Ncoa6 (nuclear receptor coactivator 6) - Rat Genome Database

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Gene: Ncoa6 (nuclear receptor coactivator 6) Mus musculus
Analyze
Symbol: Ncoa6
Name: nuclear receptor coactivator 6
RGD ID: 735678
MGI Page MGI
Description: Enables several functions, including chromatin-protein adaptor activity; histone methyltransferase binding activity; and transcription coactivator activity. Acts upstream of or within brain development; circulatory system development; and positive regulation of DNA-templated transcription. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in breast cancer; colon cancer; and lung cancer. Orthologous to human NCOA6 (nuclear receptor coactivator 6).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: activating signal cointegrator 2; AI; AIB3; amplified in breast cancer protein 3; AS; ASC; ASC-2; ASC2; cancer-amplified transcriptional coactivator ASC-2; MGC90663; mKIAA0181; N; Ncoa7; NRC; nuclear receptor coactivator RAP250; nuclear receptor-activating protein 250; nuclear receptor-activating protein, 250 kDa; peroxisome proliferator-activated receptor interacting protein,PRIP; peroxisome proliferator-activated receptor-interacting protein; PPAR interacting protein PRIP; PPAR-interacting protein; PRIP; RAP; RAP250; thyroid hormone receptor binding protein; thyroid hormone receptor-binding protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392155,232,585 - 155,315,741 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2155,232,576 - 155,315,814 (-)EnsemblGRCm39 Ensembl
GRCm382155,390,656 - 155,473,911 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2155,390,656 - 155,473,894 (-)EnsemblGRCm38mm10GRCm38
MGSCv372155,216,401 - 155,266,519 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362155,082,112 - 155,129,567 (-)NCBIMGSCv36mm8
Celera2161,323,189 - 161,373,222 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map277.26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal atrial thrombosis  (IAGP)
abnormal bile salt homeostasis  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal brain development  (IAGP)
abnormal branching of the mammary ductal tree  (IAGP)
abnormal cell physiology  (IAGP)
abnormal circulating triglyceride level  (IAGP)
abnormal decidualization  (IAGP)
abnormal digit morphology  (IAGP)
abnormal embryonic hematopoiesis  (IAGP)
abnormal epicardium morphology  (IAGP)
abnormal eye pigmentation  (IAGP)
abnormal feces composition  (IAGP)
abnormal fetal cardiomyocyte morphology  (IAGP)
abnormal fetal cardiomyocyte proliferation  (IAGP)
abnormal heart development  (IAGP)
abnormal heart echocardiography feature  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal hypothalamus morphology  (IAGP)
abnormal lens morphology  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal lipid level  (IAGP)
abnormal liver bud morphology  (IAGP)
abnormal liver development  (IAGP)
abnormal liver morphology  (IAGP)
abnormal luminal closure  (IAGP)
abnormal mammary duct terminal end bud morphology  (IAGP)
abnormal mammary gland development  (IAGP)
abnormal mammary gland growth during lactation  (IAGP)
abnormal mammary gland growth during pregnancy  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal palatal shelf fusion at midline  (IAGP)
abnormal placenta development  (IAGP)
