Arg1 (arginase, liver) - Rat Genome Database

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Gene: Arg1 (arginase, liver) Mus musculus
Analyze
Symbol: Arg1
Name: arginase, liver
RGD ID: 736430
MGI Page MGI
Description: Enables arginase activity. Involved in defense response to protozoan; negative regulation of T-helper 2 cell cytokine production; and negative regulation of activated T cell proliferation. Acts upstream of or within response to nematode. Predicted to be located in extracellular space; mitochondrial outer membrane; and neuronal cell body. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study hyperargininemia. Human ortholog(s) of this gene implicated in asthma; hepatocellular carcinoma; and hyperargininemia. Orthologous to human ARG1 (arginase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI; AI256583; Arg; Arg-1; arginase 1, liver; arginase I; arginase-1; liver-type arginase; PG; PGIF; type I arginase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391024,791,105 - 24,803,368 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1024,791,119 - 24,803,382 (-)EnsemblGRCm39 Ensembl
GRCm381024,915,207 - 24,927,470 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1024,915,221 - 24,927,484 (-)EnsemblGRCm38mm10GRCm38
MGSCv371024,635,013 - 24,647,276 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361024,604,637 - 24,617,896 (-)NCBIMGSCv36mm8
Celera1025,846,180 - 25,858,528 (-)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1012.26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(E)-thiamethoxam  (ISO)
(S)-colchicine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1-bromopropane  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrabromodibenzodioxine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,5-hexanedione  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aminoimidazole-4-carboxamide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acetamide  (ISO)
acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
agathisflavone  (ISO)
AICA ribonucleotide  (ISO)
all-trans-retinoic acid  (EXP,ISO)
AM6545  (EXP)
amiodarone  (ISO)
amitriptyline  (ISO)
amlexanox  (EXP)
ammonium chloride  (ISO)
ampicillin  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (EXP)
astaxanthin  (EXP)
azithromycin  (EXP)
azoxystrobin  (ISO)
Bardoxolone methyl  (EXP)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-amyrin  (EXP)
bexarotene  (ISO)
bicalutamide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (EXP)
boric acid  (ISO)
bromobenzene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calciol  (ISO)
calcitriol  (ISO)
cannabidiol  (EXP)
carbendazim  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (EXP)
cis-caffeic acid  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (EXP)
cortisol  (ISO)
coumarin  (ISO)
crocidolite asbestos  (EXP)
Cyclopamine  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (EXP)
cyproconazole  (ISO)
cyprodinil  (ISO)
DDE  (EXP)
decabromodiphenyl ether  (ISO)
dextran sulfate  (EXP)
Diallyl sulfide  (ISO)
diarsenic trioxide  (EXP)
diazinon  (ISO)
dibenzofurans  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
difenoconazole  (ISO)
dimethomorph  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (EXP)
diuron  (ISO)
donepezil hydrochloride  (EXP)
dopamine  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP)
elemental selenium  (EXP)
endosulfan  (ISO)
enilconazole  (ISO)
epoxiconazole  (ISO)
ethoprophos  (ISO)
excitatory amino acid agonist  (ISO)
fasudil  (ISO)
fenhexamid  (ISO)
fenpyroximate  (ISO)
fipronil  (ISO)
flavonoids  (ISO)
fludioxonil  (ISO)
flurbiprofen  (EXP)
flusilazole  (ISO)
flutamide  (ISO)
fluxapyroxad  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
fulvestrant  (EXP)
furan  (ISO)
genistein  (EXP)
gentamycin  (ISO)
glyburide  (EXP,ISO)
glycidol  (ISO)
graphene oxide  (EXP)
graphite  (ISO)
hexadecanoic acid  (EXP,ISO)
HU-308  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
imipramine  (EXP)
indometacin  (ISO)
iodide salt  (ISO)
isoliquiritigenin  (EXP)
ketoconazole  (ISO)
L-ethionine  (ISO)
L-methionine  (EXP,ISO)
Lasiocarpine  (ISO)
leflunomide  (EXP)
limonene  (ISO)
linuron  (EXP)
lipopolysaccharide  (EXP,ISO)
maneb  (EXP,ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mechlorethamine  (ISO)
