Meox2 (mesenchyme homeobox 2) - Rat Genome Database

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Gene: Meox2 (mesenchyme homeobox 2) Mus musculus
Analyze
Symbol: Meox2
Name: mesenchyme homeobox 2
RGD ID: 736210
MGI Page MGI
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including angiogenesis; skeletal muscle tissue development; and somite specification. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; heart; and musculoskeletal system. Orthologous to human MEOX2 (mesenchyme homeobox 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI528662; Ga; Gax; growth arrest-specific homeobox; homeobox protein MOX-2; Mox; Mox-; Mox-2; Mox2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391237,158,539 - 37,229,533 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1237,158,539 - 37,229,533 (+)EnsemblGRCm39 Ensembl
GRCm381237,108,540 - 37,179,534 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1237,108,540 - 37,179,534 (+)EnsemblGRCm38mm10GRCm38
MGSCv371237,835,133 - 37,906,115 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361237,618,812 - 37,689,794 (+)NCBIMGSCv36mm8
Celera1238,548,347 - 38,608,374 (+)NCBICelera
Cytogenetic Map12A3NCBI
cM Map1216.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,7-dihydropurine-6-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
chloroprene  (EXP)
chlorpyrifos  (EXP)
Cuprizon  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (ISO)
diethylstilbestrol  (EXP,ISO)
dioxygen  (EXP,ISO)
fentin chloride  (ISO)
furan  (ISO)
gamma-hexachlorocyclohexane  (ISO)
glycidol  (ISO)
hydrogen cyanide  (EXP)
lipopolysaccharide  (ISO)
melphalan  (ISO)
mercaptopurine  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
mirex  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nevirapine  (ISO)
nickel atom  (EXP)
ozone  (ISO)
paracetamol  (ISO)
PCB138  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
Pirarubicin  (ISO)
pirinixic acid  (EXP,ISO)
potassium cyanide  (EXP)
purine-6-thiol  (ISO)
rofecoxib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
valdecoxib  (ISO)
valproic acid  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal allantois morphology  (IAGP)
abnormal atrioventricular valve morphology  (IAGP)
abnormal axial skeleton morphology  (IAGP)
abnormal bone ossification  (IAGP)
abnormal brain vasculature morphology  (IAGP)
abnormal branching involved in lung morphogenesis  (IAGP)
abnormal bronchus morphology  (IAGP)
abnormal cardiac outflow tract development  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal centrosome morphology  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal dendrite morphology  (IAGP)
abnormal dendritic spine morphology  (IAGP)
abnormal dermomyotome development  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal direction of embryo turning  (IAGP)
abnormal direction of heart looping  (IAGP)
abnormal dorsal root ganglion morphology  (IAGP)
abnormal dorsal-ventral polarity of the somites  (IAGP)
abnormal embryo development  (IAGP)
abnormal embryonic erythrocyte morphology  (IAGP)
abnormal embryonic erythropoiesis  (IAGP)
abnormal embryonic neuroepithelial layer differentiation  (IAGP)
abnormal embryonic neuroepithelium morphology  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal epaxial muscle morphology  (IAGP)
abnormal erythrocyte morphology  (IAGP)
abnormal fetal atrioventricular canal morphology  (IAGP)
abnormal fetal liver hematopoietic progenitor cell morphology  (IAGP)
abnormal gait  (IAGP)
abnormal gastrocnemius morphology  (IEA)
abnormal gonadal ridge morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart size  (IAGP)
abnormal hematopoietic system morphology/development  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal hypaxial muscle morphology  (IAGP)