abnormal placenta morphology  (IAGP)
abnormal placenta vasculature  (IAGP)
abnormal placental labyrinth vasculature morphology  (IAGP)
abnormal retina morphology  (IEA)
abnormal sarcomere morphology  (IAGP)
abnormal spongiotrophoblast layer morphology  (IAGP)
abnormal syncytiotrophoblast morphology  (IAGP)
abnormal trophoblast giant cell morphology  (IAGP)
abnormal trophoblast layer morphology  (IAGP)
abnormal uterine receptivity  (IAGP)
abnormal vascular development  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
absent olfactory bulb  (IAGP)
absent placental labyrinth  (IAGP)
cardiac hypertrophy  (IAGP)
cataract  (IAGP)
decreased birth body size  (IAGP)
decreased birth weight  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased embryo size  (IAGP)
decreased erythroid progenitor cell number  (IAGP)
decreased fetal cardiomyocyte proliferation  (IAGP)
decreased fibroblast proliferation  (IAGP)
decreased hair follicle number  (IAGP)
decreased hepatocyte number  (IAGP)
decreased litter size  (IAGP)
decreased mitochondrial number  (IAGP)
decreased neuron number  (IAGP)
decreased spongiotrophoblast cell number  (IAGP)
decreased spongiotrophoblast size  (IAGP)
decreased total body fat amount  (IEA)
delayed brain development  (IAGP)
delayed wound healing  (IAGP)
detached epicardium  (IAGP)
dilated cardiomyopathy  (IAGP)
dilated heart  (IAGP)
dilated heart left ventricle  (IAGP)
dilated third ventricle  (IAGP)
dilated vasculature  (IAGP)
disorganized myocardium  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
female infertility  (IAGP)
heart hypoplasia  (IAGP)
hindlimb oligodactyly  (IAGP)
hypolactation  (IAGP)
impaired placental function  (IAGP)
impaired wound healing  (IAGP)
increased circulating cholesterol level  (IAGP)
increased fibroblast apoptosis  (IAGP)
increased heart weight  (IAGP)
increased hepatocyte apoptosis  (IAGP)
increased liver weight  (IAGP)
increased sebaceous gland number  (IAGP)
increased trophoblast giant cell number  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
pallor  (IAGP)
pericardial effusion  (IAGP)
premature death  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, incomplete penetrance  (IEA)
reduced female fertility  (IAGP)
reduced male fertility  (IAGP)
small lens  (IAGP)
small liver  (IAGP)
small thalamus  (IAGP)
thick epidermis  (IAGP)
thin myocardium  (IAGP)
thin myocardium compact layer  (IAGP)
thin ventricular wall  (IAGP)
trabecula carnea hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Trbp regulates heart function through microRNA-mediated Sox6 repression. Ding J, etal., Nat Genet. 2015 Jul;47(7):776-83. doi: 10.1038/ng.3324. Epub 2015 Jun 1.
2. Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting. Hall JM and McDonnell DP, Mol Interv. 2005 Dec;5(6):343-57.
3. A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo. Lee SK, etal., J Biol Chem. 1999 Nov 26;274(48):34283-93.
4. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis. Shilatifard A Annu Rev Biochem. 2012;81:65-95. doi: 10.1146/annurev-biochem-051710-134100.
10. MicroRNA-208a Dysregulates Apoptosis Genes Expression and Promotes Cardiomyocyte Apoptosis during Ischemia and Its Silencing Improves Cardiac Function after Myocardial Infarction. Tony H, etal., Mediators Inflamm. 2015;2015:479123. doi: 10.1155/2015/479123. Epub 2015 Nov 25.
