APOE (apolipoprotein E) - Rat Genome Database

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Gene: APOE (apolipoprotein E) Homo sapiens
Symbol: APOE
Name: apolipoprotein E
RGD ID: 736378
HGNC Page HGNC:613
Description: Enables several functions, including amyloid-beta binding activity; heparan sulfate proteoglycan binding activity; and lipoprotein particle receptor binding activity. Involved in several processes, including lipid transport; regulation of lipid transport; and regulation of protein metabolic process. Acts upstream of or within with a positive effect on AMPA glutamate receptor clustering and NMDA glutamate receptor clustering. Acts upstream of or within negative regulation of dendritic spine development; positive regulation of dendritic spine development; and regulation of dendritic spine maintenance. Located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and extracellular exosome. Part of several cellular components, including chylomicron; low-density lipoprotein particle; and triglyceride-rich plasma lipoprotein particle. Is active in glutamatergic synapse and synaptic cleft. Implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); biliary tract cancer (multiple); eye disease (multiple); and familial hyperlipidemia (multiple). Biomarker of several diseases, including Lewy body dementia; diabetes mellitus (multiple); end stage renal disease; neurodegenerative disease (multiple); and obesity.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AD2; Alzheimer disease 2 (APOE*E4-associated, late onset); apo-E; ApoE4; apolipoprotein E3; LDLCQ5; LPG; MGC1571
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Is Marker For: Strains:   SD-Apoetm1(APOE*)Sage  
QTLs:   SCL22_H  
Candidate Gene For: BW139_H
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381944,905,796 - 44,909,393 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1944,905,791 - 44,909,393 (+)EnsemblGRCh38hg38GRCh38
GRCh371945,409,053 - 45,412,650 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,100,879 - 50,104,490 (+)NCBINCBI36Build 36hg18NCBI36
Build 341950,100,878 - 50,104,489NCBI
Celera1942,213,361 - 42,216,972 (+)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1941,839,825 - 41,843,436 (+)NCBIHuRef
CHM1_11945,411,793 - 45,415,404 (+)NCBICHM1_1
T2T-CHM13v2.01947,730,492 - 47,734,089 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (IAGP,ISO)
adenocarcinoma  (EXP)
age related macular degeneration 1  (IAGP)
Alzheimer's disease  (EXP,IAGP,IEA,IEP,ISO)
Alzheimer's disease 2  (IAGP)
Alzheimer's disease 3  (IAGP)
Alzheimer's disease 4  (EXP,IAGP)
Alzheimer's Disease, Familial, 3, with Spastic Paraparesis and Apraxia  (EXP)
amyloidosis  (EXP)
amyotrophic lateral sclerosis  (IAGP)
angle-closure glaucoma  (IAGP)
anxiety disorder  (EXP)
aortic atherosclerosis  (ISO)
Apolipoprotein E, Deficiency or Defect of  (IAGP)
arteriosclerosis  (EXP)
atherosclerosis  (EXP,IMP,ISO)
atopic dermatitis  (IDA)
B-Cell Chronic Lymphocytic Leukemia  (IAGP)
beta thalassemia  (IEP)
bile duct cancer  (IAGP)
Brain Injuries  (IEA)
breast cancer  (IAGP)
Broad-Betalipoproteinemia  (IAGP)
cardiovascular system disease  (EXP,IEA)
carotid artery disease  (EXP,IEA)
carotid stenosis  (EXP)
cerebral amyloid angiopathy  (EXP)
Cerebral Hemorrhage  (IAGP)
cerebral infarction  (IAGP)
