Pdx1 (pancreatic and duodenal homeobox 1) - Rat Genome Database

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Gene: Pdx1 (pancreatic and duodenal homeobox 1) Mus musculus
Analyze
Symbol: Pdx1
Name: pancreatic and duodenal homeobox 1
RGD ID: 736368
MGI Page MGI
Description: Enables DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in positive regulation of insulin secretion and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including digestive system development; regulation of DNA-templated transcription; and regulation of epithelial cell proliferation. Located in nuclear speck. Is expressed in several structures, including genitourinary system; gut; liver and biliary system; sensory organ; and skeleton. Used to study maturity-onset diabetes of the young; maturity-onset diabetes of the young type 4; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in cerebral infarction; hyperglycemia; maturity-onset diabetes of the young type 4; pancreatic agenesis; and type 2 diabetes mellitus. Orthologous to human PDX1 (pancreatic and duodenal homeobox 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IDX-; IDX-1; insulin promoter factor 1, homeodomain transcription factor; Ip; IPF; IPF-1; Ipf1; islet/duodenum homeobox 1; Mody; Mody4; pancreas/duodenum homeobox protein 1; pancreatic and duodenal homeobox gene 1; pdx-; pdx-1; somatostatin-transactivating factor 1; STF-; STF-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395147,206,907 - 147,212,658 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5147,206,769 - 147,212,658 (+)EnsemblGRCm39 Ensembl
GRCm385147,270,097 - 147,275,848 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5147,269,959 - 147,275,848 (+)EnsemblGRCm38mm10GRCm38
MGSCv375148,081,707 - 148,086,725 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365147,580,475 - 147,586,196 (+)NCBIMGSCv36mm8
Celera5145,261,170 - 145,266,188 (+)NCBICelera
Cytogenetic Map5G3NCBI
cM Map586.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-aminobenzamide  (ISO)
4-phenylbutyric acid  (EXP)
5-fluorouracil  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
9-cis-retinoic acid  (EXP,ISO)
acetic acid  (EXP)
acrylamide  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP)
all-trans-retinol  (EXP)
alloxan  (ISO)
amiloride  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
boric acid  (EXP)
bromochloroacetic acid  (EXP)
calyculin a  (EXP,ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
choline  (EXP)
cordycepin  (ISO)
cytochalasin D  (ISO)
D-glucose  (EXP,ISO)
dexamethasone  (ISO)
diazoxide  (ISO)
diethylstilbestrol  (ISO)
disodium selenite  (EXP)
ebselen  (EXP)
flavonoids  (ISO)
folic acid  (EXP)
fonofos  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gallic acid  (EXP)
Geniposide  (ISO)
Ginsenoside Rh4  (EXP,ISO)
glucose  (EXP,ISO)
harmine  (ISO)
hexadecanoic acid  (EXP,ISO)
hydrogen peroxide  (ISO)
L-methionine  (EXP)
LY294002  (ISO)
Magnolol  (ISO)
metformin  (EXP)
methylglyoxal  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
Nonylphenol  (ISO)
okadaic acid  (EXP,ISO)
paracetamol  (ISO)
parathion  (ISO)
perfluorodecanoic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctanoic acid  (EXP)
potassium dichromate  (EXP)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
SB 203580  (EXP,ISO)
selenic acid  (EXP)
sodium arsenite  (EXP,ISO)
streptozocin  (EXP)
terbufos  (ISO)
tributylstannane  (ISO)
wortmannin  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
cell differentiation  (ISO)
cell population proliferation  (IMP)
digestive tract development  (IMP)
DNA-templated transcription  (ISO)
endocrine pancreas development  (IMP)
enteroendocrine cell differentiation  (IMP)
epithelial cell proliferation  (IMP)
exocrine pancreas development  (IMP)
glucose homeostasis  (IGI,IMP)
glucose mediated signaling pathway  (ISO)
glucose metabolic process  (IDA)
insulin secretion  (ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IMP)
liver development  (IMP)
morphogenesis of embryonic epithelium  (IMP)
negative regulation of cell population proliferation  (IMP)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (IMP)
negative regulation of epithelial cell proliferation  (IMP)
negative regulation of transcription by RNA polymerase II  (IDA)
negative regulation of type B pancreatic cell apoptotic process  (IMP)
pancreas development  (IMP,ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA binding  (ISO)
positive regulation of DNA-templated transcription  (IDA,ISO)
positive regulation of insulin secretion  (IDA,ISO)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (IMP)
positive regulation of response to biotic stimulus  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
positive regulation of type B pancreatic cell proliferation  (IMP)
