Uchl1 (ubiquitin carboxy-terminal hydrolase L1) - Rat Genome Database

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Gene: Uchl1 (ubiquitin carboxy-terminal hydrolase L1) Mus musculus
Analyze
Symbol: Uchl1
Name: ubiquitin carboxy-terminal hydrolase L1
RGD ID: 736277
MGI Page MGI
Description: Enables cysteine-type deubiquitinase activity; ribosome binding activity; and ubiquitin binding activity. Involved in cellular response to xenobiotic stimulus. Acts upstream of or within several processes, including adult walking behavior; axon target recognition; and male germ cell proliferation. Located in several cellular components, including axon; neuron projection terminus; and neuronal cell body. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; hereditary spastic paraplegia 79A; and hereditary spastic paraplegia 79B. Orthologous to human UCHL1 (ubiquitin C-terminal hydrolase L1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AW822034; C88048; gad; gracile axonal dystrophy; neuron cytoplasmic protein 9.5; PGP 9.5; PGP9; PGP9.5; protein gene product 9.5; R75593; ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin thioesterase L1; UCH-L1; UCHL-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39566,833,464 - 66,844,577 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl566,833,434 - 66,844,577 (+)EnsemblGRCm39 Ensembl
GRCm38566,676,121 - 66,687,234 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl566,676,091 - 66,687,234 (+)EnsemblGRCm38mm10GRCm38
MGSCv37567,067,360 - 67,078,473 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36566,955,425 - 66,966,369 (+)NCBIMGSCv36mm8
Celera563,976,841 - 63,987,914 (+)NCBICelera
Cytogenetic Map5C3.1NCBI
cM Map535.95NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (EXP)
1,2-naphthoquinone  (ISO)
1,3-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2-methoxyethanol  (ISO)
4-hydroxynon-2-enal  (EXP)
4-methylcatechol  (EXP)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
bisphenol A  (ISO)
bisphenol F  (ISO)
buta-1,3-diene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
cannabidiol  (ISO)
carbon nanotube  (EXP)
cefaloridine  (ISO)
chlordecone  (EXP)
chloropicrin  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP)
choline  (EXP)
cobalt atom  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (EXP)
CU-O LINKAGE  (ISO)
Cuprizon  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
daidzein  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
fenvalerate  (ISO)
ferric oxide  (ISO)
flavonoids  (ISO)
folic acid  (EXP)
furan  (ISO)
genistein  (ISO)
glutathione  (ISO)
glycitein  (ISO)
glyphosate  (EXP)
hydrogen peroxide  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
kainic acid  (ISO)
L-methionine  (EXP)
Licochalcone B  (ISO)
lidocaine  (EXP,ISO)
maneb  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dibromide  (ISO)
methamphetamine  (EXP,ISO)
methylmercury chloride  (EXP,ISO)
mevinphos  (ISO)
mitomycin C  (ISO)
mitoxantrone  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
naphthalene  (EXP)
nickel dichloride  (ISO)
nicotine  (EXP)
nitrofen  (ISO)
oxidopamine  (ISO)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenethyl isothiocyanate  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
pinosylvin  (ISO)
pirinixic acid  (EXP,ISO)
progesterone  (ISO)
pyrogallol  (EXP)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
resiniferatoxin  (EXP)
rotenone  (EXP)
rutin  (ISO)
sarin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chromate  (ISO)
sodium fluoride  (EXP)
streptozocin  (ISO)
sulfadimethoxine  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tebufenpyrad  (ISO)
thapsigargin  (ISO)
theophylline  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trans-pinosylvin  (ISO)
trichostatin A  (ISO)
triptonide  (EXP)
Tungsten carbide  (ISO)
valproic acid  (EXP,ISO)
vincristine  (ISO)
vitamin E  (ISO)
zearalenone  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases. Choi J, etal., J Biol Chem. 2004 Mar 26;279(13):13256-64. Epub 2004 Jan 13.
2. Changes in ocular aquaporin-4 (AQP4) expression following retinal injury. Dibas A, etal., Mol Vis. 2008 Sep 25;14:1770-83.
3. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
5. Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia. Kurihara LJ, etal., Hum Mol Genet 2001 Sep 1;10(18):1963-70.
6. The ubiquitin pathway in Parkinson's disease. Leroy E, etal., Nature 1998 Oct 1;395(6701):451-2.
7. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
8. MGDs mouse GO annotations MGD data from the GO Consortium
9. MGD IEA MGD IEA
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. Mouse MP Annotation Import Pipeline RGD automated import pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice. Saigoh K, etal., Nat Genet 1999 Sep;23(1):47-51.
