Sox10 (SRY (sex determining region Y)-box 10) - Rat Genome Database

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Gene: Sox10 (SRY (sex determining region Y)-box 10) Mus musculus
Symbol: Sox10
Name: SRY (sex determining region Y)-box 10
RGD ID: 735897
Description: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; nervous system development; and neural crest cell migration. Acts upstream of or within several processes, including lacrimal gland development; melanocyte differentiation; and positive regulation of neuroblast proliferation. Located in mitochondrial outer membrane and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; inner ear; mesenchyme derived from neural crest; and nervous system. Used to study Kallmann syndrome; PCWH syndrome; and Waardenburg syndrome type 4C. Human ortholog(s) of this gene implicated in Kallmann syndrome; PCWH syndrome; Waardenburg syndrome type 2E; and Waardenburg syndrome type 4C. Orthologous to human SOX10 (SRY-box transcription factor 10).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Dom; dominant megacolon; gray tremor; gt; Sox; Sox21; SRY-box containing gene 10; transcription factor SOX-10; transcription factor SOX-M
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391579,039,113 - 79,048,690 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1579,039,108 - 79,049,440 (-)EnsemblGRCm39 Ensembl
GRCm381579,154,913 - 79,164,490 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1579,154,908 - 79,165,240 (-)EnsemblGRCm38mm10GRCm38
MGSCv371578,985,343 - 78,994,920 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361578,982,168 - 78,992,495 (-)NCBIMGSCv36mm8
Celera1581,267,600 - 81,277,195 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.7NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromatin  (ISO)
cytoplasm  (IDA)
membrane  (IEA)
mitochondrial outer membrane  (IDA)
mitochondrion  (IEA)
nucleoplasm  (ISO,TAS)
nucleus  (IBA,IDA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal action potential  (IAGP)
abnormal adrenal medulla morphology  (IAGP)
abnormal axon fasciculation  (IAGP)
abnormal axon guidance  (IAGP)
abnormal axon morphology  (IAGP)
abnormal coat/hair pigmentation  (IAGP)
abnormal colon morphology  (IAGP)
abnormal cranial ganglia morphology  (IAGP)
abnormal digestive system physiology  (IAGP)
abnormal dorsal root ganglion morphology  (IAGP)
abnormal enteric ganglia morphology  (IAGP)
abnormal enteric nervous system morphology  (IAGP)
abnormal enteric neural crest cell migration  (IAGP)
abnormal enteric neural crest cell morphology  (IAGP)
abnormal enteric neuron morphology  (IAGP)
abnormal frontonasal mesenchyme morphology  (IAGP)
abnormal gait  (IAGP)
abnormal glial cell morphology  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal limb posture  (IAGP)
abnormal locomotor behavior  (IAGP)
abnormal melanoblast migration  (IAGP)
abnormal melanoblast morphology  (IAGP)
abnormal melanocyte differentiation  (IAGP)
abnormal myelination  (IAGP)
abnormal nervous system morphology  (IAGP)
abnormal neural crest cell migration  (IAGP)
abnormal neural crest cell physiology  (IAGP)
abnormal neural crest morphology  (IAGP)
abnormal neuron proliferation  (IAGP)
abnormal nodose ganglion morphology  (IAGP)
abnormal olfactory bulb morphology  (IAGP)
abnormal oligodendrocyte physiology  (IAGP)
abnormal parasympathetic ganglion morphology  (IAGP)
abnormal PNS glial cell morphology  (IAGP)
abnormal rectum morphology  (IAGP)
abnormal Schwann cell morphology  (IAGP)
abnormal Schwann cell physiology  (IAGP)
abnormal sciatic nerve morphology  (IAGP)
abnormal sensory neuron morphology  (IAGP)
abnormal skin pigmentation  (IAGP)