cerebrovascular disease  (IAGP)
Chemical and Drug Induced Liver Injury  (EXP)
cholelithiasis  (IAGP)
cholestasis  (IEP)
Chronic Brain Injury  (IAGP)
Chronic Cerebral Hypoperfusion  (ISO)
Chronic Hepatitis B  (IAGP)
Chronic Hepatitis C  (IAGP)
cognitive disorder  (EXP)
Cognitive Dysfunction  (IAGP)
congestive heart failure  (IAGP)
coronary artery disease  (IAGP,IEA,ISO)
Coronary Disease  (EXP,IAGP)
Coumarin Sensitivity  (IAGP)
dementia  (IEA)
diabetes mellitus  (IDA)
Diabetic Nephropathies  (IAGP,ISO)
diabetic retinopathy  (IAGP)
dilated cardiomyopathy  (IAGP)
Disease Progression  (EXP)
Dysbetalipoproteinemia due to Defect in Apolipoprotein E-d  (IAGP)
Dyslipidemias  (EXP)
Emphysema  (EXP)
end stage renal disease  (IEP,ISO)
Endotoxemia  (IDA)
exfoliation syndrome  (IAGP)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Mammary Neoplasms  (ISO)
familial combined hyperlipidemia  (IAGP)
Familial Hyperbeta- and Prebetalipoproteinemia  (IAGP)
familial hypercholesterolemia  (IAGP,ISO)
familial hyperlipidemia  (EXP,IEA,ISO)
fatty liver disease  (EXP,ISO)
fetal alcohol spectrum disorder  (ISO)
Fetal Growth Retardation  (ISO)
Fibrosis  (EXP)
Floating-Betalipoproteinemia  (IAGP)
gallbladder cancer  (IAGP)
genetic disease  (IAGP)
Genetic Translocation  (EXP)
glaucoma  (IEA)
glomerulonephritis  (ISO)
glomerulosclerosis  (ISO)
Habitual Abortions  (IAGP)
Hearing Loss  (EXP)
hepatocellular carcinoma  (ISO)
herpes simplex  (IMP)
Herpes Simplex Encephalitis  (IAGP)
herpes simplex virus keratitis  (IDA)
Hypercholesterolemia  (EXP,IAGP,ISO)
hyperhomocysteinemia  (ISO)
Hyperlipemia with Familial Hypercholesterolemic Xanthomatosis  (IAGP)
Hyperlipoproteinemia Type II  (EXP)
hyperlipoproteinemia type III  (EXP,IAGP,IEA)
hypertension  (EXP,IEA,ISO)
Hypertriglyceridemia  (IAGP,IEA,ISO)
hyperuricemia  (IAGP)
hypothyroidism  (ISO)
kidney failure  (EXP)
Klebsiella Infections  (ISO)
Kuhnt-Junius degeneration  (IAGP,IMP)
Lewy body dementia  (IEP)
Lipoprotein Glomerulopathy  (EXP,IAGP,IMP)
low tension glaucoma  (IAGP)
lung carcinoma  (IAGP)
Lung Neoplasms  (EXP)
macular degeneration  (EXP,IAGP,IEA,IMP)
malaria  (IAGP)
membranous glomerulonephritis  (ISO)
Memory Disorders  (IAGP,ISO)
Mercury Poisoning  (EXP)
middle cerebral artery infarction  (ISO)
multiple myeloma  (IDA)
multiple sclerosis  (EXP,IEA)
myocardial infarction  (EXP,IAGP,IEA)
Myocardial Ischemia  (IAGP)
Neoplasm Metastasis  (ISO)
nephrotic syndrome  (IEP)
Nerve Degeneration  (EXP)
Neurobehavioral Manifestations  (EXP)
non-alcoholic fatty liver disease  (ISO)
obesity  (EXP,IEA,IEP,ISO)
open-angle glaucoma  (IAGP)
pancreatic cancer  (IEP)
Parkinson's disease  (IEP)
Peripheral Nerve Injuries  (IDA,ISO)
Plaque, Atherosclerotic  (EXP)
Pregnancy Complications, Infectious  (ISO)
Presenile and Senile Dementia  (IAGP)
primary cutaneous amyloidosis  (IEP)
primary open angle glaucoma  (IAGP)
proteinuria  (EXP)
psoriasis  (EXP,IAGP)
Puromycin Aminonucleoside Nephrosis  (ISO)
relapsing-remitting multiple sclerosis  (EXP)
retinal disease  (IAGP)
schizophrenia  (EXP,IEA)
sciatic neuropathy  (ISO)
sea-blue histiocytosis  (EXP,IAGP)
sensorineural hearing loss  (IAGP)
Sjogren's syndrome  (IAGP)
sleep apnea  (IEA)
Spinal Cord Injuries  (IAGP,ISO)
Splenomegaly  (EXP)
Spontaneous Abortions  (EXP)
Stroke  (IEA)
Subarachnoid Hemorrhage  (IEA)
