Slc12a3 (solute carrier family 12, member 3) - Rat Genome Database

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Gene: Slc12a3 (solute carrier family 12, member 3) Mus musculus
Analyze
Symbol: Slc12a3
Name: solute carrier family 12, member 3
RGD ID: 735991
MGI Page MGI
Description: Enables sodium:chloride symporter activity. Involved in response to aldosterone; response to salt; and sodium ion transmembrane transport. Located in apical plasma membrane and cytosol. Is active in plasma membrane. Is expressed in metanephros. Used to study Gitelman syndrome. Human ortholog(s) of this gene implicated in Gitelman syndrome and essential hypertension. Orthologous to human SLC12A3 (solute carrier family 12 member 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI035291; Na-Cl symporter; NC; NCC; NCCT; solute carrier family 12 member 3; solute carrier family 12 member 3-like; thiazide-sensitive sodium-chloride cotransporter; TS; TSC
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39895,055,737 - 95,092,850 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl895,055,829 - 95,092,842 (+)EnsemblGRCm39 Ensembl
GRCm38894,329,109 - 94,366,222 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl894,329,201 - 94,366,214 (+)EnsemblGRCm38mm10GRCm38
MGSCv37896,853,108 - 96,890,122 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36897,218,355 - 97,255,092 (+)NCBIMGSCv36mm8
Celera898,660,930 - 98,697,944 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map846.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apical plasma membrane  (IBA,IDA,ISO)
cytosol  (IDA)
extracellular exosome  (IEA,ISO)
plasma membrane  (IDA,ISO)
vesicle  (ISO)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney. Gamba G, etal., J Biol Chem 1994 Jul 1;269(26):17713-22.
2. The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics. Matayoshi T, etal., Hypertens Res. 2004 Nov;27(11):821-33.
3. G2736A polymorphism of thiazide-sensitive Na-Cl cotransporter gene predisposes to hypertension in young women. Matsuo A, etal., J Hypertens. 2004 Nov;22(11):2123-7.
4. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. Mouse chromosomal location of three epithelial sodium channel subunit genes and an apical sodium chloride cotransporter gene. Pathak BG, etal., Genomics 1996 Apr 1;33(1):124-7.
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Gitelman syndrome: genetic and expression analysis of the thiazide-sensitive sodium-chloride transporter in blood cells. Riancho JA, etal., Nephrol Dial Transplant. 2006 Jan;21(1):217-20. Epub 2005 Oct 12.
15. Sodium retention in rats with liver cirrhosis is associated with increased renal abundance of NaCl cotransporter (NCC). Yu Z, etal., Nephrol Dial Transplant. 2005 Sep;20(9):1833-41. Epub 2005 Jun 14.
Additional References at PubMed
PMID:9786924   PMID:10349636   PMID:10516289   PMID:11042159   PMID:11076861   PMID:11158268   PMID:11217851   PMID:11423561   PMID:11729236   PMID:12388412   PMID:12388426   PMID:12477932  
PMID:14576148   PMID:14681479   PMID:15068971   PMID:15339977   PMID:15489334   PMID:15550389   PMID:15824853   PMID:15902302   PMID:16049112   PMID:16141072   PMID:16141073   PMID:16275913  
PMID:16434571   PMID:16602821   PMID:16788137   PMID:16816365   PMID:16964266   PMID:17036046   PMID:17079272   PMID:17314325   PMID:17452023   PMID:18077438   PMID:18391953   PMID:18485340  
PMID:18800028   PMID:19008908   PMID:19060336   PMID:19240212   PMID:19323993   PMID:19401467   PMID:19470686   PMID:19521566   PMID:19570885   PMID:19633012   PMID:19690383   PMID:19844087  
PMID:19855135   PMID:20389022   PMID:20392800   PMID:20921400   PMID:20944551   PMID:20978075   PMID:21131289   PMID:21267068   PMID:21270765   PMID:21321328   PMID:21343368   PMID:21397062  
PMID:21521738   PMID:21677750   PMID:21852580   PMID:21873635   PMID:21907141   PMID:21909387   PMID:21963515   PMID:21972418   PMID:22005268   PMID:22027832   PMID:22076439   PMID:22511595  
PMID:22718890   PMID:22846565   PMID:22847418   PMID:22977235   PMID:23348737   PMID:23360989   PMID:23362348   PMID:23362349   PMID:23447069   PMID:23482560   PMID:23555292   PMID:23665031  
PMID:23684652   PMID:23833262   PMID:24026181   PMID:24206662   PMID:24231659   PMID:24352504   PMID:24429824   PMID:24463702   PMID:24610784   PMID:24655003   PMID:24744442   PMID:24984877  
PMID:25071208   PMID:25168025   PMID:25401745   PMID:25565204   PMID:25587121   PMID:25651563   PMID:25885434   PMID:25893600   PMID:26099046   PMID:26279573   PMID:26511275   PMID:26721884  
PMID:26728390   PMID:26859289   PMID:26963391   PMID:27151921   PMID:27442254   PMID:27458135   PMID:27582101   PMID:27633993   PMID:27733368   PMID:27942049   PMID:28033128   PMID:28067240  
PMID:28334964   PMID:28341239   PMID:28527294   PMID:28535371   PMID:28646163   PMID:28719636   PMID:28750403   PMID:28847650   PMID:29113990   PMID:29212817   PMID:29310825   PMID:29384416  