regulation of cell population proliferation  (IDA)
regulation of DNA-templated transcription  (IEA)
regulation of gene expression  (ISO)
regulation of transcription by RNA polymerase II  (IBA,IDA,IMP)
response to alkaloid  (ISO)
response to chlorate  (ISO)
response to cytokine  (ISO)
response to fatty acid  (ISO)
response to glucocorticoid  (ISO)
response to glucose  (ISO)
response to iron(II) ion  (ISO)
response to L-leucine  (ISO)
response to lipid  (ISO)
response to nicotine  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to vitamin  (ISO)
response to xenobiotic stimulus  (ISO)
smoothened signaling pathway  (ISO)
stem cell differentiation  (ISO)
transcription by RNA polymerase II  (ISO)
transdifferentiation  (ISO)
type B pancreatic cell apoptotic process  (IMP)
type B pancreatic cell differentiation  (IBA,IMP,ISO)
type B pancreatic cell proliferation  (IMP)

Cellular Component
cytoplasm  (IEA)
cytosol  (TAS)
nuclear speck  (IDA)
nucleoplasm  (ISO,TAS)
nucleus  (IBA,IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal bile duct development  (IAGP)
abnormal digestive system morphology  (IAGP)
abnormal duodenum morphology  (IAGP)
abnormal endocrine pancreas morphology  (IAGP)
abnormal enteroendocrine cell morphology  (IAGP)
abnormal foregut morphology  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal liver development  (IAGP)
abnormal mitochondrial physiology  (IAGP)
abnormal pancreas development  (IAGP)
abnormal pancreas morphology  (IAGP)
abnormal pancreatic acinar cell morphology  (IAGP)
abnormal pancreatic beta cell apoptosis  (IAGP)
abnormal pancreatic beta cell differentiation  (IAGP)
abnormal pancreatic beta cell morphology  (IAGP)
abnormal pancreatic beta cell physiology  (IAGP)
abnormal pancreatic delta cell morphology  (IAGP)
abnormal pancreatic duct morphology  (IAGP)
abnormal pancreatic endocrine progenitor cell physiology  (IAGP)
abnormal pancreatic epsilon cell morphology  (IAGP)
abnormal pancreatic islet cell apoptosis  (IAGP)
abnormal pancreatic islet morphology  (IAGP)
abnormal pancreatic islet size  (IAGP)
abnormal PP cell morphology  (IAGP)
abnormal pyloric sphincter morphology  (IAGP)
abnormal small intestine morphology  (IAGP)
abnormal small intestine placement  (IAGP)
abnormal stomach enteroendocrine cell morphology  (IAGP)
abnormal stomach morphology  (IAGP)
abnormal stomach pyloric region morphology  (IAGP)
abnormal tricarboxylic acid cycle  (IAGP)
absent Brunner's glands  (IAGP)
absent pancreas  (IAGP)
decreased amylin secretion  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased insulin secretion  (IAGP)
decreased pancreas weight  (IAGP)
decreased pancreatic alpha cell mass  (IAGP)
decreased pancreatic beta cell mass  (IAGP)
decreased pancreatic beta cell number  (IAGP)
decreased pancreatic beta cell proliferation  (IAGP)
decreased pancreatic islet number  (IAGP)
dehydration  (IAGP)
disorganized pancreatic islets  (IAGP)
distended stomach  (IAGP)
exocrine pancreas hyperplasia  (IAGP)
exocrine pancreatic insufficiency  (IAGP)
hyperglycemia  (IAGP)
impaired glucose tolerance  (IAGP)
improved glucose tolerance  (IAGP)
increased cell proliferation  (IAGP)
increased circulating glucose level  (IAGP)
increased glucagon secretion  (IAGP)
increased insulin sensitivity  (IAGP)
increased pancreatic alpha cell number  (IAGP)
increased pancreatic alpha cell proliferation  (IAGP)
increased pancreatic beta cell apoptosis  (IAGP)
increased pancreatic delta cell number  (IAGP)
increased pancreatic ductal adenocarcinoma incidence  (IAGP)
increased pancreatic intraepithelial neoplasia incidence  (IAGP)
increased PP cell number  (IAGP)
increased urine glucose level  (IAGP)
no abnormal phenotype detected  (IAGP)
pancreas cyst  (IAGP)
pancreas hypoplasia  (IAGP)
pancreas inflammation  (IAGP)
pancreatic acinar hypoplasia  (IAGP)
pancreatic islet hyperplasia  (IAGP)
pancreatic islet hypoplasia  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, complete penetrance  (IEA)
small pancreas  (IAGP)
small pancreatic islets  (IAGP)
sparse hair  (IAGP)
stomach epithelial hyperplasia  (IAGP)
thin skin  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Ahlgren U, etal., Genes Dev. 1998 Jun 15;12(12):1763-8.
2. A hierarchical analysis of transcriptome alterations in intrauterine growth restriction (IUGR) reveals common pathophysiological pathways in mammals. Buffat C, etal., J Pathol. 2007 Nov;213(3):337-46.
3. High glucose is necessary for complete maturation of Pdx1-VP16-expressing hepatic cells into functional insulin-producing cells. Cao LZ, etal., Diabetes. 2004 Dec;53(12):3168-78.
4. Reversal of streptozotocin-induced diabetes in rats by gene therapy with betacellulin and pancreatic duodenal homeobox-1. Chen S, etal., Gene Ther. 2007 Jul;14(14):1102-10. Epub 2007 Apr 26.
