Ccne1 (cyclin E1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ccne1 (cyclin E1) Mus musculus
Analyze
Symbol: Ccne1
Name: cyclin E1
RGD ID: 736489
MGI Page MGI
Description: Enables cyclin-dependent protein serine/threonine kinase regulator activity; kinase activity; and protein kinase binding activity. Acts upstream of or within several processes, including DNA replication initiation; chromosome organization; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of cyclin E1-CDK2 complex. Is expressed in several structures, including brain; early conceptus; embryo ectoderm; eye; and spleen. Human ortholog(s) of this gene implicated in breast adenocarcinoma. Orthologous to human CCNE1 (cyclin E1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AW538188; CycE1; G1/S-specific cyclin-E1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39737,797,409 - 37,806,915 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl737,797,409 - 37,806,959 (-)EnsemblGRCm39 Ensembl
GRCm38738,097,984 - 38,107,490 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl738,097,984 - 38,107,534 (-)EnsemblGRCm38mm10GRCm38
MGSCv37738,883,003 - 38,892,509 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36737,806,744 - 37,816,090 (-)NCBIMGSCv36mm8
Celera733,255,165 - 33,271,131 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map725.35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-citrinin  (ISO)
(-)-demecolcine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
(Z)-3-butylidenephthalide  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
19-Nor-17alpha-pregn-5(10)-en-20-yne-3alpha,17beta-diol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2,6-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-butoxyethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,7-dihydropurine-6-thione  (ISO)
3-[(4-anilinophenyl)diazenyl]benzene-1-sulfonic acid  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methyladenine  (ISO)
3-methylcholanthrene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-nitrophenol  (EXP)
4-nonylphenol  (ISO)
5,7-dihydroxy-4'-methoxyflavone  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (ISO)
5-methoxypsoralen  (ISO)
6-Methoxyflavone  (ISO)
6-propyl-2-thiouracil  (ISO)
9-Methoxycamptothecin  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (ISO)
acteoside  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allose  (ISO)
alpha-amanitin  (EXP)
alvocidib  (ISO)
amitrole  (ISO)
amlodipine  (ISO)
ammonium chloride  (ISO)
amsacrine  (ISO)
andrographolide  (EXP,ISO)
androstane  (EXP)
aniline  (ISO)
antroquinonol  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
artesunate  (ISO)
Aspidin  (ISO)
atrazine  (ISO)
atropine  (ISO)
baicalein  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoates  (ISO)
berberine  (ISO)
bexarotene  (EXP)
bifenthrin  (ISO)
biotin  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (EXP,ISO)
BKM120  (ISO)
brassinolide  (ISO)
bromobenzene  (ISO)
budesonide  (EXP)
Butylparaben  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
cadmium acetate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calciol  (ISO)
camostat  (EXP)
camptothecin  (ISO)
cannabidiol  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
Cardanol  (ISO)
carmustine  (ISO)
cefaloridine  (ISO)
CGP 52608  (ISO)
chlorohydrocarbon  (ISO)
chlorpyrifos  (EXP)
choline  (EXP,ISO)
chromium(6+)  (ISO)
ciprofloxacin  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (EXP,ISO)
corticosterone  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
Cyclopamine  (EXP,ISO)
cyclosporin A  (ISO)
cyprodinil  (ISO)
D-glucose  (ISO)
daunorubicin  (ISO)
deguelin  (ISO)
deoxynivalenol  (EXP)
desferrioxamine B  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (EXP)
diclofenac  (ISO)
dieckol  (ISO)
dieldrin  (ISO)
diethanolamine  (EXP,ISO)
diethylstilbestrol  (EXP)
Dinitramine  (EXP)
dioscin  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
