IGFBP3 (insulin like growth factor binding protein 3) - Rat Genome Database

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Gene: IGFBP3 (insulin like growth factor binding protein 3) Homo sapiens
Analyze
Symbol: IGFBP3
Name: insulin like growth factor binding protein 3
RGD ID: 736042
HGNC Page HGNC:5472
Description: Enables insulin-like growth factor I binding activity and protein tyrosine phosphatase activator activity. Involved in several processes, including negative regulation of smooth muscle cell migration; negative regulation of smooth muscle cell proliferation; and positive regulation of myoblast differentiation. Acts upstream of or within negative regulation of cell population proliferation; negative regulation of protein phosphorylation; and protein phosphorylation. Located in extracellular space and nucleus. Part of insulin-like growth factor ternary complex. Implicated in several diseases, including Alzheimer's disease; Turner syndrome; diabetes mellitus (multiple); prostate cancer; and transitional cell carcinoma. Biomarker of several diseases, including Barrett's esophagus; Down syndrome; autoimmune disease (multiple); bone disease (multiple); and urinary system cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: acid stable subunit of the 140 K IGF complex; binding protein 29; binding protein 53; BP-53; growth hormone-dependent binding protein; IBP-3; IBP3; IGF-binding protein 3; IGFBP-3; insulin-like growth factor binding protein 3; insulin-like growth factor-binding protein 3
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38745,912,245 - 45,921,272 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl745,912,245 - 45,921,874 (-)Ensemblhg38GRCh38
GRCh37745,951,844 - 45,960,871 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36745,918,369 - 45,927,396 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34745,725,189 - 45,734,057NCBI
Celera746,050,761 - 46,059,785 (-)NCBICelera
Cytogenetic Map7p12.3NCBI
HuRef745,836,799 - 45,845,824 (-)NCBIHuRef
CHM1_1745,956,047 - 45,965,072 (-)NCBICHM1_1
T2T-CHM13v2.0746,073,961 - 46,082,986 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2745,991,173 - 46,000,198 (-)NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acoustic neuroma  (IEP)
Acute-Phase Reaction  (IDA)
Alzheimer's disease  (IDA,IEP,ISO)
ankylosing spondylitis  (IEP)
arteriosclerosis  (IEP)
autistic disorder  (EXP)
Barrett's esophagus  (IEP)
beta thalassemia  (IEP)
Brain Hypoxia-Ischemia  (ISO)
breast cancer  (IAGP,IEP)
Burns  (ISO)
cervix uteri carcinoma in situ  (IEP)
Closed Head Injuries  (IEP)
Colorectal Neoplasms  (EXP)
Congenital Adrenal Hyperplasia due to 21 Hydroxylase Deficiency  (IEP)
congenital diaphragmatic hernia  (ISO)
congenital disorder of glycosylation Ia  (IEP)
Coronary Disease  (IDA)
COVID-19  (HEP)
cystic fibrosis  (IEP)
Down syndrome  (IEP)
Dwarfism  (IEP)
Endometrial Neoplasms  (IEP)
Endometrioid Carcinomas  (IEP)
Endotoxemia  (ISO)
epidermolysis bullosa dystrophica  (IEP)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (EXP)
Fetal Growth Retardation  (IDA,IEP,ISO)
Fetal Macrosomia  (IEP)
high grade glioma  (IEP)
ichthyosis  (IEP)
impotence  (ISO)
inflammatory bowel disease  (IAGP)
Insulin Resistance  (IDA)
Malocclusion  (ISO)
McCune Albright syndrome  (IEP)
Metabolic Bone Diseases  (IDA)
myeloid leukemia  (IEP)
Myocardial Ischemia  (EXP)
obesity  (ISO)
ornithine carbamoyltransferase deficiency  (IEP)
osteoarthritis  (IEP)
osteoporosis  (IEP)
Ovarian Neoplasms  (IDA,IEP)
pleomorphic xanthoastrocytoma  (IAGP)
primary progressive multiple sclerosis  (IEP)
prostate cancer  (IAGP)
Prostatic Neoplasms  (EXP)
pulmonary fibrosis  (IEP)
renal cell carcinoma  (IEP)
retinopathy of prematurity  (IEP)
rheumatoid arthritis  (EXP)
Spinal Fractures  (IEP)
Spontaneous Abortions  (EXP)
stomach cancer  (IEP)
Stomach Neoplasms  (EXP)
systemic scleroderma  (IEP)
tonsillitis  (IEP)
transitional cell carcinoma  (EXP,IDA)
Turner syndrome  (IDA)
type 1 diabetes mellitus  (IDA,IEP)
type 2 diabetes mellitus  (IDA)
urinary bladder cancer  (EXP,IEP)
Uterine Cervical Neoplasms  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(R)-lipoic acid  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,5-hexanedione  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (EXP)
2-methoxyethanol  (ISO)
2-methylcholine  (EXP)
2-nitrofluorene  (ISO)
2-nitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3,4-dichloroaniline  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
9-cis-retinoic acid  (EXP)
acetamide  (ISO)
actinomycin D  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-4-oxoretinoic acid  (EXP)
all-trans-retinoic acid  (EXP,ISO)
aluminium sulfate (anhydrous)  (EXP)
ammonium chloride  (ISO)
ampicillin  (EXP)
Archazolid B  (EXP)
aristolochic acid A  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
azathioprine  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
Benzo[b]fluorene  (ISO)
beta-D-glucosamine  (ISO)
beta-lapachone  (EXP)
beta-naphthoflavone  (EXP)
bexarotene  (ISO)
bicalutamide  (EXP,ISO)
bilirubin IXalpha  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromochloroacetic acid  (ISO)
bucladesine  (EXP)
buta-1,3-diene  (ISO)
butanal  (EXP)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calciol  (ISO)
calcitriol  (EXP)
captan  (ISO)
carbamazepine  (EXP)
carbon nanotube  (EXP,ISO)
carmustine  (ISO)
chenodeoxycholic acid  (EXP)
chloroethene  (ISO)
chlorohydrocarbon  (EXP)
chlorophyllin  (EXP)
chloroprene  (ISO)
cholesterol  (ISO)
chromium(6+)  (EXP)
cisplatin  (EXP)
clobetasol  (ISO)
clofibric acid  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
CU-O LINKAGE  (EXP)
curcumin  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP)
cytarabine  (EXP)
decabromodiphenyl ether  (EXP)
dehydroepiandrosterone  (EXP)
deoxycholic acid  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP)
dichlorine  (ISO)
diclofenac  (EXP)
Didecyldimethylammonium  (EXP)
diethyl malate  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
diuron  (EXP,ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
entinostat  (EXP)
ethanol  (EXP)
fenamidone  (ISO)
flavonoids  (ISO)
flutamide  (EXP,ISO)
folic acid  (ISO)
folpet  (ISO)
fonofos  (EXP)
fructose  (ISO)
fulvestrant  (EXP)
gadolinium trichloride  (ISO)
gemcitabine  (EXP)
genistein  (EXP)
