  (IAGP)
abnormal hair follicle development  (IAGP)
abnormal hair follicle inner root sheath morphology  (IAGP)
abnormal hair follicle matrix region morphology  (IEA)
abnormal hair follicle morphology  (IAGP)
abnormal hair follicle outer root sheath morphology  (IAGP)
abnormal hair growth  (IAGP)
abnormal hair shaft morphology  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal lipid level  (IAGP)
abnormal liver physiology  (IAGP)
abnormal metabolism  (IEA)
abnormal piliary canal morphology  (IEA)
abnormal reproductive system physiology  (IAGP)
abnormal sebaceous lipid secretion  (IAGP)
abnormal sebocyte morphology  (IAGP)
abnormal skin condition  (IAGP)
abnormal skin morphology  (IAGP)
abnormal skin physiology  (IAGP)
abnormal skin sebaceous gland morphology  (IAGP)
abnormal triglyceride level  (IAGP)
abnormal uterine fat pad morphology  (IAGP)
acanthosis  (IAGP)
alopecia  (IAGP)
blindness  (IAGP)
decreased circulating cholesterol level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased circulating VLDL cholesterol level  (IAGP)
decreased circulating VLDL triglyceride level  (IAGP)
decreased gonadal fat pad weight  (IAGP)
decreased hair follicle number  (IAGP)
decreased inguinal fat pad weight  (IAGP)
decreased liver glycogen level  (IAGP)
decreased liver triglyceride level  (IAGP)
decreased percent body fat/body weight  (IAGP)
decreased retroperitoneal fat pad weight  (IAGP)
decreased skin tensile strength  (IAGP)
decreased susceptibility to diet-induced hepatic steatosis  (IAGP)
decreased susceptibility to diet-induced obesity  (IAGP)
decreased unsaturated fatty acids level  (IAGP)
decreased white adipose tissue amount  (IAGP)
distorted hair follicle pattern  (IAGP)
dry skin  (IAGP)
enlarged hair follicles  (IAGP)
eyelids fail to open  (IAGP)
flaky skin  (IAGP)
granulomatous inflammation  (IAGP)
hair follicle degeneration  (IEA)
hunched posture  (IAGP)
hyperkeratosis  (IAGP)
impaired skin barrier function  (IAGP)
improved glucose tolerance  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating ketone body level  (IAGP)
increased fluid intake  (IAGP)
increased food intake  (IAGP)
increased insulin sensitivity  (IAGP)
increased oxygen consumption  (IAGP)
increased saturated fatty acids level  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
matted coat  (IAGP)
Meibomian gland atrophy  (IAGP)
narrow eye opening  (IAGP)
orthokeratosis  (IAGP)
parakeratosis  (IAGP)
photophobia  (IEA)
polyphagia  (IAGP)
polyuria  (IAGP)
postnatal growth retardation  (IAGP)
progressive hair loss  (IAGP)
prolonged diestrus  (IAGP)
reduced female fertility  (IAGP)
scaly skin  (IAGP)
sebaceous gland atrophy  (IAGP)
sebaceous gland hypoplasia  (IAGP)
short hair  (IAGP)
slow postnatal weight gain  (IAGP)
small Meibomian gland  (IAGP)
small perianal sebaceous gland  (IAGP)
small sebaceous gland  (IAGP)
sparse hair  (IAGP)
spontaneous skin ulceration  (IAGP)
thick dermal layer  (IAGP)
thick epidermis  (IAGP)
wrinkled skin  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Fermented rice bran supplementation mitigates metabolic syndrome in stroke-prone spontaneously hypertensive rats. Alauddin M, etal., BMC Complement Altern Med. 2016 Nov 8;16(1):442. doi: 10.1186/s12906-016-1427-z.
2. Arctium lappa L. polysaccharide can regulate lipid metabolism in type 2 diabetic rats through the SREBP-1/SCD-1 axis. Chen M, etal., Carbohydr Res. 2020 Aug;494:108055. doi: 10.1016/j.carres.2020.108055. Epub 2020 Jun 7.
3. Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice. Doddapattar P, etal., Mol Nutr Food Res. 2013 Oct;57(10):1718-28. doi: 10.1002/mnfr.201200794. Epub 2013 May 3.
4. Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome. Hao CL, etal., J Food Biochem. 2019 Mar;43(3):e12769. doi: 10.1111/jfbc.12769. Epub 2019 Jan 13.
5. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6. Therapeutic Effect of Gypenosides on Nonalcoholic Steatohepatitis via Regulating Hepatic Lipogenesis and Fatty Acid Oxidation. Li H, etal., Biol Pharm Bull. 2017;40(5):650-657. doi: 10.1248/bpb.b16-00942.
7. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
8. MGDs mouse GO annotations MGD data from the GO Consortium
9. MGD IEA MGD IEA
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Gene expression profiling in skeletal muscle of Zucker diabetic fatty rats: implications for a role of stearoyl-CoA desaturase 1 in insulin resistance. Voss MD, etal., Diabetologia. 2005 Dec;48(12):2622-30. Epub 2005 Nov 12.
14. (-)-Epigallocatechin-3-Gallate Ameliorates Atherosclerosis and Modulates Hepatic Lipid Metabolic Gene Expression in Apolipoprotein E Knockout Mice: Involvement of TTC39B. Wang W, etal., Front Pharmacol. 2018 Mar 9;9:195. doi: 10.3389/fphar.2018.00195. eCollection 2018.
15. Lipogenesis in fetal rat lung: importance of C/EBPalpha, SREBP-1c, and stearoyl-CoA desaturase. Zhang F, etal., Am J Respir Cell Mol Biol 2004 Feb;30(2):174-83. Epub 2003 Aug 01.
16. Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis. Zhang H, etal., PLoS One. 2015 Sep 22;10(9):e0138203. doi: 10.1371/journal.pone.0138203. eCollection 2015.
17. Dingxin Recipe IV attenuates atherosclerosis by regulating lipid metabolism through LXR-α/SREBP1 pathway and modulating the gut microbiota in ApoE-/- mice fed with HFD. Zhang Y, etal., J Ethnopharmacol. 2021 Feb 10;266:113436. doi: 10.1016/j.jep.2020.113436. Epub 2020 Oct 1.
Additional References at PubMed
PMID:631559   PMID:1319776   PMID:1322500   PMID:1350282   PMID:1684180   PMID:2013688   PMID:2903162   PMID:3998439   PMID:5774889   PMID:5924301   PMID:7678489   PMID:7738386  
PMID:7803821   PMID:7835879   PMID:8541340   PMID:8729090   PMID:8790349   PMID:8833906   PMID:8889548   PMID:8954132   PMID:9109606   PMID:9155951   PMID:9256466   PMID:9328433  
PMID:9507200   PMID:9530639   PMID:9689914   PMID:10087301   PMID:10201521   PMID:10349636   PMID:10441746   PMID:10464095   PMID:10484602   PMID:10545106   PMID:10545940   PMID:10854228  
PMID:10899171   PMID:10982846   PMID:11042159   PMID:11076861   PMID:11090130   PMID:11161812   PMID:11172053   PMID:11441127   PMID:11500518   PMID:11533264   PMID:11544199   PMID:12114623  
PMID:12177411   PMID:12364560   PMID:12401889   PMID:12419843   PMID:12454277   PMID:12466851   PMID:12477932   PMID:12588883   PMID:12646202   PMID:12713573   PMID:12815040   PMID:12928439  
PMID:12960377   PMID:14522948   PMID:14579408   PMID:14610273   PMID:14662765   PMID:14668353   PMID:14681479   PMID:14683458   PMID:14755338   PMID:15066988   PMID:15096593   PMID:15180999  
PMID:15210843   PMID:15278437   PMID:15340109   PMID:15489334   PMID:15494611   PMID:15525534   PMID:15562249   PMID:15597075   PMID:15728386   PMID:15829484   PMID:15855315   PMID:15916750  
PMID:16040962   PMID:16141072   PMID:16141073   PMID:16275639   PMID:16368743   PMID:16443825   PMID:16602821   PMID:16801925   PMID:16804073   PMID:16829211   PMID:16829692   PMID:16943421  
PMID:17005996   PMID:17033839   PMID:17127673   PMID:17164424   PMID:17295720   PMID:17369521   PMID:17391062   PMID:17429444   PMID:17496333   PMID:17738154   PMID:17960025   PMID:18042664  
PMID:18054317   PMID:18079124   PMID:18249173   PMID:18381840   PMID:18492766   PMID:18599738   PMID:18644838   PMID:18719666   PMID:18788462   PMID:18799693   PMID:18832746   PMID:19002112  
PMID:19066317   PMID:19095997   PMID:19119140   PMID:19258494   PMID:19338759   PMID:19429677   PMID:19633360   PMID:19695343   PMID:19787047   PMID:19883709   PMID:19910642   PMID:20363835  
PMID:20603810   PMID:20655875   PMID:20920255   PMID:20923962   PMID:21205794   PMID:21267068   PMID:21478464   PMID:21573029   PMID:21628453   PMID:21658928   PMID:21677750   PMID:21856199  