5. Functional and molecular defects of pancreatic islets in human type 2 diabetes. Del Guerra S, etal., Diabetes. 2005 Mar;54(3):727-35.
6. Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: an ex vivo gene therapy approach. Fodor A, etal., Diabetologia. 2007 Jan;50(1):121-30. Epub 2006 Nov 28.
7. Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets. Hagman DK, etal., Diabetes. 2008 Feb;57(2):424-31. Epub 2007 Nov 8.
8. Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus. Hani EH, etal., J Clin Invest. 1999 Nov;104(9):R41-8.
9. In vivo prevention of hyperglycemia also prevents glucotoxic effects on PDX-1 and insulin gene expression. Harmon JS, etal., Diabetes. 1999 Oct;48(10):1995-2000.
10. Cholesterol accumulation and diabetes in pancreatic beta-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity. Ishikawa M, etal., J Lipid Res. 2008 Dec;49(12):2524-34. Epub 2008 Aug 5.
11. Mechanisms of compensatory beta-cell growth in insulin-resistant rats: roles of Akt kinase. Jetton TL, etal., Diabetes. 2005 Aug;54(8):2294-304.
12. Conophylline: a novel differentiation inducer for pancreatic beta cells. Kojima I and Umezawa K, Int J Biochem Cell Biol. 2006;38(5-6):923-30. Epub 2005 Oct 26.
13. c-Kit in early onset of diabetes: a morphological and functional analysis of pancreatic beta-cells in c-KitW-v mutant mice. Krishnamurthy M, etal., Endocrinology. 2007 Nov;148(11):5520-30. Epub 2007 Aug 2.
14. Long-term consumption of fermented soybean-derived Chungkookjang enhances insulinotropic action unlike soybeans in 90% pancreatectomized diabetic rats. Kwon DY, etal., Eur J Nutr. 2007 Feb;46(1):44-52. Epub 2007 Jan 2.
15. Influence of diabetes on the loss of beta cell differentiation after islet transplantation in rats. Laybutt DR, etal., Diabetologia. 2007 Oct;50(10):2117-25. Epub 2007 Jul 20.
16. Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes. Laybutt DR, etal., J Biol Chem. 2003 Jan 31;278(5):2997-3005. Epub 2002 Nov 15.
17. Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells. Leonard J, etal., Mol Endocrinol 1993 Oct;7(10):1275-83.
18. Adeno-associated virus-mediated pancreatic and duodenal homeobox gene-1 expression enhanced differentiation of hepatic oval stem cells to insulin-producing cells in diabetic rats. Li H, etal., J Biomed Sci. 2008 Jul;15(4):487-97. Epub 2008 Feb 6.
19. Activin A and betacellulin: effect on regeneration of pancreatic beta-cells in neonatal streptozotocin-treated rats. Li L, etal., Diabetes 2004 Mar;53(3):608-15.
20. Generation of insulin-producing cells from PDX-1 gene-modified human mesenchymal stem cells. Li Y, etal., J Cell Physiol. 2007 Apr;211(1):36-44.
21. Treatment of Type 1 Diabetes with Adipose Tissue-Derived Stem Cells Expressing Pancreatic Duodenal Homeobox 1. Lin G, etal., Stem Cells Dev. 2009 Feb 26.
22. PDX-1 expression and proliferation of duct epithelial cells after partial pancreatectomy in rats. Liu T, etal., Hepatobiliary Pancreat Dis Int. 2007 Aug;6(4):424-9.
23. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
24. MGDs mouse GO annotations MGD data from the GO Consortium
25. MGD IEA MGD IEA
26. Peroxisome proliferator-activated receptor-gamma regulates expression of PDX-1 and NKX6.1 in INS-1 cells. Moibi JA, etal., Diabetes. 2007 Jan;56(1):88-95.
27. Combining a dipeptidyl peptidase-4 inhibitor, alogliptin, with pioglitazone improves glycaemic control, lipid profiles and beta-cell function in db/db mice. Moritoh Y, etal., Br J Pharmacol. 2009 Jun;157(3):415-26. Epub 2009 Apr 3.
28. Endocrine pancreatic tissue plasticity in obese humans is associated with cytoplasmic expression of PBX-1 in pancreatic ductal cells. Muharram G, etal., Biochem Biophys Res Commun. 2005 Aug 12;333(4):1153-9.
29. alpha-Cell neogenesis in an animal model of IDDM. O'Reilly LA, etal., Diabetes. 1997 Apr;46(4):599-606.
30. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
31. Role of the D76N polymorphism of insulin promoter factor-1 in predisposing to Type 2 diabetes. Owen KR, etal., Diabetologia. 2004 May;47(5):957-8. Epub 2004 May 7.
32. Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1. Park JH, etal., J Clin Invest. 2008 Jun;118(6):2316-24.
33. Exercise improves glucose homeostasis that has been impaired by a high-fat diet by potentiating pancreatic beta-cell function and mass through IRS2 in diabetic rats. Park S, etal., J Appl Physiol. 2007 Nov;103(5):1764-71. Epub 2007 Aug 30.
34. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
35. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
36. Mouse MP Annotation Import Pipeline RGD automated import pipeline
37. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
38. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
39. Expression of the Notch signaling pathway and effect on exocrine cell proliferation in adult rat pancreas. Rooman I, etal., Am J Pathol. 2006 Oct;169(4):1206-14.
40. Development of beta-cells in the native pancreas after pancreas allo-transplantation in the Spontaneously Diabetic Torii rat. Shimada K, etal., J Surg Res. 2008 Apr;145(2):229-37. Epub 2007 Aug 30.
41. Regeneration of beta cells in the native pancreata after syngeneic and allogeneic pancreas transplantations in spontaneously type 2 diabetic Torii rats. Shimada K, etal., Transplant Proc. 2008 Mar;40(2):438-40.
42. Ectopic PDX-1 expression in liver ameliorates type 1 diabetes. Shternhall-Ron K, etal., J Autoimmun. 2007 Mar-May;28(2-3):134-42. Epub 2007 Mar 23.
43. Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat. Stoffers DA, etal., Diabetes. 2003 Mar;52(3):734-40.
44. Induction of PDX-1-positive cells in the main duct during regeneration after acute necrotizing pancreatitis in rats. Taguchi M, etal., J Pathol. 2002 Aug;197(5):638-46.
45. Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance. Tanabe K, etal., PLoS Biol. 2008 Feb;6(2):e37.
46. Expression of transcription factors and precursor cell markers during regeneration of beta cells in pancreata of rats treated with streptozotocin. Tiemann K, etal., Virchows Arch. 2007 Mar;450(3):261-6. Epub 2007 Jan 18.
47. Hydrolysed casein diet protects BB rats from developing diabetes by promoting islet neogenesis. Wang GS, etal., J Autoimmun. 2000 Dec;15(4):407-16.
48. In vitro transdifferentiation of mature hepatocytes into insulin-producing cells. Yamada S, etal., Endocr J. 2006 Dec;53(6):789-95. Epub 2006 Sep 19.
49. Association of genetic variants with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome. Yamada Y, etal., Int J Mol Med. 2008 Jun;21(6):801-8.
Additional References at PubMed
PMID:7490099   PMID:7867492   PMID:7901001   PMID:7935793   PMID:8567692   PMID:8625829   PMID:8631275   PMID:8635654   PMID:8645563   PMID:8661069   PMID:8824813   PMID:8923459  
PMID:8963443   PMID:8986763   PMID:9000074   PMID:9121556   PMID:9126492   PMID:9196008   PMID:9291463   PMID:9315659   PMID:9368764   PMID:9514521   PMID:9584121   PMID:9603782  
PMID:9851981   PMID:9922458   PMID:10349636   PMID:10424881   PMID:10471501   PMID:10471502   PMID:10476967   PMID:10537169   PMID:10559496   PMID:10579983   PMID:10615124   PMID:10652343  
PMID:10677506   PMID:10725233   PMID:10821773   PMID:10825208   PMID:10851133   PMID:10868931   PMID:10903178   PMID:10921901   PMID:11003654   PMID:11042159   PMID:11044404   PMID:11076772  
PMID:11076861   PMID:11118884   PMID:11130726   PMID:11158595   PMID:11217851   PMID:11222142   PMID:11279116   PMID:11287626   PMID:11340100   PMID:11371557   PMID:11423476   PMID:11457885  
PMID:11577200   PMID:11590182   PMID:11692168   PMID:11748146   PMID:11781323   PMID:11784003   PMID:11784004   PMID:11784060   PMID:11825903   PMID:11834421   PMID:11834725   PMID:11897712  
PMID:11904435   PMID:11912494   PMID:11934848   PMID:11960711   PMID:11973269   PMID:11973276   PMID:11994408   PMID:12049785   PMID:12099699   PMID:12145169   PMID:12185368   PMID:12189445  
PMID:12219087   PMID:12221286   PMID:12351178   PMID:12368292   PMID:12437983   PMID:12466851   PMID:12475770   PMID:12477932   PMID:12488434   PMID:12551916   PMID:12559489   PMID:12624426  
PMID:12636919   PMID:12697734   PMID:12702762   PMID:12775714   PMID:12781686   PMID:12815626   PMID:12869553   PMID:12904469   PMID:12917290   PMID:12917329   PMID:12921743   PMID:12933680  
PMID:12971999   PMID:12972592   PMID:14517990   PMID:14550306   PMID:14570708   PMID:14633849   PMID:14641329   PMID:14651921   PMID:14680841   PMID:14699589   PMID:14701942   PMID:14702043  
PMID:14704343   PMID:14706696   PMID:14722613   PMID:14729487   PMID:14736742   PMID:14736744   PMID:14970313   PMID:15031110   PMID:15037986   PMID:15121856   PMID:15124020   PMID:15148392  
PMID:15180990   PMID:15277382   PMID:15280211   PMID:15286800   PMID:15300214   PMID:15328022   PMID:15329346   PMID:15372107   PMID:15381696   PMID:15471960   PMID:15486225   PMID:15496408  
PMID:15562255   PMID:15576401   PMID:15585742   PMID:15587270   PMID:15618518   PMID:15668393   PMID:15677506   PMID:15680365   PMID:15689381   PMID:15734845   PMID:15739225   PMID:15739227  
