G6PD (glucose-6-phosphate dehydrogenase) - Rat Genome Database

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Gene: G6PD (glucose-6-phosphate dehydrogenase) Homo sapiens
Analyze
Symbol: G6PD
Name: glucose-6-phosphate dehydrogenase
RGD ID: 736474
HGNC Page HGNC:4057
Description: Enables several functions, including D-glucose binding activity; glucose-6-phosphate dehydrogenase activity; and protein homodimerization activity. Involved in several processes, including erythrocyte maturation; negative regulation of protein glutathionylation; and pentose-phosphate shunt, oxidative branch. Located in several cellular components, including centriolar satellite; cytoplasmic side of plasma membrane; and cytosol. Implicated in several diseases, including anemia (multiple); cerebrovascular disease; favism; malaria (multiple); and neonatal jaundice. Biomarker of hepatocellular carcinoma; type 1 diabetes mellitus; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CNSHA1; G6PD1; glucose-6-phosphate 1-dehydrogenase; glucose-6-phosphate dehydrogenase, G6PD
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X154,531,390 - 154,547,569 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX154,517,825 - 154,547,572 (-)EnsemblGRCh38hg38GRCh38
GRCh37X153,759,605 - 153,775,784 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X153,412,800 - 153,428,981 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X153,323,309 - 153,339,173NCBI
CeleraX153,920,654 - 153,936,836 (-)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX142,336,102 - 142,352,295 (-)NCBIHuRef
CHM1_1X153,671,375 - 153,687,556 (-)NCBICHM1_1
T2T-CHM13v2.0X152,767,773 - 152,783,952 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (EXP)
adrenoleukodystrophy  (IAGP)
ALAD-Deficiency Porphyria  (ISO)
anemia  (IAGP,IDA)
autistic disorder  (IAGP)
autosomal hemophilia A  (IAGP)
Barth syndrome  (IAGP)
Brain Injuries  (ISO)
cataract  (ISO)
cerebral creatine deficiency syndrome 1  (IAGP)
cerebrovascular disease  (IDA)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
chronic granulomatous disease  (EXP)
congenital hemolytic anemia  (IAGP)
congenital hypothyroidism  (ISO)
congenital nonspherocytic hemolytic anemia  (EXP,IAGP)
contact dermatitis  (EXP)
Coronary Disease  (IAGP)
diabetes mellitus  (IDA)
Diabetic Nephropathies  (ISO)
dyskeratosis congenita  (IAGP)
ectodermal dysplasia and immune deficiency  (IAGP)
ectodermal dysplasia and immunodeficiency 1  (IAGP)
Emery-Dreifuss muscular dystrophy  (IAGP)
Experimental Diabetes Mellitus  (ISO)
factor VIII deficiency  (IAGP)
favism  (EXP,IAGP,ISS)
Fever  (IAGP)
genetic disease  (IAGP)
glucosephosphate dehydrogenase deficiency  (EXP,IAGP)
Hemolysis  (EXP,IAGP)
hemolytic anemia  (EXP,IAGP)
hepatic encephalopathy  (ISO)
hepatocellular carcinoma  (IEP,ISO)
Hypercholesterolemia  (ISO)
hyperhomocysteinemia  (ISO)
Hypertriglyceridemia  (ISO)
immunodeficiency 33  (IAGP)
Insulin Resistance  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (ISO)
Liver Injury  (ISO)
malaria  (EXP,IAGP)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
metachromatic leukodystrophy  (IAGP)
Multi-Infarct Dementia  (ISO)
myocardial infarction  (ISO)
Neonatal Hyperbilirubinemia  (IDA)
neonatal jaundice  (IAGP)
obesity  (ISO)
paraplegia  (IAGP)
periventricular nodular heterotopia  (IAGP)
phagocyte bactericidal dysfunction  (EXP)
phenylketonuria  (ISO)
Plasmodium falciparum malaria  (IAGP)
Pulmonary Hypertension, Hypoxia-Induced  (ISO)
renovascular hypertension  (ISO)
severe congenital encephalopathy due to MECP2 mutation  (IAGP)
Splenomegaly  (IAGP)
syndromic X-linked intellectual disability Lubs type  (IAGP)
Testicular Injury  (ISO)
transient cerebral ischemia  (ISO)
type 1 diabetes mellitus  (IEP)
type 2 diabetes mellitus  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (EXP)
(+)-schisandrin B  (ISO)
(+)-taxifolin  (ISO)
(E)-cinnamyl alcohol  (EXP)
(R)-noradrenaline  (ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-methylphenanthrene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (EXP)
