Hr (lysine demethylase and nuclear receptor corepressor) - Rat Genome Database

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Gene: Hr (lysine demethylase and nuclear receptor corepressor) Mus musculus
Analyze
Symbol: Hr
Name: lysine demethylase and nuclear receptor corepressor
RGD ID: 735796
MGI Page MGI
Description: Enables transcription corepressor activity. Acts upstream of or within negative regulation of DNA-templated transcription. Located in nuclear body. Is expressed in several structures, including alimentary system; brain; hair follicle; lower urinary tract; and sensory organ. Used to study alopecia universalis; atrichia with papular lesions; and hypotrichosis 4. Human ortholog(s) of this gene implicated in alopecia; alopecia universalis; and atrichia with papular lesions. Orthologous to human HR (HR lysine demethylase and nuclear receptor corepressor).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: [histone H3]-dimethyl-L-lysine(9) demethylase hairless; ALUNC; AU; b; ba; bld; bldy; hairless; lysine-specific demethylase hairless; N; r; rh; rh-bm; rh-bmh; rhino
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391470,789,644 - 70,810,988 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1470,789,652 - 70,810,988 (+)EnsemblGRCm39 Ensembl
GRCm381470,554,056 - 70,573,548 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1470,552,212 - 70,573,548 (+)EnsemblGRCm38mm10GRCm38
MGSCv371470,953,863 - 70,973,350 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361469,289,136 - 69,308,623 (+)NCBIMGSCv36mm8
Celera1468,095,776 - 68,115,052 (+)NCBICelera
Cytogenetic Map14D2NCBI
cM Map1436.32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
Butylparaben  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
choline  (EXP)
chrysene  (EXP)
cisplatin  (ISO)
clobetasol  (EXP)
copper(II) chloride  (ISO)
Cuprizon  (ISO)
DDE  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
enzacamene  (ISO)
flavonoids  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
genistein  (ISO)
gentamycin  (ISO)
L-methionine  (EXP)
lead(0)  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
Mesaconitine  (ISO)
methamphetamine  (ISO)
methimazole  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-ethyl-N-nitrosourea  (EXP)
niclosamide  (ISO)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (EXP,ISO)
pirinixic acid  (EXP)
potassium dichromate  (EXP)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenite  (ISO)
staurosporine  (EXP,ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
testosterone  (EXP)
thapsigargin  (EXP)
thyroxine  (ISO)
trichostatin A  (ISO)
trimethyltin  (EXP)
triptonide  (EXP)
tunicamycin  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal coat appearance  (IAGP)
abnormal coat/ hair morphology  (IEA)
abnormal colon morphology  (IAGP)
abnormal cornea morphology  (IAGP)
abnormal dermal layer morphology  (IAGP)
abnormal dermis reticular layer morphology  (IEA)
abnormal epidermal layer morphology  (IAGP)
abnormal epidermis stratum corneum morphology  (IAGP)
abnormal epidermis stratum granulosum morphology  (IAGP)
abnormal eyelid margin morphology  (IAGP)
abnormal eyelid morphology  (IAGP)
abnormal forehead morphology  (IEA)
abnormal hair cycle  (IAGP)
abnormal hair follicle dermal papilla morphology  (IAGP)
abnormal hair follicle infundibulum morphology  (IAGP)
abnormal hair follicle inner root sheath morphology  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal hair follicle outer root sheath morphology  (IAGP)
abnormal hair growth  (IAGP)
abnormal hair shaft morphology  (IAGP)
abnormal heart looping  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal immunoglobulin level  (IAGP)
abnormal intestinal mucosa morphology  (IAGP)
abnormal keratinocyte differentiation  (IAGP)
abnormal lactation  (IAGP)
abnormal lymph node secondary follicle morphology  (IAGP)
abnormal mammary gland morphology  (IEA)
abnormal Meibomian gland acinus morphology  (IAGP)
abnormal Meibomian gland morphology  (IAGP)
abnormal melanocyte morphology  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal nipple development  (IEA)
abnormal nursing  (IAGP)
abnormal physiological neovascularization  (IAGP)
abnormal piliary canal morphology  (IEA)
abnormal sebaceous gland morphology  (IAGP)
abnormal skin adnexa physiology  (IEA)
abnormal skin appearance  (IAGP)