glafenine  (ISO)
glutathione  (ISO)
glycidol  (ISO)
glycochenodeoxycholic acid  (EXP)
glycocholic acid  (EXP)
glycodeoxycholic acid  (EXP)
graphene oxide  (EXP)
hexachlorobenzene  (EXP)
hydroquinone  (EXP)
indometacin  (EXP)
iron atom  (EXP,ISO)
iron dichloride  (EXP)
iron(0)  (EXP,ISO)
isoflavones  (EXP)
isoprenaline  (ISO)
isotretinoin  (EXP)
ivermectin  (ISO)
ketamine  (ISO)
lead diacetate  (EXP)
leflunomide  (EXP)
levonorgestrel  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
LY294002  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
medroxyprogesterone acetate  (EXP)
mercury dibromide  (EXP)
methapyrilene  (ISO)
methidathion  (ISO)
methimazole  (ISO)
methotrexate  (EXP,ISO)
methoxyacetic acid  (ISO)
methylmercury chloride  (EXP)
methylmercury(1+)  (ISO)
methylparaben  (EXP)
mifepristone  (EXP)
mitoxantrone  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
Monobutylphthalate  (ISO)
monosodium L-glutamate  (ISO)
Muraglitazar  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (EXP)
naphthalene  (ISO)
nefazodone  (ISO)
nickel atom  (EXP)
nickel dichloride  (EXP)
nickel subsulfide  (EXP)
nimesulide  (ISO)
nitrofen  (ISO)
nonanedioic acid  (ISO)
Nutlin-3  (EXP)
okadaic acid  (EXP)
oxaliplatin  (EXP,ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (EXP)
p-toluidine  (ISO)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
parathion  (EXP)
PD 0325901  (EXP)
pentanal  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
Pf-06840003  (EXP)
phenobarbital  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP,ISO)
propanal  (EXP)
propiconazole  (ISO)
quercetin  (EXP,ISO)
quinolin-8-ol  (EXP)
rac-lactic acid  (EXP)
raloxifene  (EXP)
resveratrol  (EXP)
rifampicin  (EXP)
Rutecarpine  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
SB 431542  (EXP)
selenium atom  (EXP)
serpentine asbestos  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (EXP)
sirtinol  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
Soman  (ISO)
streptozocin  (ISO)
succimer  (EXP)
sulfasalazine  (ISO)
sunitinib  (EXP)
tamibarotene  (EXP)
tamoxifen  (EXP,ISO)
taurine  (EXP)
temozolomide  (EXP)
terbufos  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP,ISO)
testosterone undecanoate  (EXP)
Tetrachlorobisphenol A  (EXP)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thalidomide  (EXP,ISO)
thapsigargin  (EXP)
thioacetamide  (ISO)
thiram  (EXP)
tioguanine  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP,ISO)
tremolite asbestos  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (EXP)
troglitazone  (EXP)
tunicamycin  (EXP)
urethane  (EXP)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vandetanib  (EXP)
vinclozolin  (ISO)
zearalenone  (EXP)
zebularine  (EXP)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Pegvisomant for the treatment of gsp-mediated growth hormone excess in patients with McCune-Albright syndrome. Akintoye SO, etal., J Clin Endocrinol Metab. 2006 Aug;91(8):2960-6. Epub 2006 May 23.
2. ZD6474 inhibits tumor growth and intraperitoneal dissemination in a highly metastatic orthotopic gastric cancer model. Arao T, etal., Int J Cancer. 2006 Jan 15;118(2):483-9. doi: 10.1002/ijc.21340.
3. Cognitive and neuroendocrine response to transdermal estrogen in postmenopausal women with Alzheimer's disease: results of a placebo-controlled, double-blind, pilot study. Asthana S, etal., Psychoneuroendocrinology. 1999 Aug;24(6):657-77.
4. Reduction of IGF-binding protein-3 as a potential marker of intra-uterine growth restriction. Baker Méio MD, etal., J Perinat Med. 2009;37(6):689-93. doi: 10.1515/JPM.2009.122.
5. Circulating levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in patients with severe head injury. Beeton CA, etal., J Bone Joint Surg Br. 2002 Apr;84(3):434-9.
6. The interactive effect of GHR-exon 3 and -202 A/C IGFBP3 polymorphisms on rhGH responsiveness and treatment outcomes in patients with Turner syndrome. Braz AF, etal., J Clin Endocrinol Metab. 2012 Apr;97(4):E671-7. doi: 10.1210/jc.2011-2521. Epub 2012 Jan 25.
7. Gene expression patterns of insulin-like growth factor 1, insulin-like growth factor 2 and insulin-like growth factor binding protein 3 in human placenta from pregnancies with intrauterine growth restriction. Börzsönyi B, etal., J Perinat Med. 2011 Nov;39(6):701-7. doi: 10.1515/JPM.2011.090. Epub 2011 Aug 8.
8. Inverse correlation between serum free IGF-I and IGFBP-3 levels and blood pressure in patients affected with type 1 diabetes. Capoluongo E, etal., Cytokine. 2006 Jun;34(5-6):303-11. Epub 2006 Aug 2.
9. Insulin-like growth factor binding protein-3 in the detection of fetal Down syndrome pregnancies. Chu DC, etal., Obstet Gynecol. 1998 Feb;91(2):192-5.
10. Over expression of insulin-like growth factor binding protein 3 in clear cell renal cell carcinoma. Chuang ST, etal., J Urol. 2008 Feb;179(2):445-9.
11. Rh/IGF-I/rhIGFBP-3 administration to patients with type 2 diabetes mellitus reduces insulin requirements while also lowering fasting glucose. Clemmons DR, etal., Growth Horm IGF Res. 2005 Aug;15(4):265-74.
12. Short stature in children with sickle cell anemia correlates with alterations in the IGF-I axis. Collett-Solberg PF, etal., J Pediatr Endocrinol Metab. 2007 Feb;20(2):211-8.
13. Roles of insulin-like growth factor (IGF) binding proteins in regulating IGF actions. Duan C and Xu Q, Gen Comp Endocrinol. 2005 May 15;142(1-2):44-52. Epub 2005 Feb 5.
14. Effects of Adenotonsillectomy on Serum Levels of IGF-1 and IGFBP-3 and Growth Indices in Children with Adenotonsillar Hypertrophy or Recurrent Tonsillitis. Farmarzi M, etal., Iran J Otorhinolaryngol. 2016 Sep;28(88):329-335.
15. Associations of insulin-like growth factors, insulin-like growth factor binding proteins and acid-labile subunit with coronary heart disease. Fischer F, etal., Clin Endocrinol (Oxf). 2004 Nov;61(5):595-602.
16. Differential transcriptome analysis of intraarticular lesional vs intact cartilage reveals new candidate genes in osteoarthritis pathophysiology. Geyer M, etal., Osteoarthritis Cartilage. 2009 Mar;17(3):328-35. doi: 10.1016/j.joca.2008.07.010. Epub 2008 Sep 4.
17. Insulin-like growth factor binding protein-3 in preterm infants with retinopathy of prematurity. Gharehbaghi MM, etal., Indian J Ophthalmol. 2012 Nov-Dec;60(6):527-30. doi: 10.4103/0301-4738.103782.
18. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
19. Reduced free IGF-I and increased IGFBP-3 proteolysis in Turner syndrome: modulation by female sex steroids. Gravholt CH, etal., Am J Physiol Endocrinol Metab. 2001 Feb;280(2):E308-14.
20. The GH-IGF-IGFBP axis is changed in Turner syndrome: partial normalization by HRT. Gravholt CH, etal., Growth Horm IGF Res. 2006 Oct-Dec;16(5-6):332-9. Epub 2006 Oct 25.
21. Changes of insulin-mediated protein kinases phosphorylation and the expression of IGFBP-3 in skeletal muscle of streptozotocin-diabetic mice. Grzelkowska-Kowalczyk K and Wieteska W, Pol J Vet Sci. 2005;8(3):231-40.
22. Elevated serum insulin-like growth factor (IGF-1) and IGF binding protein-3 levels in patients with systemic sclerosis: possible role in development of fibrosis. Hamaguchi Y, etal., J Rheumatol. 2008 Dec;35(12):2363-71. doi: 10.3899/jrheum.080340. Epub 2008 Nov 1.
23. IGF-1 and IGFBP-3 gene variants influence on serum levels and prostate cancer risk in African-Americans. Hernandez W, etal., Carcinogenesis. 2007 Oct;28(10):2154-9. Epub 2007 Aug 27.
24. EZH2 polycomb transcriptional repressor expression correlates with methylation of the APAF-1 gene in superficial transitional cell carcinoma of the bladder. Hinz S, etal., Tumour Biol. 2007;28(3):151-7. Epub 2007 Jun 1.
25. Grade-specific prostate cancer associations of IGF1 (CA)19 repeats and IGFBP3-202A/C in blacks and whites. Hoyo C, etal., J Natl Med Assoc. 2007 Jul;99(7):718-22.
26. Effect of inducible nitric oxide synthase inhibition by aminoguanidine on insulin-like growth factor binding protein-3 in adjuvant-induced arthritic rats. Ibanez de Caceres I, etal., Eur J Pharmacol. 2003 Nov 28;481(2-3):293-9.
27. Insulin-like growth factor I in combination with insulin-like growth factor binding protein 3 affects the hepatic acute phase response and hepatic morphology in thermally injured rats. Jeschke MG, etal., Ann Surg. 2000 Mar;231(3):408-16.
28. Reduced serum levels of the growth hormone-dependent insulin-like growth factor binding protein and a negative bone balance at the level of individual remodeling units in idiopathic osteoporosis in men. Johansson AG, etal., J Clin Endocrinol Metab. 1997 Sep;82(9):2795-8.
29. Serum but not cerebrospinal fluid levels of insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3) are increased in Alzheimer's disease. Johansson P, etal., Psychoneuroendocrinology. 2013 Sep;38(9):1729-37. doi: 10.1016/j.psyneuen.2013.02.006. Epub 2013 Mar 6.
30. Serum IGF-binding protein-6 and prostate specific antigen in breast cancer. Kaulsay KK, etal., Eur J Endocrinol. 1999 Feb;140(2):164-8.
31. Circulating insulin-like growth factor-1 and insulin-like growth factor binding protein-3 are associated with early carotid atherosclerosis. Kawachi S, etal., Arterioscler Thromb Vasc Biol. 2005 Mar;25(3):617-21. Epub 2004 Dec 29.
32. Insulin-like growth factor binding protein-3 induces insulin resistance in adipocytes in vitro and in rats in vivo. Kim HS, etal., Pediatr Res. 2007 Feb;61(2):159-64.
33. Insulin-like growth factor binding protein 3 in inflammatory bowel disease. Kirman I, etal., Dig Dis Sci. 2005 Apr;50(4):780-4.
34. Serum insulin-like growth factor-I (IGF-I) IGF binding protein-3 (IGFBP-3) and leptin levels are related to abdominal aortic intima-media thickness in macrosomic newborns. Koklu E, etal., Growth Horm IGF Res. 2007 Feb;17(1):26-32. Epub 2006 Nov 20.
35. Serum insulin-like growth factor-I (IGF-I), IGF-binding protein-3, and growth hormone levels in collodion babies: a case-control study. Kurtoglu S, etal., J Pediatr Endocrinol Metab. 2008 Jul;21(7):689-94.
36. Expression of insulin-like growth factor binding proteins in the rat kidney: effects of long-term diabetes. Landau D, etal., Endocrinology. 1995 May;136(5):1835-42. doi: 10.1210/endo.136.5.7536658.
37. Acute response of IGF-I and IGF binding proteins induced by thermal injury. Lang CH, etal., Am J Physiol Endocrinol Metab. 2000 Jun;278(6):E1087-96.
38. Perinatal hypoxia-ischemia decreased neuronal but increased cerebral vascular endothelial IGFBP3 expression. Lee WH, etal., Endocrine. 1999 Oct;11(2):181-8.
39. No association between genetic polymorphisms in IGF-I and IGFBP-3 and prostate cancer. Li L, etal., Cancer Epidemiol Biomarkers Prev. 2004 Mar;13(3):497-8.