transient cerebral ischemia  (ISO)
type 1 diabetes mellitus  (IEA,IEP)
type 2 diabetes mellitus  (IEA,IEP)
Vascular System Injuries  (ISO)
Venous Thrombosis  (ISO)
Ventricular Dysfunction, Left  (IAGP)
warfarin resistance  (IAGP)
warfarin sensitivity  (IAGP)
Wilson disease  (EXP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
11-dehydro-thromboxane B2  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-arachidonoylglycerol  (ISO)
2-butoxyethanol  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (EXP)
26-hydroxycholesterol  (ISO)
3',5'-cyclic GMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-Nitrobenzanthrone  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxy-TEMPO  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
6-oxoprostaglandin F1alpha  (ISO)
7,12-dimethyltetraphene  (ISO)
8-epi-prostaglandin F2alpha  (ISO)
acenocoumarol  (EXP)
acetamide  (ISO)
acetylcholine  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrolein  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
amphibole asbestos  (ISO)
arachidonic acid  (EXP,ISO)
aristolochic acid A  (EXP)
Aroclor 1254  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
aspartame  (EXP)
atorvastatin calcium  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (ISO)
bezafibrate  (EXP,ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP,ISO)
BQ 123  (ISO)
Brodifacoum  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
Calcimycin  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
capsaicin  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (EXP)
cetirizine  (ISO)
cetrorelix  (EXP)
chlordecone  (ISO)
chloropicrin  (EXP)
chloroquine  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
cobalt atom  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP)
cypermethrin  (ISO)
D-glucose  (EXP,ISO)
Deoxycorticosterone acetate  (ISO)
desogestrel  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
diazinon  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (EXP,ISO)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (ISO)
dipyridamole  (EXP)
diuron  (ISO)
dorsomorphin  (EXP)
doxorubicin  (ISO)
elemental selenium  (EXP,ISO)
enalapril  (EXP,ISO)
endosulfan  (ISO)
entinostat  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
ethanolamine  (ISO)
felodipine  (ISO)
fenvalerate  (ISO)
Fexofenadine hydrochloride  (ISO)
flusilazole  (ISO)
flutamide  (ISO)
fluvastatin  (EXP)
folic acid  (EXP,ISO)
folpet  (ISO)
furan  (ISO)
Ganoderic acid A  (EXP)
gemfibrozil  (ISO)
genistein  (ISO)
gentamycin  (ISO)
ginkgolide B  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
GW 3965  (EXP,ISO)
GW 4064  (EXP,ISO)
GW 7647  (EXP)
hexadecanoic acid  (ISO)
high-density lipoprotein cholesterol  (EXP,ISO)
hydrazine  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
isotretinoin  (EXP)
ivabradine  (ISO)
ivermectin  (EXP)
kaempferol  (ISO)
kainic acid  (ISO)
ketamine  (EXP,ISO)
kuwanone G  (ISO)
L-ascorbic acid  (ISO)
lansoprazole  (EXP,ISO)
lead diacetate  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
Licochalcone B  (EXP)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
mechlorethamine  (ISO)
menadione  (ISO)
mercury atom  (EXP)
mercury(0)  (EXP)
methyl beta-cyclodextrin  (ISO)
methylmercury chloride  (EXP)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (EXP,ISO)
