GNG8 (G protein subunit gamma 8) - Rat Genome Database

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Gene: GNG8 (G protein subunit gamma 8) Homo sapiens
Analyze
Symbol: GNG8
Name: G protein subunit gamma 8
RGD ID: 735730
HGNC Page HGNC:19664
Description: Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within cellular response to pheromone; nose development; and social behavior. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: g-protein gamma 8 subunit; gamma-9; guanine nucleotide binding protein (G protein), gamma 8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8; heterotrimeric guanine nucleotide-binding protein 3E; HG3E
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381946,633,953 - 46,639,326 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1946,633,953 - 46,636,541 (-)EnsemblGRCh38hg38GRCh38
GRCh371947,137,210 - 47,139,459 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361951,829,173 - 51,829,779 (-)NCBINCBI36Build 36hg18NCBI36
Build 341951,829,172 - 51,829,779NCBI
Celera1943,940,858 - 43,941,464 (-)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1943,562,343 - 43,562,949 (-)NCBIHuRef
CHM1_11947,139,178 - 47,139,784 (-)NCBICHM1_1
T2T-CHM13v2.01949,459,562 - 49,464,865 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10819326   PMID:12477932   PMID:12486123   PMID:12626323   PMID:12782285   PMID:14702039   PMID:15489334   PMID:17185339   PMID:19376773   PMID:19913121   PMID:20628086   PMID:21873635  
PMID:22940628   PMID:23773523   PMID:26002831   PMID:33961781  


Genomics

Comparative Map Data
GNG8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381946,633,953 - 46,639,326 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1946,633,953 - 46,636,541 (-)EnsemblGRCh38hg38GRCh38
GRCh371947,137,210 - 47,139,459 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361951,829,173 - 51,829,779 (-)NCBINCBI36Build 36hg18NCBI36
Build 341951,829,172 - 51,829,779NCBI
Celera1943,940,858 - 43,941,464 (-)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1943,562,343 - 43,562,949 (-)NCBIHuRef
CHM1_11947,139,178 - 47,139,784 (-)NCBICHM1_1
T2T-CHM13v2.01949,459,562 - 49,464,865 (-)NCBIT2T-CHM13v2.0
Gng8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39716,625,687 - 16,629,361 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl716,625,711 - 16,629,361 (+)EnsemblGRCm39 Ensembl
GRCm38716,891,737 - 16,895,451 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl716,891,786 - 16,895,436 (+)EnsemblGRCm38mm10GRCm38
MGSCv37717,477,135 - 17,480,784 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36716,050,308 - 16,053,957 (+)NCBIMGSCv36mm8
Celera714,098,204 - 14,101,853 (+)NCBICelera
Cytogenetic Map7A2NCBI
cM Map79.15NCBI
Gng8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8186,692,609 - 86,696,463 (+)NCBIGRCr8
mRatBN7.2177,564,512 - 77,568,371 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,564,515 - 77,568,371 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx182,946,593 - 82,948,429 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0191,510,638 - 91,512,474 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0184,701,683 - 84,703,519 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,818,360 - 78,822,224 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,818,404 - 78,822,224 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0180,065,774 - 80,069,629 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4177,221,378 - 77,223,313 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1177,299,411 - 77,301,424 (+)NCBI
Celera172,050,870 - 72,053,464 (+)NCBICelera
Cytogenetic Map1q21NCBI
Gng8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955574697,254 - 699,282 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955574697,254 - 699,282 (-)NCBIChiLan1.0ChiLan1.0
GNG8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22052,783,979 - 52,795,059 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11954,654,750 - 54,668,068 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01943,626,498 - 43,637,618 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11952,155,081 - 52,157,058 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1952,155,081 - 52,156,410 (-)Ensemblpanpan1.1panPan2