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PMID:36800719   PMID:36853324   PMID:37188982   PMID:37253773   PMID:37451139   PMID:37511378   PMID:37690686   PMID:37792867   PMID:37948568   PMID:37950229   PMID:38224009   PMID:38468402  
PMID:38496616   PMID:39183355  


Genomics

Comparative Map Data
IGFBP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38745,912,245 - 45,921,272 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl745,912,245 - 45,921,874 (-)Ensemblhg38GRCh38
GRCh37745,951,844 - 45,960,871 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36745,918,369 - 45,927,396 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34745,725,189 - 45,734,057NCBI
Celera746,050,761 - 46,059,785 (-)NCBICelera
Cytogenetic Map7p12.3NCBI
HuRef745,836,799 - 45,845,824 (-)NCBIHuRef
CHM1_1745,956,047 - 45,965,072 (-)NCBICHM1_1
T2T-CHM13v2.0746,073,961 - 46,082,986 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2745,991,173 - 46,000,198 (-)NCBI
Igfbp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39117,156,086 - 7,165,498 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl117,156,086 - 7,163,923 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38117,206,086 - 7,215,498 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl117,206,086 - 7,213,923 (-)Ensemblmm10GRCm38
MGSCv37117,106,089 - 7,113,926 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36117,108,384 - 7,113,834 (-)NCBIMGSCv36mm8
Celera117,681,286 - 7,689,161 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map114.75NCBI
Igfbp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81486,270,208 - 86,277,944 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1486,270,208 - 86,277,944 (-)EnsemblGRCr8
mRatBN7.21482,056,347 - 82,064,083 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1482,056,347 - 82,064,083 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1486,457,400 - 86,465,160 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01487,697,249 - 87,705,011 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01484,145,931 - 84,153,669 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01487,457,647 - 87,465,374 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1487,457,647 - 87,465,374 (-)Ensemblrn6Rnor6.0
Rnor_5.01481,091,987 - 81,099,675 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41487,959,153 - 87,967,085 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1481,130,767 - 81,138,473 (-)NCBICelera
RGSC_v3.11487,978,297 - 87,986,223 (-)NCBI
RH 3.4 Map14598.5RGD
Cytogenetic Map14q21NCBI
Igfbp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554566,795,604 - 6,800,845 (+)Ensembl
ChiLan1.0NW_0049554566,795,560 - 6,802,147 (+)NCBIChiLan1.0ChiLan1.0
IGFBP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2650,797,505 - 50,806,866 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1799,122,231 - 99,131,164 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0746,564,234 - 46,573,145 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1746,681,856 - 46,690,240 (-)NCBIPanPan1.1PanPan1.1panPan2
IGFBP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1161,021,855 - 1,027,604 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl161,021,972 - 1,026,392 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha161,797,939 - 1,804,689 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0161,008,571 - 1,015,327 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl161,008,253 - 1,015,330 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.116999,220 - 1,005,969 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.016934,846 - 941,592 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.016233,123 - 239,875 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Igfbp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118101,299,235 - 101,306,540 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647820,510,137 - 20,518,306 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647820,511,490 - 20,518,251 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGFBP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1850,003,022 - 50,010,690 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11850,002,921 - 50,009,425 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21854,851,168 - 54,855,699 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap18q24NCBI
IGFBP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12112,905,309 - 12,914,199 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2112,905,280 - 12,914,205 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660629,622,694 - 9,631,602 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Igfbp3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247406,877,348 - 6,886,512 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247406,878,818 - 6,886,512 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in IGFBP3
27 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7p13-12.3(chr7:44193369-46558381)x1 copy number loss See cases [RCV000052316] Chr7:44193369..46558381 [GRCh38]
Chr7:44232968..46597979 [GRCh37]
Chr7:44199493..46564504 [NCBI36]
Chr7:7p13-12.3		 pathogenic
GRCh38/hg38 7p14.3-q11.21(chr7:33328312-62377476)x3 copy number gain See cases [RCV000053532] Chr7:33328312..62377476 [GRCh38]
Chr7:33367924..61831899 [GRCh37]
Chr7:33334449..61469334 [NCBI36]
Chr7:7p14.3-q11.21		 pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7p13-12.1(chr7:44571949-53699760)x1 copy number loss See cases [RCV000134973] Chr7:44571949..53699760 [GRCh38]
Chr7:44611548..53767453 [GRCh37]
Chr7:44578073..53734947 [NCBI36]
Chr7:7p13-12.1		 pathogenic
GRCh38/hg38 7p14.1-11.2(chr7:40534157-56107122)x1 copy number loss See cases [RCV000136092] Chr7:40534157..56107122 [GRCh38]
Chr7:40573756..56174815 [GRCh37]
Chr7:40540281..56142309 [NCBI36]
Chr7:7p14.1-11.2		 pathogenic
GRCh38/hg38 7p14.1-12.1(chr7:40020598-50543500)x1 copy number loss See cases [RCV000136904] Chr7:40020598..50543500 [GRCh38]
Chr7:40060197..50611198 [GRCh37]
Chr7:40026722..50578692 [NCBI36]
Chr7:7p14.1-12.1		 pathogenic
GRCh38/hg38 7p14.1-12.3(chr7:37303478-48660738)x1 copy number loss See cases [RCV000137139] Chr7:37303478..48660738 [GRCh38]
Chr7:37343082..48700334 [GRCh37]
Chr7:37309607..48670880 [NCBI36]
Chr7:7p14.1-12.3		 pathogenic
TMEM106B-BRAF fusion deletion Pleomorphic xanthoastrocytoma [RCV000454357] Chr7:12258147..140494267 [GRCh37]
Chr7:7p21.3-q34		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p14.1-12.3(chr7:40350383-47034422)x1 copy number loss See cases [RCV000446941] Chr7:40350383..47034422 [GRCh37]
Chr7:7p14.1-12.3		 pathogenic
