GRIK3 (glutamate ionotropic receptor kainate type subunit 3) - Rat Genome Database

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Gene: GRIK3 (glutamate ionotropic receptor kainate type subunit 3) Homo sapiens
Analyze
Symbol: GRIK3
Name: glutamate ionotropic receptor kainate type subunit 3
RGD ID: 735713
HGNC Page HGNC:4581
Description: Enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity and kainate selective glutamate receptor activity. Involved in G protein-coupled glutamate receptor signaling pathway. Acts upstream of or within regulation of membrane potential. Located in plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: dJ1090M5.1 (glutamate receptor, ionotropic, kainate 3 (GLUR7)); EAA5; excitatory amino acid receptor 5; GLR7; GluK3; gluR-7; GLUR7; GluR7a; glutamate receptor 7; glutamate receptor ionotropic, kainate 3; glutamate receptor, ionotropic kainate 3; glutamate receptor, ionotropic, kainate 3
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38136,795,527 - 37,034,515 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl136,795,527 - 37,034,515 (-)EnsemblGRCh38hg38GRCh38
GRCh37137,261,128 - 37,500,116 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36137,039,201 - 37,272,431 (-)NCBINCBI36Build 36hg18NCBI36
Build 34136,935,706 - 37,168,937NCBI
Celera135,537,937 - 35,776,956 (-)NCBICelera
Cytogenetic Map1p34.3NCBI
HuRef135,378,101 - 35,617,482 (-)NCBIHuRef
CHM1_1137,377,032 - 37,615,785 (-)NCBICHM1_1
T2T-CHM13v2.0136,659,019 - 36,898,269 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (ISO)
Aflatoxin B2 alpha  (EXP)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
bisphenol AF  (ISO)
bleomycin A2  (ISO)
calcitriol  (EXP)
celecoxib  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
clobetasol  (ISO)
cocaine  (ISO)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (EXP)
diazinon  (ISO)
dieldrin  (ISO)
disodium selenite  (EXP)
dorsomorphin  (EXP)
ethanol  (ISO)
ethylparaben  (EXP)
fenamidone  (ISO)
folic acid  (ISO)
fonofos  (EXP)
glycidol  (ISO)
ivermectin  (EXP)
kainic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
manganese(II) chloride  (EXP,ISO)
methotrexate  (EXP)
methoxychlor  (ISO)
methylmercury chloride  (EXP)
methylphenidate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
panobinostat  (EXP)
paraquat  (ISO)
parathion  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (EXP)
SB 431542  (EXP)
Se-methyl-L-selenocysteine  (EXP)
Se-methylselenocysteine  (EXP)
terbufos  (EXP)
testosterone  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triptonide  (ISO)
valproic acid  (EXP,ISO)
vorinostat  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7719709   PMID:8128318   PMID:8163463   PMID:9144652   PMID:9466455   PMID:10737800   PMID:11124978   PMID:11943148   PMID:11986986   PMID:15094479   PMID:15897672   PMID:16314883  
PMID:16325263   PMID:16356644   PMID:16958029   PMID:17213182   PMID:18423838   PMID:19022628   PMID:19086053   PMID:19125103   PMID:19221446   PMID:19320626   PMID:19342380   PMID:19921975  
PMID:19995671   PMID:20052609   PMID:20379614   PMID:20859245   PMID:20951142   PMID:21873635   PMID:22232963   PMID:23006490   PMID:23894747   PMID:24449200   PMID:26354767   PMID:28005267  
PMID:28631555   PMID:29058671   PMID:30021884   PMID:30977227   PMID:34127015  


Genomics

Comparative Map Data
GRIK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38136,795,527 - 37,034,515 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl136,795,527 - 37,034,515 (-)EnsemblGRCh38hg38GRCh38
GRCh37137,261,128 - 37,500,116 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36137,039,201 - 37,272,431 (-)NCBINCBI36Build 36hg18NCBI36
Build 34136,935,706 - 37,168,937NCBI
Celera135,537,937 - 35,776,956 (-)NCBICelera
Cytogenetic Map1p34.3NCBI
HuRef135,378,101 - 35,617,482 (-)NCBIHuRef
CHM1_1137,377,032 - 37,615,785 (-)NCBICHM1_1
T2T-CHM13v2.0136,659,019 - 36,898,269 (-)NCBIT2T-CHM13v2.0
Grik3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394125,384,025 - 125,607,966 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4125,384,493 - 125,607,966 (+)EnsemblGRCm39 Ensembl
GRCm384125,490,259 - 125,714,173 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4125,490,700 - 125,714,173 (+)EnsemblGRCm38mm10GRCm38