abnormal spinal nerve morphology  (IAGP)
abnormal superior cervical ganglion morphology  (IAGP)
abnormal sympathetic ganglion morphology  (IAGP)
abnormal sympathetic neuron morphology  (IAGP)
abnormal vagal neural crest cell migration  (IAGP)
abnormal ventral spinal root morphology  (IAGP)
absent coat pigmentation  (IAGP)
absent enteric neural crest cell  (IAGP)
absent hair follicle melanin granules  (IAGP)
absent Schwann cells  (IAGP)
absent skin pigmentation  (IAGP)
aganglionic megacolon  (IAGP)
belly spot  (IAGP)
belted  (IAGP)
brain vacuoles  (IAGP)
cyanosis  (IAGP)
darkened coat color  (IAGP)
decreased birth body size  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased cell migration  (IAGP)
decreased foot pigmentation  (IAGP)
decreased melanocyte number  (IAGP)
decreased nerve conduction velocity  (IAGP)
decreased neuron number  (IAGP)
decreased oligodendrocyte number  (IAGP)
decreased Schwann cell number  (IAGP)
decreased tail pigmentation  (IEA)
demyelination  (IAGP)
dilated cochlea  (IAGP)
diluted coat color  (IAGP)
dorsal root ganglion degeneration  (IAGP)
dorsal root ganglion hypoplasia  (IAGP)
dysmyelination  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
gliosis  (IAGP)
head blaze  (IAGP)
head spot  (IAGP)
hyperresponsive to tactile stimuli  (IAGP)
hypopigmentation  (IAGP)
impaired coordination  (IAGP)
increased neuron apoptosis  (IAGP)
increased vagal neural crest cell apoptosis  (IAGP)
kinked tail  (IAGP)
lethality at weaning, incomplete penetrance  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
megacolon  (IAGP)
motor neuron degeneration  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
non-pigmented tail tip  (IAGP)
open neural tube  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
respiratory failure  (IAGP)
seizures  (IAGP)
small dorsal root ganglion  (IAGP)
spongiform encephalopathy  (IAGP)
sporadic seizures  (IAGP)
tremors  (IAGP)
unresponsive to tactile stimuli  (IAGP)
variable body spotting  (IAGP)
white spotting  (IAGP)

References - curated
# Reference Title Reference Citation
1. Genetic counseling for a three-generation Chinese family with Waardenburg syndrome type II associated with a rare SOX10 mutation. Chen K, etal., Int J Pediatr Otorhinolaryngol. 2015 May;79(5):745-8. doi: 10.1016/j.ijporl.2015.03.006. Epub 2015 Mar 17.
2. Mutation of the Sry-related Sox10 gene in Dominant megacolon, a mouse model for human Hirschsprung disease. Herbarth B, etal., Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5161-5.
3. Additive dominant effect of a SOX10 mutation underlies a complex phenotype of PCWH. Ito Y, etal., Neurobiol Dis. 2015 Aug;80:1-14. doi: 10.1016/j.nbd.2015.04.013. Epub 2015 May 7.
4. Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. Lu QR, etal., Cell 2002 Apr 5;109(1):75-86.
5. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
6. MGDs mouse GO annotations MGD data from the GO Consortium
8. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. Loss-of-function mutations in SOX10 cause Kallmann syndrome with deafness. Pingault V, etal., Am J Hum Genet. 2013 May 2;92(5):707-24. doi: 10.1016/j.ajhg.2013.03.024.
11. SOX10 mutations in patients with Waardenburg-Hirschsprung disease. Pingault V, etal., Nat Genet. 1998 Feb;18(2):171-3.
12. Mouse MP Annotation Import Pipeline RGD automated import pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Functional analysis of Waardenburg syndrome-associated PAX3 and SOX10 mutations: report of a dominant-negative SOX10 mutation in Waardenburg syndrome type II. Zhang H, etal., Hum Genet. 2012 Mar;131(3):491-503. doi: 10.1007/s00439-011-1098-2. Epub 2011 Oct 1.