EHT 1864  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
estragole  (EXP,ISO)
estriol  (ISO)
ethanol  (EXP)
ethidium  (ISO)
fenhexamid  (ISO)
flavanones  (ISO)
fludioxonil  (ISO)
flumequine  (EXP)
fluoxetine  (EXP,ISO)
folic acid  (ISO)
FR900359  (ISO)
fraxetin  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gadolinium trichloride  (ISO)
gallic acid  (ISO)
gamma-linolenic acid  (ISO)
gamma-tocopherol  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
gingerol  (ISO)
ginsenoside Rg1  (ISO)
glucose  (ISO)
glyphosate  (ISO)
GW 3965  (ISO)
GW 4064  (ISO)
hexachlorobenzene  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP)
hydroquinone  (ISO)
hydroxyurea  (EXP,ISO)
Hypsiziprenol-A9  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
inulin  (EXP)
iodoacetic acid  (EXP)
Isoliensinine  (ISO)
isoprene  (ISO)
isosilybin A  (ISO)
kainic acid  (ISO)
lactacystin  (ISO)
lapatinib  (ISO)
lead diacetate  (EXP)
Licochalcone B  (ISO)
lidocaine  (EXP)
LY294002  (EXP,ISO)
lycopene  (ISO)
magnesium atom  (ISO)
malachite green cation  (ISO)
malathion  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
MeIQx  (EXP)
melatonin  (ISO)
menadione  (ISO)
mercaptopurine  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methimazole  (ISO)
methotrexate  (EXP,ISO)
methoxyacetic acid  (ISO)
methoxychlor  (ISO)
methyl isocyanate  (ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylparaben  (EXP,ISO)
mevalonic acid  (ISO)
mifepristone  (ISO)
ML-7  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monobenzyl phthalate  (EXP)
monoethyl phthalate  (EXP)
N-(6-acetamidohexyl)acetamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
naringin  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nitrofurazone  (ISO)
NMS-873  (ISO)
Nonylphenol  (ISO)
ochratoxin A  (EXP,ISO)
olaparib  (ISO)
oleanolic acid  (EXP,ISO)
oligomycin A  (EXP)
omacetaxine mepesuccinate  (ISO)
orlistat  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
Panduratin A  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
PCB138  (EXP)
PD 0325901  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylcholine  (ISO)
pinostrobin  (ISO)
pinosylvin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
procymidone  (ISO)
progesterone  (EXP)
propylparaben  (EXP,ISO)
pterostilbene  (ISO)
purine-6-thiol  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (EXP)
ribavirin  (ISO)
Ro 41-5253  (ISO)
rubitecan  (ISO)
Sanggenon C  (ISO)
SB 431542  (ISO)
Shikonin  (ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
silver(1+) nitrate  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sorafenib  (ISO)
spiromesifen  (ISO)
sulfadimethoxine  (ISO)
sulforaphane  (EXP)
sulindac  (ISO)
sunitinib  (ISO)
taiwanin C  (EXP)
tamoxifen  (EXP,ISO)
taurocholic acid  (ISO)
teriflunomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetracaine  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
thiram  (ISO)
thymoquinone  (ISO)
tioguanine  (ISO)
titanium dioxide  (EXP,ISO)
tocopherol  (ISO)
toluene 2,4-diisocyanate  (EXP)
Tomentosin  (ISO)
topotecan  (ISO)
trabectedin  (EXP)
trans-pinosylvin  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
trimethylarsine oxide  (ISO)
Triptolide  (EXP)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tungsten  (EXP)
tyrphostin AG 1478  (ISO)
ursolic acid  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
vinclozolin  (EXP,ISO)
vincristine  (ISO)
vitamin E  (ISO)
vorinostat  (EXP,ISO)
wortmannin  (EXP,ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal aortic arch development  (IAGP)
abnormal bone marrow morphology  (IAGP)
abnormal cardiovascular system morphology  (IAGP)
abnormal cell morphology  (IAGP)
abnormal cell physiology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal dendritic spine morphology  (IAGP)
abnormal embryonic growth/weight/body size  (IAGP)
abnormal erythrocyte morphology  (IAGP)
abnormal erythropoiesis  (IAGP)