MeIQx  (ISO)
melatonin  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metformin  (EXP,ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
mifepristone  (ISO)
Morroniside  (EXP)
N,N-dimethylformamide  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (ISO)
naphthalene  (EXP)
nefazodone  (ISO)
nickel dichloride  (ISO)
nitrofen  (ISO)
NS-398  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
oleic acid  (ISO)
omeprazole  (ISO)
ozone  (EXP,ISO)
paeoniflorin  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP)
pirinixic acid  (EXP,ISO)
potassium bromate  (ISO)
PRIM-O-GLUCOSYLCIMIFUGIN  (EXP)
prochloraz  (ISO)
progesterone  (EXP)
propiconazole  (EXP,ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (EXP)
rotenone  (EXP,ISO)
salicylic acid  (ISO)
SB 203580  (EXP)
selenium atom  (EXP)
sevoflurane  (EXP)
sildenafil citrate  (EXP)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
Sinomenine  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
streptozocin  (EXP,ISO)
sunitinib  (EXP)
tamoxifen  (EXP)
tauroursodeoxycholic acid  (ISO)
tebuconazole  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thiamethoxam  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
trans-caffeic acid  (EXP)
tremolite asbestos  (EXP)
triadimefon  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
trypanothione  (ISO)
trypanothione disulfide  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
ursolic acid  (EXP)
valproic acid  (EXP,ISO)
WIN 55212-2  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IEA)
arginine catabolic process to ornithine  (IBA,ISO)
arginine metabolic process  (IEA,ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to glucagon stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to interleukin-4  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
collagen biosynthetic process  (ISO)
defense response to protozoan  (IMP)
female pregnancy  (ISO)
innate immune response  (IEA)
liver development  (ISO)
lung development  (ISO)
mammary gland involution  (ISO)
maternal process involved in female pregnancy  (ISO)
negative regulation of activated T cell proliferation  (IMP)
negative regulation of T cell proliferation  (ISO)
negative regulation of T-helper 2 cell cytokine production  (IMP)
negative regulation of type II interferon-mediated signaling pathway  (IEA,ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of neutrophil mediated killing of fungus  (IEA,ISO)
regulation of L-arginine import across plasma membrane  (ISO)
response to amine  (ISO)
response to amino acid  (ISO)
response to axon injury  (ISO)
response to cadmium ion  (ISO)
response to herbicide  (ISO)
response to lipopolysaccharide  (ISO)
response to manganese ion  (ISO)
response to methylmercury  (ISO)
response to nematode  (IDA)
response to peptide hormone  (ISO)
response to selenium ion  (ISO)
response to steroid hormone  (ISO)
response to vitamin A  (ISO)
response to vitamin E  (ISO)
response to xenobiotic stimulus  (ISO)
response to zinc ion  (ISO)
urea cycle  (IEA,ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Treatment with the arginase inhibitor N(omega)-hydroxy-nor-L-arginine improves vascular function and lowers blood pressure in adult spontaneously hypertensive rat. Bagnost T, etal., J Hypertens. 2008 Jun;26(6):1110-8.
2. Decreased urea synthesis in cafeteria-diet-induced obesity in the rat. Barber T, etal., Biochem J. 1985 Sep 15;230(3):675-81.
3. The activity of ornithine transcarbamoylase and arginase during mechanical jaundice in the rat model. Beck B, etal., J Surg Res. 2005 Jun 1;126(1):19-26.
4. Chronic hypercapnia downregulates arginase expression and activity and increases pulmonary arterial smooth muscle relaxation in the newborn rat. Belik J, etal., Am J Physiol Lung Cell Mol Physiol. 2009 Oct;297(4):L777-84. Epub 2009 Aug 7.
5. Inhibition of arginase activity ameliorates L-arginine-induced acute pancreatitis in rats. Biczo G, etal., Pancreas. 2010 Aug;39(6):868-74.
6. Significant Down-Regulation of Urea Cycle Generates Clinically Relevant Proteomic Signature in Hepatocellular Carcinoma Patients with Macrovascular Invasion. Cao Y, etal., J Proteome Res. 2019 May 3;18(5):2032-2044. doi: 10.1021/acs.jproteome.8b00921. Epub 2019 Mar 29.
