Hfe (homeostatic iron regulator) - Rat Genome Database

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Gene: Hfe (homeostatic iron regulator) Mus musculus
Analyze
Symbol: Hfe
Name: homeostatic iron regulator
RGD ID: 736272
MGI Page MGI
Description: Enables transferrin receptor binding activity. Involved in positive regulation of gene expression. Acts upstream of or within hormone biosynthetic process and multicellular organismal-level iron ion homeostasis. Part of HFE-transferrin receptor complex. Is expressed in brain; choroid invagination; diencephalon roof plate; medulla oblongata part of 4th ventricle choroid plexus; and metencephalon part of 4th ventricle choroid plexus. Used to study hemochromatosis type 1. Human ortholog(s) of this gene implicated in several diseases, including acute porphyria (multiple); arthritis (multiple); bone marrow cancer (multiple); hemochromatosis (multiple); and liver disease (multiple). Orthologous to human HFE (homeostatic iron regulator).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hemochromatosis; hereditary hemochromatosis protein homolog; MGC151121; MGC151123; MR; MR2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391323,886,017 - 23,894,837 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1323,886,017 - 23,894,837 (-)EnsemblGRCm39 Ensembl
GRCm381323,702,034 - 23,710,854 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1323,702,034 - 23,710,854 (-)EnsemblGRCm38mm10GRCm38
MGSCv371323,795,710 - 23,802,680 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361323,711,306 - 23,718,276 (-)NCBIMGSCv36mm8
Celera1323,935,174 - 23,942,163 (-)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map139.88NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Abdominal Pain  (ISO)
acute lymphoblastic leukemia  (ISO)
Alcoholic Liver Diseases  (ISO)
Alzheimer's disease  (ISO)
Alzheimer's disease 1  (ISO)
aphthous stomatitis  (ISO)
autism spectrum disorder  (ISO)
beta thalassemia  (ISO)
Birth Weight  (ISO)
breast cancer  (ISO)
Cardiomegaly  (IMP)
cardiomyopathy  (ISO)
carotid artery disease  (ISO)
Chronic Pain  (ISO)
colorectal cancer  (ISO)
coronary artery disease  (ISO)
Crohn's disease  (ISO)
cystic fibrosis  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
fatty liver disease  (ISO)
genetic disease  (ISO)
hemochromatosis  (IMP,ISO)
hemochromatosis type 1  (IAGP,ISO)
hemochromatosis type 2  (ISO)
hepatic veno-occlusive disease  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
intestinal obstruction  (ISO)
iron deficiency anemia  (ISO)
Iron Overload  (ISO)
juvenile rheumatoid arthritis  (ISO)
Lead Poisoning  (ISO)
liver cirrhosis  (ISO)
liver disease  (ISO)
Meconium Ileus  (ISO)
multiple myeloma  (ISO)
myelodysplastic syndrome  (ISO)
myelofibrosis  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Nervous System Malformations  (ISO)
neuropathy  (ISO)
non-alcoholic fatty liver disease  (ISO)
obesity  (ISO)
osteoarthritis  (ISO)
Osteoarthritis, Hip  (ISO)
osteoporosis  (IMP)
ovarian cancer  (ISO)
Pain  (ISO)
Parkinson's disease  (ISO)
peripheral nervous system disease  (ISO)
peripheral vascular disease  (ISO)
polycythemia vera  (ISO)
polymyalgia rheumatica  (ISO)
porphyria  (ISO)
porphyria cutanea tarda  (IMP,ISO)
Presenile and Senile Dementia  (ISO)
Refractory Anemia  (ISO)
retinal degeneration  (IMP)
rheumatoid arthritis  (ISO)
Sarcopenia  (ISO)
type 2 diabetes mellitus  (ISO)
Varicose Ulcer  (ISO)
variegate porphyria  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP)
bisphenol A  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
ceric oxide  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
didanosine  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
genistein  (EXP)
gentamycin  (ISO)
glutathione  (ISO)
hydralazine  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
iron atom  (EXP,ISO)
iron(0)  (EXP,ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
N-ethyl-N-nitrosourea  (EXP)
nefazodone  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (ISO)
propiconazole  (EXP)
rotenone  (ISO)