abnormal excitatory postsynaptic potential  (IAGP)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal fertility/fecundity  (IAGP)
abnormal intestinal epithelium morphology  (IAGP)
abnormal involution of the mammary gland  (IAGP)
abnormal myeloid leukocyte morphology  (IAGP)
abnormal placenta morphology  (IAGP)
abnormal postsynaptic density morphology  (IAGP)
abnormal reproductive system morphology  (IAGP)
abnormal spatial learning  (IAGP)
abnormal spleen red pulp morphology  (IAGP)
abnormal thrombopoiesis  (IAGP)
abnormal trophoblast giant cell morphology  (IAGP)
abnormal trophoblast layer morphology  (IAGP)
abnormal vasculogenesis  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
anemia  (IAGP)
anisopoikilocytosis  (IAGP)
atrioventricular septal defect  (IAGP)
chromosome breakage  (IAGP)
decreased embryo size  (IAGP)
decreased excitatory postsynaptic current frequency  (IAGP)
decreased fibroblast proliferation  (IAGP)
decreased tumor latency  (IAGP)
double outlet right ventricle  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
enlarged spleen  (IAGP)
extramedullary hematopoiesis  (IAGP)
increased bone marrow cell number  (IAGP)
increased erythroid progenitor cell number  (IAGP)
increased fibroblast proliferation  (IAGP)
increased mammary gland apoptosis  (IAGP)
increased mammary gland epithelial cell proliferation  (IAGP)
increased spleen weight  (IAGP)
increased splenocyte proliferation  (IAGP)
no abnormal phenotype detected  (IAGP)
ostium primum atrial septal defect  (IAGP)
premature death  (IAGP)
reduced long-term potentiation  (IAGP)
reduced male fertility  (IAGP)
reduced NMDA-mediated synaptic currents  (IAGP)
spleen hyperplasia  (IAGP)
testis hypoplasia  (IAGP)
ventricular septal defect  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Integrated profiling of basal and luminal breast cancers. Adelaide J, etal., Cancer Res. 2007 Dec 15;67(24):11565-75.
2. Overexpression of the low molecular weight cyclin E in transgenic mice induces metastatic mammary carcinomas through the disruption of the ARF-p53 pathway. Akli S, etal., Cancer Res. 2007 Aug 1;67(15):7212-22.
3. The role of cyclins and cyclins inhibitors in the multistep process of HPV-associated cervical carcinoma. Bahnassy AA, etal., J Egypt Natl Canc Inst. 2006 Dec;18(4):292-302.
4. Cyclin E confers a prognostic value in premenopausal breast cancer patients with tumours exhibiting an infiltrative growth pattern. Berglund P, etal., J Clin Pathol. 2007 May 4;.
5. Differential Effects of PI3K and Dual PI3K/mTOR Inhibition in Rat Prolactin-Secreting Pituitary Tumors. Chanal M, etal., Mol Cancer Ther. 2016 Jun;15(6):1261-70. doi: 10.1158/1535-7163.MCT-15-0891. Epub 2016 Mar 16.
6. Cell proliferation, apoptosis, and expression of cyclin D1 and cyclin E as potential biomarkers in tamoxifen-treated mammary tumors. Christov K, etal., Breast Cancer Res Treat. 2003 Feb;77(3):253-64.
7. Low-molecular weight forms of cyclin E differentiate ovarian carcinoma from cells of mesothelial origin and are associated with poor survival in ovarian carcinoma. Davidson B, etal., Cancer. 2007 Sep 15;110(6):1264-71.
8. Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer. Eder AM, etal., Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12519-24. Epub 2005 Aug 22.
9. Loss of Cyclin E1 attenuates hepatitis and hepatocarcinogenesis in a mouse model of chronic liver injury. Ehedego H, etal., Oncogene. 2018 Jun;37(25):3329-3339. doi: 10.1038/s41388-018-0181-8. Epub 2018 Mar 19.
10. Parallel cyclin E and cyclin A expression in neoplastic lesions of the uterine cervix. Erlandsson F, etal., Br J Cancer. 2006 Apr 10;94(7):1045-50.
11. Progressive derailment of cell cycle regulators in endometrial carcinogenesis. Horree N, etal., J Clin Pathol. 2008 Jan;61(1):36-42. Epub 2007 May 4.
12. Overexpression of cyclin D1 and cyclin E in 1,2-dimethylhydrazine dihydrochloride-induced rat colon carcinogenesis. Hur K, etal., J Vet Sci. 2000 Dec;1(2):121-6.
