Slc22a5 (solute carrier family 22 (organic cation transporter), member 5) - Rat Genome Database

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Gene: Slc22a5 (solute carrier family 22 (organic cation transporter), member 5) Mus musculus
Analyze
Symbol: Slc22a5
Name: solute carrier family 22 (organic cation transporter), member 5
RGD ID: 736544
MGI Page MGI
Description: Enables (R)-carnitine transmembrane transporter activity and sodium ion transmembrane transporter activity. Involved in several processes, including (R)-carnitine transmembrane transport; response to tumor necrosis factor; and response to type II interferon. Acts upstream of or within several processes, including adult heart development; carnitine metabolic process; and carnitine transport. Located in apical plasma membrane and brush border membrane. Is active in plasma membrane. Is expressed in several structures, including liver; metanephros; nasal cavity mucosa; spleen; and testis. Used to study systemic primary carnitine deficiency disease. Human ortholog(s) of this gene implicated in Crohn's disease; cardiomyopathy; inherited metabolic disorder; and systemic primary carnitine deficiency disease. Orthologous to human SLC22A5 (solute carrier family 22 member 5).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: high-affinity sodium-dependent carnitine cotransporter; juvenile visceral steatosis; jvs; L; Lstp-like; Lstpl; Oct; Octn2; organic cation/carnitine transporter 2; solute carrier family 22 member 5
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,755,368 - 53,782,609 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,755,368 - 53,782,486 (-)EnsemblGRCm39 Ensembl
GRCm381153,864,542 - 53,891,796 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,864,542 - 53,891,660 (-)EnsemblGRCm38mm10GRCm38
MGSCv371153,678,044 - 53,705,205 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361153,707,965 - 53,735,083 (-)NCBIMGSCv36mm8
Celera1158,444,145 - 58,471,434 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1132.02NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (ISO)
(R)-carnitine  (EXP,ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (EXP,ISO)
amiodarone  (ISO)
angelicin  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
aristolochic acids  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
Azoxymethane  (EXP)
benzo[a]pyrene  (EXP)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bromobenzene  (ISO)
buta-1,3-diene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
CAR(3:0(Me2))  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
carebastine  (EXP)
carmustine  (ISO)
cefaloridine  (ISO)
CGP 52608  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (EXP)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (ISO)
clozapine  (ISO)
Cuprizon  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyproheptadine  (EXP)
decabromodiphenyl ether  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dichloroacetic acid  (EXP)
diphenhydramine  (EXP)
dithioerythritol  (ISO)
doxorubicin  (EXP,ISO)
dronedarone  (EXP)
Ebastine  (EXP)
enilconazole  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (EXP)
fructose  (ISO)
gemfibrozil  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
glycine betaine  (ISO)
graphite  (ISO)
Grepafloxacin  (ISO)
hydroxyurea  (ISO)
ifosfamide  (ISO)
imperatorin  (EXP)
inulin  (EXP)
ipratropium  (ISO)
isoimperatorin  (EXP)
L-cysteine  (ISO)
leflunomide  (ISO)
lenvatinib  (EXP,ISO)
lidocaine  (ISO)
mangiferin  (EXP)
meldonium  (ISO)
mepyramine  (EXP)
mercury dichloride  (ISO)
metformin  (ISO)
methoxsalen  (EXP)
methoxychlor  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
nifedipine  (ISO)
ofloxacin  (ISO)
olanzapine  (EXP,ISO)
omeprazole  (ISO)
oxaliplatin  (ISO)
oxycodone  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (EXP)
perfluorohexanesulfonic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (EXP)
phenformin  (ISO)
phenobarbital  (EXP)
pirinixic acid  (EXP,ISO)
Potassium 2,6-dihydroxytriazinecarboxylate  (EXP)
pravastatin  (EXP,ISO)
probenecid  (EXP)
progesterone  (ISO)
promethazine  (EXP)
propiconazole  (EXP)
propranolol  (ISO)
psoralen  (EXP)
quercetin  (EXP,ISO)
quetiapine fumarate  (ISO)
raloxifene  (ISO)
rotenone  (ISO)
sodium arsenite  (ISO)
spironolactone  (ISO)
sunitinib  (ISO)
talinolol  (ISO)
tamoxifen  (EXP)
temozolomide  (ISO)
Tesaglitazar  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (ISO)
tetraethylammonium  (ISO)
tetrahydropalmatine  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
toluene  (ISO)
trans-piceid  (EXP)
trichloroethene  (EXP)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
urethane  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
verapamil  (ISO)
vorinostat  (ISO)
zaragozic acid A  (EXP,ISO)
zidovudine  (ISO)
ziprasidone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Downregulation of carnitine acyltransferases and organic cation transporter OCTN2 in mononuclear cells in healthy elderly and patients with myelodysplastic syndromes. Karlic H, etal., J Mol Med. 2003 Jul;81(7):435-42. Epub 2003 Jun 12.