silicon dioxide  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP,ISO)
stavudine  (ISO)
succimer  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
torcetrapib  (ISO)
triadimefon  (EXP)
valproic acid  (ISO)
zinc atom  (EXP)
zinc protoporphyrin  (ISO)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (ISO)
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent  (IBA)
antigen processing and presentation of endogenous peptide antigen via MHC class Ib  (IBA)
BMP signaling pathway  (ISO)
cellular response to iron ion  (ISO)
cellular response to iron ion starvation  (ISO)
female pregnancy  (ISO)
hormone biosynthetic process  (IMP)
intracellular iron ion homeostasis  (ISO)
iron ion transmembrane transport  (IEA)
liver regeneration  (ISO)
monoatomic ion transport  (IEA)
multicellular organismal-level iron ion homeostasis  (IMP,ISO)
negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I  (ISO)
negative regulation of CD8-positive, alpha-beta T cell activation  (ISO)
negative regulation of proteasomal ubiquitin-dependent protein catabolic process  (IC)
negative regulation of receptor binding  (ISO)
negative regulation of signaling receptor activity  (ISO)
negative regulation of T cell cytokine production  (ISO)
negative regulation of ubiquitin-dependent protein catabolic process  (IC,ISO)
obsolete iron ion homeostasis  (ISO)
positive regulation of ferrous iron binding  (ISO)
positive regulation of gene expression  (IMP)
positive regulation of pathway-restricted SMAD protein phosphorylation  (ISO)
positive regulation of peptide hormone secretion  (ISO)
positive regulation of protein binding  (ISO)
positive regulation of receptor binding  (ISO)
positive regulation of receptor-mediated endocytosis  (ISO)
positive regulation of signaling receptor activity  (ISO)
positive regulation of T cell mediated cytotoxicity  (IBA)
positive regulation of transferrin receptor binding  (ISO)
regulation of iron ion transport  (IBA,ISO)
regulation of protein localization to cell surface  (ISO)
response to iron ion  (ISO)
response to iron ion starvation  (IBA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Investigation of genetic variants of genes of the hemochromatosis pathway and their role in breast cancer. Abraham BK, etal., Cancer Epidemiol Biomarkers Prev. 2005 May;14(5):1102-7.
2. HFE C282Y mutation as a genetic modifier influencing disease susceptibility for chronic myeloproliferative disease. Andrikovics H, etal., Cancer Epidemiol Biomarkers Prev. 2009 Mar;18(3):929-34. doi: 10.1158/1055-9965.EPI-08-0359. Epub 2009 Mar 3.
3. Common variable immunodeficiency and IgG subclass deficiency in central Alabama hemochromatosis probands homozygous for HFE C282Y. Barton JC, etal., Blood Cells Mol Dis. 2003 Jul-Aug;31(1):102-11.
4. Genotypic and phenotypic heterogeneity of African Americans with primary iron overload. Barton JC, etal., Blood Cells Mol Dis. 2003 Nov-Dec;31(3):310-9.
5. Interaction between haemochromatosis and transferrin receptor genes in different neoplastic disorders. Beckman LE, etal., Carcinogenesis. 1999 Jul;20(7):1231-3.
6. Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma. Bugianesi E, etal., Gastroenterology. 2002 Jul;123(1):134-40.
7. Association between HFE mutations and acute myocardial infarction: a study in patients from Northern and Southern Italy. Candore G, etal., Blood Cells Mol Dis. 2003 Jul-Aug;31(1):57-62.
8. Mutation H63D in the HFE gene confers risk for the development of type 2 diabetes mellitus but not for chronic complications. Colli ML, etal., J Diabetes Complications. 2011 Jan-Feb;25(1):25-30. doi: 10.1016/j.jdiacomp.2009.12.002. Epub 2010 Jan 25.
9. Porphyria cutanea tarda, hepatitis C, uroporphyrinogen decarboxylase and mutations of HFE gene. A case-control study. Cribier B, etal., Dermatology. 2009;218(1):15-21. doi: 10.1159/000173696. Epub 2008 Nov 12.
10. An extensive analysis of the hereditary hemochromatosis gene HFE and neighboring histone genes: associations with childhood leukemia. Davis CF and Dorak MT, Ann Hematol. 2010 Apr;89(4):375-84. doi: 10.1007/s00277-009-0839-y. Epub 2009 Oct 6.