abnormal imprinting  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal limb morphology  (IAGP)
abnormal limb posture  (IAGP)
abnormal liver iron level  (IAGP)
abnormal male germ cell morphology  (IAGP)
abnormal mitosis  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal muscle development  (IAGP)
abnormal muscle fiber morphology  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal myocardial trabeculae morphology  (IAGP)
abnormal myogenesis  (IAGP)
abnormal myotome development  (IAGP)
abnormal nervous system development  (IAGP)
abnormal neuromuscular synapse morphology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal neuronal precursor proliferation  (IAGP)
abnormal osteoblast physiology  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal palate morphology  (IAGP)
abnormal pancreatic acinar cell morphology  (IAGP)
abnormal perichondrium morphology  (IAGP)
abnormal placenta labyrinth morphology  (IAGP)
abnormal placenta morphology  (IAGP)
abnormal placenta vasculature  (IAGP)
abnormal primitive streak morphology  (IAGP)
abnormal proximal convoluted tubule morphology  (IAGP)
abnormal proximal-distal axis patterning  (IAGP)
abnormal pulmonary valve development  (IAGP)
abnormal renal reabsorption  (IAGP)
abnormal sclerotome morphology  (IAGP)
abnormal skeletal muscle morphology  (IAGP)
abnormal skeleton development  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal skeleton physiology  (IAGP)
abnormal social investigation  (IAGP)
abnormal somite development  (IAGP)
abnormal somite shape  (IAGP)
abnormal somite size  (IAGP)
abnormal spermatid morphology  (IAGP)
abnormal spermatocyte morphology  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal spermatogonia morphology  (IAGP)
abnormal spinal cord morphology  (IAGP)
abnormal spinal nerve morphology  (IAGP)
abnormal sternocostal joint morphology  (IAGP)
abnormal sternum morphology  (IAGP)
abnormal stomach epithelium morphology  (IAGP)
abnormal stomach morphology  (IAGP)
abnormal stomach muscularis externa morphology  (IAGP)
abnormal striatum morphology  (IAGP)
abnormal survival  (IAGP)
abnormal vertebrae development  (IAGP)
abnormal vertebrae morphology  (IAGP)
abnormal vertebral body morphology  (IAGP)
abnormal vertebral column morphology  (IAGP)
abnormal visceral yolk sac morphology  (IAGP)
abnormal vitamin B12 level  (IAGP)
absent caudal vertebrae  (IAGP)
absent kidney  (IAGP)
absent primordial germ cells  (IAGP)
absent ribs  (IAGP)
absent tail  (IAGP)
absent vertebrae  (IAGP)
albuminuria  (IAGP)
anemia  (IAGP)
aneuploidy  (IAGP)
anisocytosis  (IAGP)
astrocytosis  (IAGP)
asymmetric sternocostal joints  (IAGP)
ataxia  (IAGP)
atelectasis  (IAGP)
atrial septal defect  (IAGP)
cachexia  (IAGP)
caudal vertebral fusion  (IAGP)
centrally nucleated skeletal muscle fibers  (IAGP)
cerebellum atrophy  (IAGP)
cleft secondary palate  (IAGP)
conotruncal ridge hyperplasia  (IAGP)
cyanosis  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mass  (IAGP)
decreased bone mineral density  (IAGP)
decreased bone resorption  (IAGP)
decreased bone strength  (IAGP)
decreased brain weight  (IAGP)
decreased brown adipose tissue amount  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased cellular sensitivity to ionizing radiation  (IAGP)
decreased circulating fibrinogen level  (IAGP)
decreased compact bone thickness  (IAGP)
decreased embryo size  (IAGP)
decreased fetal size  (IAGP)
decreased grip strength  (IAGP)
decreased hemoglobin content  (IAGP)
decreased locomotor activity  (IAGP)
decreased mean corpuscular hemoglobin  (IAGP)
decreased mean corpuscular volume  (IAGP)
decreased neuron number  (IAGP)
decreased osteoblast cell number  (IAGP)
decreased osteoclast cell number  (IAGP)
decreased primordial germ cell proliferation  (IAGP)