7. Pegylated recombinant human arginase (rhArg-peg5,000mw) inhibits the in vitro and in vivo proliferation of human hepatocellular carcinoma through arginine depletion. Cheng PN, etal., Cancer Res. 2007 Jan 1;67(1):309-17.
8. Time course of vascular arginase expression and activity in spontaneously hypertensive rats. Demougeot C, etal., Life Sci. 2007 Feb 27;80(12):1128-34. Epub 2006 Dec 14.
9. Arginase upregulation and eNOS uncoupling contribute to impaired endothelium-dependent vasodilation in a rat model of intrauterine growth restriction. Grandvuillemin I, etal., Am J Physiol Regul Integr Comp Physiol. 2018 Sep 1;315(3):R509-R520. doi: 10.1152/ajpregu.00354.2017. Epub 2018 May 9.
10. Cloning and characterization of the mouse and rat type II arginase genes. Iyer RK, etal., Mol Genet Metab 1998 Mar;63(3):168-75.
11. Middle East Respiratory Syndrome-Coronavirus Infection into Established hDPP4-Transgenic Mice Accelerates Lung Damage Via Activation of the Pro-Inflammatory Response and Pulmonary Fibrosis. Kim J, etal., J Microbiol Biotechnol. 2020 Mar 28;30(3):427-438. doi: 10.4014/jmb.1910.10055.
12. Coinduction of nitric oxide synthase and arginine metabolic enzymes in endotoxin-induced uveitis rats. Koga T, etal., Exp Eye Res 2002 Dec;75(6):659-67.
13. Genetic polymorphisms in arginase I and II and childhood asthma and atopy. Li H, etal., J Allergy Clin Immunol. 2006 Jan;117(1):119-26. Epub 2005 Nov 28.
14. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
15. MGDs mouse GO annotations MGD data from the GO Consortium
16. MGD IEA MGD IEA
17. Advantage of serum type-I arginase and ornithine carbamoyltransferase in the evaluation of acute and chronic liver damage induced by thioacetamide in rats. Murayama H, etal., Clin Chim Acta. 2007 Jan;375(1-2):63-8. Epub 2006 Jun 21.
18. Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos. Neidhardt L, etal., Mech Dev 2000 Nov;98(1-2):77-94.
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
23. Cell- and isoform-specific increases in arginase expression in acute silica-induced pulmonary inflammation. Poljakovic M, etal., J Toxicol Environ Health A. 2007 Jan 15;70(2):118-27.
24. Insulin resistance induced by a high-fructose diet potentiates thioacetamide hepatotoxicity. Pooranaperundevi M, etal., Singapore Med J. 2010 May;51(5):389-98.
25. Induction of arginase isoforms in the lung during hyperoxia. Que LG, etal., Am J Physiol. 1998 Jul;275(1 Pt 1):L96-102.
26. Liver I/R injury is improved by the arginase inhibitor, N(omega)-hydroxy-nor-L-arginine (nor-NOHA). Reid KM, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Feb;292(2):G512-7. Epub 2006 Oct 5.
27. Mouse MP Annotation Import Pipeline RGD automated import pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Diabetes-induced coronary vascular dysfunction involves increased arginase activity. Romero MJ, etal., Circ Res. 2008 Jan 4;102(1):95-102. Epub 2007 Oct 25.
31. Arginine transport is augmented, through modulation of cationic amino acid transporter-1, in obstructive uropathy in rats. Schwartz IF, etal., Kidney Blood Press Res. 2008;31(3):210-6. Epub 2008 Jun 14.
32. L-Arginine transport is augmented through up-regulation of tubular CAT-2 mRNA in ischemic acute renal failure in rats. Schwartz IF, etal., Kidney Int 2002 Nov;62(5):1700-6.
33. IL-33-induced alternatively activated macrophage attenuates the development of TNBS-induced colitis. Tu L, etal., Oncotarget. 2017 Apr 25;8(17):27704-27714. doi: 10.18632/oncotarget.15984.
34. Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models. Tygstrup N, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):518-25.
35. Molecular basis of phenotypic variation in patients with argininemia. Uchino T, etal., Hum Genet. 1995 Sep;96(3):255-60.
36. Arginase 1 and arginase 2 variations associate with asthma, asthma severity and beta2 agonist and steroid response. Vonk JM, etal., Pharmacogenet Genomics. 2010 Mar;20(3):179-86.