Additional References at PubMed
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PMID:33155500   PMID:33192541   PMID:33277484   PMID:33316258   PMID:33322598   PMID:33340715   PMID:33462220   PMID:33500353   PMID:33510480   PMID:33601405   PMID:33775695   PMID:33833454  
PMID:33935652   PMID:33958373   PMID:33985544   PMID:34061953   PMID:34093128   PMID:34133940   PMID:34184034   PMID:34193412   PMID:34234180   PMID:34272903   PMID:34274976   PMID:34336815  
PMID:34383890   PMID:34425092   PMID:34429415   PMID:34519339   PMID:34557485   PMID:34615523   PMID:34630045   PMID:34644112   PMID:34879275   PMID:34963132   PMID:34988124   PMID:35019839  
PMID:35022234   PMID:35084365   PMID:35127681   PMID:35173232   PMID:35252209   PMID:35399523   PMID:35420781   PMID:35568059   PMID:35614045   PMID:35695185   PMID:35713404   PMID:35781329  
PMID:35815410   PMID:35839257   PMID:35878429   PMID:35899771   PMID:35925886   PMID:36012294   PMID:36074819   PMID:36210210   PMID:36305367   PMID:36318265   PMID:36343245   PMID:36657722  
PMID:36724256   PMID:36779913   PMID:36867129   PMID:36897571   PMID:36919939   PMID:36941249   PMID:36941270   PMID:37102702   PMID:37279265   PMID:37371026   PMID:37481722   PMID:37573008  
PMID:37589570   PMID:37591247   PMID:37684687   PMID:37737269   PMID:37821496   PMID:37838739   PMID:37885410   PMID:37897724   PMID:38025786   PMID:38078651   PMID:38102338   PMID:38103869  
PMID:38159590   PMID:38167468   PMID:38338705  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391579,039,113 - 79,048,690 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1579,039,108 - 79,049,440 (-)EnsemblGRCm39 Ensembl
GRCm381579,154,913 - 79,164,490 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1579,154,908 - 79,165,240 (-)EnsemblGRCm38mm10GRCm38
MGSCv371578,985,343 - 78,994,920 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361578,982,168 - 78,992,495 (-)NCBIMGSCv36mm8
Celera1581,267,600 - 81,277,195 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.7NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382237,972,312 - 37,984,555 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2237,970,686 - 37,987,422 (-)EnsemblGRCh38hg38GRCh38
GRCh372238,368,319 - 38,380,562 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362236,698,265 - 36,710,485 (-)NCBINCBI36Build 36hg18NCBI36
Build 342236,692,819 - 36,705,039NCBI
Celera2222,170,048 - 22,182,268 (-)NCBICelera
Cytogenetic Map22q13.1NCBI
HuRef2221,334,376 - 21,346,534 (-)NCBIHuRef
CHM1_12238,327,060 - 38,339,280 (-)NCBICHM1_1
T2T-CHM13v2.02238,433,934 - 38,446,177 (-)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr87112,605,721 - 112,615,097 (-)NCBIGRCr8
mRatBN7.27110,725,274 - 110,734,651 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7110,725,274 - 110,735,544 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7112,473,920 - 112,483,178 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07114,697,448 - 114,706,706 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07114,666,769 - 114,676,030 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07120,393,238 - 120,403,523 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7120,393,254 - 120,403,523 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07120,387,071 - 120,397,340 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47117,138,694 - 117,149,939 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17117,172,923 - 117,184,169 (-)NCBI
Celera7107,059,767 - 107,070,023 (-)NCBICelera
RH 3.4 Map7839.3RGD
Cytogenetic Map7q34NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541324,311,783 - 24,323,315 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541324,313,311 - 24,323,112 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v22347,828,983 - 47,841,204 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12250,517,348 - 50,529,603 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02218,885,679 - 18,897,927 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12236,712,128 - 36,724,192 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2236,713,310 - 36,723,439 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11026,680,441 - 26,690,530 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1026,681,122 - 26,689,882 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1026,635,515 - 26,646,171 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01027,472,272 - 27,482,931 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1027,472,118 - 27,482,924 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11027,192,256 - 27,202,906 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01027,503,817 - 27,514,467 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01027,681,016 - 27,691,677 