GNG8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11109,266,884 - 109,268,515 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1109,268,056 - 109,268,453 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1108,744,363 - 108,747,819 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01109,791,074 - 109,794,528 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1109,794,069 - 109,794,466 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11109,468,171 - 109,471,624 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01109,102,370 - 109,105,802 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01109,971,075 - 109,974,533 (+)NCBIUU_Cfam_GSD_1.0
Gng8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934918,877,671 - 18,881,455 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936664495,810 - 497,394 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936664495,823 - 496,296 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNG8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl652,534,662 - 52,536,414 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1652,534,952 - 52,541,115 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2647,854,442 - 47,861,734 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GNG8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1639,989,915 - 39,995,714 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl639,989,903 - 39,990,910 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607319,701,879 - 19,707,655 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gng8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248326,937,339 - 6,940,735 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248326,937,309 - 6,941,101 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GNG8
5 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19q13.32(chr19:46434490-46831000)x3 copy number gain See cases [RCV000050320] Chr19:46434490..46831000 [GRCh38]
Chr19:46937747..47334257 [GRCh37]
Chr19:51629587..52026097 [NCBI36]
Chr19:19q13.32		 uncertain significance
GRCh38/hg38 19q13.32-13.33(chr19:46458122-47683579)x1 copy number loss See cases [RCV000053976] Chr19:46458122..47683579 [GRCh38]
Chr19:46961379..48186836 [GRCh37]
Chr19:51653219..52878648 [NCBI36]
Chr19:19q13.32-13.33		 pathogenic
GRCh38/hg38 19q13.32(chr19:46434490-46831000)x3 copy number gain See cases [RCV000148268] Chr19:46434490..46831000 [GRCh38]
Chr19:46937747..47334257 [GRCh37]
Chr19:51629587..52026097 [NCBI36]
Chr19:19q13.32		 uncertain significance
GRCh37/hg19 19q13.2-13.32(chr19:43013365-47241534)x1 copy number loss See cases [RCV000240182] Chr19:43013365..47241534 [GRCh37]
Chr19:19q13.2-13.32		 pathogenic
GRCh37/hg19 19q13.32(chr19:46918881-47782258)x3 copy number gain See cases [RCV000446734] Chr19:46918881..47782258 [GRCh37]
Chr19:19q13.32		 uncertain significance
GRCh37/hg19 19q13.32-13.33(chr19:46404248-48488721)x1 copy number loss See cases [RCV000511362] Chr19:46404248..48488721 [GRCh37]
Chr19:19q13.32-13.33		 likely pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh38/hg38 19q13.32-13.33(chr19:44971420-48257402)x3 copy number gain See cases [RCV000136578] Chr19:44971420..48257402 [GRCh38]
Chr19:45474677..48760659 [GRCh37]
Chr19:50166517..53452471 [NCBI36]
Chr19:19q13.32-13.33		 pathogenic
GRCh38/hg38 19q13.32(chr19:45387389-46831000)x1 copy number loss See cases [RCV000137832] Chr19:45387389..46831000 [GRCh38]
Chr19:45890647..47334257 [GRCh37]
Chr19:50582487..52026097 [NCBI36]
Chr19:19q13.32		 likely pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic|uncertain significance
GRCh37/hg19 19q13.32-13.33(chr19:45531056-48174177)x3 copy number gain not provided [RCV001007051] Chr19:45531056..48174177 [GRCh37]
Chr19:19q13.32-13.33		 uncertain significance
NC_000019.10:g.(?_46605817)_(46756948_?)dup duplication Walker-Warburg congenital muscular dystrophy [RCV001031501] Chr19:47109074..47260205 [GRCh37]
Chr19:19q13.32		 uncertain significance
GRCh37/hg19 19q13.32-13.33(chr19:47036361-48525536) copy number gain not provided [RCV000767770] Chr19:47036361..48525536 [GRCh37]