decreased skeletal muscle mass  (IAGP)
decreased survivor rate  (IAGP)
delayed bone ossification  (IAGP)
dextrocardia  (IAGP)
dilated brain ventricle  (IAGP)
dilated lateral ventricle  (IAGP)
dilated respiratory conducting tube  (IAGP)
domed cranium  (IAGP)
double outlet right ventricle  (IAGP)
edema  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality before implantation, complete penetrance  (IAGP)
embryonic lethality between somite formation and embryo turning, complete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
exocrine pancreatic insufficiency  (IAGP)
female infertility  (IAGP)
fused dorsal root ganglion  (IAGP)
heart valve hyperplasia  (IAGP)
hemorrhage  (IAGP)
hepatic necrosis  (IAGP)
herniated intestine  (IAGP)
hydrocephaly  (IAGP)
hydrops fetalis  (IAGP)
impaired branching involved in bronchus morphogenesis  (IAGP)
impaired branching involved in terminal bronchiole morphogenesis  (IAGP)
impaired coordination  (IAGP)
impaired limb coordination  (IAGP)
impaired righting response  (IAGP)
increased allantois apoptosis  (IAGP)
increased chronic myelocytic leukemia incidence  (IAGP)
increased circulating C-reactive protein level  (IAGP)
increased embryonic tissue cell apoptosis  (IAGP)
increased erythroid progenitor cell number  (IAGP)
increased hematopoietic stem cell number  (IAGP)
increased hepatocyte apoptosis  (IAGP)
increased intestinal iron level  (IAGP)
increased mammary gland tumor incidence  (IAGP)
increased mitotic index  (IAGP)
increased neuronal precursor cell number  (IAGP)
increased rib number  (IAGP)
increased spleen iron level  (IAGP)
increased urine protein level  (IAGP)
increased variability of skeletal muscle fiber size  (IAGP)
infertility  (IAGP)
intraventricular hemorrhage  (IAGP)
joint contracture  (IEA)
kidney cyst  (IAGP)
lethality at weaning, complete penetrance  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
lethality, complete penetrance  (IAGP)
limb grasping  (IAGP)
liver hypoplasia  (IAGP)
loose skin  (IAGP)
male infertility  (IAGP)
mammary gland hyperplasia  (IAGP)
meteorism  (IAGP)
microgliosis  (IAGP)
muscle weakness  (IAGP)
muscular atrophy  (IAGP)
neonatal lethality  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
occipital bone hypoplasia  (IAGP)
omphalocele  (IAGP)
open neural tube  (IAGP)
osteoporosis  (IAGP)
pallor  (IAGP)
pancreas cyst  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
poikilocytosis  (IAGP)
polydactyly  (IAGP)
polyhydramnios  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IAGP)
pulmonary hypoplasia  (IAGP)
pulmonary valve stenosis  (IAGP)
respiratory failure  (IAGP)
reticulocytosis  (IAGP)
rib fusion  (IAGP)
right aortic arch  (IAGP)
rostral body truncation  (IAGP)
short hindlimb  (IAGP)
short tail  (IAGP)
short tibia  (IAGP)
situs inversus  (IAGP)
small cerebellum  (IAGP)
small liver  (IAGP)
small testis  (IAGP)
thin myocardium  (IAGP)
thin myometrium  (IEA)
thin ventricle myocardium compact layer  (IAGP)
thin ventricular wall  (IAGP)
thrombocytopenia  (IAGP)
tracheoesophageal fistula  (IAGP)
transposition of great arteries  (IAGP)
vascular ring  (IAGP)
ventricular septal defect  (IAGP)
vertebral transformation  (IAGP)
vestigial tail  (IAGP)
waved hair  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. The Ski-Zeb2-Meox2 pathway provides a novel mechanism for regulation of the cardiac myofibroblast phenotype. Cunnington RH, etal., J Cell Sci. 2014 Jan 1;127(Pt 1):40-9. doi: 10.1242/jcs.126722. Epub 2013 Oct 23.
2. Molecular cloning of a diverged homeobox gene that is rapidly down-regulated during the G0/G1 transition in vascular smooth muscle cells. Gorski DH, etal., Mol Cell Biol 1993 Jun;13(6):3722-33.
3. Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice. Klezovitch O, etal., Genes Dev 2004 Mar 1;18(5):559-71.
4. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1363541   PMID:7554933   PMID:7607679   PMID:7623821   PMID:7909944   PMID:7964557   PMID:8565825   PMID:8945939   PMID:9032023   PMID:9118475   PMID:10349636   PMID:10403250  
PMID:10597226   PMID:10686601   PMID:11042159   PMID:11063256   PMID:11076861   PMID:11217851   PMID:11404088   PMID:11423130   PMID:11830577   PMID:11852098   PMID:11857795   PMID:11927540  
PMID:12051829   PMID:12230980   PMID:12477932   PMID:12490554   PMID:12607001   PMID:12732721   PMID:12925591   PMID:14516668   PMID:14769860   PMID:15024065   PMID:15037550   PMID:15048812  
PMID:15136140   PMID:15198985   PMID:15229648   PMID:15249135   PMID:15302604   PMID:15457215   PMID:15469978   PMID:15507213   PMID:15579506   PMID:15618518   PMID:15623804   PMID:15653949  
PMID:15655111   PMID:15870384   PMID:15872003   PMID:15956290   PMID:16007139   PMID:16054062   PMID:16116430   PMID:16141072   PMID:16141073   PMID:16254186   PMID:16284941   PMID:16319112  
PMID:16335786   PMID:16391232   PMID:16397867   PMID:16397869   PMID:16421190   PMID:16432225   PMID:16602821   PMID:16604518   PMID:16801545   PMID:16943277   PMID:16943278   PMID:16962829  
PMID:17023579   PMID:17030618   PMID:17178906   PMID:17211872   PMID:17219248   PMID:17294368   PMID:17297445   PMID:17304211   PMID:17304352   PMID:17312149   PMID:17369402   PMID:17445091  
PMID:17448993   PMID:17468757   PMID:17557897   PMID:17575307   PMID:17582330   PMID:17601531   PMID:17631919   PMID:17693261   PMID:17699161   PMID:17913785   PMID:17940036   PMID:17977525  
PMID:18028899   PMID:18079970   PMID:18202372   PMID:18218778   PMID:18232736   PMID:18265010   PMID:18287559   PMID:18332218   PMID:18342849   PMID:18378898   PMID:18396137   PMID:18453592  
PMID:18470539   PMID:18519639   PMID:18538592   PMID:18539926   PMID:18548006   PMID:18559482   PMID:18606782   PMID:18614237   PMID:18615733   PMID:18617570   PMID:18676810   PMID:18701065  
PMID:18701073   PMID:18710940   PMID:18792406   PMID:18819932   PMID:18854136   PMID:18948418   PMID:18948620   PMID:19010921   PMID:19087265   PMID:19112489   PMID:19121383   PMID:19144718  
PMID:19164512   PMID:19217431   PMID:19219045   PMID:19251646   PMID:19284699   PMID:19345332   PMID:19383287   PMID:19409885   PMID:19411629   PMID:19433082   PMID:19464366   PMID:19515977  
PMID:19520072   PMID:19528295   PMID:19541642   PMID:19591821   PMID:19592082   PMID:19633665   PMID:19666516   PMID:19706423   PMID:19776388   PMID:19788412   PMID:19797524   PMID:19805353  
PMID:20010873   PMID:20018614   PMID:20023434   PMID:20059953   PMID:20211142   PMID:20223200   PMID:20236942   PMID:20351096   PMID:20401461   PMID:20403324   PMID:20412779   PMID:20417199  
PMID:20458145   PMID:20473270   PMID:20498044   PMID:20533406   PMID:20534475   PMID:20645308   PMID:20665730   PMID:20686481   PMID:20702562   PMID:20798259   PMID:20845430   PMID:20862291  
PMID:20885949   PMID:20932939   PMID:20941375   PMID:21040844   PMID:21059851   PMID:21076060   PMID:21094155   PMID:21103374   PMID:21185278   PMID:21245383   PMID:21262768   PMID:21267068  
PMID:21283715   PMID:21368124   PMID:21441452   PMID:21460858   PMID:21490063   PMID:21494564   PMID:21533046   PMID:21540289   PMID:21552207   PMID:21555567   PMID:21586752   PMID:21600200  
PMID:21664579   PMID:21745337   PMID:21791606   PMID:21816965   PMID:21831921   PMID:21835346   PMID:21873635   PMID:21941297   PMID:21958845   PMID:21963425   PMID:22022495   PMID:22219351  
PMID:22228100   PMID:22228755   PMID:22266795   PMID:22331465   PMID:22371266   PMID:22396659   PMID:22422825   PMID:22473956   PMID:22532833   PMID:22721776   PMID:22821887   PMID:22875923  
PMID:22899986   PMID:22908258   PMID:22911824   PMID:22958921   PMID:22987640   PMID:22988430   PMID:23035250   PMID:23100430   PMID:23296705   PMID:23354439   PMID:23555292   PMID:23633510  
PMID:23657012   PMID:23703832   PMID:23758685   PMID:23762348   PMID:23843612   PMID:23894296   PMID:23973221   PMID:23975099   PMID:24038871   PMID:24146773   PMID:24168030   PMID:24225308  