13. Effect of energy restriction on cell cycle machinery in 1-methyl-1-nitrosourea-induced mammary carcinomas in rats. Jiang W, etal., Cancer Res. 2003 Mar 15;63(6):1228-34.
14. Quantitative analysis of cyclin E and protein p34 cdc2 expression in superficial bladder cancer. Kaczmarek P, etal., Pol J Pathol. 2006;57(1):41-4.
15. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
16. Overexpression of p21, cyclin E and decreased expression of p27 in DMBA (7, 12-dimethylbenzanthracene)-induced rat ovarian carcinogenesis. Kim KK, etal., Pathol Int. 2003 May;53(5):291-6.
17. Sunitinib Inhibits Breast Cancer Cell Proliferation by Inducing Apoptosis, Cell-cycle Arrest and DNA Repair While Inhibiting NF-κB Signaling Pathways. Korashy HM, etal., Anticancer Res. 2017 Sep;37(9):4899-4909. doi: 10.21873/anticanres.11899.
18. Differential expression of cell cycle regulatory molecules and evidence for a "cyclin switch" during progression of prostate cancer. Maddison LA, etal., Prostate. 2004 Mar 1;58(4):335-44.
19. Mammalian cyclin-dependent kinases. Malumbres M and Barbacid M, Trends Biochem Sci. 2005 Nov;30(11):630-41. Epub 2005 Oct 19.
20. Cell-cycle inhibition by TNP-470 in an in vivo model of hepatocarcinoma is mediated by a p53 and p21WAF1/CIP1 mechanism. Mauriz JL, etal., Transl Res. 2007 Jan;149(1):46-53.
21. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
22. MGDs mouse GO annotations MGD data from the GO Consortium
23. MGD IEA MGD IEA
24. Cyclin E is the only cyclin-dependent kinase 2-associated cyclin that predicts metastasis and survival in early stage non-small cell lung cancer. Müller-Tidow C, etal., Cancer Res. 2001 Jan 15;61(2):647-53.
25. Elevated cyclin E level in human clear cell renal cell carcinoma: possible causes and consequences. Nauman A, etal., Acta Biochim Pol. 2007;54(3):595-602. Epub 2007 Aug 28.
26. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
27. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
28. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
29. Fraxetin inhibits the growth of colon adenocarcinoma cells via the Janus kinase 2/signal transducer and activator of transcription 3 signalling pathway. Ren S, etal., Int J Biochem Cell Biol. 2020 Aug;125:105777. doi: 10.1016/j.biocel.2020.105777. Epub 2020 Jun 3.
30. Mouse MP Annotation Import Pipeline RGD automated import pipeline
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. HPV related VIN: highly proliferative and diminished responsiveness to extracellular signals. Santegoets LA, etal., Int J Cancer. 2007 Aug 15;121(4):759-66.
33. Up-regulation of cyclin-dependent kinase 4/cyclin D2 expression but down-regulation of cyclin-dependent kinase 2/cyclin E in testicular germ cell tumors. Schmidt BA, etal., Cancer Res. 2001 May 15;61(10):4214-21.
34. The human papillomavirus E6 oncogene dysregulates the cell cycle and contributes to cervical carcinogenesis through two independent activities. Shai A, etal., Cancer Res. 2007 Feb 15;67(4):1626-35.
35. Correlation of cyclin D1 and E1 expression with bladder cancer presence, invasion, progression, and metastasis. Shariat SF, etal., Hum Pathol. 2006 Dec;37(12):1568-76. Epub 2006 Aug 10.
36. Association of cyclin D1 and E1 expression with disease progression and biomarkers in patients with nonmuscle-invasive urothelial cell carcinoma of the bladder. Shariat SF, etal., Urol Oncol. 2007 Nov-Dec;25(6):468-75.
37. The Pezcoller lecture: cancer cell cycles revisited. Sherr CJ Cancer Res. 2000 Jul 15;60(14):3689-95.
38. Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice. Shi SY, etal., J Biol Chem. 2017 Mar 3;292(9):3789-3799. doi: 10.1074/jbc.M116.752519. Epub 2017 Jan 18.