11. The role of TMPRSS6 and HFE variants in iron deficiency anemia in celiac disease. De Falco L, etal., Am J Hematol. 2018 Mar;93(3):383-393. doi: 10.1002/ajh.24991. Epub 2017 Dec 18.
12. Iron-dependent regulation of MDM2 influences p53 activity and hepatic carcinogenesis. Dongiovanni P, etal., Am J Pathol. 2010 Feb;176(2):1006-17. Epub 2009 Dec 17.
13. The C282Y mutation of HFE is another male-specific risk factor for childhood acute lymphoblastic leukemia. Dorak MT, etal., Blood. 1999 Dec 1;94(11):3957.
14. Decreased Bone Formation Explains Osteoporosis in a Genetic Mouse Model of Hemochromatosiss. Doyard M, etal., PLoS One. 2016 Feb 1;11(2):e0148292. doi: 10.1371/journal.pone.0148292. eCollection 2016.
15. Clinical characteristics of type 2 diabetes in patients with mutations of HFE. Dubois-Laforgue D, etal., Diabetes Metab. 2000 Feb;26(1):65-8.
16. Beyond Human Leukocyte Antigen Class I Antigens: Hereditary Hemochromatosis Gene Mutations in Recurrent Aphthous Oral Ulcers and Behçet Disease in the South of Tunisia. ElAoud S, etal., Med Princ Pract. 2017;26(5):427-432. doi: 10.1159/000481782. Epub 2017 Sep 26.
17. The D519G Polymorphism of Glyceronephosphate O-Acyltransferase Is a Risk Factor for Familial Porphyria Cutanea Tarda. Farrell CP, etal., PLoS One. 2016 Sep 23;11(9):e0163322. doi: 10.1371/journal.pone.0163322. eCollection 2016.
18. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Feder JN, etal., Nat Genet. 1996 Aug;13(4):399-408.
19. Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis. George DK, etal., Gastroenterology. 1998 Feb;114(2):311-8.
20. Absence of iron-regulatory protein Hfe results in hyperproliferation of retinal pigment epithelium: role of cystine/glutamate exchanger. Gnana-Prakasam JP, etal., Biochem J. 2009 Nov 11;424(2):243-52. doi: 10.1042/BJ20090424.
21. Frequency of HFE gene mutations in Iranian beta-thalassaemia minor patients. Jazayeri M, etal., Eur J Haematol. 2003 Dec;71(6):408-11.
22. Association of HFE gene C282Y and H63D mutations with liver cirrhosis in the Lithuanian population. Juzėnas S, etal., Medicina (Kaunas). 2016;52(5):269-275. doi: 10.1016/j.medici.2016.09.004. Epub 2016 Oct 3.
23. The hemochromatosis C282Y allele: a risk factor for hepatic veno-occlusive disease after hematopoietic stem cell transplantation. Kallianpur AR, etal., Bone Marrow Transplant. 2005 Jun;35(12):1155-64.
24. Increased prevalence of the HFE C282Y hemochromatosis allele in women with breast cancer. Kallianpur AR, etal., Cancer Epidemiol Biomarkers Prev. 2004 Feb;13(2):205-12.
25. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
26. Frequency of hemochromatosis gene (HFE) mutations in Russian healthy women and patients with estrogen-dependent cancers. Kondrashova TV, etal., Biochim Biophys Acta. 2006 Jan;1762(1):59-65. Epub 2005 Sep 23.
27. Hemochromatosis gene (HFE) polymorphisms are not associated with peripheral arterial disease. Koppel H, etal., Thromb Haemost. 2004 Jun;91(6):1258-9.
28. Long-term sequelae of HFE deletion in C57BL/6 x 129/O1a mice, an animal model for hereditary haemochromatosis. Lebeau A, etal., Eur J Clin Invest. 2002 Aug;32(8):603-12.
29. Transcriptome Analysis of Acute Phase Liver Graft Injury in Liver Transplantation. Lee NP, etal., Biomedicines. 2018 Apr 6;6(2). pii: biomedicines6020041. doi: 10.3390/biomedicines6020041.
30. Impact of hemochromatosis gene mutations on cardiac status in doxorubicin-treated survivors of childhood high-risk leukemia. Lipshultz SE, etal., Cancer. 2013 Oct 1;119(19):3555-62. doi: 10.1002/cncr.28256. Epub 2013 Jul 16.