Chr19:19q13.32-13.33		 pathogenic
GRCh37/hg19 19q13.31-13.42(chr19:44738088-53621561)x3 copy number gain not provided [RCV001007050] Chr19:44738088..53621561 [GRCh37]
Chr19:19q13.31-13.42		 pathogenic
NC_000019.9:g.(?_47104692)_(47260195_?)dup duplication Long QT syndrome 1 [RCV001918807] Chr19:47104692..47260195 [GRCh37]
Chr19:19q13.32		 uncertain significance
GRCh37/hg19 19q13.32-13.33(chr19:47028919-48185409) copy number gain Coffin-Siris syndrome 12 [RCV003232036] Chr19:47028919..48185409 [GRCh37]
Chr19:19q13.32-13.33		 likely pathogenic
NM_033258.2(GNG8):c.82A>G (p.Lys28Glu) single nucleotide variant not specified [RCV004278584] Chr19:46634601 [GRCh38]
Chr19:47137858 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_033258.2(GNG8):c.71T>C (p.Ile24Thr) single nucleotide variant not specified [RCV004623932] Chr19:46634612 [GRCh38]
Chr19:47137869 [GRCh37]
Chr19:19q13.32		 uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19q11-13.33(chr19:28271106-49213832)x3 copy number gain not provided [RCV000845733] Chr19:28271106..49213832 [GRCh37]
Chr19:19q11-13.33		 pathogenic
GRCh37/hg19 19q13.32(chr19:46918881-47782258) copy number gain not specified [RCV002052687] Chr19:46918881..47782258 [GRCh37]
Chr19:19q13.32		 uncertain significance
NM_033258.2(GNG8):c.23T>C (p.Ile8Thr) single nucleotide variant not specified [RCV004629897] Chr19:46634660 [GRCh38]
Chr19:47137917 [GRCh37]
Chr19:19q13.32		 uncertain significance
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:275
Count of miRNA genes:260
Interacting mature miRNAs:275
Transcripts:ENST00000300873
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1559110SCL22_HSerum cholesterol level QTL 22 (human)3.590.000241Lipid levelLDL cholesterol193190759457907594Human
597326491GWAS1422565_Hcolor vision disorder QTL GWAS1422565 (human)2e-08color vision disorder194663662046636621Human
597239194GWAS1335268_Habdominal fat cell number QTL GWAS1335268 (human)2e-09abdominal fat cell number194663662046636621Human
597348966GWAS1445040_Hpreeclampsia QTL GWAS1445040 (human)0.000001preeclampsia194663471546634716Human
1331657COPD9_HChronic obstructive pulmonary disease QTL 9 (human)1.94Chronic airflow obstructionpost-bronchodilator FEV1193102176057021760Human


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
880 2249 1933 2170 4385 1357 1874 3 411 1764 308 1593 6073 5808 40 3643 732 1609 1304 109 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_033258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011527524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017027503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017027504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017027505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047439725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054322686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054322687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054322688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC093503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF188179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF493875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK001010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK055324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC095514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OU666891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000300873   ⟹   ENSP00000300873
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1946,634,015 - 46,636,541 (-)Ensembl
Ensembl Acc Id: ENST00000693335   ⟹   ENSP00000508424
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1946,633,953 - 46,636,202 (-)Ensembl
RefSeq Acc Id: NM_033258   ⟹   NP_150283
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381946,633,953 - 46,636,202 (-)NCBI
GRCh371947,137,333 - 47,137,939 (-)RGD
Build 361951,829,173 - 51,829,779 (-)NCBI Archive
Celera1943,940,858 - 43,941,464 (-)RGD
HuRef1943,562,343 - 43,562,949 (-)RGD
CHM1_11947,139,178 - 47,139,784 (-)NCBI
T2T-CHM13v2.01949,459,562 - 49,461,741 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017027504   ⟹   XP_016882993