39. Enhanced sequential expression of G1/S cyclins during experimental epatocarcinogenesis and tyrosine phosphorylation. Sundarrajan M, etal., J Environ Pathol Toxicol Oncol. 2001;20(3):189-97.
40. Different cell cycle regulation of vascular smooth muscle in genetic hypertension. Tanner FC, etal., Hypertension. 2003 Aug;42(2):184-8. Epub 2003 Jul 7.
41. [Effects of cyclin dependent protein kinase inhibitor olomoucine on the microenvironment of axonal regeneration after spinal cord injury: an experiment with rats] Tian DS, etal., Zhonghua Yi Xue Za Zhi. 2006 Apr 4;86(13):901-5.
42. Growth pattern switch of renal cells and expression of cell cycle related proteins at the early stage of diabetic nephropathy. Zhang Y, etal., Biochem Biophys Res Commun. 2007 Nov 9;363(1):159-64. Epub 2007 Aug 31.
Additional References at PubMed
PMID:7739547   PMID:7797074   PMID:8003041   PMID:8033213   PMID:8226784   PMID:8552401   PMID:8640830   PMID:8668155   PMID:8674108   PMID:8769642   PMID:8812484   PMID:8822197  
PMID:8833259   PMID:8947040   PMID:9110315   PMID:9166596   PMID:9171369   PMID:9615220   PMID:9664690   PMID:9856457   PMID:10349636   PMID:10380928   PMID:10457012   PMID:10500095  
PMID:10508527   PMID:10531039   PMID:10618723   PMID:10790373   PMID:10913163   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11095619   PMID:11397011   PMID:11463388   PMID:11585773  
PMID:11687642   PMID:11850820   PMID:11919196   PMID:11981756   PMID:12124778   PMID:12429912   PMID:12477932   PMID:12729791   PMID:12852854   PMID:12884287   PMID:12941272   PMID:12970171  
PMID:12970191   PMID:12970760   PMID:12972599   PMID:14561402   PMID:14610273   PMID:14627988   PMID:14672936   PMID:14742445   PMID:14766969   PMID:15028671   PMID:15124020   PMID:15136151  
PMID:15155733   PMID:15214576   PMID:15299027   PMID:15315760   PMID:15327767   PMID:15459106   PMID:15707957   PMID:15722557   PMID:15730892   PMID:15749021   PMID:15782199   PMID:15799026  
PMID:15800025   PMID:15838514   PMID:16007079   PMID:16023597   PMID:16102793   PMID:16109376   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16627785   PMID:16919269   PMID:16954383  
PMID:17000767   PMID:17151017   PMID:17218276   PMID:17256742   PMID:17274640   PMID:17276355   PMID:17360482   PMID:17362983   PMID:17369397   PMID:17392792   PMID:17475776   PMID:17517888  
PMID:17581275   PMID:17699765   PMID:17700700   PMID:18206965   PMID:18340042   PMID:18356301   PMID:18443282   PMID:18462697   PMID:18559482   PMID:18635963   PMID:18819932   PMID:19056892  
PMID:19129496   PMID:19139274   PMID:19217425   PMID:19228596   PMID:19265663   PMID:19287388   PMID:19325126   PMID:19433082   PMID:19445941   PMID:19449303   PMID:19474320   PMID:19574535  
PMID:19590016   PMID:19592082   PMID:19644667   PMID:19706423   PMID:20150892   PMID:20215406   PMID:20392692   PMID:20450902   PMID:20506362   PMID:20530543   PMID:20660298   PMID:20737421  
PMID:20808958   PMID:20863901   PMID:20877462   PMID:20962587   PMID:20978349   PMID:21108844   PMID:21109536   PMID:21185283   PMID:21267068   PMID:21349854   PMID:21372285   PMID:21503901  
PMID:21518694   PMID:21519154   PMID:21536883   PMID:21636786   PMID:21677750   PMID:21690373   PMID:21731673   PMID:21746877   PMID:21873635   PMID:21944720   PMID:22154697   PMID:22206758  
PMID:22234186   PMID:22360968   PMID:22405651   PMID:22411628   PMID:22560297   PMID:22606329   PMID:22737085   PMID:22957921   PMID:23055394   PMID:23071090   PMID:23223288   PMID:23322385  
PMID:23469020   PMID:23479742   PMID:23680462   PMID:23787781   PMID:23873023   PMID:24143284   PMID:24184637   PMID:24192035   PMID:24380855   PMID:24586195   PMID:24632684   PMID:24661562  
PMID:24662053   PMID:24673559   PMID:24821722   PMID:24876127   PMID:24886500   PMID:24958101   PMID:24959908   PMID:25084151   PMID:25142465   PMID:25456500   PMID:25664857   PMID:25668206  
PMID:25784544   PMID:25848055   PMID:25934694   PMID:25956904   PMID:26025376   PMID:26091038   PMID:26241389   PMID:26449752   PMID:26567220   PMID:26581405   PMID:26712234   PMID:26966181  