2. Successful carnitine treatment in two siblings having lipid storage myopathy with hypertrophic cardiomyopathy. Matsuishi T, etal., Neuropediatrics. 1985 Feb;16(1):6-12.
3. Phenotypic manifestations of the OCTN2 V295X mutation: sudden infant death and carnitine-responsive cardiomyopathy in Roma families. Melegh B, etal., Am J Med Genet A. 2004 Dec 1;131(2):121-6.
4. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. L-Carnitine prevents the development of ventricular fibrosis and heart failure with preserved ejection fraction in hypertensive heart disease. Omori Y, etal., J Hypertens. 2012 Sep;30(9):1834-44. doi: 10.1097/HJH.0b013e3283569c5a.
10. The Protective Effect of Cynara Cardunculus Extract in Diet-Induced NAFLD: Involvement of OCTN1 and OCTN2 Transporter Subfamily. Oppedisano F, etal., Nutrients. 2020 May 15;12(5):1435. doi: 10.3390/nu12051435.
11. Functional variants of OCTN cation transporter genes are associated with Crohn disease. Peltekova VD, etal., Nat Genet. 2004 May;36(5):471-5. Epub 2004 Apr 11.
12. Cigarette smoke extract combined with lipopolysaccharide reduces OCTN1/2 expression in human alveolar epithelial cells in vitro and rat lung in vivo under inflammatory conditions. Qi C, etal., Int Immunopharmacol. 2020 Oct;87:106812. doi: 10.1016/j.intimp.2020.106812. Epub 2020 Jul 21.
13. Identification of two novel mutations in OCTN2 from two Saudi patients with systemic carnitine deficiency. Rahbeeni Z, etal., J Inherit Metab Dis. 2002 Sep;25(5):363-9.
14. Mouse MP Annotation Import Pipeline RGD automated import pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1383034   PMID:1540663   PMID:1996978   PMID:3352223   PMID:7626891   PMID:7671812   PMID:7773507   PMID:7914432   PMID:8155735   PMID:8325377   PMID:8605222   PMID:8660978  
PMID:8670273   PMID:8830050   PMID:8858199   PMID:8889548   PMID:8985169   PMID:9058209   PMID:9140816   PMID:9149945   PMID:9187371   PMID:9212045   PMID:9634010   PMID:9837751  
PMID:9916797   PMID:10087008   PMID:10100867   PMID:10349636   PMID:10454528   PMID:10498652   PMID:10525100   PMID:10562461   PMID:10609898   PMID:10655497   PMID:10704283   PMID:10922068  
PMID:11010964   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11257506   PMID:12175785   PMID:12477932   PMID:12535646   PMID:12549821   PMID:12612434   PMID:14595704   PMID:14610273  
PMID:15056854   PMID:15240869   PMID:15369770   PMID:15489334   PMID:15523054   PMID:15782199   PMID:15896819   PMID:15963478   PMID:16141072   PMID:16141073   PMID:16540195   PMID:16546150  
PMID:16734862   PMID:16754783   PMID:16870721   PMID:17027329   PMID:17576045   PMID:17664396   PMID:17692817   PMID:17884651   PMID:17978498   PMID:18296741   PMID:18322073   PMID:18574325  
PMID:19233567   PMID:19521566   PMID:19744557   PMID:19819229   PMID:19899138   PMID:20558736   PMID:20722056   PMID:21190881   PMID:21267068   PMID:21321536   PMID:21641380   PMID:21677750  
PMID:21873635   PMID:22454430   PMID:23112839   PMID:25505152   PMID:26416771   PMID:28668962   PMID:30213487   PMID:30465787   PMID:31845336   PMID:32070725   PMID:35733999   PMID:36293168  
PMID:38355793  


Genomics

Comparative Map Data
Slc22a5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,755,368 - 53,782,609 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,755,368 - 53,782,486 (-)EnsemblGRCm39 Ensembl
GRCm381153,864,542 - 53,891,796 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,864,542 - 53,891,660 (-)EnsemblGRCm38mm10GRCm38
MGSCv371153,678,044 - 53,705,205 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361153,707,965 - 53,735,083 (-)NCBIMGSCv36mm8
Celera1158,444,145 - 58,471,434 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1132.02NCBI
SLC22A5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385132,369,710 - 132,395,612 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5132,369,710 - 132,395,613 (+)EnsemblGRCh38hg38GRCh38
GRCh375131,705,402 - 131,731,304 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365131,733,343 - 131,759,205 (+)NCBINCBI36Build 36hg18NCBI36
Build 345131,733,342 - 131,759,202NCBI
Celera5127,835,468 - 127,861,380 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5126,897,648 - 126,923,551 (+)NCBIHuRef
CHM1_15131,138,142 - 131,164,051 (+)NCBICHM1_1