abnormal skin condition  (IAGP)
abnormal skin morphology  (IAGP)
abnormal skin physiology  (IAGP)
abnormal skin pigmentation  (IAGP)
abnormal somite border morphology  (IAGP)
abnormal thymus involution  (IAGP)
abnormal tumor morphology  (IAGP)
abnormal vibrissa follicle morphology  (IAGP)
abnormal vibrissa morphology  (IAGP)
abnormal vibrissa number  (IAGP)
absent cochlear hair cell stereocilia  (IAGP)
absent hair follicle dermal papilla  (IAGP)
absent linear vestibular evoked potential  (IAGP)
absent mammary gland  (IEA)
absent vibrissae  (IEA)
acanthosis  (IAGP)
alopecia  (IAGP)
blepharitis  (IAGP)
caudal body truncation  (IAGP)
cochlear ganglion hypoplasia  (IAGP)
curly vibrissae  (IAGP)
decreased birth body size  (IAGP)
decreased body size  (IEA)
decreased body weight  (IEA)
decreased cell proliferation  (IAGP)
decreased circulating alkaline phosphatase level  (IEA)
decreased circulating amylase level  (IEA)
decreased circulating cholesterol level  (IEA)
decreased circulating HDL cholesterol level  (IEA)
decreased cochlear inner hair cell number  (IAGP)
decreased cochlear outer hair cell number  (IAGP)
decreased embryo size  (IAGP)
decreased IgM level  (IAGP)
decreased incidence of tumors by UV induction  (IAGP)
decreased lymphocyte cell number  (IEA)
decreased nipple number  (IEA)
decreased ovulation rate  (IAGP)
decreased prostaglandin level  (IAGP)
decreased sebocyte cell number  (IAGP)
decreased sensitivity to skin irradiation  (IAGP)
decreased small intestinal villus height  (IAGP)
decreased T cell number  (IAGP)
decreased T cell proliferation  (IAGP)
decreased thymus weight  (IAGP)
decreased white adipose tissue amount  (IAGP)
deformed nails  (IAGP)
dermal cyst  (IAGP)
dilated hair follicle  (IAGP)
dilated hair follicle infundibulum  (IAGP)
dilated piliary canal  (IAGP)
edema  (IAGP)
enlarged inguinal lymph nodes  (IAGP)
enlarged pericardium  (IAGP)
enlarged popliteal lymph nodes  (IAGP)
epidermal cyst  (IAGP)
epidermal hyperplasia  (IAGP)
epidermis stratum granulosum hyperplasia  (IAGP)
eye inflammation  (IAGP)
female infertility  (IAGP)
flaky skin  (IAGP)
glomerulonephritis  (IAGP)
granulomatous inflammation  (IAGP)
hair follicle degeneration  (IAGP)
hairless  (IAGP)
hypergranulosis  (IAGP)
hyperkeratosis  (IAGP)
increased body weight  (IAGP)
increased cell proliferation  (IAGP)
increased IgG level  (IAGP)
increased incidence of tumors by UV-induction  (IAGP)
increased leukemia incidence  (IAGP)
increased lymphoma incidence  (IAGP)
increased macrophage cell number  (IAGP)
increased melanocyte number  (IAGP)
increased mortality induced by ionizing radiation  (IAGP)
increased neutrophil cell number  (IEA)
increased prostaglandin level  (IAGP)
increased sensitivity to skin irradiation  (IAGP)
increased skin papilloma incidence  (IAGP)
increased skin squamous cell carcinoma incidence  (IAGP)
increased skin tumor incidence  (IAGP)
increased squamous cell carcinoma incidence  (IAGP)
increased susceptibility to autoimmune disorder  (IAGP)
increased tumor growth/size  (IAGP)
long toenails  (IAGP)
loose skin  (IAGP)
loss of eyelid cilia  (IAGP)
loss of vibrissae  (IAGP)
lymph node inflammation  (IAGP)
lymph node medullary cord hyperplasia  (IAGP)
Meibomian gland atrophy  (IAGP)
Meibomian gland cyst  (IAGP)
Meibomian gland inflammation  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, complete penetrance  (IAGP)
preweaning lethality, incomplete penetrance  (IEA)
progressive hair loss  (IAGP)
sebaceous gland atrophy  (IEA)
shiny skin  (IAGP)
short hair  (IAGP)
short vibrissae  (IAGP)
skin hyperplasia  (IAGP)
skin lesions  (IAGP)
skin ridges  (IEA)
small pharyngeal arch  (IAGP)
small sebaceous gland  (IAGP)
sparse hair  (IAGP)
telencephalon hypoplasia  (IAGP)
thick dermal layer  (IAGP)
thick epidermis  (IAGP)
thick eyelids  (IAGP)
thick skin  (IAGP)
thin hypodermis  (IAGP)
thin retina ganglion layer  (IAGP)
thin retina inner plexiform layer  (IAGP)
thin skin  (IAGP)
thymus atrophy  (IAGP)
thymus cortex atrophy  (IAGP)
translucent skin  (IEA)
uveitis  (IAGP)
wavy vibrissae  (IAGP)
wrinkled skin  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Cloning, genomic organization, alternative transcripts and mutational analysis of the gene responsible for autosomal recessive universal congenital alopecia. Cichon S, etal., Hum Mol Genet. 1998 Oct;7(11):1671-9.