MGSCv374125,168,075 - 125,391,417 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364124,993,135 - 125,210,652 (+)NCBIMGSCv36mm8
Celera4123,816,415 - 124,039,344 (+)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map458.91NCBI
Grik3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85143,052,442 - 143,268,873 (+)NCBIGRCr8
mRatBN7.25137,767,865 - 137,989,617 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5137,767,865 - 137,984,307 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5140,472,191 - 140,689,693 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05142,242,199 - 142,459,708 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05142,249,392 - 142,466,887 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05143,500,441 - 143,715,546 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5143,500,441 - 143,715,546 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05147,265,647 - 147,485,816 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45144,842,374 - 145,058,047 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15144,852,366 - 145,068,040 (+)NCBI
Celera5136,284,413 - 136,500,298 (+)NCBICelera
Cytogenetic Map5q36NCBI
Grik3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545214,725,097 - 14,933,658 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545214,719,072 - 14,933,613 (-)NCBIChiLan1.0ChiLan1.0
GRIK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21189,812,527 - 190,051,624 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11188,940,771 - 189,180,310 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0136,060,594 - 36,312,781 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1137,413,660 - 37,651,769 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl137,415,254 - 37,651,705 (-)Ensemblpanpan1.1panPan2
GRIK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1155,331,746 - 5,550,975 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl155,331,717 - 5,549,181 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha155,577,336 - 5,796,363 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0155,469,481 - 5,690,516 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl155,468,814 - 5,690,461 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1155,323,496 - 5,544,551 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0155,389,938 - 5,612,163 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0155,405,832 - 5,626,868 (+)NCBIUU_Cfam_GSD_1.0
Grik3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505853,325,517 - 53,538,754 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647419,156,172 - 19,363,542 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647419,151,896 - 19,363,497 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRIK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl692,880,303 - 93,128,569 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1692,880,297 - 93,128,048 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2685,950,875 - 86,193,744 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRIK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12095,832,480 - 96,069,890 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2095,832,864 - 96,063,577 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603320,731,558 - 20,968,669 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grik3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476419,655,782 - 19,860,119 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476419,649,780 - 19,860,077 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GRIK3
75 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_000831.3(GRIK3):c.115+27720C>T single nucleotide variant Lung cancer [RCV000090819] Chr1:37006274 [GRCh38]
Chr1:37471875 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.3(GRIK3):c.115+20141C>T single nucleotide variant Lung cancer [RCV000090820] Chr1:37013853 [GRCh38]
Chr1:37479454 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.694G>A (p.Asp232Asn) single nucleotide variant not provided [RCV001090924] Chr1:36872226 [GRCh38]
Chr1:37337827 [GRCh37]
Chr1:37110414 [NCBI36]
Chr1:1p34.3
uncertain significance|not provided
NM_000831.3(GRIK3):c.123C>T (p.Ile41=) single nucleotide variant Malignant melanoma [RCV000060188] Chr1:36891089 [GRCh38]
Chr1:37356690 [GRCh37]