morphine  (ISO)
Morroniside  (ISO)
myricitrin  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP)
nickel atom  (EXP)
nickel sulfate  (EXP)
nicotine  (ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
nitrofen  (ISO)
NONOate(1-)  (ISO)
notoginsenoside R1  (ISO)
obeticholic acid  (EXP)
ochratoxin A  (ISO)
oleic acid  (EXP)
oxaliplatin  (ISO)
ozone  (ISO)
palbociclib  (EXP)
paracetamol  (EXP,ISO)
paricalcitol  (EXP,ISO)
pentanal  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
permethrin  (ISO)
Phenelzine  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenytoin  (ISO)
phosphorus atom  (EXP)
phosphorus(.)  (EXP)
phytosterols  (ISO)
pirinixic acid  (ISO)
potassium chloride  (ISO)
probucol  (ISO)
propanal  (EXP)
Pyridostigmine bromide  (ISO)
quercetin  (EXP,ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
rotenone  (ISO)
sarin  (EXP)
SB 431542  (EXP)
selenium atom  (EXP,ISO)
sevoflurane  (ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
streptozocin  (ISO)
sunitinib  (EXP)
superoxide  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP,ISO)
taurocholic acid  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (ISO)
theaflavin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
tolcapone  (ISO)
topotecan  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
Trihexyphenidyl  (EXP)
trimellitic anhydride  (ISO)
triolein  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
Tropicamide  (EXP)
trovafloxacin  (ISO)
Tungsten carbide  (EXP)
valproic acid  (EXP,ISO)
valsartan  (EXP)
vanadyl sulfate  (ISO)
varenicline  (ISO)
vitamin E  (ISO)
vitamin K  (EXP)
vitexin  (ISO)
warfarin  (EXP,ISO)
zearalenone  (EXP)
zinc atom  (EXP)
zinc sulfate  (ISO)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
AMPA glutamate receptor clustering  (IDA)
amyloid precursor protein metabolic process  (IDA)
artery morphogenesis  (IEA,ISO)
axon regeneration  (ISO)
cellular oxidant detoxification  (IEA)
cellular response to cholesterol  (ISO)
cellular response to ethanol  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cGMP-mediated signaling  (IDA)
cholesterol catabolic process  (IBA,IEA,ISO)
cholesterol efflux  (IDA,IEA,ISO)
cholesterol homeostasis  (IDA,IEA,IGI,ISO)
cholesterol metabolic process  (IDA,IEA,IMP,ISO)
chylomicron remnant clearance  (IDA,IMP)
circulatory system development  (IEA,ISO)
cytoskeleton organization  (TAS)
fatty acid homeostasis  (IDA)
G protein-coupled receptor signaling pathway  (IDA)
gene expression  (IEA,ISO)
high-density lipoprotein particle assembly  (IDA)
high-density lipoprotein particle clearance  (IDA)
high-density lipoprotein particle remodeling  (IGI)
intermediate-density lipoprotein particle clearance  (IDA)
intermembrane lipid transfer  (IEA)
intracellular calcium ion homeostasis  (IEA,ISO)
intracellular transport  (TAS)
lipid homeostasis  (IEA,ISO)
lipid metabolic process  (IEA)
lipid metabolic process  (ISO)
lipid transport  (IEA,ISO)
lipid transport involved in lipid storage  (IEA,ISS)
lipoprotein biosynthetic process  (IDA,IEA,ISO)
lipoprotein catabolic process  (IBA,IEA,ISO)
lipoprotein metabolic process  (IEA,ISO)
locomotory exploration behavior  (IMP)
long-chain fatty acid transport  (IDA)
long-term memory  (IGI)
low-density lipoprotein particle remodeling  (IEA)