37. Induction of arginase II in livers of bile duct-ligated rats. Wei CL, etal., Biochem Pharmacol. 2002 Mar 15;63(6):1043-50.
38. Arginase acts as an alternative pathway of L-arginine metabolism in experimental colon anastomosis. Witte MB, etal., J Gastrointest Surg. 2003 Mar-Apr;7(3):378-85.
39. Upregulation of arginase expression in wound-derived fibroblasts. Witte MB, etal., J Surg Res 2002 Jun 1;105(1):35-42.
40. Role of KCa3.1 Channels in Macrophage Polarization and Its Relevance in Atherosclerotic Plaque Instability. Xu R, etal., Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):226-236. doi: 10.1161/ATVBAHA.116.308461. Epub 2016 Dec 29.
41. The heterogeneous distribution of argininosuccinate synthetase in the liver of type II citrullinemic patients. Its specificity and possible clinical implications. Yagi Y, etal., Am J Clin Pathol. 1988 Jun;89(6):735-41.
42. Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. Zimmermann N, etal., J Clin Invest. 2003 Jun;111(12):1863-74.
Additional References at PubMed
PMID:3039990   PMID:9060991   PMID:9502196   PMID:9887201   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11278703   PMID:11714822   PMID:11982856   PMID:12011984  
PMID:12049781   PMID:12052859   PMID:12081826   PMID:12466851   PMID:12477932   PMID:12496409   PMID:12679322   PMID:14675208   PMID:14681479   PMID:15128819   PMID:15187136   PMID:15265947  
PMID:15489334   PMID:15665733   PMID:15922518   PMID:16113329   PMID:16141072   PMID:16141073   PMID:16186186   PMID:16455964   PMID:16602821   PMID:16753325   PMID:16773651   PMID:16794538  
PMID:17015747   PMID:17101732   PMID:17218616   PMID:17442735   PMID:17450126   PMID:17577214   PMID:17683524   PMID:17686999   PMID:17933574   PMID:17997338   PMID:18323470   PMID:18473687  
PMID:18478052   PMID:18554416   PMID:18824264   PMID:18828017   PMID:18973680   PMID:18978793   PMID:19027033   PMID:19286931   PMID:19360123   PMID:19414774   PMID:19561100   PMID:19590038  
PMID:19713467   PMID:20084116   PMID:20091314   PMID:20483789   PMID:20716764   PMID:20939024   PMID:21267068   PMID:21291525   PMID:21413004   PMID:21436399   PMID:21565611   PMID:21664694  
PMID:21757649   PMID:21805470   PMID:21810604   PMID:21873635   PMID:21931552   PMID:21977998   PMID:22058149   PMID:22083526   PMID:22195744   PMID:22416259   PMID:22582175   PMID:22709928  
PMID:22891289   PMID:22972923   PMID:23215832   PMID:23223430   PMID:23232640   PMID:23322377   PMID:23390893   PMID:23420878   PMID:23552798   PMID:23582327   PMID:23637937   PMID:23798541  
PMID:23831616   PMID:23913966   PMID:23920045   PMID:23924659   PMID:23977269   PMID:23977372   PMID:23991225   PMID:24190658   PMID:24204274   PMID:24224027   PMID:24244174   PMID:24324751  
PMID:24465919   PMID:24550112   PMID:24614600   PMID:24631157   PMID:24732401   PMID:24790153   PMID:24889202   PMID:24992164   PMID:25015834   PMID:25043024   PMID:25124254   PMID:25201986  
PMID:25205225   PMID:25211233   PMID:25332236   PMID:25375125   PMID:25501629   PMID:25612247   PMID:25713087   PMID:25720383   PMID:25789453   PMID:25807386   PMID:25938595   PMID:25966956  
PMID:26258883   PMID:26311113   PMID:26358260   PMID:26358771   PMID:26363032   PMID:26365184   PMID:26438688   PMID:26475291   PMID:26491691   PMID:26538310   PMID:26538654   PMID:26571397  
PMID:26644468   PMID:26675736   PMID:26704078   PMID:26743624   PMID:26777404   PMID:26932672   PMID:26952749   PMID:26974334   PMID:27043409   PMID:27088858   PMID:27117406   PMID:27166374  
PMID:27211851   PMID:27233965   PMID:27273006   PMID:27318131   PMID:27335400   PMID:27432976   PMID:27622331   PMID:27626662   PMID:27659424   PMID:27749840   PMID:27936099   PMID:27998825  
PMID:28011865   PMID:28096401   PMID:28153047   PMID:28214225   PMID:28228256   PMID:28298526   PMID:28348107   PMID:28378742   PMID:28446459   PMID:28506464   PMID:28566761   PMID:28580280  