T2T-CHM13v2.05132,889,604 - 132,915,514 (+)NCBIT2T-CHM13v2.0
Slc22a5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81038,509,072 - 38,536,240 (-)NCBIGRCr8
mRatBN7.21038,008,303 - 38,035,474 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1038,008,311 - 38,035,309 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1042,700,243 - 42,727,196 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01042,190,330 - 42,217,283 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01037,694,042 - 37,720,998 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01039,201,101 - 39,228,090 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1039,201,107 - 39,323,853 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01038,982,882 - 39,009,871 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,311,729 - 39,338,718 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11039,325,353 - 39,352,341 (-)NCBI
Celera1037,351,299 - 37,378,255 (-)NCBICelera
Cytogenetic Map10q22NCBI
SLC22A5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24127,687,274 - 127,713,176 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15125,826,838 - 125,852,355 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05127,791,984 - 127,817,870 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15133,954,549 - 133,980,410 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5133,954,678 - 133,979,066 (+)Ensemblpanpan1.1panPan2
SLC22A5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11120,659,023 - 20,686,359 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1120,598,888 - 20,683,087 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1119,460,877 - 19,488,092 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01121,444,805 - 21,472,095 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1121,384,549 - 21,469,234 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11120,163,703 - 20,190,915 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01120,011,714 - 20,038,930 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01120,653,571 - 20,680,804 (+)NCBIUU_Cfam_GSD_1.0
Slc22a5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213115,771,008 - 115,795,734 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366472,773,768 - 2,798,511 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366472,774,063 - 2,798,585 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC22A5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2134,660,808 - 134,686,219 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12134,660,741 - 134,847,575 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140,064,363 - 140,150,841 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC22A5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12335,197,909 - 35,224,466 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2335,197,985 - 35,223,137 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603442,719,642 - 42,746,187 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc22a5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473339,698,456 - 39,808,718 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473339,690,958 - 39,727,503 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc22a5
727 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:979
Count of miRNA genes:520
Interacting mature miRNAs:626
Transcripts:ENSMUST00000019044, ENSMUST00000136307, ENSMUST00000152084
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
10053675Eae44b_mexperimental allergic encephalomyelitis susceptibility 44b (mouse)Not determined113995072854094448Mouse
4142475Ity2a_mimmunity to S. typhimurium 2a (mouse)Not determined113776858060402716Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
14746971Manh70_mmandible shape 70 (mouse)111990589053905890Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
4141398Tgq22_mtriglyceride QTL 22 (mouse)Not determined2116340655163406Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1300713Vmbic10_mventral midbrain iron content 10 (mouse)Not determined114277262654081064Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112577262659772741Mouse

Markers in Region
Slc22a5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381153,864,943 - 53,865,412UniSTSGRCm38
MGSCv371153,678,445 - 53,678,914UniSTSGRCm37
Celera1158,444,546 - 58,445,015UniSTS