PMID:15743769   PMID:15747579   PMID:15793245   PMID:15887112   PMID:15888377   PMID:15924147   PMID:15938710   PMID:15944193   PMID:16006527   PMID:16023781   PMID:16026781   PMID:16107537  
PMID:16123346   PMID:16126192   PMID:16141072   PMID:16141073   PMID:16141209   PMID:16147997   PMID:16148004   PMID:16153418   PMID:16166097   PMID:16180138   PMID:16186384   PMID:16192304  
PMID:16230531   PMID:16297379   PMID:16306355   PMID:16326147   PMID:16364283   PMID:16386727   PMID:16399505   PMID:16412423   PMID:16418487   PMID:16423820   PMID:16443760   PMID:16498401  
PMID:16515781   PMID:16518820   PMID:16580660   PMID:16611688   PMID:16627579   PMID:16750430   PMID:16751181   PMID:16794995   PMID:16847327   PMID:16887115   PMID:16892179   PMID:16899237  
PMID:16901969   PMID:16912273   PMID:16951258   PMID:16962573   PMID:16964608   PMID:17001468   PMID:17049510   PMID:17056599   PMID:17110468   PMID:17126328   PMID:17150967   PMID:17158802  
PMID:17185046   PMID:17202186   PMID:17222338   PMID:17259975   PMID:17267606   PMID:17312465   PMID:17317781   PMID:17339028   PMID:17360442   PMID:17400205   PMID:17403901   PMID:17404238  
PMID:17418116   PMID:17478445   PMID:17490618   PMID:17535113   PMID:17537793   PMID:17563382   PMID:17596282   PMID:17609113   PMID:17706592   PMID:17706959   PMID:17761679   PMID:17786244  
PMID:17804764   PMID:17855428   PMID:17900743   PMID:17907201   PMID:17907943   PMID:17928203   PMID:17936263   PMID:17938243   PMID:17979180   PMID:17988662   PMID:17996499   PMID:18036209  
PMID:18058910   PMID:18155690   PMID:18186922   PMID:18199433   PMID:18238854   PMID:18252719   PMID:18287559   PMID:18294628   PMID:18297134   PMID:18313669   PMID:18347078   PMID:18376306  
PMID:18394599   PMID:18452912   PMID:18498355   PMID:18506029   PMID:18519800   PMID:18522939   PMID:18550708   PMID:18554416   PMID:18560595   PMID:18591390   PMID:18591393   PMID:18635606  
PMID:18635610   PMID:18665267   PMID:18708173   PMID:18708284   PMID:18715949   PMID:18718916   PMID:18723011   PMID:18772165   PMID:18772243   PMID:18778483   PMID:18924236   PMID:18951876  
PMID:19056911   PMID:19097184   PMID:19141476   PMID:19148298   PMID:19208343   PMID:19208834   PMID:19223466   PMID:19237535   PMID:19300477   PMID:19301403   PMID:19382941   PMID:19446949  
PMID:19487660   PMID:19487809   PMID:19496967   PMID:19501159   PMID:19502415   PMID:19556507   PMID:19576197   PMID:19619492   PMID:19635472   PMID:19644667   PMID:19651901   PMID:19654319  
PMID:19656489   PMID:19723764   PMID:19766716   PMID:19777593   PMID:19793922   PMID:19799567   PMID:19805515   PMID:19808654   PMID:19833122   PMID:19833727   PMID:19837872   PMID:19855005  
PMID:19882138   PMID:19896480   PMID:19901909   PMID:19913509   PMID:19914171   PMID:20003319   PMID:20025861   PMID:20032056   PMID:20040487   PMID:20043902   PMID:20059953   PMID:20138042  
PMID:20148032   PMID:20170518   PMID:20185815   PMID:20339896   PMID:20413507   PMID:20430747   PMID:20448145   PMID:20479245   PMID:20522595   PMID:20533404   PMID:20534694   PMID:20551221  
PMID:20558340   PMID:20627083   PMID:20637728   PMID:20678473   PMID:20802254   PMID:20808819   PMID:20811152   PMID:20857084   PMID:20869363   PMID:20883684   PMID:20934404   PMID:20934536  
PMID:20942803   PMID:20950489   PMID:20978346   PMID:21042537   PMID:21081123   PMID:21098570   PMID:21220053   PMID:21266405   PMID:21267068   PMID:21270265   PMID:21278380   PMID:21281624  
PMID:21287435   PMID:21293061   PMID:21294959   PMID:21362171   PMID:21399612   PMID:21490060   PMID:21540283   PMID:21596989   PMID:21677750   PMID:21738788   PMID:21786021   PMID:21821004  
PMID:21828183   PMID:21829703   PMID:21852533   PMID:21856296   PMID:21867776   PMID:21873635   PMID:21876171   PMID:21880149   PMID:21888903   PMID:21909240   PMID:21911471   PMID:21913313  
PMID:21926540   PMID:21931641   PMID:21947380   PMID:21953612   PMID:21965615   PMID:21986529   PMID:22013016   PMID:22096075   PMID:22114719   PMID:22135308   PMID:22150363   PMID:22178591  
PMID:22232429   PMID:22253604   PMID:22275141   PMID:22308370   PMID:22387004   PMID:22406641   PMID:22434763   PMID:22434868   PMID:22461559   PMID:22507837   PMID:22529374   PMID:22539496  
PMID:22549877   PMID:22563503   PMID:22669743   PMID:22675211   PMID:22729650   PMID:22745161   PMID:22761608   PMID:22771330   PMID:22865702   PMID:22874919   PMID:22905092   PMID:22980982  
PMID:23006325   PMID:23006330   PMID:23027401   PMID:23031216   PMID:23041971   PMID:23071096   PMID:23093780   PMID:23129807   PMID:23142317   PMID:23175628   PMID:23177622   PMID:23193182  