Chr1:37129277 [NCBI36]
Chr1:1p34.3
not provided
GRCh38/hg38 1p34.3(chr1:35934217-36821999)x4 copy number gain See cases [RCV000138892] Chr1:35934217..36821999 [GRCh38]
Chr1:36399818..37287600 [GRCh37]
Chr1:36172405..37060187 [NCBI36]
Chr1:1p34.3
likely pathogenic
GRCh38/hg38 1p36.11-34.2(chr1:24381206-41401517)x3 copy number gain See cases [RCV000138891] Chr1:24381206..41401517 [GRCh38]
Chr1:24707696..41886350 [GRCh37]
Chr1:24580283..41658937 [NCBI36]
Chr1:1p36.11-34.2
pathogenic
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 copy number loss not provided [RCV000762767] Chr1:20608823..120546301 [GRCh37]
Chr1:1p36.12-12
likely benign
NM_000831.4(GRIK3):c.1268G>A (p.Arg423Gln) single nucleotide variant not provided [RCV004691116]|not specified [RCV000239080] Chr1:36850369 [GRCh38]
Chr1:37315970 [GRCh37]
Chr1:1p34.3
uncertain significance
GRCh37/hg19 1p34.3(chr1:37469062-37699272)x1 copy number loss See cases [RCV000446231] Chr1:37469062..37699272 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.2456A>G (p.Gln819Arg) single nucleotide variant not specified [RCV000501485] Chr1:36805096 [GRCh38]
Chr1:37270697 [GRCh37]
Chr1:1p34.3
uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
NM_000831.4(GRIK3):c.2407A>G (p.Ser803Gly) single nucleotide variant not specified [RCV004321270] Chr1:36805145 [GRCh38]
Chr1:37270746 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.817C>A (p.Arg273Ser) single nucleotide variant not specified [RCV004323883] Chr1:36859987 [GRCh38]
Chr1:37325588 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.331G>A (p.Gly111Ser) single nucleotide variant not specified [RCV004332706] Chr1:36880853 [GRCh38]
Chr1:37346454 [GRCh37]
Chr1:1p34.3
uncertain significance
NC_000001.10:g.(?_33241563)_(46663513_?)dup duplication Charcot-Marie-Tooth disease dominant intermediate C [RCV000708276] Chr1:33241563..46663513 [GRCh37]
Chr1:1p35.1-34.1
uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p35.2-34.3(chr1:31562164-37421958)x3 copy number gain not provided [RCV000748949] Chr1:31562164..37421958 [GRCh37]
Chr1:1p35.2-34.3
pathogenic
GRCh37/hg19 1p34.3(chr1:37421958-37425742)x1 copy number loss not provided [RCV000748958] Chr1:37421958..37425742 [GRCh37]
Chr1:1p34.3
benign
GRCh37/hg19 1p34.3(chr1:37423534-37425364)x1 copy number loss not provided [RCV000748959] Chr1:37423534..37425364 [GRCh37]
Chr1:1p34.3
benign
GRCh37/hg19 1p34.3(chr1:37423534-37425742)x1 copy number loss not provided [RCV000748960] Chr1:37423534..37425742 [GRCh37]
Chr1:1p34.3
benign
GRCh37/hg19 1p34.3(chr1:37423534-37430266)x1 copy number loss not provided [RCV000748961] Chr1:37423534..37430266 [GRCh37]
Chr1:1p34.3
benign
GRCh37/hg19 1p34.3(chr1:37425133-37425511)x1 copy number loss not provided [RCV000748962] Chr1:37425133..37425511 [GRCh37]
Chr1:1p34.3
benign
NM_000831.4(GRIK3):c.828C>T (p.Gly276=) single nucleotide variant not provided [RCV000905948] Chr1:36859976 [GRCh38]
Chr1:37325577 [GRCh37]
Chr1:1p34.3
benign
NM_000831.4(GRIK3):c.2314+8A>T single nucleotide variant not provided [RCV000902370] Chr1:36806096 [GRCh38]
Chr1:37271697 [GRCh37]
Chr1:1p34.3
likely benign
NM_000831.4(GRIK3):c.453C>T (p.Asn151=) single nucleotide variant not provided [RCV000969134] Chr1:36880731 [GRCh38]
Chr1:37346332 [GRCh37]
Chr1:1p34.3
benign
NM_000831.4(GRIK3):c.1105-4G>A single nucleotide variant not provided [RCV000883646] Chr1:36853726 [GRCh38]
Chr1:37319327 [GRCh37]
Chr1:1p34.3
benign
NM_000831.4(GRIK3):c.129G>A (p.Glu43=) single nucleotide variant not provided [RCV000895697] Chr1:36891083 [GRCh38]
Chr1:37356684 [GRCh37]
Chr1:1p34.3
likely benign
NM_000831.4(GRIK3):c.189T>C (p.Ser63=) single nucleotide variant not provided [RCV000918299] Chr1:36891023 [GRCh38]
Chr1:37356624 [GRCh37]
Chr1:1p34.3
likely benign
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3 copy number gain Global developmental delay [RCV000787285] Chr1:103343285..103455144 [GRCh37]
Chr1:1p36.22-21.1
uncertain significance
NM_000831.4(GRIK3):c.807G>A (p.Leu269=) single nucleotide variant not provided [RCV000958450] Chr1:36859997 [GRCh38]
Chr1:37325598 [GRCh37]
Chr1:1p34.3
benign
NM_000831.4(GRIK3):c.562C>T (p.Leu188=) single nucleotide variant not provided [RCV000955147] Chr1:36872358 [GRCh38]
Chr1:37337959 [GRCh37]
Chr1:1p34.3
benign