Cytogenetic Map11B1.3UniSTS
cM Map1128.0UniSTS
UniSTS:236575  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381153,949,990 - 53,950,306UniSTSGRCm38
GRCm381153,864,571 - 53,864,886UniSTSGRCm38
MGSCv371153,763,492 - 53,763,808UniSTSGRCm37
MGSCv371153,678,073 - 53,678,388UniSTSGRCm37
Celera1158,444,174 - 58,444,489UniSTS
Celera1158,530,043 - 58,530,359UniSTS
Cytogenetic Map11B1.3UniSTS
UniSTS:236576  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381153,950,590 - 53,950,673UniSTSGRCm38
GRCm381153,865,170 - 53,865,253UniSTSGRCm38
MGSCv371153,764,092 - 53,764,175UniSTSGRCm37
MGSCv371153,678,672 - 53,678,755UniSTSGRCm37
Celera1158,444,773 - 58,444,856UniSTS
Celera1158,530,643 - 58,530,726UniSTS
Cytogenetic Map11B1.3UniSTS
AU047818  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381153,878,924 - 53,879,103UniSTSGRCm38
MGSCv371153,692,426 - 53,692,605UniSTSGRCm37
Celera1158,458,527 - 58,458,706UniSTS
Cytogenetic Map11B1.3UniSTS
Slc22a5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B1.3UniSTS
Slc22a5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B1.3UniSTS
cM Map1128.0UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001362711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001362712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001425415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001425416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001425417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001425418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001425419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001425420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001425421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001425422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001425423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006532650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB015800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF110417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF111425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI428340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK140640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK188702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL596182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY017275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GN007401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000019044   ⟹   ENSMUSP00000019044
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1153,755,368 - 53,782,486 (-)Ensembl
GRCm38.p6 Ensembl1153,864,542 - 53,891,660 (-)Ensembl
Ensembl Acc Id: ENSMUST00000136307   ⟹   ENSMUSP00000118900
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1153,764,505 - 53,782,421 (-)Ensembl
GRCm38.p6 Ensembl1153,873,679 - 53,891,595 (-)Ensembl
Ensembl Acc Id: ENSMUST00000152084   ⟹   ENSMUSP00000115474
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1153,756,291 - 53,762,503 (-)Ensembl
GRCm38.p6 Ensembl1153,865,465 - 53,871,677 (-)Ensembl
RefSeq Acc Id: NM_001362711   ⟹   NP_001349640
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391153,755,368 - 53,782,504 (-)NCBI
GRCm381153,864,542 - 53,891,703 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001362712   ⟹   NP_001349641
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391153,755,368 - 53,782,504 (-)NCBI
GRCm381153,864,542 - 53,891,703 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001425415   ⟹   NP_001412344
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391153,755,368 - 53,782,504 (-)NCBI
RefSeq Acc Id: NM_001425416   ⟹   NP_001412345
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391153,761,788 - 53,782,504 (-)NCBI
RefSeq Acc Id: NM_001425417   ⟹   NP_001412346
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391153,761,788 - 53,782,504 (-)NCBI
RefSeq Acc Id: NM_001425418   ⟹   NP_001412347
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391153,755,368 - 53,782,504 (-)NCBI
RefSeq Acc Id: NM_001425419   ⟹   NP_001412348
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391153,755,368 - 53,782,504 (-)NCBI
RefSeq Acc Id: NM_001425420   ⟹   NP_001412349
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391153,755,368 - 53,782,504 (-)NCBI
RefSeq Acc Id: NM_001425421   ⟹   NP_001412350