2. Kyoto rhino rats derived by ENU mutagenesis undergo congenital hair loss and exhibit focal glomerulosclerosis. Kuramoto T, etal., Exp Anim. 2011;60(1):57-63. doi: 10.1538/expanim.60.57.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Congenital atrichia in five Arab Palestinian families resulting from a deletion mutation in the human hairless gene. Zlotogorski A, etal., Hum Genet. 1998 Oct;103(4):400-4.
Additional References at PubMed
PMID:92985   PMID:186616   PMID:201855   PMID:213736   PMID:310859   PMID:1346779   PMID:1362829   PMID:1371498   PMID:1483932   PMID:1535334   PMID:1537334   PMID:1545145  
PMID:1611214   PMID:1717701   PMID:1794058   PMID:1962578   PMID:1970330   PMID:1971251   PMID:2196000   PMID:2276985   PMID:2458328   PMID:2570031   PMID:2828679   PMID:2840205  
PMID:3297105   PMID:3971387   PMID:4147629   PMID:4310515   PMID:4588546   PMID:4869134   PMID:5055128   PMID:5118596   PMID:5774889   PMID:5971566   PMID:6265551   PMID:6447727  
PMID:6470519   PMID:6863894   PMID:6968145   PMID:6968290   PMID:6971254   PMID:7513463   PMID:7519779   PMID:7625860   PMID:7640630   PMID:7662562   PMID:7717866   PMID:7738376  
PMID:7767977   PMID:7768961   PMID:7974484   PMID:7982204   PMID:8016216   PMID:8027588   PMID:8052649   PMID:8071640   PMID:8103276   PMID:8103799   PMID:8176260   PMID:8253147  
PMID:8281013   PMID:8453636   PMID:8703131   PMID:8757756   PMID:8919041   PMID:8987811   PMID:9129223   PMID:9284107   PMID:9322939   PMID:9328433   PMID:9445480   PMID:9498108  
PMID:9600352   PMID:9620297   PMID:9684974   PMID:9697832   PMID:9799606   PMID:9832205   PMID:9832313   PMID:9832316   PMID:9832318   PMID:10051399   PMID:10349636   PMID:10393848  
PMID:10493513   PMID:10500206   PMID:10536052   PMID:10544884   PMID:10606630   PMID:10674375   PMID:10994776   PMID:11009445   PMID:11013214   PMID:11042159   PMID:11076861   PMID:11179494  
PMID:11217851   PMID:11327202   PMID:11371349   PMID:11591709   PMID:11641275   PMID:11687974   PMID:11926302   PMID:12403844   PMID:12466851   PMID:12477932   PMID:12531021   PMID:12844483  
PMID:12873232   PMID:12949841   PMID:13367821   PMID:14471512   PMID:14517347   PMID:14889254   PMID:14946445   PMID:15010296   PMID:15126630   PMID:15191552   PMID:15280217   PMID:15489334  
PMID:15498793   PMID:15606500   PMID:15618518   PMID:15654980   PMID:15665986   PMID:15870393   PMID:15955095   PMID:16141072   PMID:16141073   PMID:16195376   PMID:16235133   PMID:16378938  
PMID:16410833   PMID:16455232   PMID:16461637   PMID:16571082   PMID:16587618   PMID:16679309   PMID:16679559   PMID:16682947   PMID:16691196   PMID:16699173   PMID:16778787   PMID:16917495  
PMID:16920988   PMID:16977324   PMID:17003502   PMID:17159911   PMID:17177600   PMID:17219415   PMID:17246610   PMID:17330134   PMID:17485446   PMID:17657241   PMID:17717424   PMID:17943185  
PMID:17951050   PMID:18287559   PMID:18305573   PMID:18463679   PMID:18535184   PMID:18688025   PMID:19005485   PMID:19122663   PMID:19513791   PMID:19626035   PMID:19776181   PMID:19897589  
PMID:20008033   PMID:20080498   PMID:20087431   PMID:20211142   PMID:20304950   PMID:20448060   PMID:20458748   PMID:20587514   PMID:20675829   PMID:20886113   PMID:20944649   PMID:21020475  
PMID:21083932   PMID:21525235   PMID:21677750   PMID:21777520   PMID:21796152   PMID:21873635   PMID:21894148   PMID:22161643   PMID:22308360   PMID:22417302   PMID:22442153   PMID:22467332  
PMID:22751115   PMID:22761871   PMID:22834956   PMID:22964757   PMID:23096703   PMID:23523584   PMID:23545178   PMID:23696569   PMID:23702391   PMID:23702581   PMID:23800061   PMID:23903062  
PMID:23954555   PMID:23966300   PMID:24079733   PMID:24129062   PMID:24141030   PMID:24144727   PMID:24631180   PMID:24732399   PMID:24732442   PMID:24845637   PMID:24952961   PMID:25062774  
PMID:25094045   PMID:25127551   PMID:25791923   PMID:26015562   PMID:26992132   PMID:26998821   PMID:27095432   PMID:27528504   PMID:27880932   PMID:28407057   PMID:28679963   PMID:28717054  