GRCh37/hg19 7p21.3-12.1(chr7:11048840-52863626)x3 copy number gain See cases [RCV000512091] Chr7:11048840..52863626 [GRCh37]
Chr7:7p21.3-12.1		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
NM_000598.5(IGFBP3):c.404-8G>A single nucleotide variant not provided [RCV000975150] Chr7:45917447 [GRCh38]
Chr7:45957046 [GRCh37]
Chr7:7p12.3		 benign
NM_000598.5(IGFBP3):c.700G>A (p.Gly234Ser) single nucleotide variant not provided [RCV000888729] Chr7:45916598 [GRCh38]
Chr7:45956197 [GRCh37]
Chr7:7p12.3		 benign
NM_000598.5(IGFBP3):c.582C>T (p.Ser194=) single nucleotide variant not provided [RCV000911914] Chr7:45917261 [GRCh38]
Chr7:45956860 [GRCh37]
Chr7:7p12.3		 benign
GRCh37/hg19 7p12.3(chr7:45895448-46380286)x3 copy number gain not provided [RCV001005947] Chr7:45895448..46380286 [GRCh37]
Chr7:7p12.3		 uncertain significance
GRCh37/hg19 7p14.1-12.3(chr7:41124364-47945566) copy number loss Syndactyly [RCV001352654] Chr7:41124364..47945566 [GRCh37]
Chr7:7p14.1-12.3		 pathogenic
GRCh37/hg19 7p13-12.2(chr7:43341583-50171623) copy number loss Intracranial hemorrhage [RCV001352658] Chr7:43341583..50171623 [GRCh37]
Chr7:7p13-12.2		 pathogenic
Single allele complex Ring chromosome 7 [RCV002280646] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p14.1-12.2(chr7:40778439-50228656) copy number loss not specified [RCV002053688] Chr7:40778439..50228656 [GRCh37]
Chr7:7p14.1-12.2		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:56604613-96692931)x1 copy number loss See cases [RCV002287832] Chr7:56604613..96692931 [GRCh37]
Chr7:7p22.3-q36.3		 uncertain significance
NM_000598.5(IGFBP3):c.61G>T (p.Gly21Trp) single nucleotide variant not specified [RCV004078520] Chr7:45921080 [GRCh38]
Chr7:45960679 [GRCh37]
Chr7:7p12.3		 uncertain significance
NM_000598.5(IGFBP3):c.193C>T (p.Pro65Ser) single nucleotide variant not specified [RCV004113547] Chr7:45920948 [GRCh38]
Chr7:45960547 [GRCh37]
Chr7:7p12.3		 uncertain significance
NM_000598.5(IGFBP3):c.28G>T (p.Ala10Ser) single nucleotide variant not specified [RCV004203974] Chr7:45921113 [GRCh38]
Chr7:45960712 [GRCh37]
Chr7:7p12.3		 uncertain significance
NM_000598.5(IGFBP3):c.116G>A (p.Arg39His) single nucleotide variant not specified [RCV004146884] Chr7:45921025 [GRCh38]
Chr7:45960624 [GRCh37]
Chr7:7p12.3		 uncertain significance
NM_000598.5(IGFBP3):c.776G>A (p.Arg259Gln) single nucleotide variant not specified [RCV004110335] Chr7:45914920 [GRCh38]
Chr7:45954519 [GRCh37]
Chr7:7p12.3		 uncertain significance
NM_000598.5(IGFBP3):c.851A>C (p.His284Pro) single nucleotide variant not specified [RCV004179539] Chr7:45914845 [GRCh38]
Chr7:45954444 [GRCh37]
Chr7:7p12.3		 uncertain significance
NM_000598.5(IGFBP3):c.478G>C (p.Val160Leu) single nucleotide variant not specified [RCV004265369] Chr7:45917365 [GRCh38]
Chr7:45956964 [GRCh37]
Chr7:7p12.3		 uncertain significance
NM_000598.5(IGFBP3):c.349G>A (p.Ala117Thr) single nucleotide variant not specified [RCV004272061] Chr7:45920792 [GRCh38]
Chr7:45960391 [GRCh37]
Chr7:7p12.3		 uncertain significance
NM_000598.5(IGFBP3):c.400C>T (p.Pro134Ser) single nucleotide variant not specified [RCV004365470] Chr7:45920741 [GRCh38]
Chr7:45960340 [GRCh37]
Chr7:7p12.3		 uncertain significance
NM_000598.5(IGFBP3):c.22C>G (p.Leu8Val) single nucleotide variant not specified [RCV004334998] Chr7:45921119 [GRCh38]
Chr7:45960718 [GRCh37]
Chr7:7p12.3		 uncertain significance
GRCh37/hg19 7p14.1-12.3(chr7:42516660-46202495)x1 copy number loss not provided [RCV003482956] Chr7:42516660..46202495 [GRCh37]
Chr7:7p14.1-12.3		 pathogenic
NC_000007.14:g.45043702_46521017delins[AGAAGGAAATTT;45310743_46521014;45043709_45310738inv] indel Cerebral cavernous malformation 2 [RCV003988183] Chr7:45043702..46521017 [GRCh38]
Chr7:7p13-12.3		 pathogenic
NC_000007.13:g.(?_43810758)_(45977174_?)del deletion not provided [RCV004578545] Chr7:43810758..45977174 [GRCh37]
Chr7:7p13-12.3		 uncertain significance
NM_000598.5(IGFBP3):c.557A>T (p.Tyr186Phe) single nucleotide variant not specified [RCV004627750] Chr7:45917286 [GRCh38]
Chr7:45956885 [GRCh37]
Chr7:7p12.3		 uncertain significance
NM_000598.5(IGFBP3):c.11C>T (p.Ala4Val) single nucleotide variant not specified [RCV004627751] Chr7:45921130 [GRCh38]
Chr7:45960729 [GRCh37]
Chr7:7p12.3		 uncertain significance
NM_000598.5(IGFBP3):c.698G>T (p.Arg233Met) single nucleotide variant not specified [RCV004926623] Chr7:45916600 [GRCh38]
Chr7:45956199 [GRCh37]
Chr7:7p12.3		 uncertain significance
NM_000598.5(IGFBP3):c.29C>G (p.Ala10Gly) single nucleotide variant not specified [RCV004933640] Chr7:45921112 [GRCh38]
Chr7:45960711 [GRCh37]
Chr7:7p12.3		 uncertain significance
NM_000598.5(IGFBP3):c.256G>C (p.Glu86Gln) single nucleotide variant not specified [RCV005349825] Chr7:45920885 [GRCh38]
Chr7:45960484 [GRCh37]
Chr7:7p12.3		 uncertain significance
NC_000007.13:g.(20954043_21001537)_(114528369_114556605)inv inversion Childhood apraxia of speech [RCV000234948] Chr7:21001537..114528369 [GRCh37]
Chr7:7p15.3-q31.1		 pathogenic
NM_000598.5(IGFBP3):c.592C>G (p.Gln198Glu) single nucleotide variant not specified [RCV004335075] Chr7:45917251 [GRCh38]
Chr7:45956850 [GRCh37]
Chr7:7p12.3		 uncertain significance
NM_000598.5(IGFBP3):c.689T>G (p.Leu230Arg) single nucleotide variant not specified [RCV004926624] Chr7:45916609 [GRCh38]
Chr7:45956208 [GRCh37]
Chr7:7p12.3		 uncertain significance
NM_000598.5(IGFBP3):c.701G>A (p.Gly234Asp) single nucleotide variant not specified [RCV005349824] Chr7:45916597 [GRCh38]
Chr7:45956196 [GRCh37]
Chr7:7p12.3		 uncertain significance
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:2033
Count of miRNA genes:826
Interacting mature miRNAs:941
Transcripts:ENST00000275521, ENST00000381083, ENST00000381086, ENST00000417621, ENST00000428530, ENST00000448817, ENST00000460209, ENST00000460477, ENST00000465642
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
597049682GWAS1145756_HBMI-adjusted waist-hip ratio QTL GWAS1145756 (human)2e-09body size trait (VT:0100005)waist to hip ratio (WHR) (CMO:0000020)74591543045915431Human
597309852GWAS1405926_HAgents acting on the renin-angiotensin system use measurement QTL GWAS1405926 (human)2e-08Agents acting on the renin-angiotensin system use measurement74591543045915431Human
1559132SAPOB3_HSerum apolipoprotein B level QTL 3 (human)20.4Apolipoprotein levelapolipoprotein B73289107458891074Human
597018649GWAS1114723_HBMI-adjusted waist circumference QTL GWAS1114723 (human)4e-15body size trait (VT:0100005)74592031845920319Human
597241687GWAS1337761_HIGF-1 measurement QTL GWAS1337761 (human)2e-23IGF-1 measurementblood insulin-like growth factor 1 level (CMO:0001297)74591737045917371Human