NM_000831.4(GRIK3):c.879G>A (p.Ser293=) single nucleotide variant not provided [RCV000907810] Chr1:36859925 [GRCh38]
Chr1:37325526 [GRCh37]
Chr1:1p34.3
benign
NM_000831.4(GRIK3):c.468C>T (p.Tyr156=) single nucleotide variant not provided [RCV000912816] Chr1:36880716 [GRCh38]
Chr1:37346317 [GRCh37]
Chr1:1p34.3
benign
NM_000831.4(GRIK3):c.84C>A (p.Asp28Glu) single nucleotide variant not provided [RCV000912421] Chr1:37034025 [GRCh38]
Chr1:37499626 [GRCh37]
Chr1:1p34.3
benign
NM_000831.4(GRIK3):c.1410A>G (p.Leu470=) single nucleotide variant not provided [RCV000890747] Chr1:36841856 [GRCh38]
Chr1:37307457 [GRCh37]
Chr1:1p34.3
benign
NC_000001.10:g.(?_33241563)_(46663513_?)dup duplication Charcot-Marie-Tooth disease, dominant intermediate C [RCV001308684] Chr1:33241563..46663513 [GRCh37]
Chr1:1p35.1-34.1
uncertain significance
GRCh37/hg19 1p34.3(chr1:36041366-39112237) copy number loss not specified [RCV002053236] Chr1:36041366..39112237 [GRCh37]
Chr1:1p34.3
uncertain significance
GRCh37/hg19 1p34.3(chr1:37469062-37699272) copy number loss not specified [RCV002053247] Chr1:37469062..37699272 [GRCh37]
Chr1:1p34.3
uncertain significance
GRCh37/hg19 1p35.1-33(chr1:33285582-47891811) copy number gain not specified [RCV002052781] Chr1:33285582..47891811 [GRCh37]
Chr1:1p35.1-33
pathogenic
GRCh37/hg19 1p34.3(chr1:35104233-37357913)x1 copy number loss not provided [RCV002474552] Chr1:35104233..37357913 [GRCh37]
Chr1:1p34.3
pathogenic
NM_000831.4(GRIK3):c.1985C>T (p.Thr662Ile) single nucleotide variant not specified [RCV004086136] Chr1:36817166 [GRCh38]
Chr1:37282767 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.874G>A (p.Val292Ile) single nucleotide variant not specified [RCV004142380] Chr1:36859930 [GRCh38]
Chr1:37325531 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.857A>G (p.Asn286Ser) single nucleotide variant not specified [RCV004220690] Chr1:36859947 [GRCh38]
Chr1:37325548 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.2191A>G (p.Thr731Ala) single nucleotide variant not specified [RCV004130051] Chr1:36806227 [GRCh38]
Chr1:37271828 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.810G>C (p.Glu270Asp) single nucleotide variant not specified [RCV004218702] Chr1:36859994 [GRCh38]
Chr1:37325595 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.1987G>A (p.Val663Met) single nucleotide variant not specified [RCV004071097] Chr1:36817164 [GRCh38]
Chr1:37282765 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.361G>A (p.Val121Ile) single nucleotide variant not specified [RCV004210557] Chr1:36880823 [GRCh38]
Chr1:37346424 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.625A>G (p.Ile209Val) single nucleotide variant not specified [RCV004085696] Chr1:36872295 [GRCh38]
Chr1:37337896 [GRCh37]
Chr1:1p34.3
likely benign
NM_000831.4(GRIK3):c.2600G>A (p.Arg867His) single nucleotide variant not specified [RCV004233048] Chr1:36802011 [GRCh38]
Chr1:37267612 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.1509G>T (p.Met503Ile) single nucleotide variant not specified [RCV004264769] Chr1:36841757 [GRCh38]
Chr1:37307358 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.166G>A (p.Glu56Lys) single nucleotide variant not specified [RCV004259448] Chr1:36891046 [GRCh38]
Chr1:37356647 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.619C>T (p.Leu207Phe) single nucleotide variant not specified [RCV004271509] Chr1:36872301 [GRCh38]
Chr1:37337902 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.1031C>A (p.Thr344Asn) single nucleotide variant not specified [RCV004332784] Chr1:36859181 [GRCh38]
Chr1:37324782 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.2567G>A (p.Arg856His) single nucleotide variant not specified [RCV004258883] Chr1:36802044 [GRCh38]
Chr1:37267645 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.134C>A (p.Ala45Glu) single nucleotide variant not specified [RCV004325792] Chr1:36891078 [GRCh38]
Chr1:37356679 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.1525G>A (p.Asp509Asn) single nucleotide variant not specified [RCV004355186] Chr1:36841741 [GRCh38]
Chr1:37307342 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.2402G>A (p.Arg801Gln) single nucleotide variant not specified [RCV004355069] Chr1:36805150 [GRCh38]