PMID:26989177   PMID:27122033   PMID:27141870   PMID:27196371   PMID:27351100   PMID:27399331   PMID:27425595   PMID:27795297   PMID:27828963   PMID:27862528   PMID:28003426   PMID:28031476  
PMID:28192421   PMID:28323616   PMID:28325912   PMID:28340616   PMID:28527696   PMID:28768199   PMID:28793255   PMID:29339491   PMID:29453456   PMID:29689621   PMID:29950673   PMID:30150405  
PMID:30152757   PMID:30389914   PMID:30718289   PMID:30878468   PMID:30940846   PMID:31024075   PMID:31073164   PMID:31260508   PMID:31315048   PMID:31693903   PMID:31806625   PMID:31913463  
PMID:32325033   PMID:32703236   PMID:32758484   PMID:33448039   PMID:34168658   PMID:34246625   PMID:34746147   PMID:34905510   PMID:35084365   PMID:35623098   PMID:36220812   PMID:36762637  
PMID:37048108   PMID:37171286   PMID:37620309   PMID:38014633   PMID:38085152   PMID:39328932  


Genomics

Comparative Map Data
Ccne1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39737,797,409 - 37,806,915 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl737,797,409 - 37,806,959 (-)EnsemblGRCm39 Ensembl
GRCm38738,097,984 - 38,107,490 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl738,097,984 - 38,107,534 (-)EnsemblGRCm38mm10GRCm38
MGSCv37738,883,003 - 38,892,509 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36737,806,744 - 37,816,090 (-)NCBIMGSCv36mm8
Celera733,255,165 - 33,271,131 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map725.35NCBI
CCNE1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381929,811,991 - 29,824,312 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1929,811,991 - 29,824,312 (+)EnsemblGRCh38hg38GRCh38
GRCh371930,302,898 - 30,315,219 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361934,994,741 - 35,007,059 (+)NCBINCBI36Build 36hg18NCBI36
Build 341934,995,400 - 35,007,058NCBI
Celera1927,001,121 - 27,013,439 (+)NCBICelera
Cytogenetic Map19q12NCBI
HuRef1926,814,506 - 26,826,846 (+)NCBIHuRef
CHM1_11930,304,072 - 30,316,380 (+)NCBICHM1_1
T2T-CHM13v2.01932,337,722 - 32,350,035 (+)NCBIT2T-CHM13v2.0
Ccne1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8199,918,672 - 99,927,986 (-)NCBIGRCr8
mRatBN7.2190,781,947 - 90,791,188 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl190,781,949 - 90,791,101 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx196,177,587 - 96,186,820 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01104,643,512 - 104,652,745 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0197,935,949 - 97,945,186 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0194,485,830 - 94,495,112 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl194,485,832 - 94,494,980 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0195,575,136 - 95,584,387 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4190,568,189 - 90,577,426 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1190,646,304 - 90,655,502 (-)NCBI
Celera185,114,968 - 85,124,206 (-)NCBICelera
RH 3.4 Map1885.7RGD
Cytogenetic Map1q21NCBI
Ccne1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554687,803,346 - 7,814,872 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554687,803,610 - 7,814,872 (-)NCBIChiLan1.0ChiLan1.0
CCNE1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22035,791,482 - 35,803,832 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11937,788,541 - 37,800,858 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01926,739,285 - 26,751,630 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11935,497,576 - 35,509,289 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1935,496,700 - 35,510,295 (+)Ensemblpanpan1.1panPan2
CCNE1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11121,688,622 - 121,697,533 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1121,688,796 - 121,697,649 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1121,057,141 - 121,067,963 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01122,317,344 - 122,328,414 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1122,317,344 - 122,327,556 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11121,897,115 - 121,908,170 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01121,503,639 - 121,514,505 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01122,568,738 - 122,579,545 (-)NCBIUU_Cfam_GSD_1.0