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391153,755,368 - 53,782,504 (-)NCBI
RefSeq Acc Id: NM_001425422   ⟹   NP_001412351
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391153,755,368 - 53,782,504 (-)NCBI
RefSeq Acc Id: NM_001425423   ⟹   NP_001412352
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391153,755,368 - 53,782,504 (-)NCBI
RefSeq Acc Id: NM_011396   ⟹   NP_035526
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391153,755,368 - 53,782,504 (-)NCBI
GRCm381153,864,542 - 53,891,703 (-)NCBI
MGSCv371153,678,044 - 53,705,205 (-)RGD
Celera1158,444,145 - 58,471,434 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006532650   ⟹   XP_006532713
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391153,755,368 - 53,782,609 (-)NCBI
GRCm381153,864,542 - 53,891,784 (-)NCBI
Sequence:
RefSeq Acc Id: NP_035526   ⟸   NM_011396
- Peptide Label: isoform 1
- UniProtKB: Q9Z0E8 (UniProtKB/Swiss-Prot),   Q5SX17 (UniProtKB/TrEMBL),   Q3USA0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006532713   ⟸   XM_006532650
- Peptide Label: isoform X1
- UniProtKB: Q3USA0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001349641   ⟸   NM_001362712
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001349640   ⟸   NM_001362711
- Peptide Label: isoform 2
Ensembl Acc Id: ENSMUSP00000115474   ⟸   ENSMUST00000152084
Ensembl Acc Id: ENSMUSP00000019044   ⟸   ENSMUST00000019044
Ensembl Acc Id: ENSMUSP00000118900   ⟸   ENSMUST00000136307
RefSeq Acc Id: NP_001412352   ⟸   NM_001425423
- Peptide Label: isoform 7
RefSeq Acc Id: NP_001412347   ⟸   NM_001425418
- Peptide Label: isoform 6
RefSeq Acc Id: NP_001412349   ⟸   NM_001425420
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001412351   ⟸   NM_001425422
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001412350   ⟸   NM_001425421
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001412344   ⟸   NM_001425415
- Peptide Label: isoform 3
- UniProtKB: Q3USA0 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001412348   ⟸   NM_001425419
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001412346   ⟸   NM_001425417
- Peptide Label: isoform 5
RefSeq Acc Id: NP_001412345   ⟸   NM_001425416
- Peptide Label: isoform 4
Protein Domains
Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z0E8-F1-model_v2 AlphaFold Q9Z0E8 1-557 view protein structure

Promoters
RGD ID:6822113
Promoter ID:MM_KWN:7409
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000071545
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361153,685,581 - 53,686,081 (-)MPROMDB
RGD ID:6822115
Promoter ID:MM_KWN:7410
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4
Transcripts:OTTMUST00000012569,   OTTMUST00000012570
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361153,705,021 - 53,705,697 (-)MPROMDB
RGD ID:8674636
Promoter ID:EPDNEW_M15349
Type:initiation region
Name:Slc22a5_1
Description:Mus musculus solute carrier family 22 , member 5 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381153,891,647 - 53,891,707EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1329012 AgrOrtholog
Ensembl Genes ENSMUSG00000018900 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000019044 ENTREZGENE
  ENSMUST00000019044.8 UniProtKB/Swiss-Prot
  ENSMUST00000136307.2 UniProtKB/TrEMBL
  ENSMUST00000152084.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro MFS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_sugar_transport-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Orgcat_transp/SVOP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S22A4/5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sugar_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20520 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1329012 ENTREZGENE
NCBI Gene 20520 ENTREZGENE
PANTHER SOLUTE CARRIER FAMILY 22 MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sugar_tr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB SLC22A5 RGD
PhenoGen Slc22a5 PhenoGen
PROSITE MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUGAR_TRANSPORT_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D6RH54_MOUSE UniProtKB/TrEMBL
  F6TNN8_MOUSE UniProtKB/TrEMBL
  Q3USA0 ENTREZGENE, UniProtKB/TrEMBL
  Q5SX17 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z0E8 ENTREZGENE, UniProtKB/Swiss-Prot