11. Regulation of insulin secretion and beta-cell mass by activating signal cointegrator 2. Yeom SY, etal., Mol Cell Biol. 2006 Jun;26(12):4553-63.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10681503   PMID:10788465   PMID:10866662   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11704680   PMID:12368298   PMID:12446700  
PMID:12446761   PMID:12446833   PMID:12466851   PMID:12477932   PMID:12556486   PMID:12639927   PMID:12754253   PMID:14610273   PMID:14621295   PMID:14681479   PMID:14980720   PMID:15143190  
PMID:15150259   PMID:15161927   PMID:15466215   PMID:15489334   PMID:15769905   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16738322   PMID:16828057   PMID:17021013   PMID:17500065  
PMID:17605299   PMID:17908797   PMID:17962186   PMID:18263591   PMID:18372346   PMID:18799693   PMID:19228596   PMID:19329434   PMID:19342446   PMID:19433796   PMID:19556342   PMID:20484573  
PMID:21267068   PMID:21330447   PMID:21552418   PMID:21757756   PMID:21873635   PMID:22496869   PMID:22794259   PMID:22861055   PMID:22982455   PMID:23079602   PMID:24952961   PMID:25131203  
PMID:25981537   PMID:26180087   PMID:26706316   PMID:28291835   PMID:28341745   PMID:28435063   PMID:30186101   PMID:34321999   PMID:34474245   PMID:35258009   PMID:38195836  


Genomics

Comparative Map Data
Ncoa6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392155,232,585 - 155,315,741 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2155,232,576 - 155,315,814 (-)EnsemblGRCm39 Ensembl
GRCm382155,390,656 - 155,473,911 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2155,390,656 - 155,473,894 (-)EnsemblGRCm38mm10GRCm38
MGSCv372155,216,401 - 155,266,519 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362155,082,112 - 155,129,567 (-)NCBIMGSCv36mm8
Celera2161,323,189 - 161,373,222 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map277.26NCBI
NCOA6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382034,714,774 - 34,825,651 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2034,689,097 - 34,825,651 (-)EnsemblGRCh38hg38GRCh38
GRCh372033,302,578 - 33,413,454 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362032,766,239 - 32,877,094 (-)NCBINCBI36Build 36hg18NCBI36
Build 342032,766,238 - 32,877,094NCBI
Celera2030,051,663 - 30,162,529 (-)NCBICelera
Cytogenetic Map20q11.22NCBI
HuRef2030,081,569 - 30,192,220 (-)NCBIHuRef
CHM1_12033,204,060 - 33,314,823 (-)NCBICHM1_1
T2T-CHM13v2.02036,435,437 - 36,546,294 (-)NCBIT2T-CHM13v2.0
Ncoa6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83164,351,062 - 164,422,079 (-)NCBIGRCr8
mRatBN7.23143,890,896 - 143,961,916 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3143,890,896 - 143,952,268 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3147,757,713 - 147,797,978 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03156,374,984 - 156,415,249 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03154,114,516 - 154,154,781 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03150,919,317 - 150,990,391 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3150,919,317 - 150,960,030 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03157,287,434 - 157,358,499 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43145,886,874 - 145,957,928 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13145,808,879 - 145,815,141 (-)NCBI
Celera3142,616,753 - 142,657,466 (-)NCBICelera
Cytogenetic Map3q41-q42NCBI
Ncoa6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542226,564,037 - 26,632,675 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542226,564,535 - 26,639,516 (+)NCBIChiLan1.0ChiLan1.0
NCOA6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22140,448,796 - 40,559,276 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12040,441,963 - 40,552,376 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02031,044,339 - 31,154,798 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12032,170,583 - 32,247,167 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2032,170,583 - 32,247,167 (-)Ensemblpanpan1.1panPan2