Ccne1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093496,098,056 - 6,108,393 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365705,536,672 - 5,548,008 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365705,536,817 - 5,547,880 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCNE1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl639,919,624 - 39,933,363 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1639,919,541 - 39,933,224 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2635,242,127 - 35,255,298 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCNE1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1624,879,923 - 24,888,985 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660732,422,215 - 2,433,635 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccne1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247944,957,178 - 4,967,140 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247944,957,156 - 4,967,058 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ccne1
446 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:694
Count of miRNA genes:430
Interacting mature miRNAs:502
Transcripts:ENSMUST00000108023, ENSMUST00000124979, ENSMUST00000128785, ENSMUST00000130329, ENSMUST00000137097
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
1301969Lbw5_mlupus NZB x NZW 5 (mouse)Not determined72684761560851775Mouse
38501071Stsl6_mSalmonella typhimurium susceptibility locus 6 (mouse)73419942551149748Mouse
1357586Mdmsc3_mmodifier of muscularity 3 (mouse)Not determined73444786968448018Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
39128210Lwq19_mliver weight QTL 19 (mouse)73349772758148965Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
1357469Kidq5_mkidney weight QTL 5 (mouse)Not determined73349772758148965Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
4142003W3q10_mweight 3 weeks QTL 10 (mouse)Not determined3349772758148965Mouse
12790989Tgl6_mtriglyceride 6 (mouse)72754054961540549Mouse
1559000Ossc1_mosteosarcoma susceptibility 1 (mouse)Not determined73405302568053223Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
4141805Sle19_msystematic lupus erythematosus susceptibility 19 (mouse)Not determined3003248581135653Mouse
1357634Splq7_mspleen weight QTL 7 (mouse)Not determined73349772758148965Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined7998886743988984Mouse
1300996Aorls2_maortic lesion size 2 (mouse)Not determined73239453266394681Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
1301514Rigs1_mradiation induced gastroschisis 1 (mouse)Not determined73628001592394346Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
1301041Prnr2_mprion resistance 2 (mouse)Not determined71872879439674033Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1301175Ap7q_malcohol preference 7 QTL (mouse)Not determined73171484565715077Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse
4142102Tailq5_mtail length QTL 5 (mouse)Not determined3349772758148965Mouse
4141909W10q18_mweight 10 weeks QTL 18 (mouse)Not determined3349772758148965Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
1357883Epfq5_mepididymal fat pad weight QTL 5 (mouse)Not determined73349772758148965Mouse
10045622Heal20_mwound healing/regeneration 20 (mouse)Not determined73431688768317043Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
4142218W6q17_mweight 6 weeks QTL 17 (mouse)Not determined3349772758148965Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71030579844305936Mouse
25314303Vmm4_mvariable multisystem mineralization 4, kidney (mouse)73729942587049208Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse
25314301Vmm3_mvariable multisystem mineralization 3, lung (mouse)73729942572049748Mouse

Markers in Region
AW538188  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38738,098,281 - 38,098,421UniSTSGRCm38
MGSCv37738,883,300 - 38,883,440UniSTSGRCm37
Celera733,255,462 - 33,255,602UniSTS
Cytogenetic Map7B2UniSTS
cM Map716.0UniSTS