PMID:23207146   PMID:23266956   PMID:23269676   PMID:23271347   PMID:23316230   PMID:23370147   PMID:23382704   PMID:23408910   PMID:23431054   PMID:23441020   PMID:23449223   PMID:23454691  
PMID:23471965   PMID:23554936   PMID:23603491   PMID:23610061   PMID:23703573   PMID:23770676   PMID:23775765   PMID:23831626   PMID:23852729   PMID:23853095   PMID:23863477   PMID:23863625  
PMID:23873371   PMID:23884891   PMID:23903190   PMID:23927931   PMID:23938296   PMID:23940571   PMID:23946427   PMID:23951403   PMID:23996959   PMID:24009262   PMID:24029239   PMID:24126110  
PMID:24163148   PMID:24194600   PMID:24236044   PMID:24258027   PMID:24292793   PMID:24296718   PMID:24312421   PMID:24324549   PMID:24390927   PMID:24411943   PMID:24449844   PMID:24487024  
PMID:24506867   PMID:24574008   PMID:24658302   PMID:24726366   PMID:24848070   PMID:24952961   PMID:25040025   PMID:25053427   PMID:25063451   PMID:25144761   PMID:25186293   PMID:25209250  
PMID:25251389   PMID:25271154   PMID:25371369   PMID:25523391   PMID:25576928   PMID:25652387   PMID:25695968   PMID:25713082   PMID:25715394   PMID:25715395   PMID:25784544   PMID:25786211  
PMID:25801033   PMID:25817342   PMID:25918232   PMID:26015547   PMID:26021489   PMID:26057579   PMID:26085571   PMID:26156633   PMID:26169832   PMID:26180087   PMID:26440894   PMID:26450967  
PMID:26494286   PMID:26494792   PMID:26516699   PMID:26518685   PMID:26534984   PMID:26554594   PMID:26564177   PMID:26576643   PMID:26631740   PMID:26657766   PMID:26752640   PMID:26771085  
PMID:26887806   PMID:26901059   PMID:26932670   PMID:26994512   PMID:27068127   PMID:27130279   PMID:27137932   PMID:27181524   PMID:27270601   PMID:27292642   PMID:27349930   PMID:27406855  
PMID:27572106   PMID:27736991   PMID:27740873   PMID:27747430   PMID:27789228   PMID:27892540   PMID:27993987   PMID:28017717   PMID:28052057   PMID:28071588   PMID:28087712   PMID:28100774  
PMID:28100871   PMID:28118981   PMID:28193997   PMID:28248965   PMID:28290604   PMID:28441528   PMID:28501476   PMID:28576773   PMID:28580283   PMID:28705881   PMID:28793255   PMID:28922976  
PMID:28928395   PMID:28934293   PMID:29023691   PMID:29058721   PMID:29079704   PMID:29180572   PMID:29259128   PMID:29272356   PMID:29351489   PMID:29637395   PMID:29700203   PMID:29723041  
PMID:29798841   PMID:29875165   PMID:29910119   PMID:30026551   PMID:30065074   PMID:30093553   PMID:30174228   PMID:30305368   PMID:30333365   PMID:30472119   PMID:30487608   PMID:30504829  
PMID:30523046   PMID:30590051   PMID:30620902   PMID:30733468   PMID:30853440   PMID:31006513   PMID:31138815   PMID:31160417   PMID:31201281   PMID:31208980   PMID:31240701   PMID:31323030  
PMID:31337977   PMID:31345937   PMID:31412250   PMID:31604927   PMID:31682591   PMID:31776260   PMID:31806625   PMID:31875961   PMID:31923647   PMID:31953387   PMID:32059775   PMID:32060653  
PMID:32165492   PMID:32243891   PMID:32245798   PMID:32350257   PMID:32404350   PMID:32460029   PMID:32547704   PMID:32552827   PMID:32668405   PMID:32690606   PMID:32857951   PMID:33205075  
PMID:33236139   PMID:33527355   PMID:33569632   PMID:33649537   PMID:33653874   PMID:33658226   PMID:33810480   PMID:33811703   PMID:33852861   PMID:34201511   PMID:34258596   PMID:34267243  
PMID:34302028   PMID:34391772   PMID:34433966   PMID:34462257   PMID:34487921   PMID:34592773   PMID:34645928   PMID:34686326   PMID:34735515   PMID:35015736   PMID:35618699   PMID:35695761  
PMID:35803738   PMID:35998583   PMID:36017799   PMID:36046192   PMID:36100434   PMID:36202974   PMID:36470401   PMID:36529318   PMID:36577717   PMID:36596776   PMID:36607262   PMID:36623733  
PMID:36681690   PMID:36717563   PMID:36899442   PMID:36941669   PMID:37081806   PMID:37096042   PMID:37117185   PMID:37172642   PMID:37175791   PMID:37364986   PMID:37524711   PMID:37536498  
PMID:37610090   PMID:37679611   PMID:37689751   PMID:37739117   PMID:38171340   PMID:38355793   PMID:38505613   PMID:38574509   PMID:38783812  


Genomics

Comparative Map Data
Pdx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395147,206,907 - 147,212,658 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5147,206,769 - 147,212,658 (+)EnsemblGRCm39 Ensembl
GRCm385147,270,097 - 147,275,848 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5147,269,959 - 147,275,848 (+)EnsemblGRCm38mm10GRCm38
MGSCv375148,081,707 - 148,086,725 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365147,580,475 - 147,586,196 (+)NCBIMGSCv36mm8