PMID:28765044   PMID:29182680   PMID:29377107   PMID:29422543   PMID:29908149   PMID:30013037   PMID:30389142   PMID:30865688   PMID:31382467   PMID:31669249   PMID:31826981   PMID:34162906  
PMID:34248495   PMID:34368113   PMID:34493660   PMID:36166296   PMID:36934646   PMID:37679611   PMID:38355793   PMID:38655702  


Genomics

Comparative Map Data
Hr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391470,789,644 - 70,810,988 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1470,789,652 - 70,810,988 (+)EnsemblGRCm39 Ensembl
GRCm381470,554,056 - 70,573,548 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1470,552,212 - 70,573,548 (+)EnsemblGRCm38mm10GRCm38
MGSCv371470,953,863 - 70,973,350 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361469,289,136 - 69,308,623 (+)NCBIMGSCv36mm8
Celera1468,095,776 - 68,115,052 (+)NCBICelera
Cytogenetic Map14D2NCBI
cM Map1436.32NCBI
HR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38822,114,419 - 22,131,052 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl822,114,419 - 22,133,384 (-)EnsemblGRCh38hg38GRCh38
GRCh37821,971,932 - 21,988,565 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36822,027,877 - 22,043,975 (-)NCBINCBI36Build 36hg18NCBI36
Build 34822,028,526 - 22,045,326NCBI
Celera820,934,236 - 20,950,880 (-)NCBICelera
Cytogenetic Map8p21.3NCBI
HuRef820,514,477 - 20,541,503 (-)NCBIHuRef
CHM1_1822,173,616 - 22,190,245 (-)NCBICHM1_1
T2T-CHM13v2.0822,388,371 - 22,405,000 (-)NCBIT2T-CHM13v2.0
Hr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81552,036,540 - 52,056,019 (+)NCBIGRCr8
mRatBN7.21545,626,835 - 45,646,313 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1545,626,835 - 45,646,313 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1549,744,700 - 49,764,175 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01550,856,205 - 50,875,680 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01547,715,507 - 47,734,986 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01552,241,801 - 52,261,276 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1552,241,801 - 52,261,276 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01555,967,613 - 55,984,797 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41550,957,053 - 50,972,842 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11550,972,821 - 50,988,623 (+)NCBI
Celera1545,305,217 - 45,324,692 (+)NCBICelera
Cytogenetic Map15p11NCBI
Hr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540345,605,510 - 45,624,402 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540345,605,870 - 45,624,386 (-)NCBIChiLan1.0ChiLan1.0
HR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2740,616,243 - 40,630,986 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1816,341,438 - 16,357,572 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0821,359,348 - 21,378,315 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1818,298,709 - 18,316,151 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl818,298,709 - 18,316,151 (-)Ensemblpanpan1.1panPan2
HR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12535,120,566 - 35,136,560 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2535,119,784 - 35,135,545 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2535,710,085 - 35,727,556 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02535,332,063 - 35,349,535 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2535,333,417 - 35,347,559 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12535,277,299 - 35,294,762 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02535,131,873 - 35,149,314 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02535,287,349 - 35,304,802 (+)NCBIUU_Cfam_GSD_1.0