597317524GWAS1413598_Hdiastolic blood pressure QTL GWAS1413598 (human)1e-11arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)74592104645921047Human
2289453BW297_HBody weight QTL 297 (human)3.83Body weightbody mass index72334946449349464Human
597303049GWAS1399123_HSLIT and NTRK-like protein 1 measurement QTL GWAS1399123 (human)3e-36SLIT and NTRK-like protein 1 measurement74591645145916452Human
597327439GWAS1423513_Hcoronary artery calcification QTL GWAS1423513 (human)5e-10coronary artery integrity trait (VT:0010746)74592104645921047Human
597179651GWAS1275725_Hinsulin-like growth factor-binding protein 3 measurement QTL GWAS1275725 (human)8e-78insulin-like growth factor-binding protein 3 measurement74592104645921047Human
596963593GWAS1083112_HBMI-adjusted waist circumference QTL GWAS1083112 (human)2e-09BMI-adjusted waist circumference74592031845920319Human
597179653GWAS1275727_Hinsulin-like growth factor-binding protein 3 measurement QTL GWAS1275727 (human)1e-116insulin-like growth factor-binding protein 3 measurement74591486645914867Human
2302781MAMTS16_HMammary tumor susceptibility QTL 16 (human)0.033Mammary tumor susceptibility73634937162349371Human
597288071GWAS1384145_Hsystolic blood pressure QTL GWAS1384145 (human)1e-09arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)74591992745919930Human
597312965GWAS1409039_Hcortical thickness QTL GWAS1409039 (human)3e-13cerebral cortex morphology trait (VT:0000788)74592104645921047Human
1558711BP56_HBlood pressure QTL 56 (human)2.240.000002Blood pressuresystolic73634937162349371Human
596967088GWAS1086607_Hdiastolic blood pressure QTL GWAS1086607 (human)1e-11diastolic blood pressure74592104645921047Human
597586874GWAS1643734_Hdiastolic blood pressure change measurement QTL GWAS1643734 (human)4e-15arterial blood pressure trait (VT:2000000)change in diastolic blood pressure (CMO:0001016)74592104645921047Human
407079206GWAS728182_Hdiastolic blood pressure QTL GWAS728182 (human)1e-19arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)74592104645921047Human
597179645GWAS1275719_Hprotein measurement QTL GWAS1275719 (human)3e-48protein amount (VT:0010120)74592104645921047Human
597141183GWAS1237257_HIGFBP-3 measurement QTL GWAS1237257 (human)0.0000001IGFBP-3 measurement74592104645921047Human
597495284GWAS1591358_Hsystolic blood pressure QTL GWAS1591358 (human)2e-08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)74592031845920319Human
596954558GWAS1074077_Hwaist-hip ratio QTL GWAS1074077 (human)2e-09waist-hip ratio74591543045915431Human
597171252GWAS1267326_Hnutritionally-regulated adipose and cardiac enriched protein homolog measurement QTL GWAS1267326 (human)1e-182nutritionally-regulated adipose and cardiac enriched protein homolog measurement74592104645921047Human
597301098GWAS1397172_Hinsulin-like growth factor-binding protein 3 measurement QTL GWAS1397172 (human)1e-19insulin-like growth factor-binding protein 3 measurement74591486645914867Human
597596204GWAS1653064_Hdiastolic blood pressure change measurement QTL GWAS1653064 (human)6e-24arterial blood pressure trait (VT:2000000)change in diastolic blood pressure (CMO:0001016)74592104645921047Human
597327598GWAS1423672_Hcoronary artery calcification QTL GWAS1423672 (human)0.000004coronary artery integrity trait (VT:0010746)74592104645921047Human
597266849GWAS1362923_HIGF-1 measurement QTL GWAS1362923 (human)1e-17IGF-1 measurementblood insulin-like growth factor 1 level (CMO:0001297)74592104645921047Human
597120942GWAS1217016_HIGF-1 measurement QTL GWAS1217016 (human)7e-21IGF-1 measurementblood insulin-like growth factor 1 level (CMO:0001297)74591658645916587Human
597266848GWAS1362922_HIGFBP-3 measurement QTL GWAS1362922 (human)3e-52IGFBP-3 measurement74592104645921047Human
597120941GWAS1217015_HIGF-1 measurement QTL GWAS1217015 (human)4e-11IGF-1 measurementblood insulin-like growth factor 1 level (CMO:0001297)74591492045914921Human
596971310GWAS1090829_Hsystolic blood pressure QTL GWAS1090829 (human)1e-09systolic blood pressure74591992745919930Human
597324070GWAS1420144_HIGFBP-3 measurement QTL GWAS1420144 (human)1e-49IGFBP-3 measurement74592104645921047Human
597393893GWAS1489967_Happendicular lean mass QTL GWAS1489967 (human)2e-09body lean mass (VT:0010483)74592031845920319Human

Markers in Region
STS-M35878  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37745,951,909 - 45,952,121UniSTSGRCh37
Build 36745,918,434 - 45,918,646RGDNCBI36
Celera746,050,826 - 46,051,038RGD
Cytogenetic Map7p13-p12UniSTS
HuRef745,836,864 - 45,837,076UniSTS
CRA_TCAGchr7v2745,991,238 - 45,991,450UniSTS
GeneMap99-GB4 RH Map7216.65UniSTS
NCBI RH Map7670.1UniSTS
D7S2379  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37745,952,067 - 45,952,242UniSTSGRCh37
Build 36745,918,592 - 45,918,767RGDNCBI36
Celera746,050,984 - 46,051,159RGD
Cytogenetic Map7p13-p12UniSTS
HuRef745,837,022 - 45,837,197UniSTS
CRA_TCAGchr7v2745,991,396 - 45,991,571UniSTS
Whitehead-YAC Contig Map7 UniSTS
D7S2146E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37745,956,164 - 45,956,896UniSTSGRCh37
Build 36745,922,689 - 45,923,421RGDNCBI36
Celera746,055,080 - 46,055,812RGD
Cytogenetic Map7p13-p12UniSTS
HuRef745,841,118 - 45,841,850UniSTS
CRA_TCAGchr7v2745,995,491 - 45,996,223UniSTS
D7S2833  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37745,953,043 - 45,953,387UniSTSGRCh37
Build 36745,919,568 - 45,919,912RGDNCBI36
Celera746,051,960 - 46,052,304RGD
Cytogenetic Map7p13-p12UniSTS
HuRef745,837,998 - 45,838,342UniSTS
CRA_TCAGchr7v2745,992,372 - 45,992,716UniSTS
Whitehead-YAC Contig Map7 UniSTS
IGFBP3-5'1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37745,961,361 - 45,962,020UniSTSGRCh37
Build 36745,927,886 - 45,928,545RGDNCBI36
Celera746,060,275 - 46,060,934RGD
Cytogenetic Map7p13-p12UniSTS
HuRef745,846,314 - 45,846,973UniSTS
CRA_TCAGchr7v2746,000,688 - 46,001,347UniSTS
IGFBP3-X2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37745,956,719 - 45,957,110UniSTSGRCh37
Build 36745,923,244 - 45,923,635RGDNCBI36
Celera746,055,635 - 46,056,026RGD
Cytogenetic Map7p13-p12UniSTS
HuRef745,841,673 - 45,842,064UniSTS
CRA_TCAGchr7v2745,996,046 - 45,996,437UniSTS
IGFBP3-X3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37745,956,001 - 45,956,470UniSTSGRCh37
Build 36745,922,526 - 45,922,995RGDNCBI36
Celera746,054,917 - 46,055,386RGD
Cytogenetic Map7p13-p12UniSTS
HuRef745,840,955 - 45,841,424UniSTS
CRA_TCAGchr7v2745,995,328 - 45,995,797UniSTS
IGFBP3-X4.2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37745,953,463 - 45,954,122UniSTSGRCh37
Build 36745,919,988 - 45,920,647RGDNCBI36
Celera746,052,380 - 46,053,039RGD
Cytogenetic Map7p13-p12UniSTS
HuRef745,838,418 - 45,839,077UniSTS
CRA_TCAGchr7v2745,992,792 - 45,993,451UniSTS