PMID:28637295   PMID:28747341   PMID:28835451   PMID:29048462   PMID:29049022   PMID:29098611   PMID:29110610   PMID:29183288   PMID:29201027   PMID:29266319   PMID:29283442   PMID:29452101  
PMID:29459677   PMID:29488625   PMID:29555813   PMID:29574762   PMID:29661929   PMID:29673160   PMID:29724658   PMID:29887373   PMID:29890043   PMID:30068389   PMID:30112629   PMID:30127427  
PMID:30201992   PMID:30248443   PMID:30254218   PMID:30352954   PMID:30555475   PMID:30613266   PMID:30665936   PMID:30793469   PMID:30990796   PMID:31025265   PMID:31128962   PMID:31278254  
PMID:31484827   PMID:31619589   PMID:31712428   PMID:31923400   PMID:31924686   PMID:32000896   PMID:32004476   PMID:32019673   PMID:32031571   PMID:32160525   PMID:32182218   PMID:32269530  
PMID:32325033   PMID:32391010   PMID:32424153   PMID:32614387   PMID:32721946   PMID:32808653   PMID:32983173   PMID:33263277   PMID:33278710   PMID:33378665   PMID:33519806   PMID:33561495  
PMID:33632817   PMID:34046031   PMID:34290377   PMID:34301764   PMID:34349768   PMID:34359992   PMID:34607466   PMID:34660334   PMID:34710388   PMID:34717799   PMID:34721382   PMID:34943953  
PMID:35021079   PMID:35245089   PMID:35577558   PMID:36038541   PMID:36044899   PMID:36252109   PMID:36377658   PMID:36385153   PMID:36451006   PMID:36548474   PMID:36727849   PMID:36883955  
PMID:36894047   PMID:36899931   PMID:37169859   PMID:37190073   PMID:37234375   PMID:37291976   PMID:37440306   PMID:37453365   PMID:37572656   PMID:37676935   PMID:37723490   PMID:37735154  
PMID:37996700   PMID:38362594   PMID:38492223   PMID:38498004  


Genomics

Comparative Map Data
Arg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391024,791,105 - 24,803,368 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1024,791,119 - 24,803,382 (-)EnsemblGRCm39 Ensembl
GRCm381024,915,207 - 24,927,470 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1024,915,221 - 24,927,484 (-)EnsemblGRCm38mm10GRCm38
MGSCv371024,635,013 - 24,647,276 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361024,604,637 - 24,617,896 (-)NCBIMGSCv36mm8
Celera1025,846,180 - 25,858,528 (-)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1012.26NCBI
ARG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386131,573,226 - 131,584,329 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6131,470,832 - 131,584,332 (+)EnsemblGRCh38hg38GRCh38
GRCh376131,894,366 - 131,905,469 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366131,936,058 - 131,947,161 (+)NCBINCBI36Build 36hg18NCBI36
Build 346131,936,057 - 131,947,161NCBI
Celera6132,641,003 - 132,652,108 (+)NCBICelera
Cytogenetic Map6q23.2NCBI
HuRef6129,475,527 - 129,486,657 (+)NCBIHuRef
CHM1_16132,158,130 - 132,169,259 (+)NCBICHM1_1
T2T-CHM13v2.06132,767,703 - 132,778,804 (+)NCBIT2T-CHM13v2.0
Arg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8122,295,093 - 22,307,720 (+)NCBIGRCr8
mRatBN7.2120,475,878 - 20,488,422 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl120,475,968 - 20,488,422 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx120,252,638 - 20,265,091 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0126,252,577 - 26,265,080 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0120,452,538 - 20,464,985 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0121,525,421 - 21,537,872 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl121,525,421 - 21,537,863 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0123,005,260 - 23,017,714 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4120,998,894 - 21,011,275 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1120,999,006 - 21,011,333 (+)NCBI
Celera119,228,309 - 19,241,078 (+)NCBICelera
Cytogenetic Map1p12NCBI
Arg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543612,235,767 - 12,251,972 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543612,235,767 - 12,247,817 (+)NCBIChiLan1.0ChiLan1.0