PMID:29449453   PMID:29459093   PMID:29483574   PMID:29596840   PMID:29993276   PMID:30046000   PMID:30578077   PMID:31253651   PMID:31685872   PMID:32295826   PMID:32504627   PMID:32592815  
PMID:32657158   PMID:32715478   PMID:32956652   PMID:33486984   PMID:33737325   PMID:33859252   PMID:34174287   PMID:34499620   PMID:34667084   PMID:35341793   PMID:35870644   PMID:35877077  
PMID:36370249   PMID:36482059   PMID:36522157   PMID:37727504   PMID:38653356   PMID:38692273   PMID:38906145   PMID:39009564  


Genomics

Comparative Map Data
Slc12a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39895,055,737 - 95,092,850 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl895,055,829 - 95,092,842 (+)EnsemblGRCm39 Ensembl
GRCm38894,329,109 - 94,366,222 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl894,329,201 - 94,366,214 (+)EnsemblGRCm38mm10GRCm38
MGSCv37896,853,108 - 96,890,122 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36897,218,355 - 97,255,092 (+)NCBIMGSCv36mm8
Celera898,660,930 - 98,697,944 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map846.46NCBI
SLC12A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381656,865,207 - 56,915,850 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1656,865,207 - 56,915,850 (+)EnsemblGRCh38hg38GRCh38
GRCh371656,899,119 - 56,949,762 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361655,456,643 - 55,504,850 (+)NCBINCBI36Build 36hg18NCBI36
Build 341655,456,642 - 55,504,850NCBI
Celera1641,398,377 - 41,450,052 (+)NCBICelera
Cytogenetic Map16q13NCBI
HuRef1642,768,662 - 42,819,218 (+)NCBIHuRef
CHM1_11658,307,135 - 58,357,791 (+)NCBICHM1_1
T2T-CHM13v2.01662,661,526 - 62,712,168 (+)NCBIT2T-CHM13v2.0
Slc12a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81910,636,594 - 10,690,008 (-)NCBIGRCr8
mRatBN7.21910,630,651 - 10,679,250 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,631,393 - 10,669,091 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1910,594,046 - 10,632,542 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01911,360,884 - 11,399,380 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,647,871 - 10,686,368 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01911,106,033 - 11,144,674 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1911,106,033 - 11,144,641 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01911,084,193 - 11,122,657 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41911,070,329 - 11,109,634 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11911,075,156 - 11,114,460 (-)NCBI
Celera1910,518,752 - 10,557,092 (-)NCBICelera
Cytogenetic Map19p13-p12NCBI
Slc12a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543314,553,758 - 14,587,602 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543314,553,752 - 14,588,317 (+)NCBIChiLan1.0ChiLan1.0
SLC12A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21866,316,962 - 66,386,655 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11672,237,646 - 72,307,205 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01637,142,797 - 37,193,713 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11656,276,026 - 56,326,973 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1656,276,049 - 56,324,528 (+)Ensemblpanpan1.1panPan2
SLC12A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,413,737 - 59,449,129 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,413,828 - 59,449,081 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha256,042,573 - 56,077,948 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0259,952,797 - 59,988,344 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl259,952,888 - 59,988,297 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1256,783,974 - 56,819,378 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0257,791,053 - 57,826,469 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0258,685,512 - 58,720,937 (-)NCBIUU_Cfam_GSD_1.0
Slc12a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934950,512,705 - 50,545,228 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364759,044,106 - 9,076,307 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364759,044,099 - 9,076,301 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC12A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl618,844,600 - 18,885,476 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1618,844,752 - 18,885,497 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SLC12A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1542,808,773 - 42,877,714 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl542,811,597 - 42,862,002 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604733,488,318 - 33,536,531 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc12a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474629,098,254 - 29,132,752 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474629,087,867 - 29,132,793 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc12a3