IGFBP3-X4.3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37745,952,939 - 45,953,583UniSTSGRCh37
Build 36745,919,464 - 45,920,108RGDNCBI36
Celera746,051,856 - 46,052,500RGD
Cytogenetic Map7p13-p12UniSTS
HuRef745,837,894 - 45,838,538UniSTS
CRA_TCAGchr7v2745,992,268 - 45,992,912UniSTS
IGFBP3-X4.4  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37745,952,393 - 45,953,038UniSTSGRCh37
Build 36745,918,918 - 45,919,563RGDNCBI36
Celera746,051,310 - 46,051,955RGD
Cytogenetic Map7p13-p12UniSTS
HuRef745,837,348 - 45,837,993UniSTS
CRA_TCAGchr7v2745,991,722 - 45,992,367UniSTS
IGFBP3-X4.5  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37745,951,904 - 45,952,509UniSTSGRCh37
Build 36745,918,429 - 45,919,034RGDNCBI36
Celera746,050,821 - 46,051,426RGD
Cytogenetic Map7p13-p12UniSTS
HuRef745,836,859 - 45,837,464UniSTS
CRA_TCAGchr7v2745,991,233 - 45,991,838UniSTS
IGFBP3_1859  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37745,952,467 - 45,953,282UniSTSGRCh37
Build 36745,918,992 - 45,919,807RGDNCBI36
Celera746,051,384 - 46,052,199RGD
HuRef745,837,422 - 45,838,237UniSTS
CRA_TCAGchr7v2745,991,796 - 45,992,611UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1204 2417 2788 2234 4942 1717 2325 4 621 1757 462 2267 7094 6280 47 3706 849 1735 1594 171

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_011508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001013398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047420325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054358119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC091524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF370418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI142967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK055632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK056274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK091706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK091745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK092447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK095408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK095864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK095869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK095900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK095907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK095974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK095991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK097201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK122873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK123735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK125224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK127537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK130884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL540642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AU102436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC064987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX640961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH236958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ301819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ884396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ884397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ884398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M31159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M35878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S56205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X64875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000275521   ⟹   ENSP00000275521
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl745,912,598 - 45,921,274 (-)Ensembl
Ensembl Acc Id: ENST00000381083   ⟹   ENSP00000370473
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl745,912,245 - 45,921,272 (-)Ensembl
Ensembl Acc Id: ENST00000381086   ⟹   ENSP00000370476
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl745,912,245 - 45,921,272 (-)Ensembl
Ensembl Acc Id: ENST00000417621   ⟹   ENSP00000399116
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl745,914,470 - 45,917,426 (-)Ensembl
Ensembl Acc Id: ENST00000428530   ⟹   ENSP00000390298
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl745,914,101 - 45,917,397 (-)Ensembl
Ensembl Acc Id: ENST00000448817   ⟹   ENSP00000389668
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl745,916,572 - 45,921,874 (-)Ensembl
Ensembl Acc Id: ENST00000460209
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl745,913,773 - 45,915,325 (-)Ensembl
Ensembl Acc Id: ENST00000460477
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl745,916,996 - 45,920,867 (-)Ensembl
Ensembl Acc Id: ENST00000465642
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl745,916,621 - 45,920,415 (-)Ensembl
Ensembl Acc Id: ENST00000613132   ⟹   ENSP00000477772
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl745,912,245 - 45,921,272 (-)Ensembl
Ensembl Acc Id: ENST00000615754   ⟹   ENSP00000480717
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl745,914,820 - 45,921,140 (-)Ensembl
RefSeq Acc Id: NM_000598   ⟹   NP_000589
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38745,912,245 - 45,921,272 (-)NCBI
GRCh37745,951,844 - 45,960,871 (-)ENTREZGENE
Build 36745,918,369 - 45,927,396 (-)NCBI Archive
HuRef745,836,799 - 45,845,824 (-)ENTREZGENE
CHM1_1745,956,047 - 45,965,072 (-)NCBI
T2T-CHM13v2.0746,073,961 - 46,082,986 (-)NCBI
CRA_TCAGchr7v2745,991,173 - 46,000,198 (-)ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001013398   ⟹   NP_001013416
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38745,912,245 - 45,921,272 (-)NCBI
GRCh37745,951,844 - 45,960,871 (-)ENTREZGENE
Build 36745,918,369 - 45,927,396 (-)NCBI Archive
HuRef745,836,799 - 45,845,824 (-)ENTREZGENE
CHM1_1745,956,047 - 45,965,072 (-)NCBI
T2T-CHM13v2.0746,073,961 - 46,082,986 (-)NCBI
CRA_TCAGchr7v2745,991,173 - 46,000,198 (-)ENTREZGENE
Sequence:
RefSeq Acc Id: XM_047420325   ⟹   XP_047276281
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38745,914,252 - 45,921,272 (-)NCBI
RefSeq Acc Id: XM_054358119   ⟹   XP_054214094
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0746,075,966 - 46,082,986 (-)NCBI
Protein Sequences
Protein RefSeqs NP_000589 (Get FASTA)   NCBI Sequence Viewer  
  NP_001013416 (Get FASTA)   NCBI Sequence Viewer  
  XP_047276281 (Get FASTA)   NCBI Sequence Viewer  
  XP_054214094 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA52541 (Get FASTA)   NCBI Sequence Viewer  
  AAA52706 (Get FASTA)   NCBI Sequence Viewer  
  AAH00013 (Get FASTA)   NCBI Sequence Viewer  