maintenance of location in cell  (IEA,ISO)
melanosome organization  (IEA,IMP)
negative regulation of amyloid fibril formation  (IEA,ISS)
negative regulation of amyloid-beta formation  (IDA)
negative regulation of blood coagulation  (IDA)
negative regulation of blood vessel endothelial cell migration  (IDA)
negative regulation of canonical Wnt signaling pathway  (IDA,IGI,TAS)
negative regulation of cholesterol biosynthetic process  (IDA,ISO)
negative regulation of cholesterol efflux  (IDA)
negative regulation of dendritic spine development  (IDA)
negative regulation of dendritic spine maintenance  (IDA)
negative regulation of endothelial cell migration  (IMP)
negative regulation of endothelial cell proliferation  (IDA)
negative regulation of gene expression  (IEA,ISS)
negative regulation of inflammatory response  (IC)
negative regulation of inflammatory response  (IC)
negative regulation of inflammatory response  (IEA)
negative regulation of lipid biosynthetic process  (IDA)
negative regulation of lipid transport across blood-brain barrier  (IDA)
negative regulation of long-term synaptic potentiation  (IDA)
negative regulation of MAP kinase activity  (IDA)
negative regulation of neuron apoptotic process  (IBA,ISO)
negative regulation of neuron death  (IDA)
negative regulation of neuron projection development  (IDA)
negative regulation of phospholipid efflux  (IDA)
negative regulation of platelet activation  (IDA)
negative regulation of postsynaptic membrane organization  (IDA)
negative regulation of protein metabolic process  (IGI)
negative regulation of protein secretion  (IMP)
negative regulation of smooth muscle cell proliferation  (IEA,ISS)
negative regulation of triglyceride metabolic process  (IEA,ISO)
neuron projection development  (IDA)
nitric oxide mediated signal transduction  (IDA)
NMDA glutamate receptor clustering  (IDA)
obsolete positive regulation of cholesterol esterification  (IDA)
oligodendrocyte differentiation  (ISO)
peripheral nervous system axon regeneration  (ISO)
phospholipid efflux  (IDA)
positive regulation by host of viral process  (IMP)
positive regulation of amyloid fibril formation  (TAS)
positive regulation of amyloid-beta clearance  (IEA,ISS)
positive regulation of amyloid-beta formation  (IDA)
positive regulation of axon extension  (ISO)
positive regulation of cholesterol efflux  (IDA,IEA,IGI)
positive regulation of cholesterol metabolic process  (IDA,IEA)
positive regulation of CoA-transferase activity  (IDA,IEA)
positive regulation of dendritic spine development  (IDA)
positive regulation of dendritic spine maintenance  (IDA)
positive regulation of DNA-templated transcription  (IMP)
positive regulation of endocytosis  (IDA)
positive regulation of ERK1 and ERK2 cascade  (IMP)
positive regulation of heparan sulfate binding  (IDA)
positive regulation of heparan sulfate proteoglycan binding  (IDA)
positive regulation of lipid biosynthetic process  (IDA)
positive regulation of lipid transport across blood-brain barrier  (IDA)
positive regulation of low-density lipoprotein particle receptor catabolic process  (IDA)
positive regulation of membrane protein ectodomain proteolysis  (IDA,IGI)
positive regulation of neurofibrillary tangle assembly  (IDA)
positive regulation of neuron death  (IDA)
positive regulation of neuron projection development  (IDA,IEA,ISS)