ARG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25151,578,718 - 151,592,958 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16149,485,403 - 149,496,465 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06129,372,747 - 129,383,880 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16133,479,966 - 133,491,162 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6133,479,966 - 133,491,162 (+)Ensemblpanpan1.1panPan2
ARG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.112242,717 - 255,736 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl12242,714 - 255,305 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha12380,548 - 393,575 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.012386,327 - 399,472 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.112243,210 - 256,371 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.012313,845 - 327,006 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.012384,828 - 398,005 (-)NCBIUU_Cfam_GSD_1.0
ARG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl132,006,046 - 32,028,988 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1132,006,035 - 32,028,983 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2135,580,471 - 35,603,458 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11341,971,955 - 41,983,372 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1341,971,802 - 41,983,049 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604014,133,035 - 14,144,266 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247535,737,237 - 5,752,966 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247535,737,720 - 5,749,313 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Arg1
558 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:121
Count of miRNA genes:107
Interacting mature miRNAs:116
Transcripts:ENSMUST00000020161
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11532718Sluc44f_msusceptibility to lung cancer 44f (mouse)10126289265Mouse
11532717Sluc44g_msusceptibility to lung cancer 44g (mouse)10126289265Mouse
1300881Sluc29_msusceptibility to lung cancer 29 (mouse)Not determined10126289265Mouse
12879494Facq1_mfear acquisition QTL 1 (mouse)10131279130Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
1302160Mbis2_mMycobacterium bovis-induced systemic lupus erythematosus 2 (mouse)Not determined102028318556031223Mouse
1300759Geot_mgeotaxia (mouse)Not determined10126289265Mouse
1558865Lith21_mlithogenic gene 21 (mouse)Not determined10852500342525126Mouse
15039341Nmrs28_mNAFLD-associated magnetic resonance shift 28 (mouse)1035100134351001Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
1301659Arrd2_mage-related retinal degeneration 2 (mouse)Not determined102028318526890391Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1300997Eae15_msusceptibility to experimental allergic encephalomyelitis 15 (mouse)Not determined10440815438408276Mouse
1301003Lmblgq4_mlimb length QTL 4 (mouse)Not determined102159119268091639Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
11532725Sluc44b_msusceptibility to lung cancer 44b (mouse)10126289265Mouse
1301129Alcp15_malcohol preference locus 15 (mouse)Not determined10989026443890391Mouse
10755518Chol16_mcholesterol 16 (mouse)101891504352915043Mouse
11532724Sluc44c_msusceptibility to lung cancer 44c (mouse)10126289265Mouse
1301448Pas11_mpulmonary adenoma susceptibility 11 (mouse)Not determined10989026443890391Mouse
11532723Sluc44d_msusceptibility to lung cancer 44d (mouse)10126289265Mouse
11532722Sluc44e_msusceptibility to lung cancer 44e (mouse)10126289265Mouse
11532721Sluc44_msusceptibility to lung cancer 44 (mouse)10126289265Mouse
1558857Igan1_mIgA nephropathy 1 (mouse)Not determined101771831329704155Mouse
11532720Sluc44a_msusceptibility to lung cancer 44a (mouse)10126289265Mouse
1302092Ath11_matherosclerosis 11 (mouse)Not determined10615194558693521Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
1357813Ath20_matherosclerosis 20 (mouse)Not determined10328318537283334Mouse