2,4-dinitrotoluene  (ISO)
2,5-dihydroxybenzoic acid  (EXP,ISO)
2-(4-hydroxyphenyl)ethanol  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-hydroxypropanoic acid  (EXP)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-dihydroxybenzaldehyde  (EXP)
3,4-dihydroxybenzoic acid  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-methylglutaric acid  (ISO)
3-phenylprop-2-enal  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-amino-2,6-dinitrotoluene  (ISO)
4-chlorobiphenyl  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-formyltetrahydrofolic acid  (ISO)
5-methylphenazinium methyl sulfate  (EXP)
9-cis-retinoic acid  (EXP)
acetaldehyde  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (EXP)
actinomycin D  (EXP,ISO)
aflatoxin B1  (EXP)
albuterol  (ISO)
all-trans-4-oxoretinoic acid  (EXP)
all-trans-retinoic acid  (EXP)
alpha-hexylcinnamaldehyde  (EXP)
aluminium atom  (EXP,ISO)
aluminium phosphide  (ISO)
aluminium(0)  (EXP,ISO)
amiodarone  (EXP,ISO)
ammonium chloride  (ISO)
amosite asbestos  (EXP)
androsterone  (ISO)
antimycin A  (EXP)
aristolochic acid A  (EXP)
arjunolic acid  (ISO)
Aroclor 1254  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP,ISO)
astaxanthin  (ISO)
atenolol  (ISO)
atrazine  (ISO)
Augmentin  (EXP)
azoxystrobin  (EXP)
Bandrowski's base  (EXP)
benzatropine  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
Benzo[k]fluoranthene  (ISO)
benzoic acid  (EXP)
Benzoyl peroxide  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (ISO)
biochanin A  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP)
bortezomib  (EXP)
bromobenzene  (ISO)
buspirone  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium nitrate  (ISO)
caffeine  (EXP)
calcitriol  (EXP)
Calphostin C  (ISO)
cannabidiol  (EXP)
carbaryl  (ISO)
carbon nanotube  (ISO)
carnosine  (EXP)
cefaloridine  (ISO)
chelerythrine  (ISO)
chlorite  (EXP)
chloroprene  (ISO)
chlorpromazine  (EXP,ISO)
chlorpyrifos  (ISO)
cinnamyl alcohol  (EXP)
ciprofloxacin  (EXP)
cis-caffeic acid  (EXP)
cisplatin  (EXP,ISO)
citronellol  (ISO)
clavulanic acid  (EXP)
clozapine  (EXP)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
coenzyme Q10  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (EXP)
crocidolite asbestos  (EXP)
cumene hydroperoxide  (ISO)
curcumin  (EXP,ISO)
cycloartenol  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
dapsone  (EXP)
DDT  (ISO)
decabromodiphenyl ether  (EXP)
deguelin  (EXP)
dehydroepiandrosterone  (ISO)
dexamethasone  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
Diallyltetrasulfane  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (EXP)
dibenzo[a,l]pyrene  (EXP)
dichloroacetic acid  (ISO)
dicyclanil  (ISO)
dieldrin  (ISO)
diethyl malate  (EXP)
diethyl maleate  (EXP,ISO)
digoxin  (ISO)
dihydroartemisinin  (EXP)
dimethoate  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP)
diquat  (EXP,ISO)
disulfiram  (EXP)
diuron  (ISO)
dobutamine  (ISO)
dopamine  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
ellagic acid  (EXP)
endosulfan  (ISO)
enzyme inhibitor  (EXP)
etomoxir  (ISO)
eugenol  (EXP)
fenoterol  (ISO)
fenpyroximate  (EXP)
fenvalerate  (ISO)
ferulic acid  (EXP)
fluoranthene  (EXP)
flutamide  (ISO)
fluvastatin  (ISO)
folic acid  (ISO)
fructose  (ISO)
fulvestrant  (EXP,ISO)
furan  (ISO)
furosemide  (ISO)
gallic acid  (ISO)
Gallopamil  (ISO)
gamma-hexachlorocyclohexane  (ISO)
Ganoderic acid A  (ISO)
genistein 7-O-beta-D-glucoside  (EXP)
gentamycin  (ISO)
geraniol  (ISO)
glafenine  (ISO)
gliclazide  (ISO)
glutaraldehyde  (EXP)
glutathione  (EXP,ISO)
Glutathione ethyl ester  (ISO)
glyburide  (ISO)
glycidyl methacrylate  (EXP)
glyoxylic acid  (ISO)
glyphosate  (ISO)
herbacetin  (ISO)
herbicide  (ISO)
hesperetin  (ISO)
hesperidin  (EXP,ISO)
Hexachloro-1,3-butadiene  (ISO)
hexane  (EXP)
hydrogen peroxide  (EXP,ISO)
hypochlorous acid  (EXP)
indometacin  (ISO)
inositol  (ISO)
iron trichloride  (ISO)