NCOA6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12423,802,360 - 23,877,986 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2423,802,351 - 23,866,792 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2423,447,946 - 23,539,033 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02424,493,126 - 24,584,695 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2424,493,113 - 24,581,564 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12423,780,970 - 23,872,054 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02423,876,107 - 23,967,330 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02424,314,983 - 24,406,060 (-)NCBIUU_Cfam_GSD_1.0
Ncoa6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640172,766,751 - 172,862,411 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365615,906,485 - 5,982,268 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365615,905,905 - 5,982,824 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NCOA6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1738,114,291 - 38,221,901 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11738,114,284 - 38,221,904 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21743,309,959 - 43,393,797 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NCOA6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1239,013,364 - 39,129,723 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl239,013,232 - 39,129,658 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605087,702,887 - 87,819,956 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ncoa6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248424,570,758 - 4,665,517 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:833
Count of miRNA genes:457
Interacting mature miRNAs:515
Transcripts:ENSMUST00000043126, ENSMUST00000109669, ENSMUST00000109670, ENSMUST00000123293, ENSMUST00000134508, ENSMUST00000141928, ENSMUST00000143909, ENSMUST00000146942
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301907Rends_mrenal disease susceptibility (mouse)Not determined2135699221169699361Mouse
1301783Bhr1_mbronchial hyperresponsiveness 1 (mouse)Not determined2142593476178442452Mouse
12790983Bwq12_mbody weight QTL 12 (mouse)2148238204181755017Mouse
1301019Bmd6_mbone mineral density 6 (mouse)Not determined2151778297181755017Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118589253160611165Mouse
1558939Gnf1_mgrowth and fatness 1 (mouse)Not determined2143773445169117924Mouse
13825247Agoc2_magouti coat color QTL 2 (mouse)2151841920159841920Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118589253160611165Mouse
1300867Lore2_mloss of righting induced by ethanol 2 (mouse)Not determined2144515861180896594Mouse
1558917Gct8_mgranulosa cell tumorigenesis 8 (mouse)Not determined2149236907181755017Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118589253160611165Mouse
14747002Mancz3_mmandible centroid size 3 (mouse)2152329820181755017Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118589253160611165Mouse
1300751Bdt1_mbone density traits 1 (mouse)Not determined2149988902181755017Mouse
10054066Bwq9_mbody weight QTL 9 (mouse)Not determined2135699221169699361Mouse
1301822Pgia2_mproteoglycan induced arthritis 2 (mouse)Not determined2123937311157937424Mouse
1558842Tailq2_mtail length QTL 2 (mouse)Not determined2151640941162737074Mouse
10043956Gnf5_mgrowth and fatness 5 (mouse)Not determined2135699221169699361Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
10412080Hylaq2_mHyperlocomotor activity related QTL 2 (mouse)Not determined2151640941164119146Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
1357862Epfq1_mepididymal fat pad weight QTL 1 (mouse)Not determined2151640941162737074Mouse
1301031Bdln3_mbody length 3 (mouse)Not determined2127664019161664118Mouse
1357484Bsbob_mBSB obesity (mouse)Not determined2143773445165665019Mouse
4141703Chlq13_mcirculating hormone level QTL 13 (mouse)Not determined2135699221169699361Mouse
11341717Rvfs1_mRift Valley fever susceptibility 1 (mouse)2135432544173449616Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102630345159941920Mouse
4142211Nilac3_mnicotine induced locomotor activity 3 (mouse)Not determined2148664893181755017Mouse
1301294Hrtfm5_mheart failure modifier 5 (mouse)Not determined2122883015156883131Mouse
1558867Gnf3_mgrowth and fatness 3 (mouse)Not determined2152699221169117924Mouse
11038701Ltpr2e_mLeishmania tropica response 2e (mouse)2150212221181755017Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