Hr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494312,612,526 - 12,634,082 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365555,936,220 - 5,954,974 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365555,936,431 - 5,954,852 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl146,386,903 - 6,407,031 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1146,386,900 - 6,404,968 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2146,822,598 - 6,840,654 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1820,183,797 - 20,207,510 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl820,183,677 - 20,198,700 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605222,028,581 - 22,052,527 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475817,699,400 - 17,715,482 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475817,699,357 - 17,719,188 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hr
748 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1998
Count of miRNA genes:504
Interacting mature miRNAs:614
Transcripts:ENSMUST00000022691, ENSMUST00000159959, ENSMUST00000161069, ENSMUST00000161468, ENSMUST00000163060
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144945542583455556Mouse
4142364Pbwg18_mpostnatal body weight growth 18 (mouse)Not determined145228198486282125Mouse
1301489Lbm10_mlean body mass 10 (mouse)Not determined145376129687761529Mouse
12880432Fgf23lq3_mFGF23 serum level QTL 3 (mouse)145393744087937440Mouse
10043889Cia52_mcollagen induced arthritis QTL 52 (mouse)Not determined145608238190082509Mouse
1301562Hwq1_mheart weight quantitative locus 1 (mouse)Not determined145654674590546941Mouse
1357565wrmod1_mwobbler modifier 1 (mouse)Not determined1458179640101859473Mouse
11039527Ccc2_mcolitis susceptibility in the Collaborative Cross 2 (mouse)145991861294138217Mouse
1300666Fembm2_mfemoral bone morphometry 2 (mouse)Not determined146239746096397680Mouse
14747006Mancz12_mmandible centroid size 12 (mouse)1470071977104071977Mouse

Markers in Region
hr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381470,562,802 - 70,562,964UniSTSGRCm38
MGSCv371470,962,609 - 70,962,771UniSTSGRCm37
Celera1468,104,520 - 68,104,667UniSTS
Cytogenetic Map14D2UniSTS
cM Map1439.5UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001379479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001424473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001424474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_021877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036158473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB221596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB221597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC122268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK076280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY312855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY547390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY547391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC048552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC049182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z32675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000022691   ⟹   ENSMUSP00000022691
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1470,791,496 - 70,810,988 (+)Ensembl
GRCm38.p6 Ensembl1470,554,056 - 70,573,548 (+)Ensembl
RefSeq Acc Id: ENSMUST00000159959
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1470,789,652 - 70,792,159 (+)Ensembl
GRCm38.p6 Ensembl1470,552,212 - 70,554,719 (+)Ensembl
RefSeq Acc Id: ENSMUST00000161069   ⟹   ENSMUSP00000124816
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1470,791,127 - 70,810,340 (+)Ensembl
GRCm38.p6 Ensembl1470,553,687 - 70,572,900 (+)Ensembl
RefSeq Acc Id: ENSMUST00000161468
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1470,789,685 - 70,792,105 (+)Ensembl
GRCm38.p6 Ensembl1470,552,245 - 70,554,665 (+)Ensembl
RefSeq Acc Id: ENSMUST00000163060   ⟹   ENSMUSP00000124042
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1470,793,340 - 70,810,984 (+)Ensembl
GRCm38.p6 Ensembl1470,555,900 - 70,573,544 (+)Ensembl
RefSeq Acc Id: NM_001379479   ⟹   NP_001366408
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391470,791,674 - 70,810,988 (+)NCBI
GRCm381470,554,234 - 70,573,548 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001424473   ⟹   NP_001411402
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391470,789,644 - 70,810,988 (+)NCBI