Additional References at PubMed
PMID:1451762   PMID:1630580   PMID:2558488   PMID:3340629   PMID:7504492   PMID:7555927   PMID:7558041   PMID:7600671   PMID:7824161   PMID:8007658   PMID:8041506   PMID:8474599  
PMID:8556328   PMID:8764939   PMID:8812145   PMID:8896700   PMID:9092472   PMID:9697851   PMID:9753148   PMID:9895385   PMID:9922208   PMID:9922227   PMID:10069332   PMID:10096602  
PMID:10212310   PMID:10349636   PMID:10542373   PMID:10588868   PMID:10707974   PMID:10873389   PMID:10922068   PMID:10952889   PMID:10964465   PMID:10974669   PMID:11042159   PMID:11069590  
PMID:11076861   PMID:11357193   PMID:11409167   PMID:11466438   PMID:11549719   PMID:11556531   PMID:11749040   PMID:11776395   PMID:11779477   PMID:11819203   PMID:11819698   PMID:11819726  
PMID:12012374   PMID:12044478   PMID:12074562   PMID:12107488   PMID:12117822   PMID:12216988   PMID:12270041   PMID:12417529   PMID:12466851   PMID:12477932   PMID:12508309   PMID:12559414  
PMID:12620989   PMID:12638230   PMID:12648489   PMID:12668632   PMID:12798294   PMID:12846558   PMID:12866128   PMID:12913066   PMID:14523813   PMID:14562616   PMID:14643680   PMID:14681479  
PMID:14695319   PMID:14755522   PMID:14973275   PMID:15067320   PMID:15084487   PMID:15100241   PMID:15204970   PMID:15207921   PMID:15306232   PMID:15464571   PMID:15466400   PMID:15489334  
PMID:15572147   PMID:15591414   PMID:15604101   PMID:15744022   PMID:15746173   PMID:15829524   PMID:15843399   PMID:15859351   PMID:15878769   PMID:15882581   PMID:15889617   PMID:15911766  
PMID:15937819   PMID:16047381   PMID:16141072   PMID:16141073   PMID:16177983   PMID:16371654   PMID:16439479   PMID:16508210   PMID:16602821   PMID:16632597   PMID:16790476   PMID:16854219  
PMID:16917820   PMID:16919471   PMID:16923396   PMID:16965839   PMID:16989820   PMID:17015430   PMID:17024414   PMID:17071595   PMID:17103415   PMID:17103416   PMID:17355878   PMID:17396120  
PMID:17507395   PMID:17553423   PMID:17595340   PMID:17599367   PMID:17634366   PMID:17698011   PMID:17967198   PMID:18040074   PMID:18070598   PMID:18160648   PMID:18177855   PMID:18250096  
PMID:18279321   PMID:18367558   PMID:18411255   PMID:18460603   PMID:18465790   PMID:18471525   PMID:18498735   PMID:18506029   PMID:18550537   PMID:18628613   PMID:18680569   PMID:18771733  
PMID:18786355   PMID:18830272   PMID:18839409   PMID:19046377   PMID:19141079   PMID:19204867   PMID:19208343   PMID:19235715   PMID:19377830   PMID:19423573   PMID:19474151   PMID:19502490  
PMID:19535597   PMID:19536331   PMID:19580868   PMID:19631635   PMID:19914172   PMID:19924828   PMID:19954489   PMID:20064392   PMID:20080621   PMID:20107080   PMID:20143239   PMID:20147383  
PMID:20231490   PMID:20346763   PMID:20363052   PMID:20457670   PMID:20460112   PMID:20534675   PMID:20572855   PMID:20648571   PMID:20658693   PMID:20668922   PMID:20696247   PMID:20844136  
PMID:20951772   PMID:21220101   PMID:21267068   PMID:21300867   PMID:21302255   PMID:21322090   PMID:21453705   PMID:21543603   PMID:21606356   PMID:21677159   PMID:21678139   PMID:21678411  
PMID:21739582   PMID:21751213   PMID:21770032   PMID:21798254   PMID:21829440   PMID:21873635   PMID:21957238   PMID:21978088   PMID:22028026   PMID:22038515   PMID:22076440   PMID:22103411  
PMID:22186729   PMID:22212137   PMID:22215812   PMID:22223688   PMID:22266424   PMID:22288475   PMID:22331706   PMID:22342763   PMID:22345400   PMID:22355774   PMID:22411557   PMID:22434869  
PMID:22675208   PMID:22689348   PMID:22723301   PMID:22745484   PMID:22828515   PMID:22837015   PMID:22878413   PMID:22988430   PMID:23064229   PMID:23284756   PMID:23297343   PMID:23316968  
PMID:23371862   PMID:23413832   PMID:23449471   PMID:23543736   PMID:23562608   PMID:23567262   PMID:23591430   PMID:23599427   PMID:23644063   PMID:23665221   PMID:23686616   PMID:23900885  
PMID:23926259   PMID:23948231   PMID:24090154   PMID:24107967   PMID:24123561   PMID:24194600   PMID:24516396   PMID:24583340   PMID:24662305   PMID:24732420   PMID:24733831   PMID:24752460  
PMID:24760869   PMID:24770650   PMID:24879150   PMID:24994982   PMID:25041530   PMID:25079316   PMID:25299669   PMID:25403879   PMID:25516972   PMID:25555806   PMID:25596590   PMID:25775587  
PMID:25917818   PMID:25968320   PMID:25997579   PMID:26054056   PMID:26156989   PMID:26178733   PMID:26212662   PMID:26403541   PMID:26453796   PMID:26514267   PMID:26702068   PMID:26781791  