31. Haemochromatosis gene mutations in idiopathic dilated cardiomyopathy. Mahon NG, etal., Heart. 2000 Nov;84(5):541-7.
32. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Marchesini G, etal., Diabetes. 2001 Aug;50(8):1844-50.
33. H63D mutation in the HFE gene increases iron overload in beta-thalassemia carriers. Melis MA, etal., Haematologica. 2002 Mar;87(3):242-5.
34. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
35. MGDs mouse GO annotations MGD data from the GO Consortium
36. MGD IEA MGD IEA
37. HFE mutations analysis in 711 hemochromatosis probands: evidence for S65C implication in mild form of hemochromatosis. Mura C, etal., Blood. 1999 Apr 15;93(8):2502-5.
38. Hemochromatosis-associated gene mutations in patients with myelodysplastic syndromes with refractory anemia with ringed sideroblasts. Nearman ZP, etal., Am J Hematol. 2007 Dec;82(12):1076-9.
39. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
40. The HFE gene is associated to an earlier age of onset and to the presence of diabetic nephropathy in diabetes mellitus type 2. Oliva R, etal., Endocrine. 2004 Jul;24(2):111-4.
41. HFE gene mutations in Brazilian thalassemic patients. Oliveira TM, etal., Braz J Med Biol Res. 2006 Dec;39(12):1575-80.
42. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
43. Hemochromatosis gene variants in patients with cardiomyopathy. Pereira AC, etal., Am J Cardiol. 2001 Aug 15;88(4):388-91.
44. A mouse model of familial porphyria cutanea tarda. Phillips JD, etal., Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):259-64.
45. Common conditions associated with hereditary haemochromatosis genetic variants: cohort study in UK Biobank. Pilling LC, etal., BMJ. 2019 Jan 16;364:k5222. doi: 10.1136/bmj.k5222.
46. [Mutations in the HFE gene in patients with rheumatic diseases]. Putova I, etal., Cas Lek Cesk. 2005;144(6):391-7; discussion 397-8.
47. Transferrin Level Before Treatment and Genetic Polymorphism in HFE Gene as Predictive Markers for Response to Adalimumab in Crohn's Disease Patients. Repnik K, etal., Biochem Genet. 2016 Aug;54(4):476-486. doi: 10.1007/s10528-016-9734-0. Epub 2016 Apr 26.
48. Mouse MP Annotation Import Pipeline RGD automated import pipeline
49. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
50. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
51. Synergy between the C2 allele of transferrin and the C282Y allele of the haemochromatosis gene (HFE) as risk factors for developing Alzheimer's disease. Robson KJ, etal., J Med Genet 2004 Apr;41(4):261-5.
52. Cloning, sequencing and characterization of the rat hereditary hemochromatosis promoter: comparison of the human, mouse and rat HFE promoter regions. Sanchez M, etal., Gene 1998 Dec 28;225(1-2):77-87.
53. Glutathione S-transferase (GST) polymorphisms as risk factors for cancer in a highly homogeneous population from southern Italy. Sgambato A, etal., Anticancer Res. 2002 Nov-Dec;22(6B):3647-52.
54. Mutations in the HFE gene can be associated with increased lung disease severity in cystic fibrosis. Smith DJ, etal., Gene. 2019 Jan 30;683:12-17. doi: 10.1016/j.gene.2018.10.002. Epub 2018 Oct 3.
55. Iron overload exacerbates age-associated cardiac hypertrophy in a mouse model of hemochromatosis. Sukumaran A, etal., Sci Rep. 2017 Jul 18;7(1):5756. doi: 10.1038/s41598-017-05810-2.
56. Haemochromatosis (HFE) gene C282Y mutation and the risk of coronary artery disease and myocardial infarction: a study in 1279 patients undergoing coronary angiography. Surber R, etal., J Med Genet. 2003 May;40(5):e58.
57. Hereditary Hemochromatosis Associations with Frailty, Sarcopenia and Chronic Pain: Evidence from 200,975 Older UK Biobank Participants. Tamosauskaite J, etal., J Gerontol A Biol Sci Med Sci. 2019 Feb 15;74(3):337-342. doi: 10.1093/gerona/gly270.
