Gene: PTGER4 (prostaglandin E receptor 4) Homo sapiens
Symbol: PTGER4
Name: prostaglandin E receptor 4
Description: The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: EP4; EP4R; MGC126583; OTTHUMP00000119996; PGE receptor EP4 subtype; PGE receptor, EP4 subtype; PGE2 receptor EP4 subtype; prostaglandin E receptor 4 (subtype EP4); prostaglandin E2 receptor EP4 subtype; prostanoid EP4 receptor
Mus musculus (house mouse) : Ptger4 (prostaglandin E receptor 4 (subtype EP4))  MGI  AGR
Rattus norvegicus (Norway rat) : Ptger4 (prostaglandin E receptor 4)  AGR
Chinchilla lanigera (long-tailed chinchilla) : Ptger4 (prostaglandin E receptor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : PTGER4 (prostaglandin E receptor 4)
Canis lupus familiaris (dog) : PTGER4 (prostaglandin E receptor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptger4 (prostaglandin E receptor 4)
more info ...
Related Pseudogenes: PTGER4P1   PTGER4P2   PTGER4P3  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38540,679,930 - 40,740,932 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37540,680,032 - 40,696,962 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36540,715,789 - 40,729,594 (+)NCBINCBI36hg18NCBI36
Build 34540,715,788 - 40,729,592NCBI
Celera540,568,598 - 40,582,403 (+)NCBI
Cytogenetic Map5p13.1NCBI
HuRef540,632,020 - 40,645,825 (+)NCBIHuRef
CHM1_1540,681,992 - 40,695,797 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PTGER4
AGR Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736498
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2017-12-19
Status: ACTIVE