PMID:26857994   PMID:27035151   PMID:27122033   PMID:27334845   PMID:27571008   PMID:28190767   PMID:28397067   PMID:28500221   PMID:28546511   PMID:28726275   PMID:28754552   PMID:28803986  
PMID:28973166   PMID:29382714   PMID:29397366   PMID:29667913   PMID:29686406   PMID:29782494   PMID:29959188   PMID:30068389   PMID:30208315   PMID:30237325   PMID:30257881   PMID:30457570  
PMID:30524266   PMID:30562941   PMID:30594740   PMID:30760601   PMID:30917305   PMID:30923110   PMID:31279265   PMID:31291551   PMID:31356902   PMID:31492742   PMID:31570000   PMID:31597917  
PMID:31781038   PMID:32325033   PMID:32451617   PMID:32606430   PMID:32801299   PMID:32848868   PMID:33030206   PMID:33137160   PMID:33159930   PMID:33288908   PMID:33438509   PMID:33674582  
PMID:33744254   PMID:33958373   PMID:34272903   PMID:34288216   PMID:34321999   PMID:34324195   PMID:34425092   PMID:34508847   PMID:34571914   PMID:34709266   PMID:34789718   PMID:34853443  
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PMID:36303068   PMID:36417873   PMID:36681249   PMID:37055432   PMID:37142655   PMID:37215988   PMID:37452641   PMID:37830619   PMID:38081437   PMID:38212312   PMID:38355793   PMID:38478109  
PMID:38538704   PMID:38581949   PMID:39000437   PMID:39367569  


Genomics

Comparative Map Data
Uchl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39566,833,464 - 66,844,577 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl566,833,434 - 66,844,577 (+)EnsemblGRCm39 Ensembl
GRCm38566,676,121 - 66,687,234 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl566,676,091 - 66,687,234 (+)EnsemblGRCm38mm10GRCm38
MGSCv37567,067,360 - 67,078,473 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36566,955,425 - 66,966,369 (+)NCBIMGSCv36mm8
Celera563,976,841 - 63,987,914 (+)NCBICelera
Cytogenetic Map5C3.1NCBI
cM Map535.95NCBI
UCHL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38441,256,928 - 41,268,455 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl441,256,413 - 41,268,455 (+)EnsemblGRCh38hg38GRCh38
GRCh37441,258,945 - 41,270,472 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36440,953,686 - 40,965,203 (+)NCBINCBI36Build 36hg18NCBI36
Build 34441,099,856 - 41,111,373NCBI
Celera441,702,199 - 41,713,746 (+)NCBICelera
Cytogenetic Map4p13NCBI
HuRef440,580,844 - 40,592,391 (+)NCBIHuRef
CHM1_1441,259,044 - 41,270,591 (+)NCBICHM1_1
T2T-CHM13v2.0441,230,716 - 41,242,242 (+)NCBIT2T-CHM13v2.0
Uchl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81441,838,859 - 41,849,743 (-)NCBIGRCr8
mRatBN7.21441,485,031 - 41,495,590 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1441,485,031 - 41,495,590 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1441,831,048 - 41,841,616 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01443,131,128 - 43,141,696 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01441,611,942 - 41,622,510 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01443,133,224 - 43,143,942 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1443,133,218 - 43,143,973 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01442,928,247 - 42,938,981 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41444,114,392 - 44,124,947 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11444,116,782 - 44,127,338 (-)NCBI
Celera1440,639,549 - 40,650,302 (-)NCBICelera
Cytogenetic Map14p11NCBI
Uchl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554436,367,460 - 6,380,462 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554436,367,519 - 6,379,638 (-)NCBIChiLan1.0ChiLan1.0
UCHL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2341,440,064 - 41,451,601 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1441,633,489 - 41,645,029 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0435,580,755 - 35,592,314 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1441,432,367 - 41,440,129 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl441,428,759 - 41,440,129 (+)Ensemblpanpan1.1panPan2
UCHL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1371,396,694 - 71,430,395 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl371,370,822 - 71,411,350 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha373,946,978 - 73,961,370 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0372,157,557 - 72,171,966 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1371,427,585 - 71,441,983 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0371,589,640 - 71,604,050 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0371,972,745 - 71,987,146 (-)NCBIUU_Cfam_GSD_1.0