PMID:21862590   PMID:21873635   PMID:21890736   PMID:21938009   PMID:22055502   PMID:22096492   PMID:22101133   PMID:22318315   PMID:22326222   PMID:22326531   PMID:22431519   PMID:22539624  
PMID:22669918   PMID:22871591   PMID:22872236   PMID:22912899   PMID:22916088   PMID:23012479   PMID:23221600   PMID:23271751   PMID:23451260   PMID:23620511   PMID:23637738   PMID:23727646  
PMID:23747827   PMID:23785402   PMID:23803969   PMID:23867797   PMID:23907538   PMID:23918045   PMID:23941875   PMID:23945440   PMID:24055053   PMID:24069385   PMID:24088802   PMID:24191036  
PMID:24296537   PMID:24356954   PMID:24548407   PMID:24566853   PMID:24684199   PMID:24876128   PMID:25023287   PMID:25130896   PMID:25147951   PMID:25409434   PMID:25555387   PMID:25675381  
PMID:25678624   PMID:25959085   PMID:26074075   PMID:26098317   PMID:26098370   PMID:26416771   PMID:26508642   PMID:26525535   PMID:26685326   PMID:26976120   PMID:27008858   PMID:27133129  
PMID:27146480   PMID:27188441   PMID:27307439   PMID:27312025   PMID:27416896   PMID:27477676   PMID:27609767   PMID:27632198   PMID:27659424   PMID:27689697   PMID:27751891   PMID:27834856  
PMID:28143772   PMID:28167773   PMID:28259688   PMID:28364022   PMID:28397284   PMID:28659287   PMID:28667176   PMID:28724430   PMID:28790196   PMID:29326439   PMID:29385670   PMID:29463801  
PMID:29688375   PMID:29965978   PMID:30063922   PMID:30074985   PMID:30118512   PMID:30139760   PMID:30228991   PMID:30389914   PMID:30470572   PMID:30791926   PMID:30818059   PMID:30845964  
PMID:30930246   PMID:31356236   PMID:31673045   PMID:31676951   PMID:31690632   PMID:31693883   PMID:31953260   PMID:31965762   PMID:31980623   PMID:32035613   PMID:32097464   PMID:32125933  
PMID:32470559   PMID:32554809   PMID:32961871   PMID:32978274   PMID:33059001   PMID:33153107   PMID:33207603   PMID:33229547   PMID:33374300   PMID:33406440   PMID:33599498   PMID:33690217  
PMID:33888555   PMID:34326208   PMID:34363355   PMID:34576047   PMID:35122619   PMID:35341816   PMID:35361962   PMID:35660131   PMID:35718096   PMID:35863637   PMID:36114818   PMID:36124130  
PMID:36507562   PMID:36529318   PMID:36899019   PMID:37054998   PMID:37315672   PMID:37715952   PMID:37852324   PMID:37879607   PMID:38113115   PMID:38244769   PMID:38354249   PMID:38485951  
PMID:38492843   PMID:38573852   PMID:38972757  


Genomics

Comparative Map Data
Scd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391944,382,889 - 44,396,148 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1944,382,894 - 44,396,318 (-)EnsemblGRCm39 Ensembl
GRCm381944,394,450 - 44,407,709 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1944,394,455 - 44,407,879 (-)EnsemblGRCm38mm10GRCm38
MGSCv371944,468,940 - 44,482,199 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361944,447,766 - 44,460,864 (-)NCBIMGSCv36mm8
Celera1945,168,530 - 45,181,736 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1937.98NCBI
Scd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81253,218,968 - 253,232,101 (-)NCBIGRCr8
mRatBN7.21243,269,745 - 243,282,878 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1243,269,747 - 243,282,562 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1251,420,000 - 251,432,600 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01258,116,587 - 258,129,187 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01250,770,154 - 250,782,754 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01264,159,966 - 264,173,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1264,160,129 - 264,172,729 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01271,602,885 - 271,615,985 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41249,458,860 - 249,471,460 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11249,717,543 - 249,730,359 (-)NCBI
Celera1239,084,889 - 239,097,489 (-)NCBICelera
Cytogenetic Map1q54NCBI

Variants

.