1301588Hrec_mhemotopoietic response to early cytokines (mouse)Not determined2154553217159428450Mouse
4142450Lmr16_mleishmaniasis resistance 16 (mouse)Not determined2150212221181755017Mouse
1301085Lrnx10_mlearning-contextual 10 (mouse)Not determined2150212221181755017Mouse
11353826Bdln10_mbody length 10 (mouse)2140441482174441482Mouse
1558852Gnf2_mgrowth and fatness 2 (mouse)Not determined2152699221162197085Mouse
1300806Aod4_mautoimmune ovarian dysgenesis 4 (mouse)Not determined2145228719179228841Mouse
4141033Wg2d_mweight gain in high growth mice 2d (mouse)Not determined143773445160303008Mouse
1357772Scfq1_msubcutaneous fat pad weight QTL 1 (mouse)Not determined2151640941162737074Mouse
1301961Bts1_mbladder tumor susceptibility 1 (mouse)Not determined2132024159166024330Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2117942930174324863Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124441920168241920Mouse
13524521Bodwtq2_mbody wweight QTL 2 (mouse)2153456184156386184Mouse
1302143Bwq5_mbody weight (mouse)Not determined2127664019161664118Mouse
1302013Tbbmd3_mtotal body bone mineral density 3 (mouse)Not determined2145196949179197085Mouse
12880427V25Dq3_mvitamin D inactive form serum level QTL 3 (mouse)2129341920163341920Mouse
13504830Bacsq1_mbaculum shape QTL 1 (mouse)2145716184161016184Mouse
12801456Intmrm1_mintima/media ratio modifier 1 (mouse)2142428347176428450Mouse
12801461Intim1_mintima modifier 1 (mouse)2142428347176428450Mouse
11049566Lmr28e_mleishmaniasis resistance 28e (mouse)2133144911167145058Mouse
11049567Lmr28f_mleishmaniasis resistance 28f (mouse)2133144911167145058Mouse
1301865Hdlq19_mHDL QTL 19 (mouse)Not determined2145518775179518926Mouse
12910520Scgq3_mspontaneous crescentic glomerulonephritis QTL 3 (mouse)2151709273174389124Mouse
1300846Pbwg11_mpostnatal body weight growth 11 (mouse)Not determined2138966600172966729Mouse

Markers in Region
PMC141133P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382155,412,404 - 155,413,209UniSTSGRCm38
MGSCv372155,238,140 - 155,238,945UniSTSGRCm37
Celera2161,344,859 - 161,345,664UniSTS
Cytogenetic Map2H2UniSTS
Ncoa6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2H2UniSTS
cM Map277.26UniSTS
D20S712E  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382155,390,828 - 155,390,916UniSTSGRCm38
MGSCv372155,216,564 - 155,216,652UniSTSGRCm37
Celera2161,323,352 - 161,323,440UniSTS
Cytogenetic Map2H2UniSTS
Ncoa6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2H2UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001242558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001406325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001406326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF135169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF216186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF525078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK136585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK142566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL844852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL845325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC083187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ056778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JF707634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JF707635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JF707636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000043126   ⟹   ENSMUSP00000045386
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2155,232,576 - 155,282,703 (-)Ensembl
GRCm38.p6 Ensembl2155,390,656 - 155,440,783 (-)Ensembl
Ensembl Acc Id: ENSMUST00000109669   ⟹   ENSMUSP00000105294
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2155,262,197 - 155,282,705 (-)Ensembl
GRCm38.p6 Ensembl2155,420,277 - 155,440,785 (-)Ensembl
Ensembl Acc Id: ENSMUST00000109670   ⟹   ENSMUSP00000105295
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2155,232,585 - 155,315,726 (-)Ensembl
GRCm38.p6 Ensembl2155,390,665 - 155,473,806 (-)Ensembl
Ensembl Acc Id: ENSMUST00000123293   ⟹   ENSMUSP00000118113
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2155,248,753 - 155,315,814 (-)Ensembl
GRCm38.p6 Ensembl2155,406,833 - 155,473,894 (-)Ensembl