Chr1:37270751 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.52G>A (p.Gly18Arg) single nucleotide variant not specified [RCV004351834] Chr1:37034057 [GRCh38]
Chr1:37499658 [GRCh37]
Chr1:1p34.3
uncertain significance
Single allele inversion Bilateral polymicrogyria [RCV003459046] Chr1:33246132..61045156 [GRCh38]
Chr1:1p35.1-31.3
likely pathogenic
NM_000831.4(GRIK3):c.1545C>T (p.Ala515=) single nucleotide variant not provided [RCV003406353] Chr1:36825812 [GRCh38]
Chr1:37291413 [GRCh37]
Chr1:1p34.3
likely benign
NM_000831.4(GRIK3):c.2565+28A>G single nucleotide variant not provided [RCV003406351] Chr1:36804959 [GRCh38]
Chr1:37270560 [GRCh37]
Chr1:1p34.3
likely benign
NM_000831.4(GRIK3):c.2166C>T (p.Asn722=) single nucleotide variant not provided [RCV003406352] Chr1:36806252 [GRCh38]
Chr1:37271853 [GRCh37]
Chr1:1p34.3
likely benign
NM_000831.4(GRIK3):c.2329G>A (p.Asp777Asn) single nucleotide variant not specified [RCV004393827] Chr1:36805223 [GRCh38]
Chr1:37270824 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.1234G>A (p.Asp412Asn) single nucleotide variant not specified [RCV004393823] Chr1:36850403 [GRCh38]
Chr1:37316004 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.2578A>C (p.Ser860Arg) single nucleotide variant not specified [RCV004393829] Chr1:36802033 [GRCh38]
Chr1:37267634 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.683G>A (p.Arg228His) single nucleotide variant not specified [RCV004393837] Chr1:36872237 [GRCh38]
Chr1:37337838 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.1387G>A (p.Glu463Lys) single nucleotide variant not specified [RCV004393824] Chr1:36841879 [GRCh38]
Chr1:37307480 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.1913T>C (p.Ile638Thr) single nucleotide variant not specified [RCV004393826] Chr1:36817238 [GRCh38]
Chr1:37282839 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.2590G>A (p.Asp864Asn) single nucleotide variant not specified [RCV004393830] Chr1:36802021 [GRCh38]
Chr1:37267622 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.407G>A (p.Arg136His) single nucleotide variant not specified [RCV004393833] Chr1:36880777 [GRCh38]
Chr1:37346378 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.614G>A (p.Arg205His) single nucleotide variant not specified [RCV004393835] Chr1:36872306 [GRCh38]
Chr1:37337907 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.17G>A (p.Arg6Gln) single nucleotide variant not specified [RCV004393825] Chr1:37034092 [GRCh38]
Chr1:37499693 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.2389G>A (p.Glu797Lys) single nucleotide variant not specified [RCV004393828] Chr1:36805163 [GRCh38]
Chr1:37270764 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.2671G>A (p.Val891Ile) single nucleotide variant not specified [RCV004393832] Chr1:36801940 [GRCh38]
Chr1:37267541 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.926G>A (p.Arg309Gln) single nucleotide variant not specified [RCV004393838] Chr1:36859878 [GRCh38]
Chr1:37325479 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.25C>G (p.Arg9Gly) single nucleotide variant not specified [RCV004393831] Chr1:37034084 [GRCh38]
Chr1:37499685 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.463G>A (p.Asp155Asn) single nucleotide variant not specified [RCV004393834] Chr1:36880721 [GRCh38]
Chr1:37346322 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.72C>G (p.Phe24Leu) single nucleotide variant not specified [RCV004634792] Chr1:37034037 [GRCh38]
Chr1:37499638 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.2546A>G (p.Lys849Arg) single nucleotide variant not specified [RCV004634793] Chr1:36805006 [GRCh38]
Chr1:37270607 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.2324A>T (p.Tyr775Phe) single nucleotide variant not specified [RCV004624038] Chr1:36805228 [GRCh38]
Chr1:37270829 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.829G>A (p.Val277Met) single nucleotide variant not specified [RCV004634790] Chr1:36859975 [GRCh38]
Chr1:37325576 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.1804G>A (p.Glu602Lys) single nucleotide variant not specified [RCV004634791] Chr1:36819805 [GRCh38]
Chr1:37285406 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.487A>G (p.Ile163Val) single nucleotide variant not specified [RCV004634794] Chr1:36880697 [GRCh38]