Uchl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528537,734,649 - 37,746,530 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364828,551,603 - 8,563,651 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364828,551,749 - 8,563,586 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UCHL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl832,353,246 - 32,367,332 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1832,353,766 - 32,367,288 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2833,970,620 - 33,982,399 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UCHL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1279,074,961 - 9,086,606 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl279,074,923 - 9,086,517 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604755,406,774 - 55,418,174 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Uchl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476125,784,257 - 25,797,549 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476125,786,028 - 25,797,641 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Uchl1
409 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:525
Count of miRNA genes:365
Interacting mature miRNAs:398
Transcripts:ENSMUST00000031131, ENSMUST00000176015, ENSMUST00000177194
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301843Listr1_mlisteriosis resistance 1 (mouse)Not determined56024608194246203Mouse
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined32133234100777931Mouse
1301010ahl2_mage related hearing loss 2 (mouse)Not determined56265056896650688Mouse
10043995Hbnr9_mHeligmosomoides bakeri nematode resistance 9 (mouse)Not determined53348866767488876Mouse
11041899Lmr24a_mleishmaniasis resistance 24a (mouse)552694462107321041Mouse
1300951Gbvq1_mgallstone bladder volume QTL 1 (mouse)Not determined53811168172111798Mouse
14746981Manh57_mmandible shape 57 (mouse)54716974281169742Mouse
1301845Lxw4_mlupus BXSB x NZW 4 (mouse)Not determined53569446269694594Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537581488112465722Mouse
10045972Tir5_mtrypanosome infection response 5 (mouse)Not determined563705442104387065Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
1301698Pcfm4_mperiosteal circumference and femur length 4 (mouse)Not determined54458584378585965Mouse
4142317Rgcs1_mretinal ganglion cell susceptible 1 (mouse)Not determined55388334108762627Mouse
4141219W10q16_mweight 10 weeks QTL 16 (mouse)Not determined32133234100777931Mouse
12904740M1fscn2_mmodifier 1 of Fscn2 (mouse)566529661100529661Mouse
1301170Lith13_mlithogenic gene 13 (mouse)Not determined53649448670494598Mouse
10043962Obq27_mobesity QTL 27 (mouse)Not determined55628565590285655Mouse
4142428Modvl1_mmodifier of vacuolated lens 1 (mouse)Not determined6265056896650688Mouse
11040589Lmr3a_mleishmaniasis resistance 3a (mouse)55960280193602980Mouse
11040590Lmr3b_mleishmaniasis resistance 3b (mouse)55960280193602980Mouse
11040591Lmr3c_mleishmaniasis resistance 3c (mouse)55960280193602980Mouse
12904739M2fscn2_mmodifier 2 of FSCN2 (mouse)566529661100529661Mouse
1301243Bmd2_mbone mineral density 2 (mouse)Not determined555388334100455525Mouse
13207584Mwmlpt4_mMorris water maze latency to platform, training, 4 (mouse)54632260680322606Mouse
11041665Lmr24_mleishmaniasis resistance 24 (mouse)552694462107321041Mouse
13207588Mwmlpa4_mMorris water maze latency to platform, all, 4 (mouse)54632260680322606Mouse
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5889069387841837Mouse
4141647Hrvhf1_mheart rate variability, high frequency 1 (mouse)Not determined3643342370433423Mouse
11049560Lmr24d_mleishmaniasis resistance 24d (mouse)56437487798374996Mouse
11049561Lmr24e_mleishmaniasis resistance 24e (mouse)53569446269694594Mouse
13464252Ahl10_mage related hearing loss, early onset 10 (mouse)53585456869854714Mouse
1301223Hdlq7_mHDL QTL 7 (mouse)Not determined53585456869854714Mouse
13464248Ahl13_mage related hearing loss, early onset 13 (mouse)55564587489645995Mouse
11252124Modvl6_mmodifier of vacuolated lens 6 (mouse)56265056896650688Mouse
13464250Ahl15_mage related hearing loss, early onset 15 (mouse)56265056896650688Mouse