positive regulation of nitric-oxide synthase activity  (IBA,IDA)
positive regulation of phospholipid efflux  (IDA)
positive regulation of presynaptic membrane organization  (IDA)
protein import  (IDA)
protein localization  (ISO)
receptor-mediated endocytosis  (IDA,TAS)
regulation of amyloid fibril formation  (IDA)
regulation of amyloid precursor protein catabolic process  (IDA)
regulation of amyloid-beta clearance  (IBA,IDA)
regulation of apoptotic process  (IEA)
regulation of axon extension  (TAS)
regulation of behavioral fear response  (IMP)
regulation of Cdc42 protein signal transduction  (IDA)
regulation of cellular response to very-low-density lipoprotein particle stimulus  (IDA)
regulation of cholesterol metabolic process  (IGI)
regulation of gene expression  (IEA)
regulation of gene expression  (ISO)
regulation of innate immune response  (IEA)
regulation of neuron death  (IDA)
regulation of neuronal synaptic plasticity  (TAS)
regulation of plasma lipoprotein particle levels  (IEA)
regulation of proteasomal protein catabolic process  (IMP)
regulation of protein metabolic process  (IGI)
regulation of protein-containing complex assembly  (IDA)
regulation of synapse organization  (IEA)
regulation of tau-protein kinase activity  (IDA)
regulation of triglyceride metabolic process  (ISO)
response to caloric restriction  (IGI)
response to D-galactosamine  (ISO)
response to dietary excess  (IEA,ISO)
response to ethanol  (ISO)
response to insulin  (ISO)
response to oxidative stress  (IEA,ISO)
response to reactive oxygen species  (NAS)
response to retinoic acid  (ISO)
response to tumor necrosis factor  (ISO)
response to zinc ion  (ISO)
reverse cholesterol transport  (IDA)
steroid metabolic process  (IEA)
synaptic transmission, cholinergic  (TAS)
triglyceride homeostasis  (IEA,ISS)
triglyceride metabolic process  (IDA,IMP)
triglyceride-rich lipoprotein particle clearance  (IEA,IMP)
vasodilation  (IEA,ISO)
very-low-density lipoprotein particle clearance  (IDA,IMP)
very-low-density lipoprotein particle remodeling  (IDA,IEA,IGI)
virion assembly  (IMP)

Cellular Component
blood microparticle  (HDA)
cell surface  (ISO)
chylomicron  (IDA,IEA,ISO)
clathrin-coated endocytic vesicle membrane  (TAS)
collagen-containing extracellular matrix  (HDA)
cytoplasm  (ISO)
cytoplasm  (NAS)
cytoplasm  (NAS,TAS)
cytoplasm  (TAS)
dendrite  (ISO,NAS)
discoidal high-density lipoprotein particle  (ISO,TAS)
early endosome  (ISO,TAS)
endocytic vesicle lumen  (TAS)
endoplasmic reticulum  (IDA)
endoplasmic reticulum  (IDA)
endoplasmic reticulum  (ISO)
endoplasmic reticulum lumen  (TAS)
endosome  (IEA,ISO)
extracellular exosome  (HDA)
extracellular exosome  (HDA,IDA)
extracellular matrix  (IDA)
extracellular matrix  (IDA)
extracellular region  (HDA,IDA,IEA,TAS)
extracellular space  (HDA,IDA,IEA,ISO,ISS)
extracellular vesicle  (HDA)
extrinsic component of external side of plasma membrane  (ISO)
glutamatergic synapse  (IDA,IEA,IEP)
Golgi apparatus  (IDA)
Golgi apparatus  (IDA)
Golgi apparatus  (ISO)
high-density lipoprotein particle  (IDA,IEA,ISO)
intermediate-density lipoprotein particle  (IBA,IDA)
late endosome  (ISO)
lipoprotein particle  (IDA)
low-density lipoprotein particle  (IDA,IEA,ISO)
lysosome  (ISO)
melanosome  (IDA)
membrane  (HDA)
membrane  (HDA)