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494510,163,344 - 10,174,369 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364923,173,741 - 3,185,024 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364923,173,770 - 3,183,423 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl59,891,525 - 9,901,743 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.159,890,439 - 9,901,746 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.257,289,992 - 7,299,054 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11920,673,053 - 20,685,506 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045105,090,681 - 105,103,173 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247529,965,756 - 9,973,777 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247529,965,015 - 9,976,244 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Sox10
297 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:614
Count of miRNA genes:351
Interacting mature miRNAs:411
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226734Tibmd5_mtibia midshaft diameter 5, 10 week (mouse)15612948186684201Mouse
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156129481100797881Mouse
27226777Tibl8_mtibia length 8, 5 week (mouse)15692948184584201Mouse
1301433Rapop5_mradiation-induced apoptosis 5 (mouse)Not determined15927302279474762Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402203102896555Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800146102008435Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578416103425899Mouse
27226729Tibmd2_mtibia midshaft diameter 2, 5 week (mouse)153800024486684201Mouse
26884402Cvht9_mcranial vault height 9, 16 week (mouse)154216339695497881Mouse
1357756Alaa4_malopecia areata 4 (mouse)Not determined154638964680389845Mouse
10755515Amzn3_manatomical modifier of Zfp423 3 (mouse)154638964680389845Mouse
1301006Hfib1_mhepatic fibrogenesis 1 (mouse)Not determined154730633481306479Mouse
1301860Gct3_mgranulosa cell tumorigenesis 3 (mouse)Not determined154740959681409691Mouse
26884397Humsd5_mhumerus midshaft diameter 5, 10 week (mouse)154836339698397881Mouse
26884399Humsd1_mhumerus midshaft diameter 1, 5 week (mouse)1548363396101708435Mouse
1301429Pcir3_mperiosteal circumference 3 (mouse)Not determined154846536282465496Mouse
4142198Hbtq_mhabituation QTL (mouse)Not determined155116070885160833Mouse
10045637Heal27_mwound healing/regeneration 29 (mouse)Not determined155141836185418511Mouse
10412067Pain2_mpain 2 (mouse)Not determined155164533985645626Mouse
1302080Szs13_mseizure susceptibility 13 (mouse)Not determined155168583285694449Mouse
1301708Cocrb14_mcocaine related behavior 14 (mouse)Not determined155180651585806651Mouse
38501067Tip3_mtuberculosis immunophenotype 3, IFN-g level (mouse)155356339689584203Mouse
13504731Cath5_mcarotid atherosclerosis 5 (mouse)155478912988789129Mouse
1302074Bmd4_mbone mineral density 4 (mouse)Not determined1556186708103425899Mouse
27095936Ulnl4_mulna length 4, 5 week (mouse)155676339687684201Mouse
1300800Ses3_msalmonella enteritidis susceptibility 3 (mouse)Not determined155711700591117153Mouse
1357407Pfat4_mpredicted fat percentage 4 (mouse)8.6Body fat amountpredicted fat percentage155711700591117153Mouse
12880420V25Dq8_mvitamin D inactive form serum level QTL 8 (mouse)156158420095584200Mouse
1301601Faq9_mfluctuating asymmetry QTL 9 (mouse)Not determined156316390397163995Mouse
1558786Msq1_mMAV-1 susceptibility QTL 1 (mouse)Not determined156338964681086436Mouse
1302197Bhr2_mbronchial hyperresponsiveness 2 (mouse)Not determined1564306334103425899Mouse
4141135Cia35_mcollagen induced arthritis 35 (mouse)Not determined156481182698811946Mouse
1301119Drb7_mdopamine receptor binding 7 (mouse)Not determined156533657899341028Mouse
1301171Brm2_mbrachyury modifier 2 (mouse)Not determined156552537699525499Mouse
4141921Pstc3_mperiosteal circumference 3 (mouse)Not determined1567270698101270847Mouse
1300627Sluc26_msusceptibility to lung cancer 26 (mouse)Not determined1570345653104073951Mouse
1300648Dbsty4_mdiabesity 4 (mouse)Not determined1570349271104073951Mouse
1300726Pitm4_mprion incubation time 4 (mouse)Not determined1570349271104073951Mouse
1302002Cocia2_mcocaine induced activation 2 (mouse)Not determined157237245979899178Mouse
14747011Mancz13_mmandible centroid size 13 (mouse)1572382669104073951Mouse
12791003Aath8_maortic arch atherosclerosis 8 (mouse)1573430144104073951Mouse
15092079Igly6_mIgG glycosylation 6, GP6 (mouse)157410054082674156Mouse
13442492Mecth2_mmechanosensation threshold 2 (mouse)157466284979387201Mouse
1301472Pain1_mpain 1 (mouse)Not determined157532084690813185Mouse
1300851Heal4_mwound healing/regeneration 4 (mouse)Not determined1577527592104073951Mouse
15092080Igly7_mIgG glycosylation 7, GP10 (mouse)157779491982674156Mouse