3105 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:128
Count of miRNA genes:119
Interacting mature miRNAs:124
Transcripts:ENSMUST00000034218
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined866326836100326976Mouse
14696809Rbcn3_mrod bipolar cell number 3 (mouse)895056628102856632Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined876411976110412125Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined866084397100084549Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined871032003105032123Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined876411976110412125Mouse
1301766Desp1_mdespair 1 (mouse)Not determined885486208119486373Mouse
1301253Skmw2_mskeletal muscle weight 2 (mouse)Not determined886443553120443701Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871740461124622354Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6418673698186736Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86466617698666325Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)882345783116345783Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879808806113809031Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined876411976110412125Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined872122809106123021Mouse
10045619Heal14_mwound healing/regeneration 14 (mouse)Not determined886443553120443701Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86151347995513605Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871829531105829637Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873929123107929226Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)84016229795416226Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881819296115819296Mouse
1302049Heal1_mwound healing/regeneration 1 (mouse)Not determined886443553120443701Mouse
27226796Scvln16_msacral vertebrae length 2, 16 week (mouse)889726628130027694Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined871032003105032123Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)874126628126826739Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71740461124622354Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined879245241113245331Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined876402145110402251Mouse

Markers in Region
AI035291  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38894,358,561 - 94,358,651UniSTSGRCm38
MGSCv37896,882,461 - 96,882,551UniSTSGRCm37
Celera898,690,283 - 98,690,373UniSTS
Cytogenetic Map8C5UniSTS
cM Map845.0UniSTS
Whitehead/MRC_RH81149.47UniSTS
C78859  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38894,327,730 - 94,327,873UniSTSGRCm38
MGSCv37896,851,630 - 96,851,773UniSTSGRCm37
MGSCv37X21,529 - 21,672UniSTSGRCm37
Celera898,659,452 - 98,659,595UniSTS
Cytogenetic Map8C5UniSTS
cM Map845.0UniSTS
Whitehead/MRC_RH81157.79UniSTS
Slc12a3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C5UniSTS
cM Map846.46UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001205311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017312625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017312626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017312627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001778414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004934784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC128663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI647800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI882166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK085430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK085496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC022671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC038612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U61085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000034218   ⟹   ENSMUSP00000034218
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl895,055,829 - 95,092,842 (+)Ensembl
GRCm38.p6 Ensembl894,329,201 - 94,366,214 (+)Ensembl
Ensembl Acc Id: ENSMUST00000211905   ⟹   ENSMUSP00000148537
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl895,082,939 - 95,086,215 (+)Ensembl
GRCm38.p6 Ensembl894,356,311 - 94,359,587 (+)Ensembl
Ensembl Acc Id: ENSMUST00000211942
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl895,081,674 - 95,084,834 (+)Ensembl
GRCm38.p6 Ensembl894,355,046 - 94,358,206 (+)Ensembl
Ensembl Acc Id: ENSMUST00000212041
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl895,055,838 - 95,073,760 (+)Ensembl
GRCm38.p6 Ensembl894,329,210 - 94,347,132 (+)Ensembl
Ensembl Acc Id: ENSMUST00000212134   ⟹   ENSMUSP00000148455
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl895,055,833 - 95,086,561 (+)Ensembl