iron(III) nitrilotriacetate  (ISO)
isoeugenol  (EXP)
isoflavones  (EXP)
isoniazide  (EXP)
isoprenaline  (ISO)
isosorbide dinitrate  (EXP)
isotretinoin  (EXP,ISO)
ivermectin  (EXP)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-glutamine  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
lovastatin  (ISO)
malathion  (ISO)
maneb  (ISO)
melatonin  (EXP,ISO)
mercury atom  (EXP)
mercury dichloride  (ISO)
mercury(0)  (EXP)
metformin  (ISO)
methapyrilene  (ISO)
methotrexate  (EXP,ISO)
methoxychlor  (ISO)
methyl salicylate  (EXP)
methylene blue  (EXP)
methylmercury chloride  (EXP)
metoprolol  (ISO)
monocrotophos  (ISO)
monosodium L-glutamate  (ISO)
myo-inositol hexakisphosphate  (ISO)
myricetin  (ISO)
N,N'-diphenyl-1,4-phenylenediamine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (ISO)
NADP zwitterion  (EXP,ISO)
NADP(+)  (EXP,ISO)
naringin  (ISO)
nerolidol  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (EXP,ISO)
nicotinamide  (ISO)
nicotine  (ISO)
nitroprusside  (EXP,ISO)
Nonylphenol  (ISO)
norfenefrine  (ISO)
Nutlin-3  (EXP)
ochratoxin A  (EXP)
p-toluidine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
potassium bromate  (ISO)
potassium chromate  (EXP,ISO)
potassium dichromate  (EXP,ISO)
prazosin  (ISO)
primaquine  (EXP)
promethazine  (ISO)
propan-2-ol  (EXP)
propetamphos  (ISO)
pyrroles  (EXP)
quartz  (ISO)
quercetin  (EXP,ISO)
quinalphos  (ISO)
quinolinic acid  (ISO)
rac-lactic acid  (EXP)
Rebamipide  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (EXP)
senecionine  (ISO)
serpentine asbestos  (EXP,ISO)
silibinin  (ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
sinapic acid  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium chlorate  (ISO)
sodium dodecyl sulfate  (EXP)
sodium fluoride  (ISO)
sodium nitrate  (ISO)
sodium nitrite  (EXP)
streptozocin  (ISO)
sulforaphane  (EXP)
sunitinib  (EXP)
T-2 toxin  (ISO)
tadalafil  (ISO)
tamoxifen  (EXP,ISO)
taurine  (ISO)
terbutaline  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thimerosal  (EXP)
thioacetamide  (ISO)
thiram  (EXP)
thymoquinone  (ISO)
titanium dioxide  (EXP,ISO)
trans-caffeic acid  (EXP)
trans-isoeugenol  (EXP)
trans-piceid  (EXP)
trichloroethene  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
valproic acid  (EXP,ISO)
vanillin  (EXP)
vinclozolin  (ISO)
vitamin E  (ISO)
vorinostat  (EXP)
zearalenone  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc nitrate  (ISO)
zinc sulfate  (EXP)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Protective effect of Satureja montana extract on cyclophosphamide-induced testicular injury in rats. Abd El Tawab AM, etal., Chem Biol Interact. 2014 Nov 11;224C:196-205. doi: 10.1016/j.cbi.2014.11.001.
2. Cardioprotective effects of aqueous extract of Oxalis corniculata in experimental myocardial infarction. Abhilash PA, etal., Exp Toxicol Pathol. 2011 Sep;63(6):535-40. doi: 10.1016/j.etp.2010.04.004. Epub 2010 May 11.
3. Oxidative stress and modification of synaptic proteins in hippocampus after traumatic brain injury. Ansari MA, etal., Free Radic Biol Med. 2008 Aug 15;45(4):443-52. Epub 2008 May 3.
4. Association of candidate gene polymorphisms and TGF-beta/IL-10 levels with malaria in three regions of Cameroon: a case-control study. Apinjoh TO, etal., Malar J. 2014 Jun 16;13:236. doi: 10.1186/1475-2875-13-236.
5. Hyperbaric oxygen preconditioning protects rats against CNS oxygen toxicity. Arieli Y, etal., Respir Physiol Neurobiol. 2014 Jun 15;197:29-35. doi: 10.1016/j.resp.2014.03.006. Epub 2014 Mar 24.
6. Adequate hemodialysis improves anemia by enhancing glucose-6-phosphate dehydrogenase activity in patients with end-stage renal disease. Ayesh Haj Yousef MH, etal., BMC Nephrol. 2014 Sep 26;15:155. doi: 10.1186/1471-2369-15-155.
7. DNA sequence abnormalities of human glucose-6-phosphate dehydrogenase variants. Beutler E, etal., J Biol Chem. 1991 Mar 5;266(7):4145-50.
8. The cellular fate of glucose and its relevance in type 2 diabetes. Bouche C, etal., E