4142060W3q6_mweight 3 weeks QTL 6 (mouse)Not determined78601103102901704Mouse
1357894Epfpq3_mepididymal fat percentage QTL 3 (mouse)Not determined1578601103102901704Mouse
14928306Manh79_mmandible shape 79 (mouse)1578847557104073951Mouse
12880411V125Dq11_mvitamin D active form serum level QTL 11 (mouse)1578897881104073951Mouse

Markers in Region
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381579,154,954 - 79,155,147UniSTSGRCm38
MGSCv371578,985,384 - 78,985,577UniSTSGRCm37
Celera1581,267,641 - 81,267,834UniSTS
Cytogenetic Map15E1UniSTS
cM Map1546.6UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381579,155,249 - 79,155,512UniSTSGRCm38
MGSCv371578,985,679 - 78,985,942UniSTSGRCm37
Celera1581,267,937 - 81,268,226UniSTS
Cytogenetic Map15E1UniSTS
cM Map1546.6UniSTS



Nucleotide Sequences
RefSeq Transcripts NM_011437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF017182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF047043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF047389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK042542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK043220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL591921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC051058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D87031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U66141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U70441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z18959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000040019   ⟹   ENSMUSP00000039466
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1579,039,113 - 79,048,690 (-)Ensembl
GRCm38.p6 Ensembl1579,154,913 - 79,164,490 (-)Ensembl
RefSeq Acc Id: ENSMUST00000230261   ⟹   ENSMUSP00000155639
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1579,040,441 - 79,048,674 (-)Ensembl
GRCm38.p6 Ensembl1579,156,241 - 79,164,474 (-)Ensembl
RefSeq Acc Id: ENSMUST00000230532   ⟹   ENSMUSP00000155574
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1579,039,108 - 79,049,440 (-)Ensembl
GRCm38.p6 Ensembl1579,154,908 - 79,165,240 (-)Ensembl
RefSeq Acc Id: ENSMUST00000230891
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1579,047,218 - 79,048,686 (-)Ensembl
GRCm38.p6 Ensembl1579,163,018 - 79,164,486 (-)Ensembl
RefSeq Acc Id: NM_011437   ⟹   NP_035567
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391579,039,113 - 79,048,690 (-)NCBI
GRCm381579,154,913 - 79,164,490 (-)NCBI
MGSCv371578,985,343 - 78,994,920 (-)RGD
Celera1581,267,600 - 81,277,195 (-)RGD
RefSeq Acc Id: NP_035567   ⟸   NM_011437
- UniProtKB: O54856 (UniProtKB/Swiss-Prot),   O09141 (UniProtKB/Swiss-Prot),   O08518 (UniProtKB/Swiss-Prot),   P70416 (UniProtKB/Swiss-Prot),   Q04888 (UniProtKB/Swiss-Prot),   Q8C916 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000039466   ⟸   ENSMUST00000040019
RefSeq Acc Id: ENSMUSP00000155574   ⟸   ENSMUST00000230532
RefSeq Acc Id: ENSMUSP00000155639   ⟸   ENSMUST00000230261
Protein Domains
HMG box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q04888-F1-model_v2 AlphaFold Q04888 1-466 view protein structure

RGD ID:6826503
Promoter ID:MM_KWN:19045
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day2,   Brain,   MEF_B6
Mouse AssemblyChrPosition (strand)Source
MGSCv361578,985,401 - 78,986,802 (-)MPROMDB
RGD ID:8684322
Promoter ID:EPDNEW_M20192
Type:multiple initiation site
Description:Mus musculus SRY -box 10 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm381579,164,486 - 79,164,546EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98358 AgrOrtholog
Ensembl Genes ENSMUSG00000033006 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000040019 ENTREZGENE
  ENSMUST00000040019.5 UniProtKB/Swiss-Prot
  ENSMUST00000230261.2 UniProtKB/TrEMBL
  ENSMUST00000230532.2 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro HMG_box_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_box_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sox_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20665 UniProtKB/Swiss-Prot
PANTHER SOX100B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HMG_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sox_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sox10 PhenoGen
PROSITE HMG_BOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HMG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47095 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  O88418_MOUSE UniProtKB/TrEMBL
  SOX10_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary O08518 UniProtKB/Swiss-Prot
  O09141 UniProtKB/Swiss-Prot
  O54856 UniProtKB/Swiss-Prot
  P70416 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-26 Sox10  SRY (sex determining region Y)-box 10    SRY-box containing gene 10  Symbol and/or name change 5135510 APPROVED