UniSTS:235654  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38738,098,134 - 38,098,219UniSTSGRCm38
MGSCv37738,883,153 - 38,883,238UniSTSGRCm37
Celera733,255,315 - 33,255,400UniSTS
Cytogenetic Map7B2UniSTS
cM Map716.0UniSTS
Ccne1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7B2UniSTS
cM Map725.35UniSTS
Ccne1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7B2UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000108023   ⟹   ENSMUSP00000103658
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl737,797,409 - 37,806,959 (-)Ensembl
GRCm38.p6 Ensembl738,097,984 - 38,107,534 (-)Ensembl
Ensembl Acc Id: ENSMUST00000124979   ⟹   ENSMUSP00000145532
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl737,802,593 - 37,806,927 (-)Ensembl
GRCm38.p6 Ensembl738,103,168 - 38,107,502 (-)Ensembl
Ensembl Acc Id: ENSMUST00000128785
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl737,798,093 - 37,798,926 (-)Ensembl
GRCm38.p6 Ensembl738,098,668 - 38,099,501 (-)Ensembl
Ensembl Acc Id: ENSMUST00000130329   ⟹   ENSMUSP00000117662
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl737,800,083 - 37,806,333 (-)Ensembl
GRCm38.p6 Ensembl738,100,658 - 38,106,908 (-)Ensembl
Ensembl Acc Id: ENSMUST00000137097
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl737,798,236 - 37,798,794 (-)Ensembl
GRCm38.p6 Ensembl738,098,811 - 38,099,369 (-)Ensembl
RefSeq Acc Id: NM_007633   ⟹   NP_031659
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39737,797,409 - 37,806,915 (-)NCBI
GRCm38738,097,984 - 38,107,490 (-)ENTREZGENE
MGSCv37738,883,003 - 38,892,509 (-)RGD
Celera733,255,165 - 33,271,131 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_031659   ⟸   NM_007633
- UniProtKB: Q05BA6 (UniProtKB/Swiss-Prot),   Q05BA1 (UniProtKB/Swiss-Prot),   Q05BB7 (UniProtKB/Swiss-Prot),   Q61457 (UniProtKB/Swiss-Prot),   B2RS11 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000117662   ⟸   ENSMUST00000130329
Ensembl Acc Id: ENSMUSP00000145532   ⟸   ENSMUST00000124979
Ensembl Acc Id: ENSMUSP00000103658   ⟸   ENSMUST00000108023
Protein Domains
Cyclin C-terminal   Cyclin N-terminal   Cyclin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61457-F1-model_v2 AlphaFold Q61457 1-408 view protein structure

Promoters
RGD ID:8663695
Promoter ID:EPDNEW_M9879
Type:initiation region
Name:Ccne1_1
Description:Mus musculus cyclin E1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38738,107,477 - 38,107,537EPDNEW
RGD ID:6840800
Promoter ID:MM_KWN:50066
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Lung,   Spleen
Transcripts:ENSMUST00000051596,   OTTMUST00000053001,   OTTMUST00000053002,   OTTMUST00000053003
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36738,892,161 - 38,893,272 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88316 AgrOrtholog
Ensembl Genes ENSMUSG00000002068 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000108023 ENTREZGENE
  ENSMUST00000108023.10 UniProtKB/Swiss-Prot
  ENSMUST00000124979.3 UniProtKB/TrEMBL
  ENSMUST00000130329.2 UniProtKB/TrEMBL
Gene3D-CATH Cyclin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyclin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_C-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclins_cyclin-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12447 UniProtKB/Swiss-Prot
MGD MGI:88316 ENTREZGENE
NCBI Gene 12447 ENTREZGENE
PANTHER PTHR10177 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10177:SF71 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cyclin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ccne1 PhenoGen
PROSITE CYCLINS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CYCLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47954 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0U1RNE6_MOUSE UniProtKB/TrEMBL
  A0JLN2_MOUSE UniProtKB/TrEMBL
  B2RS11 ENTREZGENE, UniProtKB/TrEMBL
  CCNE1_MOUSE UniProtKB/Swiss-Prot
  D3Z3N8_MOUSE UniProtKB/TrEMBL
  Q05BA1 ENTREZGENE
  Q05BA6 ENTREZGENE
  Q05BB7 ENTREZGENE
  Q61457 ENTREZGENE
UniProt Secondary Q05BA1 UniProtKB/Swiss-Prot
  Q05BA6 UniProtKB/Swiss-Prot
  Q05BB7 UniProtKB/Swiss-Prot