1300790Pgia6_mproteoglycan induced arthritis 6 (mouse)Not determined10381017137810295Mouse
1302133Alcp16_malcohol preference locus 16 (mouse)Not determined10989026443890391Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884394Humsd3_mhumerus midshaft diameter 3, 10 week (mouse)102237589951076096Mouse
11533917Mts2_mmammary tumor susceptibility 2 (mouse)10126289265Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
13208570Bmiq9_mbody mass index QTL 9 (mouse)101287574424875898Mouse
1301796Mop2_mmorphine preference 2 (mouse)Not determined10928911929028424Mouse
13208561Wght8_mweight 8 (mouse)10495000043875996Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse

Markers in Region
AI256583  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381024,915,536 - 24,915,650UniSTSGRCm38
MGSCv371024,635,342 - 24,635,456UniSTSGRCm37
Celera1025,846,509 - 25,846,623UniSTS
Cytogenetic Map10A4UniSTS
Whitehead/MRC_RH10285.94UniSTS
Arg1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10A4UniSTS
cM MapUN UniSTS
cM Map10 UniSTS
Arg1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10A4UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000020161   ⟹   ENSMUSP00000020161
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1024,791,119 - 24,803,382 (-)Ensembl
GRCm38.p6 Ensembl1024,915,221 - 24,927,484 (-)Ensembl
Ensembl Acc Id: ENSMUST00000218260
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1024,791,673 - 24,792,305 (-)Ensembl
GRCm38.p6 Ensembl1024,915,775 - 24,916,407 (-)Ensembl
Ensembl Acc Id: ENSMUST00000220186
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1024,798,016 - 24,803,335 (-)Ensembl
GRCm38.p6 Ensembl1024,922,118 - 24,927,437 (-)Ensembl
RefSeq Acc Id: NM_007482   ⟹   NP_031508
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391024,791,105 - 24,803,368 (-)NCBI
GRCm381024,915,207 - 24,927,470 (-)ENTREZGENE
MGSCv371024,635,013 - 24,647,276 (-)RGD
Celera1025,846,180 - 25,858,528 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_031508   ⟸   NM_007482
- UniProtKB: Q4FK78 (UniProtKB/Swiss-Prot),   Q3UEL0 (UniProtKB/Swiss-Prot),   Q3TB74 (UniProtKB/Swiss-Prot),   Q80VI4 (UniProtKB/Swiss-Prot),   Q61176 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000020161   ⟸   ENSMUST00000020161

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61176-F1-model_v2 AlphaFold Q61176 1-323 view protein structure

Promoters
RGD ID:6819006
Promoter ID:MM_KWN:3774
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:NM_007482
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361024,646,911 - 24,647,411 (-)MPROMDB
RGD ID:8671678
Promoter ID:EPDNEW_M13870
Type:initiation region
Name:Arg1_1
Description:Mus musculus arginase, liver , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381024,927,452 - 24,927,512EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88070 AgrOrtholog
Ensembl Genes ENSMUSG00000019987 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000020161 ENTREZGENE
  ENSMUST00000020161.10 UniProtKB/Swiss-Prot
Gene3D-CATH Ureohydrolase domain UniProtKB/Swiss-Prot
InterPro Arginase UniProtKB/Swiss-Prot
  Ureohydrolase UniProtKB/Swiss-Prot
  Ureohydrolase_dom_sf UniProtKB/Swiss-Prot
  Ureohydrolase_Mn_BS UniProtKB/Swiss-Prot
KEGG Report mmu:11846 UniProtKB/Swiss-Prot
MGD MGI:88070 ENTREZGENE
NCBI Gene 11846 ENTREZGENE
PANTHER ARGINASE-1 UniProtKB/Swiss-Prot
  PTHR43782 UniProtKB/Swiss-Prot
Pfam Arginase UniProtKB/Swiss-Prot
PhenoGen Arg1 PhenoGen
PIRSF Arginase UniProtKB/Swiss-Prot
PRINTS ARGINASE UniProtKB/Swiss-Prot
PROSITE ARGINASE_1 UniProtKB/Swiss-Prot
  ARGINASE_2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52768 UniProtKB/Swiss-Prot
UniProt ARGI1_MOUSE UniProtKB/Swiss-Prot
  Q3TB74 ENTREZGENE
  Q3UEL0 ENTREZGENE
  Q4FK78 ENTREZGENE
  Q61176 ENTREZGENE
  Q80VI4 ENTREZGENE
UniProt Secondary Q3TB74 UniProtKB/Swiss-Prot
  Q3UEL0 UniProtKB/Swiss-Prot
  Q4FK78 UniProtKB/Swiss-Prot
  Q80VI4 UniProtKB/Swiss-Prot