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381946,633,953 - 46,639,153 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017027505   ⟹   XP_016882994
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381946,633,953 - 46,639,326 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047439725   ⟹   XP_047295681
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381946,633,953 - 46,636,202 (-)NCBI
RefSeq Acc Id: XM_054322686   ⟹   XP_054178661
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01949,459,562 - 49,461,741 (-)NCBI
RefSeq Acc Id: XM_054322687   ⟹   XP_054178662
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01949,459,562 - 49,464,773 (-)NCBI
RefSeq Acc Id: XM_054322688   ⟹   XP_054178663
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01949,459,562 - 49,464,865 (-)NCBI
RefSeq Acc Id: NP_150283   ⟸   NM_033258
- UniProtKB: Q4VBM5 (UniProtKB/Swiss-Prot),   Q9UK08 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016882994   ⟸   XM_017027505
- Peptide Label: isoform X1
- UniProtKB: Q4VBM5 (UniProtKB/Swiss-Prot),   Q9UK08 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016882993   ⟸   XM_017027504
- Peptide Label: isoform X1
- UniProtKB: Q4VBM5 (UniProtKB/Swiss-Prot),   Q9UK08 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000300873   ⟸   ENST00000300873
Ensembl Acc Id: ENSP00000508424   ⟸   ENST00000693335
RefSeq Acc Id: XP_047295681   ⟸   XM_047439725
- Peptide Label: isoform X1
- UniProtKB: Q9UK08 (UniProtKB/Swiss-Prot),   Q4VBM5 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054178663   ⟸   XM_054322688
- Peptide Label: isoform X1
- UniProtKB: Q9UK08 (UniProtKB/Swiss-Prot),   Q4VBM5 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054178662   ⟸   XM_054322687
- Peptide Label: isoform X1
- UniProtKB: Q9UK08 (UniProtKB/Swiss-Prot),   Q4VBM5 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054178661   ⟸   XM_054322686
- Peptide Label: isoform X1
- UniProtKB: Q9UK08 (UniProtKB/Swiss-Prot),   Q4VBM5 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9UK08-F1-model_v2 AlphaFold Q9UK08 1-70 view protein structure

Promoters
RGD ID:12914175
Promoter ID:EPDNEW_H25999
Type:initiation region
Name:GNG8_1
Description:G protein subunit gamma 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26000  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381946,636,178 - 46,636,238EPDNEW
RGD ID:12914177
Promoter ID:EPDNEW_H26000
Type:multiple initiation site
Name:GNG8_2
Description:G protein subunit gamma 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H25999  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381946,636,522 - 46,636,582EPDNEW
RGD ID:6795607
Promoter ID:HG_KWN:30345
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_2Hour,   Lymphoblastoid
Transcripts:ENST00000300873
Position:
Human AssemblyChrPosition (strand)Source
Build 361951,829,091 - 51,829,591 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:19664 AgrOrtholog
COSMIC GNG8 COSMIC
Ensembl Genes ENSG00000167414 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000300873 ENTREZGENE
  ENST00000300873.5 UniProtKB/Swiss-Prot
  ENST00000693335 ENTREZGENE
  ENST00000693335.1 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.260.10 UniProtKB/Swiss-Prot
GTEx ENSG00000167414 GTEx
HGNC ID HGNC:19664 ENTREZGENE
Human Proteome Map GNG8 Human Proteome Map
InterPro G-protein_gamma-like_dom UniProtKB/Swiss-Prot
  GGL_sf UniProtKB/Swiss-Prot
  Gprotein-gamma UniProtKB/Swiss-Prot
KEGG Report hsa:94235 UniProtKB/Swiss-Prot
NCBI Gene 94235 ENTREZGENE
PANTHER PTHR13809 UniProtKB/Swiss-Prot
Pfam G-gamma UniProtKB/Swiss-Prot
PharmGKB PA134921496 PharmGKB
PRINTS GPROTEING UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_GAMMA UniProtKB/Swiss-Prot
SMART G_gamma UniProtKB/Swiss-Prot
  GGL UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48670 UniProtKB/Swiss-Prot
UniProt GBG8_HUMAN UniProtKB/Swiss-Prot
  Q4VBM5 ENTREZGENE
  Q9UK08 ENTREZGENE
UniProt Secondary Q4VBM5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-14 GNG8  G protein subunit gamma 8    guanine nucleotide binding protein (G protein), gamma 8  Symbol and/or name change 5135510 APPROVED