58. The C282Y mutation of the HFE gene is not found in Chinese haemochromatotic patients: multicentre retrospective study. Tsui WM, etal., Hong Kong Med J. 2000 Jun;6(2):153-8.
59. Increased risk of acute myocardial infarction in carriers of the hemochromatosis gene Cys282Tyr mutation : a prospective cohort study in men in eastern Finland. Tuomainen TP, etal., Circulation. 1999 Sep 21;100(12):1274-9.
60. High incidence of hemochromatosis gene mutations in the myelodysplastic syndrome: the Budapest Study on 50 patients. Varkonyi J, etal., Acta Haematol. 2003;109(2):64-7.
61. HFE gene mutations in patients with acute leukemia. Viola A, etal., Leuk Lymphoma. 2006 Nov;47(11):2331-4.
62. [Mutations of hemochromatosis gene in volunteer blood donors and Chilean porphyria cutanea tarda patients]. Wolff CF, etal., Medicina (B Aires). 2006;66(5):421-6.
63. Hepatic macrophage iron aggravates experimental alcoholic steatohepatitis. Xiong S, etal., Am J Physiol Gastrointest Liver Physiol. 2008 Sep;295(3):G512-21. doi: 10.1152/ajpgi.90327.2008. Epub 2008 Jul 3.
64. The effect of iron status on vascular health. Yunker LM, etal., Vasc Med. 2006 May;11(2):85-91.
65. The overlapping of local iron overload and HFE mutation in venous leg ulcer pathogenesis. Zamboni P, etal., Free Radic Biol Med. 2006 May 15;40(10):1869-73. Epub 2006 Feb 14.
66. Hemochromatosis C282Y gene mutation increases the risk of venous leg ulceration. Zamboni P, etal., J Vasc Surg. 2005 Aug;42(2):309-14.
Additional References at PubMed
PMID:8889548   PMID:9020055   PMID:9396865   PMID:9482913   PMID:9486091   PMID:9548560   PMID:10077651   PMID:10081226   PMID:10349636   PMID:10381492   PMID:10557317   PMID:10681454  
PMID:10791995   PMID:11042159   PMID:11076861   PMID:11159549   PMID:11226304   PMID:11313312   PMID:11340100   PMID:11358357   PMID:11641716   PMID:11875007   PMID:11943867   PMID:12149232  
PMID:12297827   PMID:12367579   PMID:12468424   PMID:12477932   PMID:12540785   PMID:12547226   PMID:12631660   PMID:12704388   PMID:12704390   PMID:12706501   PMID:12750309   PMID:12805055  
PMID:12880182   PMID:14510961   PMID:14610273   PMID:14618243   PMID:14656876   PMID:14656877   PMID:14673107   PMID:15098034   PMID:15131800   PMID:15155457   PMID:15192150   PMID:15257718  
PMID:15308612   PMID:15319276   PMID:15382179   PMID:15389541   PMID:15613548   PMID:15684062   PMID:15718038   PMID:15782199   PMID:15849611   PMID:15866286   PMID:15914561   PMID:16123136  
PMID:16141072   PMID:16141073   PMID:16239432   PMID:16339398   PMID:16491649   PMID:16565419   PMID:16688533   PMID:16893896   PMID:17003411   PMID:17062627   PMID:17064691   PMID:17116709  
PMID:17207112   PMID:17255318   PMID:17258727   PMID:17264297   PMID:17293870   PMID:17376729   PMID:17495347   PMID:17971451   PMID:18042040   PMID:18249176   PMID:18316026   PMID:18367482  
PMID:18393371   PMID:18684963   PMID:18694968   PMID:19254567   PMID:19348938   PMID:19426170   PMID:19591830   PMID:19622835   PMID:19700664   PMID:19787063   PMID:19809161   PMID:19824072  
PMID:20060900   PMID:20110460   PMID:20177050   PMID:20338170   PMID:20530874   PMID:20634490   PMID:20837779   PMID:20876715   PMID:20976594   PMID:21059897   PMID:21245482   PMID:21267068  
PMID:21349849   PMID:21355094   PMID:21364282   PMID:21408141   PMID:21677750   PMID:21817060   PMID:21873635   PMID:22058337   PMID:22244935   PMID:22370144   PMID:22383097   PMID:22466002  
PMID:22496346   PMID:22497726   PMID:22531912   PMID:22745741   PMID:22858058   PMID:22960056   PMID:22996660   PMID:23169885   PMID:23223430   PMID:23429074   PMID:23524968   PMID:23705020  
PMID:24126888   PMID:24155934   PMID:24439478   PMID:24685134   PMID:24904118   PMID:24952961   PMID:25283820   PMID:25427953   PMID:25608116   PMID:25609138   PMID:25880808   PMID:26028554  
PMID:26301810   PMID:26660104   PMID:26707700   PMID:26835538   PMID:27295312   PMID:27354540   PMID:27741349   PMID:27796299   PMID:28350201   PMID:28378742   PMID:28558946   PMID:28784700  
PMID:28864822   PMID:29315562   PMID:29445185   PMID:30277817   PMID:30427936   PMID:31132316   PMID:31188032   PMID:31298936   PMID:31339576   PMID:31442254   PMID:31717526   PMID:32019729  
PMID:32083318   PMID:32108988   PMID:32227235   PMID:32239172   PMID:32380257   PMID:32574378   PMID:32746697   PMID:32861780   PMID:32955078   PMID:33054105   PMID:33148716   PMID:33839281  
PMID:34855211   PMID:34995689   PMID:35359834   PMID:36064805   PMID:36322932  


Genomics

Comparative Map Data
Hfe
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391323,886,017 - 23,894,837 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1323,886,017 - 23,894,837 (-)EnsemblGRCm39 Ensembl