Chr1:37346298 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_000831.4(GRIK3):c.1382G>A (p.Arg461Gln) single nucleotide variant not specified [RCV004344307] Chr1:36841884 [GRCh38]
Chr1:37307485 [GRCh37]
Chr1:1p34.3
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4860
Count of miRNA genes:1361
Interacting mature miRNAs:1813
Transcripts:ENST00000373091, ENST00000373093, ENST00000462621, ENST00000479620
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
597093910GWAS1189984_HFEV/FVC ratio, response to bronchodilator QTL GWAS1189984 (human)0.000002FEV/FVC ratio, response to bronchodilatorforced expiratory volume to forced vital capacity ratio (CMO:0000241)13684019336840194Human
596964855GWAS1084374_Hdiet measurement, HbA1c measurement QTL GWAS1084374 (human)0.000004diet measurement, HbA1c measurementblood hemoglobin A1c level (CMO:0002786)13695521036955211Human
597334301GWAS1430375_HAlzheimer disease, APOE carrier status QTL GWAS1430375 (human)0.000005Alzheimer disease, APOE carrier status13697277936972780Human
596964862GWAS1084381_Hdiet measurement, HbA1c measurement QTL GWAS1084381 (human)0.000009diet measurement, HbA1c measurementblood hemoglobin A1c level (CMO:0002786)13695521036955211Human
597155068GWAS1251142_Hdiet measurement, HbA1c measurement QTL GWAS1251142 (human)0.000009diet measurement, HbA1c measurementblood hemoglobin A1c level (CMO:0002786)13695521036955211Human
597143770GWAS1239844_HAPOE carrier status, dementia QTL GWAS1239844 (human)0.000007APOE carrier status, dementia13696520936965210Human
597162630GWAS1258704_Hcysteine measurement QTL GWAS1258704 (human)0.000001cysteine measurement13683618736836188Human
597154502GWAS1250576_Hdiet measurement, HbA1c measurement QTL GWAS1250576 (human)0.000004diet measurement, HbA1c measurementblood hemoglobin A1c level (CMO:0002786)13695521036955211Human
407051696GWAS700672_Haspartate measurement QTL GWAS700672 (human)0.000001blood L-aspartic acid amount (VT:0010969)13691070136910702Human
597092771GWAS1188845_HFEV/FVC ratio, response to bronchodilator QTL GWAS1188845 (human)0.000003FEV/FVC ratio, response to bronchodilatorforced expiratory volume to forced vital capacity ratio (CMO:0000241)13684710436847105Human
597058467GWAS1154541_Hadolescent idiopathic scoliosis QTL GWAS1154541 (human)0.000001adolescent idiopathic scoliosis13688520436885205Human
597162978GWAS1259052_Hnucleotide measurement QTL GWAS1259052 (human)0.00001nucleotide metabolism trait (VT:0003806)13693658336936584Human
597093153GWAS1189227_HFEV/FVC ratio, response to bronchodilator QTL GWAS1189227 (human)0.000003FEV/FVC ratio, response to bronchodilatorforced expiratory volume to forced vital capacity ratio (CMO:0000241)13684378936843790Human
597217408GWAS1313482_Hbone density QTL GWAS1313482 (human)3e-08bone mineral mass (VT:0005007)bone mineral density (CMO:0001226)13680373136803732Human
407369720GWAS1018696_Hacute myeloid leukemia QTL GWAS1018696 (human)0.000002leukocyte integrity trait (VT:0010898)13696657936966580Human
597277254GWAS1373328_Hdiet measurement QTL GWAS1373328 (human)4e-09diet measurementfood intake measurement (CMO:0000772)13702109137021092Human

Markers in Region
D1S472  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37137,433,803 - 37,433,922UniSTSGRCh37
GRCh37137,433,743 - 37,433,980UniSTSGRCh37
Build 36137,206,390 - 37,206,509RGDNCBI36
Celera135,710,917 - 35,711,034RGD
Celera135,710,857 - 35,711,092UniSTS
Cytogenetic Map1p34.3UniSTS
HuRef135,551,918 - 35,552,035UniSTS
HuRef135,551,858 - 35,552,093UniSTS
Marshfield Genetic Map165.47UniSTS
Marshfield Genetic Map165.47RGD
Genethon Genetic Map166.6UniSTS
TNG Radiation Hybrid Map117941.0UniSTS
deCODE Assembly Map157.95UniSTS
Stanford-G3 RH Map11811.0UniSTS
GeneMap99-GB4 RH Map1113.98UniSTS
NCBI RH Map1251.9UniSTS
GeneMap99-G3 RH Map12081.0UniSTS
G15720  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37137,474,606 - 37,474,767UniSTSGRCh37
Build 36137,247,193 - 37,247,354RGDNCBI36
Celera135,751,723 - 35,751,884RGD
Cytogenetic Map1p34.3UniSTS
HuRef135,592,244 - 35,592,405UniSTS
Marshfield Genetic Map165.47UniSTS
Marshfield Genetic Map165.47RGD
deCODE Assembly Map158.07UniSTS
SHGC-74612  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37137,262,094 - 37,262,315UniSTSGRCh37
Build 36137,034,681 - 37,034,902RGDNCBI36