Celera5145,261,170 - 145,266,188 (+)NCBICelera
Cytogenetic Map5G3NCBI
cM Map586.84NCBI
PDX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381327,920,000 - 27,926,313 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1327,920,000 - 27,926,313 (+)EnsemblGRCh38hg38GRCh38
GRCh371328,494,137 - 28,500,450 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361327,392,157 - 27,397,394 (+)NCBINCBI36Build 36hg18NCBI36
Build 341327,392,176 - 27,397,394NCBI
Celera139,568,879 - 9,575,162 (+)NCBICelera
Cytogenetic Map13q12.2NCBI
HuRef139,314,253 - 9,320,535 (+)NCBIHuRef
CHM1_11328,462,445 - 28,468,728 (+)NCBICHM1_1
T2T-CHM13v2.01327,141,129 - 27,147,442 (+)NCBIT2T-CHM13v2.0
Pdx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81212,793,957 - 12,799,156 (-)NCBIGRCr8
mRatBN7.2127,757,865 - 7,763,064 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl127,757,865 - 7,763,064 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx128,444,089 - 8,449,310 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0129,067,243 - 9,072,462 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0128,095,256 - 8,100,469 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0129,496,044 - 9,501,211 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl129,496,044 - 9,501,213 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01211,609,488 - 11,614,655 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera129,495,501 - 9,500,668 (-)NCBICelera
Cytogenetic Map12p11NCBI
Pdx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554977,281,886 - 7,307,969 (+)NCBIChiLan1.0ChiLan1.0
PDX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21427,506,036 - 27,512,108 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11318,610,792 - 18,616,867 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0139,199,572 - 9,206,202 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11327,545,855 - 27,553,118 (+)NCBIpanpan1.1PanPan1.1panPan2
PDX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12511,741,863 - 11,746,885 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2511,741,863 - 11,746,885 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2511,805,337 - 11,810,359 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02511,870,873 - 11,875,895 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2511,870,873 - 11,875,895 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12511,765,554 - 11,770,575 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02511,758,195 - 11,763,217 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02511,802,135 - 11,807,157 (-)NCBIUU_Cfam_GSD_1.0
Pdx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945172,845,028 - 172,849,677 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647223,102,534 - 23,107,127 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647223,102,534 - 23,107,127 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl115,303,609 - 5,309,063 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1115,303,609 - 5,309,063 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2114,961,177 - 4,966,632 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.137,038,088 - 7,046,593 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl37,041,466 - 7,045,976 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605737,343,264 - 37,348,413 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pdx1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477610,591,855 - 10,596,676 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477610,591,855 - 10,596,738 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pdx1
253 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1178
Count of miRNA genes:635
Interacting mature miRNAs:772
Transcripts:ENSMUST00000085591
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115156883149157015Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115156883149157015Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118948964151758149Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119945037149347326Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121455402151758149Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121555236151758149Mouse
1302079Lbw3_mlupus NZB x NZW 3 (mouse)Not determined5124700335151758149Mouse
1301363Pbwg13_mpostnatal body weight growth 13 (mouse)Not determined5125133457151758149Mouse
4141218Ath24_matherosclerosis 24 (mouse)Not determined129520084151758149Mouse
12880406Jcdq2_mjoint cartilage degeneration QTL 2 (mouse)5129787831151758149Mouse
11049557Lmr26_mleishmaniasis resistance 26 (mouse)5133925558151758149Mouse