GRCm381323,702,034 - 23,710,854 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1323,702,034 - 23,710,854 (-)EnsemblGRCm38mm10GRCm38
MGSCv371323,795,710 - 23,802,680 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361323,711,306 - 23,718,276 (-)NCBIMGSCv36mm8
Celera1323,935,174 - 23,942,163 (-)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map139.88NCBI
HFE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38626,087,429 - 26,098,343 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl626,087,281 - 26,098,343 (+)EnsemblGRCh38hg38GRCh38
GRCh37626,087,657 - 26,098,571 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36626,195,427 - 26,205,038 (+)NCBINCBI36Build 36hg18NCBI36
Build 34626,195,487 - 26,202,575NCBI
Celera627,316,734 - 27,326,343 (+)NCBICelera
Cytogenetic Map6p22.2NCBI
HuRef626,030,572 - 26,038,529 (+)NCBIHuRef
CHM1_1626,089,764 - 26,097,723 (+)NCBICHM1_1
T2T-CHM13v2.0625,955,571 - 25,966,491 (+)NCBIT2T-CHM13v2.0
Hfe
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21741,413,451 - 41,421,502 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1741,413,451 - 41,421,502 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1741,489,877 - 41,497,957 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01743,093,927 - 43,102,007 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01741,372,593 - 41,380,657 (+)NCBIRnor_WKY
Rnor_6.01743,661,276 - 43,669,327 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1743,661,222 - 43,669,985 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01745,515,737 - 45,523,531 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41748,469,927 - 48,478,502 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X40,352,010 - 40,353,825 (-)NCBI
Celera1741,045,860 - 41,053,914 (+)NCBICelera
Cytogenetic Map17p11NCBI
Hfe
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955483932,352 - 941,143 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955483933,269 - 941,070 (-)NCBIChiLan1.0ChiLan1.0
HFE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1626,580,358 - 26,588,591 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl626,580,358 - 26,588,591 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0625,921,663 - 25,930,852 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
HFE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13524,031,479 - 24,038,922 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3524,031,387 - 24,042,413 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3523,909,830 - 23,917,616 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03524,146,456 - 24,154,001 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3524,146,471 - 24,153,996 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13523,962,739 - 23,970,249 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03524,013,776 - 24,021,305 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03525,446,369 - 25,453,909 (+)NCBIUU_Cfam_GSD_1.0
Hfe
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049461,673,979 - 1,681,465 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366711,940,101 - 1,947,580 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366711,940,079 - 1,947,574 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HFE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl720,758,741 - 20,767,000 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1720,758,604 - 20,767,004 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HFE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11746,159,770 - 46,168,831 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1746,156,685 - 46,164,649 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604426,023,513 - 26,034,665 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hfe
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624756823,947 - 831,376 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624756821,738 - 831,482 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2659
Count of miRNA genes:758
Interacting mature miRNAs:979
Transcripts:ENSMUST00000006787, ENSMUST00000091706, ENSMUST00000091707, ENSMUST00000151243
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301255Cd4ts6_mCD4 T cell subset 6 (mouse)Not determined1316854534168684Mouse
10449140Eosn2_meosinophil differential 2 (mouse)1322131134221311Mouse
15039338Nmrs34_mNAFLD-associated magnetic resonance shift 34 (mouse)1322131134221311Mouse
1301455Bmd3_mbone mineral density 3 (mouse)Not determined13347761237477820Mouse
10045624Heal24_mwound healing/regeneration (mouse)Not determined13347761237477820Mouse
10045625Heal23_mwound healing/regeneration 23 (mouse)Not determined13347761237477820Mouse
1301367Twq1_mtestis weight QTL 1 (mouse)Not determined13361551237615672Mouse