Ensembl Acc Id: ENSMUST00000134508
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2155,279,930 - 155,315,744 (-)Ensembl
GRCm38.p6 Ensembl2155,438,010 - 155,473,824 (-)Ensembl
Ensembl Acc Id: ENSMUST00000141928
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2155,257,307 - 155,260,823 (-)Ensembl
GRCm38.p6 Ensembl2155,415,387 - 155,418,903 (-)Ensembl
Ensembl Acc Id: ENSMUST00000143909
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2155,232,589 - 155,238,746 (-)Ensembl
GRCm38.p6 Ensembl2155,390,669 - 155,396,826 (-)Ensembl
Ensembl Acc Id: ENSMUST00000146942
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2155,232,589 - 155,245,481 (-)Ensembl
GRCm38.p6 Ensembl2155,390,669 - 155,403,561 (-)Ensembl
RefSeq Acc Id: NM_001242558   ⟹   NP_001229487
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392155,232,585 - 155,315,741 (-)NCBI
GRCm382155,390,656 - 155,440,783 (-)NCBI
Celera2161,323,180 - 161,373,222 (-)ENTREZGENE
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001406325   ⟹   NP_001393254
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392155,232,585 - 155,315,741 (-)NCBI
RefSeq Acc Id: NM_001406326   ⟹   NP_001393255
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392155,232,585 - 155,315,741 (-)NCBI
RefSeq Acc Id: NM_019825   ⟹   NP_062799
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392155,232,585 - 155,315,741 (-)NCBI
GRCm382155,390,656 - 155,440,783 (-)NCBI
MGSCv372155,216,401 - 155,266,519 (-)RGD
Celera2161,323,180 - 161,373,222 (-)ENTREZGENE
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_062799   ⟸   NM_019825
- Peptide Label: isoform 1
- UniProtKB: Q9JLT9 (UniProtKB/Swiss-Prot),   Q9JL19 (UniProtKB/Swiss-Prot),   Q5XJV5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001229487   ⟸   NM_001242558
- Peptide Label: isoform 2
- UniProtKB: F6M2J9 (UniProtKB/TrEMBL),   F6M2K1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000105294   ⟸   ENSMUST00000109669
Ensembl Acc Id: ENSMUSP00000105295   ⟸   ENSMUST00000109670
Ensembl Acc Id: ENSMUSP00000118113   ⟸   ENSMUST00000123293
Ensembl Acc Id: ENSMUSP00000045386   ⟸   ENSMUST00000043126
RefSeq Acc Id: NP_001393255   ⟸   NM_001406326
- Peptide Label: isoform 1
- UniProtKB: Q5XJV5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001393254   ⟸   NM_001406325
- Peptide Label: isoform 1
- UniProtKB: Q5XJV5 (UniProtKB/TrEMBL)
Protein Domains
Nuclear receptor coactivator 6 TRADD-N

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JL19-F1-model_v2 AlphaFold Q9JL19 1-2067 view protein structure

Promoters
RGD ID:6847670
Promoter ID:MM_ACW:30233
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:NCOA6.FSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362155,241,066 - 155,241,566 (-)MPROMDB
RGD ID:6879350
Promoter ID:EPDNEW_M3126
Type:multiple initiation site
Name:Ncoa6_1
Description:Mus musculus nuclear receptor coactivator 6 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382155,473,806 - 155,473,866EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1929915 AgrOrtholog
Ensembl Genes ENSMUSG00000038369 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000043126 ENTREZGENE
  ENSMUST00000043126.12 UniProtKB/TrEMBL
  ENSMUST00000109669.8 UniProtKB/TrEMBL
  ENSMUST00000109670 ENTREZGENE
  ENSMUST00000109670.8 UniProtKB/TrEMBL
  ENSMUST00000123293.8 UniProtKB/TrEMBL
InterPro NCOA6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NCOA6_nucleic_acid-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:56406 UniProtKB/TrEMBL
MGD MGI:1929915 ENTREZGENE
NCBI Gene 56406 ENTREZGENE
PANTHER NUCLEAR RECEPTOR COACTIVATOR 6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15690 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Nucleic_acid_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ncoa6 PhenoGen
UniProt A2AQM9_MOUSE UniProtKB/TrEMBL
  A2AQN0_MOUSE UniProtKB/TrEMBL
  F6M2J9 ENTREZGENE, UniProtKB/TrEMBL
  F6M2K0_MOUSE UniProtKB/TrEMBL
  F6M2K1 ENTREZGENE, UniProtKB/TrEMBL
  NCOA6_MOUSE UniProtKB/Swiss-Prot
  Q3TAG3_MOUSE UniProtKB/TrEMBL
  Q3UQD5_MOUSE UniProtKB/TrEMBL
  Q5XJV5 ENTREZGENE, UniProtKB/TrEMBL
  Q6ZQH3_MOUSE UniProtKB/TrEMBL
  Q9JL19 ENTREZGENE
  Q9JLT9 ENTREZGENE
UniProt Secondary Q9JLT9 UniProtKB/Swiss-Prot