Gucy2d (guanylate cyclase 2d) - Rat Genome Database

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Gene: Gucy2d (guanylate cyclase 2d) Mus musculus
Analyze
Symbol: Gucy2d
Name: guanylate cyclase 2d
RGD ID: 735728
MGI Page MGI
Description: Enables odorant binding activity and olfactory receptor activity. Involved in several processes, including detection of chemical stimulus involved in sensory perception of smell; olfactory learning; and positive regulation of cGMP-mediated signaling. Predicted to be located in non-motile cilium. Predicted to be active in plasma membrane. Is expressed in spinal cord.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: guanylate cyclase D; guanylyl cyclase 2d; guanylyl cyclase D; olfactory guanylyl cyclase GC-D
RGD Orthologs
Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39798,089,623 - 98,126,685 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl798,089,623 - 98,126,686 (+)EnsemblGRCm39 Ensembl
GRCm38798,440,416 - 98,477,478 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl798,440,416 - 98,477,479 (+)EnsemblGRCm38mm10GRCm38
MGSCv377105,591,928 - 105,625,802 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367105,589,019 - 105,625,802 (+)NCBIMGSCv36mm8
Celera798,766,463 - 98,800,420 (+)NCBICelera
Cytogenetic Map7E1NCBI
cM Map753.86NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8838319   PMID:9666083   PMID:10349636   PMID:10585447   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11587854   PMID:12466851   PMID:14993224   PMID:16141072   PMID:16141073  
PMID:17702944   PMID:17724338   PMID:17942483   PMID:17954614   PMID:19181845   PMID:20637621   PMID:21078983   PMID:21873635   PMID:22623665   PMID:23564012   PMID:27238024   PMID:27703005  
PMID:27881908   PMID:30233329   PMID:32333759   PMID:32841674   PMID:38483883  


Genomics

Comparative Map Data
Gucy2d
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39798,089,623 - 98,126,685 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl798,089,623 - 98,126,686 (+)EnsemblGRCm39 Ensembl
GRCm38798,440,416 - 98,477,478 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl798,440,416 - 98,477,479 (+)EnsemblGRCm38mm10GRCm38
MGSCv377105,591,928 - 105,625,802 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367105,589,019 - 105,625,802 (+)NCBIMGSCv36mm8
Celera798,766,463 - 98,800,420 (+)NCBICelera
Cytogenetic Map7E1NCBI
cM Map753.86NCBI
Gucy2d
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81162,150,967 - 162,185,666 (+)NCBIGRCr8
mRatBN7.21152,739,775 - 152,774,474 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1152,739,775 - 152,774,473 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1160,728,333 - 160,763,686 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01167,908,500 - 167,943,846 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01160,782,029 - 160,817,377 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01163,398,891 - 163,433,594 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1163,398,891 - 163,433,593 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01169,603,078 - 169,637,802 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41155,713,465 - 155,747,852 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11155,791,870 - 155,826,041 (+)NCBI
Celera1150,829,240 - 150,863,848 (+)NCBICelera
Cytogenetic Map1q32NCBI

Variants

.
Variants in Gucy2d
2180 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:173
Count of miRNA genes:161
Interacting mature miRNAs:168
Transcripts:ENSMUST00000098274
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
27226781Tibl3_mtibia length 3, 5 week (mouse)774849748122199223Mouse
25314305Vmm6_mvariable multisystem mineralization 6, eye (mouse)761849748102749207Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
1301781Capsq3_mcapsaicin sensitivity related QTL 3 (mouse)Not determined787143137119485380Mouse
1301784Ses2_msalmonella enteritidis susceptibility 2 (mouse)Not determined767290094101290240Mouse
14746989Manh62_mmandible shape 62 (mouse)775742528109742528Mouse
27226769Tibl12_mtibia length 12, 10 week (mouse)787249208126499172Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745161966118693530Mouse
27226765Tibl18_mtibia length 18, 16 week (mouse)781849748126499172Mouse
1301383Aem2_manti-erythrocyte autoantibody modifier 2 (mouse)Not determined76413542498135653Mouse
27226763Feml20_mfemur length 20, 16 week (mouse)785049208124199223Mouse
4142500Morq1_mmodifier of Rs1 QTL 1 (mouse)Not determined80551681114551791Mouse
27095937Ulnl7_mulna length 7, 10 week (mouse)76644974898349207Mouse
1301647Elpt_melevated leptin (mouse)Not determined786500186120500329Mouse
1300620Pgia21_mproteoglycan induced arthritis 21 (mouse)Not determined767290094101290240Mouse
13208555Lgth10_mbody length 10 (mouse)751649748125599172Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)761749748121399223Mouse
1301937Skull10_mskull morphology 10 (mouse)Not determined791482996125483156Mouse
1300528Ssial3_msusceptibility to sialadenitis 3 (mouse)Not determined793391848127392041Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined739673887103510010Mouse
1301566Adip3_madiposity 3 (mouse)Not determined775394215109394346Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
1301155Bpq7_mblood pressure QTL 7 (mouse)Not determined770143137104143379Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)778649748136901729Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
27226792Feml7_mfemur length 7, 5 week (mouse)78614920898949207Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
27226790Feml15_mfemur length 15, 10 week (mouse)787249208126499172Mouse
1300654Bomd1_mbone mineral density 1 (mouse)Not determined768365595102365702Mouse
1302062Stheal6_msoft tissue heal 6 (mouse)Not determined787043932121044066Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765249748126499172Mouse
27095903Scvln10_msacral vertebrae length 2, 10 week (mouse)781449748126499172Mouse
27226715Metcl3_mmetatarsal-calcaneal length 3, 5 week (mouse)767849748119499223Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)767849748124199223Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)754819589116822815Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
10412110Cctq1_mcentral corneal thickness QTL 1 (mouse)Not determined780551681114551791Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301826Pgia3_mproteoglycan induced arthritis 3 (mouse)Not determined767290094101290240Mouse
1301188Heal6_mwound healing/regeneration 6 (mouse)Not determined787043932121044066Mouse
26884418Bzwq7_mbi-zygomatic width QTL 7, 10 week (mouse)767849748105449207Mouse
10043973Obq29_mobesity QTL 29 (mouse)Not determined772263372106263372Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
27095929Pglq8_mpelvic girdle length QTL 8, 10 week (mouse)787849208108099207Mouse
27226745Metcl9_mmetatarsal-calcaneal length 9, 10 week (mouse)774849748122199223Mouse
27095930Ulnl10_mulna length 10, 16 week (mouse)780849748126699172Mouse
27095923Pglq3_mpelvic girdle length QTL 3, 5 week (mouse)781249748124199223Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)761749748123699223Mouse
13464255Ifvrq2_minfluenza virus resistance QTL 2 (mouse)792500698106455693Mouse
1357664Nba3_mNew Zealand Black autoimmunity 3 (mouse)Not determined791482996125483156Mouse
11553865Stmm1c_mskin tumor modifier of MSM 1c (mouse)76578898699788986Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)767849748124999172Mouse
11553866Stmm1d_mskin tumor modifier of MSM 1d (mouse)76578898699788986Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773049748125699172Mouse
13463473Hbbcq4_mhemoglobin concentration QTL 4 (mouse)787043932121044066Mouse
11553869Stmm2b_mskin tumor modifier of MSM 2a (mouse)773725965107725965Mouse
27095907Scvln4_msacral vertebrae length 2, 5 week (mouse)769949748120499223Mouse
1301997Cia7_mcollagen induced arthritis QTL 7 (mouse)Not determined785365595112533819Mouse