1301733Heal3_mwound healing/regeneration 3 (mouse)Not determined13368020037680343Mouse
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
1558898Hpi1_mhapatic PMN infiltration 1 (mouse)Not determined13441402553101640Mouse
10402494Igmsc1_mimmunoglobulin M secreting cells 1 (mouse)Not determined131716854544918560Mouse
1301984Pbd2_mpeak bone density 2 (mouse)Not determined131718950838947406Mouse
1301880Hypt_mhypertension (mouse)Not determined131815679252156924Mouse
13463469Gssq1_mglomerulosclerosis severity QTL 1 (mouse)131906090853061050Mouse
12880423V25Dq7_mvitamin D inactive form serum level QTL 7 (mouse)131958398353583983Mouse
1301015Sysbp2_msystolic blood pressure 2 (mouse)Not determined132047761259821605Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
1357591Tesq1_mtestis weight QTL 1 (mouse)Not determined132061551255720517Mouse
4142009Pregq3_mpregnancy QTL 3 (mouse)Not determined132061551272385189Mouse
10045618Heal17_mwound healing/regeneration 17 (mouse)Not determined132074693954747056Mouse

Markers in Region
RH142147  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381323,705,040 - 23,705,233UniSTSGRCm38
MGSCv371323,796,909 - 23,797,102UniSTSGRCm37
Celera1323,936,372 - 23,936,583UniSTS
Cytogenetic Map13A2-A4UniSTS
U66849  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381323,704,263 - 23,704,396UniSTSGRCm38
MGSCv371323,796,132 - 23,796,265UniSTSGRCm37
Celera1323,935,596 - 23,935,729UniSTS
Cytogenetic Map13A2-A4UniSTS
Whitehead/MRC_RH13280.73UniSTS
PMC23944P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381323,708,886 - 23,709,218UniSTSGRCm38
MGSCv371323,800,755 - 23,801,087UniSTSGRCm37
Celera1323,940,238 - 23,940,570UniSTS
Cytogenetic Map13A2-A4UniSTS
PMC315447P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381323,706,108 - 23,706,307UniSTSGRCm38
MGSCv371323,797,977 - 23,798,176UniSTSGRCm37
Celera1323,937,458 - 23,937,659UniSTS
Cytogenetic Map13A2-A4UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001347493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006516556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF007558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ298838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ306425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK009581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK220051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL590388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL592149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY870803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY870804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY870805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY880964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY880965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY880966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY880967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY880968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY880969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY880970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY880971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY880972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY880973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY880974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY880975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY880976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY880977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY880978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY880979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY880980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY880981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY880982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY880983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY907046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY907047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC116744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC116746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE995172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY198206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U66849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U80604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y12650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000006787   ⟹   ENSMUSP00000006787
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1323,888,369 - 23,894,697 (-)Ensembl
GRCm38.p6 Ensembl1323,704,386 - 23,710,714 (-)Ensembl
RefSeq Acc Id: ENSMUST00000091706   ⟹   ENSMUSP00000089298