  AAH18962 (Get FASTA)   NCBI Sequence Viewer  
  AAH64987 (Get FASTA)   NCBI Sequence Viewer  
  AAQ15254 (Get FASTA)   NCBI Sequence Viewer  
  AAS07554 (Get FASTA)   NCBI Sequence Viewer  
  ABB96247 (Get FASTA)   NCBI Sequence Viewer  
  ABI63363 (Get FASTA)   NCBI Sequence Viewer  
  ABI63364 (Get FASTA)   NCBI Sequence Viewer  
  ABI63365 (Get FASTA)   NCBI Sequence Viewer  
  BAC87023 (Get FASTA)   NCBI Sequence Viewer  
  BAG38033 (Get FASTA)   NCBI Sequence Viewer  
  BAG51662 (Get FASTA)   NCBI Sequence Viewer  
  BAG52153 (Get FASTA)   NCBI Sequence Viewer  
  BAG52402 (Get FASTA)   NCBI Sequence Viewer  
  BAG52410 (Get FASTA)   NCBI Sequence Viewer  
  BAG52553 (Get FASTA)   NCBI Sequence Viewer  
  BAG53151 (Get FASTA)   NCBI Sequence Viewer  
  BAG53162 (Get FASTA)   NCBI Sequence Viewer  
  BAG53182 (Get FASTA)   NCBI Sequence Viewer  
  BAG53189 (Get FASTA)   NCBI Sequence Viewer  
  BAG53771 (Get FASTA)   NCBI Sequence Viewer  
  BAG53948 (Get FASTA)   NCBI Sequence Viewer  
  BAG54169 (Get FASTA)   NCBI Sequence Viewer  
  BAG60115 (Get FASTA)   NCBI Sequence Viewer  
  BAG60419 (Get FASTA)   NCBI Sequence Viewer  
  CAA46087 (Get FASTA)   NCBI Sequence Viewer  
  EAL23801 (Get FASTA)   NCBI Sequence Viewer  
  EAW61025 (Get FASTA)   NCBI Sequence Viewer  
  EAW61026 (Get FASTA)   NCBI Sequence Viewer  
  EAW61027 (Get FASTA)   NCBI Sequence Viewer  
  EAW61028 (Get FASTA)   NCBI Sequence Viewer  
  EAW61029 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000370473
  ENSP00000370473.4
  ENSP00000477772
  ENSP00000477772.2
GenBank Protein P17936 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_000589   ⟸   NM_000598
- Peptide Label: isoform b precursor
- UniProtKB: Q6P1M6 (UniProtKB/Swiss-Prot),   Q2V509 (UniProtKB/Swiss-Prot),   D3DVM0 (UniProtKB/Swiss-Prot),   A4D2F5 (UniProtKB/Swiss-Prot),   Q9UCL4 (UniProtKB/Swiss-Prot),   P17936 (UniProtKB/Swiss-Prot),   B4DN53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001013416   ⟸   NM_001013398
- Peptide Label: isoform a precursor
- UniProtKB: B4DN53 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000390298   ⟸   ENST00000428530
Ensembl Acc Id: ENSP00000477772   ⟸   ENST00000613132
Ensembl Acc Id: ENSP00000399116   ⟸   ENST00000417621
Ensembl Acc Id: ENSP00000480717   ⟸   ENST00000615754
Ensembl Acc Id: ENSP00000275521   ⟸   ENST00000275521
Ensembl Acc Id: ENSP00000389668   ⟸   ENST00000448817
Ensembl Acc Id: ENSP00000370476   ⟸   ENST00000381086
Ensembl Acc Id: ENSP00000370473   ⟸   ENST00000381083
RefSeq Acc Id: XP_047276281   ⟸   XM_047420325
- Peptide Label: isoform X1
- UniProtKB: Q6P1M6 (UniProtKB/Swiss-Prot),   Q2V509 (UniProtKB/Swiss-Prot),   P17936 (UniProtKB/Swiss-Prot),   D3DVM0 (UniProtKB/Swiss-Prot),   A4D2F5 (UniProtKB/Swiss-Prot),   Q9UCL4 (UniProtKB/Swiss-Prot),   B4DN53 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054214094   ⟸   XM_054358119
- Peptide Label: isoform X1
- UniProtKB: B4DN53 (UniProtKB/TrEMBL)
Protein Domains
IGFBP N-terminal   Thyroglobulin type-1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17936-F1-model_v2 AlphaFold P17936 1-291 view protein structure

Promoters
RGD ID:6805798
Promoter ID:HG_KWN:57313
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:OTTHUMT00000340051
Position:
Human AssemblyChrPosition (strand)Source
Build 36745,921,046 - 45,921,546 (-)MPROMDB
RGD ID:7210547
Promoter ID:EPDNEW_H11019
Type:initiation region
Name:IGFBP3_1
Description:insulin like growth factor binding protein 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38745,921,272 - 45,921,332EPDNEW
RGD ID:6805801
Promoter ID:HG_KWN:57314
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3
Transcripts:OTTHUMT00000340052,   OTTHUMT00000340053
Position:
Human AssemblyChrPosition (strand)Source
Build 36745,923,196 - 45,924,097 (-)MPROMDB
RGD ID:6805549
Promoter ID:HG_KWN:57315
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour,   HeLa_S3
Transcripts:ENST00000381086,   NM_001013398,   OTTHUMT00000251356,   OTTHUMT00000340036,   OTTHUMT00000340048,   OTTHUMT00000340049,   OTTHUMT00000340050,   UC003TNQ.1,   UC003TNT.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36745,926,974 - 45,927,474 (-)MPROMDB
RGD ID:6850626
Promoter ID:EP73107
Type:single initiation site
Name:HS_IGFBP3
Description:Insulin-like growth factor binding protein 3.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 36745,927,396 - 45,927,456EPD

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:5472 AgrOrtholog
COSMIC IGFBP3 COSMIC
Ensembl Genes ENSG00000146674 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000381083 ENTREZGENE
  ENST00000381083.9 UniProtKB/Swiss-Prot
  ENST00000613132 ENTREZGENE
  ENST00000613132.5 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.40.20 UniProtKB/Swiss-Prot
  4.10.800.10 UniProtKB/Swiss-Prot
GTEx ENSG00000146674 GTEx
HGNC ID HGNC:5472 ENTREZGENE
Human Proteome Map IGFBP3 Human Proteome Map
InterPro Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  IGFBP-3 UniProtKB/Swiss-Prot
  IGFBP-like UniProtKB/Swiss-Prot
  IGFBP_1-6_chordata UniProtKB/Swiss-Prot
  Insulin_GF-bd_Cys-rich_CS UniProtKB/Swiss-Prot
  Thyroglobulin_1 UniProtKB/Swiss-Prot
  Thyroglobulin_1_sf UniProtKB/Swiss-Prot
KEGG Report hsa:3486 UniProtKB/Swiss-Prot
NCBI Gene 3486 ENTREZGENE
OMIM 146732 OMIM
PANTHER INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN UniProtKB/Swiss-Prot
  PTHR11551:SF3 UniProtKB/Swiss-Prot
Pfam IGFBP UniProtKB/Swiss-Prot
  Thyroglobulin_1 UniProtKB/Swiss-Prot
PharmGKB IGFBP3 RGD, PharmGKB
PRINTS IGFBPFAMILY UniProtKB/Swiss-Prot
  IGFBPFAMILY3 UniProtKB/Swiss-Prot
PROSITE IGFBP_N_1 UniProtKB/Swiss-Prot
  IGFBP_N_2 UniProtKB/Swiss-Prot
  THYROGLOBULIN_1_1 UniProtKB/Swiss-Prot
  THYROGLOBULIN_1_2 UniProtKB/Swiss-Prot
SMART SM00121 UniProtKB/Swiss-Prot
  SM00211 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57184 UniProtKB/Swiss-Prot
  SSF57610 UniProtKB/Swiss-Prot
UniProt A4D2F5 ENTREZGENE
  A6XND0_HUMAN UniProtKB/TrEMBL
  B3KPF0_HUMAN UniProtKB/TrEMBL
  B3KWK7_HUMAN UniProtKB/TrEMBL
  B4DN53 ENTREZGENE, UniProtKB/TrEMBL
  C9JMX4_HUMAN UniProtKB/TrEMBL
  D3DVM0 ENTREZGENE
  H0Y485_HUMAN UniProtKB/TrEMBL
  H0Y5K2_HUMAN UniProtKB/TrEMBL
  IBP3_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q2V509 ENTREZGENE
  Q6P1M6 ENTREZGENE
  Q9UCL4 ENTREZGENE
UniProt Secondary A4D2F5 UniProtKB/Swiss-Prot
  D3DVM0 UniProtKB/Swiss-Prot
  Q2V509 UniProtKB/Swiss-Prot
  Q6P1M6 UniProtKB/Swiss-Prot
  Q9UCL4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-08 IGFBP3  insulin like growth factor binding protein 3  IGFBP3  insulin-like growth factor binding protein 3  Symbol and/or name change 5135510 APPROVED