13504735Ifvrq7_minfluenza virus resistance QTL 7 (mouse)5139509801151658149Mouse
13504737Ifvrq5_minfluenza virus resistance QTL 5 (mouse)5139509801151658149Mouse
13504734Ifvrq4_minfluenza virus resistance QTL 4 (mouse)5139985755151658149Mouse

Markers in Region
Pdx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv375148,086,473 - 148,086,617UniSTSGRCm37
MGSCv375148,085,982 - 148,086,125UniSTSGRCm37
MGSCv375148,086,131 - 148,086,439UniSTSGRCm37
MGSCv375148,086,105 - 148,086,723UniSTSGRCm37
Celera5145,265,936 - 145,266,080UniSTS
Celera5145,265,445 - 145,265,588UniSTS
Celera5145,265,568 - 145,266,186UniSTS
Celera5145,265,594 - 145,265,902UniSTS
Cytogenetic Map5G3UniSTS
cM Map582.0UniSTS
cM Map582.0UniSTS
cM Map582.0UniSTS
PMC316911P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385147,274,276 - 147,274,521UniSTSGRCm38
MGSCv375148,085,852 - 148,086,097UniSTSGRCm37
Celera5145,265,315 - 145,265,560UniSTS
Cytogenetic Map5G3UniSTS
cM Map582.0UniSTS
PMC317250P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385147,274,416 - 147,275,095UniSTSGRCm38
MGSCv375148,085,992 - 148,086,671UniSTSGRCm37
Celera5145,265,455 - 145,266,134UniSTS
Cytogenetic Map5G3UniSTS
cM Map582.0UniSTS
Pdx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5G3UniSTS
Pdx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5G3UniSTS
cM Map582.0UniSTS
Pdx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5G3UniSTS
Pdx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385147,274,406 - 147,274,549UniSTSGRCm38
MGSCv375148,085,982 - 148,086,125UniSTSGRCm37
Celera5145,265,445 - 145,265,588UniSTS
Cytogenetic Map5G3UniSTS
Pdx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385147,274,897 - 147,275,041UniSTSGRCm38
MGSCv375148,086,473 - 148,086,617UniSTSGRCm37
Celera5145,265,936 - 145,266,080UniSTS
Cytogenetic Map5G3UniSTS
cM Map582.0UniSTS
Pdx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385147,274,529 - 147,275,147UniSTSGRCm38
MGSCv375148,086,105 - 148,086,723UniSTSGRCm37
Celera5145,265,568 - 145,266,186UniSTS
Cytogenetic Map5G3UniSTS
cM Map582.0UniSTS
Pdx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385147,274,555 - 147,274,863UniSTSGRCm38
MGSCv375148,086,131 - 148,086,439UniSTSGRCm37
Celera5145,265,594 - 145,265,902UniSTS
Cytogenetic Map5G3UniSTS
cM Map582.0UniSTS
Pdx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5G3UniSTS
Pdx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5G3UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000085591   ⟹   ENSMUSP00000082729
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5147,206,769 - 147,212,658 (+)Ensembl
GRCm38.p6 Ensembl5147,269,959 - 147,275,848 (+)Ensembl
RefSeq Acc Id: NM_008814   ⟹   NP_032840
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395147,206,907 - 147,212,658 (+)NCBI
GRCm385147,270,097 - 147,275,848 (+)NCBI
MGSCv375148,081,707 - 148,086,725 (+)RGD
Celera5145,261,170 - 145,266,188 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032840   ⟸   NM_008814
- UniProtKB: Q3ZB03 (UniProtKB/Swiss-Prot),   P52946 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000082729   ⟸   ENSMUST00000085591
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P52946-F1-model_v2 AlphaFold P52946 1-284 view protein structure

Promoters
RGD ID:6888802
Promoter ID:EPDNEW_M7852
Type:initiation region
Name:Pdx1_1
Description:Mus musculus pancreatic and duodenal homeobox 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385147,270,097 - 147,270,157EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:102851 AgrOrtholog
Ensembl Genes ENSMUSG00000029644 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000085591 ENTREZGENE
  ENSMUST00000085591.7 UniProtKB/Swiss-Prot
Gene3D-CATH Homeodomain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_antennapedia UniProtKB/Swiss-Prot
  Homeobox_CS UniProtKB/Swiss-Prot
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_metazoa UniProtKB/Swiss-Prot
KEGG Report mmu:18609 UniProtKB/Swiss-Prot
MGD MGI:102851 ENTREZGENE
NCBI Gene 18609 ENTREZGENE
PANTHER PANCREAS/DUODENUM HOMEOBOX PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN ZERKNUELLT 1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pdx1 PhenoGen
PRINTS ANTENNAPEDIA UniProtKB/Swiss-Prot
  HOMEOBOX UniProtKB/Swiss-Prot
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot
  HOMEOBOX_2 UniProtKB/Swiss-Prot
SMART HOX UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P52946 ENTREZGENE, UniProtKB/Swiss-Prot
  Q3ZB03 ENTREZGENE
  Q6LEB3_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3ZB03 UniProtKB/Swiss-Prot