PMID:24267650   PMID:24411941   PMID:24493797   PMID:24509509   PMID:24550112   PMID:24596343   PMID:24652990   PMID:24672010   PMID:24705491   PMID:24810051   PMID:24875805   PMID:24876386  
PMID:24952961   PMID:24980834   PMID:24995796   PMID:25070948   PMID:25078604   PMID:25145929   PMID:25209980   PMID:25324524   PMID:25360623   PMID:25377550   PMID:25561514   PMID:25574476  
PMID:25609609   PMID:25716980   PMID:25733582   PMID:25977363   PMID:25995473   PMID:26028220   PMID:26152694   PMID:26237517   PMID:26245899   PMID:26341559   PMID:26537451   PMID:26538636  
PMID:26578792   PMID:26588779   PMID:26779602   PMID:26789794   PMID:26821949   PMID:26903600   PMID:27038752   PMID:27048647   PMID:27120339   PMID:27134830   PMID:27143421   PMID:27184477  
PMID:27270835   PMID:27286066   PMID:27381226   PMID:27496731   PMID:27505464   PMID:27776119   PMID:27856617   PMID:27939640   PMID:28067668   PMID:28076796   PMID:28077597   PMID:28135240  
PMID:28250425   PMID:28326537   PMID:28355185   PMID:28366204   PMID:28371069   PMID:28552557   PMID:28691711   PMID:28694332   PMID:28729032   PMID:28910376   PMID:28920104   PMID:28947535  
PMID:29029094   PMID:29209830   PMID:29234109   PMID:29297601   PMID:29361558   PMID:29415886   PMID:29507411   PMID:29686099   PMID:30114334   PMID:30121012   PMID:30532001   PMID:30552867  
PMID:30635240   PMID:30755437   PMID:30816177   PMID:30940539   PMID:31092920   PMID:31241463   PMID:31265868   PMID:31285585   PMID:31308417   PMID:31369031   PMID:31499015   PMID:31540031  
PMID:31628891   PMID:31886826   PMID:32041873   PMID:32041892   PMID:32052574   PMID:32353019   PMID:32597756   PMID:32800757   PMID:33041772   PMID:33184218   PMID:33218046   PMID:33454424  
PMID:33600594   PMID:33681212   PMID:34343497   PMID:34386488   PMID:34617884   PMID:34669700   PMID:34963058   PMID:35029322   PMID:35044299   PMID:36400788   PMID:36460641   PMID:37246520  
PMID:37318790   PMID:37337907   PMID:37729060   PMID:37845212   PMID:38280850  


Genomics

Comparative Map Data
Meox2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391237,158,539 - 37,229,533 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1237,158,539 - 37,229,533 (+)EnsemblGRCm39 Ensembl
GRCm381237,108,540 - 37,179,534 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1237,108,540 - 37,179,534 (+)EnsemblGRCm38mm10GRCm38
MGSCv371237,835,133 - 37,906,115 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361237,618,812 - 37,689,794 (+)NCBIMGSCv36mm8
Celera1238,548,347 - 38,608,374 (+)NCBICelera
Cytogenetic Map12A3NCBI
cM Map1216.84NCBI
MEOX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38715,611,212 - 15,686,683 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl715,611,212 - 15,686,683 (-)EnsemblGRCh38hg38GRCh38
GRCh37715,650,837 - 15,726,308 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36715,617,362 - 15,692,833 (-)NCBINCBI36Build 36hg18NCBI36
Build 34715,424,076 - 15,499,534NCBI
Celera715,630,544 - 15,706,034 (-)NCBICelera
Cytogenetic Map7p21.2NCBI
HuRef715,535,672 - 15,611,245 (-)NCBIHuRef
CHM1_1715,650,236 - 15,725,903 (-)NCBICHM1_1
T2T-CHM13v2.0715,744,456 - 15,819,945 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2715,703,946 - 15,779,448 (-)NCBI
Meox2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8659,584,025 - 59,644,722 (+)NCBIGRCr8
mRatBN7.2653,856,760 - 53,917,467 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl653,856,758 - 53,917,467 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx654,156,909 - 54,224,375 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0654,471,799 - 54,539,259 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0653,944,436 - 54,011,867 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0656,625,768 - 56,689,195 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl656,625,650 - 56,689,238 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0666,231,865 - 66,293,008 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4655,895,760 - 55,957,066 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1655,898,885 - 55,960,192 (+)NCBI
Celera652,995,636 - 53,056,305 (+)NCBICelera
Cytogenetic Map6q21NCBI