Celera135,538,903 - 35,539,124RGD
Cytogenetic Map1p34.3UniSTS
HuRef135,379,067 - 35,379,288UniSTS
TNG Radiation Hybrid Map117845.0UniSTS
GeneMap99-GB4 RH Map1112.58UniSTS
AL034266  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37137,395,299 - 37,395,457UniSTSGRCh37
Build 36137,167,886 - 37,168,044RGDNCBI36
Celera135,672,095 - 35,672,253RGD
Cytogenetic Map1p34.3UniSTS
HuRef135,512,261 - 35,512,419UniSTS
RH103118  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37137,261,255 - 37,261,418UniSTSGRCh37
Build 36137,033,842 - 37,034,005RGDNCBI36
Celera135,538,064 - 35,538,227RGD
Cytogenetic Map1p34.3UniSTS
HuRef135,378,228 - 35,378,391UniSTS
GeneMap99-GB4 RH Map1112.28UniSTS
G59361  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37137,471,590 - 37,471,925UniSTSGRCh37
Build 36137,244,177 - 37,244,512RGDNCBI36
Celera135,748,707 - 35,749,042RGD
Cytogenetic Map1p34.3UniSTS
HuRef135,589,228 - 35,589,563UniSTS
TNG Radiation Hybrid Map117954.0UniSTS
D1S1444  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37137,299,963 - 37,300,128UniSTSGRCh37
Build 36137,072,550 - 37,072,715RGDNCBI36
Celera135,576,763 - 35,576,928RGD
Cytogenetic Map1p34.3UniSTS
HuRef135,416,927 - 35,417,092UniSTS
D11S4066  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37137,261,173 - 37,261,300UniSTSGRCh37
Build 36137,033,760 - 37,033,887RGDNCBI36
Celera135,537,982 - 35,538,109RGD
Cytogenetic Map1p34.3UniSTS
HuRef135,378,146 - 35,378,273UniSTS
SHGC-143130  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37137,402,127 - 37,402,458UniSTSGRCh37
Build 36137,174,714 - 37,175,045RGDNCBI36
Celera135,678,923 - 35,679,255RGD
Cytogenetic Map1p34.3UniSTS
HuRef135,519,089 - 35,519,421UniSTS
TNG Radiation Hybrid Map117919.0UniSTS
SHGC-112050  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37137,407,818 - 37,408,107UniSTSGRCh37
Build 36137,180,405 - 37,180,694RGDNCBI36
Celera135,684,615 - 35,684,904RGD
Cytogenetic Map1p34.3UniSTS
HuRef135,524,781 - 35,525,070UniSTS
TNG Radiation Hybrid Map117894.0UniSTS
GRIK3_966  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37137,266,522 - 37,267,255UniSTSGRCh37
Build 36137,039,109 - 37,039,842RGDNCBI36
Celera135,543,331 - 35,544,064RGD
HuRef135,383,495 - 35,384,228UniSTS
RH79120  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37137,266,628 - 37,266,769UniSTSGRCh37
Build 36137,039,215 - 37,039,356RGDNCBI36
Celera135,543,437 - 35,543,578RGD
Cytogenetic Map1p34.3UniSTS
HuRef135,383,601 - 35,383,742UniSTS
GeneMap99-GB4 RH Map1111.15UniSTS
NCBI RH Map1251.9UniSTS
AL010015  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37137,395,253 - 37,395,441UniSTSGRCh37
Build 36137,167,840 - 37,168,028RGDNCBI36
Celera135,672,049 - 35,672,237RGD
Cytogenetic Map1p34.3UniSTS
HuRef135,512,215 - 35,512,403UniSTS
AL009961  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37137,422,489 - 37,422,612UniSTSGRCh37
Build 36137,195,076 - 37,195,199RGDNCBI36
Celera135,699,284 - 35,699,407RGD
Cytogenetic Map1p34.3UniSTS
HuRef135,539,450 - 35,540,472UniSTS
HuRef135,539,450 - 35,539,573UniSTS
SHGC-31550  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37137,267,207 - 37,267,411UniSTSGRCh37
Build 36137,039,794 - 37,039,998RGDNCBI36
Celera135,544,016 - 35,544,220RGD
Cytogenetic Map1p34.3UniSTS
HuRef135,384,180 - 35,384,384UniSTS
TNG Radiation Hybrid Map117849.0UniSTS
Stanford-G3 RH Map11776.0UniSTS
NCBI RH Map1251.9UniSTS
GeneMap99-G3 RH Map12046.0UniSTS
D1S472  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1p34.3UniSTS
TNG Radiation Hybrid Map117941.0UniSTS
Stanford-G3 RH Map11811.0UniSTS
GeneMap99-GB4 RH Map1113.98UniSTS
NCBI RH Map1251.9UniSTS
GeneMap99-G3 RH Map12081.0UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1200 2300 2778 2211 4834 1505 1933 420 1311 258 2209 6224 5775 24 3656 737 1617 1408 162