Variants in Scd1
460 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1365
Count of miRNA genes:636
Interacting mature miRNAs:814
Transcripts:ENSMUST00000041331
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
1302170Tanidd1_mtally ho associated non-insulin dependednt diabetes mellitus 1 (mouse)Not determined193675259761420004Mouse
1301466T2dm2_mtype 2 diabetes mellitus 2 (mouse)Not determined193837605061420004Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse
1302104Lfp1_mlong free running period 1 (mouse)Not determined193918406461420004Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse
14928311Manh85_mmandible shape 85 (mouse)191191478945914789Mouse
1301639Stnn_mstriatal neuron number (mouse)Not determined193395195261420004Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192542691759427005Mouse
1300683Fembm7_mfemoral bone morphometry 7 (mouse)Not determined193014122461420004Mouse
10043896Bw21_mbody weight QTL 21 (mouse)Not determined193959606661420004Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192137870555378928Mouse
4141019Tgq29_mtriglyceride QTL 29 (mouse)Not determined3459678661420004Mouse
1301942Pas13_mpulmonary adenoma susceptibility 13 (mouse)Not determined193014123161420004Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191492301648923138Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191829516252295381Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192498843958988439Mouse
1300856Nobq2_mNew Zealand obese QTL 2 (mouse)Not determined193089788061420004Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2814034861420004Mouse
4141650Chldq9_mcholesterol and HDL QTL 9 (mouse)Not determined193788298261420004Mouse
13504736Ifvrq6_minfluenza virus resistance QTL 6 (mouse)193690291044913949Mouse
1301410Cd8mts6_mCD8 memory T cell subset 6 (mouse)Not determined193014123161420004Mouse
1301479Sluc1_msusceptibility to lung cancer 1 (mouse)Not determined193601694446761521Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192023431454234461Mouse
1300585Pgia12_mproteoglycan induced arthritis 12 (mouse)Not determined194258685961420004Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191829516252295381Mouse
1301741Lith2_mlithogenic gene 2 (mouse)Not determined193299215861420004Mouse

Markers in Region
M21285  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381944,397,100 - 44,397,256UniSTSGRCm38
MGSCv371944,471,590 - 44,471,746UniSTSGRCm37
Celera1945,171,180 - 45,171,338UniSTS
Cytogenetic Map19C3UniSTS
cM Map1943.0UniSTS
Whitehead_YAC19 UniSTS
D18Mit29  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381944,407,680 - 44,407,829UniSTSGRCm38
MGSCv371944,482,170 - 44,482,319UniSTSGRCm37
Cytogenetic Map19C3UniSTS
cM Map1835.0UniSTS
cM Map19 UniSTS
Whitehead Genetic1819.7UniSTS
Whitehead_YAC18 UniSTS
D19Mit67  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381944,397,155 - 44,397,266UniSTSGRCm38
MGSCv371944,471,645 - 44,471,756UniSTSGRCm37
Celera1945,171,235 - 45,171,348UniSTS
Cytogenetic Map19C3UniSTS
cM Map1943.0UniSTS
Whitehead Genetic1932.8UniSTS
D19Mit67.2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381944,397,005 - 44,397,170UniSTSGRCm38
MGSCv371944,471,495 - 44,471,660UniSTSGRCm37
Celera1945,171,085 - 45,171,250UniSTS
Cytogenetic Map19C3UniSTS
cM Map1943.0UniSTS
cM Map19 UniSTS
Whitehead_YAC19 UniSTS
AI265570  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381944,394,637 - 44,394,876UniSTSGRCm38
MGSCv371944,469,127 - 44,469,366UniSTSGRCm37
Celera1945,168,717 - 45,168,956UniSTS
Cytogenetic Map19C3UniSTS
cM Map1943.0UniSTS
Whitehead/MRC_RH19435.0UniSTS
RH125028  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381944,395,030 - 44,395,316UniSTSGRCm38
MGSCv371944,469,520 - 44,469,806UniSTSGRCm37
Celera1945,169,110 - 45,169,396UniSTS
Cytogenetic Map19C3UniSTS
cM Map1943.0UniSTS
Scd1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371944,471,829 - 44,472,459UniSTSGRCm37
MGSCv371944,472,470 - 44,472,543UniSTSGRCm37
MGSCv371944,419,255 - 44,419,328UniSTSGRCm37
Celera1945,171,421 - 45,172,051UniSTS
Celera1945,172,062 - 45,172,135UniSTS
Celera1945,118,882 - 45,118,955UniSTS
Cytogenetic Map19C3UniSTS
cM Map1943.0UniSTS
D19Nds1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381944,397,113 - 44,397,283UniSTSGRCm38
MGSCv371944,471,603 - 44,471,773UniSTSGRCm37
Celera1945,171,193 - 45,171,365UniSTS
Cytogenetic Map19C3UniSTS
cM Map1943.0UniSTS
Scd1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19C3UniSTS
Scd1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381944,397,339 - 44,397,969UniSTSGRCm38
MGSCv371944,471,829 - 44,472,459UniSTSGRCm37
Celera1945,171,421 - 45,172,051UniSTS
Cytogenetic Map19C3UniSTS
Scd1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381944,397,980 - 44,398,053UniSTSGRCm38
GRCm381944,344,765 - 44,344,838UniSTSGRCm38
MGSCv371944,419,255 - 44,419,328UniSTSGRCm37
MGSCv371944,472,470 - 44,472,543UniSTSGRCm37
Celera1945,172,062 - 45,172,135UniSTS
Celera1945,118,882 - 45,118,955UniSTS