Meox2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541018,924,605 - 18,988,478 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541018,924,669 - 18,988,478 (-)NCBIChiLan1.0ChiLan1.0
MEOX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2620,447,134 - 20,522,883 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1768,769,680 - 68,847,538 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0716,268,225 - 16,343,914 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1715,598,460 - 15,673,935 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl715,598,466 - 15,673,935 (-)Ensemblpanpan1.1panPan2
MEOX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11430,258,737 - 30,324,438 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1429,864,318 - 30,324,006 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1429,780,887 - 29,846,794 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01430,174,433 - 30,240,144 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1430,174,125 - 30,239,967 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11430,276,649 - 30,342,528 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01429,996,478 - 30,062,402 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01430,307,318 - 30,373,202 (-)NCBIUU_Cfam_GSD_1.0
Meox2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511874,564,415 - 74,629,128 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365462,239,442 - 2,304,099 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365462,239,442 - 2,304,099 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MEOX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl984,943,199 - 85,010,157 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1984,945,178 - 85,009,939 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2993,770,697 - 93,771,213 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MEOX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12142,403,474 - 42,476,469 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2142,403,741 - 42,476,453 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604262,025,173 - 62,098,121 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Meox2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473914,483,789 - 14,547,374 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473914,483,750 - 14,547,491 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Meox2
2176 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:593
Count of miRNA genes:386
Interacting mature miRNAs:422
Transcripts:ENSMUST00000041183
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142234Tmc1m3_mTmc1 modifier 3 (mouse)Not determined12541844077031203Mouse
1301163Eae16_msusceptibility to experimental allergic encephalomyelitis 16 (mouse)Not determined12772315841723301Mouse
13208568Bmiq11_mbody mass index QTL 11 (mouse)12805000040049999Mouse
1301037Cd4ts5_mCD4 T cell subset 5 (mouse)Not determined12835244442352581Mouse
1301723Fcsa7_mfemoral cross-sectional area 7 (mouse)Not determined12949100443491112Mouse
27226753Femd7_mfemur midshaft diameter 7, 10 week (mouse)12955000084146774Mouse
14746972Manh72_mmandible shape 72 (mouse)121061528144615281Mouse
10401249Bglu15_mblood glucose level 15 (mouse)Not determined121062064244620809Mouse
13524843Ppiq8_mprepulse inhibition QTL 8 (mouse)121104319450945796Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121166000197176774Mouse
4141516slwr_mslowlearner (mouse)Not determined1239247546392614Mouse
13524839Ppiq10_mprepulse inhibition QTL 10 (mouse)121304319554945798Mouse
10043977Obq34_mobesity QTL 34 (mouse)Not determined121514733149147331Mouse
1558978Cplaq10_mcircadian period of locomotor activity 10 (mouse)Not determined121534102679040364Mouse
26884413Bzwq9_mbi-zygomatic width QTL 9, 10 week (mouse)121615000147746783Mouse
1301574Lmblgq5_mlimb length QTL 5 (mouse)Not determined121759644780956883Mouse
15039339Nmrs29_mNAFLD-associated magnetic resonance shift 29 (mouse)121782585251825852Mouse
10043848Hdlq90_mHDL QTL 90 (mouse)Not determined121783993951840081Mouse
1300870Ath18_matherosclerosis 18 (mouse)Not determined121825996652260067Mouse