GRCm38.p6 Ensembl894,329,205 - 94,359,933 (+)Ensembl
Ensembl Acc Id: ENSMUST00000212632
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl895,079,081 - 95,081,843 (+)Ensembl
GRCm38.p6 Ensembl894,352,453 - 94,355,215 (+)Ensembl
Ensembl Acc Id: ENSMUST00000212915
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl895,072,443 - 95,076,813 (+)Ensembl
GRCm38.p6 Ensembl894,345,815 - 94,350,185 (+)Ensembl
RefSeq Acc Id: NM_001205311   ⟹   NP_001192240
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39895,055,836 - 95,092,850 (+)NCBI
GRCm38894,329,208 - 94,366,222 (+)NCBI
Celera898,660,930 - 98,697,944 (+)ENTREZGENE
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_019415   ⟹   NP_062288
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39895,055,836 - 95,092,850 (+)NCBI
GRCm38894,329,208 - 94,366,222 (+)NCBI
MGSCv37896,853,108 - 96,890,122 (+)RGD
Celera898,660,930 - 98,697,944 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017312625   ⟹   XP_017168114
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39895,055,739 - 95,092,850 (+)NCBI
GRCm38894,329,111 - 94,366,222 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017312626   ⟹   XP_017168115
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39895,055,739 - 95,092,850 (+)NCBI
GRCm38894,329,111 - 94,366,222 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017312627   ⟹   XP_017168116
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39895,055,739 - 95,070,786 (+)NCBI
GRCm38894,329,111 - 94,344,148 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001778414
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39895,055,737 - 95,082,977 (+)NCBI
GRCm38894,329,109 - 94,356,349 (+)NCBI
Sequence:
RefSeq Acc Id: XR_004934784
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39895,055,738 - 95,092,850 (+)NCBI
Sequence:
RefSeq Acc Id: NP_062288   ⟸   NM_019415
- Peptide Label: isoform 2
- UniProtKB: Q62439 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001192240   ⟸   NM_001205311
- Peptide Label: isoform 1
- UniProtKB: P59158 (UniProtKB/Swiss-Prot),   Q543E4 (UniProtKB/TrEMBL),   Q62439 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017168114   ⟸   XM_017312625
- Peptide Label: isoform X1
- UniProtKB: Q62439 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017168115   ⟸   XM_017312626
- Peptide Label: isoform X2
- UniProtKB: Q62439 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017168116   ⟸   XM_017312627
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSMUSP00000148537   ⟸   ENSMUST00000211905
Ensembl Acc Id: ENSMUSP00000034218   ⟸   ENSMUST00000034218
Ensembl Acc Id: ENSMUSP00000148455   ⟸   ENSMUST00000212134
Protein Domains
Amino acid permease N-terminal   Amino acid permease/ SLC12A   SLC12A transporter C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P59158-F1-model_v2 AlphaFold P59158 1-1002 view protein structure

Promoters
RGD ID:8667895
Promoter ID:EPDNEW_M11979
Type:multiple initiation site
Name:Slc12a3_1
Description:Mus musculus solute carrier family 12, member 3 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38894,329,210 - 94,329,270EPDNEW
RGD ID:6843719
Promoter ID:MM_KWN:55326
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney
Transcripts:ENSMUST00000034218,   NM_019415,   UC009MWC.1,   UC009MWD.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36896,852,471 - 96,853,257 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:108114 AgrOrtholog
Ensembl Genes ENSMUSG00000031766 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034218 ENTREZGENE
  ENSMUST00000034218.5 UniProtKB/Swiss-Prot
  ENSMUST00000211905.2 UniProtKB/TrEMBL
  ENSMUST00000212134.2 UniProtKB/TrEMBL
Gene3D-CATH Amino acid/polyamine transporter I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AA-permease/SLC12A_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AA_permease_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLC12_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLC12A3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLC12A_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20497 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:108114 ENTREZGENE
NCBI Gene 20497 ENTREZGENE
PANTHER PTHR11827 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11827:SF9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AA_permease UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AA_permease_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLC12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB SLC12A3 RGD
PhenoGen Slc12a3 PhenoGen
PRINTS NACLTRNSPORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1D5RLP7_MOUSE UniProtKB/TrEMBL
  A0A1D5RLX1_MOUSE UniProtKB/TrEMBL
  P59158 ENTREZGENE
  Q543E4 ENTREZGENE, UniProtKB/TrEMBL
  Q62439 ENTREZGENE, UniProtKB/TrEMBL
  S12A3_MOUSE UniProtKB/Swiss-Prot