Markers in Region
RH133869  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Celera798,778,403 - 98,778,620UniSTS
Cytogenetic Map7E2UniSTS
Cytogenetic Map7E1UniSTS
cM Map748.0UniSTS
Gucy2d  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38798,443,557 - 98,444,042UniSTSGRCm38
MGSCv377105,592,067 - 105,592,552UniSTSGRCm37
Celera798,766,602 - 98,767,087UniSTS
Cytogenetic Map7E1UniSTS
cM Map748.0UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000098274   ⟹   ENSMUSP00000095875
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl798,092,628 - 98,126,685 (+)Ensembl
GRCm38.p6 Ensembl798,443,421 - 98,477,478 (+)Ensembl
Ensembl Acc Id: ENSMUST00000205350   ⟹   ENSMUSP00000145913
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl798,116,901 - 98,124,386 (+)Ensembl
GRCm38.p6 Ensembl798,467,694 - 98,475,179 (+)Ensembl
Ensembl Acc Id: ENSMUST00000206435   ⟹   ENSMUSP00000146093
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl798,089,623 - 98,126,686 (+)Ensembl
GRCm38.p6 Ensembl798,440,416 - 98,477,479 (+)Ensembl
Ensembl Acc Id: ENSMUST00000206524
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl798,120,740 - 98,126,685 (+)Ensembl
GRCm38.p6 Ensembl798,471,533 - 98,477,478 (+)Ensembl
RefSeq Acc Id: NM_001130693   ⟹   NP_001124165
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39798,089,623 - 98,126,685 (+)NCBI
GRCm38798,440,416 - 98,477,478 (+)NCBI
MGSCv377105,591,928 - 105,625,802 (+)RGD
Celera798,763,452 - 98,800,606 (+)NCBI
cM Map7 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001124165 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A0A0U1RPR8 (Get FASTA)   NCBI Sequence Viewer  
  BAE20803 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000095875.4
  ENSMUSP00000145913.2
  ENSMUSP00000146093
  ENSMUSP00000146093.2
RefSeq Acc Id: NP_001124165   ⟸   NM_001130693
- Peptide Label: precursor
- UniProtKB: A0A0U1RPR8 (UniProtKB/TrEMBL),   F6VFS9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000146093   ⟸   ENSMUST00000206435
Ensembl Acc Id: ENSMUSP00000145913   ⟸   ENSMUST00000205350
Ensembl Acc Id: ENSMUSP00000095875   ⟸   ENSMUST00000098274
Protein Domains
Guanylate cyclase   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0U1RPR8-F1-model_v2 AlphaFold A0A0U1RPR8 1-1117 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:106030 AgrOrtholog
Ensembl Genes ENSMUSG00000074003 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000098274.5 UniProtKB/TrEMBL
  ENSMUST00000205350.2 UniProtKB/TrEMBL
  ENSMUST00000206435 ENTREZGENE
  ENSMUST00000206435.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.1230 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.780 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro A/G_cyclase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A/G_cyclase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANF_lig-bd_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclic_nucleotide_synthase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide_cyclase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14918 UniProtKB/Swiss-Prot
MGD MGI:106030 ENTREZGENE
NCBI Gene 14918 ENTREZGENE
PANTHER GUANYLATE CYCLASE D UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GUANYLYL CYCLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ANF_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanylate_cyc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gucy2d PhenoGen
PROSITE GUANYLATE_CYCLASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GUANYLATE_CYCLASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CYCc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55073 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0U1RPB5_MOUSE UniProtKB/TrEMBL
  A0A0U1RPR8 ENTREZGENE
  F6VFS9 ENTREZGENE, UniProtKB/TrEMBL
  GUC2D_MOUSE UniProtKB/Swiss-Prot
  Q3V2J4_MOUSE UniProtKB/TrEMBL