12904956Edlmmq10_mextensor digitorum longus muscle mass QTL 10 (mouse)121973983353739833Mouse
1302172Skts5_mskin tumor susceptibility 5 (mouse)Not determined122214886656149016Mouse
1301989Hdlq18_mHDL QTL 18 (mouse)Not determined122916068563160884Mouse
1300636Gct2_mgranulosa cell tumorigenesis 2 (mouse)Not determined122916068563160884Mouse
4141843Moen3_mmodifier of engrailed QTL 3 (mouse)Not determined122980158463801733Mouse
14747008Mancz10_mmandible centroid size 10 (mouse)122986352263863522Mouse
10402492Dipa8_mdrug induced psychomotor activation 8 (mouse)Not determined123493387268934019Mouse
1300818Bbaa10_mB.burgdorferi-associated arthritis 10 (mouse)Not determined123509100465511019Mouse
12879483Asp1_maudiogenic seizure prone 1 (mouse)123528549646801733Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse

Markers in Region
AI528662  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381237,179,271 - 37,179,390UniSTSGRCm38
MGSCv371237,905,858 - 37,905,977UniSTSGRCm37
Celera1238,608,117 - 38,608,236UniSTS
Cytogenetic Map12A3UniSTS
cM Map1220.0UniSTS
Whitehead/MRC_RH12345.56UniSTS
Z16406  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381237,178,487 - 37,178,647UniSTSGRCm38
MGSCv371237,905,074 - 37,905,234UniSTSGRCm37
Celera1238,607,333 - 38,607,493UniSTS
Cytogenetic Map12A3UniSTS
cM Map1220.0UniSTS
Whitehead/MRC_RH12342.52UniSTS
Whitehead_YAC9 UniSTS
Meox2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381237,167,335 - 37,167,395UniSTSGRCm38
MGSCv371237,893,922 - 37,893,982UniSTSGRCm37
Celera1238,596,171 - 38,596,231UniSTS
Cytogenetic Map12A3UniSTS
cM Map1220.0UniSTS
cM Map1220.0UniSTS
Meox2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3813103,357,588 - 103,358,010UniSTSGRCm38
GRCm381238,865,653 - 38,866,076UniSTSGRCm38
MGSCv371239,592,240 - 39,592,663UniSTSGRCm37
MGSCv3713104,147,668 - 104,148,090UniSTSGRCm37
Celera1240,287,494 - 40,287,917UniSTS
Cytogenetic Map12A3UniSTS
Cytogenetic Map13D1UniSTS
Cytogenetic Map12A3-B1UniSTS
cM Map1220.0UniSTS
Z16406  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381237,178,491 - 37,178,640UniSTSGRCm38
MGSCv371237,905,078 - 37,905,227UniSTSGRCm37
Celera1238,607,337 - 38,607,486UniSTS
Cytogenetic Map12A3UniSTS
Whitehead/MRC_RH12342.52UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000041183   ⟹   ENSMUSP00000043587
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1237,158,539 - 37,229,533 (+)Ensembl
GRCm38.p6 Ensembl1237,108,540 - 37,179,534 (+)Ensembl
RefSeq Acc Id: NM_008584   ⟹   NP_032610
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391237,158,539 - 37,229,533 (+)NCBI
GRCm381237,108,540 - 37,179,534 (+)NCBI
MGSCv371237,835,133 - 37,906,115 (+)RGD
Celera1238,548,347 - 38,608,374 (+)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032610   ⟸   NM_008584
- UniProtKB: Q544T6 (UniProtKB/Swiss-Prot),   P32443 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000043587   ⟸   ENSMUST00000041183
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P32443-F1-model_v2 AlphaFold P32443 1-303 view protein structure

Promoters
RGD ID:8678168
Promoter ID:EPDNEW_M17115
Type:initiation region
Name:Meox2_1
Description:Mus musculus mesenchyme homeobox 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381237,108,540 - 37,108,600EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:103219 AgrOrtholog
Ensembl Genes ENSMUSG00000036144 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000041183 ENTREZGENE
  ENSMUST00000041183.7 UniProtKB/Swiss-Prot
Gene3D-CATH Homeodomain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_metazoa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MOX-1/MOX-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17286 UniProtKB/Swiss-Prot
MGD MGI:103219 ENTREZGENE
NCBI Gene 17286 ENTREZGENE
PANTHER HOMEOBOX PROTEIN MOX-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24328 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Meox2 PhenoGen
PRINTS HOMEOBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt MEOX2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q544T6 ENTREZGENE
  Q99M23_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q544T6 UniProtKB/Swiss-Prot