Cytogenetic Map19C3UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_009127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA881780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC123853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF509567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF509570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK012370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK078704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK135642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK142630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC055453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC114387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC114388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC114417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ885468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU053011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD544724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU017415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  ON054180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  ON054181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  ON054182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  ON054183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  ON054184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  ON054185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  ON054186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  ON054187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000041331   ⟹   ENSMUSP00000036936
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1944,382,894 - 44,396,148 (-)Ensembl
GRCm38.p6 Ensembl1944,394,455 - 44,407,709 (-)Ensembl
RefSeq Acc Id: ENSMUST00000235741   ⟹   ENSMUSP00000157730
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1944,395,124 - 44,396,318 (-)Ensembl
GRCm38.p6 Ensembl1944,406,685 - 44,407,879 (-)Ensembl
RefSeq Acc Id: ENSMUST00000236824
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1944,386,432 - 44,395,129 (-)Ensembl
GRCm38.p6 Ensembl1944,397,993 - 44,406,690 (-)Ensembl
RefSeq Acc Id: NM_009127   ⟹   NP_033153
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391944,382,889 - 44,396,148 (-)NCBI
GRCm381944,394,450 - 44,407,709 (-)ENTREZGENE
MGSCv371944,468,940 - 44,482,199 (-)RGD
Celera1945,168,530 - 45,181,736 (-)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_033153   ⟸   NM_009127
- UniProtKB: Q922I6 (UniProtKB/Swiss-Prot),   P13516 (UniProtKB/Swiss-Prot),   Q547C4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000036936   ⟸   ENSMUST00000041331
RefSeq Acc Id: ENSMUSP00000157730   ⟸   ENSMUST00000235741
Protein Domains
Fatty acid desaturase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13516-F1-model_v2 AlphaFold P13516 1-355 view protein structure

Promoters
RGD ID:13679586
Promoter ID:EPDNEW_M23942
Type:multiple initiation site
Name:Scd1_2
Description:Mus musculus stearoyl-Coenzyme A desaturase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M23943  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381944,407,561 - 44,407,621EPDNEW
RGD ID:13679588
Promoter ID:EPDNEW_M23943
Type:initiation region
Name:Scd1_1
Description:Mus musculus stearoyl-Coenzyme A desaturase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M23942  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381944,407,708 - 44,407,768EPDNEW
RGD ID:6829868
Promoter ID:MM_KWN:27161
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   Brain,   Kidney,   Liver,   Lung,   Spleen
Transcripts:UC008HPS.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361944,469,856 - 44,471,307 (+)MPROMDB
RGD ID:6830385
Promoter ID:MM_KWN:27162
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_009127
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361944,481,856 - 44,483,037 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98239 AgrOrtholog
Ensembl Genes ENSMUSG00000037071 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000041331 ENTREZGENE
  ENSMUST00000041331.4 UniProtKB/Swiss-Prot
  ENSMUST00000235741.2 UniProtKB/TrEMBL
InterPro Acyl-CoA_DS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FA_desaturase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FADS-1_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20249 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:98239 ENTREZGENE
NCBI Gene 20249 ENTREZGENE
PANTHER ACYL-COA DESATURASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11351 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FA_desaturase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Scd1 PhenoGen
PRINTS FACDDSATRASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FATTY_ACID_DESATUR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A494B9N5_MOUSE UniProtKB/TrEMBL
  ACOD1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UXG5_MOUSE UniProtKB/TrEMBL
  Q547C4 ENTREZGENE, UniProtKB/TrEMBL
  Q922I6 ENTREZGENE
UniProt Secondary Q922I6 UniProtKB/Swiss-Prot