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_011447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC117945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ249210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ299451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ308525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ308526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL355386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL591883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW898512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG057125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG818719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI544689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ446793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DR003075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DT217951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S69349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U16127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U16128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000373091   ⟹   ENSP00000362183
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl136,795,527 - 37,034,515 (-)Ensembl
Ensembl Acc Id: ENST00000373093   ⟹   ENSP00000362185
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl136,804,618 - 37,034,129 (-)Ensembl
Ensembl Acc Id: ENST00000462621
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl136,849,674 - 36,859,136 (-)Ensembl
Ensembl Acc Id: ENST00000479620
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl136,849,948 - 36,853,687 (-)Ensembl
RefSeq Acc Id: NM_000831   ⟹   NP_000822
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38136,795,527 - 37,034,515 (-)NCBI
GRCh37137,261,128 - 37,499,844 (-)ENTREZGENE
Build 36137,039,201 - 37,272,431 (-)NCBI Archive
HuRef135,378,101 - 35,617,482 (-)ENTREZGENE
CHM1_1137,377,032 - 37,615,785 (-)NCBI
T2T-CHM13v2.0136,659,019 - 36,898,269 (-)NCBI
Sequence:
RefSeq Acc Id: NP_000822   ⟸   NM_000831
- Peptide Label: precursor
- UniProtKB: Q13003 (UniProtKB/Swiss-Prot),   Q13004 (UniProtKB/Swiss-Prot),   B1AMS6 (UniProtKB/Swiss-Prot),   A9Z1Z8 (UniProtKB/Swiss-Prot),   Q16136 (UniProtKB/Swiss-Prot),   Q96QG5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000362183   ⟸   ENST00000373091
Ensembl Acc Id: ENSP00000362185   ⟸   ENST00000373093
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q13003-F1-model_v2 AlphaFold Q13003 1-919 view protein structure

Promoters
RGD ID:6855000
Promoter ID:EPDNEW_H664
Type:initiation region
Name:GRIK3_1
Description:glutamate ionotropic receptor kainate type subunit 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38137,034,613 - 37,034,673EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4581 AgrOrtholog
COSMIC GRIK3 COSMIC
Ensembl Genes ENSG00000163873 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000373091 ENTREZGENE
  ENST00000373091.8 UniProtKB/Swiss-Prot
  ENST00000373093.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Periplasmic binding protein-like II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000163873 GTEx
HGNC ID HGNC:4581 ENTREZGENE
Human Proteome Map GRIK3 Human Proteome Map
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glu/Gly-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iono_rcpt_met UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ionotropic_Glu_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iontro_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2899 UniProtKB/Swiss-Prot
NCBI Gene 2899 ENTREZGENE
OMIM 138243 OMIM
PANTHER IONOTROPIC GLUTAMATE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ANF_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lig_chan UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lig_chan-Glu_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA28975 PharmGKB
PRINTS NMDARECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Lig_chan-Glu_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PBPe UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Periplasmic binding protein-like II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A9Z1Z8 ENTREZGENE
  B1AMS6 ENTREZGENE
  GRIK3_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q13004 ENTREZGENE
  Q16136 ENTREZGENE
  Q96QG5 ENTREZGENE, UniProtKB/TrEMBL
  Q96SC0_HUMAN UniProtKB/TrEMBL
  Q96SC1_HUMAN UniProtKB/TrEMBL
  Q96SC2_HUMAN UniProtKB/TrEMBL
UniProt Secondary A9Z1Z8 UniProtKB/Swiss-Prot
  B1AMS6 UniProtKB/Swiss-Prot
  Q13004 UniProtKB/Swiss-Prot
  Q16136 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-10 GRIK3  glutamate ionotropic receptor kainate type subunit 3  GRIK3  glutamate receptor, ionotropic, kainate 3  Symbol and/or name change 5135510 APPROVED