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1323,886,017 - 23,894,837 (-)Ensembl
GRCm38.p6 Ensembl1323,702,034 - 23,710,854 (-)Ensembl
RefSeq Acc Id: ENSMUST00000091707   ⟹   ENSMUSP00000089299
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1323,888,369 - 23,894,697 (-)Ensembl
GRCm38.p6 Ensembl1323,704,386 - 23,710,714 (-)Ensembl
RefSeq Acc Id: ENSMUST00000151243   ⟹   ENSMUSP00000116569
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1323,886,017 - 23,889,671 (-)Ensembl
GRCm38.p6 Ensembl1323,702,034 - 23,705,688 (-)Ensembl
RefSeq Acc Id: NM_001347493   ⟹   NP_001334422
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391323,886,017 - 23,894,837 (-)NCBI
GRCm381323,702,034 - 23,710,854 (-)NCBI
Sequence:
RefSeq Acc Id: NM_010424   ⟹   NP_034554
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391323,886,017 - 23,894,837 (-)NCBI
GRCm381323,702,034 - 23,710,854 (-)NCBI
MGSCv371323,795,710 - 23,802,680 (-)RGD
Celera1323,935,174 - 23,942,163 (-)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006516556   ⟹   XP_006516619
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391323,886,713 - 23,894,776 (-)NCBI
GRCm381323,702,730 - 23,710,625 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034554   ⟸   NM_010424
- Peptide Label: isoform a precursor
- UniProtKB: Q9D754 (UniProtKB/Swiss-Prot),   P70387 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006516619   ⟸   XM_006516556
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001334422   ⟸   NM_001347493
- Peptide Label: isoform b precursor
- UniProtKB: P70387 (UniProtKB/Swiss-Prot),   Q5SZ87 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000089298   ⟸   ENSMUST00000091706
RefSeq Acc Id: ENSMUSP00000089299   ⟸   ENSMUST00000091707
RefSeq Acc Id: ENSMUSP00000006787   ⟸   ENSMUST00000006787
RefSeq Acc Id: ENSMUSP00000116569   ⟸   ENSMUST00000151243
Protein Domains
Ig-like   Ig-like C1-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70387-F1-model_v2 AlphaFold P70387 1-359 view protein structure

Promoters
RGD ID:8679828
Promoter ID:EPDNEW_M17945
Type:initiation region
Name:Hfe_1
Description:Mus musculus hemochromatosis , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381323,710,809 - 23,710,869EPDNEW
RGD ID:6824010
Promoter ID:MM_KWN:13533
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Lung,   Spleen
Transcripts:ENSMUST00000006787,   ENSMUST00000091707,   ENSMUST00000095678,   OTTMUST00000001384
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361323,802,421 - 23,803,467 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109191 AgrOrtholog
Ensembl Genes ENSMUSG00000006611 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000006787.8 UniProtKB/TrEMBL
  ENSMUSP00000089298 ENTREZGENE
  ENSMUSP00000089298.7 UniProtKB/Swiss-Prot
  ENSMUSP00000089299 ENTREZGENE
  ENSMUSP00000089299.7 UniProtKB/TrEMBL
  ENSMUSP00000116569.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000006787.8 UniProtKB/TrEMBL
  ENSMUST00000091706 ENTREZGENE
  ENSMUST00000091706.14 UniProtKB/Swiss-Prot
  ENSMUST00000091707 ENTREZGENE
  ENSMUST00000091707.13 UniProtKB/TrEMBL
  ENSMUST00000151243.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.500.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig/MHC_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_C1-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHC_I-like_Ag-recog UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHC_I-like_Ag-recog_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHC_I/II-like_Ag-recog UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHC_I_a_a1/a2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15216 UniProtKB/Swiss-Prot
MGD MGI:109191 ENTREZGENE
NCBI Gene 15216 ENTREZGENE
PANTHER MHC CLASS I-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR16675:SF172 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam C1-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHC_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB HFE RGD
PhenoGen Hfe PhenoGen
PRINTS MHCCLASSI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IG_MHC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGc1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54452 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F7CW53_MOUSE UniProtKB/TrEMBL
  HFE_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q5SZ87 ENTREZGENE, UniProtKB/TrEMBL
  Q5SZ91_MOUSE UniProtKB/TrEMBL
  Q8R557_MOUSE UniProtKB/TrEMBL
  Q9D754 ENTREZGENE
UniProt Secondary Q14AQ5 UniProtKB/Swiss-Prot
  Q5SZ90 UniProtKB/Swiss-Prot
  Q9D754 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-26 Hfe  homeostatic iron regulator    hemochromatosis  Symbol and/or name change 5135510 APPROVED