RefSeq Acc Id: NM_001424474   ⟹   NP_001411403
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391470,789,644 - 70,810,988 (+)NCBI
RefSeq Acc Id: NM_021877   ⟹   NP_068677
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391470,791,496 - 70,810,988 (+)NCBI
GRCm381470,554,056 - 70,573,548 (+)NCBI
MGSCv371470,953,863 - 70,973,350 (+)RGD
Celera1468,095,776 - 68,115,057 (+)NCBI
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036158473   ⟹   XP_036014366
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391470,791,190 - 70,810,988 (+)NCBI
Sequence:
RefSeq Acc Id: NP_068677   ⟸   NM_021877
- UniProtKB: Q80Y47 (UniProtKB/Swiss-Prot),   Q61645 (UniProtKB/Swiss-Prot),   Q4QY90 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001366408   ⟸   NM_001379479
- UniProtKB: Q61645 (UniProtKB/Swiss-Prot),   Q80Y47 (UniProtKB/Swiss-Prot),   Q4QY90 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000124042   ⟸   ENSMUST00000163060
RefSeq Acc Id: ENSMUSP00000022691   ⟸   ENSMUST00000022691
RefSeq Acc Id: ENSMUSP00000124816   ⟸   ENSMUST00000161069
RefSeq Acc Id: XP_036014366   ⟸   XM_036158473
- Peptide Label: isoform X1
- UniProtKB: Q61645 (UniProtKB/Swiss-Prot),   Q80Y47 (UniProtKB/Swiss-Prot),   Q4QY90 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001411403   ⟸   NM_001424474
- UniProtKB: Q80Y47 (UniProtKB/Swiss-Prot),   Q61645 (UniProtKB/Swiss-Prot),   Q4QY90 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001411402   ⟸   NM_001424473
- UniProtKB: Q80Y47 (UniProtKB/Swiss-Prot),   Q61645 (UniProtKB/Swiss-Prot),   Q4QY90 (UniProtKB/TrEMBL)
Protein Domains
JmjC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61645-F1-model_v2 AlphaFold Q61645 1-1182 view protein structure

Promoters
RGD ID:8682926
Promoter ID:EPDNEW_M19494
Type:single initiation site
Name:Hr_2
Description:Mus musculus hairless , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M19495  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381470,554,148 - 70,554,208EPDNEW
RGD ID:8682928
Promoter ID:EPDNEW_M19495
Type:multiple initiation site
Name:Hr_1
Description:Mus musculus hairless , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M19494  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381470,554,554 - 70,554,614EPDNEW
RGD ID:6847108
Promoter ID:MM_ACW:16520
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:HR.DSEP07,   HR.ESEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361470,952,071 - 70,952,571 (+)MPROMDB
RGD ID:6825065
Promoter ID:MM_KWN:17389
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:NM_021877
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361470,953,971 - 70,954,471 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96223 AgrOrtholog
Ensembl Genes ENSMUSG00000022096 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000022691 ENTREZGENE
  ENSMUST00000022691.14 UniProtKB/Swiss-Prot
  ENSMUST00000161069 ENTREZGENE
  ENSMUST00000161069.8 UniProtKB/Swiss-Prot
  ENSMUST00000163060.2 UniProtKB/TrEMBL
Gene3D-CATH Cupin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro JHDM2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  JmjC_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15460 UniProtKB/Swiss-Prot
MGD MGI:96223 ENTREZGENE
NCBI Gene 15460 ENTREZGENE
PANTHER LYSINE-SPECIFIC DEMETHYLASE HAIRLESS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12549 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam JmjC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hr PhenoGen
PROSITE JMJC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART JmjC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Clavaminate synthase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E9PZ81_MOUSE UniProtKB/TrEMBL
  HAIR_MOUSE UniProtKB/Swiss-Prot
  Q4QY90 ENTREZGENE, UniProtKB/TrEMBL
  Q61645 ENTREZGENE
  Q80Y47 ENTREZGENE
UniProt Secondary Q80Y47 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-08-01 Hr  lysine demethylase and nuclear receptor corepressor    hairless  Symbol and/or name change 5135510 APPROVED