microtubule  (ISO)
multivesicular body  (IEA)
multivesicular body, internal vesicle  (IDA)
neuronal cell body  (ISO,NAS)
nuclear envelope  (ISO)
nucleus  (HDA)
nucleus  (HDA)
plasma membrane  (ISO)
plasma membrane  (TAS)
plasma membrane  (TAS)
synapse  (ISO)
synaptic cleft  (IDA,IEP)
very-low-density lipoprotein particle  (IDA,IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Abnormal cerebral vascular morphology  (IAGP)
Abnormal circulating apolipoprotein concentration  (IAGP)
Abnormal circulating cholesterol concentration  (IAGP)
Abnormal circulating lipid concentration  (IAGP)
Abnormal renal glomerulus morphology  (IAGP)
Abnormality of extrapyramidal motor function  (IAGP)
Absent axillary hair  (IAGP)
Accelerated atherosclerosis  (IAGP)
Acute pancreatitis  (IAGP)
Adult onset  (IAGP)
Agnosia  (IAGP)
Alzheimer disease  (IAGP)
Angina pectoris  (IAGP)
Aortic atherosclerotic lesion  (IAGP)
Apraxia  (IAGP)
Autosomal dominant inheritance  (IAGP)
Autosomal recessive inheritance  (IAGP)
Babinski sign  (IAGP)
Blepharitis  (IAGP)
Cerebral amyloid angiopathy  (IAGP)
Cerebral cortical atrophy  (IAGP)
Choroidal neovascularization  (IAGP)
Cirrhosis  (IAGP)
Corneal arcus  (IAGP)
Cotton wool plaques  (IAGP)
Decreased HDL cholesterol concentration  (IAGP)
Decreased LDL cholesterol concentration  (IAGP)
Dementia  (IAGP)
Diabetes mellitus  (IAGP)
Dysarthria  (IAGP)
Dysphagia  (IAGP)
Dystonia  (IAGP)
Edema  (IAGP)
Elevated circulating alanine aminotransferase concentration  (IAGP)
Elevated circulating aspartate aminotransferase concentration  (IAGP)
Foam cells  (IAGP)
Foveal hypopigmentation  (IAGP)
Gait disturbance  (IAGP)
Geographic atrophy  (IAGP)
Glomerulopathy  (IAGP)
Gout  (IAGP)
Hepatic steatosis  (IAGP)
Hepatomegaly  (IAGP)
Hypercholesterolemia  (IAGP)
Hyperpigmentation of the skin  (IAGP)
Hypertriglyceridemia  (IAGP)
Hyperuricemia  (IAGP)
Hypopigmentation of the skin  (IAGP)
Hypothyroidism  (IAGP)
Impaired visuospatial constructive cognition  (IAGP)
Increased LDL cholesterol concentration  (IAGP)
Increased total bilirubin  (IAGP)
Invasive parasitic infection  (IAGP)
Late onset  (IAGP)
Long-tract signs  (IAGP)
Lower limb hyperreflexia  (IAGP)
Macular degeneration  (IAGP)
Macular drusen  (IAGP)
Macular hemorrhage  (IAGP)
Mediastinal lymphadenopathy  (IAGP)
Memory impairment  (IAGP)
Mesangial hypercellularity  (IAGP)
Middle age onset  (IAGP)
Myocardial infarction  (IAGP)
Myoclonus  (IAGP)
Neurofibrillary tangles  (IAGP)
Obesity  (IAGP)
Optic ataxia  (IAGP)
Parietal hypometabolism in FDG PET  (IAGP)
Parkinsonism  (IAGP)
Peripheral arterial stenosis  (IAGP)
Personality changes  (IAGP)
Petechiae  (IAGP)
Premature coronary artery atherosclerosis  (IAGP)
Progressive visual loss  (IAGP)
Proteinuria  (IAGP)
Pulmonary infiltrates  (IAGP)
Rapidly progressive  (IAGP)
Renal insufficiency  (IAGP)
Renal steatosis  (IAGP)
Retinopathy  (IAGP)
Sea-blue histiocytosis  (IAGP)
Seizure  (IAGP)
Senile plaques  (IAGP)
Sleep-wake cycle disturbance  (IAGP)
Spastic tetraparesis  (IAGP)
Splenomegaly  (IAGP)
Subcutaneous nodule  (IAGP)
Tendon xanthomatosis  (IAGP)
Thrombocytopenia  (IAGP)
Transient hyperlipidemia  (IAGP)
Type IV atherosclerotic lesion  (IAGP)
Viral hepatitis  (IAGP)
Xanthelasma  (IAGP)

References - curated
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