13464245Ahl12_mage related hearing loss, early onset 12 (mouse)53811168172111798Mouse
11040592Lmr3d_mleishmaniasis resistance 3d (mouse)55960280193602980Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
13464247Ahl14_mage related hearing loss, early onset 14 (mouse)56040306294403160Mouse
13464246Ahl11_mage related hearing loss, early onset 11 (mouse)53764377771643896Mouse
10044005Ahl7_mage related hearing loss 7 (mouse)Not determined55833050292330641Mouse
11049558Lmr24b_mleishmaniasis resistance 24b (mouse)53569446269694594Mouse
11049559Lmr24c_mleishmaniasis resistance 24c (mouse)53569446269694594Mouse

Markers in Region
C88048  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38566,687,000 - 66,687,216UniSTSGRCm38
MGSCv37567,078,239 - 67,078,455UniSTSGRCm37
Celera563,987,680 - 63,987,896UniSTS
Cytogenetic Map5C3.1UniSTS
Whitehead/MRC_RH5962.84UniSTS
RH128109  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38566,687,016 - 66,687,193UniSTSGRCm38
MGSCv37567,078,255 - 67,078,432UniSTSGRCm37
Celera563,987,696 - 63,987,873UniSTS
Cytogenetic Map5C3.1UniSTS
Uchl1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5C3.1UniSTS
cM Map536.0UniSTS
RH125268  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38566,687,092 - 66,687,180UniSTSGRCm38
MGSCv37567,078,331 - 67,078,419UniSTSGRCm37
Celera563,987,772 - 63,987,860UniSTS
Cytogenetic Map5C3.1UniSTS
Uchl1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5C3.1UniSTS
Uchl1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5C3.1UniSTS
cM Map536.0UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000031131   ⟹   ENSMUSP00000031131
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl566,833,434 - 66,844,577 (+)Ensembl
GRCm38.p6 Ensembl566,676,091 - 66,687,234 (+)Ensembl
Ensembl Acc Id: ENSMUST00000176015
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl566,834,235 - 66,844,572 (+)Ensembl
GRCm38.p6 Ensembl566,676,892 - 66,687,229 (+)Ensembl
Ensembl Acc Id: ENSMUST00000177194
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl566,833,585 - 66,834,188 (+)Ensembl
GRCm38.p6 Ensembl566,676,242 - 66,676,845 (+)Ensembl
Ensembl Acc Id: ENSMUST00000202339
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl566,841,027 - 66,844,281 (+)Ensembl
GRCm38.p6 Ensembl566,683,684 - 66,686,938 (+)Ensembl
RefSeq Acc Id: NM_011670   ⟹   NP_035800
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39566,833,464 - 66,844,577 (+)NCBI
GRCm38566,676,121 - 66,687,234 (+)ENTREZGENE
MGSCv37567,067,360 - 67,078,473 (+)RGD
Celera563,976,841 - 63,987,914 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_035800   ⟸   NM_011670
- UniProtKB: Q9R122 (UniProtKB/Swiss-Prot),   Q9R0P9 (UniProtKB/Swiss-Prot),   Q3TCH2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000031131   ⟸   ENSMUST00000031131
Protein Domains
UCH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R0P9-F1-model_v2 AlphaFold Q9R0P9 1-223 view protein structure

Promoters
RGD ID:6886808
Promoter ID:EPDNEW_M6855
Type:multiple initiation site
Name:Uchl1_1
Description:Mus musculus ubiquitin carboxy-terminal hydrolase L1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38566,676,243 - 66,676,303EPDNEW
RGD ID:6838575
Promoter ID:MM_KWN:42439
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   MEF_B4,   MEF_B6
Transcripts:NM_011670
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36567,067,254 - 67,067,754 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:103149 AgrOrtholog
Ensembl Genes ENSMUSG00000029223 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000031131 ENTREZGENE
  ENSMUST00000031131.11 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.532.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C12_UCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C12_UCH_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22223 UniProtKB/Swiss-Prot
MGD MGI:103149 ENTREZGENE
NCBI Gene 22223 ENTREZGENE
PANTHER PTHR10589 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10589:SF19 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Peptidase_C12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Uchl1 PhenoGen
PRINTS UBCTHYDRLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE UCH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt I7ENE7_MOUSE UniProtKB/TrEMBL
  Q3TCH2 ENTREZGENE, UniProtKB/TrEMBL
  Q9R0P9 ENTREZGENE
  Q9R122 ENTREZGENE
  UCHL1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q9R122 UniProtKB/Swiss-Prot